locus-tag	class	description
K7569_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K7569_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K7569_RS00020	COG0187	DNA topoisomerase II activity
K7569_RS00030	COG0501	Belongs to the peptidase M48B family
K7569_RS00115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K7569_RS00125	COG4772	TonB-dependent receptor
K7569_RS00160	COG0800	Aldolase
K7569_RS00165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7569_RS00185	COG2272	Belongs to the type-B carboxylesterase lipase family
K7569_RS00200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K7569_RS00215	COG3507	Belongs to the glycosyl hydrolase 43 family
K7569_RS00220	COG1609	Transcriptional regulator
K7569_RS00230	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS00235	COG2755	lipolytic protein G-D-S-L family
K7569_RS00245	COG3186	Phenylalanine-4-hydroxylase
K7569_RS00250	COG1522	sequence-specific DNA binding
K7569_RS00260	COG1752	Esterase of the alpha-beta hydrolase superfamily
K7569_RS00270	COG4771	TonB-dependent receptor
K7569_RS00290	COG1122	ATPase activity
K7569_RS00305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K7569_RS00310	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K7569_RS00320	COG0210	DNA helicase
K7569_RS00340	COG3132	Protein of unknown function, DUF480
K7569_RS00345	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K7569_RS00350	COG0284	orotidine-5'-phosphate decarboxylase activity
K7569_RS00360	COG2937	Belongs to the GPAT DAPAT family
K7569_RS00370	COG0037	tRNA processing
K7569_RS00375	COG2974	May be involved in recombination
K7569_RS00385	COG1803	Methylglyoxal synthase
K7569_RS00390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7569_RS00390	COG2205	protein histidine kinase activity
K7569_RS00395	COG0493	'glutamate synthase
K7569_RS00400	COG0070	glutamate synthase
K7569_RS00400	COG0069	glutamate synthase activity
K7569_RS00400	COG0067	glutamate synthase
K7569_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS00425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7569_RS00450	COG1111	helicase
K7569_RS00450	COG1205	dead DEAH box helicase
K7569_RS00490	COG0714	Associated with various cellular activities
K7569_RS00510	COG0312	modulator of DNA gyrase
K7569_RS00530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K7569_RS00550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7569_RS00575	COG1881	PFAM PEBP family protein
K7569_RS00585	COG1968	undecaprenyl-diphosphatase activity
K7569_RS00590	COG0174	glutamine synthetase
K7569_RS00595	COG0347	Belongs to the P(II) protein family
K7569_RS00600	COG0004	ammonium transporteR
K7569_RS00605	COG3023	N-Acetylmuramoyl-L-alanine amidase
K7569_RS00610	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K7569_RS00625	COG3852	Histidine kinase
K7569_RS00630	COG2204	response regulator
K7569_RS00635	COG2032	superoxide dismutase activity
K7569_RS00640	COG2032	superoxide dismutase activity
K7569_RS00650	COG0183	Belongs to the thiolase family
K7569_RS00685	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K7569_RS00690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K7569_RS00710	COG0798	PFAM Bile acid sodium symporter
K7569_RS00730	COG0431	NADPH-dependent FMN reductase
K7569_RS00765	COG2837	iron assimilation
K7569_RS00805	COG2197	response regulator
K7569_RS00810	COG2205	protein histidine kinase activity
K7569_RS00810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7569_RS00815	COG3474	cytochrome
K7569_RS00825	COG1960	acyl-CoA dehydrogenase activity
K7569_RS00835	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K7569_RS00845	COG0612	Peptidase, M16
K7569_RS00855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7569_RS00860	COG0596	Alpha beta hydrolase
K7569_RS00870	COG0318	PFAM AMP-dependent synthetase and ligase
K7569_RS00875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K7569_RS00885	COG1181	Belongs to the D-alanine--D-alanine ligase family
K7569_RS00925	COG0339	signal peptide processing
K7569_RS00940	COG0681	Belongs to the peptidase S26 family
K7569_RS00945	COG2814	Major facilitator Superfamily
K7569_RS00950	COG0583	DNA-binding transcription factor activity
K7569_RS00965	COG0583	DNA-binding transcription factor activity
K7569_RS00970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K7569_RS00975	COG2224	Isocitrate lyase
K7569_RS01005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7569_RS01010	COG1960	acyl-CoA dehydrogenase activity
K7569_RS01030	COG0697	spore germination
K7569_RS01040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K7569_RS01050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7569_RS01055	COG1280	lysine exporter protein (LysE YggA)
K7569_RS01060	COG1607	acyl-coa hydrolase
K7569_RS01070	COG1902	pentaerythritol trinitrate reductase activity
K7569_RS01085	COG1335	isochorismatase
K7569_RS01090	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K7569_RS01095	COG1752	Esterase of the alpha-beta hydrolase superfamily
K7569_RS01105	COG1396	sequence-specific DNA binding
K7569_RS01105	COG3800	Transcriptional regulator
K7569_RS01115	COG1960	acyl-CoA dehydrogenase activity
K7569_RS01120	COG1024	Enoyl-CoA hydratase
K7569_RS01125	COG1024	Enoyl-CoA hydratase
K7569_RS01135	COG1764	response to oxidative stress
K7569_RS01165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K7569_RS01185	COG3228	Belongs to the MtfA family
K7569_RS01195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K7569_RS01195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K7569_RS01200	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K7569_RS01230	COG3237	CsbD-like
K7569_RS01240	COG0180	Tryptophanyl-tRNA synthetase
K7569_RS01265	COG0477	Major facilitator Superfamily
K7569_RS01270	COG0697	spore germination
K7569_RS01280	COG4206	TonB-dependent receptor
K7569_RS01290	COG1136	(ABC) transporter
K7569_RS01290	COG0577	efflux transmembrane transporter activity
K7569_RS01300	COG1136	(ABC) transporter
K7569_RS01315	COG4585	Histidine kinase
K7569_RS01320	COG2197	response regulator
K7569_RS01335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K7569_RS01345	COG0628	permease
K7569_RS01365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7569_RS01380	COG5507	3-demethylubiquinone-9 3-methyltransferase
K7569_RS01405	COG2814	Major facilitator Superfamily
K7569_RS01410	COG0583	DNA-binding transcription factor activity
K7569_RS01415	COG4807	Protein conserved in bacteria
K7569_RS01425	COG4221	oxidoreductase activity
K7569_RS01435	COG0018	arginyl-trna synthetase
K7569_RS01440	COG2003	Belongs to the UPF0758 family
K7569_RS01450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K7569_RS01455	COG0756	dUTP diphosphatase activity
K7569_RS01470	COG2205	protein histidine kinase activity
K7569_RS01480	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K7569_RS01485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K7569_RS01500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K7569_RS01505	COG0708	Exodeoxyribonuclease III
K7569_RS01510	COG2223	nitrite transmembrane transporter activity
K7569_RS01525	COG0739	heme binding
K7569_RS01530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K7569_RS01590	COG2234	aminopeptidase activity
K7569_RS01600	COG4942	peptidase
K7569_RS01605	COG0793	Belongs to the peptidase S41A family
K7569_RS01620	COG2067	long-chain fatty acid transport protein
K7569_RS01640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K7569_RS01670	COG3346	SURF1 family
K7569_RS01685	COG0109	protoheme IX farnesyltransferase activity
K7569_RS01700	COG0358	DNA primase activity
K7569_RS01705	COG1295	ribonuclease BN
K7569_RS01720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K7569_RS01730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K7569_RS01735	COG0668	transmembrane transport
K7569_RS01750	COG2133	pyrroloquinoline quinone binding
K7569_RS01755	COG4682	membrane
K7569_RS01765	COG0531	amino acid
K7569_RS01775	COG1737	Transcriptional regulator
K7569_RS01780	COG4948	Mandelate Racemase Muconate Lactonizing
K7569_RS01830	COG5383	Protein conserved in bacteria
K7569_RS01840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K7569_RS01845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K7569_RS01875	COG0778	Nitroreductase
K7569_RS01880	COG2353	YceI-like domain
K7569_RS01890	COG2375	cellular response to nickel ion
K7569_RS01920	COG0270	DNA (cytosine-5-)-methyltransferase activity
K7569_RS02055	COG2267	carboxylic ester hydrolase activity
K7569_RS02120	COG0488	(ABC) transporter
K7569_RS02125	COG0583	DNA-binding transcription factor activity
K7569_RS02135	COG2814	Major facilitator Superfamily
K7569_RS02140	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K7569_RS02145	COG1113	amino acid transport
K7569_RS02150	COG0741	lytic transglycosylase activity
K7569_RS02175	COG2764	glyoxalase bleomycin resistance protein dioxygenase
K7569_RS02185	COG5507	3-demethylubiquinone-9 3-methyltransferase
K7569_RS02190	COG4941	Belongs to the sigma-70 factor family
K7569_RS02220	COG3275	phosphorelay sensor kinase activity
K7569_RS02225	COG3279	Response regulator of the LytR AlgR family
K7569_RS02245	COG3590	peptidase
K7569_RS02250	COG5001	Diguanylate cyclase
K7569_RS02255	COG0583	DNA-binding transcription factor activity
K7569_RS02265	COG3384	dioxygenase
K7569_RS02270	COG0025	NhaP-type Na H and K H
K7569_RS02325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7569_RS02340	COG0784	Response regulator, receiver
K7569_RS02340	COG2205	protein histidine kinase activity
K7569_RS02355	COG2813	Specifically methylates the guanine in position
K7569_RS02360	COG1187	pseudouridine synthase activity
K7569_RS02365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7569_RS02375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K7569_RS02385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K7569_RS02400	COG0583	DNA-binding transcription factor activity
K7569_RS02405	COG2226	methyltransferase
K7569_RS02415	COG4206	TonB-dependent receptor
K7569_RS02430	COG1956	GAF domain-containing protein
K7569_RS02435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K7569_RS02440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7569_RS02445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7569_RS02450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7569_RS02450	COG0785	Cytochrome C biogenesis protein
K7569_RS02455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7569_RS02460	COG0745	RESPONSE REGULATOR receiver
K7569_RS02465	COG5002	protein histidine kinase activity
K7569_RS02470	COG2205	protein histidine kinase activity
K7569_RS02475	COG0745	RESPONSE REGULATOR receiver
K7569_RS02480	COG0367	asparagine synthase
K7569_RS02490	COG0720	synthase
K7569_RS02510	COG0513	Belongs to the DEAD box helicase family
K7569_RS02520	COG0625	glutathione transferase activity
K7569_RS02560	COG0626	cystathionine gamma-synthase activity
K7569_RS02610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K7569_RS02615	COG2076	Multidrug Resistance protein
K7569_RS02630	COG0204	Acyl-transferase
K7569_RS02630	COG0318	PFAM AMP-dependent synthetase and ligase
K7569_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS02640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7569_RS02690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7569_RS02695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K7569_RS02730	COG1127	ABC transporter
K7569_RS02735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K7569_RS02750	COG0442	prolyl-tRNA aminoacylation
K7569_RS02760	COG1183	phosphatidylcholine synthase activity
K7569_RS02770	COG0456	acetyltransferase
K7569_RS02780	COG0525	valine-tRNA ligase activity
K7569_RS02790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K7569_RS02800	COG0795	lipopolysaccharide-transporting ATPase activity
K7569_RS02810	COG4974	Belongs to the 'phage' integrase family
K7569_RS02815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K7569_RS02825	COG0047	phosphoribosylformylglycinamidine synthase activity
K7569_RS02825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K7569_RS02830	COG5295	Hep Hag repeat protein
K7569_RS02835	COG1404	Belongs to the peptidase S8 family
K7569_RS02840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K7569_RS02845	COG1459	type II secretion system
K7569_RS02850	COG2165	general secretion pathway protein
K7569_RS02855	COG4970	Tfp pilus assembly protein FimT
K7569_RS02860	COG2165	general secretion pathway protein
K7569_RS02865	COG4795	General secretion pathway protein
K7569_RS02870	COG3156	type II secretion system protein K
K7569_RS02875	COG3166	PFAM Fimbrial assembly family protein
K7569_RS02890	COG1450	Type ii and iii secretion system protein
K7569_RS02900	COG0463	Glycosyl transferase, family 2
K7569_RS02915	COG3539	Fimbrial protein
K7569_RS02945	COG2194	sulfuric ester hydrolase activity
K7569_RS02955	COG1192	Involved in chromosome partitioning
K7569_RS02960	COG1215	transferase activity, transferring glycosyl groups
K7569_RS02965	COG1215	transferase activity, transferring glycosyl groups
K7569_RS02970	COG0457	Tetratricopeptide repeat
K7569_RS02970	COG3118	belongs to the thioredoxin family
K7569_RS02975	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K7569_RS02980	COG2252	PERMEase
K7569_RS02985	COG0488	(ABC) transporter
K7569_RS02995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K7569_RS03010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K7569_RS03015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K7569_RS03015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K7569_RS03045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K7569_RS03050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K7569_RS03060	COG3152	Membrane
K7569_RS03070	COG3121	Chaperone
K7569_RS03080	COG3188	usher protein
K7569_RS03115	COG2755	lipolytic protein G-D-S-L family
K7569_RS03115	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K7569_RS03120	COG0277	FAD linked oxidase domain protein
K7569_RS03125	COG1988	membrane-bound metal-dependent
K7569_RS03165	COG2001	Belongs to the MraZ family
K7569_RS03170	COG0275	rRNA processing
K7569_RS03175	COG3116	cell division
K7569_RS03185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K7569_RS03190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K7569_RS03210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K7569_RS03215	COG1181	Belongs to the D-alanine--D-alanine ligase family
K7569_RS03220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K7569_RS03230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K7569_RS03235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K7569_RS03245	COG0739	heme binding
K7569_RS03250	COG0653	protein targeting
K7569_RS03255	COG0494	nUDIX hydrolase
K7569_RS03265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K7569_RS03275	COG3275	phosphorelay sensor kinase activity
K7569_RS03280	COG3279	Response regulator of the LytR AlgR family
K7569_RS03295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K7569_RS03300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K7569_RS03310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K7569_RS03315	COG1607	acyl-coa hydrolase
K7569_RS03320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K7569_RS03340	COG4106	trans-aconitate 2-methyltransferase activity
K7569_RS03345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K7569_RS03355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7569_RS03360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K7569_RS03365	COG0667	Aldo Keto reductase
K7569_RS03375	COG4771	TonB-dependent receptor
K7569_RS03400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K7569_RS03405	COG4181	ATPase activity
K7569_RS03420	COG0642	Histidine kinase
K7569_RS03430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K7569_RS03435	COG0861	Integral membrane protein TerC family
K7569_RS03440	COG2814	Major facilitator Superfamily
K7569_RS03455	COG1704	LemA family
K7569_RS03470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K7569_RS03475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K7569_RS03485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K7569_RS03490	COG2967	ApaG domain
K7569_RS03495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K7569_RS03500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K7569_RS03505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K7569_RS03510	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K7569_RS03520	COG2096	Adenosyltransferase
K7569_RS03530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7569_RS03535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7569_RS03545	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K7569_RS03565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K7569_RS03575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7569_RS03585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7569_RS03590	COG0583	DNA-binding transcription factor activity
K7569_RS03595	COG3634	alkyl hydroperoxide reductase activity
K7569_RS03615	COG0583	DNA-binding transcription factor activity
K7569_RS03650	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K7569_RS03675	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K7569_RS03690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K7569_RS03695	COG1404	Belongs to the peptidase S8 family
K7569_RS03715	COG1295	ribonuclease BN
K7569_RS03720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7569_RS03735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K7569_RS03740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K7569_RS03755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K7569_RS03765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K7569_RS03770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K7569_RS03775	COG0193	aminoacyl-tRNA hydrolase activity
K7569_RS03780	COG0012	GTP binding
K7569_RS03785	COG4206	TonB-dependent receptor
K7569_RS03815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K7569_RS03830	COG0250	Participates in transcription elongation, termination and antitermination
K7569_RS03835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K7569_RS03840	COG0081	regulation of translation
K7569_RS03845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K7569_RS03850	COG0222	ribosome binding
K7569_RS03855	COG0085	RNA polymerase activity
K7569_RS03860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K7569_RS03865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K7569_RS03870	COG0049	tRNA binding
K7569_RS03875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K7569_RS03880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K7569_RS03885	COG0051	transcription antitermination factor activity, RNA binding
K7569_RS03890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K7569_RS03895	COG0088	Forms part of the polypeptide exit tunnel
K7569_RS03900	COG0089	rRNA binding
K7569_RS03905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K7569_RS03910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K7569_RS03915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K7569_RS03920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K7569_RS03925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K7569_RS03930	COG0255	Belongs to the universal ribosomal protein uL29 family
K7569_RS03935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K7569_RS03940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K7569_RS03945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K7569_RS03950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K7569_RS03955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K7569_RS03960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K7569_RS03965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K7569_RS03970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K7569_RS03975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K7569_RS03980	COG1841	ribosomal large subunit assembly
K7569_RS03985	COG0200	Binds to the 23S rRNA
K7569_RS03990	COG0201	protein transport
K7569_RS03995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K7569_RS04000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K7569_RS04005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K7569_RS04010	COG0202	RNA polymerase activity
K7569_RS04015	COG0203	ribosomal protein L17
K7569_RS04030	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K7569_RS04040	COG0154	amidase activity
K7569_RS04055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K7569_RS04060	COG0039	L-malate dehydrogenase activity
K7569_RS04065	COG0564	pseudouridine synthase activity
K7569_RS04075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7569_RS04090	COG0625	glutathione transferase activity
K7569_RS04100	COG1902	pentaerythritol trinitrate reductase activity
K7569_RS04100	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7569_RS04105	COG2364	Membrane
K7569_RS04110	COG0604	alcohol dehydrogenase
K7569_RS04125	COG1187	pseudouridine synthase activity
K7569_RS04145	COG1063	alcohol dehydrogenase
K7569_RS04155	COG0406	alpha-ribazole phosphatase activity
K7569_RS04160	COG0285	dihydrofolate synthase activity
K7569_RS04180	COG2833	Protein of unknown function (DUF455)
K7569_RS04190	COG3291	Pkd domain containing protein
K7569_RS04195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K7569_RS04205	COG0438	transferase activity, transferring glycosyl groups
K7569_RS04220	COG0248	Ppx GppA phosphatase
K7569_RS04225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K7569_RS04240	COG4783	chaperone-mediated protein folding
K7569_RS04255	COG0473	3-isopropylmalate dehydrogenase activity
K7569_RS04310	COG0544	peptidyl-prolyl cis-trans isomerase activity
K7569_RS04315	COG0740	serine-type endopeptidase activity
K7569_RS04320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K7569_RS04360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K7569_RS04365	COG3942	CHAP domain
K7569_RS04365	COG1388	LysM domain
K7569_RS04370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7569_RS04375	COG2226	methyltransferase
K7569_RS04380	COG0328	RNA-DNA hybrid ribonuclease activity
K7569_RS04385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K7569_RS04390	COG0631	protein serine/threonine phosphatase activity
K7569_RS04405	COG0859	PFAM glycosyl transferase family 9
K7569_RS04410	COG3642	lipopolysaccharide core region biosynthetic process
K7569_RS04415	COG1234	tRNA 3'-trailer cleavage
K7569_RS04425	COG2076	Multidrug Resistance protein
K7569_RS04450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K7569_RS04455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K7569_RS04465	COG0537	adenosine 5'-monophosphoramidase activity
K7569_RS04485	COG0714	Associated with various cellular activities
K7569_RS04500	COG1399	metal-binding, possibly nucleic acid-binding protein
K7569_RS04505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K7569_RS04510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7569_RS04520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K7569_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS04535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7569_RS04540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K7569_RS04545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K7569_RS04550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K7569_RS04580	COG3209	COG3209 Rhs family protein
K7569_RS04605	COG4774	siderophore transport
K7569_RS04615	COG2223	nitrite transmembrane transporter activity
K7569_RS04635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7569_RS04640	COG0697	spore germination
K7569_RS04645	COG0583	DNA-binding transcription factor activity
K7569_RS04650	COG0477	Major facilitator Superfamily
K7569_RS04685	COG0583	DNA-binding transcription factor activity
K7569_RS04695	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K7569_RS04710	COG0667	Aldo Keto reductase
K7569_RS04730	COG0519	Catalyzes the synthesis of GMP from XMP
K7569_RS04735	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K7569_RS04740	COG1678	Uncharacterized ACR, COG1678
K7569_RS04745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K7569_RS04750	COG0540	Belongs to the ATCase OTCase family
K7569_RS04770	COG2239	Acts as a magnesium transporter
K7569_RS04775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K7569_RS04790	COG1660	Displays ATPase and GTPase activities
K7569_RS04795	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K7569_RS04800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K7569_RS04805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K7569_RS04815	COG1137	ATPase activity
K7569_RS04830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K7569_RS04845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K7569_RS04865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K7569_RS04885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K7569_RS04895	COG0628	permease
K7569_RS04905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K7569_RS04915	COG2261	transglycosylase associated protein
K7569_RS04925	COG1555	photosystem II stabilization
K7569_RS04945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K7569_RS04950	COG1477	protein flavinylation
K7569_RS04970	COG4771	TonB-dependent receptor
K7569_RS04980	COG3128	pkhd-type hydroxylase
K7569_RS04990	COG4774	siderophore transport
K7569_RS05000	COG2146	nitrite reductase [NAD(P)H] activity
K7569_RS05070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K7569_RS05075	COG0719	Fe-S assembly protein
K7569_RS05080	COG0396	ATPase activity
K7569_RS05085	COG0719	Fe-S assembly protein
K7569_RS05090	COG1959	2 iron, 2 sulfur cluster binding
K7569_RS05100	COG0693	protein deglycase activity
K7569_RS05125	COG1764	response to oxidative stress
K7569_RS05130	COG0384	phenazine biosynthesis protein PhzF
K7569_RS05135	COG0384	phenazine biosynthesis protein PhzF
K7569_RS05140	COG0527	aspartate kinase activity
K7569_RS05150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K7569_RS05170	COG0142	geranyltranstransferase activity
K7569_RS05175	COG0366	Alpha amylase catalytic
K7569_RS05185	COG1082	Xylose isomerase domain protein TIM barrel
K7569_RS05195	COG2190	(PTS) system
K7569_RS05195	COG2211	Major facilitator Superfamily
K7569_RS05225	COG1131	(ABC) transporter
K7569_RS05240	COG0629	single-stranded DNA binding
K7569_RS05275	COG3039	Transposase
K7569_RS05365	COG2010	Cytochrome c
K7569_RS05375	COG0673	inositol 2-dehydrogenase activity
K7569_RS05380	COG2211	Major facilitator Superfamily
K7569_RS05390	COG1609	Transcriptional regulator
K7569_RS05430	COG3655	Transcriptional regulator
K7569_RS05435	COG1253	flavin adenine dinucleotide binding
K7569_RS05440	COG1408	metallophosphoesterase
K7569_RS05465	COG2259	Doxx family
K7569_RS05490	COG0477	Major facilitator Superfamily
K7569_RS05510	COG1802	Transcriptional regulator
K7569_RS05545	COG3052	prosthetic group binding
K7569_RS05560	COG0579	oxidoreductase
K7569_RS05565	COG0454	-acetyltransferase
K7569_RS05565	COG0456	acetyltransferase
K7569_RS05590	COG3104	oligopeptide transport
K7569_RS05605	COG1297	OPT oligopeptide transporter protein
K7569_RS05610	COG0823	Involved in the tonB-independent uptake of proteins
K7569_RS05610	COG1506	peptidase
K7569_RS05625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K7569_RS05630	COG2894	cell division
K7569_RS05635	COG0850	regulation of cytokinetic process
K7569_RS05645	COG4585	Histidine kinase
K7569_RS05650	COG2197	response regulator
K7569_RS05690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K7569_RS05705	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K7569_RS05715	COG1595	DNA-templated transcription, initiation
K7569_RS05725	COG1946	Acyl-CoA thioesterase
K7569_RS05745	COG0824	Thioesterase
K7569_RS05750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K7569_RS05755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K7569_RS05760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K7569_RS05765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K7569_RS05770	COG0268	Binds directly to 16S ribosomal RNA
K7569_RS05775	COG0728	peptidoglycan biosynthetic process
K7569_RS05780	COG0196	riboflavin kinase activity
K7569_RS05785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K7569_RS05795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K7569_RS05825	COG4206	TonB-dependent receptor
K7569_RS05845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K7569_RS05940	COG2189	Belongs to the N(4) N(6)-methyltransferase family
K7569_RS05950	COG3596	GTP binding
K7569_RS06010	COG0784	Response regulator, receiver
K7569_RS06010	COG4191	Histidine kinase
K7569_RS06025	COG3685	Protein conserved in bacteria
K7569_RS06055	COG1335	isochorismatase
K7569_RS06065	COG3685	Protein conserved in bacteria
K7569_RS06205	COG2200	EAL domain
K7569_RS06235	COG1192	Involved in chromosome partitioning
K7569_RS06330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K7569_RS06390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K7569_RS06395	COG1845	cytochrome c oxidase, subunit III
K7569_RS06400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K7569_RS06415	COG0326	Molecular chaperone. Has ATPase activity
K7569_RS06435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K7569_RS06440	COG2070	2-Nitropropane dioxygenase
K7569_RS06455	COG0228	four-way junction DNA binding
K7569_RS06460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K7569_RS06465	COG0336	Belongs to the RNA methyltransferase TrmD family
K7569_RS06470	COG0335	large ribosomal subunit rRNA binding
K7569_RS06490	COG0534	Mate efflux family protein
K7569_RS06510	COG0753	catalase activity
K7569_RS06525	COG0840	transmembrane signaling receptor activity
K7569_RS06530	COG3134	Outer membrane lipoprotein
K7569_RS06550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7569_RS06570	COG0024	Methionine aminopeptidase
K7569_RS06595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K7569_RS06620	COG1647	Serine aminopeptidase, S33
K7569_RS06625	COG0642	Histidine kinase
K7569_RS06645	COG2814	Major facilitator Superfamily
K7569_RS06650	COG3706	GGDEF domain
K7569_RS06670	COG0588	phosphoglycerate mutase activity
K7569_RS06675	COG3590	peptidase
K7569_RS06685	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K7569_RS06695	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K7569_RS06700	COG0745	RESPONSE REGULATOR receiver
K7569_RS06705	COG2205	protein histidine kinase activity
K7569_RS06710	COG4452	Inner membrane protein CreD
K7569_RS06725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K7569_RS06730	COG0735	belongs to the Fur family
K7569_RS06770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7569_RS06810	COG5001	Diguanylate cyclase
K7569_RS06810	COG5002	protein histidine kinase activity
K7569_RS06815	COG2199	diguanylate cyclase activity
K7569_RS06820	COG1187	pseudouridine synthase activity
K7569_RS06830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K7569_RS06860	COG1132	(ABC) transporter
K7569_RS06925	COG1695	Transcriptional regulator
K7569_RS06945	COG1981	membrane
K7569_RS06950	COG0825	malonyl-CoA metabolic process
K7569_RS06970	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K7569_RS06975	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K7569_RS06990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7569_RS06995	COG0750	zinc metalloprotease
K7569_RS07000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K7569_RS07005	COG0575	Belongs to the CDS family
K7569_RS07010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K7569_RS07015	COG0233	cytoplasmic translational termination
K7569_RS07020	COG0528	UMP kinase activity
K7569_RS07030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K7569_RS07035	COG0052	Belongs to the universal ribosomal protein uS2 family
K7569_RS07055	COG3188	usher protein
K7569_RS07075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K7569_RS07085	COG1393	Belongs to the ArsC family
K7569_RS07090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7569_RS07095	COG0367	asparagine synthase
K7569_RS07100	COG0475	glutathione-regulated potassium exporter activity
K7569_RS07140	COG1566	PFAM secretion protein HlyD family protein
K7569_RS07145	COG2814	Major facilitator Superfamily
K7569_RS07160	COG0583	DNA-binding transcription factor activity
K7569_RS07180	COG0557	exoribonuclease II activity
K7569_RS07190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7569_RS07195	COG1538	Outer membrane efflux protein
K7569_RS07200	COG0577	efflux transmembrane transporter activity
K7569_RS07200	COG1136	(ABC) transporter
K7569_RS07205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7569_RS07225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K7569_RS07230	COG2259	Doxx family
K7569_RS07240	COG3220	belongs to the UPF0276 family
K7569_RS07250	COG0704	Plays a role in the regulation of phosphate uptake
K7569_RS07260	COG0581	inorganic phosphate transmembrane transporter activity
K7569_RS07265	COG0573	inorganic phosphate transmembrane transporter activity
K7569_RS07270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K7569_RS07275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K7569_RS07285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K7569_RS07295	COG1024	Enoyl-CoA hydratase
K7569_RS07305	COG0494	nUDIX hydrolase
K7569_RS07325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K7569_RS07325	COG0116	Belongs to the methyltransferase superfamily
K7569_RS07345	COG2733	membrane
K7569_RS07355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K7569_RS07360	COG1012	belongs to the aldehyde dehydrogenase family
K7569_RS07370	COG0477	Major facilitator Superfamily
K7569_RS07375	COG2703	oxygen carrier activity
K7569_RS07405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7569_RS07410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K7569_RS07415	COG0174	glutamine synthetase
K7569_RS07425	COG2072	flavoprotein involved in K transport
K7569_RS07430	COG3842	ATPase activity
K7569_RS07435	COG1176	ABC-type spermidine putrescine transport system, permease component I
K7569_RS07440	COG1177	transmembrane transport
K7569_RS07445	COG1012	belongs to the aldehyde dehydrogenase family
K7569_RS07460	COG4535	Mg2 and Co2 transporter CorC
K7569_RS07480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K7569_RS07485	COG1702	phosphate starvation-inducible protein PhoH
K7569_RS07495	COG1131	(ABC) transporter
K7569_RS07500	COG0842	Transport permease protein
K7569_RS07505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7569_RS07520	COG0741	lytic transglycosylase activity
K7569_RS07525	COG0723	plastoquinol--plastocyanin reductase activity
K7569_RS07530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K7569_RS07535	COG2857	Cytochrome c1
K7569_RS07540	COG0625	glutathione transferase activity
K7569_RS07545	COG2969	positive regulation of protein catabolic process
K7569_RS07580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7569_RS07590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K7569_RS07605	COG1611	Belongs to the LOG family
K7569_RS07650	COG0556	nucleotide-excision repair
K7569_RS07695	COG0745	RESPONSE REGULATOR receiver
K7569_RS07710	COG0811	peptide transport
K7569_RS07725	COG1663	tetraacyldisaccharide 4'-kinase activity
K7569_RS07730	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K7569_RS07735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7569_RS07745	COG0322	excinuclease ABC activity
K7569_RS07785	COG0577	efflux transmembrane transporter activity
K7569_RS07785	COG1136	(ABC) transporter
K7569_RS07815	COG1397	ADP-ribosylglycohydrolase
K7569_RS07830	COG1917	Cupin 2, conserved barrel domain protein
K7569_RS07830	COG4977	sequence-specific DNA binding
K7569_RS07835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7569_RS07855	COG0348	domain, Protein
K7569_RS07870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K7569_RS07885	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K7569_RS07890	COG0069	glutamate synthase activity
K7569_RS07915	COG1054	Belongs to the UPF0176 family
K7569_RS07920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7569_RS07935	COG1253	flavin adenine dinucleotide binding
K7569_RS07945	COG0306	phosphate transporter
K7569_RS07955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7569_RS07970	COG0504	CTP synthase activity
K7569_RS07975	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K7569_RS07990	COG0148	phosphopyruvate hydratase activity
K7569_RS07995	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K7569_RS08000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K7569_RS08005	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K7569_RS08015	COG2840	Smr protein MutS2
K7569_RS08020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K7569_RS08025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K7569_RS08045	COG1534	Rna-binding protein
K7569_RS08050	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K7569_RS08055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K7569_RS08065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K7569_RS08070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K7569_RS08075	COG1923	regulation of RNA biosynthetic process
K7569_RS08080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K7569_RS08085	COG1546	Belongs to the CinA family
K7569_RS08090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K7569_RS08095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K7569_RS08100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K7569_RS08105	COG2137	regulation of response to DNA damage stimulus
K7569_RS08110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K7569_RS08115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K7569_RS08165	COG3540	Alkaline phosphatase
K7569_RS08180	COG3258	Cytochrome c
K7569_RS08195	COG2223	nitrite transmembrane transporter activity
K7569_RS08205	COG1741	Belongs to the pirin family
K7569_RS08210	COG0583	DNA-binding transcription factor activity
K7569_RS08235	COG0351	phosphomethylpyrimidine kinase
K7569_RS08250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K7569_RS08255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K7569_RS08265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K7569_RS08275	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K7569_RS08280	COG0477	Major facilitator Superfamily
K7569_RS08290	COG0617	tRNA 3'-terminal CCA addition
K7569_RS08295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K7569_RS08300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K7569_RS08305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K7569_RS08310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K7569_RS08315	COG0166	Belongs to the GPI family
K7569_RS08330	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K7569_RS08340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K7569_RS08345	COG0671	phosphoesterase, PA-phosphatase related
K7569_RS08355	COG0800	Aldolase
K7569_RS08360	COG0129	dihydroxy-acid dehydratase activity
K7569_RS08370	COG0837	glucose binding
K7569_RS08395	COG2009	succinate dehydrogenase
K7569_RS08400	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K7569_RS08405	COG1053	succinate dehydrogenase
K7569_RS08425	COG4591	ABC-type transport system involved in lipoprotein release permease component
K7569_RS08440	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K7569_RS08450	COG0552	protein localization to endoplasmic reticulum
K7569_RS08465	COG0742	ribosomal rna small subunit methyltransferase
K7569_RS08470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K7569_RS08480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K7569_RS08485	COG0405	Gamma-glutamyltransferase
K7569_RS08490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7569_RS08500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K7569_RS08520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K7569_RS08530	COG0415	Belongs to the DNA photolyase family
K7569_RS08535	COG2885	chlorophyll binding
K7569_RS08540	COG0583	DNA-binding transcription factor activity
K7569_RS08635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K7569_RS08650	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7569_RS08665	COG0583	DNA-binding transcription factor activity
K7569_RS08670	COG0497	DNA recombination
K7569_RS08675	COG1420	regulation of RNA biosynthetic process
K7569_RS08680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K7569_RS08685	COG0443	Heat shock 70 kDa protein
K7569_RS08690	COG0484	heat shock protein binding
K7569_RS08695	COG2207	Transcriptional regulator
K7569_RS08700	COG2223	nitrite transmembrane transporter activity
K7569_RS08705	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K7569_RS08720	COG1132	(ABC) transporter
K7569_RS08740	COG5001	Diguanylate cyclase
K7569_RS08750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K7569_RS08755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K7569_RS08760	COG0343	queuine tRNA-ribosyltransferase activity
K7569_RS08765	COG1862	Preprotein translocase
K7569_RS08775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7569_RS08780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K7569_RS08790	COG2081	HI0933 family
K7569_RS08795	COG4681	YaeQ
K7569_RS08800	COG0564	pseudouridine synthase activity
K7569_RS08815	COG0625	glutathione transferase activity
K7569_RS08820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K7569_RS08825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K7569_RS08830	COG0513	Belongs to the DEAD box helicase family
K7569_RS08840	COG0583	DNA-binding transcription factor activity
K7569_RS08845	COG0488	(ABC) transporter
K7569_RS08870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7569_RS08885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7569_RS08890	COG2957	Belongs to the agmatine deiminase family
K7569_RS08900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K7569_RS08905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K7569_RS08915	COG0776	regulation of translation
K7569_RS08925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K7569_RS08940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K7569_RS08945	COG0183	Belongs to the thiolase family
K7569_RS08950	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7569_RS08950	COG1024	Enoyl-CoA hydratase
K7569_RS08960	COG0105	UTP biosynthetic process
K7569_RS08965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K7569_RS08975	COG1426	Protein conserved in bacteria
K7569_RS08980	COG2976	Protein conserved in bacteria
K7569_RS08985	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7569_RS08990	COG1160	GTP binding
K7569_RS08995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K7569_RS09000	COG0475	glutathione-regulated potassium exporter activity
K7569_RS09000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K7569_RS09020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7569_RS09020	COG0519	Catalyzes the synthesis of GMP from XMP
K7569_RS09045	COG0583	DNA-binding transcription factor activity
K7569_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS09095	COG0640	Transcriptional regulator
K7569_RS09135	COG0431	NADPH-dependent FMN reductase
K7569_RS09145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7569_RS09150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7569_RS09155	COG1473	amidohydrolase
K7569_RS09170	COG1126	abc transporter atp-binding protein
K7569_RS09175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7569_RS09200	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K7569_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS09220	COG1309	transcriptional regulator
K7569_RS09235	COG0697	spore germination
K7569_RS09240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K7569_RS09245	COG0167	dihydroorotate dehydrogenase activity
K7569_RS09260	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS09265	COG1012	belongs to the aldehyde dehydrogenase family
K7569_RS09275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7569_RS09280	COG0489	protein tyrosine kinase activity
K7569_RS09280	COG3206	protein involved in exopolysaccharide biosynthesis
K7569_RS09285	COG2244	polysaccharide biosynthetic process
K7569_RS09290	COG0438	transferase activity, transferring glycosyl groups
K7569_RS09315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7569_RS09330	COG1596	polysaccharide export
K7569_RS09355	COG0745	RESPONSE REGULATOR receiver
K7569_RS09360	COG0784	Response regulator, receiver
K7569_RS09360	COG4191	Histidine kinase
K7569_RS09365	COG2205	protein histidine kinase activity
K7569_RS09365	COG3437	response regulator, receiver
K7569_RS09365	COG3850	Histidine kinase
K7569_RS09365	COG4999	Histidine kinase
K7569_RS09370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K7569_RS09380	COG2205	protein histidine kinase activity
K7569_RS09380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7569_RS09390	COG0640	Transcriptional regulator
K7569_RS09430	COG0460	homoserine dehydrogenase
K7569_RS09430	COG0527	aspartate kinase activity
K7569_RS09440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K7569_RS09445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7569_RS09450	COG0124	histidyl-tRNA synthetase
K7569_RS09460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K7569_RS09465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K7569_RS09470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7569_RS09475	COG0131	Imidazoleglycerol-phosphate dehydratase
K7569_RS09475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K7569_RS09480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K7569_RS09485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K7569_RS09490	COG0107	imidazoleglycerol-phosphate synthase activity
K7569_RS09495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K7569_RS09495	COG0140	phosphoribosyl-ATP diphosphatase activity
K7569_RS09515	COG1446	asparaginase
K7569_RS09520	COG3142	Participates in the control of copper homeostasis
K7569_RS09525	COG4206	TonB-dependent receptor
K7569_RS09535	COG0789	Transcriptional regulator
K7569_RS09550	COG3537	Alpha-1,2-mannosidase
K7569_RS09555	COG1609	Transcriptional regulator
K7569_RS09565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7569_RS09580	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K7569_RS09585	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K7569_RS09590	COG0235	Class ii aldolase
K7569_RS09595	COG0531	amino acid
K7569_RS09600	COG0531	amino acid
K7569_RS09615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K7569_RS09620	COG0277	FAD linked oxidase domain protein
K7569_RS09635	COG2205	protein histidine kinase activity
K7569_RS09640	COG0745	RESPONSE REGULATOR receiver
K7569_RS09645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7569_RS09650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7569_RS09665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K7569_RS09685	COG1024	Enoyl-CoA hydratase
K7569_RS09710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K7569_RS09715	COG0505	Belongs to the CarA family
K7569_RS09720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K7569_RS09725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7569_RS09740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K7569_RS09745	COG4676	Protein conserved in bacteria
K7569_RS09760	COG3279	Response regulator of the LytR AlgR family
K7569_RS09775	COG1012	belongs to the aldehyde dehydrogenase family
K7569_RS09795	COG2205	protein histidine kinase activity
K7569_RS09795	COG0784	Response regulator, receiver
K7569_RS09795	COG2198	Histidine kinase
K7569_RS09800	COG1024	Enoyl-CoA hydratase
K7569_RS09805	COG0318	PFAM AMP-dependent synthetase and ligase
K7569_RS09810	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K7569_RS09815	COG1012	belongs to the aldehyde dehydrogenase family
K7569_RS09820	COG1309	transcriptional regulator
K7569_RS09825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7569_RS09865	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K7569_RS09875	COG0840	transmembrane signaling receptor activity
K7569_RS09885	COG0346	lactoylglutathione lyase activity
K7569_RS09890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7569_RS09900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K7569_RS09920	COG2203	Gaf domain
K7569_RS09920	COG3706	GGDEF domain
K7569_RS09920	COG4251	negative regulation of phosphorylation
K7569_RS09920	COG5001	Diguanylate cyclase
K7569_RS09930	COG3118	belongs to the thioredoxin family
K7569_RS09940	COG0495	leucyl-tRNA aminoacylation
K7569_RS09955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K7569_RS09965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K7569_RS09990	COG2968	Membrane
K7569_RS10010	COG0312	modulator of DNA gyrase
K7569_RS10015	COG3028	Belongs to the UPF0307 family
K7569_RS10020	COG0312	modulator of DNA gyrase
K7569_RS10030	COG0142	geranyltranstransferase activity
K7569_RS10035	COG1722	exodeoxyribonuclease VII activity
K7569_RS10055	COG1301	dicarboxylic acid transport
K7569_RS10060	COG0791	NLP P60 protein
K7569_RS10065	COG0791	NLP P60 protein
K7569_RS10070	COG1047	Peptidyl-prolyl cis-trans
K7569_RS10075	COG2311	Membrane
K7569_RS10090	COG0697	spore germination
K7569_RS10125	COG3590	peptidase
K7569_RS10130	COG4771	TonB-dependent receptor
K7569_RS10140	COG4771	TonB-dependent receptor
K7569_RS10145	COG4771	TonB-dependent receptor
K7569_RS10150	COG4771	TonB-dependent receptor
K7569_RS10155	COG0489	protein tyrosine kinase activity
K7569_RS10160	COG0717	Belongs to the dCTP deaminase family
K7569_RS10175	COG0412	Dienelactone hydrolase
K7569_RS10185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7569_RS10195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7569_RS10200	COG0433	COG0433 Predicted ATPase
K7569_RS10220	COG0688	phosphatidylethanolamine metabolic process
K7569_RS10225	COG1999	signal sequence binding
K7569_RS10230	COG2890	protein-(glutamine-N5) methyltransferase activity
K7569_RS10235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K7569_RS10240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K7569_RS10245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K7569_RS10260	COG0101	tRNA pseudouridine synthase activity
K7569_RS10265	COG0135	phosphoribosylanthranilate isomerase activity
K7569_RS10280	COG0133	tryptophan synthase activity
K7569_RS10290	COG0159	tryptophan synthase activity
K7569_RS10295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K7569_RS10300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7569_RS10305	COG0726	polysaccharide deacetylase
K7569_RS10310	COG0438	transferase activity, transferring glycosyl groups
K7569_RS10315	COG3119	arylsulfatase activity
K7569_RS10325	COG0149	triose-phosphate isomerase activity
K7569_RS10340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7569_RS10345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7569_RS10350	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7569_RS10355	COG0649	NAD binding
K7569_RS10360	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K7569_RS10375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K7569_RS10380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7569_RS10390	COG0713	ATP synthesis coupled electron transport
K7569_RS10405	COG1007	ATP synthesis coupled electron transport
K7569_RS10420	COG0779	Required for maturation of 30S ribosomal subunits
K7569_RS10425	COG0195	Participates in both transcription termination and antitermination
K7569_RS10430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K7569_RS10435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K7569_RS10445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K7569_RS10450	COG1185	polyribonucleotide nucleotidyltransferase activity
K7569_RS10475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K7569_RS10480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K7569_RS10485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K7569_RS10490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K7569_RS10495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K7569_RS10500	COG0072	phenylalanine-tRNA ligase activity
K7569_RS10500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7569_RS10505	COG0776	regulation of translation
K7569_RS10560	COG1794	racemase activity, acting on amino acids and derivatives
K7569_RS10575	COG0740	serine-type endopeptidase activity
K7569_RS10580	COG1280	lysine exporter protein (LysE YggA)
K7569_RS10585	COG5487	UPF0391 membrane protein
K7569_RS10590	COG2076	Multidrug Resistance protein
K7569_RS10625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K7569_RS10635	COG1960	acyl-CoA dehydrogenase activity
K7569_RS10660	COG2130	NADP-dependent
K7569_RS10665	COG2169	Transcriptional regulator
K7569_RS10665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7569_RS10825	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K7569_RS10870	COG4695	Portal protein
K7569_RS10875	COG0740	serine-type endopeptidase activity
K7569_RS10960	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K7569_RS10995	COG4771	TonB-dependent receptor
K7569_RS11005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K7569_RS11015	COG1570	exodeoxyribonuclease VII activity
K7569_RS11020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K7569_RS11025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K7569_RS11025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K7569_RS11030	COG0802	atpase or kinase
K7569_RS11035	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7569_RS11040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K7569_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS11070	COG0501	Belongs to the peptidase M48B family
K7569_RS11090	COG3300	MHYT domain
K7569_RS11090	COG5001	Diguanylate cyclase
K7569_RS11095	COG1509	lysine 2,3-aminomutase activity
K7569_RS11100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K7569_RS11105	COG0402	S-adenosylhomocysteine deaminase activity
K7569_RS11110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K7569_RS11130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K7569_RS11150	COG2166	iron-sulfur cluster assembly
K7569_RS11165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K7569_RS11170	COG0137	argininosuccinate synthase activity
K7569_RS11175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7569_RS11180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K7569_RS11190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K7569_RS11195	COG0165	Argininosuccinate lyase
K7569_RS11210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K7569_RS11220	COG1215	transferase activity, transferring glycosyl groups
K7569_RS11225	COG0726	polysaccharide deacetylase
K7569_RS11225	COG1649	PFAM Uncharacterised BCR, COG1649
K7569_RS11255	COG1294	oxidase, subunit
K7569_RS11265	COG4988	ABC transporter
K7569_RS11270	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K7569_RS11280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K7569_RS11290	COG3088	subunit of a heme lyase
K7569_RS11290	COG4235	cytochrome complex assembly
K7569_RS11305	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K7569_RS11325	COG4133	protoheme IX ABC transporter activity
K7569_RS11330	COG0436	Aminotransferase
K7569_RS11350	COG2814	Major facilitator Superfamily
K7569_RS11360	COG1187	pseudouridine synthase activity
K7569_RS11365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K7569_RS11370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K7569_RS11375	COG2350	Protein conserved in bacteria
K7569_RS11380	COG0271	Belongs to the BolA IbaG family
K7569_RS11385	COG1609	Transcriptional regulator
K7569_RS11410	COG0395	ABC-type sugar transport system, permease component
K7569_RS11425	COG1530	ribonuclease E activity
K7569_RS11435	COG0428	transporter
K7569_RS11445	COG2154	pterin-4-alpha-carbinolamine dehydratase
K7569_RS11450	COG0316	Belongs to the HesB IscA family
K7569_RS11450	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K7569_RS11465	COG4290	ribonuclease
K7569_RS11470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K7569_RS11480	COG3104	oligopeptide transport
K7569_RS11485	COG0705	Rhomboid family
K7569_RS11505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K7569_RS11515	COG0339	signal peptide processing
K7569_RS11520	COG0386	Belongs to the glutathione peroxidase family
K7569_RS11525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7569_RS11540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7569_RS11545	COG1595	DNA-templated transcription, initiation
K7569_RS11565	COG0625	glutathione transferase activity
K7569_RS11600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K7569_RS11605	COG0084	hydrolase, TatD family'
K7569_RS11625	COG0625	glutathione transferase activity
K7569_RS11645	COG0305	Participates in initiation and elongation during chromosome replication
K7569_RS11665	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7569_RS11670	COG0567	Dehydrogenase, E1 component
K7569_RS11680	COG2850	peptidyl-arginine hydroxylation
K7569_RS11690	COG0114	fumarate hydratase activity
K7569_RS11715	COG1131	(ABC) transporter
K7569_RS11720	COG1725	Transcriptional regulator
K7569_RS11730	COG0386	Belongs to the glutathione peroxidase family
K7569_RS11745	COG2900	Belongs to the SlyX family
K7569_RS11755	COG2755	lipolytic protein G-D-S-L family
K7569_RS11755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K7569_RS11765	COG0646	methionine synthase
K7569_RS11765	COG1410	methionine synthase
K7569_RS11780	COG1960	acyl-CoA dehydrogenase activity
K7569_RS11795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7569_RS11800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7569_RS11810	COG2902	Dehydrogenase
K7569_RS11830	COG0667	Aldo Keto reductase
K7569_RS11840	COG2925	Exonuclease
K7569_RS11845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7569_RS11850	COG3844	kynureninase activity
K7569_RS11860	COG0288	reversible hydration of carbon dioxide
K7569_RS11880	COG0017	Asparaginyl-tRNA synthetase
K7569_RS11885	COG0316	Belongs to the HesB IscA family
K7569_RS11890	COG0360	Binds together with S18 to 16S ribosomal RNA
K7569_RS11895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K7569_RS11900	COG0359	binds to the 23S rRNA
K7569_RS11915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7569_RS11920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K7569_RS11930	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K7569_RS11940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K7569_RS11950	COG4993	Dehydrogenase
K7569_RS12040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K7569_RS12055	COG1228	amidohydrolase
K7569_RS12100	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K7569_RS12105	COG1605	Chorismate mutase
K7569_RS12105	COG0077	Prephenate dehydratase
K7569_RS12110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K7569_RS12125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K7569_RS12135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K7569_RS12140	COG0583	DNA-binding transcription factor activity
K7569_RS12155	COG0210	DNA helicase
K7569_RS12160	COG0604	alcohol dehydrogenase
K7569_RS12165	COG1733	regulation of RNA biosynthetic process
K7569_RS12180	COG4774	siderophore transport
K7569_RS12185	COG0784	Response regulator, receiver
K7569_RS12185	COG4191	Histidine kinase
K7569_RS12205	COG2814	Major facilitator Superfamily
K7569_RS12220	COG3505	Type IV secretory pathway VirD4
K7569_RS12230	COG3736	Type IV secretory pathway, component VirB8
K7569_RS12240	COG2948	multi-organism process
K7569_RS12260	COG3702	type iv secretory pathway
K7569_RS12340	COG0456	acetyltransferase
K7569_RS12345	COG2249	NAD(P)H dehydrogenase (quinone) activity
K7569_RS12350	COG1733	regulation of RNA biosynthetic process
K7569_RS12355	COG0590	tRNA wobble adenosine to inosine editing
K7569_RS12360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K7569_RS12385	COG1902	pentaerythritol trinitrate reductase activity
K7569_RS12390	COG0668	transmembrane transport
K7569_RS12400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K7569_RS12420	COG0534	Mate efflux family protein
K7569_RS12425	COG1073	alpha beta
K7569_RS12425	COG2226	methyltransferase
K7569_RS12440	COG3243	poly(R)-hydroxyalkanoic acid synthase
K7569_RS12475	COG2183	response to ionizing radiation
K7569_RS12480	COG5002	protein histidine kinase activity
K7569_RS12480	COG5001	Diguanylate cyclase
K7569_RS12480	COG3447	MASE1 domain protein
K7569_RS12565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7569_RS12580	COG0531	amino acid
K7569_RS12615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7569_RS12615	COG0519	Catalyzes the synthesis of GMP from XMP
K7569_RS12620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K7569_RS12635	COG0587	DNA-directed DNA polymerase activity
K7569_RS12730	COG1285	pathogenesis
K7569_RS12740	COG2186	Transcriptional regulator
K7569_RS12745	COG1304	FMN binding
K7569_RS12750	COG0277	FAD linked oxidase domain protein
K7569_RS12785	COG3161	chorismate lyase activity
K7569_RS12800	COG0583	DNA-binding transcription factor activity
K7569_RS12810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K7569_RS12820	COG2814	Major facilitator Superfamily
K7569_RS12825	COG2197	response regulator
K7569_RS12830	COG3850	Histidine kinase
K7569_RS12845	COG1335	isochorismatase
K7569_RS12855	COG1228	amidohydrolase
K7569_RS12865	COG2814	Major facilitator Superfamily
K7569_RS12920	COG4964	Belongs to the GSP D family
K7569_RS12965	COG2226	methyltransferase
K7569_RS12985	COG4772	TonB-dependent receptor
K7569_RS12995	COG0583	DNA-binding transcription factor activity
K7569_RS13025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7569_RS13030	COG4206	TonB-dependent receptor
K7569_RS13035	COG0604	alcohol dehydrogenase
K7569_RS13035	COG3321	synthase
K7569_RS13035	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS13045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7569_RS13060	COG1914	H( )-stimulated, divalent metal cation uptake system
K7569_RS13080	COG4771	TonB-dependent receptor
K7569_RS13130	COG2409	Drug exporters of the RND superfamily
K7569_RS13145	COG1021	2,3-dihydroxybenzoate-AMP ligase
K7569_RS13150	COG1535	isochorismatase
K7569_RS13150	COG3433	isochorismatase activity
K7569_RS13155	COG3433	isochorismatase activity
K7569_RS13155	COG1535	isochorismatase
K7569_RS13160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7569_RS13160	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K7569_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS13180	COG2885	chlorophyll binding
K7569_RS13205	COG2194	sulfuric ester hydrolase activity
K7569_RS13215	COG2205	protein histidine kinase activity
K7569_RS13255	COG2207	Transcriptional regulator
K7569_RS13280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K7569_RS13285	COG0521	Mo-molybdopterin cofactor biosynthetic process
K7569_RS13285	COG0315	cyclic pyranopterin monophosphate synthase activity
K7569_RS13290	COG0303	'Molybdopterin
K7569_RS13300	COG0314	molybdopterin synthase activity
K7569_RS13305	COG0746	molybdenum cofactor guanylyltransferase activity
K7569_RS13315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7569_RS13320	COG0725	ABC transporter, periplasmic molybdate-binding protein
K7569_RS13325	COG4149	molybdate abc transporter
K7569_RS13335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K7569_RS13340	COG0840	transmembrane signaling receptor activity
K7569_RS13350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K7569_RS13355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K7569_RS13495	COG0811	peptide transport
K7569_RS13525	COG1335	isochorismatase
K7569_RS13535	COG1335	isochorismatase
K7569_RS13585	COG2202	Pas domain
K7569_RS13585	COG3920	Histidine kinase
K7569_RS13600	COG0477	Major facilitator Superfamily
K7569_RS13620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7569_RS13625	COG3537	Alpha-1,2-mannosidase
K7569_RS13630	COG0642	Histidine kinase
K7569_RS13655	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS13660	COG0583	DNA-binding transcription factor activity
K7569_RS13685	COG0583	DNA-binding transcription factor activity
K7569_RS13725	COG0477	Major facilitator Superfamily
K7569_RS13750	COG0243	molybdopterin cofactor binding
K7569_RS13785	COG4566	intracellular signal transduction
K7569_RS13790	COG4191	Histidine kinase
K7569_RS13795	COG1285	pathogenesis
K7569_RS13800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K7569_RS13820	COG1764	response to oxidative stress
K7569_RS13835	COG4191	Histidine kinase
K7569_RS13845	COG2197	response regulator
K7569_RS13850	COG2197	response regulator
K7569_RS13875	COG3121	Chaperone
K7569_RS13880	COG3188	usher protein
K7569_RS13890	COG3121	Chaperone
K7569_RS13895	COG3121	Chaperone
K7569_RS13915	COG0671	phosphoesterase, PA-phosphatase related
K7569_RS13920	COG4774	siderophore transport
K7569_RS13930	COG3214	Protein conserved in bacteria
K7569_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS13950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7569_RS13955	COG0366	Alpha amylase catalytic
K7569_RS13960	COG0708	Exodeoxyribonuclease III
K7569_RS14040	COG2204	response regulator
K7569_RS14065	COG0583	DNA-binding transcription factor activity
K7569_RS14085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7569_RS14110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7569_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS14125	COG2271	Major facilitator Superfamily
K7569_RS14145	COG2186	Transcriptional regulator
K7569_RS14165	COG0583	DNA-binding transcription factor activity
K7569_RS14170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K7569_RS14190	COG0583	DNA-binding transcription factor activity
K7569_RS14195	COG2828	Protein conserved in bacteria
K7569_RS14210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K7569_RS14235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K7569_RS14260	COG1070	Carbohydrate kinase
K7569_RS14270	COG0477	Major facilitator Superfamily
K7569_RS14275	COG1472	Belongs to the glycosyl hydrolase 3 family
K7569_RS14285	COG3661	Belongs to the glycosyl hydrolase 67 family
K7569_RS14300	COG1472	Belongs to the glycosyl hydrolase 3 family
K7569_RS14305	COG2211	Major facilitator Superfamily
K7569_RS14345	COG1063	alcohol dehydrogenase
K7569_RS14370	COG3685	Protein conserved in bacteria
K7569_RS14375	COG3546	catalase activity
K7569_RS14400	COG3685	Protein conserved in bacteria
K7569_RS14455	COG1309	transcriptional regulator
K7569_RS14475	COG2080	2 iron, 2 sulfur cluster binding
K7569_RS14480	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K7569_RS14485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K7569_RS14490	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K7569_RS14530	COG1022	Amp-dependent synthetase and ligase
K7569_RS14540	COG0300	oxidoreductase activity
K7569_RS14560	COG3300	MHYT domain
K7569_RS14560	COG5001	Diguanylate cyclase
K7569_RS14575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7569_RS14590	COG0456	acetyltransferase
K7569_RS14740	COG4644	lycopene metabolic process
K7569_RS14745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7569_RS14750	COG3039	Transposase
K7569_RS14825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K7569_RS14830	COG1252	NADH dehydrogenase
K7569_RS14860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K7569_RS14865	COG1252	NADH dehydrogenase
K7569_RS14885	COG0556	nucleotide-excision repair
K7569_RS14890	COG3781	membrane
K7569_RS14895	COG4191	Histidine kinase
K7569_RS14900	COG2204	response regulator
K7569_RS14905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K7569_RS14910	COG4149	molybdate abc transporter
K7569_RS14915	COG0725	ABC transporter, periplasmic molybdate-binding protein
K7569_RS14925	COG0746	molybdenum cofactor guanylyltransferase activity
K7569_RS14930	COG0314	molybdopterin synthase activity
K7569_RS14940	COG0303	'Molybdopterin
K7569_RS14945	COG0521	Mo-molybdopterin cofactor biosynthetic process
K7569_RS14945	COG0315	cyclic pyranopterin monophosphate synthase activity
K7569_RS14950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K7569_RS14955	COG0243	molybdopterin cofactor binding
K7569_RS14960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K7569_RS14965	COG1271	oxidase subunit
K7569_RS14970	COG1294	oxidase, subunit
K7569_RS15055	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K7569_RS15065	COG4251	negative regulation of phosphorylation
K7569_RS15070	COG0784	Response regulator, receiver
K7569_RS15090	COG1595	DNA-templated transcription, initiation
K7569_RS15105	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
K7569_RS15115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K7569_RS15145	COG5002	protein histidine kinase activity
K7569_RS15145	COG0784	Response regulator, receiver
K7569_RS15160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K7569_RS15170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K7569_RS15175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7569_RS15180	COG4558	Periplasmic binding protein
K7569_RS15190	COG2819	hydrolase of the alpha beta superfamily
K7569_RS15200	COG3152	Membrane
K7569_RS15205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K7569_RS15225	COG1674	ftsk spoiiie
K7569_RS15230	COG0492	ferredoxin-NADP+ reductase activity
K7569_RS15265	COG0542	response to heat
K7569_RS15275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K7569_RS15290	COG0482	sulfurtransferase activity
K7569_RS15295	COG2915	High frequency lysogenization protein hflD homolog
K7569_RS15340	COG5002	protein histidine kinase activity
K7569_RS15360	COG0835	chemotaxis
K7569_RS15360	COG0784	Response regulator, receiver
K7569_RS15365	COG1815	bacterial-type flagellum-dependent cell motility
K7569_RS15370	COG1558	bacterial-type flagellum-dependent cell motility
K7569_RS15385	COG4787	bacterial-type flagellum-dependent cell motility
K7569_RS15395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K7569_RS15410	COG1256	bacterial-type flagellum assembly
K7569_RS15435	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K7569_RS15455	COG2197	response regulator
K7569_RS15475	COG1677	Flagellar hook-basal body complex protein FliE
K7569_RS15525	COG3190	flagellar
K7569_RS15535	COG1987	bacterial-type flagellum assembly
K7569_RS15550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K7569_RS15555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K7569_RS15580	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K7569_RS15585	COG0643	Histidine kinase
K7569_RS15585	COG0784	Response regulator, receiver
K7569_RS15585	COG2198	Histidine kinase
K7569_RS15590	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K7569_RS15595	COG1360	Flagellar Motor Protein
K7569_RS15605	COG0835	chemotaxis
K7569_RS15615	COG0745	RESPONSE REGULATOR receiver
K7569_RS15625	COG0840	transmembrane signaling receptor activity
K7569_RS15630	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K7569_RS15635	COG0835	chemotaxis
K7569_RS15645	COG0840	transmembrane signaling receptor activity
K7569_RS15660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7569_RS15660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7569_RS15670	COG2878	Part of a membrane complex involved in electron transport
K7569_RS15675	COG0251	oxidation-reduction process
K7569_RS15680	COG0392	lysyltransferase activity
K7569_RS15680	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K7569_RS15710	COG2824	Alkylphosphonate utilization operon protein PhnA
K7569_RS15715	COG0443	Heat shock 70 kDa protein
K7569_RS15765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K7569_RS15770	COG3122	Protein conserved in bacteria
K7569_RS15775	COG1451	nucleotide metabolic process
K7569_RS15785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7569_RS15805	COG0183	Belongs to the thiolase family
K7569_RS15820	COG1960	acyl-CoA dehydrogenase activity
K7569_RS15830	COG1793	dna ligase
K7569_RS15835	COG1201	RNA secondary structure unwinding
K7569_RS15850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7569_RS15855	COG1278	Cold shock
K7569_RS15860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K7569_RS15865	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K7569_RS15870	COG1472	Belongs to the glycosyl hydrolase 3 family
K7569_RS15875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K7569_RS15880	COG2954	triphosphatase activity
K7569_RS15885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K7569_RS15890	COG0745	RESPONSE REGULATOR receiver
K7569_RS15895	COG1381	Involved in DNA repair and RecF pathway recombination
K7569_RS15900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K7569_RS15915	COG0681	Belongs to the peptidase S26 family
K7569_RS15920	COG0481	GTPase activity
K7569_RS15925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7569_RS15945	COG1741	Belongs to the pirin family
K7569_RS15950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K7569_RS15960	COG1741	Belongs to the pirin family
K7569_RS15965	COG1966	Carbon starvation protein
K7569_RS15970	COG2879	small protein
K7569_RS15980	COG2205	protein histidine kinase activity
K7569_RS15985	COG0745	RESPONSE REGULATOR receiver
K7569_RS16020	COG2814	Major facilitator Superfamily
K7569_RS16025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K7569_RS16025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K7569_RS16035	COG1113	amino acid transport
K7569_RS16040	COG2207	Transcriptional regulator
K7569_RS16040	COG1917	Cupin 2, conserved barrel domain protein
K7569_RS16045	COG0753	catalase activity
K7569_RS16060	COG1376	ErfK ybiS ycfS ynhG family protein
K7569_RS16065	COG0739	heme binding
K7569_RS16070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K7569_RS16080	COG0330	HflC and HflK could
K7569_RS16085	COG0330	HflC and HflK could
K7569_RS16090	COG0604	alcohol dehydrogenase
K7569_RS16100	COG0484	heat shock protein binding
K7569_RS16105	COG0678	peroxiredoxin activity
K7569_RS16115	COG4953	penicillin-binding protein 1C
K7569_RS16120	COG2373	Large extracellular alpha-helical protein
K7569_RS16125	COG2079	MmgE PrpD family protein
K7569_RS16130	COG2828	Protein conserved in bacteria
K7569_RS16155	COG0259	pyridoxamine-phosphate oxidase activity
K7569_RS16170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K7569_RS16190	COG0477	Major facilitator Superfamily
K7569_RS16210	COG3038	cytochrome b561
K7569_RS16225	COG1760	l-serine dehydratase
K7569_RS16230	COG2267	carboxylic ester hydrolase activity
K7569_RS16235	COG0460	homoserine dehydrogenase
K7569_RS16235	COG0527	aspartate kinase activity
K7569_RS16240	COG0626	cystathionine gamma-synthase activity
K7569_RS16245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K7569_RS16250	COG0739	heme binding
K7569_RS16255	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K7569_RS16260	COG1272	protein, Hemolysin III
K7569_RS16275	COG0463	Glycosyl transferase, family 2
K7569_RS16280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7569_RS16285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K7569_RS16295	COG4206	TonB-dependent receptor
K7569_RS16300	COG1309	transcriptional regulator
K7569_RS16310	COG1960	acyl-CoA dehydrogenase activity
K7569_RS16340	COG0509	glycine decarboxylation via glycine cleavage system
K7569_RS16345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K7569_RS16355	COG0330	HflC and HflK could
K7569_RS16365	COG1742	UPF0060 membrane protein
K7569_RS16370	COG3956	TIGRFAM MazG family protein
K7569_RS16375	COG1218	3'(2'),5'-bisphosphate nucleotidase
K7569_RS16380	COG0494	nUDIX hydrolase
K7569_RS16390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K7569_RS16405	COG2198	Histidine kinase
K7569_RS16405	COG0784	Response regulator, receiver
K7569_RS16405	COG0643	Histidine kinase
K7569_RS16410	COG0840	transmembrane signaling receptor activity
K7569_RS16415	COG0835	chemotaxis
K7569_RS16430	COG0189	ligase activity
K7569_RS16445	COG1199	ATP-dependent helicase activity
K7569_RS16455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7569_RS16460	COG1216	Glycosyl transferase, family 2
K7569_RS16470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7569_RS16480	COG1643	Atp-dependent helicase
K7569_RS16485	COG0783	Belongs to the Dps family
K7569_RS16490	COG0514	ATP-dependent DNA helicase (RecQ)
K7569_RS16500	COG2132	Multicopper oxidase
K7569_RS16835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K7569_RS16840	COG0602	queuosine metabolic process
K7569_RS16850	COG2885	chlorophyll binding
K7569_RS16855	COG0823	Involved in the tonB-independent uptake of proteins
K7569_RS16870	COG0811	peptide transport
K7569_RS16875	COG0824	Thioesterase
K7569_RS16880	COG2255	four-way junction helicase activity
K7569_RS16890	COG0632	four-way junction helicase activity
K7569_RS16895	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K7569_RS16900	COG0217	transcriptional regulatory protein
K7569_RS16920	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K7569_RS16950	COG0488	(ABC) transporter
K7569_RS16975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K7569_RS16975	COG4651	solute:proton antiporter activity
K7569_RS16985	COG0745	RESPONSE REGULATOR receiver
K7569_RS16990	COG2205	protein histidine kinase activity
K7569_RS17005	COG0542	response to heat
K7569_RS17025	COG0028	Belongs to the TPP enzyme family
K7569_RS17050	COG3387	PFAM Glycoside hydrolase 15-related
K7569_RS17055	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
K7569_RS17060	COG3011	Protein conserved in bacteria
K7569_RS17075	COG0564	pseudouridine synthase activity
K7569_RS17080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7569_RS17090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7569_RS17090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K7569_RS17095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K7569_RS17100	COG0045	succinate-CoA ligase (ADP-forming) activity
K7569_RS17130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K7569_RS17150	COG0745	RESPONSE REGULATOR receiver
K7569_RS17165	COG0189	ligase activity
K7569_RS17195	COG3240	lipase activity
K7569_RS17195	COG4625	pathogenesis
K7569_RS17205	COG2022	thiamine diphosphate biosynthetic process
K7569_RS17210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K7569_RS17215	COG0471	metal ion transport
K7569_RS17215	COG3273	potassium ion transport
K7569_RS17235	COG1970	mechanosensitive ion channel activity
K7569_RS17245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7569_RS17250	COG1115	amino acid carrier protein
K7569_RS17260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7569_RS17265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7569_RS17290	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K7569_RS17300	COG3588	fructose-bisphosphate aldolase
K7569_RS17305	COG0469	pyruvate kinase activity
K7569_RS17315	COG0126	phosphoglycerate kinase activity
K7569_RS17340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K7569_RS17350	COG5001	Diguanylate cyclase
K7569_RS17350	COG3300	MHYT domain
K7569_RS17390	COG3093	addiction module antidote protein HigA
K7569_RS17400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K7569_RS17405	COG1301	dicarboxylic acid transport
K7569_RS17435	COG0714	Associated with various cellular activities
K7569_RS17465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K7569_RS17505	COG3111	PFAM Bacterial OB fold (BOF) protein
K7569_RS17520	COG0254	rRNA binding
K7569_RS17530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K7569_RS17540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7569_RS17545	COG1758	RNA polymerase activity
K7569_RS17560	COG0437	4 iron, 4 sulfur cluster binding
K7569_RS17565	COG2864	formate dehydrogenase
K7569_RS17575	COG1921	L-seryl-tRNASec selenium transferase activity
K7569_RS17580	COG3276	selenocysteine insertion sequence binding
K7569_RS17590	COG0709	Synthesizes selenophosphate from selenide and ATP
K7569_RS17595	COG1561	YicC-like family, N-terminal region
K7569_RS17600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K7569_RS17605	COG0346	lactoylglutathione lyase activity
K7569_RS17615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K7569_RS17630	COG0006	proline dipeptidase activity
K7569_RS17635	COG0006	proline dipeptidase activity
K7569_RS17640	COG3079	Belongs to the UPF0149 family
K7569_RS17660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K7569_RS17670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K7569_RS17680	COG2912	Transglutaminase-like superfamily
K7569_RS17685	COG1773	rubredoxin
K7569_RS17695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K7569_RS17700	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K7569_RS17710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K7569_RS17715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7569_RS17730	COG4221	oxidoreductase activity
K7569_RS17750	COG0671	phosphoesterase, PA-phosphatase related
K7569_RS17760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K7569_RS17765	COG0563	adenylate kinase activity
K7569_RS17790	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K7569_RS17805	COG0848	biopolymer transport protein
K7569_RS17815	COG2832	Protein of unknown function (DUF454)
K7569_RS17850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K7569_RS17860	COG4206	TonB-dependent receptor
K7569_RS17870	COG0745	RESPONSE REGULATOR receiver
K7569_RS17880	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K7569_RS17885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7569_RS17890	COG0405	Gamma-glutamyltransferase
K7569_RS17895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K7569_RS17915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K7569_RS17920	COG2226	methyltransferase
K7569_RS17935	COG0473	3-isopropylmalate dehydrogenase activity
K7569_RS17950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7569_RS17955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7569_RS17970	COG1538	Outer membrane efflux protein
K7569_RS17980	COG1519	Transferase
K7569_RS17985	COG1560	Kdo2-lipid A biosynthetic process
K7569_RS18025	COG1301	dicarboxylic acid transport
K7569_RS18035	COG4191	Histidine kinase
K7569_RS18050	COG0642	Histidine kinase
K7569_RS18065	COG2851	Citrate transporter
K7569_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS18085	COG1162	GTPase activity
K7569_RS18090	COG0436	Aminotransferase
K7569_RS18110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K7569_RS18130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K7569_RS18135	COG0804	urea catabolic process
K7569_RS18145	COG1307	EDD domain protein, DegV family
K7569_RS18155	COG4251	negative regulation of phosphorylation
K7569_RS18155	COG2203	Gaf domain
K7569_RS18155	COG3706	GGDEF domain
K7569_RS18155	COG5001	Diguanylate cyclase
K7569_RS18160	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K7569_RS18170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K7569_RS18190	COG1902	pentaerythritol trinitrate reductase activity
K7569_RS18215	COG0583	DNA-binding transcription factor activity
K7569_RS18220	COG1064	alcohol dehydrogenase
K7569_RS18240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K7569_RS18245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K7569_RS18260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K7569_RS18275	COG1522	sequence-specific DNA binding
K7569_RS18285	COG4773	Receptor
K7569_RS18290	COG4206	TonB-dependent receptor
K7569_RS18310	COG0617	tRNA 3'-terminal CCA addition
K7569_RS18320	COG3209	COG3209 Rhs family protein
K7569_RS18360	COG3468	outer membrane autotransporter barrel domain protein
K7569_RS18370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K7569_RS18375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7569_RS18380	COG1609	Transcriptional regulator
K7569_RS18390	COG0837	glucose binding
K7569_RS18400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K7569_RS18420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K7569_RS18430	COG4191	Histidine kinase
K7569_RS18435	COG0784	Response regulator, receiver
K7569_RS18440	COG4251	negative regulation of phosphorylation
K7569_RS18445	COG2823	Periplasmic or secreted lipoprotein
K7569_RS18450	COG0673	inositol 2-dehydrogenase activity
K7569_RS18455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K7569_RS18475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K7569_RS18480	COG0321	lipoyl(octanoyl) transferase activity
K7569_RS18485	COG2921	Belongs to the UPF0250 family
K7569_RS18495	COG1686	Belongs to the peptidase S11 family
K7569_RS18505	COG2951	lytic endotransglycosylase activity
K7569_RS18510	COG0772	Belongs to the SEDS family
K7569_RS18515	COG0772	Belongs to the SEDS family
K7569_RS18530	COG1792	Involved in formation and maintenance of cell shape
K7569_RS18535	COG1077	Cell shape determining protein MreB Mrl
K7569_RS18540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7569_RS18555	COG0308	aminopeptidase N
K7569_RS18560	COG2226	methyltransferase
K7569_RS18590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7569_RS18595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7569_RS18605	COG0673	inositol 2-dehydrogenase activity
K7569_RS18615	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K7569_RS18630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K7569_RS18640	COG2832	Protein of unknown function (DUF454)
K7569_RS18650	COG0436	Aminotransferase
K7569_RS18655	COG1505	serine-type exopeptidase activity
K7569_RS18670	COG2011	ABC-type metal ion transport system permease component
K7569_RS18680	COG0697	spore germination
K7569_RS18685	COG1666	GTP binding
K7569_RS18715	COG0339	signal peptide processing
K7569_RS18725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7569_RS18740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K7569_RS18740	COG0517	IMP dehydrogenase activity
K7569_RS18745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7569_RS18755	COG1136	(ABC) transporter
K7569_RS18760	COG0577	efflux transmembrane transporter activity
K7569_RS18760	COG1136	(ABC) transporter
K7569_RS18765	COG0577	efflux transmembrane transporter activity
K7569_RS18780	COG4191	Histidine kinase
K7569_RS18790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K7569_RS18815	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K7569_RS18820	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K7569_RS18825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K7569_RS18830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K7569_RS18835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K7569_RS18840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K7569_RS18850	COG0356	it plays a direct role in the translocation of protons across the membrane
K7569_RS18865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K7569_RS18870	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7569_RS18890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K7569_RS18920	COG0181	hydroxymethylbilane synthase activity
K7569_RS18930	COG3275	phosphorelay sensor kinase activity
K7569_RS18945	COG4771	TonB-dependent receptor
K7569_RS19010	COG0625	glutathione transferase activity
K7569_RS19025	COG2259	Doxx family
K7569_RS19050	COG3550	peptidyl-serine autophosphorylation
K7569_RS19055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K7569_RS19060	COG1490	D-aminoacyl-tRNA deacylase activity
K7569_RS19105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K7569_RS19105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K7569_RS19110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K7569_RS19115	COG0242	peptide deformylase activity
K7569_RS19125	COG0758	DNA mediated transformation
K7569_RS19130	COG2922	Belongs to the Smg family
K7569_RS19140	COG1714	RDD family
K7569_RS19145	COG1754	DNA topoisomerase type I activity
K7569_RS19145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K7569_RS19150	COG0009	L-threonylcarbamoyladenylate synthase
K7569_RS19165	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS19175	COG0616	signal peptide processing
K7569_RS19180	COG0534	Mate efflux family protein
K7569_RS19195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K7569_RS19200	COG0625	glutathione transferase activity
K7569_RS19215	COG1252	NADH dehydrogenase
K7569_RS19230	COG2860	membrane
K7569_RS19235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K7569_RS19255	COG1846	Transcriptional regulator
K7569_RS19270	COG0459	protein refolding
K7569_RS19275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K7569_RS19280	COG2356	endonuclease I
K7569_RS19285	COG1324	tolerance protein
K7569_RS19290	COG4232	protein-disulfide reductase activity
K7569_RS19295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7569_RS19305	COG0840	transmembrane signaling receptor activity
K7569_RS19330	COG0583	DNA-binding transcription factor activity
K7569_RS19345	COG1686	Belongs to the peptidase S11 family
K7569_RS19355	COG2249	NAD(P)H dehydrogenase (quinone) activity
K7569_RS19365	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K7569_RS19375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K7569_RS19380	COG0511	ligase activity, forming carbon-carbon bonds
K7569_RS19385	COG0439	Biotin carboxylase
K7569_RS19400	COG2264	protein methyltransferase activity
K7569_RS19410	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K7569_RS19415	COG4589	Belongs to the CDS family
K7569_RS19420	COG0204	Acyl-transferase
K7569_RS19430	COG0671	phosphoesterase, PA-phosphatase related
K7569_RS19430	COG2453	phosphatase
K7569_RS19435	COG2267	carboxylic ester hydrolase activity
K7569_RS19440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K7569_RS19445	COG0138	bifunctional purine biosynthesis protein purh
K7569_RS19450	COG0151	Belongs to the GarS family
K7569_RS19460	COG3209	COG3209 Rhs family protein
K7569_RS19465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K7569_RS19470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K7569_RS19475	COG2201	protein-glutamate methylesterase activity
K7569_RS19480	COG2177	Part of the ABC transporter FtsEX involved in
K7569_RS19485	COG2884	Cell division ATP-binding protein ftsE
K7569_RS19495	COG3118	belongs to the thioredoxin family
K7569_RS19500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K7569_RS19505	COG3706	GGDEF domain
K7569_RS19515	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
K7569_RS19545	COG3209	COG3209 Rhs family protein
K7569_RS19555	COG1652	LysM domain
K7569_RS19560	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K7569_RS19560	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K7569_RS19565	COG1473	amidohydrolase
K7569_RS19570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7569_RS19575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7569_RS19580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7569_RS19590	COG1289	transmembrane transporter activity
K7569_RS19595	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS19600	COG2814	Major facilitator Superfamily
K7569_RS19630	COG0316	Belongs to the HesB IscA family
K7569_RS19670	COG1051	belongs to the nudix hydrolase family
K7569_RS19685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K7569_RS19690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K7569_RS19695	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K7569_RS19705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K7569_RS19710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7569_RS19715	COG0730	response to heat
K7569_RS19725	COG0134	indole-3-glycerol-phosphate synthase activity
K7569_RS19730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K7569_RS19750	COG1597	lipid kinase activity
K7569_RS19765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K7569_RS19770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K7569_RS19780	COG2111	Na H antiporter
K7569_RS19780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K7569_RS19785	COG1006	Multisubunit Na H antiporter MnhC subunit
K7569_RS19790	COG0651	ATP synthesis coupled electron transport
K7569_RS19795	COG1863	multisubunit Na H antiporter MnhE subunit
K7569_RS19800	COG2212	antiporter activity
K7569_RS19805	COG1320	monovalent cation:proton antiporter activity
K7569_RS19825	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K7569_RS19850	COG3104	oligopeptide transport
K7569_RS19855	COG3483	tryptophan 2,3-dioxygenase activity
K7569_RS19885	COG2378	regulation of single-species biofilm formation
K7569_RS19900	COG2354	Protein conserved in bacteria
K7569_RS19910	COG1368	sulfuric ester hydrolase activity
K7569_RS19915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K7569_RS19915	COG3264	Mechanosensitive ion channel
K7569_RS19930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K7569_RS19930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7569_RS19965	COG1166	arginine decarboxylase activity
K7569_RS19970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K7569_RS20000	COG2960	long-chain fatty acid transporting porin activity
K7569_RS20010	COG3209	COG3209 Rhs family protein
K7569_RS20045	COG3209	COG3209 Rhs family protein
K7569_RS20050	COG0606	chelatase, subunit chli
K7569_RS20070	COG0561	phosphatase activity
K7569_RS20075	COG3932	Exopolysaccharide synthesis, ExoD
K7569_RS20100	COG1999	signal sequence binding
K7569_RS20105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K7569_RS20110	COG1845	cytochrome c oxidase, subunit III
K7569_RS20120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K7569_RS20125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7569_RS20140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7569_RS20145	COG1104	cysteine desulfurase activity
K7569_RS20170	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K7569_RS20175	COG3409	Peptidoglycan-binding domain 1 protein
K7569_RS20175	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7569_RS20200	COG2031	fatty acid transporter
K7569_RS20205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K7569_RS20225	COG0673	inositol 2-dehydrogenase activity
K7569_RS20235	COG1501	Belongs to the glycosyl hydrolase 31 family
K7569_RS20240	COG2222	sugar isomerase
K7569_RS20245	COG1940	carbohydrate kinase activity
K7569_RS20255	COG1349	DNA-binding transcription factor activity
K7569_RS20260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K7569_RS20265	COG2814	Major facilitator Superfamily
K7569_RS20295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K7569_RS20300	COG0156	8-amino-7-oxononanoate synthase activity
K7569_RS20305	COG2267	carboxylic ester hydrolase activity
K7569_RS20310	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS20325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K7569_RS20345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7569_RS20350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7569_RS20355	COG2205	protein histidine kinase activity
K7569_RS20360	COG0745	RESPONSE REGULATOR receiver
K7569_RS20365	COG3541	Predicted nucleotidyltransferase
K7569_RS20370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K7569_RS20395	COG0714	Associated with various cellular activities
K7569_RS20410	COG0754	glutathionylspermidine amidase activity
K7569_RS20420	COG0129	dihydroxy-acid dehydratase activity
K7569_RS20430	COG1199	ATP-dependent helicase activity
K7569_RS20440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K7569_RS20460	COG3781	membrane
K7569_RS20490	COG0625	glutathione transferase activity
K7569_RS20510	COG2207	Transcriptional regulator
K7569_RS20525	COG4555	ABC transporter
K7569_RS20550	COG0543	2 iron, 2 sulfur cluster binding
K7569_RS20550	COG0633	Ferredoxin
K7569_RS20555	COG1131	(ABC) transporter
K7569_RS20560	COG0842	Transport permease protein
K7569_RS20565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K7569_RS20575	COG0084	hydrolase, TatD family'
K7569_RS20580	COG1643	Atp-dependent helicase
K7569_RS20590	COG1187	pseudouridine synthase activity
K7569_RS20605	COG0667	Aldo Keto reductase
K7569_RS20620	COG1690	Belongs to the RtcB family
K7569_RS20635	COG0840	transmembrane signaling receptor activity
K7569_RS20640	COG0656	L-ascorbic acid biosynthetic process
K7569_RS20645	COG2267	carboxylic ester hydrolase activity
K7569_RS20655	COG0045	succinate-CoA ligase (ADP-forming) activity
K7569_RS20655	COG1042	CoA-binding domain protein
K7569_RS20655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7569_RS20660	COG2239	Acts as a magnesium transporter
K7569_RS20670	COG0666	response to abiotic stimulus
K7569_RS20670	COG3177	Filamentation induced by cAMP protein fic
K7569_RS20675	COG3100	YcgL domain-containing protein
K7569_RS20685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7569_RS20690	COG1028	Short-chain dehydrogenase reductase Sdr
K7569_RS20730	COG2986	histidine ammonia-lyase
K7569_RS20740	COG0463	Glycosyl transferase, family 2
K7569_RS20755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7569_RS20760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7569_RS20775	COG1294	oxidase, subunit
K7569_RS20780	COG1271	oxidase subunit
K7569_RS20800	COG1595	DNA-templated transcription, initiation
K7569_RS20830	COG0408	coproporphyrinogen oxidase activity
K7569_RS20835	COG2323	membrane
K7569_RS20850	COG0589	response to stress
K7569_RS20865	COG0210	DNA helicase
K7569_RS20875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7569_RS20880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K7569_RS20885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K7569_RS20890	COG1819	glycosyl
K7569_RS20905	COG0251	oxidation-reduction process
K7569_RS20950	COG0463	Glycosyl transferase, family 2
K7569_RS20960	COG1475	DNA binding
K7569_RS20965	COG1192	Involved in chromosome partitioning
K7569_RS20970	COG0357	Ribosomal RNA small subunit methyltransferase G
K7569_RS20975	COG2091	lysine biosynthetic process via aminoadipic acid
K7569_RS21015	COG1943	Transposase
K7569_RS21020	COG1971	Probably functions as a manganese efflux pump
K7569_RS21035	COG2911	Protein conserved in bacteria
K7569_RS21040	COG0729	surface antigen
K7569_RS21050	COG0752	glycyl-tRNA synthetase alpha subunit
K7569_RS21055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K7569_RS21060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7569_RS21060	COG0519	Catalyzes the synthesis of GMP from XMP
K7569_RS21070	COG0805	protein transport
K7569_RS21080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K7569_RS21090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K7569_RS21100	COG0840	transmembrane signaling receptor activity
K7569_RS21160	COG3135	benzoate transporter
K7569_RS21175	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K7569_RS21180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K7569_RS21190	COG3706	GGDEF domain
K7569_RS21220	COG0302	gtp cyclohydrolase
K7569_RS21245	COG1289	transmembrane transporter activity
K7569_RS21260	COG1074	ATP-dependent DNA helicase activity
K7569_RS21265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K7569_RS21270	COG1127	ABC transporter
K7569_RS21275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K7569_RS21280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K7569_RS21300	COG0386	Belongs to the glutathione peroxidase family
K7569_RS21310	COG1322	Protein conserved in bacteria
K7569_RS21325	COG0583	DNA-binding transcription factor activity
K7569_RS21335	COG0531	amino acid
K7569_RS21345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K7569_RS21350	COG0861	Integral membrane protein TerC family
K7569_RS21360	COG0584	glycerophosphoryl diester phosphodiesterase
K7569_RS21375	COG0706	membrane insertase activity
K7569_RS21380	COG0594	ribonuclease P activity
K7569_RS21385	COG0230	Belongs to the bacterial ribosomal protein bL34 family