locus-tag	class	description
SMAL454_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMAL454_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMAL454_RS00020	COG0187	DNA topoisomerase II activity
SMAL454_RS00030	COG0501	Belongs to the peptidase M48B family
SMAL454_RS00125	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS00205	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMAL454_RS00215	COG4772	TonB-dependent receptor
SMAL454_RS00250	COG0800	Aldolase
SMAL454_RS00265	COG3186	Phenylalanine-4-hydroxylase
SMAL454_RS00270	COG1522	sequence-specific DNA binding
SMAL454_RS00280	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMAL454_RS00290	COG4771	TonB-dependent receptor
SMAL454_RS00310	COG1119	ATPase activity
SMAL454_RS00325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMAL454_RS00330	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SMAL454_RS00350	COG0210	DNA helicase
SMAL454_RS00360	COG3132	Protein of unknown function, DUF480
SMAL454_RS00365	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SMAL454_RS00370	COG0284	orotidine-5'-phosphate decarboxylase activity
SMAL454_RS00380	COG2937	Belongs to the GPAT DAPAT family
SMAL454_RS00390	COG0037	tRNA processing
SMAL454_RS00395	COG2974	May be involved in recombination
SMAL454_RS00405	COG1803	Methylglyoxal synthase
SMAL454_RS00410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMAL454_RS00410	COG2205	protein histidine kinase activity
SMAL454_RS00415	COG0493	'glutamate synthase
SMAL454_RS00420	COG0067	glutamate synthase
SMAL454_RS00420	COG0069	glutamate synthase activity
SMAL454_RS00420	COG0070	glutamate synthase
SMAL454_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS00460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMAL454_RS00485	COG1111	helicase
SMAL454_RS00485	COG1205	dead DEAH box helicase
SMAL454_RS00520	COG0714	Associated with various cellular activities
SMAL454_RS00540	COG0312	modulator of DNA gyrase
SMAL454_RS00560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMAL454_RS00580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMAL454_RS00605	COG1881	PFAM PEBP family protein
SMAL454_RS00620	COG1968	undecaprenyl-diphosphatase activity
SMAL454_RS00625	COG0174	glutamine synthetase
SMAL454_RS00630	COG0347	Belongs to the P(II) protein family
SMAL454_RS00635	COG0004	ammonium transporteR
SMAL454_RS00695	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SMAL454_RS00710	COG3852	Histidine kinase
SMAL454_RS00715	COG2204	response regulator
SMAL454_RS00720	COG2032	superoxide dismutase activity
SMAL454_RS00725	COG2032	superoxide dismutase activity
SMAL454_RS00735	COG0183	Belongs to the thiolase family
SMAL454_RS00770	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SMAL454_RS00775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMAL454_RS00795	COG0798	PFAM Bile acid sodium symporter
SMAL454_RS00815	COG0431	NADPH-dependent FMN reductase
SMAL454_RS00850	COG2837	iron assimilation
SMAL454_RS00890	COG2197	response regulator
SMAL454_RS00895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMAL454_RS00895	COG2205	protein histidine kinase activity
SMAL454_RS00900	COG3474	cytochrome
SMAL454_RS00910	COG1960	acyl-CoA dehydrogenase activity
SMAL454_RS00915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SMAL454_RS00925	COG0612	Peptidase, M16
SMAL454_RS00935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMAL454_RS00940	COG0596	Alpha beta hydrolase
SMAL454_RS00950	COG0318	PFAM AMP-dependent synthetase and ligase
SMAL454_RS00955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMAL454_RS00965	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMAL454_RS00975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMAL454_RS00990	COG1215	transferase activity, transferring glycosyl groups
SMAL454_RS00995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMAL454_RS01025	COG0339	signal peptide processing
SMAL454_RS01030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMAL454_RS01040	COG0681	Belongs to the peptidase S26 family
SMAL454_RS01045	COG2814	Major facilitator Superfamily
SMAL454_RS01050	COG0583	DNA-binding transcription factor activity
SMAL454_RS01055	COG0583	DNA-binding transcription factor activity
SMAL454_RS01060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMAL454_RS01065	COG2224	Isocitrate lyase
SMAL454_RS01070	COG3706	GGDEF domain
SMAL454_RS01095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMAL454_RS01100	COG1960	acyl-CoA dehydrogenase activity
SMAL454_RS01120	COG0697	spore germination
SMAL454_RS01130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SMAL454_RS01140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMAL454_RS01150	COG1280	lysine exporter protein (LysE YggA)
SMAL454_RS01155	COG1607	acyl-coa hydrolase
SMAL454_RS01165	COG1902	pentaerythritol trinitrate reductase activity
SMAL454_RS01180	COG1335	isochorismatase
SMAL454_RS01185	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMAL454_RS01195	COG1056	cytidyltransferase-related domain
SMAL454_RS01195	COG1051	belongs to the nudix hydrolase family
SMAL454_RS01200	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMAL454_RS01215	COG3800	Transcriptional regulator
SMAL454_RS01215	COG1396	sequence-specific DNA binding
SMAL454_RS01225	COG1960	acyl-CoA dehydrogenase activity
SMAL454_RS01230	COG1024	Enoyl-CoA hydratase
SMAL454_RS01235	COG1024	Enoyl-CoA hydratase
SMAL454_RS01245	COG1764	response to oxidative stress
SMAL454_RS01420	COG3179	chitinase
SMAL454_RS01465	COG4695	Portal protein
SMAL454_RS01495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMAL454_RS01515	COG3228	Belongs to the MtfA family
SMAL454_RS01525	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SMAL454_RS01525	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SMAL454_RS01530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SMAL454_RS01545	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMAL454_RS01580	COG3237	CsbD-like
SMAL454_RS01590	COG0180	Tryptophanyl-tRNA synthetase
SMAL454_RS01615	COG0477	Major facilitator Superfamily
SMAL454_RS01625	COG4152	abc transporter atp-binding protein
SMAL454_RS01640	COG0697	spore germination
SMAL454_RS01655	COG1136	(ABC) transporter
SMAL454_RS01655	COG0577	efflux transmembrane transporter activity
SMAL454_RS01665	COG1136	(ABC) transporter
SMAL454_RS01685	COG4585	Histidine kinase
SMAL454_RS01700	COG0753	catalase activity
SMAL454_RS01705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMAL454_RS01715	COG0628	permease
SMAL454_RS01735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMAL454_RS01750	COG5507	3-demethylubiquinone-9 3-methyltransferase
SMAL454_RS01780	COG2814	Major facilitator Superfamily
SMAL454_RS01785	COG0583	DNA-binding transcription factor activity
SMAL454_RS01790	COG4807	Protein conserved in bacteria
SMAL454_RS01800	COG4221	oxidoreductase activity
SMAL454_RS01810	COG0018	arginyl-trna synthetase
SMAL454_RS01820	COG2197	response regulator
SMAL454_RS01825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMAL454_RS01830	COG0756	dUTP diphosphatase activity
SMAL454_RS01845	COG2205	protein histidine kinase activity
SMAL454_RS01855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMAL454_RS01860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMAL454_RS01875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMAL454_RS01880	COG0708	Exodeoxyribonuclease III
SMAL454_RS01885	COG2223	nitrite transmembrane transporter activity
SMAL454_RS01900	COG0739	heme binding
SMAL454_RS01905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMAL454_RS01990	COG2234	aminopeptidase activity
SMAL454_RS02000	COG4942	peptidase
SMAL454_RS02005	COG0793	Belongs to the peptidase S41A family
SMAL454_RS02015	COG2067	long-chain fatty acid transport protein
SMAL454_RS02045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMAL454_RS02090	COG0109	protoheme IX farnesyltransferase activity
SMAL454_RS02110	COG0358	DNA primase activity
SMAL454_RS02115	COG1295	ribonuclease BN
SMAL454_RS02130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMAL454_RS02140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMAL454_RS02145	COG0668	transmembrane transport
SMAL454_RS02160	COG2133	pyrroloquinoline quinone binding
SMAL454_RS02165	COG4682	membrane
SMAL454_RS02175	COG0531	amino acid
SMAL454_RS02185	COG1737	Transcriptional regulator
SMAL454_RS02190	COG4948	Mandelate Racemase Muconate Lactonizing
SMAL454_RS02210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMAL454_RS02240	COG5383	Protein conserved in bacteria
SMAL454_RS02250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SMAL454_RS02255	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SMAL454_RS02285	COG0778	Nitroreductase
SMAL454_RS02290	COG2353	YceI-like domain
SMAL454_RS02305	COG2375	cellular response to nickel ion
SMAL454_RS02345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMAL454_RS02350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMAL454_RS02420	COG2267	carboxylic ester hydrolase activity
SMAL454_RS02490	COG0488	(ABC) transporter
SMAL454_RS02495	COG0583	DNA-binding transcription factor activity
SMAL454_RS02505	COG2814	Major facilitator Superfamily
SMAL454_RS02510	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SMAL454_RS02515	COG1113	amino acid transport
SMAL454_RS02520	COG0741	lytic transglycosylase activity
SMAL454_RS02535	COG3795	YCII-related domain
SMAL454_RS02545	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SMAL454_RS02555	COG5507	3-demethylubiquinone-9 3-methyltransferase
SMAL454_RS02560	COG4941	Belongs to the sigma-70 factor family
SMAL454_RS02590	COG3275	phosphorelay sensor kinase activity
SMAL454_RS02595	COG3279	Response regulator of the LytR AlgR family
SMAL454_RS02615	COG1309	transcriptional regulator
SMAL454_RS02630	COG3590	peptidase
SMAL454_RS02635	COG5001	Diguanylate cyclase
SMAL454_RS02640	COG0583	DNA-binding transcription factor activity
SMAL454_RS02650	COG3384	dioxygenase
SMAL454_RS02655	COG0025	NhaP-type Na H and K H
SMAL454_RS02680	COG1360	Flagellar Motor Protein
SMAL454_RS02710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMAL454_RS02725	COG5002	protein histidine kinase activity
SMAL454_RS02740	COG2813	Specifically methylates the guanine in position
SMAL454_RS02745	COG1187	pseudouridine synthase activity
SMAL454_RS02750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMAL454_RS02760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMAL454_RS02765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMAL454_RS02780	COG0583	DNA-binding transcription factor activity
SMAL454_RS02785	COG2226	methyltransferase
SMAL454_RS02810	COG1956	GAF domain-containing protein
SMAL454_RS02815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMAL454_RS02820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMAL454_RS02825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMAL454_RS02830	COG0785	Cytochrome C biogenesis protein
SMAL454_RS02830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMAL454_RS02835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMAL454_RS02840	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS02845	COG2205	protein histidine kinase activity
SMAL454_RS02850	COG2205	protein histidine kinase activity
SMAL454_RS02855	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS02860	COG0367	asparagine synthase
SMAL454_RS02870	COG0720	synthase
SMAL454_RS02885	COG0513	Belongs to the DEAD box helicase family
SMAL454_RS02895	COG0625	glutathione transferase activity
SMAL454_RS02900	COG1573	uracil-dna glycosylase
SMAL454_RS02935	COG0626	cystathionine gamma-synthase activity
SMAL454_RS02950	COG0110	maltose O-acetyltransferase activity
SMAL454_RS02955	COG1216	Glycosyl transferase, family 2
SMAL454_RS02955	COG0438	transferase activity, transferring glycosyl groups
SMAL454_RS02960	COG3754	Rhamnan synthesis protein F
SMAL454_RS03000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMAL454_RS03005	COG2226	methyltransferase
SMAL454_RS03010	COG0300	oxidoreductase activity
SMAL454_RS03020	COG0546	phosphoglycolate phosphatase activity
SMAL454_RS03020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMAL454_RS03035	COG2076	Multidrug Resistance protein
SMAL454_RS03110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMAL454_RS03115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMAL454_RS03150	COG1127	ABC transporter
SMAL454_RS03155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMAL454_RS03170	COG0442	prolyl-tRNA aminoacylation
SMAL454_RS03180	COG1183	phosphatidylcholine synthase activity
SMAL454_RS03190	COG0456	acetyltransferase
SMAL454_RS03200	COG0525	valine-tRNA ligase activity
SMAL454_RS03210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMAL454_RS03220	COG0795	lipopolysaccharide-transporting ATPase activity
SMAL454_RS03235	COG4974	Belongs to the 'phage' integrase family
SMAL454_RS03240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMAL454_RS03250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMAL454_RS03250	COG0047	phosphoribosylformylglycinamidine synthase activity
SMAL454_RS03255	COG5295	Hep Hag repeat protein
SMAL454_RS03260	COG1404	Belongs to the peptidase S8 family
SMAL454_RS03265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMAL454_RS03270	COG1459	type II secretion system
SMAL454_RS03275	COG2165	general secretion pathway protein
SMAL454_RS03280	COG4970	Tfp pilus assembly protein FimT
SMAL454_RS03285	COG2165	general secretion pathway protein
SMAL454_RS03290	COG4795	General secretion pathway protein
SMAL454_RS03295	COG3156	type II secretion system protein K
SMAL454_RS03300	COG3166	PFAM Fimbrial assembly family protein
SMAL454_RS03315	COG1450	Type ii and iii secretion system protein
SMAL454_RS03325	COG0463	Glycosyl transferase, family 2
SMAL454_RS03340	COG3539	Fimbrial protein
SMAL454_RS03360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMAL454_RS03370	COG1215	transferase activity, transferring glycosyl groups
SMAL454_RS03385	COG2252	PERMEase
SMAL454_RS03390	COG0488	(ABC) transporter
SMAL454_RS03400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMAL454_RS03420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMAL454_RS03425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMAL454_RS03425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMAL454_RS03455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMAL454_RS03460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMAL454_RS03470	COG3121	Chaperone
SMAL454_RS03485	COG3188	usher protein
SMAL454_RS03495	COG2755	lipolytic protein G-D-S-L family
SMAL454_RS03495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMAL454_RS03500	COG0277	FAD linked oxidase domain protein
SMAL454_RS03505	COG1988	membrane-bound metal-dependent
SMAL454_RS03540	COG2001	Belongs to the MraZ family
SMAL454_RS03545	COG0275	rRNA processing
SMAL454_RS03550	COG3116	cell division
SMAL454_RS03560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMAL454_RS03565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMAL454_RS03585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMAL454_RS03590	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMAL454_RS03595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SMAL454_RS03605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMAL454_RS03610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SMAL454_RS03620	COG0739	heme binding
SMAL454_RS03625	COG0653	protein targeting
SMAL454_RS03630	COG0494	nUDIX hydrolase
SMAL454_RS03640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMAL454_RS03650	COG3275	phosphorelay sensor kinase activity
SMAL454_RS03655	COG3279	Response regulator of the LytR AlgR family
SMAL454_RS03675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMAL454_RS03680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMAL454_RS03695	COG1607	acyl-coa hydrolase
SMAL454_RS03700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMAL454_RS03730	COG4106	trans-aconitate 2-methyltransferase activity
SMAL454_RS03735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMAL454_RS03755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMAL454_RS03760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SMAL454_RS03765	COG0667	Aldo Keto reductase
SMAL454_RS03775	COG4771	TonB-dependent receptor
SMAL454_RS03795	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SMAL454_RS03800	COG4181	ATPase activity
SMAL454_RS03815	COG0642	Histidine kinase
SMAL454_RS03825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMAL454_RS03830	COG0861	Integral membrane protein TerC family
SMAL454_RS03835	COG2814	Major facilitator Superfamily
SMAL454_RS03840	COG1704	LemA family
SMAL454_RS03855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMAL454_RS03860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMAL454_RS03870	COG3738	Protein conserved in bacteria
SMAL454_RS03875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMAL454_RS03880	COG2967	ApaG domain
SMAL454_RS03885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMAL454_RS03890	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMAL454_RS03895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMAL454_RS03900	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SMAL454_RS03910	COG2096	Adenosyltransferase
SMAL454_RS03920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMAL454_RS03925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMAL454_RS03930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMAL454_RS03935	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
SMAL454_RS03955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMAL454_RS03965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMAL454_RS03975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMAL454_RS03980	COG0583	DNA-binding transcription factor activity
SMAL454_RS03985	COG3634	alkyl hydroperoxide reductase activity
SMAL454_RS04025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMAL454_RS04025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMAL454_RS04040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SMAL454_RS04065	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SMAL454_RS04080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMAL454_RS04085	COG1404	Belongs to the peptidase S8 family
SMAL454_RS04105	COG1295	ribonuclease BN
SMAL454_RS04110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMAL454_RS04125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMAL454_RS04130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMAL454_RS04145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMAL454_RS04155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMAL454_RS04160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMAL454_RS04165	COG0193	aminoacyl-tRNA hydrolase activity
SMAL454_RS04170	COG0012	GTP binding
SMAL454_RS04180	COG2197	response regulator
SMAL454_RS04185	COG0784	Response regulator, receiver
SMAL454_RS04185	COG2205	protein histidine kinase activity
SMAL454_RS04190	COG2199	diguanylate cyclase activity
SMAL454_RS04190	COG2203	Gaf domain
SMAL454_RS04190	COG2200	EAL domain
SMAL454_RS04195	COG0784	Response regulator, receiver
SMAL454_RS04195	COG2205	protein histidine kinase activity
SMAL454_RS04200	COG4206	TonB-dependent receptor
SMAL454_RS04205	COG4242	Belongs to the peptidase S51 family
SMAL454_RS04230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMAL454_RS04245	COG0250	Participates in transcription elongation, termination and antitermination
SMAL454_RS04250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMAL454_RS04255	COG0081	regulation of translation
SMAL454_RS04260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMAL454_RS04265	COG0222	ribosome binding
SMAL454_RS04270	COG0085	RNA polymerase activity
SMAL454_RS04275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMAL454_RS04280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMAL454_RS04285	COG0049	tRNA binding
SMAL454_RS04290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMAL454_RS04295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMAL454_RS04300	COG0051	transcription antitermination factor activity, RNA binding
SMAL454_RS04305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMAL454_RS04310	COG0088	Forms part of the polypeptide exit tunnel
SMAL454_RS04315	COG0089	rRNA binding
SMAL454_RS04320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMAL454_RS04325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMAL454_RS04330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMAL454_RS04335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMAL454_RS04340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMAL454_RS04345	COG0255	Belongs to the universal ribosomal protein uL29 family
SMAL454_RS04350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMAL454_RS04355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMAL454_RS04360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMAL454_RS04365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMAL454_RS04370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMAL454_RS04375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMAL454_RS04380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMAL454_RS04385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMAL454_RS04390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMAL454_RS04395	COG1841	ribosomal large subunit assembly
SMAL454_RS04400	COG0200	Binds to the 23S rRNA
SMAL454_RS04405	COG0201	protein transport
SMAL454_RS04410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMAL454_RS04415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMAL454_RS04420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMAL454_RS04425	COG0202	RNA polymerase activity
SMAL454_RS04430	COG0203	ribosomal protein L17
SMAL454_RS04445	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMAL454_RS04455	COG0154	amidase activity
SMAL454_RS04470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMAL454_RS04475	COG0039	L-malate dehydrogenase activity
SMAL454_RS04480	COG0564	pseudouridine synthase activity
SMAL454_RS04490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMAL454_RS04505	COG0625	glutathione transferase activity
SMAL454_RS04515	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMAL454_RS04515	COG1902	pentaerythritol trinitrate reductase activity
SMAL454_RS04520	COG2364	Membrane
SMAL454_RS04525	COG0604	alcohol dehydrogenase
SMAL454_RS04540	COG1187	pseudouridine synthase activity
SMAL454_RS04560	COG1063	alcohol dehydrogenase
SMAL454_RS04570	COG0406	alpha-ribazole phosphatase activity
SMAL454_RS04575	COG0285	dihydrofolate synthase activity
SMAL454_RS04595	COG2833	Protein of unknown function (DUF455)
SMAL454_RS04605	COG3291	Pkd domain containing protein
SMAL454_RS04610	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMAL454_RS04620	COG0438	transferase activity, transferring glycosyl groups
SMAL454_RS04635	COG0248	Ppx GppA phosphatase
SMAL454_RS04640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMAL454_RS04655	COG4783	chaperone-mediated protein folding
SMAL454_RS04670	COG0473	3-isopropylmalate dehydrogenase activity
SMAL454_RS04735	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SMAL454_RS04775	COG0592	DNA-directed DNA polymerase activity
SMAL454_RS04800	COG2204	response regulator
SMAL454_RS04965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMAL454_RS04965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMAL454_RS05030	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMAL454_RS05035	COG0740	serine-type endopeptidase activity
SMAL454_RS05040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMAL454_RS05080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMAL454_RS05085	COG1388	LysM domain
SMAL454_RS05085	COG3942	CHAP domain
SMAL454_RS05090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMAL454_RS05100	COG0328	RNA-DNA hybrid ribonuclease activity
SMAL454_RS05105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMAL454_RS05110	COG0631	protein serine/threonine phosphatase activity
SMAL454_RS05130	COG0859	PFAM glycosyl transferase family 9
SMAL454_RS05135	COG3642	lipopolysaccharide core region biosynthetic process
SMAL454_RS05140	COG1234	tRNA 3'-trailer cleavage
SMAL454_RS05155	COG2076	Multidrug Resistance protein
SMAL454_RS05185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMAL454_RS05195	COG0537	adenosine 5'-monophosphoramidase activity
SMAL454_RS05215	COG0714	Associated with various cellular activities
SMAL454_RS05230	COG1399	metal-binding, possibly nucleic acid-binding protein
SMAL454_RS05235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMAL454_RS05240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMAL454_RS05250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMAL454_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS05265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMAL454_RS05270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMAL454_RS05275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMAL454_RS05280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMAL454_RS05490	COG4774	siderophore transport
SMAL454_RS05500	COG2223	nitrite transmembrane transporter activity
SMAL454_RS05515	COG2226	methyltransferase
SMAL454_RS05525	COG0583	DNA-binding transcription factor activity
SMAL454_RS05530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMAL454_RS05535	COG0697	spore germination
SMAL454_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS05545	COG0583	DNA-binding transcription factor activity
SMAL454_RS05555	COG0477	Major facilitator Superfamily
SMAL454_RS05590	COG0583	DNA-binding transcription factor activity
SMAL454_RS05600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMAL454_RS05615	COG0667	Aldo Keto reductase
SMAL454_RS05635	COG0519	Catalyzes the synthesis of GMP from XMP
SMAL454_RS05640	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SMAL454_RS05645	COG1678	Uncharacterized ACR, COG1678
SMAL454_RS05650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMAL454_RS05655	COG0540	Belongs to the ATCase OTCase family
SMAL454_RS05675	COG2239	Acts as a magnesium transporter
SMAL454_RS05680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMAL454_RS05695	COG1660	Displays ATPase and GTPase activities
SMAL454_RS05700	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SMAL454_RS05705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMAL454_RS05710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMAL454_RS05720	COG1137	ATPase activity
SMAL454_RS05735	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SMAL454_RS05750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMAL454_RS05770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMAL454_RS05790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMAL454_RS05800	COG0628	permease
SMAL454_RS05810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMAL454_RS05820	COG2261	transglycosylase associated protein
SMAL454_RS05830	COG1555	photosystem II stabilization
SMAL454_RS05850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SMAL454_RS05855	COG1477	protein flavinylation
SMAL454_RS05875	COG4771	TonB-dependent receptor
SMAL454_RS05885	COG3128	pkhd-type hydroxylase
SMAL454_RS05895	COG4774	siderophore transport
SMAL454_RS05905	COG2146	nitrite reductase [NAD(P)H] activity
SMAL454_RS05920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMAL454_RS05925	COG0719	Fe-S assembly protein
SMAL454_RS05930	COG0396	ATPase activity
SMAL454_RS05940	COG0719	Fe-S assembly protein
SMAL454_RS05945	COG1959	2 iron, 2 sulfur cluster binding
SMAL454_RS05955	COG0693	protein deglycase activity
SMAL454_RS05980	COG1764	response to oxidative stress
SMAL454_RS05985	COG0384	phenazine biosynthesis protein PhzF
SMAL454_RS05990	COG0384	phenazine biosynthesis protein PhzF
SMAL454_RS05995	COG0527	aspartate kinase activity
SMAL454_RS06020	COG0142	geranyltranstransferase activity
SMAL454_RS06025	COG0366	Alpha amylase catalytic
SMAL454_RS06035	COG1082	Xylose isomerase domain protein TIM barrel
SMAL454_RS06045	COG2190	(PTS) system
SMAL454_RS06045	COG2211	Major facilitator Superfamily
SMAL454_RS06075	COG1131	(ABC) transporter
SMAL454_RS06085	COG0629	single-stranded DNA binding
SMAL454_RS06120	COG0673	inositol 2-dehydrogenase activity
SMAL454_RS06125	COG2211	Major facilitator Superfamily
SMAL454_RS06135	COG1609	Transcriptional regulator
SMAL454_RS06175	COG0640	Transcriptional regulator
SMAL454_RS06190	COG3655	Transcriptional regulator
SMAL454_RS06195	COG1253	flavin adenine dinucleotide binding
SMAL454_RS06200	COG1408	metallophosphoesterase
SMAL454_RS06205	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SMAL454_RS06225	COG2259	Doxx family
SMAL454_RS06255	COG0477	Major facilitator Superfamily
SMAL454_RS06270	COG1802	Transcriptional regulator
SMAL454_RS06305	COG3052	prosthetic group binding
SMAL454_RS06320	COG0579	oxidoreductase
SMAL454_RS06345	COG3104	oligopeptide transport
SMAL454_RS06360	COG1297	OPT oligopeptide transporter protein
SMAL454_RS06365	COG0823	Involved in the tonB-independent uptake of proteins
SMAL454_RS06365	COG1506	peptidase
SMAL454_RS06380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SMAL454_RS06385	COG2894	cell division
SMAL454_RS06400	COG4585	Histidine kinase
SMAL454_RS06405	COG2197	response regulator
SMAL454_RS06445	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMAL454_RS06455	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SMAL454_RS06465	COG1595	DNA-templated transcription, initiation
SMAL454_RS06475	COG1946	Acyl-CoA thioesterase
SMAL454_RS06495	COG0824	Thioesterase
SMAL454_RS06500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMAL454_RS06505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMAL454_RS06510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMAL454_RS06515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMAL454_RS06520	COG0268	Binds directly to 16S ribosomal RNA
SMAL454_RS06525	COG0728	peptidoglycan biosynthetic process
SMAL454_RS06530	COG0196	riboflavin kinase activity
SMAL454_RS06535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMAL454_RS06545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMAL454_RS06570	COG4206	TonB-dependent receptor
SMAL454_RS06590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMAL454_RS06600	COG3209	COG3209 Rhs family protein
SMAL454_RS06635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMAL454_RS06640	COG1845	cytochrome c oxidase, subunit III
SMAL454_RS06645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SMAL454_RS06660	COG0326	Molecular chaperone. Has ATPase activity
SMAL454_RS06680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMAL454_RS06700	COG0228	four-way junction DNA binding
SMAL454_RS06705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMAL454_RS06710	COG0336	Belongs to the RNA methyltransferase TrmD family
SMAL454_RS06715	COG0335	large ribosomal subunit rRNA binding
SMAL454_RS06735	COG0534	Mate efflux family protein
SMAL454_RS06760	COG0753	catalase activity
SMAL454_RS06785	COG2831	hemolysin activation secretion protein
SMAL454_RS06790	COG3210	domain, Protein
SMAL454_RS06805	COG0840	transmembrane signaling receptor activity
SMAL454_RS06825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL454_RS06845	COG0024	Methionine aminopeptidase
SMAL454_RS06870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMAL454_RS06895	COG1647	Serine aminopeptidase, S33
SMAL454_RS06920	COG2814	Major facilitator Superfamily
SMAL454_RS06925	COG3706	GGDEF domain
SMAL454_RS06950	COG0588	phosphoglycerate mutase activity
SMAL454_RS06960	COG3590	peptidase
SMAL454_RS06970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMAL454_RS06980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SMAL454_RS06985	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS06990	COG2205	protein histidine kinase activity
SMAL454_RS06995	COG4452	Inner membrane protein CreD
SMAL454_RS07010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMAL454_RS07015	COG0735	belongs to the Fur family
SMAL454_RS07055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMAL454_RS07100	COG5002	protein histidine kinase activity
SMAL454_RS07100	COG5001	Diguanylate cyclase
SMAL454_RS07110	COG1187	pseudouridine synthase activity
SMAL454_RS07140	COG1132	(ABC) transporter
SMAL454_RS07190	COG1695	Transcriptional regulator
SMAL454_RS07210	COG1981	membrane
SMAL454_RS07215	COG0825	malonyl-CoA metabolic process
SMAL454_RS07240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMAL454_RS07260	COG0750	zinc metalloprotease
SMAL454_RS07265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMAL454_RS07270	COG0575	Belongs to the CDS family
SMAL454_RS07275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMAL454_RS07280	COG0233	cytoplasmic translational termination
SMAL454_RS07285	COG0528	UMP kinase activity
SMAL454_RS07295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMAL454_RS07300	COG0052	Belongs to the universal ribosomal protein uS2 family
SMAL454_RS07320	COG3188	usher protein
SMAL454_RS07340	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SMAL454_RS07350	COG1393	Belongs to the ArsC family
SMAL454_RS07355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMAL454_RS07360	COG0367	asparagine synthase
SMAL454_RS07365	COG0475	glutathione-regulated potassium exporter activity
SMAL454_RS07400	COG1566	PFAM secretion protein HlyD family protein
SMAL454_RS07405	COG2814	Major facilitator Superfamily
SMAL454_RS07420	COG0583	DNA-binding transcription factor activity
SMAL454_RS07440	COG0557	exoribonuclease II activity
SMAL454_RS07450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMAL454_RS07455	COG1538	Outer membrane efflux protein
SMAL454_RS07460	COG0577	efflux transmembrane transporter activity
SMAL454_RS07460	COG1136	(ABC) transporter
SMAL454_RS07465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL454_RS07485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMAL454_RS07490	COG2259	Doxx family
SMAL454_RS07500	COG3220	belongs to the UPF0276 family
SMAL454_RS07510	COG0704	Plays a role in the regulation of phosphate uptake
SMAL454_RS07520	COG0581	inorganic phosphate transmembrane transporter activity
SMAL454_RS07525	COG0573	inorganic phosphate transmembrane transporter activity
SMAL454_RS07530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMAL454_RS07535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMAL454_RS07545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMAL454_RS07555	COG1024	Enoyl-CoA hydratase
SMAL454_RS07565	COG0494	nUDIX hydrolase
SMAL454_RS07585	COG0116	Belongs to the methyltransferase superfamily
SMAL454_RS07585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMAL454_RS07605	COG2733	membrane
SMAL454_RS07615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMAL454_RS07620	COG1012	belongs to the aldehyde dehydrogenase family
SMAL454_RS07630	COG0477	Major facilitator Superfamily
SMAL454_RS07635	COG2703	oxygen carrier activity
SMAL454_RS07655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMAL454_RS07660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMAL454_RS07665	COG0174	glutamine synthetase
SMAL454_RS07675	COG2072	flavoprotein involved in K transport
SMAL454_RS07680	COG3842	ATPase activity
SMAL454_RS07685	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMAL454_RS07690	COG1177	transmembrane transport
SMAL454_RS07695	COG1012	belongs to the aldehyde dehydrogenase family
SMAL454_RS07710	COG4535	Mg2 and Co2 transporter CorC
SMAL454_RS07730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMAL454_RS07735	COG1702	phosphate starvation-inducible protein PhoH
SMAL454_RS07745	COG1131	(ABC) transporter
SMAL454_RS07750	COG0842	Transport permease protein
SMAL454_RS07755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMAL454_RS07770	COG0741	lytic transglycosylase activity
SMAL454_RS07775	COG0723	plastoquinol--plastocyanin reductase activity
SMAL454_RS07780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMAL454_RS07785	COG2857	Cytochrome c1
SMAL454_RS07790	COG0625	glutathione transferase activity
SMAL454_RS07795	COG2969	positive regulation of protein catabolic process
SMAL454_RS07830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMAL454_RS07840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SMAL454_RS07900	COG0556	nucleotide-excision repair
SMAL454_RS07940	COG3713	MltA-interacting MipA family protein
SMAL454_RS07960	COG0811	peptide transport
SMAL454_RS07975	COG1663	tetraacyldisaccharide 4'-kinase activity
SMAL454_RS07980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMAL454_RS07985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMAL454_RS07995	COG0322	excinuclease ABC activity
SMAL454_RS08030	COG1136	(ABC) transporter
SMAL454_RS08030	COG0577	efflux transmembrane transporter activity
SMAL454_RS08090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMAL454_RS08115	COG0583	DNA-binding transcription factor activity
SMAL454_RS08135	COG1917	Cupin 2, conserved barrel domain protein
SMAL454_RS08135	COG4977	sequence-specific DNA binding
SMAL454_RS08140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMAL454_RS08160	COG0348	domain, Protein
SMAL454_RS08175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMAL454_RS08190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SMAL454_RS08195	COG0069	glutamate synthase activity
SMAL454_RS08220	COG1054	Belongs to the UPF0176 family
SMAL454_RS08225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMAL454_RS08240	COG1253	flavin adenine dinucleotide binding
SMAL454_RS08260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMAL454_RS08275	COG0504	CTP synthase activity
SMAL454_RS08280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMAL454_RS08295	COG0148	phosphopyruvate hydratase activity
SMAL454_RS08300	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SMAL454_RS08305	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMAL454_RS08310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMAL454_RS08320	COG2840	Smr protein MutS2
SMAL454_RS08325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMAL454_RS08330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMAL454_RS08355	COG1534	Rna-binding protein
SMAL454_RS08360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SMAL454_RS08365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMAL454_RS08375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMAL454_RS08380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMAL454_RS08385	COG1923	regulation of RNA biosynthetic process
SMAL454_RS08390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMAL454_RS08395	COG1546	Belongs to the CinA family
SMAL454_RS08400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMAL454_RS08405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMAL454_RS08410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMAL454_RS08415	COG2137	regulation of response to DNA damage stimulus
SMAL454_RS08420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMAL454_RS08425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SMAL454_RS08475	COG3540	Alkaline phosphatase
SMAL454_RS08490	COG3258	Cytochrome c
SMAL454_RS08505	COG2223	nitrite transmembrane transporter activity
SMAL454_RS08520	COG1741	Belongs to the pirin family
SMAL454_RS08525	COG0583	DNA-binding transcription factor activity
SMAL454_RS08550	COG0351	phosphomethylpyrimidine kinase
SMAL454_RS08550	COG0352	thiamine-phosphate diphosphorylase activity
SMAL454_RS08565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SMAL454_RS08570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMAL454_RS08580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMAL454_RS08590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SMAL454_RS08595	COG0477	Major facilitator Superfamily
SMAL454_RS08605	COG0617	tRNA 3'-terminal CCA addition
SMAL454_RS08610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMAL454_RS08615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMAL454_RS08620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMAL454_RS08630	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMAL454_RS08635	COG0166	Belongs to the GPI family
SMAL454_RS08640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SMAL454_RS08650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMAL454_RS08655	COG0671	phosphoesterase, PA-phosphatase related
SMAL454_RS08665	COG0800	Aldolase
SMAL454_RS08670	COG0129	dihydroxy-acid dehydratase activity
SMAL454_RS08680	COG0837	glucose binding
SMAL454_RS08690	COG3842	ATPase activity
SMAL454_RS08705	COG2009	succinate dehydrogenase
SMAL454_RS08710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SMAL454_RS08715	COG1053	succinate dehydrogenase
SMAL454_RS08735	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMAL454_RS08750	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SMAL454_RS08760	COG0552	protein localization to endoplasmic reticulum
SMAL454_RS08775	COG0742	ribosomal rna small subunit methyltransferase
SMAL454_RS08780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMAL454_RS08790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMAL454_RS08795	COG0405	Gamma-glutamyltransferase
SMAL454_RS08800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMAL454_RS08820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMAL454_RS08840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMAL454_RS08850	COG0415	Belongs to the DNA photolyase family
SMAL454_RS08855	COG2885	chlorophyll binding
SMAL454_RS08860	COG0583	DNA-binding transcription factor activity
SMAL454_RS08960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMAL454_RS08970	COG2914	Belongs to the UPF0125 (RnfH) family
SMAL454_RS08975	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMAL454_RS08980	COG0735	belongs to the Fur family
SMAL454_RS08990	COG0583	DNA-binding transcription factor activity
SMAL454_RS08995	COG0497	DNA recombination
SMAL454_RS09000	COG1420	regulation of RNA biosynthetic process
SMAL454_RS09005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMAL454_RS09010	COG0443	Heat shock 70 kDa protein
SMAL454_RS09015	COG0484	heat shock protein binding
SMAL454_RS09020	COG2207	Transcriptional regulator
SMAL454_RS09025	COG2223	nitrite transmembrane transporter activity
SMAL454_RS09030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
SMAL454_RS09045	COG1132	(ABC) transporter
SMAL454_RS09075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMAL454_RS09080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMAL454_RS09085	COG0343	queuine tRNA-ribosyltransferase activity
SMAL454_RS09090	COG1862	Preprotein translocase
SMAL454_RS09100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMAL454_RS09105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMAL454_RS09115	COG2081	HI0933 family
SMAL454_RS09120	COG4681	YaeQ
SMAL454_RS09125	COG0564	pseudouridine synthase activity
SMAL454_RS09140	COG0625	glutathione transferase activity
SMAL454_RS09145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SMAL454_RS09150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMAL454_RS09155	COG0513	Belongs to the DEAD box helicase family
SMAL454_RS09165	COG0583	DNA-binding transcription factor activity
SMAL454_RS09170	COG0488	(ABC) transporter
SMAL454_RS09195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL454_RS09215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMAL454_RS09220	COG2957	Belongs to the agmatine deiminase family
SMAL454_RS09230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMAL454_RS09235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMAL454_RS09245	COG0776	regulation of translation
SMAL454_RS09255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SMAL454_RS09260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMAL454_RS09270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMAL454_RS09275	COG0183	Belongs to the thiolase family
SMAL454_RS09280	COG1024	Enoyl-CoA hydratase
SMAL454_RS09280	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMAL454_RS09290	COG0105	UTP biosynthetic process
SMAL454_RS09295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMAL454_RS09305	COG1426	Protein conserved in bacteria
SMAL454_RS09315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMAL454_RS09320	COG1160	GTP binding
SMAL454_RS09340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMAL454_RS09345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMAL454_RS09345	COG0475	glutathione-regulated potassium exporter activity
SMAL454_RS09350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMAL454_RS09360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMAL454_RS09360	COG0519	Catalyzes the synthesis of GMP from XMP
SMAL454_RS09395	COG0583	DNA-binding transcription factor activity
SMAL454_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS09420	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS09445	COG0640	Transcriptional regulator
SMAL454_RS09460	COG4716	Myosin-crossreactive antigen
SMAL454_RS09495	COG0431	NADPH-dependent FMN reductase
SMAL454_RS09505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMAL454_RS09510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMAL454_RS09515	COG1473	amidohydrolase
SMAL454_RS09525	COG1126	abc transporter atp-binding protein
SMAL454_RS09535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMAL454_RS09560	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SMAL454_RS09570	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS09580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMAL454_RS09600	COG1309	transcriptional regulator
SMAL454_RS09615	COG0697	spore germination
SMAL454_RS09620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMAL454_RS09625	COG0167	dihydroorotate dehydrogenase activity
SMAL454_RS09640	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS09645	COG1012	belongs to the aldehyde dehydrogenase family
SMAL454_RS09790	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS09795	COG0784	Response regulator, receiver
SMAL454_RS09795	COG4191	Histidine kinase
SMAL454_RS09800	COG4999	Histidine kinase
SMAL454_RS09800	COG3437	response regulator, receiver
SMAL454_RS09800	COG3850	Histidine kinase
SMAL454_RS09800	COG2205	protein histidine kinase activity
SMAL454_RS09805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMAL454_RS09815	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS09825	COG0640	Transcriptional regulator
SMAL454_RS09865	COG0527	aspartate kinase activity
SMAL454_RS09865	COG0460	homoserine dehydrogenase
SMAL454_RS09870	COG0083	homoserine kinase activity
SMAL454_RS09880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMAL454_RS09885	COG0124	histidyl-tRNA synthetase
SMAL454_RS09895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMAL454_RS09900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMAL454_RS09905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMAL454_RS09910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMAL454_RS09910	COG0131	Imidazoleglycerol-phosphate dehydratase
SMAL454_RS09915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMAL454_RS09920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMAL454_RS09925	COG0107	imidazoleglycerol-phosphate synthase activity
SMAL454_RS09930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMAL454_RS09930	COG0140	phosphoribosyl-ATP diphosphatase activity
SMAL454_RS09955	COG3142	Participates in the control of copper homeostasis
SMAL454_RS09970	COG0789	Transcriptional regulator
SMAL454_RS09985	COG3537	Alpha-1,2-mannosidase
SMAL454_RS09990	COG1609	Transcriptional regulator
SMAL454_RS10000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMAL454_RS10015	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SMAL454_RS10020	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SMAL454_RS10025	COG0235	Class ii aldolase
SMAL454_RS10040	COG0531	amino acid
SMAL454_RS10045	COG0531	amino acid
SMAL454_RS10055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMAL454_RS10060	COG0277	FAD linked oxidase domain protein
SMAL454_RS10075	COG2205	protein histidine kinase activity
SMAL454_RS10080	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS10085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL454_RS10105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMAL454_RS10150	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMAL454_RS10165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMAL454_RS10170	COG0505	Belongs to the CarA family
SMAL454_RS10175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMAL454_RS10180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMAL454_RS10195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMAL454_RS10200	COG4676	Protein conserved in bacteria
SMAL454_RS10215	COG3279	Response regulator of the LytR AlgR family
SMAL454_RS10230	COG1012	belongs to the aldehyde dehydrogenase family
SMAL454_RS10250	COG0784	Response regulator, receiver
SMAL454_RS10250	COG2198	Histidine kinase
SMAL454_RS10250	COG2205	protein histidine kinase activity
SMAL454_RS10255	COG1024	Enoyl-CoA hydratase
SMAL454_RS10260	COG0318	PFAM AMP-dependent synthetase and ligase
SMAL454_RS10265	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMAL454_RS10270	COG1012	belongs to the aldehyde dehydrogenase family
SMAL454_RS10275	COG1309	transcriptional regulator
SMAL454_RS10280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMAL454_RS10325	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SMAL454_RS10335	COG0840	transmembrane signaling receptor activity
SMAL454_RS10340	COG0840	transmembrane signaling receptor activity
SMAL454_RS10350	COG0835	chemotaxis
SMAL454_RS10355	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SMAL454_RS10360	COG0840	transmembrane signaling receptor activity
SMAL454_RS10370	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS10380	COG0835	chemotaxis
SMAL454_RS10390	COG1360	Flagellar Motor Protein
SMAL454_RS10395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SMAL454_RS10400	COG0643	Histidine kinase
SMAL454_RS10400	COG2198	Histidine kinase
SMAL454_RS10400	COG0784	Response regulator, receiver
SMAL454_RS10405	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SMAL454_RS10430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMAL454_RS10435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMAL454_RS10455	COG1987	bacterial-type flagellum assembly
SMAL454_RS10465	COG3190	flagellar
SMAL454_RS10515	COG1677	Flagellar hook-basal body complex protein FliE
SMAL454_RS10540	COG2197	response regulator
SMAL454_RS10560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SMAL454_RS10570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMAL454_RS10600	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SMAL454_RS10610	COG4787	bacterial-type flagellum-dependent cell motility
SMAL454_RS10625	COG1558	bacterial-type flagellum-dependent cell motility
SMAL454_RS10630	COG1815	bacterial-type flagellum-dependent cell motility
SMAL454_RS10635	COG0784	Response regulator, receiver
SMAL454_RS10635	COG0835	chemotaxis
SMAL454_RS10655	COG5002	protein histidine kinase activity
SMAL454_RS10690	COG2915	High frequency lysogenization protein hflD homolog
SMAL454_RS10695	COG0482	sulfurtransferase activity
SMAL454_RS10710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMAL454_RS10720	COG0542	response to heat
SMAL454_RS10750	COG0492	ferredoxin-NADP+ reductase activity
SMAL454_RS10755	COG1674	ftsk spoiiie
SMAL454_RS10770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMAL454_RS10785	COG2819	hydrolase of the alpha beta superfamily
SMAL454_RS10795	COG4558	Periplasmic binding protein
SMAL454_RS10800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMAL454_RS10805	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMAL454_RS10815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMAL454_RS10860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMAL454_RS10870	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SMAL454_RS10885	COG1595	DNA-templated transcription, initiation
SMAL454_RS10905	COG0784	Response regulator, receiver
SMAL454_RS10910	COG4251	negative regulation of phosphorylation
SMAL454_RS10920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SMAL454_RS10995	COG0084	hydrolase, TatD family'
SMAL454_RS11000	COG2801	Transposase and inactivated derivatives
SMAL454_RS11060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMAL454_RS11070	COG0542	response to heat
SMAL454_RS11075	COG0071	Belongs to the small heat shock protein (HSP20) family
SMAL454_RS11145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMAL454_RS11150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMAL454_RS11155	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMAL454_RS11160	COG2080	2 iron, 2 sulfur cluster binding
SMAL454_RS11175	COG1309	transcriptional regulator
SMAL454_RS11235	COG3685	Protein conserved in bacteria
SMAL454_RS11260	COG3546	catalase activity
SMAL454_RS11265	COG3685	Protein conserved in bacteria
SMAL454_RS11295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMAL454_RS11315	COG1063	alcohol dehydrogenase
SMAL454_RS11345	COG1609	Transcriptional regulator
SMAL454_RS11350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMAL454_RS11350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMAL454_RS11355	COG1105	Belongs to the carbohydrate kinase PfkB family
SMAL454_RS11360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMAL454_RS11360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMAL454_RS11375	COG1733	regulation of RNA biosynthetic process
SMAL454_RS11380	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SMAL454_RS11395	COG4771	TonB-dependent receptor
SMAL454_RS11405	COG1609	Transcriptional regulator
SMAL454_RS11410	COG1472	Belongs to the glycosyl hydrolase 3 family
SMAL454_RS11425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMAL454_RS11440	COG2828	Protein conserved in bacteria
SMAL454_RS11445	COG0583	DNA-binding transcription factor activity
SMAL454_RS11470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMAL454_RS11475	COG0583	DNA-binding transcription factor activity
SMAL454_RS11505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMAL454_RS11530	COG0642	Histidine kinase
SMAL454_RS11540	COG0318	PFAM AMP-dependent synthetase and ligase
SMAL454_RS11555	COG2186	Transcriptional regulator
SMAL454_RS11575	COG2271	Major facilitator Superfamily
SMAL454_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS11590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMAL454_RS11615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMAL454_RS11635	COG0583	DNA-binding transcription factor activity
SMAL454_RS11660	COG2204	response regulator
SMAL454_RS11735	COG0708	Exodeoxyribonuclease III
SMAL454_RS11740	COG0366	Alpha amylase catalytic
SMAL454_RS11745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMAL454_RS11755	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS11765	COG1136	(ABC) transporter
SMAL454_RS11765	COG0577	efflux transmembrane transporter activity
SMAL454_RS11770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL454_RS11780	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS11785	COG2205	protein histidine kinase activity
SMAL454_RS11795	COG3214	Protein conserved in bacteria
SMAL454_RS11805	COG4774	siderophore transport
SMAL454_RS11825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMAL454_RS11830	COG1285	pathogenesis
SMAL454_RS11835	COG4191	Histidine kinase
SMAL454_RS11840	COG4566	intracellular signal transduction
SMAL454_RS11895	COG0243	molybdopterin cofactor binding
SMAL454_RS11920	COG0477	Major facilitator Superfamily
SMAL454_RS11945	COG1136	(ABC) transporter
SMAL454_RS11960	COG0583	DNA-binding transcription factor activity
SMAL454_RS11965	COG0656	L-ascorbic acid biosynthetic process
SMAL454_RS11985	COG0583	DNA-binding transcription factor activity
SMAL454_RS11990	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS12020	COG3537	Alpha-1,2-mannosidase
SMAL454_RS12035	COG0477	Major facilitator Superfamily
SMAL454_RS12055	COG3920	Histidine kinase
SMAL454_RS12055	COG2202	Pas domain
SMAL454_RS12100	COG1335	isochorismatase
SMAL454_RS12105	COG1335	isochorismatase
SMAL454_RS12135	COG0811	peptide transport
SMAL454_RS12275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMAL454_RS12280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMAL454_RS12290	COG0840	transmembrane signaling receptor activity
SMAL454_RS12295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SMAL454_RS12300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SMAL454_RS12305	COG4149	molybdate abc transporter
SMAL454_RS12310	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMAL454_RS12315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMAL454_RS12330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMAL454_RS12335	COG2181	nitrate reductase activity
SMAL454_RS12340	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SMAL454_RS12345	COG1140	nitrate reductase beta subunit
SMAL454_RS12350	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SMAL454_RS12355	COG2223	nitrite transmembrane transporter activity
SMAL454_RS12365	COG0746	molybdenum cofactor guanylyltransferase activity
SMAL454_RS12370	COG0314	molybdopterin synthase activity
SMAL454_RS12380	COG0303	'Molybdopterin
SMAL454_RS12385	COG0315	cyclic pyranopterin monophosphate synthase activity
SMAL454_RS12385	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMAL454_RS12390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMAL454_RS12430	COG3209	COG3209 Rhs family protein
SMAL454_RS12440	COG2207	Transcriptional regulator
SMAL454_RS12455	COG1566	PFAM secretion protein HlyD family protein
SMAL454_RS12480	COG2205	protein histidine kinase activity
SMAL454_RS12490	COG2194	sulfuric ester hydrolase activity
SMAL454_RS12510	COG2885	chlorophyll binding
SMAL454_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS12530	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SMAL454_RS12530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMAL454_RS12535	COG1535	isochorismatase
SMAL454_RS12535	COG3433	isochorismatase activity
SMAL454_RS12540	COG3433	isochorismatase activity
SMAL454_RS12540	COG1535	isochorismatase
SMAL454_RS12545	COG1021	2,3-dihydroxybenzoate-AMP ligase
SMAL454_RS12550	COG1169	isochorismate synthase
SMAL454_RS12560	COG2409	Drug exporters of the RND superfamily
SMAL454_RS12565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMAL454_RS12630	COG1914	H( )-stimulated, divalent metal cation uptake system
SMAL454_RS12645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMAL454_RS12650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMAL454_RS12655	COG3321	synthase
SMAL454_RS12655	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS12655	COG0604	alcohol dehydrogenase
SMAL454_RS12660	COG4206	TonB-dependent receptor
SMAL454_RS12665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMAL454_RS12710	COG4772	TonB-dependent receptor
SMAL454_RS12730	COG2226	methyltransferase
SMAL454_RS12775	COG4964	Belongs to the GSP D family
SMAL454_RS12830	COG2814	Major facilitator Superfamily
SMAL454_RS12840	COG1228	amidohydrolase
SMAL454_RS12850	COG1335	isochorismatase
SMAL454_RS12865	COG3850	Histidine kinase
SMAL454_RS12870	COG2197	response regulator
SMAL454_RS12875	COG2814	Major facilitator Superfamily
SMAL454_RS12885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMAL454_RS12895	COG0583	DNA-binding transcription factor activity
SMAL454_RS12910	COG3161	chorismate lyase activity
SMAL454_RS12950	COG0277	FAD linked oxidase domain protein
SMAL454_RS12955	COG1304	FMN binding
SMAL454_RS12960	COG2186	Transcriptional regulator
SMAL454_RS12970	COG1285	pathogenesis
SMAL454_RS12995	COG2814	Major facilitator Superfamily
SMAL454_RS13050	COG0587	DNA-directed DNA polymerase activity
SMAL454_RS13065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMAL454_RS13070	COG0519	Catalyzes the synthesis of GMP from XMP
SMAL454_RS13070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMAL454_RS13085	COG1595	DNA-templated transcription, initiation
SMAL454_RS13095	COG4206	TonB-dependent receptor
SMAL454_RS13095	COG1629	transport
SMAL454_RS13125	COG0531	amino acid
SMAL454_RS13140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMAL454_RS13150	COG0789	Transcriptional regulator
SMAL454_RS13235	COG5002	protein histidine kinase activity
SMAL454_RS13235	COG3447	MASE1 domain protein
SMAL454_RS13235	COG5001	Diguanylate cyclase
SMAL454_RS13240	COG2183	response to ionizing radiation
SMAL454_RS13255	COG1983	PspC domain protein
SMAL454_RS13265	COG3243	poly(R)-hydroxyalkanoic acid synthase
SMAL454_RS13280	COG0534	Mate efflux family protein
SMAL454_RS13300	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SMAL454_RS13310	COG0668	transmembrane transport
SMAL454_RS13315	COG1902	pentaerythritol trinitrate reductase activity
SMAL454_RS13325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SMAL454_RS13335	COG1733	regulation of RNA biosynthetic process
SMAL454_RS13340	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMAL454_RS13420	COG3702	type iv secretory pathway
SMAL454_RS13440	COG2948	multi-organism process
SMAL454_RS13450	COG3736	Type IV secretory pathway, component VirB8
SMAL454_RS13460	COG3505	Type IV secretory pathway VirD4
SMAL454_RS13475	COG2814	Major facilitator Superfamily
SMAL454_RS13480	COG0789	Transcriptional regulator
SMAL454_RS13510	COG4191	Histidine kinase
SMAL454_RS13510	COG0784	Response regulator, receiver
SMAL454_RS13525	COG4774	siderophore transport
SMAL454_RS13545	COG1733	regulation of RNA biosynthetic process
SMAL454_RS13550	COG0604	alcohol dehydrogenase
SMAL454_RS13570	COG3209	COG3209 Rhs family protein
SMAL454_RS13620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMAL454_RS13810	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMAL454_RS13825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMAL454_RS13835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMAL454_RS13890	COG0583	DNA-binding transcription factor activity
SMAL454_RS13895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMAL454_RS13900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMAL454_RS13915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMAL454_RS13920	COG0077	Prephenate dehydratase
SMAL454_RS13920	COG1605	Chorismate mutase
SMAL454_RS13925	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMAL454_RS13970	COG1228	amidohydrolase
SMAL454_RS13985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SMAL454_RS14035	COG2957	Belongs to the agmatine deiminase family
SMAL454_RS14040	COG0583	DNA-binding transcription factor activity
SMAL454_RS14090	COG2801	Transposase and inactivated derivatives
SMAL454_RS14090	COG3415	Transposase
SMAL454_RS14095	COG4993	Dehydrogenase
SMAL454_RS14105	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMAL454_RS14115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SMAL454_RS14125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMAL454_RS14130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMAL454_RS14145	COG0359	binds to the 23S rRNA
SMAL454_RS14150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMAL454_RS14155	COG0360	Binds together with S18 to 16S ribosomal RNA
SMAL454_RS14165	COG0316	Belongs to the HesB IscA family
SMAL454_RS14170	COG0017	Asparaginyl-tRNA synthetase
SMAL454_RS14190	COG0288	reversible hydration of carbon dioxide
SMAL454_RS14200	COG3844	kynureninase activity
SMAL454_RS14205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMAL454_RS14210	COG2925	Exonuclease
SMAL454_RS14240	COG2902	Dehydrogenase
SMAL454_RS14250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL454_RS14255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL454_RS14270	COG1960	acyl-CoA dehydrogenase activity
SMAL454_RS14275	COG2226	methyltransferase
SMAL454_RS14285	COG0646	methionine synthase
SMAL454_RS14285	COG1410	methionine synthase
SMAL454_RS14300	COG2900	Belongs to the SlyX family
SMAL454_RS14315	COG0386	Belongs to the glutathione peroxidase family
SMAL454_RS14325	COG1725	Transcriptional regulator
SMAL454_RS14330	COG1131	(ABC) transporter
SMAL454_RS14355	COG0114	fumarate hydratase activity
SMAL454_RS14375	COG0567	Dehydrogenase, E1 component
SMAL454_RS14400	COG3540	Alkaline phosphatase
SMAL454_RS14410	COG0305	Participates in initiation and elongation during chromosome replication
SMAL454_RS14430	COG0625	glutathione transferase activity
SMAL454_RS14450	COG0084	hydrolase, TatD family'
SMAL454_RS14455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMAL454_RS14490	COG0625	glutathione transferase activity
SMAL454_RS14505	COG1595	DNA-templated transcription, initiation
SMAL454_RS14510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMAL454_RS14525	COG0386	Belongs to the glutathione peroxidase family
SMAL454_RS14530	COG0339	signal peptide processing
SMAL454_RS14540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMAL454_RS14560	COG0705	Rhomboid family
SMAL454_RS14565	COG3104	oligopeptide transport
SMAL454_RS14575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMAL454_RS14580	COG4290	ribonuclease
SMAL454_RS14595	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SMAL454_RS14595	COG0316	Belongs to the HesB IscA family
SMAL454_RS14600	COG2154	pterin-4-alpha-carbinolamine dehydratase
SMAL454_RS14610	COG0428	transporter
SMAL454_RS14620	COG1530	ribonuclease E activity
SMAL454_RS14635	COG0395	ABC-type sugar transport system, permease component
SMAL454_RS14665	COG0271	Belongs to the BolA IbaG family
SMAL454_RS14670	COG2350	Protein conserved in bacteria
SMAL454_RS14675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMAL454_RS14680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMAL454_RS14685	COG1187	pseudouridine synthase activity
SMAL454_RS14695	COG2814	Major facilitator Superfamily
SMAL454_RS14715	COG0436	Aminotransferase
SMAL454_RS14720	COG4133	protoheme IX ABC transporter activity
SMAL454_RS14740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SMAL454_RS14755	COG3088	subunit of a heme lyase
SMAL454_RS14755	COG4235	cytochrome complex assembly
SMAL454_RS14765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMAL454_RS14775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SMAL454_RS14780	COG4988	ABC transporter
SMAL454_RS14790	COG1294	oxidase, subunit
SMAL454_RS14820	COG0726	polysaccharide deacetylase
SMAL454_RS14820	COG1649	PFAM Uncharacterised BCR, COG1649
SMAL454_RS14825	COG1215	transferase activity, transferring glycosyl groups
SMAL454_RS14835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMAL454_RS14850	COG0165	Argininosuccinate lyase
SMAL454_RS14855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMAL454_RS14865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMAL454_RS14870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMAL454_RS14875	COG0137	argininosuccinate synthase activity
SMAL454_RS14880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMAL454_RS14895	COG2166	iron-sulfur cluster assembly
SMAL454_RS14915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMAL454_RS14935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMAL454_RS14940	COG0402	S-adenosylhomocysteine deaminase activity
SMAL454_RS14945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMAL454_RS14950	COG1509	lysine 2,3-aminomutase activity
SMAL454_RS14975	COG0501	Belongs to the peptidase M48B family
SMAL454_RS14985	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS15005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMAL454_RS15010	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMAL454_RS15015	COG0802	atpase or kinase
SMAL454_RS15020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMAL454_RS15020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMAL454_RS15025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMAL454_RS15030	COG1570	exodeoxyribonuclease VII activity
SMAL454_RS15045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMAL454_RS15065	COG4771	TonB-dependent receptor
SMAL454_RS15085	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS15090	COG2169	Transcriptional regulator
SMAL454_RS15090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMAL454_RS15095	COG2130	NADP-dependent
SMAL454_RS15120	COG1960	acyl-CoA dehydrogenase activity
SMAL454_RS15130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMAL454_RS15165	COG2076	Multidrug Resistance protein
SMAL454_RS15170	COG5487	UPF0391 membrane protein
SMAL454_RS15175	COG1280	lysine exporter protein (LysE YggA)
SMAL454_RS15180	COG1794	racemase activity, acting on amino acids and derivatives
SMAL454_RS15215	COG0776	regulation of translation
SMAL454_RS15220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMAL454_RS15220	COG0072	phenylalanine-tRNA ligase activity
SMAL454_RS15225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMAL454_RS15230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMAL454_RS15235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMAL454_RS15240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMAL454_RS15245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMAL454_RS15275	COG1185	polyribonucleotide nucleotidyltransferase activity
SMAL454_RS15280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMAL454_RS15290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMAL454_RS15295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMAL454_RS15300	COG0195	Participates in both transcription termination and antitermination
SMAL454_RS15305	COG0779	Required for maturation of 30S ribosomal subunits
SMAL454_RS15320	COG1007	ATP synthesis coupled electron transport
SMAL454_RS15335	COG0713	ATP synthesis coupled electron transport
SMAL454_RS15345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAL454_RS15350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMAL454_RS15365	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SMAL454_RS15370	COG0649	NAD binding
SMAL454_RS15375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAL454_RS15380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAL454_RS15385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAL454_RS15400	COG0149	triose-phosphate isomerase activity
SMAL454_RS15410	COG3083	sulfuric ester hydrolase activity
SMAL454_RS15415	COG0438	transferase activity, transferring glycosyl groups
SMAL454_RS15420	COG0726	polysaccharide deacetylase
SMAL454_RS15425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMAL454_RS15430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMAL454_RS15435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMAL454_RS15440	COG0159	tryptophan synthase activity
SMAL454_RS15450	COG0133	tryptophan synthase activity
SMAL454_RS15470	COG0135	phosphoribosylanthranilate isomerase activity
SMAL454_RS15475	COG0101	tRNA pseudouridine synthase activity
SMAL454_RS15490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMAL454_RS15500	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMAL454_RS15505	COG2890	protein-(glutamine-N5) methyltransferase activity
SMAL454_RS15510	COG1999	signal sequence binding
SMAL454_RS15515	COG0688	phosphatidylethanolamine metabolic process
SMAL454_RS15530	COG0433	COG0433 Predicted ATPase
SMAL454_RS15535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMAL454_RS15545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMAL454_RS15550	COG0412	Dienelactone hydrolase
SMAL454_RS15565	COG0717	Belongs to the dCTP deaminase family
SMAL454_RS15570	COG0489	protein tyrosine kinase activity
SMAL454_RS15575	COG4771	TonB-dependent receptor
SMAL454_RS15585	COG3590	peptidase
SMAL454_RS15620	COG0697	spore germination
SMAL454_RS15630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMAL454_RS15635	COG2311	Membrane
SMAL454_RS15640	COG1047	Peptidyl-prolyl cis-trans
SMAL454_RS15645	COG0791	NLP P60 protein
SMAL454_RS15650	COG0791	NLP P60 protein
SMAL454_RS15655	COG1301	dicarboxylic acid transport
SMAL454_RS15675	COG1722	exodeoxyribonuclease VII activity
SMAL454_RS15680	COG0142	geranyltranstransferase activity
SMAL454_RS15690	COG0312	modulator of DNA gyrase
SMAL454_RS15695	COG3028	Belongs to the UPF0307 family
SMAL454_RS15700	COG0312	modulator of DNA gyrase
SMAL454_RS15720	COG2968	Membrane
SMAL454_RS15730	COG4771	TonB-dependent receptor
SMAL454_RS15745	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMAL454_RS15755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMAL454_RS15770	COG0495	leucyl-tRNA aminoacylation
SMAL454_RS15780	COG3118	belongs to the thioredoxin family
SMAL454_RS15790	COG2203	Gaf domain
SMAL454_RS15790	COG3706	GGDEF domain
SMAL454_RS15790	COG4251	negative regulation of phosphorylation
SMAL454_RS15790	COG5001	Diguanylate cyclase
SMAL454_RS15810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SMAL454_RS15820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMAL454_RS15825	COG0346	lactoylglutathione lyase activity
SMAL454_RS15835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMAL454_RS15835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMAL454_RS15845	COG2878	Part of a membrane complex involved in electron transport
SMAL454_RS15850	COG0251	oxidation-reduction process
SMAL454_RS15855	COG0392	lysyltransferase activity
SMAL454_RS15855	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMAL454_RS15885	COG2824	Alkylphosphonate utilization operon protein PhnA
SMAL454_RS15890	COG0443	Heat shock 70 kDa protein
SMAL454_RS15935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SMAL454_RS15940	COG3122	Protein conserved in bacteria
SMAL454_RS15945	COG1451	nucleotide metabolic process
SMAL454_RS15955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMAL454_RS15975	COG0183	Belongs to the thiolase family
SMAL454_RS15990	COG1960	acyl-CoA dehydrogenase activity
SMAL454_RS16000	COG1793	dna ligase
SMAL454_RS16005	COG1201	RNA secondary structure unwinding
SMAL454_RS16020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMAL454_RS16025	COG1278	Cold shock
SMAL454_RS16030	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMAL454_RS16035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SMAL454_RS16040	COG1472	Belongs to the glycosyl hydrolase 3 family
SMAL454_RS16045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMAL454_RS16050	COG2954	triphosphatase activity
SMAL454_RS16055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMAL454_RS16060	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS16065	COG1381	Involved in DNA repair and RecF pathway recombination
SMAL454_RS16070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMAL454_RS16085	COG0681	Belongs to the peptidase S26 family
SMAL454_RS16090	COG0481	GTPase activity
SMAL454_RS16095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMAL454_RS16115	COG1741	Belongs to the pirin family
SMAL454_RS16120	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMAL454_RS16130	COG1741	Belongs to the pirin family
SMAL454_RS16135	COG1966	Carbon starvation protein
SMAL454_RS16140	COG2879	small protein
SMAL454_RS16155	COG2205	protein histidine kinase activity
SMAL454_RS16195	COG2814	Major facilitator Superfamily
SMAL454_RS16200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMAL454_RS16200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMAL454_RS16210	COG1113	amino acid transport
SMAL454_RS16215	COG1917	Cupin 2, conserved barrel domain protein
SMAL454_RS16215	COG2207	Transcriptional regulator
SMAL454_RS16220	COG0753	catalase activity
SMAL454_RS16250	COG1376	ErfK ybiS ycfS ynhG family protein
SMAL454_RS16255	COG0739	heme binding
SMAL454_RS16265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMAL454_RS16275	COG0330	HflC and HflK could
SMAL454_RS16280	COG0330	HflC and HflK could
SMAL454_RS16285	COG0604	alcohol dehydrogenase
SMAL454_RS16300	COG0678	peroxiredoxin activity
SMAL454_RS16310	COG4953	penicillin-binding protein 1C
SMAL454_RS16315	COG2373	Large extracellular alpha-helical protein
SMAL454_RS16320	COG2079	MmgE PrpD family protein
SMAL454_RS16325	COG2828	Protein conserved in bacteria
SMAL454_RS16335	COG3609	addiction module antidote protein, CC2985 family
SMAL454_RS16355	COG3829	transcription factor binding
SMAL454_RS16380	COG0259	pyridoxamine-phosphate oxidase activity
SMAL454_RS16395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMAL454_RS16415	COG0477	Major facilitator Superfamily
SMAL454_RS16425	COG2198	Histidine kinase
SMAL454_RS16425	COG5002	protein histidine kinase activity
SMAL454_RS16425	COG0784	Response regulator, receiver
SMAL454_RS16440	COG3038	cytochrome b561
SMAL454_RS16455	COG1760	l-serine dehydratase
SMAL454_RS16460	COG2267	carboxylic ester hydrolase activity
SMAL454_RS16465	COG0460	homoserine dehydrogenase
SMAL454_RS16465	COG0527	aspartate kinase activity
SMAL454_RS16470	COG0626	cystathionine gamma-synthase activity
SMAL454_RS16475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMAL454_RS16480	COG0739	heme binding
SMAL454_RS16485	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMAL454_RS16490	COG1272	protein, Hemolysin III
SMAL454_RS16505	COG0463	Glycosyl transferase, family 2
SMAL454_RS16510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMAL454_RS16515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMAL454_RS16525	COG4206	TonB-dependent receptor
SMAL454_RS16530	COG1309	transcriptional regulator
SMAL454_RS16540	COG1960	acyl-CoA dehydrogenase activity
SMAL454_RS16570	COG0583	DNA-binding transcription factor activity
SMAL454_RS16580	COG0509	glycine decarboxylation via glycine cleavage system
SMAL454_RS16585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMAL454_RS16595	COG0330	HflC and HflK could
SMAL454_RS16605	COG1742	UPF0060 membrane protein
SMAL454_RS16610	COG3956	TIGRFAM MazG family protein
SMAL454_RS16620	COG0494	nUDIX hydrolase
SMAL454_RS16630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMAL454_RS16645	COG0784	Response regulator, receiver
SMAL454_RS16645	COG0643	Histidine kinase
SMAL454_RS16645	COG2198	Histidine kinase
SMAL454_RS16650	COG0840	transmembrane signaling receptor activity
SMAL454_RS16655	COG0835	chemotaxis
SMAL454_RS16670	COG0189	ligase activity
SMAL454_RS16685	COG1199	ATP-dependent helicase activity
SMAL454_RS16700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMAL454_RS16720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMAL454_RS16730	COG1643	Atp-dependent helicase
SMAL454_RS16735	COG0783	Belongs to the Dps family
SMAL454_RS16740	COG0514	ATP-dependent DNA helicase (RecQ)
SMAL454_RS16750	COG2132	Multicopper oxidase
SMAL454_RS16805	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMAL454_RS16810	COG0602	queuosine metabolic process
SMAL454_RS16820	COG2885	chlorophyll binding
SMAL454_RS16825	COG0823	Involved in the tonB-independent uptake of proteins
SMAL454_RS16840	COG0811	peptide transport
SMAL454_RS16845	COG0824	Thioesterase
SMAL454_RS16850	COG2255	four-way junction helicase activity
SMAL454_RS16860	COG0632	four-way junction helicase activity
SMAL454_RS16865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMAL454_RS16870	COG0217	transcriptional regulatory protein
SMAL454_RS16890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMAL454_RS16920	COG0488	(ABC) transporter
SMAL454_RS16930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMAL454_RS16930	COG4651	solute:proton antiporter activity
SMAL454_RS16940	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS16945	COG2205	protein histidine kinase activity
SMAL454_RS16955	COG0542	response to heat
SMAL454_RS16975	COG0028	Belongs to the TPP enzyme family
SMAL454_RS17000	COG3387	PFAM Glycoside hydrolase 15-related
SMAL454_RS17005	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SMAL454_RS17010	COG3011	Protein conserved in bacteria
SMAL454_RS17025	COG0564	pseudouridine synthase activity
SMAL454_RS17030	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMAL454_RS17040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMAL454_RS17040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMAL454_RS17050	COG0045	succinate-CoA ligase (ADP-forming) activity
SMAL454_RS17085	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SMAL454_RS17105	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS17120	COG0189	ligase activity
SMAL454_RS17145	COG4625	pathogenesis
SMAL454_RS17145	COG3240	lipase activity
SMAL454_RS17155	COG2022	thiamine diphosphate biosynthetic process
SMAL454_RS17160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMAL454_RS17165	COG0471	metal ion transport
SMAL454_RS17165	COG3273	potassium ion transport
SMAL454_RS17185	COG1970	mechanosensitive ion channel activity
SMAL454_RS17195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMAL454_RS17200	COG1115	amino acid carrier protein
SMAL454_RS17210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL454_RS17215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL454_RS17240	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMAL454_RS17250	COG3588	fructose-bisphosphate aldolase
SMAL454_RS17255	COG0469	pyruvate kinase activity
SMAL454_RS17265	COG0126	phosphoglycerate kinase activity
SMAL454_RS17280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMAL454_RS17325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMAL454_RS17330	COG1301	dicarboxylic acid transport
SMAL454_RS17360	COG0714	Associated with various cellular activities
SMAL454_RS17390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMAL454_RS17405	COG5295	Hep Hag repeat protein
SMAL454_RS17440	COG0254	rRNA binding
SMAL454_RS17450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMAL454_RS17460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMAL454_RS17465	COG1758	RNA polymerase activity
SMAL454_RS17480	COG0437	4 iron, 4 sulfur cluster binding
SMAL454_RS17485	COG2864	formate dehydrogenase
SMAL454_RS17495	COG1921	L-seryl-tRNASec selenium transferase activity
SMAL454_RS17500	COG3276	selenocysteine insertion sequence binding
SMAL454_RS17510	COG0709	Synthesizes selenophosphate from selenide and ATP
SMAL454_RS17515	COG1561	YicC-like family, N-terminal region
SMAL454_RS17520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SMAL454_RS17525	COG0346	lactoylglutathione lyase activity
SMAL454_RS17535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMAL454_RS17550	COG0006	proline dipeptidase activity
SMAL454_RS17555	COG0006	proline dipeptidase activity
SMAL454_RS17560	COG3079	Belongs to the UPF0149 family
SMAL454_RS17580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMAL454_RS17590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMAL454_RS17600	COG2912	Transglutaminase-like superfamily
SMAL454_RS17605	COG1773	rubredoxin
SMAL454_RS17615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMAL454_RS17620	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
SMAL454_RS17630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMAL454_RS17635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMAL454_RS17645	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS17665	COG0671	phosphoesterase, PA-phosphatase related
SMAL454_RS17675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMAL454_RS17680	COG0563	adenylate kinase activity
SMAL454_RS17700	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SMAL454_RS17710	COG0848	biopolymer transport protein
SMAL454_RS17720	COG2832	Protein of unknown function (DUF454)
SMAL454_RS17755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMAL454_RS17780	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS17790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMAL454_RS17795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMAL454_RS17800	COG0405	Gamma-glutamyltransferase
SMAL454_RS17805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMAL454_RS17825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMAL454_RS17830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMAL454_RS17845	COG0473	3-isopropylmalate dehydrogenase activity
SMAL454_RS17860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL454_RS17865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL454_RS17875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMAL454_RS17880	COG1538	Outer membrane efflux protein
SMAL454_RS17885	COG0531	amino acid
SMAL454_RS17890	COG1519	Transferase
SMAL454_RS17895	COG1560	Kdo2-lipid A biosynthetic process
SMAL454_RS17935	COG1301	dicarboxylic acid transport
SMAL454_RS17945	COG4191	Histidine kinase
SMAL454_RS17965	COG0642	Histidine kinase
SMAL454_RS17980	COG2851	Citrate transporter
SMAL454_RS17985	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS18010	COG1162	GTPase activity
SMAL454_RS18015	COG0436	Aminotransferase
SMAL454_RS18035	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SMAL454_RS18050	COG1228	amidohydrolase
SMAL454_RS18055	COG0804	urea catabolic process
SMAL454_RS18065	COG1307	EDD domain protein, DegV family
SMAL454_RS18110	COG5001	Diguanylate cyclase
SMAL454_RS18110	COG4251	negative regulation of phosphorylation
SMAL454_RS18110	COG3706	GGDEF domain
SMAL454_RS18110	COG2203	Gaf domain
SMAL454_RS18115	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMAL454_RS18125	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SMAL454_RS18140	COG1902	pentaerythritol trinitrate reductase activity
SMAL454_RS18165	COG0583	DNA-binding transcription factor activity
SMAL454_RS18170	COG1064	alcohol dehydrogenase
SMAL454_RS18190	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMAL454_RS18195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMAL454_RS18205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMAL454_RS18210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMAL454_RS18225	COG1522	sequence-specific DNA binding
SMAL454_RS18235	COG4773	Receptor
SMAL454_RS18245	COG4206	TonB-dependent receptor
SMAL454_RS18265	COG0617	tRNA 3'-terminal CCA addition
SMAL454_RS18300	COG3468	outer membrane autotransporter barrel domain protein
SMAL454_RS18310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMAL454_RS18315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMAL454_RS18320	COG1609	Transcriptional regulator
SMAL454_RS18330	COG0837	glucose binding
SMAL454_RS18340	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMAL454_RS18360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMAL454_RS18375	COG4191	Histidine kinase
SMAL454_RS18380	COG0784	Response regulator, receiver
SMAL454_RS18385	COG4251	negative regulation of phosphorylation
SMAL454_RS18390	COG2823	Periplasmic or secreted lipoprotein
SMAL454_RS18395	COG0673	inositol 2-dehydrogenase activity
SMAL454_RS18400	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SMAL454_RS18420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SMAL454_RS18430	COG2921	Belongs to the UPF0250 family
SMAL454_RS18445	COG1686	Belongs to the peptidase S11 family
SMAL454_RS18450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMAL454_RS18455	COG2951	lytic endotransglycosylase activity
SMAL454_RS18460	COG0772	Belongs to the SEDS family
SMAL454_RS18465	COG0772	Belongs to the SEDS family
SMAL454_RS18480	COG1792	Involved in formation and maintenance of cell shape
SMAL454_RS18485	COG1077	Cell shape determining protein MreB Mrl
SMAL454_RS18490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMAL454_RS18505	COG0308	aminopeptidase N
SMAL454_RS18510	COG2226	methyltransferase
SMAL454_RS18540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL454_RS18555	COG0673	inositol 2-dehydrogenase activity
SMAL454_RS18565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMAL454_RS18585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMAL454_RS18595	COG2832	Protein of unknown function (DUF454)
SMAL454_RS18605	COG0436	Aminotransferase
SMAL454_RS18610	COG1505	serine-type exopeptidase activity
SMAL454_RS18635	COG0697	spore germination
SMAL454_RS18640	COG1666	GTP binding
SMAL454_RS18655	COG0339	signal peptide processing
SMAL454_RS18665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMAL454_RS18685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMAL454_RS18695	COG1136	(ABC) transporter
SMAL454_RS18700	COG0577	efflux transmembrane transporter activity
SMAL454_RS18700	COG1136	(ABC) transporter
SMAL454_RS18705	COG0577	efflux transmembrane transporter activity
SMAL454_RS18715	COG2204	response regulator
SMAL454_RS18720	COG4191	Histidine kinase
SMAL454_RS18730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMAL454_RS18740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMAL454_RS18745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMAL454_RS18750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMAL454_RS18755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMAL454_RS18760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMAL454_RS18765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMAL454_RS18775	COG0356	it plays a direct role in the translocation of protons across the membrane
SMAL454_RS18790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMAL454_RS18795	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMAL454_RS18815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMAL454_RS18840	COG0181	hydroxymethylbilane synthase activity
SMAL454_RS18850	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS18850	COG2972	Histidine kinase
SMAL454_RS18865	COG4771	TonB-dependent receptor
SMAL454_RS18900	COG0477	Major facilitator Superfamily
SMAL454_RS18945	COG4206	TonB-dependent receptor
SMAL454_RS18965	COG0625	glutathione transferase activity
SMAL454_RS18980	COG2259	Doxx family
SMAL454_RS19000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMAL454_RS19005	COG1490	D-aminoacyl-tRNA deacylase activity
SMAL454_RS19015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMAL454_RS19055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMAL454_RS19055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMAL454_RS19060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMAL454_RS19065	COG0242	peptide deformylase activity
SMAL454_RS19075	COG0758	DNA mediated transformation
SMAL454_RS19080	COG2922	Belongs to the Smg family
SMAL454_RS19090	COG1714	RDD family
SMAL454_RS19095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMAL454_RS19095	COG1754	DNA topoisomerase type I activity
SMAL454_RS19100	COG0009	L-threonylcarbamoyladenylate synthase
SMAL454_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS19125	COG0616	signal peptide processing
SMAL454_RS19130	COG0534	Mate efflux family protein
SMAL454_RS19145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMAL454_RS19150	COG0625	glutathione transferase activity
SMAL454_RS19160	COG1252	NADH dehydrogenase
SMAL454_RS19180	COG2860	membrane
SMAL454_RS19185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMAL454_RS19205	COG1846	Transcriptional regulator
SMAL454_RS19235	COG0459	protein refolding
SMAL454_RS19240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMAL454_RS19245	COG2356	endonuclease I
SMAL454_RS19250	COG1324	tolerance protein
SMAL454_RS19260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMAL454_RS19290	COG4585	Histidine kinase
SMAL454_RS19310	COG0583	DNA-binding transcription factor activity
SMAL454_RS19325	COG1785	Belongs to the alkaline phosphatase family
SMAL454_RS19330	COG1686	Belongs to the peptidase S11 family
SMAL454_RS19340	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMAL454_RS19350	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMAL454_RS19360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMAL454_RS19365	COG0511	ligase activity, forming carbon-carbon bonds
SMAL454_RS19370	COG0439	Biotin carboxylase
SMAL454_RS19385	COG2264	protein methyltransferase activity
SMAL454_RS19395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
SMAL454_RS19400	COG4589	Belongs to the CDS family
SMAL454_RS19405	COG0204	Acyl-transferase
SMAL454_RS19415	COG0671	phosphoesterase, PA-phosphatase related
SMAL454_RS19415	COG2453	phosphatase
SMAL454_RS19420	COG2267	carboxylic ester hydrolase activity
SMAL454_RS19425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMAL454_RS19430	COG0138	bifunctional purine biosynthesis protein purh
SMAL454_RS19440	COG0151	Belongs to the GarS family
SMAL454_RS19455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMAL454_RS19460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMAL454_RS19465	COG2201	protein-glutamate methylesterase activity
SMAL454_RS19470	COG2177	Part of the ABC transporter FtsEX involved in
SMAL454_RS19475	COG2884	Cell division ATP-binding protein ftsE
SMAL454_RS19485	COG3118	belongs to the thioredoxin family
SMAL454_RS19490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMAL454_RS19495	COG3706	GGDEF domain
SMAL454_RS19505	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
SMAL454_RS19540	COG1652	LysM domain
SMAL454_RS19545	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMAL454_RS19545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMAL454_RS19550	COG1473	amidohydrolase
SMAL454_RS19555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL454_RS19560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL454_RS19565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL454_RS19570	COG1289	transmembrane transporter activity
SMAL454_RS19575	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS19580	COG2814	Major facilitator Superfamily
SMAL454_RS19610	COG0316	Belongs to the HesB IscA family
SMAL454_RS19635	COG0784	Response regulator, receiver
SMAL454_RS19635	COG2205	protein histidine kinase activity
SMAL454_RS19635	COG5002	protein histidine kinase activity
SMAL454_RS19650	COG1051	belongs to the nudix hydrolase family
SMAL454_RS19665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMAL454_RS19670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMAL454_RS19675	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SMAL454_RS19685	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SMAL454_RS19690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMAL454_RS19695	COG0730	response to heat
SMAL454_RS19705	COG0134	indole-3-glycerol-phosphate synthase activity
SMAL454_RS19710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMAL454_RS19730	COG1597	lipid kinase activity
SMAL454_RS19745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMAL454_RS19750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMAL454_RS19760	COG2111	Na H antiporter
SMAL454_RS19760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMAL454_RS19765	COG1006	Multisubunit Na H antiporter MnhC subunit
SMAL454_RS19770	COG0651	ATP synthesis coupled electron transport
SMAL454_RS19775	COG1863	multisubunit Na H antiporter MnhE subunit
SMAL454_RS19780	COG2212	antiporter activity
SMAL454_RS19785	COG1320	monovalent cation:proton antiporter activity
SMAL454_RS19790	COG0530	calcium, potassium:sodium antiporter activity
SMAL454_RS19805	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SMAL454_RS19820	COG4804	nuclease activity
SMAL454_RS19835	COG3104	oligopeptide transport
SMAL454_RS19840	COG3483	tryptophan 2,3-dioxygenase activity
SMAL454_RS19870	COG2378	regulation of single-species biofilm formation
SMAL454_RS19885	COG2354	Protein conserved in bacteria
SMAL454_RS19890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMAL454_RS19895	COG1368	sulfuric ester hydrolase activity
SMAL454_RS19900	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMAL454_RS19900	COG3264	Mechanosensitive ion channel
SMAL454_RS19905	COG2801	Transposase and inactivated derivatives
SMAL454_RS19905	COG3415	Transposase
SMAL454_RS19920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMAL454_RS19955	COG1166	arginine decarboxylase activity
SMAL454_RS19960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMAL454_RS19975	COG3415	Transposase
SMAL454_RS19975	COG2801	Transposase and inactivated derivatives
SMAL454_RS19985	COG2960	long-chain fatty acid transporting porin activity
SMAL454_RS20060	COG0606	chelatase, subunit chli
SMAL454_RS20080	COG0561	phosphatase activity
SMAL454_RS20085	COG3932	Exopolysaccharide synthesis, ExoD
SMAL454_RS20115	COG1999	signal sequence binding
SMAL454_RS20120	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SMAL454_RS20125	COG1845	cytochrome c oxidase, subunit III
SMAL454_RS20135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMAL454_RS20140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMAL454_RS20155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMAL454_RS20160	COG1104	cysteine desulfurase activity
SMAL454_RS20215	COG2031	fatty acid transporter
SMAL454_RS20265	COG0673	inositol 2-dehydrogenase activity
SMAL454_RS20275	COG1501	Belongs to the glycosyl hydrolase 31 family
SMAL454_RS20280	COG2222	sugar isomerase
SMAL454_RS20285	COG1940	carbohydrate kinase activity
SMAL454_RS20295	COG1349	DNA-binding transcription factor activity
SMAL454_RS20300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMAL454_RS20305	COG2814	Major facilitator Superfamily
SMAL454_RS20340	COG1040	competence protein
SMAL454_RS20355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMAL454_RS20360	COG0156	8-amino-7-oxononanoate synthase activity
SMAL454_RS20365	COG2267	carboxylic ester hydrolase activity
SMAL454_RS20385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMAL454_RS20405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL454_RS20410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL454_RS20415	COG2205	protein histidine kinase activity
SMAL454_RS20420	COG0745	RESPONSE REGULATOR receiver
SMAL454_RS20425	COG3541	Predicted nucleotidyltransferase
SMAL454_RS20430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMAL454_RS20455	COG0714	Associated with various cellular activities
SMAL454_RS20470	COG0754	glutathionylspermidine amidase activity
SMAL454_RS20480	COG0129	dihydroxy-acid dehydratase activity
SMAL454_RS20485	COG1199	ATP-dependent helicase activity
SMAL454_RS20495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMAL454_RS20515	COG3781	membrane
SMAL454_RS20545	COG0625	glutathione transferase activity
SMAL454_RS20565	COG2207	Transcriptional regulator
SMAL454_RS20580	COG4555	ABC transporter
SMAL454_RS20610	COG0543	2 iron, 2 sulfur cluster binding
SMAL454_RS20610	COG0633	Ferredoxin
SMAL454_RS20615	COG1131	(ABC) transporter
SMAL454_RS20620	COG0842	Transport permease protein
SMAL454_RS20630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMAL454_RS20640	COG0084	hydrolase, TatD family'
SMAL454_RS20645	COG1643	Atp-dependent helicase
SMAL454_RS20655	COG1187	pseudouridine synthase activity
SMAL454_RS20670	COG0667	Aldo Keto reductase
SMAL454_RS20685	COG1690	Belongs to the RtcB family
SMAL454_RS20700	COG0840	transmembrane signaling receptor activity
SMAL454_RS20705	COG0583	DNA-binding transcription factor activity
SMAL454_RS20710	COG2814	Major facilitator Superfamily
SMAL454_RS20720	COG2267	carboxylic ester hydrolase activity
SMAL454_RS20725	COG0393	Putative heavy-metal-binding
SMAL454_RS20730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMAL454_RS20730	COG1042	CoA-binding domain protein
SMAL454_RS20730	COG0045	succinate-CoA ligase (ADP-forming) activity
SMAL454_RS20735	COG2239	Acts as a magnesium transporter
SMAL454_RS20745	COG3177	Filamentation induced by cAMP protein fic
SMAL454_RS20745	COG0666	response to abiotic stimulus
SMAL454_RS20750	COG3100	YcgL domain-containing protein
SMAL454_RS20760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMAL454_RS20765	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL454_RS20805	COG2986	histidine ammonia-lyase
SMAL454_RS20815	COG0463	Glycosyl transferase, family 2
SMAL454_RS20830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMAL454_RS20835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMAL454_RS20850	COG1294	oxidase, subunit
SMAL454_RS20855	COG1271	oxidase subunit
SMAL454_RS20865	COG3209	COG3209 Rhs family protein
SMAL454_RS20880	COG1595	DNA-templated transcription, initiation
SMAL454_RS20920	COG0408	coproporphyrinogen oxidase activity
SMAL454_RS20930	COG2323	membrane
SMAL454_RS20945	COG0589	response to stress
SMAL454_RS20970	COG0210	DNA helicase
SMAL454_RS20980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMAL454_RS20985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMAL454_RS20990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMAL454_RS20995	COG1819	glycosyl
SMAL454_RS21010	COG0251	oxidation-reduction process
SMAL454_RS21045	COG0463	Glycosyl transferase, family 2
SMAL454_RS21060	COG1475	DNA binding
SMAL454_RS21065	COG1192	Involved in chromosome partitioning
SMAL454_RS21070	COG0357	Ribosomal RNA small subunit methyltransferase G
SMAL454_RS21075	COG2091	lysine biosynthetic process via aminoadipic acid
SMAL454_RS21115	COG1971	Probably functions as a manganese efflux pump
SMAL454_RS21120	COG2205	protein histidine kinase activity
SMAL454_RS21120	COG0784	Response regulator, receiver
SMAL454_RS21130	COG0443	Heat shock 70 kDa protein
SMAL454_RS21140	COG2911	Protein conserved in bacteria
SMAL454_RS21145	COG0729	surface antigen
SMAL454_RS21155	COG0752	glycyl-tRNA synthetase alpha subunit
SMAL454_RS21160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMAL454_RS21165	COG0519	Catalyzes the synthesis of GMP from XMP
SMAL454_RS21165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMAL454_RS21175	COG0805	protein transport
SMAL454_RS21185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMAL454_RS21195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMAL454_RS21200	COG0596	Alpha beta hydrolase
SMAL454_RS21200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMAL454_RS21205	COG0840	transmembrane signaling receptor activity
SMAL454_RS21235	COG3135	benzoate transporter
SMAL454_RS21250	COG2951	lytic endotransglycosylase activity
SMAL454_RS21255	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SMAL454_RS21260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMAL454_RS21265	COG3706	GGDEF domain
SMAL454_RS21295	COG0302	gtp cyclohydrolase
SMAL454_RS21320	COG1289	transmembrane transporter activity
SMAL454_RS21335	COG1074	ATP-dependent DNA helicase activity
SMAL454_RS21340	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SMAL454_RS21345	COG1127	ABC transporter
SMAL454_RS21350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMAL454_RS21355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMAL454_RS21370	COG2853	Lipoprotein
SMAL454_RS21375	COG0386	Belongs to the glutathione peroxidase family
SMAL454_RS21385	COG1322	Protein conserved in bacteria
SMAL454_RS21395	COG0604	alcohol dehydrogenase
SMAL454_RS21400	COG0583	DNA-binding transcription factor activity
SMAL454_RS21420	COG0531	amino acid
SMAL454_RS21430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMAL454_RS21435	COG0861	Integral membrane protein TerC family
SMAL454_RS21445	COG0584	glycerophosphoryl diester phosphodiesterase
SMAL454_RS21460	COG0706	membrane insertase activity
SMAL454_RS21465	COG0594	ribonuclease P activity
SMAL454_RS21470	COG0230	Belongs to the bacterial ribosomal protein bL34 family