locus-tag	class	description
K7573_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K7573_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K7573_RS00020	COG0187	DNA topoisomerase II activity
K7573_RS00025	COG1266	CAAX protease self-immunity
K7573_RS00030	COG0501	Belongs to the peptidase M48B family
K7573_RS00100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K7573_RS00110	COG4772	TonB-dependent receptor
K7573_RS00145	COG0800	Aldolase
K7573_RS00165	COG3186	Phenylalanine-4-hydroxylase
K7573_RS00170	COG1522	sequence-specific DNA binding
K7573_RS00175	COG1752	Esterase of the alpha-beta hydrolase superfamily
K7573_RS00205	COG1119	ATPase activity
K7573_RS00220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K7573_RS00225	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K7573_RS00245	COG0210	DNA helicase
K7573_RS00255	COG3132	Protein of unknown function, DUF480
K7573_RS00260	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K7573_RS00265	COG0284	orotidine-5'-phosphate decarboxylase activity
K7573_RS00275	COG2937	Belongs to the GPAT DAPAT family
K7573_RS00285	COG0037	tRNA processing
K7573_RS00290	COG2974	May be involved in recombination
K7573_RS00305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7573_RS00305	COG2205	protein histidine kinase activity
K7573_RS00310	COG0493	'glutamate synthase
K7573_RS00315	COG0067	glutamate synthase
K7573_RS00315	COG0069	glutamate synthase activity
K7573_RS00315	COG0070	glutamate synthase
K7573_RS00335	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS00350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7573_RS00375	COG1205	dead DEAH box helicase
K7573_RS00375	COG1111	helicase
K7573_RS00410	COG0714	Associated with various cellular activities
K7573_RS00430	COG0312	modulator of DNA gyrase
K7573_RS00440	COG3550	peptidyl-serine autophosphorylation
K7573_RS00460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K7573_RS00480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7573_RS00505	COG1881	PFAM PEBP family protein
K7573_RS00520	COG1968	undecaprenyl-diphosphatase activity
K7573_RS00525	COG0174	glutamine synthetase
K7573_RS00530	COG0347	Belongs to the P(II) protein family
K7573_RS00535	COG0004	ammonium transporteR
K7573_RS00550	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K7573_RS00565	COG3852	Histidine kinase
K7573_RS00570	COG2204	response regulator
K7573_RS00575	COG2032	superoxide dismutase activity
K7573_RS00580	COG2032	superoxide dismutase activity
K7573_RS00595	COG0183	Belongs to the thiolase family
K7573_RS00630	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K7573_RS00635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K7573_RS00655	COG0798	PFAM Bile acid sodium symporter
K7573_RS00675	COG0431	NADPH-dependent FMN reductase
K7573_RS00710	COG2837	iron assimilation
K7573_RS00750	COG2197	response regulator
K7573_RS00755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7573_RS00755	COG2205	protein histidine kinase activity
K7573_RS00760	COG3474	cytochrome
K7573_RS00770	COG1960	acyl-CoA dehydrogenase activity
K7573_RS00775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K7573_RS00785	COG0612	Peptidase, M16
K7573_RS00795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7573_RS00800	COG0596	Alpha beta hydrolase
K7573_RS00810	COG0318	PFAM AMP-dependent synthetase and ligase
K7573_RS00815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K7573_RS00825	COG1181	Belongs to the D-alanine--D-alanine ligase family
K7573_RS00835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K7573_RS00850	COG1215	transferase activity, transferring glycosyl groups
K7573_RS00855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K7573_RS00885	COG0339	signal peptide processing
K7573_RS00900	COG0681	Belongs to the peptidase S26 family
K7573_RS00905	COG2814	Major facilitator Superfamily
K7573_RS00910	COG2801	Transposase and inactivated derivatives
K7573_RS00910	COG3415	Transposase
K7573_RS00915	COG0583	DNA-binding transcription factor activity
K7573_RS00920	COG0583	DNA-binding transcription factor activity
K7573_RS00925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K7573_RS00930	COG2224	Isocitrate lyase
K7573_RS00935	COG3706	GGDEF domain
K7573_RS00960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7573_RS00965	COG1960	acyl-CoA dehydrogenase activity
K7573_RS00985	COG0697	spore germination
K7573_RS00995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K7573_RS01005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7573_RS01015	COG1280	lysine exporter protein (LysE YggA)
K7573_RS01020	COG1607	acyl-coa hydrolase
K7573_RS01030	COG1902	pentaerythritol trinitrate reductase activity
K7573_RS01045	COG1335	isochorismatase
K7573_RS01050	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K7573_RS01060	COG1051	belongs to the nudix hydrolase family
K7573_RS01060	COG1056	cytidyltransferase-related domain
K7573_RS01065	COG1752	Esterase of the alpha-beta hydrolase superfamily
K7573_RS01080	COG1396	sequence-specific DNA binding
K7573_RS01080	COG3800	Transcriptional regulator
K7573_RS01090	COG1960	acyl-CoA dehydrogenase activity
K7573_RS01095	COG1024	Enoyl-CoA hydratase
K7573_RS01100	COG1024	Enoyl-CoA hydratase
K7573_RS01110	COG1764	response to oxidative stress
K7573_RS01135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K7573_RS01155	COG3228	Belongs to the MtfA family
K7573_RS01165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K7573_RS01165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K7573_RS01170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K7573_RS01185	COG3657	addiction module killer protein
K7573_RS01230	COG3237	CsbD-like
K7573_RS01240	COG0180	Tryptophanyl-tRNA synthetase
K7573_RS01265	COG0477	Major facilitator Superfamily
K7573_RS01270	COG0697	spore germination
K7573_RS01280	COG4206	TonB-dependent receptor
K7573_RS01285	COG1136	(ABC) transporter
K7573_RS01285	COG0577	efflux transmembrane transporter activity
K7573_RS01295	COG1136	(ABC) transporter
K7573_RS01315	COG4585	Histidine kinase
K7573_RS01320	COG2197	response regulator
K7573_RS01330	COG0753	catalase activity
K7573_RS01335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K7573_RS01350	COG0628	permease
K7573_RS01370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7573_RS01385	COG5507	3-demethylubiquinone-9 3-methyltransferase
K7573_RS01400	COG2197	response regulator
K7573_RS01415	COG2814	Major facilitator Superfamily
K7573_RS01420	COG0583	DNA-binding transcription factor activity
K7573_RS01425	COG4807	Protein conserved in bacteria
K7573_RS01435	COG4221	oxidoreductase activity
K7573_RS01445	COG0018	arginyl-trna synthetase
K7573_RS01450	COG2003	Belongs to the UPF0758 family
K7573_RS01455	COG2197	response regulator
K7573_RS01460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K7573_RS01465	COG0756	dUTP diphosphatase activity
K7573_RS01480	COG2205	protein histidine kinase activity
K7573_RS01490	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K7573_RS01495	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K7573_RS01510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K7573_RS01515	COG0708	Exodeoxyribonuclease III
K7573_RS01520	COG2223	nitrite transmembrane transporter activity
K7573_RS01540	COG0739	heme binding
K7573_RS01545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K7573_RS01605	COG2234	aminopeptidase activity
K7573_RS01615	COG4942	peptidase
K7573_RS01620	COG0793	Belongs to the peptidase S41A family
K7573_RS01655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K7573_RS01700	COG0109	protoheme IX farnesyltransferase activity
K7573_RS01720	COG0358	DNA primase activity
K7573_RS01725	COG1295	ribonuclease BN
K7573_RS01740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K7573_RS01750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K7573_RS01755	COG0668	transmembrane transport
K7573_RS01770	COG2133	pyrroloquinoline quinone binding
K7573_RS01775	COG4682	membrane
K7573_RS01785	COG0531	amino acid
K7573_RS01795	COG1737	Transcriptional regulator
K7573_RS01800	COG4948	Mandelate Racemase Muconate Lactonizing
K7573_RS01820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7573_RS01850	COG5383	Protein conserved in bacteria
K7573_RS01860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K7573_RS01865	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K7573_RS01895	COG0778	Nitroreductase
K7573_RS01900	COG2353	YceI-like domain
K7573_RS01915	COG2375	cellular response to nickel ion
K7573_RS01935	COG1401	restriction endodeoxyribonuclease activity
K7573_RS02010	COG2267	carboxylic ester hydrolase activity
K7573_RS02075	COG0488	(ABC) transporter
K7573_RS02080	COG0583	DNA-binding transcription factor activity
K7573_RS02090	COG2814	Major facilitator Superfamily
K7573_RS02100	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K7573_RS02105	COG1113	amino acid transport
K7573_RS02110	COG0741	lytic transglycosylase activity
K7573_RS02135	COG2764	glyoxalase bleomycin resistance protein dioxygenase
K7573_RS02145	COG5507	3-demethylubiquinone-9 3-methyltransferase
K7573_RS02150	COG4941	Belongs to the sigma-70 factor family
K7573_RS02180	COG3275	phosphorelay sensor kinase activity
K7573_RS02185	COG3279	Response regulator of the LytR AlgR family
K7573_RS02205	COG1309	transcriptional regulator
K7573_RS02220	COG3590	peptidase
K7573_RS02225	COG5001	Diguanylate cyclase
K7573_RS02230	COG0583	DNA-binding transcription factor activity
K7573_RS02240	COG3384	dioxygenase
K7573_RS02245	COG0025	NhaP-type Na H and K H
K7573_RS02270	COG1360	Flagellar Motor Protein
K7573_RS02300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7573_RS02315	COG5002	protein histidine kinase activity
K7573_RS02330	COG2813	Specifically methylates the guanine in position
K7573_RS02335	COG1187	pseudouridine synthase activity
K7573_RS02340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7573_RS02350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K7573_RS02355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K7573_RS02370	COG0583	DNA-binding transcription factor activity
K7573_RS02375	COG2226	methyltransferase
K7573_RS02400	COG1956	GAF domain-containing protein
K7573_RS02405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K7573_RS02410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7573_RS02415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7573_RS02420	COG0785	Cytochrome C biogenesis protein
K7573_RS02420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7573_RS02425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7573_RS02430	COG0745	RESPONSE REGULATOR receiver
K7573_RS02435	COG2205	protein histidine kinase activity
K7573_RS02440	COG2205	protein histidine kinase activity
K7573_RS02445	COG0745	RESPONSE REGULATOR receiver
K7573_RS02450	COG0367	asparagine synthase
K7573_RS02460	COG0720	synthase
K7573_RS02475	COG0513	Belongs to the DEAD box helicase family
K7573_RS02485	COG0625	glutathione transferase activity
K7573_RS02525	COG0626	cystathionine gamma-synthase activity
K7573_RS02560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K7573_RS02585	COG0546	phosphoglycolate phosphatase activity
K7573_RS02585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K7573_RS02615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7573_RS02620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K7573_RS02680	COG1127	ABC transporter
K7573_RS02685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K7573_RS02700	COG0442	prolyl-tRNA aminoacylation
K7573_RS02710	COG1183	phosphatidylcholine synthase activity
K7573_RS02720	COG0456	acetyltransferase
K7573_RS02730	COG0525	valine-tRNA ligase activity
K7573_RS02740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K7573_RS02750	COG0795	lipopolysaccharide-transporting ATPase activity
K7573_RS02765	COG4974	Belongs to the 'phage' integrase family
K7573_RS02770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K7573_RS02785	COG0047	phosphoribosylformylglycinamidine synthase activity
K7573_RS02785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K7573_RS02790	COG5295	Hep Hag repeat protein
K7573_RS02795	COG1404	Belongs to the peptidase S8 family
K7573_RS02800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K7573_RS02805	COG1459	type II secretion system
K7573_RS02810	COG2165	general secretion pathway protein
K7573_RS02815	COG4970	Tfp pilus assembly protein FimT
K7573_RS02820	COG2165	general secretion pathway protein
K7573_RS02825	COG4795	General secretion pathway protein
K7573_RS02830	COG3156	type II secretion system protein K
K7573_RS02835	COG3166	PFAM Fimbrial assembly family protein
K7573_RS02850	COG1450	Type ii and iii secretion system protein
K7573_RS02865	COG0463	Glycosyl transferase, family 2
K7573_RS02880	COG3539	Fimbrial protein
K7573_RS02900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K7573_RS02910	COG1215	transferase activity, transferring glycosyl groups
K7573_RS02925	COG2252	PERMEase
K7573_RS02930	COG0488	(ABC) transporter
K7573_RS02940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K7573_RS02960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K7573_RS02965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K7573_RS02965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K7573_RS03000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K7573_RS03005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K7573_RS03015	COG3121	Chaperone
K7573_RS03030	COG3188	usher protein
K7573_RS03040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K7573_RS03040	COG2755	lipolytic protein G-D-S-L family
K7573_RS03045	COG0277	FAD linked oxidase domain protein
K7573_RS03050	COG1988	membrane-bound metal-dependent
K7573_RS03085	COG2001	Belongs to the MraZ family
K7573_RS03090	COG0275	rRNA processing
K7573_RS03095	COG3116	cell division
K7573_RS03105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K7573_RS03110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K7573_RS03130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K7573_RS03135	COG1181	Belongs to the D-alanine--D-alanine ligase family
K7573_RS03140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K7573_RS03150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K7573_RS03155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K7573_RS03165	COG0739	heme binding
K7573_RS03170	COG0653	protein targeting
K7573_RS03190	COG0494	nUDIX hydrolase
K7573_RS03200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K7573_RS03210	COG3275	phosphorelay sensor kinase activity
K7573_RS03235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K7573_RS03240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K7573_RS03250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K7573_RS03255	COG1607	acyl-coa hydrolase
K7573_RS03260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K7573_RS03290	COG4106	trans-aconitate 2-methyltransferase activity
K7573_RS03295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K7573_RS03315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7573_RS03320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K7573_RS03325	COG0667	Aldo Keto reductase
K7573_RS03335	COG4771	TonB-dependent receptor
K7573_RS03350	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K7573_RS03355	COG4181	ATPase activity
K7573_RS03370	COG0642	Histidine kinase
K7573_RS03380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K7573_RS03385	COG0861	Integral membrane protein TerC family
K7573_RS03390	COG2814	Major facilitator Superfamily
K7573_RS03395	COG1704	LemA family
K7573_RS03410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K7573_RS03415	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K7573_RS03425	COG3738	Protein conserved in bacteria
K7573_RS03430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K7573_RS03435	COG2967	ApaG domain
K7573_RS03440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K7573_RS03445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K7573_RS03450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K7573_RS03455	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K7573_RS03465	COG2096	Adenosyltransferase
K7573_RS03475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7573_RS03480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7573_RS03485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K7573_RS03490	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K7573_RS03510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K7573_RS03520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K7573_RS03535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7573_RS03540	COG0583	DNA-binding transcription factor activity
K7573_RS03545	COG3634	alkyl hydroperoxide reductase activity
K7573_RS03585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K7573_RS03585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K7573_RS03600	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K7573_RS03625	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K7573_RS03640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K7573_RS03645	COG1404	Belongs to the peptidase S8 family
K7573_RS03665	COG1295	ribonuclease BN
K7573_RS03670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7573_RS03685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K7573_RS03690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K7573_RS03705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K7573_RS03715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K7573_RS03720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K7573_RS03725	COG0193	aminoacyl-tRNA hydrolase activity
K7573_RS03730	COG0012	GTP binding
K7573_RS03740	COG2197	response regulator
K7573_RS03745	COG0784	Response regulator, receiver
K7573_RS03745	COG2205	protein histidine kinase activity
K7573_RS03750	COG2199	diguanylate cyclase activity
K7573_RS03750	COG2200	EAL domain
K7573_RS03750	COG2203	Gaf domain
K7573_RS03755	COG0784	Response regulator, receiver
K7573_RS03755	COG2205	protein histidine kinase activity
K7573_RS03760	COG4206	TonB-dependent receptor
K7573_RS03765	COG4242	Belongs to the peptidase S51 family
K7573_RS03790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K7573_RS03805	COG0250	Participates in transcription elongation, termination and antitermination
K7573_RS03810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K7573_RS03815	COG0081	regulation of translation
K7573_RS03820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K7573_RS03825	COG0222	ribosome binding
K7573_RS03830	COG0085	RNA polymerase activity
K7573_RS03835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K7573_RS03840	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K7573_RS03845	COG0049	tRNA binding
K7573_RS03850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K7573_RS03855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K7573_RS03860	COG0051	transcription antitermination factor activity, RNA binding
K7573_RS03865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K7573_RS03870	COG0088	Forms part of the polypeptide exit tunnel
K7573_RS03875	COG0089	rRNA binding
K7573_RS03880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K7573_RS03885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K7573_RS03890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K7573_RS03895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K7573_RS03900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K7573_RS03905	COG0255	Belongs to the universal ribosomal protein uL29 family
K7573_RS03910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K7573_RS03915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K7573_RS03920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K7573_RS03925	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K7573_RS03930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K7573_RS03935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K7573_RS03940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K7573_RS03945	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K7573_RS03950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K7573_RS03955	COG1841	ribosomal large subunit assembly
K7573_RS03960	COG0200	Binds to the 23S rRNA
K7573_RS03965	COG0201	protein transport
K7573_RS03970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K7573_RS03975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K7573_RS03980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K7573_RS03985	COG0202	RNA polymerase activity
K7573_RS03990	COG0203	ribosomal protein L17
K7573_RS04005	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K7573_RS04015	COG0154	amidase activity
K7573_RS04030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K7573_RS04035	COG0039	L-malate dehydrogenase activity
K7573_RS04040	COG0564	pseudouridine synthase activity
K7573_RS04050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7573_RS04065	COG0625	glutathione transferase activity
K7573_RS04075	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7573_RS04075	COG1902	pentaerythritol trinitrate reductase activity
K7573_RS04080	COG2364	Membrane
K7573_RS04085	COG0604	alcohol dehydrogenase
K7573_RS04100	COG1187	pseudouridine synthase activity
K7573_RS04120	COG1063	alcohol dehydrogenase
K7573_RS04130	COG0406	alpha-ribazole phosphatase activity
K7573_RS04135	COG0285	dihydrofolate synthase activity
K7573_RS04155	COG2833	Protein of unknown function (DUF455)
K7573_RS04165	COG3291	Pkd domain containing protein
K7573_RS04170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K7573_RS04180	COG0438	transferase activity, transferring glycosyl groups
K7573_RS04195	COG0248	Ppx GppA phosphatase
K7573_RS04200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K7573_RS04215	COG4783	chaperone-mediated protein folding
K7573_RS04230	COG0473	3-isopropylmalate dehydrogenase activity
K7573_RS04300	COG0544	peptidyl-prolyl cis-trans isomerase activity
K7573_RS04305	COG0740	serine-type endopeptidase activity
K7573_RS04310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K7573_RS04350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K7573_RS04355	COG3942	CHAP domain
K7573_RS04355	COG1388	LysM domain
K7573_RS04360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7573_RS04370	COG0328	RNA-DNA hybrid ribonuclease activity
K7573_RS04375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K7573_RS04380	COG0631	protein serine/threonine phosphatase activity
K7573_RS04400	COG0859	PFAM glycosyl transferase family 9
K7573_RS04405	COG3642	lipopolysaccharide core region biosynthetic process
K7573_RS04410	COG1234	tRNA 3'-trailer cleavage
K7573_RS04425	COG2076	Multidrug Resistance protein
K7573_RS04465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K7573_RS04475	COG0537	adenosine 5'-monophosphoramidase activity
K7573_RS04495	COG0714	Associated with various cellular activities
K7573_RS04510	COG1399	metal-binding, possibly nucleic acid-binding protein
K7573_RS04515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K7573_RS04520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7573_RS04530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K7573_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS04545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7573_RS04550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K7573_RS04555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K7573_RS04560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K7573_RS04715	COG4774	siderophore transport
K7573_RS04730	COG2223	nitrite transmembrane transporter activity
K7573_RS04745	COG2226	methyltransferase
K7573_RS04755	COG0583	DNA-binding transcription factor activity
K7573_RS04760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7573_RS04765	COG0697	spore germination
K7573_RS04775	COG0477	Major facilitator Superfamily
K7573_RS04810	COG0583	DNA-binding transcription factor activity
K7573_RS04820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K7573_RS04835	COG0667	Aldo Keto reductase
K7573_RS04860	COG2818	Glycosylase
K7573_RS04865	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K7573_RS04870	COG1678	Uncharacterized ACR, COG1678
K7573_RS04875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K7573_RS04880	COG0540	Belongs to the ATCase OTCase family
K7573_RS04900	COG2239	Acts as a magnesium transporter
K7573_RS04905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K7573_RS04920	COG1660	Displays ATPase and GTPase activities
K7573_RS04925	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K7573_RS04930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K7573_RS04935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K7573_RS04945	COG1137	ATPase activity
K7573_RS04960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K7573_RS04975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K7573_RS04995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K7573_RS05015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K7573_RS05025	COG0628	permease
K7573_RS05035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K7573_RS05045	COG2261	transglycosylase associated protein
K7573_RS05055	COG1555	photosystem II stabilization
K7573_RS05075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K7573_RS05080	COG1477	protein flavinylation
K7573_RS05100	COG4771	TonB-dependent receptor
K7573_RS05110	COG3128	pkhd-type hydroxylase
K7573_RS05120	COG4774	siderophore transport
K7573_RS05130	COG2146	nitrite reductase [NAD(P)H] activity
K7573_RS05145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K7573_RS05150	COG0719	Fe-S assembly protein
K7573_RS05155	COG0396	ATPase activity
K7573_RS05165	COG0719	Fe-S assembly protein
K7573_RS05170	COG1959	2 iron, 2 sulfur cluster binding
K7573_RS05180	COG0693	protein deglycase activity
K7573_RS05205	COG1764	response to oxidative stress
K7573_RS05210	COG0384	phenazine biosynthesis protein PhzF
K7573_RS05215	COG0384	phenazine biosynthesis protein PhzF
K7573_RS05220	COG0527	aspartate kinase activity
K7573_RS05245	COG0142	geranyltranstransferase activity
K7573_RS05250	COG0366	Alpha amylase catalytic
K7573_RS05260	COG1082	Xylose isomerase domain protein TIM barrel
K7573_RS05270	COG2190	(PTS) system
K7573_RS05270	COG2211	Major facilitator Superfamily
K7573_RS05275	COG1874	Beta-galactosidase
K7573_RS05275	COG0366	Alpha amylase catalytic
K7573_RS05305	COG1131	(ABC) transporter
K7573_RS05315	COG2423	ornithine cyclodeaminase activity
K7573_RS05350	COG2423	ornithine cyclodeaminase activity
K7573_RS05355	COG0629	single-stranded DNA binding
K7573_RS05385	COG2010	Cytochrome c
K7573_RS05395	COG0673	inositol 2-dehydrogenase activity
K7573_RS05400	COG2211	Major facilitator Superfamily
K7573_RS05410	COG1609	Transcriptional regulator
K7573_RS05450	COG0640	Transcriptional regulator
K7573_RS05465	COG3655	Transcriptional regulator
K7573_RS05470	COG1253	flavin adenine dinucleotide binding
K7573_RS05475	COG1408	metallophosphoesterase
K7573_RS05480	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K7573_RS05500	COG2259	Doxx family
K7573_RS05530	COG0477	Major facilitator Superfamily
K7573_RS05545	COG1802	Transcriptional regulator
K7573_RS05580	COG3052	prosthetic group binding
K7573_RS05595	COG0579	oxidoreductase
K7573_RS05620	COG3104	oligopeptide transport
K7573_RS05635	COG1297	OPT oligopeptide transporter protein
K7573_RS05640	COG0823	Involved in the tonB-independent uptake of proteins
K7573_RS05640	COG1506	peptidase
K7573_RS05655	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K7573_RS05660	COG2894	cell division
K7573_RS05675	COG4585	Histidine kinase
K7573_RS05680	COG2197	response regulator
K7573_RS05720	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K7573_RS05730	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K7573_RS05740	COG1595	DNA-templated transcription, initiation
K7573_RS05750	COG1946	Acyl-CoA thioesterase
K7573_RS05770	COG0824	Thioesterase
K7573_RS05775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K7573_RS05780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K7573_RS05785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K7573_RS05790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K7573_RS05795	COG0268	Binds directly to 16S ribosomal RNA
K7573_RS05800	COG0728	peptidoglycan biosynthetic process
K7573_RS05805	COG0196	riboflavin kinase activity
K7573_RS05810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K7573_RS05820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K7573_RS05845	COG4206	TonB-dependent receptor
K7573_RS05865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K7573_RS05875	COG3209	COG3209 Rhs family protein
K7573_RS05900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K7573_RS05905	COG1845	cytochrome c oxidase, subunit III
K7573_RS05910	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K7573_RS05925	COG0326	Molecular chaperone. Has ATPase activity
K7573_RS05945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K7573_RS05960	COG0228	four-way junction DNA binding
K7573_RS05965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K7573_RS05970	COG0336	Belongs to the RNA methyltransferase TrmD family
K7573_RS05975	COG0335	large ribosomal subunit rRNA binding
K7573_RS05995	COG0534	Mate efflux family protein
K7573_RS06020	COG0753	catalase activity
K7573_RS06040	COG2831	hemolysin activation secretion protein
K7573_RS06090	COG0840	transmembrane signaling receptor activity
K7573_RS06110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS06130	COG0024	Methionine aminopeptidase
K7573_RS06155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K7573_RS06180	COG1647	Serine aminopeptidase, S33
K7573_RS06205	COG2814	Major facilitator Superfamily
K7573_RS06210	COG2801	Transposase and inactivated derivatives
K7573_RS06210	COG3415	Transposase
K7573_RS06215	COG3706	GGDEF domain
K7573_RS06240	COG0588	phosphoglycerate mutase activity
K7573_RS06245	COG3590	peptidase
K7573_RS06255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K7573_RS06265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K7573_RS06270	COG0745	RESPONSE REGULATOR receiver
K7573_RS06275	COG2205	protein histidine kinase activity
K7573_RS06280	COG4452	Inner membrane protein CreD
K7573_RS06295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K7573_RS06300	COG0735	belongs to the Fur family
K7573_RS06340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7573_RS06380	COG5002	protein histidine kinase activity
K7573_RS06380	COG5001	Diguanylate cyclase
K7573_RS06390	COG1187	pseudouridine synthase activity
K7573_RS06400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K7573_RS06425	COG1132	(ABC) transporter
K7573_RS06475	COG1695	Transcriptional regulator
K7573_RS06495	COG1981	membrane
K7573_RS06500	COG0825	malonyl-CoA metabolic process
K7573_RS06525	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K7573_RS06535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K7573_RS06540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7573_RS06545	COG0750	zinc metalloprotease
K7573_RS06550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K7573_RS06555	COG0575	Belongs to the CDS family
K7573_RS06560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K7573_RS06565	COG0233	cytoplasmic translational termination
K7573_RS06570	COG0528	UMP kinase activity
K7573_RS06580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K7573_RS06585	COG0052	Belongs to the universal ribosomal protein uS2 family
K7573_RS06605	COG3188	usher protein
K7573_RS06625	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K7573_RS06640	COG1393	Belongs to the ArsC family
K7573_RS06645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7573_RS06650	COG0367	asparagine synthase
K7573_RS06655	COG0475	glutathione-regulated potassium exporter activity
K7573_RS06690	COG1566	PFAM secretion protein HlyD family protein
K7573_RS06695	COG2814	Major facilitator Superfamily
K7573_RS06710	COG0583	DNA-binding transcription factor activity
K7573_RS06730	COG0557	exoribonuclease II activity
K7573_RS06740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7573_RS06745	COG1538	Outer membrane efflux protein
K7573_RS06750	COG0577	efflux transmembrane transporter activity
K7573_RS06750	COG1136	(ABC) transporter
K7573_RS06755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS06775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K7573_RS06780	COG2259	Doxx family
K7573_RS06790	COG3220	belongs to the UPF0276 family
K7573_RS06800	COG0704	Plays a role in the regulation of phosphate uptake
K7573_RS06810	COG0581	inorganic phosphate transmembrane transporter activity
K7573_RS06815	COG0573	inorganic phosphate transmembrane transporter activity
K7573_RS06820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K7573_RS06825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K7573_RS06835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K7573_RS06845	COG1024	Enoyl-CoA hydratase
K7573_RS06855	COG0494	nUDIX hydrolase
K7573_RS06875	COG0116	Belongs to the methyltransferase superfamily
K7573_RS06875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K7573_RS06895	COG2733	membrane
K7573_RS06905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K7573_RS06910	COG1012	belongs to the aldehyde dehydrogenase family
K7573_RS06920	COG0477	Major facilitator Superfamily
K7573_RS06925	COG2703	oxygen carrier activity
K7573_RS06945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7573_RS06950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K7573_RS06955	COG0174	glutamine synthetase
K7573_RS06965	COG2072	flavoprotein involved in K transport
K7573_RS06970	COG3842	ATPase activity
K7573_RS06975	COG1176	ABC-type spermidine putrescine transport system, permease component I
K7573_RS06980	COG1177	transmembrane transport
K7573_RS06985	COG1012	belongs to the aldehyde dehydrogenase family
K7573_RS07000	COG4535	Mg2 and Co2 transporter CorC
K7573_RS07020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K7573_RS07025	COG1702	phosphate starvation-inducible protein PhoH
K7573_RS07030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS07035	COG1131	(ABC) transporter
K7573_RS07040	COG0842	Transport permease protein
K7573_RS07045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7573_RS07060	COG0741	lytic transglycosylase activity
K7573_RS07065	COG0723	plastoquinol--plastocyanin reductase activity
K7573_RS07070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K7573_RS07075	COG2857	Cytochrome c1
K7573_RS07080	COG0625	glutathione transferase activity
K7573_RS07085	COG2969	positive regulation of protein catabolic process
K7573_RS07120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7573_RS07130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K7573_RS07145	COG1611	Belongs to the LOG family
K7573_RS07185	COG4970	Tfp pilus assembly protein FimT
K7573_RS07190	COG0556	nucleotide-excision repair
K7573_RS07230	COG3713	MltA-interacting MipA family protein
K7573_RS07250	COG0811	peptide transport
K7573_RS07265	COG1663	tetraacyldisaccharide 4'-kinase activity
K7573_RS07270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K7573_RS07275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7573_RS07285	COG0322	excinuclease ABC activity
K7573_RS07320	COG0577	efflux transmembrane transporter activity
K7573_RS07320	COG1136	(ABC) transporter
K7573_RS07410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K7573_RS07435	COG0583	DNA-binding transcription factor activity
K7573_RS07455	COG1917	Cupin 2, conserved barrel domain protein
K7573_RS07455	COG4977	sequence-specific DNA binding
K7573_RS07460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7573_RS07480	COG0348	domain, Protein
K7573_RS07495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K7573_RS07510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K7573_RS07515	COG0069	glutamate synthase activity
K7573_RS07540	COG1054	Belongs to the UPF0176 family
K7573_RS07545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7573_RS07560	COG1253	flavin adenine dinucleotide binding
K7573_RS07580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7573_RS07595	COG0504	CTP synthase activity
K7573_RS07600	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K7573_RS07615	COG0148	phosphopyruvate hydratase activity
K7573_RS07620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K7573_RS07625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K7573_RS07630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K7573_RS07640	COG2840	Smr protein MutS2
K7573_RS07645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K7573_RS07650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K7573_RS07675	COG1534	Rna-binding protein
K7573_RS07680	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K7573_RS07685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K7573_RS07695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K7573_RS07700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K7573_RS07705	COG1923	regulation of RNA biosynthetic process
K7573_RS07710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K7573_RS07715	COG1546	Belongs to the CinA family
K7573_RS07720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K7573_RS07725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K7573_RS07730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K7573_RS07735	COG2137	regulation of response to DNA damage stimulus
K7573_RS07740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K7573_RS07745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K7573_RS07795	COG3540	Alkaline phosphatase
K7573_RS07810	COG3258	Cytochrome c
K7573_RS07825	COG2223	nitrite transmembrane transporter activity
K7573_RS07840	COG1741	Belongs to the pirin family
K7573_RS07845	COG0583	DNA-binding transcription factor activity
K7573_RS07880	COG0352	thiamine-phosphate diphosphorylase activity
K7573_RS07880	COG0351	phosphomethylpyrimidine kinase
K7573_RS07895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K7573_RS07900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K7573_RS07910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K7573_RS07920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K7573_RS07925	COG0477	Major facilitator Superfamily
K7573_RS07935	COG0617	tRNA 3'-terminal CCA addition
K7573_RS07940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K7573_RS07945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K7573_RS07950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K7573_RS07960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K7573_RS07965	COG0166	Belongs to the GPI family
K7573_RS07970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K7573_RS07980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K7573_RS07985	COG0671	phosphoesterase, PA-phosphatase related
K7573_RS07995	COG0800	Aldolase
K7573_RS08000	COG0129	dihydroxy-acid dehydratase activity
K7573_RS08010	COG0837	glucose binding
K7573_RS08035	COG2009	succinate dehydrogenase
K7573_RS08040	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K7573_RS08045	COG1053	succinate dehydrogenase
K7573_RS08065	COG4591	ABC-type transport system involved in lipoprotein release permease component
K7573_RS08080	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K7573_RS08090	COG0552	protein localization to endoplasmic reticulum
K7573_RS08105	COG0742	ribosomal rna small subunit methyltransferase
K7573_RS08110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K7573_RS08120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K7573_RS08125	COG0405	Gamma-glutamyltransferase
K7573_RS08130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7573_RS08150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K7573_RS08170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K7573_RS08185	COG0415	Belongs to the DNA photolyase family
K7573_RS08190	COG2885	chlorophyll binding
K7573_RS08195	COG0583	DNA-binding transcription factor activity
K7573_RS08295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K7573_RS08305	COG2914	Belongs to the UPF0125 (RnfH) family
K7573_RS08310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7573_RS08315	COG0735	belongs to the Fur family
K7573_RS08325	COG0583	DNA-binding transcription factor activity
K7573_RS08330	COG0497	DNA recombination
K7573_RS08335	COG1420	regulation of RNA biosynthetic process
K7573_RS08340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K7573_RS08345	COG0443	Heat shock 70 kDa protein
K7573_RS08350	COG0484	heat shock protein binding
K7573_RS08355	COG2207	Transcriptional regulator
K7573_RS08360	COG2223	nitrite transmembrane transporter activity
K7573_RS08365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K7573_RS08370	COG0287	Prephenate dehydrogenase
K7573_RS08370	COG1605	Chorismate mutase
K7573_RS08380	COG1132	(ABC) transporter
K7573_RS08410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K7573_RS08415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K7573_RS08420	COG0343	queuine tRNA-ribosyltransferase activity
K7573_RS08425	COG1862	Preprotein translocase
K7573_RS08435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7573_RS08440	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K7573_RS08450	COG2081	HI0933 family
K7573_RS08455	COG4681	YaeQ
K7573_RS08475	COG0625	glutathione transferase activity
K7573_RS08480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K7573_RS08485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K7573_RS08490	COG0513	Belongs to the DEAD box helicase family
K7573_RS08500	COG0583	DNA-binding transcription factor activity
K7573_RS08505	COG0488	(ABC) transporter
K7573_RS08530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7573_RS08545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7573_RS08550	COG2957	Belongs to the agmatine deiminase family
K7573_RS08560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K7573_RS08565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K7573_RS08575	COG0776	regulation of translation
K7573_RS08585	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K7573_RS08590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K7573_RS08600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K7573_RS08605	COG0183	Belongs to the thiolase family
K7573_RS08610	COG1024	Enoyl-CoA hydratase
K7573_RS08610	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7573_RS08620	COG0105	UTP biosynthetic process
K7573_RS08625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K7573_RS08630	COG0457	Tetratricopeptide repeat
K7573_RS08630	COG0859	PFAM glycosyl transferase family 9
K7573_RS08635	COG1426	Protein conserved in bacteria
K7573_RS08635	COG1426	Protein conserved in bacteria
K7573_RS08645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7573_RS08650	COG1160	GTP binding
K7573_RS08670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K7573_RS08675	COG0475	glutathione-regulated potassium exporter activity
K7573_RS08675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K7573_RS08690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7573_RS08690	COG0519	Catalyzes the synthesis of GMP from XMP
K7573_RS08695	COG0582	viral genome integration into host DNA
K7573_RS08825	COG0583	DNA-binding transcription factor activity
K7573_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS08890	COG0640	Transcriptional regulator
K7573_RS08905	COG4716	Myosin-crossreactive antigen
K7573_RS08935	COG3415	Transposase
K7573_RS08935	COG2801	Transposase and inactivated derivatives
K7573_RS08945	COG0431	NADPH-dependent FMN reductase
K7573_RS08955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7573_RS08960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7573_RS08965	COG1473	amidohydrolase
K7573_RS08980	COG1126	abc transporter atp-binding protein
K7573_RS08985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7573_RS09015	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K7573_RS09020	COG0583	DNA-binding transcription factor activity
K7573_RS09025	COG0477	Major facilitator Superfamily
K7573_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS09040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K7573_RS09060	COG1309	transcriptional regulator
K7573_RS09075	COG2801	Transposase and inactivated derivatives
K7573_RS09075	COG3415	Transposase
K7573_RS09080	COG0697	spore germination
K7573_RS09085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K7573_RS09090	COG0167	dihydroorotate dehydrogenase activity
K7573_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS09110	COG1012	belongs to the aldehyde dehydrogenase family
K7573_RS09150	COG0745	RESPONSE REGULATOR receiver
K7573_RS09155	COG4191	Histidine kinase
K7573_RS09155	COG0784	Response regulator, receiver
K7573_RS09160	COG2205	protein histidine kinase activity
K7573_RS09160	COG3437	response regulator, receiver
K7573_RS09160	COG3850	Histidine kinase
K7573_RS09160	COG4999	Histidine kinase
K7573_RS09165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K7573_RS09180	COG0640	Transcriptional regulator
K7573_RS09220	COG0527	aspartate kinase activity
K7573_RS09220	COG0460	homoserine dehydrogenase
K7573_RS09235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7573_RS09240	COG0124	histidyl-tRNA synthetase
K7573_RS09250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K7573_RS09255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K7573_RS09260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7573_RS09265	COG0131	Imidazoleglycerol-phosphate dehydratase
K7573_RS09265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K7573_RS09270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K7573_RS09275	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K7573_RS09280	COG0107	imidazoleglycerol-phosphate synthase activity
K7573_RS09285	COG0140	phosphoribosyl-ATP diphosphatase activity
K7573_RS09285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K7573_RS09305	COG1446	asparaginase
K7573_RS09310	COG3142	Participates in the control of copper homeostasis
K7573_RS09330	COG0789	Transcriptional regulator
K7573_RS09345	COG3537	Alpha-1,2-mannosidase
K7573_RS09350	COG1609	Transcriptional regulator
K7573_RS09360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7573_RS09375	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K7573_RS09380	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K7573_RS09385	COG0235	Class ii aldolase
K7573_RS09400	COG0531	amino acid
K7573_RS09405	COG0531	amino acid
K7573_RS09415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K7573_RS09420	COG0277	FAD linked oxidase domain protein
K7573_RS09435	COG2205	protein histidine kinase activity
K7573_RS09440	COG0745	RESPONSE REGULATOR receiver
K7573_RS09445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS09450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7573_RS09465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K7573_RS09510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K7573_RS09525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K7573_RS09530	COG0505	Belongs to the CarA family
K7573_RS09535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K7573_RS09540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7573_RS09555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K7573_RS09560	COG4676	Protein conserved in bacteria
K7573_RS09570	COG3279	Response regulator of the LytR AlgR family
K7573_RS09585	COG1012	belongs to the aldehyde dehydrogenase family
K7573_RS09605	COG0784	Response regulator, receiver
K7573_RS09605	COG2198	Histidine kinase
K7573_RS09605	COG2205	protein histidine kinase activity
K7573_RS09610	COG1024	Enoyl-CoA hydratase
K7573_RS09615	COG0318	PFAM AMP-dependent synthetase and ligase
K7573_RS09620	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K7573_RS09625	COG1012	belongs to the aldehyde dehydrogenase family
K7573_RS09630	COG1309	transcriptional regulator
K7573_RS09635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7573_RS09680	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K7573_RS09690	COG0840	transmembrane signaling receptor activity
K7573_RS09695	COG0840	transmembrane signaling receptor activity
K7573_RS09705	COG0835	chemotaxis
K7573_RS09710	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K7573_RS09715	COG0840	transmembrane signaling receptor activity
K7573_RS09725	COG0745	RESPONSE REGULATOR receiver
K7573_RS09735	COG0835	chemotaxis
K7573_RS09745	COG1360	Flagellar Motor Protein
K7573_RS09750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K7573_RS09755	COG0643	Histidine kinase
K7573_RS09755	COG2198	Histidine kinase
K7573_RS09755	COG0784	Response regulator, receiver
K7573_RS09760	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K7573_RS09785	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K7573_RS09790	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K7573_RS09810	COG1987	bacterial-type flagellum assembly
K7573_RS09820	COG3190	flagellar
K7573_RS09870	COG1677	Flagellar hook-basal body complex protein FliE
K7573_RS09900	COG2197	response regulator
K7573_RS09920	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K7573_RS09925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K7573_RS09960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K7573_RS09970	COG4787	bacterial-type flagellum-dependent cell motility
K7573_RS09985	COG1558	bacterial-type flagellum-dependent cell motility
K7573_RS09990	COG1815	bacterial-type flagellum-dependent cell motility
K7573_RS09995	COG0784	Response regulator, receiver
K7573_RS09995	COG0835	chemotaxis
K7573_RS10000	COG2801	Transposase and inactivated derivatives
K7573_RS10000	COG3415	Transposase
K7573_RS10020	COG5002	protein histidine kinase activity
K7573_RS10060	COG2915	High frequency lysogenization protein hflD homolog
K7573_RS10065	COG0482	sulfurtransferase activity
K7573_RS10080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K7573_RS10090	COG0542	response to heat
K7573_RS10120	COG0492	ferredoxin-NADP+ reductase activity
K7573_RS10125	COG1674	ftsk spoiiie
K7573_RS10140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K7573_RS10155	COG2819	hydrolase of the alpha beta superfamily
K7573_RS10165	COG4558	Periplasmic binding protein
K7573_RS10170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7573_RS10175	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K7573_RS10185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K7573_RS10235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K7573_RS10245	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
K7573_RS10260	COG1595	DNA-templated transcription, initiation
K7573_RS10280	COG0784	Response regulator, receiver
K7573_RS10285	COG4251	negative regulation of phosphorylation
K7573_RS10295	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K7573_RS10305	COG0456	acetyltransferase
K7573_RS10305	COG0454	-acetyltransferase
K7573_RS10310	COG2205	protein histidine kinase activity
K7573_RS10325	COG5290	Psort location Cytoplasmic, score
K7573_RS10355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K7573_RS10360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K7573_RS10365	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K7573_RS10370	COG2080	2 iron, 2 sulfur cluster binding
K7573_RS10380	COG1764	response to oxidative stress
K7573_RS10390	COG0583	DNA-binding transcription factor activity
K7573_RS10410	COG1595	DNA-templated transcription, initiation
K7573_RS10415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7573_RS10500	COG3685	Protein conserved in bacteria
K7573_RS10525	COG3546	catalase activity
K7573_RS10530	COG3685	Protein conserved in bacteria
K7573_RS10555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K7573_RS10575	COG1063	alcohol dehydrogenase
K7573_RS10605	COG1609	Transcriptional regulator
K7573_RS10610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K7573_RS10610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K7573_RS10615	COG1105	Belongs to the carbohydrate kinase PfkB family
K7573_RS10620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K7573_RS10620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K7573_RS10635	COG1733	regulation of RNA biosynthetic process
K7573_RS10640	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K7573_RS10655	COG4771	TonB-dependent receptor
K7573_RS10660	COG0738	Major facilitator superfamily
K7573_RS10665	COG1609	Transcriptional regulator
K7573_RS10685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K7573_RS10700	COG2828	Protein conserved in bacteria
K7573_RS10705	COG0583	DNA-binding transcription factor activity
K7573_RS10730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K7573_RS10735	COG0583	DNA-binding transcription factor activity
K7573_RS10765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7573_RS10770	COG3509	depolymerase
K7573_RS10790	COG0642	Histidine kinase
K7573_RS10800	COG0318	PFAM AMP-dependent synthetase and ligase
K7573_RS10815	COG2186	Transcriptional regulator
K7573_RS10835	COG2271	Major facilitator Superfamily
K7573_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS10850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7573_RS10875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K7573_RS10895	COG0583	DNA-binding transcription factor activity
K7573_RS10920	COG2204	response regulator
K7573_RS10995	COG0708	Exodeoxyribonuclease III
K7573_RS11000	COG0366	Alpha amylase catalytic
K7573_RS11005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7573_RS11015	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS11025	COG0577	efflux transmembrane transporter activity
K7573_RS11025	COG1136	(ABC) transporter
K7573_RS11030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS11040	COG0745	RESPONSE REGULATOR receiver
K7573_RS11045	COG2205	protein histidine kinase activity
K7573_RS11055	COG3214	Protein conserved in bacteria
K7573_RS11065	COG4774	siderophore transport
K7573_RS11085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K7573_RS11090	COG1285	pathogenesis
K7573_RS11095	COG4191	Histidine kinase
K7573_RS11100	COG4566	intracellular signal transduction
K7573_RS11175	COG0477	Major facilitator Superfamily
K7573_RS11200	COG1136	(ABC) transporter
K7573_RS11215	COG0583	DNA-binding transcription factor activity
K7573_RS11220	COG0656	L-ascorbic acid biosynthetic process
K7573_RS11240	COG0583	DNA-binding transcription factor activity
K7573_RS11245	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS11275	COG3537	Alpha-1,2-mannosidase
K7573_RS11290	COG0477	Major facilitator Superfamily
K7573_RS11310	COG3920	Histidine kinase
K7573_RS11310	COG2202	Pas domain
K7573_RS11355	COG1335	isochorismatase
K7573_RS11360	COG1335	isochorismatase
K7573_RS11390	COG0811	peptide transport
K7573_RS11530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K7573_RS11535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K7573_RS11545	COG0840	transmembrane signaling receptor activity
K7573_RS11550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K7573_RS11555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K7573_RS11560	COG4149	molybdate abc transporter
K7573_RS11565	COG0725	ABC transporter, periplasmic molybdate-binding protein
K7573_RS11570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7573_RS11585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K7573_RS11590	COG2181	nitrate reductase activity
K7573_RS11595	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
K7573_RS11600	COG1140	nitrate reductase beta subunit
K7573_RS11605	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K7573_RS11610	COG2223	nitrite transmembrane transporter activity
K7573_RS11620	COG0746	molybdenum cofactor guanylyltransferase activity
K7573_RS11625	COG0314	molybdopterin synthase activity
K7573_RS11635	COG0303	'Molybdopterin
K7573_RS11640	COG0521	Mo-molybdopterin cofactor biosynthetic process
K7573_RS11640	COG0315	cyclic pyranopterin monophosphate synthase activity
K7573_RS11645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K7573_RS11680	COG2207	Transcriptional regulator
K7573_RS11720	COG2205	protein histidine kinase activity
K7573_RS11750	COG2885	chlorophyll binding
K7573_RS11765	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS11770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K7573_RS11770	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K7573_RS11775	COG1535	isochorismatase
K7573_RS11775	COG3433	isochorismatase activity
K7573_RS11780	COG1535	isochorismatase
K7573_RS11780	COG3433	isochorismatase activity
K7573_RS11785	COG1021	2,3-dihydroxybenzoate-AMP ligase
K7573_RS11800	COG2409	Drug exporters of the RND superfamily
K7573_RS11805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7573_RS11860	COG4771	TonB-dependent receptor
K7573_RS11875	COG1914	H( )-stimulated, divalent metal cation uptake system
K7573_RS11895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7573_RS11900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7573_RS11905	COG0604	alcohol dehydrogenase
K7573_RS11905	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS11905	COG3321	synthase
K7573_RS11915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7573_RS11960	COG4772	TonB-dependent receptor
K7573_RS11980	COG2226	methyltransferase
K7573_RS12025	COG4964	Belongs to the GSP D family
K7573_RS12080	COG2814	Major facilitator Superfamily
K7573_RS12090	COG1228	amidohydrolase
K7573_RS12100	COG1335	isochorismatase
K7573_RS12115	COG3850	Histidine kinase
K7573_RS12120	COG2197	response regulator
K7573_RS12125	COG2814	Major facilitator Superfamily
K7573_RS12135	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K7573_RS12145	COG0583	DNA-binding transcription factor activity
K7573_RS12160	COG3161	chorismate lyase activity
K7573_RS12200	COG0277	FAD linked oxidase domain protein
K7573_RS12205	COG1304	FMN binding
K7573_RS12210	COG2186	Transcriptional regulator
K7573_RS12220	COG1285	pathogenesis
K7573_RS12245	COG2814	Major facilitator Superfamily
K7573_RS12300	COG0587	DNA-directed DNA polymerase activity
K7573_RS12315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K7573_RS12320	COG0519	Catalyzes the synthesis of GMP from XMP
K7573_RS12320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7573_RS12335	COG1595	DNA-templated transcription, initiation
K7573_RS12345	COG1629	transport
K7573_RS12345	COG4206	TonB-dependent receptor
K7573_RS12375	COG0531	amino acid
K7573_RS12390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7573_RS12400	COG0789	Transcriptional regulator
K7573_RS12485	COG5002	protein histidine kinase activity
K7573_RS12485	COG5001	Diguanylate cyclase
K7573_RS12485	COG3447	MASE1 domain protein
K7573_RS12490	COG2183	response to ionizing radiation
K7573_RS12505	COG1983	PspC domain protein
K7573_RS12515	COG3243	poly(R)-hydroxyalkanoic acid synthase
K7573_RS12535	COG0534	Mate efflux family protein
K7573_RS12555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K7573_RS12565	COG0668	transmembrane transport
K7573_RS12570	COG1902	pentaerythritol trinitrate reductase activity
K7573_RS12590	COG1733	regulation of RNA biosynthetic process
K7573_RS12595	COG2249	NAD(P)H dehydrogenase (quinone) activity
K7573_RS12600	COG0456	acetyltransferase
K7573_RS12680	COG3702	type iv secretory pathway
K7573_RS12700	COG2948	multi-organism process
K7573_RS12710	COG3736	Type IV secretory pathway, component VirB8
K7573_RS12720	COG3505	Type IV secretory pathway VirD4
K7573_RS12735	COG2814	Major facilitator Superfamily
K7573_RS12740	COG0789	Transcriptional regulator
K7573_RS12775	COG4191	Histidine kinase
K7573_RS12775	COG0784	Response regulator, receiver
K7573_RS12790	COG4774	siderophore transport
K7573_RS12810	COG1733	regulation of RNA biosynthetic process
K7573_RS12815	COG0604	alcohol dehydrogenase
K7573_RS12830	COG0210	DNA helicase
K7573_RS12845	COG0583	DNA-binding transcription factor activity
K7573_RS12850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K7573_RS12860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K7573_RS12875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K7573_RS12880	COG0077	Prephenate dehydratase
K7573_RS12880	COG1605	Chorismate mutase
K7573_RS12885	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K7573_RS12930	COG1228	amidohydrolase
K7573_RS12945	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K7573_RS12995	COG2957	Belongs to the agmatine deiminase family
K7573_RS13000	COG0583	DNA-binding transcription factor activity
K7573_RS13045	COG3415	Transposase
K7573_RS13045	COG2801	Transposase and inactivated derivatives
K7573_RS13055	COG4993	Dehydrogenase
K7573_RS13065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K7573_RS13075	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K7573_RS13085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K7573_RS13090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7573_RS13105	COG0359	binds to the 23S rRNA
K7573_RS13110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K7573_RS13115	COG0360	Binds together with S18 to 16S ribosomal RNA
K7573_RS13125	COG0316	Belongs to the HesB IscA family
K7573_RS13130	COG0017	Asparaginyl-tRNA synthetase
K7573_RS13150	COG0288	reversible hydration of carbon dioxide
K7573_RS13160	COG3844	kynureninase activity
K7573_RS13165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K7573_RS13170	COG2925	Exonuclease
K7573_RS13195	COG2902	Dehydrogenase
K7573_RS13205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS13210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7573_RS13225	COG1960	acyl-CoA dehydrogenase activity
K7573_RS13230	COG2226	methyltransferase
K7573_RS13240	COG0646	methionine synthase
K7573_RS13240	COG1410	methionine synthase
K7573_RS13255	COG2900	Belongs to the SlyX family
K7573_RS13270	COG0386	Belongs to the glutathione peroxidase family
K7573_RS13280	COG1725	Transcriptional regulator
K7573_RS13285	COG1131	(ABC) transporter
K7573_RS13310	COG0114	fumarate hydratase activity
K7573_RS13320	COG2850	peptidyl-arginine hydroxylation
K7573_RS13330	COG0567	Dehydrogenase, E1 component
K7573_RS13355	COG3540	Alkaline phosphatase
K7573_RS13365	COG0305	Participates in initiation and elongation during chromosome replication
K7573_RS13385	COG0625	glutathione transferase activity
K7573_RS13405	COG0084	hydrolase, TatD family'
K7573_RS13410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K7573_RS13445	COG0625	glutathione transferase activity
K7573_RS13460	COG1595	DNA-templated transcription, initiation
K7573_RS13465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K7573_RS13480	COG0386	Belongs to the glutathione peroxidase family
K7573_RS13485	COG0339	signal peptide processing
K7573_RS13495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K7573_RS13515	COG0705	Rhomboid family
K7573_RS13520	COG3104	oligopeptide transport
K7573_RS13530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K7573_RS13535	COG4290	ribonuclease
K7573_RS13550	COG0316	Belongs to the HesB IscA family
K7573_RS13550	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K7573_RS13555	COG2154	pterin-4-alpha-carbinolamine dehydratase
K7573_RS13565	COG0428	transporter
K7573_RS13575	COG1530	ribonuclease E activity
K7573_RS13590	COG0395	ABC-type sugar transport system, permease component
K7573_RS13620	COG0271	Belongs to the BolA IbaG family
K7573_RS13625	COG2350	Protein conserved in bacteria
K7573_RS13630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K7573_RS13635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K7573_RS13640	COG1187	pseudouridine synthase activity
K7573_RS13650	COG2814	Major facilitator Superfamily
K7573_RS13670	COG0436	Aminotransferase
K7573_RS13675	COG4133	protoheme IX ABC transporter activity
K7573_RS13695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K7573_RS13710	COG3088	subunit of a heme lyase
K7573_RS13710	COG4235	cytochrome complex assembly
K7573_RS13720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K7573_RS13730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K7573_RS13735	COG4988	ABC transporter
K7573_RS13745	COG1294	oxidase, subunit
K7573_RS13775	COG0726	polysaccharide deacetylase
K7573_RS13775	COG1649	PFAM Uncharacterised BCR, COG1649
K7573_RS13780	COG1215	transferase activity, transferring glycosyl groups
K7573_RS13790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K7573_RS13805	COG0165	Argininosuccinate lyase
K7573_RS13810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K7573_RS13820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K7573_RS13825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7573_RS13830	COG0137	argininosuccinate synthase activity
K7573_RS13835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K7573_RS13850	COG2166	iron-sulfur cluster assembly
K7573_RS13870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K7573_RS13890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K7573_RS13895	COG0402	S-adenosylhomocysteine deaminase activity
K7573_RS13900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K7573_RS13905	COG1509	lysine 2,3-aminomutase activity
K7573_RS13910	COG3300	MHYT domain
K7573_RS13910	COG5001	Diguanylate cyclase
K7573_RS13930	COG0501	Belongs to the peptidase M48B family
K7573_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS13960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K7573_RS13965	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7573_RS13970	COG0802	atpase or kinase
K7573_RS13975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K7573_RS13975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K7573_RS13980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K7573_RS13985	COG1570	exodeoxyribonuclease VII activity
K7573_RS13995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K7573_RS14015	COG4771	TonB-dependent receptor
K7573_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS14040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7573_RS14040	COG2169	Transcriptional regulator
K7573_RS14045	COG2130	NADP-dependent
K7573_RS14070	COG1960	acyl-CoA dehydrogenase activity
K7573_RS14080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K7573_RS14110	COG1309	transcriptional regulator
K7573_RS14115	COG2076	Multidrug Resistance protein
K7573_RS14120	COG5487	UPF0391 membrane protein
K7573_RS14125	COG1280	lysine exporter protein (LysE YggA)
K7573_RS14130	COG1794	racemase activity, acting on amino acids and derivatives
K7573_RS14165	COG0776	regulation of translation
K7573_RS14170	COG0072	phenylalanine-tRNA ligase activity
K7573_RS14170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7573_RS14175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K7573_RS14180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K7573_RS14185	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K7573_RS14190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K7573_RS14195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K7573_RS14230	COG1185	polyribonucleotide nucleotidyltransferase activity
K7573_RS14235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K7573_RS14245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K7573_RS14250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K7573_RS14255	COG0195	Participates in both transcription termination and antitermination
K7573_RS14260	COG0779	Required for maturation of 30S ribosomal subunits
K7573_RS14275	COG1007	ATP synthesis coupled electron transport
K7573_RS14290	COG0713	ATP synthesis coupled electron transport
K7573_RS14300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7573_RS14305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K7573_RS14320	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K7573_RS14325	COG0649	NAD binding
K7573_RS14330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7573_RS14335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7573_RS14340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7573_RS14355	COG0149	triose-phosphate isomerase activity
K7573_RS14365	COG3083	sulfuric ester hydrolase activity
K7573_RS14370	COG0438	transferase activity, transferring glycosyl groups
K7573_RS14375	COG0726	polysaccharide deacetylase
K7573_RS14380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K7573_RS14385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7573_RS14390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K7573_RS14395	COG0159	tryptophan synthase activity
K7573_RS14405	COG0133	tryptophan synthase activity
K7573_RS14425	COG0135	phosphoribosylanthranilate isomerase activity
K7573_RS14430	COG0101	tRNA pseudouridine synthase activity
K7573_RS14445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K7573_RS14455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K7573_RS14460	COG2890	protein-(glutamine-N5) methyltransferase activity
K7573_RS14465	COG1999	signal sequence binding
K7573_RS14470	COG0688	phosphatidylethanolamine metabolic process
K7573_RS14485	COG0433	COG0433 Predicted ATPase
K7573_RS14490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7573_RS14500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7573_RS14505	COG0412	Dienelactone hydrolase
K7573_RS14520	COG0717	Belongs to the dCTP deaminase family
K7573_RS14525	COG0489	protein tyrosine kinase activity
K7573_RS14530	COG4771	TonB-dependent receptor
K7573_RS14540	COG4771	TonB-dependent receptor
K7573_RS14550	COG3590	peptidase
K7573_RS14585	COG0697	spore germination
K7573_RS14595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7573_RS14600	COG2311	Membrane
K7573_RS14605	COG1047	Peptidyl-prolyl cis-trans
K7573_RS14610	COG0791	NLP P60 protein
K7573_RS14615	COG0791	NLP P60 protein
K7573_RS14620	COG1301	dicarboxylic acid transport
K7573_RS14640	COG1722	exodeoxyribonuclease VII activity
K7573_RS14645	COG0142	geranyltranstransferase activity
K7573_RS14655	COG0312	modulator of DNA gyrase
K7573_RS14660	COG3028	Belongs to the UPF0307 family
K7573_RS14665	COG0312	modulator of DNA gyrase
K7573_RS14685	COG2968	Membrane
K7573_RS14710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K7573_RS14720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K7573_RS14735	COG0495	leucyl-tRNA aminoacylation
K7573_RS14745	COG3118	belongs to the thioredoxin family
K7573_RS14755	COG3706	GGDEF domain
K7573_RS14755	COG2203	Gaf domain
K7573_RS14755	COG5001	Diguanylate cyclase
K7573_RS14755	COG4251	negative regulation of phosphorylation
K7573_RS14780	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K7573_RS14790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K7573_RS14795	COG0346	lactoylglutathione lyase activity
K7573_RS14805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7573_RS14805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7573_RS14815	COG2878	Part of a membrane complex involved in electron transport
K7573_RS14825	COG0251	oxidation-reduction process
K7573_RS14830	COG0392	lysyltransferase activity
K7573_RS14830	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K7573_RS14860	COG2824	Alkylphosphonate utilization operon protein PhnA
K7573_RS14865	COG0443	Heat shock 70 kDa protein
K7573_RS14905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K7573_RS14910	COG3122	Protein conserved in bacteria
K7573_RS14915	COG1451	nucleotide metabolic process
K7573_RS14925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7573_RS14945	COG0183	Belongs to the thiolase family
K7573_RS14960	COG1960	acyl-CoA dehydrogenase activity
K7573_RS14970	COG1793	dna ligase
K7573_RS14975	COG1201	RNA secondary structure unwinding
K7573_RS14995	COG1278	Cold shock
K7573_RS15000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K7573_RS15005	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K7573_RS15010	COG1472	Belongs to the glycosyl hydrolase 3 family
K7573_RS15015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K7573_RS15020	COG2954	triphosphatase activity
K7573_RS15025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K7573_RS15030	COG0745	RESPONSE REGULATOR receiver
K7573_RS15035	COG1381	Involved in DNA repair and RecF pathway recombination
K7573_RS15040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K7573_RS15055	COG0681	Belongs to the peptidase S26 family
K7573_RS15060	COG0481	GTPase activity
K7573_RS15065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7573_RS15085	COG1741	Belongs to the pirin family
K7573_RS15090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K7573_RS15100	COG1741	Belongs to the pirin family
K7573_RS15105	COG1966	Carbon starvation protein
K7573_RS15110	COG2879	small protein
K7573_RS15125	COG2205	protein histidine kinase activity
K7573_RS15170	COG2814	Major facilitator Superfamily
K7573_RS15175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K7573_RS15175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K7573_RS15185	COG1113	amino acid transport
K7573_RS15190	COG2207	Transcriptional regulator
K7573_RS15190	COG1917	Cupin 2, conserved barrel domain protein
K7573_RS15195	COG0753	catalase activity
K7573_RS15225	COG1376	ErfK ybiS ycfS ynhG family protein
K7573_RS15230	COG0739	heme binding
K7573_RS15240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K7573_RS15250	COG0330	HflC and HflK could
K7573_RS15255	COG0330	HflC and HflK could
K7573_RS15260	COG0604	alcohol dehydrogenase
K7573_RS15275	COG0678	peroxiredoxin activity
K7573_RS15285	COG4953	penicillin-binding protein 1C
K7573_RS15290	COG2373	Large extracellular alpha-helical protein
K7573_RS15300	COG2828	Protein conserved in bacteria
K7573_RS15310	COG3609	addiction module antidote protein, CC2985 family
K7573_RS15330	COG3829	transcription factor binding
K7573_RS15350	COG0259	pyridoxamine-phosphate oxidase activity
K7573_RS15365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K7573_RS15385	COG0477	Major facilitator Superfamily
K7573_RS15390	COG0784	Response regulator, receiver
K7573_RS15390	COG5002	protein histidine kinase activity
K7573_RS15390	COG2198	Histidine kinase
K7573_RS15405	COG3038	cytochrome b561
K7573_RS15420	COG1760	l-serine dehydratase
K7573_RS15425	COG2267	carboxylic ester hydrolase activity
K7573_RS15430	COG0460	homoserine dehydrogenase
K7573_RS15430	COG0527	aspartate kinase activity
K7573_RS15435	COG0626	cystathionine gamma-synthase activity
K7573_RS15440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K7573_RS15445	COG0739	heme binding
K7573_RS15450	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K7573_RS15455	COG1272	protein, Hemolysin III
K7573_RS15470	COG0463	Glycosyl transferase, family 2
K7573_RS15475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7573_RS15480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K7573_RS15495	COG1309	transcriptional regulator
K7573_RS15505	COG1960	acyl-CoA dehydrogenase activity
K7573_RS15555	COG0509	glycine decarboxylation via glycine cleavage system
K7573_RS15560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K7573_RS15570	COG0330	HflC and HflK could
K7573_RS15580	COG1742	UPF0060 membrane protein
K7573_RS15585	COG3956	TIGRFAM MazG family protein
K7573_RS15595	COG0494	nUDIX hydrolase
K7573_RS15605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K7573_RS15620	COG0643	Histidine kinase
K7573_RS15620	COG0784	Response regulator, receiver
K7573_RS15620	COG2198	Histidine kinase
K7573_RS15625	COG0840	transmembrane signaling receptor activity
K7573_RS15630	COG0835	chemotaxis
K7573_RS15645	COG0189	ligase activity
K7573_RS15660	COG1199	ATP-dependent helicase activity
K7573_RS15670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K7573_RS15675	COG1215	transferase activity, transferring glycosyl groups
K7573_RS15690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7573_RS15700	COG1643	Atp-dependent helicase
K7573_RS15705	COG0783	Belongs to the Dps family
K7573_RS15710	COG0514	ATP-dependent DNA helicase (RecQ)
K7573_RS15775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K7573_RS15780	COG0602	queuosine metabolic process
K7573_RS15790	COG2885	chlorophyll binding
K7573_RS15795	COG0823	Involved in the tonB-independent uptake of proteins
K7573_RS15810	COG0811	peptide transport
K7573_RS15815	COG0824	Thioesterase
K7573_RS15820	COG2255	four-way junction helicase activity
K7573_RS15830	COG0632	four-way junction helicase activity
K7573_RS15835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K7573_RS15840	COG0217	transcriptional regulatory protein
K7573_RS15860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K7573_RS15890	COG0488	(ABC) transporter
K7573_RS15915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K7573_RS15915	COG4651	solute:proton antiporter activity
K7573_RS15925	COG0745	RESPONSE REGULATOR receiver
K7573_RS15930	COG2205	protein histidine kinase activity
K7573_RS15940	COG0542	response to heat
K7573_RS15960	COG0028	Belongs to the TPP enzyme family
K7573_RS15985	COG3387	PFAM Glycoside hydrolase 15-related
K7573_RS15990	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
K7573_RS15995	COG3011	Protein conserved in bacteria
K7573_RS16010	COG0564	pseudouridine synthase activity
K7573_RS16015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7573_RS16030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K7573_RS16030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7573_RS16040	COG0045	succinate-CoA ligase (ADP-forming) activity
K7573_RS16075	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K7573_RS16095	COG0745	RESPONSE REGULATOR receiver
K7573_RS16110	COG0189	ligase activity
K7573_RS16135	COG4625	pathogenesis
K7573_RS16135	COG3240	lipase activity
K7573_RS16145	COG2022	thiamine diphosphate biosynthetic process
K7573_RS16150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K7573_RS16155	COG0471	metal ion transport
K7573_RS16155	COG3273	potassium ion transport
K7573_RS16175	COG1970	mechanosensitive ion channel activity
K7573_RS16185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7573_RS16190	COG1115	amino acid carrier protein
K7573_RS16200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7573_RS16205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS16230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K7573_RS16240	COG3588	fructose-bisphosphate aldolase
K7573_RS16245	COG0469	pyruvate kinase activity
K7573_RS16255	COG0126	phosphoglycerate kinase activity
K7573_RS16270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K7573_RS16315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K7573_RS16320	COG1301	dicarboxylic acid transport
K7573_RS16350	COG0714	Associated with various cellular activities
K7573_RS16380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K7573_RS16395	COG5295	Hep Hag repeat protein
K7573_RS16430	COG0254	rRNA binding
K7573_RS16445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K7573_RS16455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7573_RS16460	COG1758	RNA polymerase activity
K7573_RS16475	COG0437	4 iron, 4 sulfur cluster binding
K7573_RS16480	COG2864	formate dehydrogenase
K7573_RS16490	COG1921	L-seryl-tRNASec selenium transferase activity
K7573_RS16495	COG3276	selenocysteine insertion sequence binding
K7573_RS16505	COG0709	Synthesizes selenophosphate from selenide and ATP
K7573_RS16510	COG1561	YicC-like family, N-terminal region
K7573_RS16515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K7573_RS16520	COG0346	lactoylglutathione lyase activity
K7573_RS16530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K7573_RS16545	COG0006	proline dipeptidase activity
K7573_RS16550	COG0006	proline dipeptidase activity
K7573_RS16555	COG3079	Belongs to the UPF0149 family
K7573_RS16575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K7573_RS16585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K7573_RS16595	COG2912	Transglutaminase-like superfamily
K7573_RS16600	COG1773	rubredoxin
K7573_RS16605	COG0352	thiamine-phosphate diphosphorylase activity
K7573_RS16610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K7573_RS16615	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K7573_RS16625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K7573_RS16630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7573_RS16640	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS16660	COG0671	phosphoesterase, PA-phosphatase related
K7573_RS16670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K7573_RS16675	COG0563	adenylate kinase activity
K7573_RS16695	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K7573_RS16705	COG0848	biopolymer transport protein
K7573_RS16715	COG2832	Protein of unknown function (DUF454)
K7573_RS16750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K7573_RS16775	COG0745	RESPONSE REGULATOR receiver
K7573_RS16785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K7573_RS16790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K7573_RS16800	COG0405	Gamma-glutamyltransferase
K7573_RS16805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K7573_RS16825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K7573_RS16830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K7573_RS16845	COG0473	3-isopropylmalate dehydrogenase activity
K7573_RS16860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7573_RS16865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS16875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K7573_RS16880	COG1538	Outer membrane efflux protein
K7573_RS16885	COG0531	amino acid
K7573_RS16890	COG1519	Transferase
K7573_RS16895	COG1560	Kdo2-lipid A biosynthetic process
K7573_RS16935	COG1301	dicarboxylic acid transport
K7573_RS16945	COG4191	Histidine kinase
K7573_RS16960	COG0642	Histidine kinase
K7573_RS16975	COG2851	Citrate transporter
K7573_RS16980	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS17005	COG1162	GTPase activity
K7573_RS17010	COG0436	Aminotransferase
K7573_RS17030	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K7573_RS17045	COG1228	amidohydrolase
K7573_RS17050	COG0804	urea catabolic process
K7573_RS17060	COG1307	EDD domain protein, DegV family
K7573_RS17100	COG5001	Diguanylate cyclase
K7573_RS17100	COG4251	negative regulation of phosphorylation
K7573_RS17100	COG2203	Gaf domain
K7573_RS17100	COG3706	GGDEF domain
K7573_RS17105	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K7573_RS17115	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K7573_RS17130	COG1902	pentaerythritol trinitrate reductase activity
K7573_RS17155	COG0583	DNA-binding transcription factor activity
K7573_RS17160	COG1064	alcohol dehydrogenase
K7573_RS17180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K7573_RS17185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K7573_RS17195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K7573_RS17200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K7573_RS17215	COG1522	sequence-specific DNA binding
K7573_RS17225	COG4773	Receptor
K7573_RS17250	COG0617	tRNA 3'-terminal CCA addition
K7573_RS17295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K7573_RS17300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7573_RS17305	COG1609	Transcriptional regulator
K7573_RS17315	COG0837	glucose binding
K7573_RS17325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K7573_RS17345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K7573_RS17375	COG4191	Histidine kinase
K7573_RS17380	COG0784	Response regulator, receiver
K7573_RS17385	COG4251	negative regulation of phosphorylation
K7573_RS17390	COG2823	Periplasmic or secreted lipoprotein
K7573_RS17395	COG0673	inositol 2-dehydrogenase activity
K7573_RS17400	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K7573_RS17420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K7573_RS17430	COG2921	Belongs to the UPF0250 family
K7573_RS17440	COG1686	Belongs to the peptidase S11 family
K7573_RS17445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K7573_RS17450	COG2951	lytic endotransglycosylase activity
K7573_RS17455	COG0772	Belongs to the SEDS family
K7573_RS17460	COG0772	Belongs to the SEDS family
K7573_RS17475	COG1792	Involved in formation and maintenance of cell shape
K7573_RS17480	COG1077	Cell shape determining protein MreB Mrl
K7573_RS17485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7573_RS17500	COG0308	aminopeptidase N
K7573_RS17505	COG2226	methyltransferase
K7573_RS17535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7573_RS17550	COG0673	inositol 2-dehydrogenase activity
K7573_RS17560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K7573_RS17580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K7573_RS17590	COG2832	Protein of unknown function (DUF454)
K7573_RS17600	COG0436	Aminotransferase
K7573_RS17605	COG1505	serine-type exopeptidase activity
K7573_RS17630	COG0697	spore germination
K7573_RS17635	COG1666	GTP binding
K7573_RS17650	COG0339	signal peptide processing
K7573_RS17660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7573_RS17680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7573_RS17690	COG1136	(ABC) transporter
K7573_RS17695	COG1136	(ABC) transporter
K7573_RS17695	COG0577	efflux transmembrane transporter activity
K7573_RS17700	COG0577	efflux transmembrane transporter activity
K7573_RS17710	COG2204	response regulator
K7573_RS17715	COG4191	Histidine kinase
K7573_RS17725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K7573_RS17740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K7573_RS17745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K7573_RS17750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K7573_RS17755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K7573_RS17760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K7573_RS17765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K7573_RS17775	COG0356	it plays a direct role in the translocation of protons across the membrane
K7573_RS17790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K7573_RS17795	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7573_RS17815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K7573_RS17840	COG0181	hydroxymethylbilane synthase activity
K7573_RS17850	COG2972	Histidine kinase
K7573_RS17850	COG0745	RESPONSE REGULATOR receiver
K7573_RS17855	COG0400	carboxylic ester hydrolase activity
K7573_RS17865	COG4771	TonB-dependent receptor
K7573_RS17895	COG0477	Major facilitator Superfamily
K7573_RS17945	COG4206	TonB-dependent receptor
K7573_RS17965	COG0625	glutathione transferase activity
K7573_RS17980	COG2259	Doxx family
K7573_RS18005	COG4695	Portal protein
K7573_RS18055	COG0582	viral genome integration into host DNA
K7573_RS18070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K7573_RS18075	COG1490	D-aminoacyl-tRNA deacylase activity
K7573_RS18085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K7573_RS18125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K7573_RS18125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K7573_RS18130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K7573_RS18135	COG0242	peptide deformylase activity
K7573_RS18145	COG0758	DNA mediated transformation
K7573_RS18150	COG2922	Belongs to the Smg family
K7573_RS18160	COG1714	RDD family
K7573_RS18165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K7573_RS18165	COG1754	DNA topoisomerase type I activity
K7573_RS18170	COG0009	L-threonylcarbamoyladenylate synthase
K7573_RS18185	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS18195	COG0616	signal peptide processing
K7573_RS18200	COG0534	Mate efflux family protein
K7573_RS18215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K7573_RS18220	COG0625	glutathione transferase activity
K7573_RS18230	COG1252	NADH dehydrogenase
K7573_RS18255	COG2860	membrane
K7573_RS18260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K7573_RS18280	COG1846	Transcriptional regulator
K7573_RS18310	COG0459	protein refolding
K7573_RS18315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K7573_RS18320	COG2356	endonuclease I
K7573_RS18325	COG1324	tolerance protein
K7573_RS18335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7573_RS18345	COG0840	transmembrane signaling receptor activity
K7573_RS18365	COG4585	Histidine kinase
K7573_RS18385	COG0583	DNA-binding transcription factor activity
K7573_RS18400	COG1785	Belongs to the alkaline phosphatase family
K7573_RS18405	COG1686	Belongs to the peptidase S11 family
K7573_RS18415	COG2249	NAD(P)H dehydrogenase (quinone) activity
K7573_RS18425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K7573_RS18440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K7573_RS18445	COG0511	ligase activity, forming carbon-carbon bonds
K7573_RS18450	COG0439	Biotin carboxylase
K7573_RS18465	COG2264	protein methyltransferase activity
K7573_RS18475	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K7573_RS18480	COG4589	Belongs to the CDS family
K7573_RS18485	COG0204	Acyl-transferase
K7573_RS18495	COG0671	phosphoesterase, PA-phosphatase related
K7573_RS18495	COG2453	phosphatase
K7573_RS18500	COG2267	carboxylic ester hydrolase activity
K7573_RS18505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K7573_RS18510	COG0138	bifunctional purine biosynthesis protein purh
K7573_RS18515	COG0151	Belongs to the GarS family
K7573_RS18530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K7573_RS18535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K7573_RS18540	COG2201	protein-glutamate methylesterase activity
K7573_RS18545	COG2177	Part of the ABC transporter FtsEX involved in
K7573_RS18550	COG2884	Cell division ATP-binding protein ftsE
K7573_RS18560	COG3118	belongs to the thioredoxin family
K7573_RS18565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K7573_RS18570	COG3706	GGDEF domain
K7573_RS18580	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
K7573_RS18615	COG1652	LysM domain
K7573_RS18620	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K7573_RS18620	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K7573_RS18625	COG1473	amidohydrolase
K7573_RS18630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS18635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7573_RS18640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K7573_RS18645	COG1289	transmembrane transporter activity
K7573_RS18650	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS18655	COG2814	Major facilitator Superfamily
K7573_RS18685	COG0316	Belongs to the HesB IscA family
K7573_RS18710	COG5002	protein histidine kinase activity
K7573_RS18710	COG2205	protein histidine kinase activity
K7573_RS18710	COG0784	Response regulator, receiver
K7573_RS18725	COG1051	belongs to the nudix hydrolase family
K7573_RS18740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K7573_RS18745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K7573_RS18750	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K7573_RS18760	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K7573_RS18765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7573_RS18770	COG0730	response to heat
K7573_RS18780	COG0134	indole-3-glycerol-phosphate synthase activity
K7573_RS18785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K7573_RS18805	COG2801	Transposase and inactivated derivatives
K7573_RS18805	COG3415	Transposase
K7573_RS18810	COG1597	lipid kinase activity
K7573_RS18825	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K7573_RS18830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K7573_RS18840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K7573_RS18840	COG2111	Na H antiporter
K7573_RS18845	COG1006	Multisubunit Na H antiporter MnhC subunit
K7573_RS18850	COG0651	ATP synthesis coupled electron transport
K7573_RS18855	COG1863	multisubunit Na H antiporter MnhE subunit
K7573_RS18860	COG2212	antiporter activity
K7573_RS18865	COG1320	monovalent cation:proton antiporter activity
K7573_RS18870	COG0530	calcium, potassium:sodium antiporter activity
K7573_RS18885	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K7573_RS18900	COG4804	nuclease activity
K7573_RS18915	COG3104	oligopeptide transport
K7573_RS18920	COG3483	tryptophan 2,3-dioxygenase activity
K7573_RS18950	COG3415	Transposase
K7573_RS18950	COG2801	Transposase and inactivated derivatives
K7573_RS18955	COG2378	regulation of single-species biofilm formation
K7573_RS18970	COG2354	Protein conserved in bacteria
K7573_RS18975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K7573_RS18980	COG1368	sulfuric ester hydrolase activity
K7573_RS18985	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K7573_RS18985	COG3264	Mechanosensitive ion channel
K7573_RS19000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K7573_RS19035	COG1166	arginine decarboxylase activity
K7573_RS19040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K7573_RS19065	COG2960	long-chain fatty acid transporting porin activity
K7573_RS19125	COG0606	chelatase, subunit chli
K7573_RS19145	COG0561	phosphatase activity
K7573_RS19150	COG3932	Exopolysaccharide synthesis, ExoD
K7573_RS19180	COG1999	signal sequence binding
K7573_RS19185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K7573_RS19190	COG1845	cytochrome c oxidase, subunit III
K7573_RS19200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K7573_RS19205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7573_RS19220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7573_RS19225	COG1104	cysteine desulfurase activity
K7573_RS19280	COG2031	fatty acid transporter
K7573_RS19340	COG0673	inositol 2-dehydrogenase activity
K7573_RS19350	COG1501	Belongs to the glycosyl hydrolase 31 family
K7573_RS19355	COG2222	sugar isomerase
K7573_RS19360	COG1940	carbohydrate kinase activity
K7573_RS19370	COG1349	DNA-binding transcription factor activity
K7573_RS19375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K7573_RS19380	COG2814	Major facilitator Superfamily
K7573_RS19425	COG3210	domain, Protein
K7573_RS19445	COG1040	competence protein
K7573_RS19465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K7573_RS19470	COG0156	8-amino-7-oxononanoate synthase activity
K7573_RS19475	COG2267	carboxylic ester hydrolase activity
K7573_RS19480	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS19495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K7573_RS19520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7573_RS19525	COG2205	protein histidine kinase activity
K7573_RS19530	COG0745	RESPONSE REGULATOR receiver
K7573_RS19535	COG3541	Predicted nucleotidyltransferase
K7573_RS19540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K7573_RS19565	COG0714	Associated with various cellular activities
K7573_RS19580	COG0754	glutathionylspermidine amidase activity
K7573_RS19590	COG0129	dihydroxy-acid dehydratase activity
K7573_RS19595	COG1199	ATP-dependent helicase activity
K7573_RS19605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K7573_RS19625	COG3781	membrane
K7573_RS19655	COG0625	glutathione transferase activity
K7573_RS19675	COG2207	Transcriptional regulator
K7573_RS19690	COG4555	ABC transporter
K7573_RS19720	COG0543	2 iron, 2 sulfur cluster binding
K7573_RS19720	COG0633	Ferredoxin
K7573_RS19725	COG1131	(ABC) transporter
K7573_RS19730	COG0842	Transport permease protein
K7573_RS19740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K7573_RS19750	COG0084	hydrolase, TatD family'
K7573_RS19755	COG1643	Atp-dependent helicase
K7573_RS19765	COG1187	pseudouridine synthase activity
K7573_RS19780	COG0667	Aldo Keto reductase
K7573_RS19795	COG1690	Belongs to the RtcB family
K7573_RS19810	COG0840	transmembrane signaling receptor activity
K7573_RS19815	COG0583	DNA-binding transcription factor activity
K7573_RS19820	COG2814	Major facilitator Superfamily
K7573_RS19825	COG0656	L-ascorbic acid biosynthetic process
K7573_RS19850	COG2267	carboxylic ester hydrolase activity
K7573_RS19880	COG0045	succinate-CoA ligase (ADP-forming) activity
K7573_RS19880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K7573_RS19880	COG1042	CoA-binding domain protein
K7573_RS19885	COG2239	Acts as a magnesium transporter
K7573_RS19895	COG3177	Filamentation induced by cAMP protein fic
K7573_RS19895	COG0666	response to abiotic stimulus
K7573_RS19900	COG3100	YcgL domain-containing protein
K7573_RS19910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7573_RS19915	COG1028	Short-chain dehydrogenase reductase Sdr
K7573_RS19935	COG0644	oxidoreductase
K7573_RS19955	COG2986	histidine ammonia-lyase
K7573_RS19965	COG0463	Glycosyl transferase, family 2
K7573_RS19980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7573_RS19985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7573_RS20000	COG1294	oxidase, subunit
K7573_RS20005	COG1271	oxidase subunit
K7573_RS20060	COG0408	coproporphyrinogen oxidase activity
K7573_RS20070	COG2323	membrane
K7573_RS20085	COG0589	response to stress
K7573_RS20110	COG0210	DNA helicase
K7573_RS20120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7573_RS20125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K7573_RS20130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K7573_RS20135	COG1819	glycosyl
K7573_RS20150	COG0251	oxidation-reduction process
K7573_RS20185	COG0463	Glycosyl transferase, family 2
K7573_RS20200	COG1475	DNA binding
K7573_RS20205	COG1192	Involved in chromosome partitioning
K7573_RS20210	COG0357	Ribosomal RNA small subunit methyltransferase G
K7573_RS20215	COG2091	lysine biosynthetic process via aminoadipic acid
K7573_RS20255	COG1971	Probably functions as a manganese efflux pump
K7573_RS20260	COG2205	protein histidine kinase activity
K7573_RS20260	COG0784	Response regulator, receiver
K7573_RS20270	COG0443	Heat shock 70 kDa protein
K7573_RS20280	COG2911	Protein conserved in bacteria
K7573_RS20285	COG0729	surface antigen
K7573_RS20295	COG0752	glycyl-tRNA synthetase alpha subunit
K7573_RS20300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K7573_RS20305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7573_RS20305	COG0519	Catalyzes the synthesis of GMP from XMP
K7573_RS20315	COG0805	protein transport
K7573_RS20325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K7573_RS20335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K7573_RS20340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K7573_RS20340	COG0596	Alpha beta hydrolase
K7573_RS20345	COG0840	transmembrane signaling receptor activity
K7573_RS20400	COG3135	benzoate transporter
K7573_RS20415	COG2951	lytic endotransglycosylase activity
K7573_RS20420	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K7573_RS20425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K7573_RS20430	COG3706	GGDEF domain
K7573_RS20460	COG0302	gtp cyclohydrolase
K7573_RS20475	COG1566	PFAM secretion protein HlyD family protein
K7573_RS20485	COG1289	transmembrane transporter activity
K7573_RS20500	COG1074	ATP-dependent DNA helicase activity
K7573_RS20505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K7573_RS20510	COG1127	ABC transporter
K7573_RS20515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K7573_RS20520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K7573_RS20535	COG2853	Lipoprotein
K7573_RS20540	COG0386	Belongs to the glutathione peroxidase family
K7573_RS20550	COG1322	Protein conserved in bacteria
K7573_RS20560	COG0604	alcohol dehydrogenase
K7573_RS20565	COG0583	DNA-binding transcription factor activity
K7573_RS20585	COG0531	amino acid
K7573_RS20595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K7573_RS20600	COG0861	Integral membrane protein TerC family
K7573_RS20610	COG0584	glycerophosphoryl diester phosphodiesterase
K7573_RS20625	COG0706	membrane insertase activity
K7573_RS20630	COG0594	ribonuclease P activity
K7573_RS20635	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K7573_RS20720	COG1192	Involved in chromosome partitioning
K7573_RS20725	COG1475	DNA binding
K7573_RS20790	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
K7573_RS20795	COG2948	multi-organism process
K7573_RS20800	COG3504	Conjugal transfer protein
K7573_RS20870	COG2165	general secretion pathway protein
K7573_RS20880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K7573_RS21030	COG2003	Belongs to the UPF0758 family
K7573_RS21060	COG0582	viral genome integration into host DNA
K7573_RS21080	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K7573_RS21120	COG1196	nuclear chromosome segregation
K7573_RS21170	COG1030	water channel activity
K7573_RS21190	COG4220	transposase activity
K7573_RS21205	COG5562	phage envelope protein
K7573_RS21235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP