locus-tag	class	description
BTU49_RS00025	COG2133	pyrroloquinoline quinone binding
BTU49_RS00030	COG4682	membrane
BTU49_RS00040	COG0531	amino acid
BTU49_RS00050	COG1737	Transcriptional regulator
BTU49_RS00055	COG4948	Mandelate Racemase Muconate Lactonizing
BTU49_RS00085	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BTU49_RS00110	COG5383	Protein conserved in bacteria
BTU49_RS00120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BTU49_RS00130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BTU49_RS00140	COG0778	Nitroreductase
BTU49_RS00145	COG2353	YceI-like domain
BTU49_RS00160	COG2375	cellular response to nickel ion
BTU49_RS00180	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BTU49_RS00275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTU49_RS00280	COG1012	belongs to the aldehyde dehydrogenase family
BTU49_RS00325	COG2267	carboxylic ester hydrolase activity
BTU49_RS00350	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
BTU49_RS00400	COG0488	(ABC) transporter
BTU49_RS00405	COG0583	DNA-binding transcription factor activity
BTU49_RS00415	COG2814	Major facilitator Superfamily
BTU49_RS00420	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BTU49_RS00425	COG1113	amino acid transport
BTU49_RS00430	COG0741	lytic transglycosylase activity
BTU49_RS00455	COG2764	glyoxalase bleomycin resistance protein dioxygenase
BTU49_RS00465	COG5507	3-demethylubiquinone-9 3-methyltransferase
BTU49_RS00470	COG4941	Belongs to the sigma-70 factor family
BTU49_RS00480	COG3275	phosphorelay sensor kinase activity
BTU49_RS00485	COG3279	Response regulator of the LytR AlgR family
BTU49_RS00500	COG1309	transcriptional regulator
BTU49_RS00510	COG2814	Major facilitator Superfamily
BTU49_RS00515	COG3590	peptidase
BTU49_RS00520	COG5001	Diguanylate cyclase
BTU49_RS00525	COG0583	DNA-binding transcription factor activity
BTU49_RS00535	COG3384	dioxygenase
BTU49_RS00545	COG0025	NhaP-type Na H and K H
BTU49_RS00600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTU49_RS00615	COG0784	Response regulator, receiver
BTU49_RS00615	COG2205	protein histidine kinase activity
BTU49_RS00630	COG2813	Specifically methylates the guanine in position
BTU49_RS00635	COG1187	pseudouridine synthase activity
BTU49_RS00640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTU49_RS00650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BTU49_RS00655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BTU49_RS00670	COG0583	DNA-binding transcription factor activity
BTU49_RS00675	COG2226	methyltransferase
BTU49_RS00680	COG0546	phosphoglycolate phosphatase activity
BTU49_RS00700	COG1956	GAF domain-containing protein
BTU49_RS00705	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BTU49_RS00710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTU49_RS00715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTU49_RS00720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTU49_RS00720	COG0785	Cytochrome C biogenesis protein
BTU49_RS00730	COG0745	RESPONSE REGULATOR receiver
BTU49_RS00735	COG5002	protein histidine kinase activity
BTU49_RS00745	COG0720	synthase
BTU49_RS00770	COG0513	Belongs to the DEAD box helicase family
BTU49_RS00780	COG0625	glutathione transferase activity
BTU49_RS00785	COG1573	uracil-dna glycosylase
BTU49_RS00820	COG0626	cystathionine gamma-synthase activity
BTU49_RS00850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BTU49_RS00850	COG2755	lipolytic protein G-D-S-L family
BTU49_RS00895	COG0300	oxidoreductase activity
BTU49_RS00900	COG0277	FAD linked oxidase domain protein
BTU49_RS00905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BTU49_RS00905	COG0546	phosphoglycolate phosphatase activity
BTU49_RS00955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTU49_RS00975	COG1216	Glycosyl transferase, family 2
BTU49_RS00990	COG1127	ABC transporter
BTU49_RS00995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTU49_RS01010	COG0442	prolyl-tRNA aminoacylation
BTU49_RS01020	COG1183	phosphatidylcholine synthase activity
BTU49_RS01040	COG0525	valine-tRNA ligase activity
BTU49_RS01050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BTU49_RS01060	COG0795	lipopolysaccharide-transporting ATPase activity
BTU49_RS01075	COG4974	Belongs to the 'phage' integrase family
BTU49_RS01080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTU49_RS01095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTU49_RS01095	COG0047	phosphoribosylformylglycinamidine synthase activity
BTU49_RS01105	COG1404	Belongs to the peptidase S8 family
BTU49_RS01110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BTU49_RS01115	COG1459	type II secretion system
BTU49_RS01120	COG2165	general secretion pathway protein
BTU49_RS01125	COG4970	Tfp pilus assembly protein FimT
BTU49_RS01130	COG2165	general secretion pathway protein
BTU49_RS01135	COG4795	General secretion pathway protein
BTU49_RS01140	COG3156	type II secretion system protein K
BTU49_RS01145	COG3166	PFAM Fimbrial assembly family protein
BTU49_RS01160	COG1450	Type ii and iii secretion system protein
BTU49_RS01190	COG3539	Fimbrial protein
BTU49_RS01195	COG3121	Chaperone
BTU49_RS01210	COG2252	PERMEase
BTU49_RS01215	COG0488	(ABC) transporter
BTU49_RS01225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BTU49_RS01235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BTU49_RS01240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTU49_RS01240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTU49_RS01280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BTU49_RS01285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTU49_RS01300	COG0277	FAD linked oxidase domain protein
BTU49_RS01305	COG1988	membrane-bound metal-dependent
BTU49_RS01335	COG2001	Belongs to the MraZ family
BTU49_RS01340	COG0275	rRNA processing
BTU49_RS01345	COG3116	cell division
BTU49_RS01360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BTU49_RS01380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTU49_RS01385	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTU49_RS01390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BTU49_RS01400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BTU49_RS01405	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BTU49_RS01415	COG0739	heme binding
BTU49_RS01420	COG0653	protein targeting
BTU49_RS01425	COG0494	nUDIX hydrolase
BTU49_RS01435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BTU49_RS01440	COG2267	carboxylic ester hydrolase activity
BTU49_RS01445	COG3275	phosphorelay sensor kinase activity
BTU49_RS01450	COG3279	Response regulator of the LytR AlgR family
BTU49_RS01470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTU49_RS01475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BTU49_RS01485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BTU49_RS01495	COG1607	acyl-coa hydrolase
BTU49_RS01505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BTU49_RS01525	COG4106	trans-aconitate 2-methyltransferase activity
BTU49_RS01530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTU49_RS01540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BTU49_RS01545	COG0667	Aldo Keto reductase
BTU49_RS01555	COG4771	TonB-dependent receptor
BTU49_RS01575	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BTU49_RS01580	COG4181	ATPase activity
BTU49_RS01595	COG0642	Histidine kinase
BTU49_RS01605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BTU49_RS01610	COG0861	Integral membrane protein TerC family
BTU49_RS01615	COG2814	Major facilitator Superfamily
BTU49_RS01620	COG1704	LemA family
BTU49_RS01635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BTU49_RS01640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BTU49_RS01660	COG3738	Protein conserved in bacteria
BTU49_RS01665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTU49_RS01670	COG2967	ApaG domain
BTU49_RS01680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BTU49_RS01690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BTU49_RS01700	COG2096	Adenosyltransferase
BTU49_RS01710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTU49_RS01715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTU49_RS01720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BTU49_RS01725	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BTU49_RS01745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTU49_RS01755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTU49_RS01765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTU49_RS01770	COG0583	DNA-binding transcription factor activity
BTU49_RS01775	COG3634	alkyl hydroperoxide reductase activity
BTU49_RS01820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTU49_RS01820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTU49_RS01825	COG0778	Nitroreductase
BTU49_RS01835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BTU49_RS01860	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BTU49_RS01875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTU49_RS01880	COG1404	Belongs to the peptidase S8 family
BTU49_RS01900	COG1295	ribonuclease BN
BTU49_RS01905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTU49_RS01925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BTU49_RS01930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BTU49_RS01945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BTU49_RS01955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BTU49_RS01960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BTU49_RS01965	COG0193	aminoacyl-tRNA hydrolase activity
BTU49_RS01970	COG0012	GTP binding
BTU49_RS01980	COG4242	Belongs to the peptidase S51 family
BTU49_RS01985	COG1446	asparaginase
BTU49_RS02005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTU49_RS02020	COG0250	Participates in transcription elongation, termination and antitermination
BTU49_RS02025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BTU49_RS02030	COG0081	regulation of translation
BTU49_RS02035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BTU49_RS02040	COG0222	ribosome binding
BTU49_RS02045	COG0085	RNA polymerase activity
BTU49_RS02050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BTU49_RS02055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BTU49_RS02060	COG0049	tRNA binding
BTU49_RS02065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTU49_RS02070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTU49_RS02075	COG0051	transcription antitermination factor activity, RNA binding
BTU49_RS02080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BTU49_RS02085	COG0088	Forms part of the polypeptide exit tunnel
BTU49_RS02090	COG0089	rRNA binding
BTU49_RS02095	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BTU49_RS02100	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BTU49_RS02105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BTU49_RS02110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BTU49_RS02115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BTU49_RS02120	COG0255	Belongs to the universal ribosomal protein uL29 family
BTU49_RS02125	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BTU49_RS02130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BTU49_RS02135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BTU49_RS02140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BTU49_RS02145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BTU49_RS02150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BTU49_RS02155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BTU49_RS02160	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BTU49_RS02165	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BTU49_RS02170	COG1841	ribosomal large subunit assembly
BTU49_RS02175	COG0200	Binds to the 23S rRNA
BTU49_RS02180	COG0201	protein transport
BTU49_RS02185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BTU49_RS02190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BTU49_RS02195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BTU49_RS02200	COG0202	RNA polymerase activity
BTU49_RS02205	COG0203	ribosomal protein L17
BTU49_RS02220	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BTU49_RS02230	COG0154	amidase activity
BTU49_RS02245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BTU49_RS02250	COG0039	L-malate dehydrogenase activity
BTU49_RS02255	COG0564	pseudouridine synthase activity
BTU49_RS02260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTU49_RS02275	COG0625	glutathione transferase activity
BTU49_RS02285	COG1902	pentaerythritol trinitrate reductase activity
BTU49_RS02285	COG0446	pyridine nucleotide-disulphide oxidoreductase
BTU49_RS02300	COG1187	pseudouridine synthase activity
BTU49_RS02320	COG1063	alcohol dehydrogenase
BTU49_RS02330	COG0588	phosphoglycerate mutase activity
BTU49_RS02335	COG0285	dihydrofolate synthase activity
BTU49_RS02355	COG2833	Protein of unknown function (DUF455)
BTU49_RS02365	COG3291	Pkd domain containing protein
BTU49_RS02370	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTU49_RS02375	COG0671	phosphoesterase, PA-phosphatase related
BTU49_RS02380	COG0438	transferase activity, transferring glycosyl groups
BTU49_RS02395	COG0248	Ppx GppA phosphatase
BTU49_RS02400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BTU49_RS02415	COG4783	chaperone-mediated protein folding
BTU49_RS02430	COG0473	3-isopropylmalate dehydrogenase activity
BTU49_RS02450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTU49_RS02510	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTU49_RS02520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BTU49_RS02585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTU49_RS02590	COG3942	CHAP domain
BTU49_RS02590	COG1388	LysM domain
BTU49_RS02595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTU49_RS02610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTU49_RS02615	COG0631	protein serine/threonine phosphatase activity
BTU49_RS02630	COG0859	PFAM glycosyl transferase family 9
BTU49_RS02635	COG3642	lipopolysaccharide core region biosynthetic process
BTU49_RS02640	COG1234	tRNA 3'-trailer cleavage
BTU49_RS02680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BTU49_RS02685	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BTU49_RS02695	COG0537	adenosine 5'-monophosphoramidase activity
BTU49_RS02715	COG0714	Associated with various cellular activities
BTU49_RS02730	COG1399	metal-binding, possibly nucleic acid-binding protein
BTU49_RS02735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BTU49_RS02740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTU49_RS02750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BTU49_RS02765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BTU49_RS02770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BTU49_RS02775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BTU49_RS02780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BTU49_RS02820	COG4774	siderophore transport
BTU49_RS02840	COG0714	Associated with various cellular activities
BTU49_RS02850	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BTU49_RS02860	COG2226	methyltransferase
BTU49_RS02865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTU49_RS02870	COG0697	spore germination
BTU49_RS02890	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS02895	COG0583	DNA-binding transcription factor activity
BTU49_RS02935	COG0583	DNA-binding transcription factor activity
BTU49_RS02965	COG0667	Aldo Keto reductase
BTU49_RS02985	COG0519	Catalyzes the synthesis of GMP from XMP
BTU49_RS02990	COG1678	Uncharacterized ACR, COG1678
BTU49_RS02995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BTU49_RS03000	COG0540	Belongs to the ATCase OTCase family
BTU49_RS03020	COG2239	Acts as a magnesium transporter
BTU49_RS03025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BTU49_RS03040	COG1660	Displays ATPase and GTPase activities
BTU49_RS03045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BTU49_RS03050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTU49_RS03055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BTU49_RS03065	COG1137	ATPase activity
BTU49_RS03080	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BTU49_RS03095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTU49_RS03115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BTU49_RS03130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BTU49_RS03140	COG0628	permease
BTU49_RS03150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BTU49_RS03160	COG2261	transglycosylase associated protein
BTU49_RS03190	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BTU49_RS03195	COG1477	protein flavinylation
BTU49_RS03215	COG4771	TonB-dependent receptor
BTU49_RS03225	COG3128	pkhd-type hydroxylase
BTU49_RS03240	COG2146	nitrite reductase [NAD(P)H] activity
BTU49_RS03260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BTU49_RS03265	COG0719	Fe-S assembly protein
BTU49_RS03270	COG0396	ATPase activity
BTU49_RS03275	COG0719	Fe-S assembly protein
BTU49_RS03280	COG1959	2 iron, 2 sulfur cluster binding
BTU49_RS03290	COG0693	protein deglycase activity
BTU49_RS03315	COG1764	response to oxidative stress
BTU49_RS03320	COG0384	phenazine biosynthesis protein PhzF
BTU49_RS03330	COG0527	aspartate kinase activity
BTU49_RS03340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BTU49_RS03360	COG0142	geranyltranstransferase activity
BTU49_RS03365	COG0366	Alpha amylase catalytic
BTU49_RS03390	COG1082	Xylose isomerase domain protein TIM barrel
BTU49_RS03400	COG2190	(PTS) system
BTU49_RS03400	COG2211	Major facilitator Superfamily
BTU49_RS03440	COG1131	(ABC) transporter
BTU49_RS03450	COG0629	single-stranded DNA binding
BTU49_RS03455	COG0300	oxidoreductase activity
BTU49_RS03485	COG2010	Cytochrome c
BTU49_RS03495	COG0673	inositol 2-dehydrogenase activity
BTU49_RS03500	COG2211	Major facilitator Superfamily
BTU49_RS03510	COG1609	Transcriptional regulator
BTU49_RS03535	COG0640	Transcriptional regulator
BTU49_RS03545	COG3655	Transcriptional regulator
BTU49_RS03550	COG1253	flavin adenine dinucleotide binding
BTU49_RS03555	COG1408	metallophosphoesterase
BTU49_RS03565	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BTU49_RS03585	COG2259	Doxx family
BTU49_RS03610	COG0477	Major facilitator Superfamily
BTU49_RS03630	COG1802	Transcriptional regulator
BTU49_RS03665	COG3052	prosthetic group binding
BTU49_RS03675	COG4773	Receptor
BTU49_RS03680	COG0579	oxidoreductase
BTU49_RS03700	COG0456	acetyltransferase
BTU49_RS03730	COG3104	oligopeptide transport
BTU49_RS03740	COG1297	OPT oligopeptide transporter protein
BTU49_RS03745	COG0823	Involved in the tonB-independent uptake of proteins
BTU49_RS03745	COG1506	peptidase
BTU49_RS03760	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BTU49_RS03765	COG2894	cell division
BTU49_RS03780	COG4585	Histidine kinase
BTU49_RS03785	COG2197	response regulator
BTU49_RS03810	COG1073	alpha beta
BTU49_RS03830	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BTU49_RS03840	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BTU49_RS03850	COG1595	DNA-templated transcription, initiation
BTU49_RS03860	COG1946	Acyl-CoA thioesterase
BTU49_RS03885	COG0824	Thioesterase
BTU49_RS03890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BTU49_RS03895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BTU49_RS03900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BTU49_RS03905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BTU49_RS03910	COG0268	Binds directly to 16S ribosomal RNA
BTU49_RS03915	COG0728	peptidoglycan biosynthetic process
BTU49_RS03920	COG0196	riboflavin kinase activity
BTU49_RS03925	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BTU49_RS03935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BTU49_RS03955	COG4206	TonB-dependent receptor
BTU49_RS03975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTU49_RS03985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BTU49_RS04045	COG0431	NADPH-dependent FMN reductase
BTU49_RS04055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTU49_RS04060	COG0798	PFAM Bile acid sodium symporter
BTU49_RS04095	COG4974	Belongs to the 'phage' integrase family
BTU49_RS04100	COG3209	COG3209 Rhs family protein
BTU49_RS04130	COG4245	von Willebrand factor, type A
BTU49_RS04170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTU49_RS04175	COG1845	cytochrome c oxidase, subunit III
BTU49_RS04180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTU49_RS04195	COG0326	Molecular chaperone. Has ATPase activity
BTU49_RS04215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BTU49_RS04225	COG2070	2-Nitropropane dioxygenase
BTU49_RS04235	COG0228	four-way junction DNA binding
BTU49_RS04240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BTU49_RS04245	COG0336	Belongs to the RNA methyltransferase TrmD family
BTU49_RS04250	COG0335	large ribosomal subunit rRNA binding
BTU49_RS04270	COG0534	Mate efflux family protein
BTU49_RS04290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BTU49_RS04300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BTU49_RS04305	COG1522	sequence-specific DNA binding
BTU49_RS04310	COG4771	TonB-dependent receptor
BTU49_RS04315	COG0531	amino acid
BTU49_RS04335	COG1506	peptidase
BTU49_RS04335	COG0823	Involved in the tonB-independent uptake of proteins
BTU49_RS04335	COG4946	Tricorn protease homolog
BTU49_RS04345	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BTU49_RS04380	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS04385	COG4948	Mandelate Racemase Muconate Lactonizing
BTU49_RS04390	COG0800	Aldolase
BTU49_RS04395	COG1802	Transcriptional regulator
BTU49_RS04415	COG3734	2-keto-3-deoxy-galactonokinase
BTU49_RS04420	COG3940	Belongs to the glycosyl hydrolase 43 family
BTU49_RS04430	COG0583	DNA-binding transcription factor activity
BTU49_RS04455	COG3134	Outer membrane lipoprotein
BTU49_RS04475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTU49_RS04505	COG0024	Methionine aminopeptidase
BTU49_RS04555	COG2814	Major facilitator Superfamily
BTU49_RS04560	COG3706	GGDEF domain
BTU49_RS04575	COG0588	phosphoglycerate mutase activity
BTU49_RS04585	COG3590	peptidase
BTU49_RS04600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BTU49_RS04610	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BTU49_RS04615	COG0745	RESPONSE REGULATOR receiver
BTU49_RS04620	COG2205	protein histidine kinase activity
BTU49_RS04625	COG4452	Inner membrane protein CreD
BTU49_RS04640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTU49_RS04645	COG0735	belongs to the Fur family
BTU49_RS04730	COG5002	protein histidine kinase activity
BTU49_RS04730	COG5001	Diguanylate cyclase
BTU49_RS04740	COG1187	pseudouridine synthase activity
BTU49_RS04775	COG1132	(ABC) transporter
BTU49_RS04820	COG1695	Transcriptional regulator
BTU49_RS04840	COG1981	membrane
BTU49_RS04845	COG0825	malonyl-CoA metabolic process
BTU49_RS04860	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTU49_RS04865	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTU49_RS04870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BTU49_RS04875	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTU49_RS04880	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTU49_RS04885	COG0750	zinc metalloprotease
BTU49_RS04890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BTU49_RS04895	COG0575	Belongs to the CDS family
BTU49_RS04900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BTU49_RS04905	COG0233	cytoplasmic translational termination
BTU49_RS04910	COG0528	UMP kinase activity
BTU49_RS04920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BTU49_RS04925	COG0052	Belongs to the universal ribosomal protein uS2 family
BTU49_RS04935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BTU49_RS04950	COG1393	Belongs to the ArsC family
BTU49_RS04955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTU49_RS04960	COG0367	asparagine synthase
BTU49_RS04965	COG0475	glutathione-regulated potassium exporter activity
BTU49_RS05000	COG1566	PFAM secretion protein HlyD family protein
BTU49_RS05005	COG2814	Major facilitator Superfamily
BTU49_RS05015	COG0583	DNA-binding transcription factor activity
BTU49_RS05035	COG0557	exoribonuclease II activity
BTU49_RS05045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTU49_RS05050	COG1538	Outer membrane efflux protein
BTU49_RS05055	COG0577	efflux transmembrane transporter activity
BTU49_RS05055	COG1136	(ABC) transporter
BTU49_RS05060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTU49_RS05070	COG2205	protein histidine kinase activity
BTU49_RS05080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTU49_RS05090	COG2259	Doxx family
BTU49_RS05100	COG3220	belongs to the UPF0276 family
BTU49_RS05110	COG0704	Plays a role in the regulation of phosphate uptake
BTU49_RS05120	COG0581	inorganic phosphate transmembrane transporter activity
BTU49_RS05125	COG0573	inorganic phosphate transmembrane transporter activity
BTU49_RS05130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BTU49_RS05135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BTU49_RS05145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BTU49_RS05155	COG1024	Enoyl-CoA hydratase
BTU49_RS05165	COG0494	nUDIX hydrolase
BTU49_RS05185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BTU49_RS05185	COG0116	Belongs to the methyltransferase superfamily
BTU49_RS05220	COG2733	membrane
BTU49_RS05230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTU49_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
BTU49_RS05245	COG0477	Major facilitator Superfamily
BTU49_RS05250	COG2703	oxygen carrier activity
BTU49_RS05270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTU49_RS05280	COG0174	glutamine synthetase
BTU49_RS05305	COG3842	ATPase activity
BTU49_RS05310	COG1176	ABC-type spermidine putrescine transport system, permease component I
BTU49_RS05315	COG1177	transmembrane transport
BTU49_RS05320	COG1012	belongs to the aldehyde dehydrogenase family
BTU49_RS05335	COG4535	Mg2 and Co2 transporter CorC
BTU49_RS05350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BTU49_RS05355	COG1702	phosphate starvation-inducible protein PhoH
BTU49_RS05365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTU49_RS05395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTU49_RS05410	COG0741	lytic transglycosylase activity
BTU49_RS05415	COG0723	plastoquinol--plastocyanin reductase activity
BTU49_RS05420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BTU49_RS05425	COG2857	Cytochrome c1
BTU49_RS05430	COG0625	glutathione transferase activity
BTU49_RS05435	COG2969	positive regulation of protein catabolic process
BTU49_RS05470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTU49_RS05475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BTU49_RS05490	COG1611	Belongs to the LOG family
BTU49_RS05495	COG4969	Belongs to the N-Me-Phe pilin family
BTU49_RS05535	COG0556	nucleotide-excision repair
BTU49_RS05565	COG3713	MltA-interacting MipA family protein
BTU49_RS05575	COG2205	protein histidine kinase activity
BTU49_RS05580	COG0658	competence protein
BTU49_RS05580	COG2333	competence protein COMEC
BTU49_RS05585	COG0811	peptide transport
BTU49_RS05590	COG0848	biopolymer transport protein
BTU49_RS05600	COG1663	tetraacyldisaccharide 4'-kinase activity
BTU49_RS05605	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BTU49_RS05610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTU49_RS05620	COG0322	excinuclease ABC activity
BTU49_RS05625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BTU49_RS05685	COG1397	ADP-ribosylglycohydrolase
BTU49_RS05710	COG0583	DNA-binding transcription factor activity
BTU49_RS05730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTU49_RS05750	COG0348	domain, Protein
BTU49_RS05765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTU49_RS05790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BTU49_RS05795	COG0069	glutamate synthase activity
BTU49_RS05825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTU49_RS05840	COG1253	flavin adenine dinucleotide binding
BTU49_RS05850	COG0306	phosphate transporter
BTU49_RS05860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BTU49_RS05875	COG0504	CTP synthase activity
BTU49_RS05880	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BTU49_RS05895	COG0148	phosphopyruvate hydratase activity
BTU49_RS05900	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BTU49_RS05905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BTU49_RS05910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BTU49_RS05920	COG2840	Smr protein MutS2
BTU49_RS05925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BTU49_RS05930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BTU49_RS05950	COG1534	Rna-binding protein
BTU49_RS05955	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BTU49_RS05960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTU49_RS05975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BTU49_RS05980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BTU49_RS05985	COG1923	regulation of RNA biosynthetic process
BTU49_RS05990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BTU49_RS05995	COG0477	Major facilitator Superfamily
BTU49_RS06000	COG1546	Belongs to the CinA family
BTU49_RS06005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BTU49_RS06010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BTU49_RS06015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BTU49_RS06020	COG2137	regulation of response to DNA damage stimulus
BTU49_RS06025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BTU49_RS06030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BTU49_RS06045	COG4206	TonB-dependent receptor
BTU49_RS06065	COG1201	RNA secondary structure unwinding
BTU49_RS06085	COG3258	Cytochrome c
BTU49_RS06100	COG2223	nitrite transmembrane transporter activity
BTU49_RS06105	COG1741	Belongs to the pirin family
BTU49_RS06110	COG0583	DNA-binding transcription factor activity
BTU49_RS06140	COG0352	thiamine-phosphate diphosphorylase activity
BTU49_RS06140	COG0351	phosphomethylpyrimidine kinase
BTU49_RS06155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BTU49_RS06160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BTU49_RS06170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTU49_RS06180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BTU49_RS06185	COG1070	Carbohydrate kinase
BTU49_RS06195	COG0477	Major facilitator Superfamily
BTU49_RS06205	COG0617	tRNA 3'-terminal CCA addition
BTU49_RS06210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BTU49_RS06215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BTU49_RS06220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BTU49_RS06225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BTU49_RS06230	COG0166	Belongs to the GPI family
BTU49_RS06235	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BTU49_RS06245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BTU49_RS06250	COG0671	phosphoesterase, PA-phosphatase related
BTU49_RS06260	COG0800	Aldolase
BTU49_RS06265	COG0129	dihydroxy-acid dehydratase activity
BTU49_RS06275	COG0837	glucose binding
BTU49_RS06280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BTU49_RS06285	COG3842	ATPase activity
BTU49_RS06290	COG0354	folic acid binding
BTU49_RS06300	COG2009	succinate dehydrogenase
BTU49_RS06305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BTU49_RS06310	COG1053	succinate dehydrogenase
BTU49_RS06315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BTU49_RS06330	COG4591	ABC-type transport system involved in lipoprotein release permease component
BTU49_RS06345	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BTU49_RS06355	COG0552	protein localization to endoplasmic reticulum
BTU49_RS06370	COG0742	ribosomal rna small subunit methyltransferase
BTU49_RS06375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BTU49_RS06385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BTU49_RS06390	COG0405	Gamma-glutamyltransferase
BTU49_RS06395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTU49_RS06410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BTU49_RS06430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BTU49_RS06445	COG0415	Belongs to the DNA photolyase family
BTU49_RS06455	COG4221	oxidoreductase activity
BTU49_RS06465	COG0583	DNA-binding transcription factor activity
BTU49_RS06570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BTU49_RS06585	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTU49_RS06590	COG0735	belongs to the Fur family
BTU49_RS06600	COG0583	DNA-binding transcription factor activity
BTU49_RS06605	COG0497	DNA recombination
BTU49_RS06610	COG1420	regulation of RNA biosynthetic process
BTU49_RS06615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BTU49_RS06620	COG0443	Heat shock 70 kDa protein
BTU49_RS06625	COG0484	heat shock protein binding
BTU49_RS06630	COG2207	Transcriptional regulator
BTU49_RS06635	COG2223	nitrite transmembrane transporter activity
BTU49_RS06640	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BTU49_RS06645	COG1605	Chorismate mutase
BTU49_RS06645	COG0287	Prephenate dehydrogenase
BTU49_RS06655	COG1132	(ABC) transporter
BTU49_RS06675	COG5001	Diguanylate cyclase
BTU49_RS06685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTU49_RS06690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BTU49_RS06695	COG0343	queuine tRNA-ribosyltransferase activity
BTU49_RS06700	COG1862	Preprotein translocase
BTU49_RS06705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTU49_RS06710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTU49_RS06715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BTU49_RS06725	COG2081	HI0933 family
BTU49_RS06730	COG4681	YaeQ
BTU49_RS06760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BTU49_RS06765	COG3420	alginic acid biosynthetic process
BTU49_RS06775	COG0710	3-dehydroquinate dehydratase activity
BTU49_RS06790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BTU49_RS06800	COG3485	protocatechuate 3,4-dioxygenase
BTU49_RS06805	COG3485	protocatechuate 3,4-dioxygenase
BTU49_RS06815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTU49_RS06820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTU49_RS06825	COG1414	Transcriptional regulator
BTU49_RS06835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTU49_RS06840	COG0513	Belongs to the DEAD box helicase family
BTU49_RS06855	COG0583	DNA-binding transcription factor activity
BTU49_RS06860	COG0488	(ABC) transporter
BTU49_RS06885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTU49_RS06900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTU49_RS06905	COG2957	Belongs to the agmatine deiminase family
BTU49_RS06915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTU49_RS06920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BTU49_RS06930	COG0776	regulation of translation
BTU49_RS06940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BTU49_RS06955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BTU49_RS06960	COG0183	Belongs to the thiolase family
BTU49_RS06965	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTU49_RS06965	COG1024	Enoyl-CoA hydratase
BTU49_RS06975	COG0105	UTP biosynthetic process
BTU49_RS06980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTU49_RS06990	COG1426	Protein conserved in bacteria
BTU49_RS07000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTU49_RS07005	COG1160	GTP binding
BTU49_RS07010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTU49_RS07015	COG0475	glutathione-regulated potassium exporter activity
BTU49_RS07015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BTU49_RS07020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BTU49_RS07030	COG0519	Catalyzes the synthesis of GMP from XMP
BTU49_RS07030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTU49_RS07035	COG5290	Psort location Cytoplasmic, score
BTU49_RS07040	COG0583	DNA-binding transcription factor activity
BTU49_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS07075	COG2207	Transcriptional regulator
BTU49_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS07105	COG3300	MHYT domain
BTU49_RS07105	COG5001	Diguanylate cyclase
BTU49_RS07110	COG3706	GGDEF domain
BTU49_RS07120	COG0300	oxidoreductase activity
BTU49_RS07125	COG2207	Transcriptional regulator
BTU49_RS07150	COG2204	response regulator
BTU49_RS07175	COG0431	NADPH-dependent FMN reductase
BTU49_RS07185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTU49_RS07190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTU49_RS07195	COG1473	amidohydrolase
BTU49_RS07205	COG1126	abc transporter atp-binding protein
BTU49_RS07210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTU49_RS07240	COG0697	spore germination
BTU49_RS07245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BTU49_RS07250	COG0167	dihydroorotate dehydrogenase activity
BTU49_RS07265	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS07270	COG1012	belongs to the aldehyde dehydrogenase family
BTU49_RS07285	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTU49_RS07350	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTU49_RS07370	COG0745	RESPONSE REGULATOR receiver
BTU49_RS07375	COG0784	Response regulator, receiver
BTU49_RS07375	COG4191	Histidine kinase
BTU49_RS07380	COG3850	Histidine kinase
BTU49_RS07380	COG3437	response regulator, receiver
BTU49_RS07380	COG2205	protein histidine kinase activity
BTU49_RS07380	COG4999	Histidine kinase
BTU49_RS07385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BTU49_RS07395	COG2205	protein histidine kinase activity
BTU49_RS07430	COG0083	homoserine kinase activity
BTU49_RS07435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BTU49_RS07440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTU49_RS07445	COG0124	histidyl-tRNA synthetase
BTU49_RS07460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BTU49_RS07465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BTU49_RS07470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTU49_RS07475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BTU49_RS07475	COG0131	Imidazoleglycerol-phosphate dehydratase
BTU49_RS07480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BTU49_RS07485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BTU49_RS07490	COG0107	imidazoleglycerol-phosphate synthase activity
BTU49_RS07505	COG0837	glucose binding
BTU49_RS07510	COG1446	asparaginase
BTU49_RS07515	COG3142	Participates in the control of copper homeostasis
BTU49_RS07525	COG3537	Alpha-1,2-mannosidase
BTU49_RS07530	COG1609	Transcriptional regulator
BTU49_RS07540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTU49_RS07555	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BTU49_RS07560	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BTU49_RS07565	COG0235	Class ii aldolase
BTU49_RS07570	COG0531	amino acid
BTU49_RS07575	COG0531	amino acid
BTU49_RS07585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTU49_RS07590	COG0277	FAD linked oxidase domain protein
BTU49_RS07610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BTU49_RS07620	COG5001	Diguanylate cyclase
BTU49_RS07620	COG3300	MHYT domain
BTU49_RS07630	COG1024	Enoyl-CoA hydratase
BTU49_RS07640	COG1918	ferrous iron import across plasma membrane
BTU49_RS07640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BTU49_RS07660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BTU49_RS07665	COG0505	Belongs to the CarA family
BTU49_RS07670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BTU49_RS07675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTU49_RS07690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BTU49_RS07710	COG3209	COG3209 Rhs family protein
BTU49_RS07710	COG3209	COG3209 Rhs family protein
BTU49_RS07740	COG0671	phosphoesterase, PA-phosphatase related
BTU49_RS07750	COG3279	Response regulator of the LytR AlgR family
BTU49_RS07755	COG0501	Belongs to the peptidase M48B family
BTU49_RS07770	COG1012	belongs to the aldehyde dehydrogenase family
BTU49_RS07780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BTU49_RS07790	COG2205	protein histidine kinase activity
BTU49_RS07790	COG0784	Response regulator, receiver
BTU49_RS07790	COG2198	Histidine kinase
BTU49_RS07795	COG1024	Enoyl-CoA hydratase
BTU49_RS07800	COG0318	PFAM AMP-dependent synthetase and ligase
BTU49_RS07805	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BTU49_RS07810	COG1012	belongs to the aldehyde dehydrogenase family
BTU49_RS07815	COG1309	transcriptional regulator
BTU49_RS07820	COG4185	zeta toxin
BTU49_RS07835	COG0583	DNA-binding transcription factor activity
BTU49_RS07840	COG2828	Protein conserved in bacteria
BTU49_RS07845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTU49_RS07855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTU49_RS07890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BTU49_RS07900	COG1301	dicarboxylic acid transport
BTU49_RS07910	COG2159	amidohydrolase
BTU49_RS07925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BTU49_RS07935	COG0840	transmembrane signaling receptor activity
BTU49_RS07940	COG0840	transmembrane signaling receptor activity
BTU49_RS07950	COG0835	chemotaxis
BTU49_RS07955	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BTU49_RS07960	COG0840	transmembrane signaling receptor activity
BTU49_RS07970	COG0840	transmembrane signaling receptor activity
BTU49_RS07980	COG0745	RESPONSE REGULATOR receiver
BTU49_RS07990	COG0835	chemotaxis
BTU49_RS08000	COG1360	Flagellar Motor Protein
BTU49_RS08005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BTU49_RS08010	COG0643	Histidine kinase
BTU49_RS08010	COG0784	Response regulator, receiver
BTU49_RS08010	COG2198	Histidine kinase
BTU49_RS08015	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BTU49_RS08045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BTU49_RS08060	COG1987	bacterial-type flagellum assembly
BTU49_RS08070	COG3190	flagellar
BTU49_RS08120	COG1677	Flagellar hook-basal body complex protein FliE
BTU49_RS08150	COG2197	response regulator
BTU49_RS08190	COG1256	bacterial-type flagellum assembly
BTU49_RS08205	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BTU49_RS08215	COG4787	bacterial-type flagellum-dependent cell motility
BTU49_RS08235	COG1815	bacterial-type flagellum-dependent cell motility
BTU49_RS08240	COG0784	Response regulator, receiver
BTU49_RS08240	COG0835	chemotaxis
BTU49_RS08300	COG2915	High frequency lysogenization protein hflD homolog
BTU49_RS08305	COG0482	sulfurtransferase activity
BTU49_RS08320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BTU49_RS08325	COG0542	response to heat
BTU49_RS08365	COG0492	ferredoxin-NADP+ reductase activity
BTU49_RS08370	COG1674	ftsk spoiiie
BTU49_RS08385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BTU49_RS08395	COG2819	hydrolase of the alpha beta superfamily
BTU49_RS08405	COG4558	Periplasmic binding protein
BTU49_RS08410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTU49_RS08415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BTU49_RS08425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTU49_RS08465	COG0583	DNA-binding transcription factor activity
BTU49_RS08495	COG3046	protein related to deoxyribodipyrimidine photolyase
BTU49_RS08500	COG2200	EAL domain
BTU49_RS08505	COG0477	Major facilitator Superfamily
BTU49_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS08525	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS08530	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BTU49_RS08540	COG3387	PFAM Glycoside hydrolase 15-related
BTU49_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS08550	COG4191	Histidine kinase
BTU49_RS08550	COG0784	Response regulator, receiver
BTU49_RS08585	COG3300	MHYT domain
BTU49_RS08585	COG5001	Diguanylate cyclase
BTU49_RS08590	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BTU49_RS08620	COG1064	alcohol dehydrogenase
BTU49_RS08640	COG2814	Major facilitator Superfamily
BTU49_RS08650	COG1228	amidohydrolase
BTU49_RS08660	COG1335	isochorismatase
BTU49_RS08665	COG3708	Transcriptional regulator
BTU49_RS08665	COG2207	Transcriptional regulator
BTU49_RS08675	COG4585	Histidine kinase
BTU49_RS08680	COG2197	response regulator
BTU49_RS08710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTU49_RS08735	COG2862	Uncharacterized protein family, UPF0114
BTU49_RS08795	COG2205	protein histidine kinase activity
BTU49_RS08805	COG0318	PFAM AMP-dependent synthetase and ligase
BTU49_RS08840	COG0477	Major facilitator Superfamily
BTU49_RS08845	COG1309	transcriptional regulator
BTU49_RS08860	COG4774	siderophore transport
BTU49_RS08890	COG0702	epimerase
BTU49_RS08910	COG1063	alcohol dehydrogenase
BTU49_RS08920	COG0322	excinuclease ABC activity
BTU49_RS08945	COG0708	Exodeoxyribonuclease III
BTU49_RS08960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTU49_RS08965	COG4774	siderophore transport
BTU49_RS08985	COG0784	Response regulator, receiver
BTU49_RS08985	COG4191	Histidine kinase
BTU49_RS08990	COG2205	protein histidine kinase activity
BTU49_RS08990	COG0784	Response regulator, receiver
BTU49_RS08990	COG5002	protein histidine kinase activity
BTU49_RS09000	COG2172	sigma factor antagonist activity
BTU49_RS09005	COG1366	Belongs to the anti-sigma-factor antagonist family
BTU49_RS09010	COG1366	Belongs to the anti-sigma-factor antagonist family
BTU49_RS09030	COG4251	negative regulation of phosphorylation
BTU49_RS09035	COG0784	Response regulator, receiver
BTU49_RS09055	COG1595	DNA-templated transcription, initiation
BTU49_RS09070	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BTU49_RS09080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BTU49_RS09130	COG2080	2 iron, 2 sulfur cluster binding
BTU49_RS09135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BTU49_RS09140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BTU49_RS09145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BTU49_RS09150	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BTU49_RS09150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BTU49_RS09170	COG2199	diguanylate cyclase activity
BTU49_RS09175	COG3214	Protein conserved in bacteria
BTU49_RS09190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BTU49_RS09195	COG1285	pathogenesis
BTU49_RS09200	COG4191	Histidine kinase
BTU49_RS09205	COG4566	intracellular signal transduction
BTU49_RS09225	COG0243	molybdopterin cofactor binding
BTU49_RS09250	COG0477	Major facilitator Superfamily
BTU49_RS09275	COG1136	(ABC) transporter
BTU49_RS09290	COG0583	DNA-binding transcription factor activity
BTU49_RS09295	COG1012	belongs to the aldehyde dehydrogenase family
BTU49_RS09300	COG0583	DNA-binding transcription factor activity
BTU49_RS09305	COG0656	L-ascorbic acid biosynthetic process
BTU49_RS09315	COG0583	DNA-binding transcription factor activity
BTU49_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS09340	COG0745	RESPONSE REGULATOR receiver
BTU49_RS09345	COG0642	Histidine kinase
BTU49_RS09370	COG3537	Alpha-1,2-mannosidase
BTU49_RS09385	COG3153	acetyltransferase
BTU49_RS09385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTU49_RS09395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTU49_RS09405	COG0477	Major facilitator Superfamily
BTU49_RS09415	COG3920	Histidine kinase
BTU49_RS09415	COG2202	Pas domain
BTU49_RS09465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BTU49_RS09470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BTU49_RS09480	COG0840	transmembrane signaling receptor activity
BTU49_RS09495	COG4771	TonB-dependent receptor
BTU49_RS09510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTU49_RS09515	COG1120	ATPase activity
BTU49_RS09520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BTU49_RS09530	COG4149	molybdate abc transporter
BTU49_RS09535	COG0725	ABC transporter, periplasmic molybdate-binding protein
BTU49_RS09540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTU49_RS09555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTU49_RS09560	COG2181	nitrate reductase activity
BTU49_RS09565	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BTU49_RS09570	COG1140	nitrate reductase beta subunit
BTU49_RS09575	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BTU49_RS09580	COG2223	nitrite transmembrane transporter activity
BTU49_RS09590	COG0746	molybdenum cofactor guanylyltransferase activity
BTU49_RS09595	COG0314	molybdopterin synthase activity
BTU49_RS09605	COG0303	'Molybdopterin
BTU49_RS09610	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTU49_RS09610	COG0315	cyclic pyranopterin monophosphate synthase activity
BTU49_RS09615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BTU49_RS09675	COG2267	carboxylic ester hydrolase activity
BTU49_RS09680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTU49_RS09685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTU49_RS09690	COG1012	belongs to the aldehyde dehydrogenase family
BTU49_RS09695	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BTU49_RS09700	COG1012	belongs to the aldehyde dehydrogenase family
BTU49_RS09705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTU49_RS09750	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS09755	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BTU49_RS09755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTU49_RS09765	COG1535	isochorismatase
BTU49_RS09765	COG3433	isochorismatase activity
BTU49_RS09770	COG1021	2,3-dihydroxybenzoate-AMP ligase
BTU49_RS09785	COG2409	Drug exporters of the RND superfamily
BTU49_RS09805	COG0583	DNA-binding transcription factor activity
BTU49_RS09820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTU49_RS09850	COG1914	H( )-stimulated, divalent metal cation uptake system
BTU49_RS09865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTU49_RS09870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTU49_RS09880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTU49_RS09910	COG4772	TonB-dependent receptor
BTU49_RS09930	COG5295	Hep Hag repeat protein
BTU49_RS09960	COG4964	Belongs to the GSP D family
BTU49_RS10015	COG2814	Major facilitator Superfamily
BTU49_RS10020	COG1228	amidohydrolase
BTU49_RS10030	COG1335	isochorismatase
BTU49_RS10045	COG3850	Histidine kinase
BTU49_RS10050	COG2197	response regulator
BTU49_RS10065	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BTU49_RS10075	COG0583	DNA-binding transcription factor activity
BTU49_RS10085	COG3161	chorismate lyase activity
BTU49_RS10170	COG2885	chlorophyll binding
BTU49_RS10335	COG1388	LysM domain
BTU49_RS10335	COG0741	lytic transglycosylase activity
BTU49_RS10360	COG0277	FAD linked oxidase domain protein
BTU49_RS10365	COG1304	FMN binding
BTU49_RS10370	COG2186	Transcriptional regulator
BTU49_RS10380	COG1285	pathogenesis
BTU49_RS10390	COG1902	pentaerythritol trinitrate reductase activity
BTU49_RS10465	COG0587	DNA-directed DNA polymerase activity
BTU49_RS10480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BTU49_RS10485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTU49_RS10485	COG0519	Catalyzes the synthesis of GMP from XMP
BTU49_RS10500	COG1595	DNA-templated transcription, initiation
BTU49_RS10510	COG1629	transport
BTU49_RS10510	COG4206	TonB-dependent receptor
BTU49_RS10530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTU49_RS10540	COG0789	Transcriptional regulator
BTU49_RS10655	COG3447	MASE1 domain protein
BTU49_RS10655	COG5001	Diguanylate cyclase
BTU49_RS10655	COG5002	protein histidine kinase activity
BTU49_RS10660	COG2183	response to ionizing radiation
BTU49_RS10685	COG3243	poly(R)-hydroxyalkanoic acid synthase
BTU49_RS10700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BTU49_RS10705	COG0534	Mate efflux family protein
BTU49_RS10725	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BTU49_RS10735	COG0668	transmembrane transport
BTU49_RS10740	COG1902	pentaerythritol trinitrate reductase activity
BTU49_RS10760	COG0456	acetyltransferase
BTU49_RS10780	COG2814	Major facilitator Superfamily
BTU49_RS10805	COG0840	transmembrane signaling receptor activity
BTU49_RS10810	COG3300	MHYT domain
BTU49_RS10810	COG5001	Diguanylate cyclase
BTU49_RS10815	COG3852	Histidine kinase
BTU49_RS10825	COG1309	transcriptional regulator
BTU49_RS10830	COG0745	RESPONSE REGULATOR receiver
BTU49_RS10835	COG0642	Histidine kinase
BTU49_RS10850	COG0577	efflux transmembrane transporter activity
BTU49_RS10850	COG1136	(ABC) transporter
BTU49_RS10870	COG3152	Membrane
BTU49_RS10885	COG1733	regulation of RNA biosynthetic process
BTU49_RS10890	COG0604	alcohol dehydrogenase
BTU49_RS10895	COG0210	DNA helicase
BTU49_RS10910	COG0583	DNA-binding transcription factor activity
BTU49_RS10915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BTU49_RS10925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BTU49_RS10940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BTU49_RS10945	COG0077	Prephenate dehydratase
BTU49_RS10945	COG1605	Chorismate mutase
BTU49_RS10950	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BTU49_RS10990	COG1228	amidohydrolase
BTU49_RS11005	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BTU49_RS11040	COG2957	Belongs to the agmatine deiminase family
BTU49_RS11045	COG0583	DNA-binding transcription factor activity
BTU49_RS11065	COG3537	Alpha-1,2-mannosidase
BTU49_RS11110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BTU49_RS11120	COG4993	Dehydrogenase
BTU49_RS11130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BTU49_RS11150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BTU49_RS11155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTU49_RS11170	COG0359	binds to the 23S rRNA
BTU49_RS11175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BTU49_RS11180	COG0360	Binds together with S18 to 16S ribosomal RNA
BTU49_RS11190	COG0316	Belongs to the HesB IscA family
BTU49_RS11195	COG0017	Asparaginyl-tRNA synthetase
BTU49_RS11210	COG2808	Putative FMN-binding domain
BTU49_RS11215	COG0288	reversible hydration of carbon dioxide
BTU49_RS11225	COG3844	kynureninase activity
BTU49_RS11230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTU49_RS11235	COG2925	Exonuclease
BTU49_RS11245	COG0667	Aldo Keto reductase
BTU49_RS11265	COG2902	Dehydrogenase
BTU49_RS11275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTU49_RS11280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTU49_RS11290	COG1960	acyl-CoA dehydrogenase activity
BTU49_RS11295	COG2226	methyltransferase
BTU49_RS11305	COG0646	methionine synthase
BTU49_RS11305	COG1410	methionine synthase
BTU49_RS11320	COG2900	Belongs to the SlyX family
BTU49_RS11335	COG0386	Belongs to the glutathione peroxidase family
BTU49_RS11345	COG1725	Transcriptional regulator
BTU49_RS11350	COG1131	(ABC) transporter
BTU49_RS11375	COG0114	fumarate hydratase activity
BTU49_RS11385	COG2850	peptidyl-arginine hydroxylation
BTU49_RS11395	COG0567	Dehydrogenase, E1 component
BTU49_RS11415	COG0583	DNA-binding transcription factor activity
BTU49_RS11440	COG3540	Alkaline phosphatase
BTU49_RS11450	COG0305	Participates in initiation and elongation during chromosome replication
BTU49_RS11470	COG0625	glutathione transferase activity
BTU49_RS11490	COG0084	hydrolase, TatD family'
BTU49_RS11495	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BTU49_RS11545	COG1595	DNA-templated transcription, initiation
BTU49_RS11550	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTU49_RS11565	COG0386	Belongs to the glutathione peroxidase family
BTU49_RS11570	COG0339	signal peptide processing
BTU49_RS11575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BTU49_RS11590	COG0705	Rhomboid family
BTU49_RS11595	COG3104	oligopeptide transport
BTU49_RS11605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTU49_RS11625	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BTU49_RS11625	COG0316	Belongs to the HesB IscA family
BTU49_RS11630	COG2154	pterin-4-alpha-carbinolamine dehydratase
BTU49_RS11640	COG0428	transporter
BTU49_RS11650	COG1530	ribonuclease E activity
BTU49_RS11665	COG0395	ABC-type sugar transport system, permease component
BTU49_RS11690	COG1609	Transcriptional regulator
BTU49_RS11695	COG0271	Belongs to the BolA IbaG family
BTU49_RS11700	COG2350	Protein conserved in bacteria
BTU49_RS11705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BTU49_RS11710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BTU49_RS11715	COG1187	pseudouridine synthase activity
BTU49_RS11730	COG0436	Aminotransferase
BTU49_RS11735	COG4133	protoheme IX ABC transporter activity
BTU49_RS11755	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BTU49_RS11760	COG1138	Cytochrome C-type biogenesis protein
BTU49_RS11780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTU49_RS11790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BTU49_RS11795	COG4988	ABC transporter
BTU49_RS11805	COG1294	oxidase, subunit
BTU49_RS11855	COG0726	polysaccharide deacetylase
BTU49_RS11855	COG1649	PFAM Uncharacterised BCR, COG1649
BTU49_RS11860	COG1215	transferase activity, transferring glycosyl groups
BTU49_RS11885	COG0165	Argininosuccinate lyase
BTU49_RS11890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTU49_RS11900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTU49_RS11905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTU49_RS11910	COG0137	argininosuccinate synthase activity
BTU49_RS11915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTU49_RS11930	COG2166	iron-sulfur cluster assembly
BTU49_RS11950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BTU49_RS11985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BTU49_RS11990	COG0402	S-adenosylhomocysteine deaminase activity
BTU49_RS11995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BTU49_RS12000	COG1509	lysine 2,3-aminomutase activity
BTU49_RS12005	COG3300	MHYT domain
BTU49_RS12005	COG5001	Diguanylate cyclase
BTU49_RS12015	COG0483	inositol monophosphate 1-phosphatase activity
BTU49_RS12025	COG0501	Belongs to the peptidase M48B family
BTU49_RS12035	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS12055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BTU49_RS12060	COG0860	N-Acetylmuramoyl-L-alanine amidase
BTU49_RS12070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BTU49_RS12070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BTU49_RS12075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BTU49_RS12080	COG1570	exodeoxyribonuclease VII activity
BTU49_RS12090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BTU49_RS12105	COG4771	TonB-dependent receptor
BTU49_RS12110	COG0840	transmembrane signaling receptor activity
BTU49_RS12160	COG1960	acyl-CoA dehydrogenase activity
BTU49_RS12170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BTU49_RS12185	COG2197	response regulator
BTU49_RS12255	COG1280	lysine exporter protein (LysE YggA)
BTU49_RS12260	COG1794	racemase activity, acting on amino acids and derivatives
BTU49_RS12290	COG0776	regulation of translation
BTU49_RS12300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BTU49_RS12305	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BTU49_RS12310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BTU49_RS12315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BTU49_RS12320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BTU49_RS12325	COG4774	siderophore transport
BTU49_RS12365	COG1185	polyribonucleotide nucleotidyltransferase activity
BTU49_RS12370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BTU49_RS12375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BTU49_RS12380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BTU49_RS12385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BTU49_RS12390	COG0195	Participates in both transcription termination and antitermination
BTU49_RS12395	COG0779	Required for maturation of 30S ribosomal subunits
BTU49_RS12420	COG1007	ATP synthesis coupled electron transport
BTU49_RS12435	COG0713	ATP synthesis coupled electron transport
BTU49_RS12445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTU49_RS12450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BTU49_RS12465	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BTU49_RS12470	COG0649	NAD binding
BTU49_RS12475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTU49_RS12480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTU49_RS12485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTU49_RS12500	COG0149	triose-phosphate isomerase activity
BTU49_RS12510	COG3083	sulfuric ester hydrolase activity
BTU49_RS12515	COG0438	transferase activity, transferring glycosyl groups
BTU49_RS12520	COG0726	polysaccharide deacetylase
BTU49_RS12525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTU49_RS12530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BTU49_RS12535	COG0159	tryptophan synthase activity
BTU49_RS12545	COG0133	tryptophan synthase activity
BTU49_RS12580	COG0135	phosphoribosylanthranilate isomerase activity
BTU49_RS12585	COG0101	tRNA pseudouridine synthase activity
BTU49_RS12600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BTU49_RS12605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTU49_RS12610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BTU49_RS12615	COG2890	protein-(glutamine-N5) methyltransferase activity
BTU49_RS12620	COG1999	signal sequence binding
BTU49_RS12625	COG0688	phosphatidylethanolamine metabolic process
BTU49_RS12640	COG0433	COG0433 Predicted ATPase
BTU49_RS12645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTU49_RS12655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTU49_RS12660	COG0412	Dienelactone hydrolase
BTU49_RS12670	COG0717	Belongs to the dCTP deaminase family
BTU49_RS12675	COG0489	protein tyrosine kinase activity
BTU49_RS12685	COG4771	TonB-dependent receptor
BTU49_RS12690	COG4771	TonB-dependent receptor
BTU49_RS12695	COG3590	peptidase
BTU49_RS12745	COG2311	Membrane
BTU49_RS12750	COG1047	Peptidyl-prolyl cis-trans
BTU49_RS12755	COG0791	NLP P60 protein
BTU49_RS12760	COG0791	NLP P60 protein
BTU49_RS12800	COG1301	dicarboxylic acid transport
BTU49_RS12820	COG1722	exodeoxyribonuclease VII activity
BTU49_RS12825	COG0142	geranyltranstransferase activity
BTU49_RS12835	COG0312	modulator of DNA gyrase
BTU49_RS12840	COG3028	Belongs to the UPF0307 family
BTU49_RS12845	COG0312	modulator of DNA gyrase
BTU49_RS12865	COG2968	Membrane
BTU49_RS12885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BTU49_RS12895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BTU49_RS12910	COG0495	leucyl-tRNA aminoacylation
BTU49_RS12925	COG3118	belongs to the thioredoxin family
BTU49_RS12935	COG4251	negative regulation of phosphorylation
BTU49_RS12935	COG3706	GGDEF domain
BTU49_RS12935	COG5001	Diguanylate cyclase
BTU49_RS12935	COG2203	Gaf domain
BTU49_RS12955	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BTU49_RS12965	COG0346	lactoylglutathione lyase activity
BTU49_RS12975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTU49_RS12975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTU49_RS12985	COG2878	Part of a membrane complex involved in electron transport
BTU49_RS12995	COG0251	oxidation-reduction process
BTU49_RS13000	COG0392	lysyltransferase activity
BTU49_RS13000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BTU49_RS13030	COG2824	Alkylphosphonate utilization operon protein PhnA
BTU49_RS13035	COG0443	Heat shock 70 kDa protein
BTU49_RS13075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BTU49_RS13080	COG3122	Protein conserved in bacteria
BTU49_RS13085	COG1451	nucleotide metabolic process
BTU49_RS13095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTU49_RS13130	COG1960	acyl-CoA dehydrogenase activity
BTU49_RS13140	COG1793	dna ligase
BTU49_RS13145	COG1201	RNA secondary structure unwinding
BTU49_RS13160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTU49_RS13165	COG1278	Cold shock
BTU49_RS13170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BTU49_RS13175	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BTU49_RS13180	COG1472	Belongs to the glycosyl hydrolase 3 family
BTU49_RS13185	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BTU49_RS13190	COG2954	triphosphatase activity
BTU49_RS13200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BTU49_RS13210	COG1381	Involved in DNA repair and RecF pathway recombination
BTU49_RS13215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BTU49_RS13230	COG0681	Belongs to the peptidase S26 family
BTU49_RS13235	COG0481	GTPase activity
BTU49_RS13240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTU49_RS13255	COG1024	Enoyl-CoA hydratase
BTU49_RS13255	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTU49_RS13260	COG1741	Belongs to the pirin family
BTU49_RS13265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BTU49_RS13275	COG1741	Belongs to the pirin family
BTU49_RS13285	COG1966	Carbon starvation protein
BTU49_RS13290	COG2879	small protein
BTU49_RS13310	COG2205	protein histidine kinase activity
BTU49_RS13315	COG0745	RESPONSE REGULATOR receiver
BTU49_RS13350	COG2814	Major facilitator Superfamily
BTU49_RS13355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTU49_RS13355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTU49_RS13365	COG1113	amino acid transport
BTU49_RS13370	COG2207	Transcriptional regulator
BTU49_RS13370	COG1917	Cupin 2, conserved barrel domain protein
BTU49_RS13375	COG0753	catalase activity
BTU49_RS13395	COG0840	transmembrane signaling receptor activity
BTU49_RS13410	COG1376	ErfK ybiS ycfS ynhG family protein
BTU49_RS13415	COG0739	heme binding
BTU49_RS13445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BTU49_RS13455	COG0330	HflC and HflK could
BTU49_RS13460	COG0330	HflC and HflK could
BTU49_RS13465	COG0604	alcohol dehydrogenase
BTU49_RS13475	COG0484	heat shock protein binding
BTU49_RS13480	COG0678	peroxiredoxin activity
BTU49_RS13490	COG4953	penicillin-binding protein 1C
BTU49_RS13495	COG2373	Large extracellular alpha-helical protein
BTU49_RS13500	COG2079	MmgE PrpD family protein
BTU49_RS13505	COG2828	Protein conserved in bacteria
BTU49_RS13510	COG3609	addiction module antidote protein, CC2985 family
BTU49_RS13535	COG3829	transcription factor binding
BTU49_RS13560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTU49_RS13580	COG0477	Major facilitator Superfamily
BTU49_RS13590	COG5002	protein histidine kinase activity
BTU49_RS13590	COG2198	Histidine kinase
BTU49_RS13590	COG0784	Response regulator, receiver
BTU49_RS13595	COG2353	YceI-like domain
BTU49_RS13600	COG3038	cytochrome b561
BTU49_RS13615	COG1760	l-serine dehydratase
BTU49_RS13620	COG2267	carboxylic ester hydrolase activity
BTU49_RS13625	COG0527	aspartate kinase activity
BTU49_RS13625	COG0460	homoserine dehydrogenase
BTU49_RS13630	COG0626	cystathionine gamma-synthase activity
BTU49_RS13635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTU49_RS13640	COG0739	heme binding
BTU49_RS13645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BTU49_RS13650	COG1272	protein, Hemolysin III
BTU49_RS13655	COG2982	Protein involved in outer membrane biogenesis
BTU49_RS13660	COG0517	IMP dehydrogenase activity
BTU49_RS13660	COG0617	tRNA 3'-terminal CCA addition
BTU49_RS13660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BTU49_RS13665	COG0463	Glycosyl transferase, family 2
BTU49_RS13675	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BTU49_RS13690	COG1309	transcriptional regulator
BTU49_RS13735	COG0509	glycine decarboxylation via glycine cleavage system
BTU49_RS13740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BTU49_RS13750	COG0330	HflC and HflK could
BTU49_RS13755	COG2186	Transcriptional regulator
BTU49_RS13775	COG2271	Major facilitator Superfamily
BTU49_RS13780	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS13795	COG1742	UPF0060 membrane protein
BTU49_RS13800	COG3956	TIGRFAM MazG family protein
BTU49_RS13810	COG0494	nUDIX hydrolase
BTU49_RS13820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BTU49_RS13835	COG0643	Histidine kinase
BTU49_RS13835	COG0784	Response regulator, receiver
BTU49_RS13835	COG2198	Histidine kinase
BTU49_RS13840	COG0840	transmembrane signaling receptor activity
BTU49_RS13845	COG0835	chemotaxis
BTU49_RS13860	COG0189	ligase activity
BTU49_RS13870	COG1214	PFAM Peptidase M22, glycoprotease
BTU49_RS13875	COG1199	ATP-dependent helicase activity
BTU49_RS13885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTU49_RS13900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTU49_RS13905	COG1215	transferase activity, transferring glycosyl groups
BTU49_RS13920	COG1643	Atp-dependent helicase
BTU49_RS13925	COG0783	Belongs to the Dps family
BTU49_RS13930	COG0514	ATP-dependent DNA helicase (RecQ)
BTU49_RS14005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BTU49_RS14010	COG0602	queuosine metabolic process
BTU49_RS14020	COG2885	chlorophyll binding
BTU49_RS14045	COG0824	Thioesterase
BTU49_RS14050	COG2255	four-way junction helicase activity
BTU49_RS14060	COG0632	four-way junction helicase activity
BTU49_RS14065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BTU49_RS14070	COG0217	transcriptional regulatory protein
BTU49_RS14090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BTU49_RS14115	COG0488	(ABC) transporter
BTU49_RS14125	COG4651	solute:proton antiporter activity
BTU49_RS14125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BTU49_RS14135	COG0542	response to heat
BTU49_RS14140	COG1595	DNA-templated transcription, initiation
BTU49_RS14150	COG4771	TonB-dependent receptor
BTU49_RS14155	COG1858	cytochrome C peroxidase
BTU49_RS14185	COG0028	Belongs to the TPP enzyme family
BTU49_RS14220	COG3387	PFAM Glycoside hydrolase 15-related
BTU49_RS14225	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BTU49_RS14240	COG0564	pseudouridine synthase activity
BTU49_RS14245	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTU49_RS14250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BTU49_RS14250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTU49_RS14275	COG1132	(ABC) transporter
BTU49_RS14285	COG0045	succinate-CoA ligase (ADP-forming) activity
BTU49_RS14305	COG0463	Glycosyl transferase, family 2
BTU49_RS14310	COG0438	transferase activity, transferring glycosyl groups
BTU49_RS14320	COG0438	transferase activity, transferring glycosyl groups
BTU49_RS14325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BTU49_RS14355	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BTU49_RS14375	COG0628	permease
BTU49_RS14385	COG0642	Histidine kinase
BTU49_RS14390	COG0745	RESPONSE REGULATOR receiver
BTU49_RS14405	COG0189	ligase activity
BTU49_RS14420	COG3240	lipase activity
BTU49_RS14420	COG4625	pathogenesis
BTU49_RS14430	COG2022	thiamine diphosphate biosynthetic process
BTU49_RS14435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BTU49_RS14440	COG3273	potassium ion transport
BTU49_RS14440	COG0471	metal ion transport
BTU49_RS14460	COG1970	mechanosensitive ion channel activity
BTU49_RS14470	COG1115	amino acid carrier protein
BTU49_RS14480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTU49_RS14485	COG1115	amino acid carrier protein
BTU49_RS14495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTU49_RS14515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BTU49_RS14525	COG3588	fructose-bisphosphate aldolase
BTU49_RS14530	COG0469	pyruvate kinase activity
BTU49_RS14540	COG0126	phosphoglycerate kinase activity
BTU49_RS14555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BTU49_RS14560	COG3047	cAMP biosynthetic process
BTU49_RS14605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BTU49_RS14610	COG1301	dicarboxylic acid transport
BTU49_RS14620	COG2304	oxidoreductase activity
BTU49_RS14640	COG0714	Associated with various cellular activities
BTU49_RS14670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BTU49_RS14690	COG0254	rRNA binding
BTU49_RS14695	COG1957	nucleoside hydrolase
BTU49_RS14700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BTU49_RS14710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTU49_RS14715	COG1758	RNA polymerase activity
BTU49_RS14725	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BTU49_RS14740	COG1561	YicC-like family, N-terminal region
BTU49_RS14745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BTU49_RS14750	COG0346	lactoylglutathione lyase activity
BTU49_RS14760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTU49_RS14775	COG0006	proline dipeptidase activity
BTU49_RS14780	COG0006	proline dipeptidase activity
BTU49_RS14785	COG3079	Belongs to the UPF0149 family
BTU49_RS14805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BTU49_RS14815	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BTU49_RS14825	COG2912	Transglutaminase-like superfamily
BTU49_RS14830	COG1773	rubredoxin
BTU49_RS14840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTU49_RS14855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTU49_RS14860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTU49_RS14875	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS14905	COG0671	phosphoesterase, PA-phosphatase related
BTU49_RS14915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTU49_RS14920	COG0563	adenylate kinase activity
BTU49_RS14945	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BTU49_RS14955	COG0848	biopolymer transport protein
BTU49_RS14965	COG2832	Protein of unknown function (DUF454)
BTU49_RS15005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BTU49_RS15015	COG4206	TonB-dependent receptor
BTU49_RS15025	COG0745	RESPONSE REGULATOR receiver
BTU49_RS15035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BTU49_RS15040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTU49_RS15045	COG0405	Gamma-glutamyltransferase
BTU49_RS15050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BTU49_RS15065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BTU49_RS15070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTU49_RS15075	COG2226	methyltransferase
BTU49_RS15090	COG0473	3-isopropylmalate dehydrogenase activity
BTU49_RS15095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTU49_RS15130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTU49_RS15145	COG1538	Outer membrane efflux protein
BTU49_RS15150	COG0531	amino acid
BTU49_RS15155	COG1519	Transferase
BTU49_RS15160	COG1560	Kdo2-lipid A biosynthetic process
BTU49_RS15185	COG4771	TonB-dependent receptor
BTU49_RS15205	COG1301	dicarboxylic acid transport
BTU49_RS15215	COG4191	Histidine kinase
BTU49_RS15240	COG0642	Histidine kinase
BTU49_RS15255	COG2851	Citrate transporter
BTU49_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS15330	COG1162	GTPase activity
BTU49_RS15335	COG0436	Aminotransferase
BTU49_RS15355	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BTU49_RS15370	COG1228	amidohydrolase
BTU49_RS15375	COG0804	urea catabolic process
BTU49_RS15385	COG1307	EDD domain protein, DegV family
BTU49_RS15415	COG0589	response to stress
BTU49_RS15425	COG3706	GGDEF domain
BTU49_RS15425	COG4251	negative regulation of phosphorylation
BTU49_RS15425	COG5001	Diguanylate cyclase
BTU49_RS15425	COG2203	Gaf domain
BTU49_RS15445	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BTU49_RS15460	COG1902	pentaerythritol trinitrate reductase activity
BTU49_RS15475	COG0583	DNA-binding transcription factor activity
BTU49_RS15480	COG1064	alcohol dehydrogenase
BTU49_RS15505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BTU49_RS15510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BTU49_RS15520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTU49_RS15525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTU49_RS15540	COG1522	sequence-specific DNA binding
BTU49_RS15550	COG4773	Receptor
BTU49_RS15555	COG4206	TonB-dependent receptor
BTU49_RS15570	COG0617	tRNA 3'-terminal CCA addition
BTU49_RS15620	COG3468	outer membrane autotransporter barrel domain protein
BTU49_RS15630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BTU49_RS15635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BTU49_RS15640	COG1609	Transcriptional regulator
BTU49_RS15650	COG0837	glucose binding
BTU49_RS15660	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BTU49_RS15680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BTU49_RS15690	COG4191	Histidine kinase
BTU49_RS15695	COG0784	Response regulator, receiver
BTU49_RS15700	COG4251	negative regulation of phosphorylation
BTU49_RS15705	COG2823	Periplasmic or secreted lipoprotein
BTU49_RS15710	COG0673	inositol 2-dehydrogenase activity
BTU49_RS15715	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BTU49_RS15735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BTU49_RS15745	COG2921	Belongs to the UPF0250 family
BTU49_RS15755	COG1686	Belongs to the peptidase S11 family
BTU49_RS15760	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BTU49_RS15765	COG2951	lytic endotransglycosylase activity
BTU49_RS15770	COG0772	Belongs to the SEDS family
BTU49_RS15775	COG0772	Belongs to the SEDS family
BTU49_RS15790	COG1792	Involved in formation and maintenance of cell shape
BTU49_RS15795	COG1077	Cell shape determining protein MreB Mrl
BTU49_RS15800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTU49_RS15815	COG0308	aminopeptidase N
BTU49_RS15820	COG2226	methyltransferase
BTU49_RS15850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTU49_RS15855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTU49_RS15870	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BTU49_RS15890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BTU49_RS15900	COG2832	Protein of unknown function (DUF454)
BTU49_RS15910	COG0436	Aminotransferase
BTU49_RS15915	COG1505	serine-type exopeptidase activity
BTU49_RS15940	COG2011	ABC-type metal ion transport system permease component
BTU49_RS15950	COG0697	spore germination
BTU49_RS15955	COG1666	GTP binding
BTU49_RS15985	COG0339	signal peptide processing
BTU49_RS15995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BTU49_RS16025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTU49_RS16025	COG2205	protein histidine kinase activity
BTU49_RS16030	COG2197	response regulator
BTU49_RS16045	COG0488	(ABC) transporter
BTU49_RS16060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTU49_RS16095	COG3121	Chaperone
BTU49_RS16130	COG5295	Hep Hag repeat protein
BTU49_RS16140	COG1309	transcriptional regulator
BTU49_RS16145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BTU49_RS16155	COG1136	(ABC) transporter
BTU49_RS16160	COG1136	(ABC) transporter
BTU49_RS16160	COG0577	efflux transmembrane transporter activity
BTU49_RS16165	COG1136	(ABC) transporter
BTU49_RS16165	COG0577	efflux transmembrane transporter activity
BTU49_RS16180	COG4191	Histidine kinase
BTU49_RS16190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BTU49_RS16200	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BTU49_RS16205	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BTU49_RS16210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BTU49_RS16215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BTU49_RS16220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTU49_RS16225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BTU49_RS16235	COG0356	it plays a direct role in the translocation of protons across the membrane
BTU49_RS16250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTU49_RS16255	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTU49_RS16275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BTU49_RS16300	COG0181	hydroxymethylbilane synthase activity
BTU49_RS16310	COG0745	RESPONSE REGULATOR receiver
BTU49_RS16310	COG2972	Histidine kinase
BTU49_RS16315	COG0400	carboxylic ester hydrolase activity
BTU49_RS16320	COG2943	transferase activity, transferring hexosyl groups
BTU49_RS16335	COG0840	transmembrane signaling receptor activity
BTU49_RS16355	COG0625	glutathione transferase activity
BTU49_RS16360	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BTU49_RS16400	COG3550	peptidyl-serine autophosphorylation
BTU49_RS16405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BTU49_RS16410	COG1490	D-aminoacyl-tRNA deacylase activity
BTU49_RS16420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BTU49_RS16450	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BTU49_RS16455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTU49_RS16455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTU49_RS16460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BTU49_RS16465	COG0242	peptide deformylase activity
BTU49_RS16470	COG1652	LysM domain
BTU49_RS16475	COG0758	DNA mediated transformation
BTU49_RS16480	COG2922	Belongs to the Smg family
BTU49_RS16495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BTU49_RS16495	COG1754	DNA topoisomerase type I activity
BTU49_RS16500	COG0009	L-threonylcarbamoyladenylate synthase
BTU49_RS16525	COG0616	signal peptide processing
BTU49_RS16530	COG0534	Mate efflux family protein
BTU49_RS16545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BTU49_RS16550	COG0625	glutathione transferase activity
BTU49_RS16560	COG1252	NADH dehydrogenase
BTU49_RS16585	COG2860	membrane
BTU49_RS16600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTU49_RS16615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BTU49_RS16645	COG1846	Transcriptional regulator
BTU49_RS16650	COG0459	protein refolding
BTU49_RS16655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BTU49_RS16660	COG2356	endonuclease I
BTU49_RS16665	COG1324	tolerance protein
BTU49_RS16675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTU49_RS16685	COG0840	transmembrane signaling receptor activity
BTU49_RS16705	COG4585	Histidine kinase
BTU49_RS16730	COG0583	DNA-binding transcription factor activity
BTU49_RS16735	COG1785	Belongs to the alkaline phosphatase family
BTU49_RS16740	COG1686	Belongs to the peptidase S11 family
BTU49_RS16750	COG2249	NAD(P)H dehydrogenase (quinone) activity
BTU49_RS16755	COG4771	TonB-dependent receptor
BTU49_RS16775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BTU49_RS16780	COG0511	ligase activity, forming carbon-carbon bonds
BTU49_RS16785	COG0439	Biotin carboxylase
BTU49_RS16800	COG2264	protein methyltransferase activity
BTU49_RS16810	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BTU49_RS16815	COG4589	Belongs to the CDS family
BTU49_RS16830	COG2453	phosphatase
BTU49_RS16830	COG0671	phosphoesterase, PA-phosphatase related
BTU49_RS16835	COG2267	carboxylic ester hydrolase activity
BTU49_RS16840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BTU49_RS16845	COG0138	bifunctional purine biosynthesis protein purh
BTU49_RS16855	COG0151	Belongs to the GarS family
BTU49_RS16860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BTU49_RS16880	COG2932	Transcriptional regulator
BTU49_RS16885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BTU49_RS16890	COG2201	protein-glutamate methylesterase activity
BTU49_RS16895	COG2177	Part of the ABC transporter FtsEX involved in
BTU49_RS16900	COG2884	Cell division ATP-binding protein ftsE
BTU49_RS16910	COG3118	belongs to the thioredoxin family
BTU49_RS16915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BTU49_RS16925	COG1472	Belongs to the glycosyl hydrolase 3 family
BTU49_RS16930	COG1609	Transcriptional regulator
BTU49_RS16945	COG3706	GGDEF domain
BTU49_RS16960	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BTU49_RS16995	COG1652	LysM domain
BTU49_RS17000	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTU49_RS17000	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTU49_RS17005	COG1473	amidohydrolase
BTU49_RS17010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTU49_RS17015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTU49_RS17030	COG1289	transmembrane transporter activity
BTU49_RS17035	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS17040	COG2814	Major facilitator Superfamily
BTU49_RS17075	COG0316	Belongs to the HesB IscA family
BTU49_RS17120	COG1051	belongs to the nudix hydrolase family
BTU49_RS17135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BTU49_RS17140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BTU49_RS17145	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BTU49_RS17155	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BTU49_RS17160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTU49_RS17165	COG0730	response to heat
BTU49_RS17175	COG0134	indole-3-glycerol-phosphate synthase activity
BTU49_RS17180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BTU49_RS17205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BTU49_RS17210	COG1597	lipid kinase activity
BTU49_RS17225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BTU49_RS17230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BTU49_RS17240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BTU49_RS17240	COG2111	Na H antiporter
BTU49_RS17245	COG1006	Multisubunit Na H antiporter MnhC subunit
BTU49_RS17250	COG0651	ATP synthesis coupled electron transport
BTU49_RS17255	COG1863	multisubunit Na H antiporter MnhE subunit
BTU49_RS17260	COG2212	antiporter activity
BTU49_RS17265	COG1320	monovalent cation:proton antiporter activity
BTU49_RS17285	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BTU49_RS17315	COG3104	oligopeptide transport
BTU49_RS17320	COG3483	tryptophan 2,3-dioxygenase activity
BTU49_RS17325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BTU49_RS17350	COG2378	regulation of single-species biofilm formation
BTU49_RS17355	COG0702	epimerase
BTU49_RS17365	COG2354	Protein conserved in bacteria
BTU49_RS17375	COG1368	sulfuric ester hydrolase activity
BTU49_RS17380	COG3264	Mechanosensitive ion channel
BTU49_RS17380	COG1511	domain protein
BTU49_RS17395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BTU49_RS17410	COG3212	peptidase
BTU49_RS17430	COG1166	arginine decarboxylase activity
BTU49_RS17435	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BTU49_RS17445	COG0596	Alpha beta hydrolase
BTU49_RS17480	COG0577	efflux transmembrane transporter activity
BTU49_RS17500	COG0606	chelatase, subunit chli
BTU49_RS17550	COG0561	phosphatase activity
BTU49_RS17555	COG3932	Exopolysaccharide synthesis, ExoD
BTU49_RS17590	COG1104	cysteine desulfurase activity
BTU49_RS17620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTU49_RS17625	COG2031	fatty acid transporter
BTU49_RS17660	COG0438	transferase activity, transferring glycosyl groups
BTU49_RS17660	COG1216	Glycosyl transferase, family 2
BTU49_RS17665	COG0438	transferase activity, transferring glycosyl groups
BTU49_RS17700	COG0673	inositol 2-dehydrogenase activity
BTU49_RS17705	COG4206	TonB-dependent receptor
BTU49_RS17710	COG1501	Belongs to the glycosyl hydrolase 31 family
BTU49_RS17715	COG2222	sugar isomerase
BTU49_RS17720	COG1940	carbohydrate kinase activity
BTU49_RS17730	COG1349	DNA-binding transcription factor activity
BTU49_RS17735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BTU49_RS17740	COG2814	Major facilitator Superfamily
BTU49_RS17755	COG1040	competence protein
BTU49_RS17765	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS17780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BTU49_RS17785	COG0156	8-amino-7-oxononanoate synthase activity
BTU49_RS17790	COG2267	carboxylic ester hydrolase activity
BTU49_RS17795	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS17810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BTU49_RS17830	COG3541	Predicted nucleotidyltransferase
BTU49_RS17835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BTU49_RS17860	COG0714	Associated with various cellular activities
BTU49_RS17875	COG0754	glutathionylspermidine amidase activity
BTU49_RS17890	COG0129	dihydroxy-acid dehydratase activity
BTU49_RS17900	COG1199	ATP-dependent helicase activity
BTU49_RS17910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BTU49_RS17930	COG3781	membrane
BTU49_RS17970	COG0625	glutathione transferase activity
BTU49_RS17990	COG2207	Transcriptional regulator
BTU49_RS18015	COG4555	ABC transporter
BTU49_RS18060	COG0543	2 iron, 2 sulfur cluster binding
BTU49_RS18060	COG0633	Ferredoxin
BTU49_RS18065	COG1131	(ABC) transporter
BTU49_RS18070	COG0842	Transport permease protein
BTU49_RS18080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BTU49_RS18090	COG0084	hydrolase, TatD family'
BTU49_RS18095	COG1643	Atp-dependent helicase
BTU49_RS18105	COG1187	pseudouridine synthase activity
BTU49_RS18120	COG0667	Aldo Keto reductase
BTU49_RS18125	COG1690	Belongs to the RtcB family
BTU49_RS18140	COG0840	transmembrane signaling receptor activity
BTU49_RS18145	COG0583	DNA-binding transcription factor activity
BTU49_RS18150	COG2814	Major facilitator Superfamily
BTU49_RS18155	COG0656	L-ascorbic acid biosynthetic process
BTU49_RS18160	COG2267	carboxylic ester hydrolase activity
BTU49_RS18165	COG0393	Putative heavy-metal-binding
BTU49_RS18170	COG0045	succinate-CoA ligase (ADP-forming) activity
BTU49_RS18170	COG1042	CoA-binding domain protein
BTU49_RS18170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BTU49_RS18175	COG2239	Acts as a magnesium transporter
BTU49_RS18180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BTU49_RS18180	COG0475	glutathione-regulated potassium exporter activity
BTU49_RS18190	COG3100	YcgL domain-containing protein
BTU49_RS18205	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS18245	COG2986	histidine ammonia-lyase
BTU49_RS18255	COG0463	Glycosyl transferase, family 2
BTU49_RS18270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTU49_RS18275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTU49_RS18290	COG1294	oxidase, subunit
BTU49_RS18295	COG1271	oxidase subunit
BTU49_RS18305	COG1595	DNA-templated transcription, initiation
BTU49_RS18325	COG0494	nUDIX hydrolase
BTU49_RS18335	COG0408	coproporphyrinogen oxidase activity
BTU49_RS18345	COG2323	membrane
BTU49_RS18365	COG0589	response to stress
BTU49_RS18370	COG0430	RNA-3'-phosphate cyclase activity
BTU49_RS18375	COG1690	Belongs to the RtcB family
BTU49_RS18385	COG4650	regulator
BTU49_RS18410	COG0210	DNA helicase
BTU49_RS18420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTU49_RS18425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTU49_RS18430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BTU49_RS18440	COG3734	2-keto-3-deoxy-galactonokinase
BTU49_RS18445	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS18455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTU49_RS18465	COG2271	Major facilitator Superfamily
BTU49_RS18495	COG0251	oxidation-reduction process
BTU49_RS18535	COG0463	Glycosyl transferase, family 2
BTU49_RS18550	COG1475	DNA binding
BTU49_RS18555	COG1192	Involved in chromosome partitioning
BTU49_RS18560	COG0357	Ribosomal RNA small subunit methyltransferase G
BTU49_RS18565	COG2091	lysine biosynthetic process via aminoadipic acid
BTU49_RS18605	COG1971	Probably functions as a manganese efflux pump
BTU49_RS18610	COG2205	protein histidine kinase activity
BTU49_RS18610	COG0784	Response regulator, receiver
BTU49_RS18620	COG0443	Heat shock 70 kDa protein
BTU49_RS18640	COG0729	surface antigen
BTU49_RS18650	COG0752	glycyl-tRNA synthetase alpha subunit
BTU49_RS18655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BTU49_RS18660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTU49_RS18660	COG0519	Catalyzes the synthesis of GMP from XMP
BTU49_RS18670	COG0805	protein transport
BTU49_RS18675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTU49_RS18680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTU49_RS18690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BTU49_RS18700	COG0840	transmembrane signaling receptor activity
BTU49_RS18755	COG3135	benzoate transporter
BTU49_RS18765	COG0676	glucose-6-phosphate 1-epimerase activity
BTU49_RS18770	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BTU49_RS18775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BTU49_RS18810	COG0302	gtp cyclohydrolase
BTU49_RS18850	COG1074	ATP-dependent DNA helicase activity
BTU49_RS18855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BTU49_RS18860	COG1127	ABC transporter
BTU49_RS18865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTU49_RS18870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BTU49_RS18885	COG2853	Lipoprotein
BTU49_RS18890	COG0386	Belongs to the glutathione peroxidase family
BTU49_RS18900	COG1322	Protein conserved in bacteria
BTU49_RS18915	COG0583	DNA-binding transcription factor activity
BTU49_RS18935	COG0667	Aldo Keto reductase
BTU49_RS18940	COG0667	Aldo Keto reductase
BTU49_RS18950	COG0531	amino acid
BTU49_RS18960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BTU49_RS18965	COG0861	Integral membrane protein TerC family
BTU49_RS18980	COG0584	glycerophosphoryl diester phosphodiesterase
BTU49_RS18995	COG0706	membrane insertase activity
BTU49_RS19000	COG0594	ribonuclease P activity
BTU49_RS19005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BTU49_RS19010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BTU49_RS19020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BTU49_RS19025	COG0187	DNA topoisomerase II activity
BTU49_RS19030	COG1266	CAAX protease self-immunity
BTU49_RS19035	COG0501	Belongs to the peptidase M48B family
BTU49_RS19110	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BTU49_RS19120	COG4772	TonB-dependent receptor
BTU49_RS19170	COG0800	Aldolase
BTU49_RS19175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTU49_RS19200	COG2755	lipolytic protein G-D-S-L family
BTU49_RS19205	COG2272	Belongs to the type-B carboxylesterase lipase family
BTU49_RS19220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTU49_RS19240	COG3507	Belongs to the glycosyl hydrolase 43 family
BTU49_RS19245	COG1609	Transcriptional regulator
BTU49_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS19260	COG2755	lipolytic protein G-D-S-L family
BTU49_RS19270	COG3186	Phenylalanine-4-hydroxylase
BTU49_RS19275	COG1522	sequence-specific DNA binding
BTU49_RS19285	COG1752	Esterase of the alpha-beta hydrolase superfamily
BTU49_RS19295	COG4771	TonB-dependent receptor
BTU49_RS19315	COG1122	ATPase activity
BTU49_RS19330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BTU49_RS19340	COG0515	serine threonine protein kinase
BTU49_RS19340	COG2815	serine threonine protein kinase
BTU49_RS19345	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BTU49_RS19355	COG1435	thymidine kinase activity
BTU49_RS19370	COG3132	Protein of unknown function, DUF480
BTU49_RS19375	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BTU49_RS19380	COG0284	orotidine-5'-phosphate decarboxylase activity
BTU49_RS19385	COG5640	endopeptidase activity
BTU49_RS19395	COG2937	Belongs to the GPAT DAPAT family
BTU49_RS19410	COG0037	tRNA processing
BTU49_RS19415	COG2974	May be involved in recombination
BTU49_RS19430	COG1803	Methylglyoxal synthase
BTU49_RS19440	COG0493	'glutamate synthase
BTU49_RS19445	COG0070	glutamate synthase
BTU49_RS19445	COG0067	glutamate synthase
BTU49_RS19445	COG0069	glutamate synthase activity
BTU49_RS19465	COG1028	Short-chain dehydrogenase reductase Sdr
BTU49_RS19500	COG1111	helicase
BTU49_RS19500	COG1205	dead DEAH box helicase
BTU49_RS19535	COG0714	Associated with various cellular activities
BTU49_RS19555	COG0312	modulator of DNA gyrase
BTU49_RS19580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTU49_RS19600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTU49_RS19610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTU49_RS19615	COG0702	epimerase
BTU49_RS19620	COG1234	tRNA 3'-trailer cleavage
BTU49_RS19650	COG1968	undecaprenyl-diphosphatase activity
BTU49_RS19655	COG0174	glutamine synthetase
BTU49_RS19660	COG0347	Belongs to the P(II) protein family
BTU49_RS19665	COG0004	ammonium transporteR
BTU49_RS19675	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BTU49_RS19690	COG3852	Histidine kinase
BTU49_RS19695	COG2204	response regulator
BTU49_RS19700	COG2032	superoxide dismutase activity
BTU49_RS19705	COG2032	superoxide dismutase activity
BTU49_RS19715	COG0183	Belongs to the thiolase family
BTU49_RS19750	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BTU49_RS19755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BTU49_RS19800	COG0625	glutathione transferase activity
BTU49_RS19805	COG0583	DNA-binding transcription factor activity
BTU49_RS19855	COG0583	DNA-binding transcription factor activity
BTU49_RS19860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BTU49_RS19890	COG2807	transmembrane transport
BTU49_RS19905	COG1401	restriction endodeoxyribonuclease activity
BTU49_RS19905	COG1401	restriction endodeoxyribonuclease activity
BTU49_RS19915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BTU49_RS19920	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BTU49_RS19950	COG2837	iron assimilation
BTU49_RS19980	COG2197	response regulator
BTU49_RS19985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTU49_RS19985	COG2205	protein histidine kinase activity
BTU49_RS19990	COG3474	cytochrome
BTU49_RS20000	COG1960	acyl-CoA dehydrogenase activity
BTU49_RS20005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BTU49_RS20015	COG0612	Peptidase, M16
BTU49_RS20025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTU49_RS20030	COG0596	Alpha beta hydrolase
BTU49_RS20040	COG0318	PFAM AMP-dependent synthetase and ligase
BTU49_RS20045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BTU49_RS20055	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTU49_RS20070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BTU49_RS20075	COG0564	pseudouridine synthase activity
BTU49_RS20095	COG0339	signal peptide processing
BTU49_RS20110	COG0681	Belongs to the peptidase S26 family
BTU49_RS20115	COG2814	Major facilitator Superfamily
BTU49_RS20120	COG0583	DNA-binding transcription factor activity
BTU49_RS20125	COG0583	DNA-binding transcription factor activity
BTU49_RS20130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BTU49_RS20135	COG2224	Isocitrate lyase
BTU49_RS20140	COG3447	MASE1 domain protein
BTU49_RS20140	COG5001	Diguanylate cyclase
BTU49_RS20140	COG5002	protein histidine kinase activity
BTU49_RS20165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BTU49_RS20170	COG1960	acyl-CoA dehydrogenase activity
BTU49_RS20190	COG0697	spore germination
BTU49_RS20200	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BTU49_RS20215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTU49_RS20225	COG1280	lysine exporter protein (LysE YggA)
BTU49_RS20230	COG1607	acyl-coa hydrolase
BTU49_RS20240	COG1902	pentaerythritol trinitrate reductase activity
BTU49_RS20260	COG1335	isochorismatase
BTU49_RS20265	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BTU49_RS20270	COG1752	Esterase of the alpha-beta hydrolase superfamily
BTU49_RS20280	COG3800	Transcriptional regulator
BTU49_RS20280	COG1396	sequence-specific DNA binding
BTU49_RS20290	COG1960	acyl-CoA dehydrogenase activity
BTU49_RS20295	COG1024	Enoyl-CoA hydratase
BTU49_RS20300	COG1024	Enoyl-CoA hydratase
BTU49_RS20310	COG1764	response to oxidative stress
BTU49_RS20320	COG0659	secondary active sulfate transmembrane transporter activity
BTU49_RS20330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTU49_RS20350	COG3228	Belongs to the MtfA family
BTU49_RS20360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BTU49_RS20360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BTU49_RS20365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BTU49_RS20380	COG3657	addiction module killer protein
BTU49_RS20425	COG3237	CsbD-like
BTU49_RS20435	COG0180	Tryptophanyl-tRNA synthetase
BTU49_RS20460	COG0477	Major facilitator Superfamily
BTU49_RS20465	COG0697	spore germination
BTU49_RS20475	COG4206	TonB-dependent receptor
BTU49_RS20480	COG1136	(ABC) transporter
BTU49_RS20480	COG0577	efflux transmembrane transporter activity
BTU49_RS20490	COG1136	(ABC) transporter
BTU49_RS20510	COG4585	Histidine kinase
BTU49_RS20515	COG2197	response regulator
BTU49_RS20530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BTU49_RS20535	COG0546	phosphoglycolate phosphatase activity
BTU49_RS20540	COG0628	permease
BTU49_RS20575	COG5507	3-demethylubiquinone-9 3-methyltransferase
BTU49_RS20585	COG2200	EAL domain
BTU49_RS20585	COG2771	luxR family
BTU49_RS20600	COG2814	Major facilitator Superfamily
BTU49_RS20605	COG0583	DNA-binding transcription factor activity
BTU49_RS20610	COG4807	Protein conserved in bacteria
BTU49_RS20620	COG4221	oxidoreductase activity
BTU49_RS20630	COG0018	arginyl-trna synthetase
BTU49_RS20635	COG2003	Belongs to the UPF0758 family
BTU49_RS20640	COG2197	response regulator
BTU49_RS20645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BTU49_RS20650	COG0756	dUTP diphosphatase activity
BTU49_RS20665	COG2205	protein histidine kinase activity
BTU49_RS20675	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BTU49_RS20680	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BTU49_RS20695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BTU49_RS20700	COG0708	Exodeoxyribonuclease III
BTU49_RS20705	COG2211	Major facilitator Superfamily
BTU49_RS20715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BTU49_RS20720	COG0739	heme binding
BTU49_RS20725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BTU49_RS20785	COG2234	aminopeptidase activity
BTU49_RS20795	COG4942	peptidase
BTU49_RS20800	COG0793	Belongs to the peptidase S41A family
BTU49_RS20815	COG2067	long-chain fatty acid transport protein
BTU49_RS20845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BTU49_RS20875	COG3346	SURF1 family
BTU49_RS20890	COG0109	protoheme IX farnesyltransferase activity
BTU49_RS20915	COG0358	DNA primase activity
BTU49_RS20920	COG1295	ribonuclease BN
BTU49_RS20935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BTU49_RS20945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BTU49_RS20950	COG0668	transmembrane transport
BTU49_RS20965	COG2133	pyrroloquinoline quinone binding
BTU49_RS20970	COG4682	membrane
BTU49_RS20980	COG0531	amino acid
BTU49_RS20990	COG1737	Transcriptional regulator
BTU49_RS20995	COG4948	Mandelate Racemase Muconate Lactonizing