locus-tag class description HKK60_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HKK60_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HKK60_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HKK60_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKK60_RS00025 ENOG4108TYN CAAX amino terminal protease family protein HKK60_RS00030 ENOG4108K0D peptidase, M48 HKK60_RS00060 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HKK60_RS00085 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HKK60_RS00090 ENOG4105CGF Aromatic amino acid aminotransferase HKK60_RS00095 ENOG4105CHB tonB-dependent Receptor HKK60_RS00115 ENOG4105DQE DNA ligase HKK60_RS00130 ENOG4108UHU Aldolase HKK60_RS00140 ENOG4105ETE Transcriptional regulator (LacI family HKK60_RS00145 ENOG4105MIR Phenylalanine 4-monooxygenase HKK60_RS00150 ENOG4105EW9 transcriptional regulator AsnC family HKK60_RS00155 ENOG4105D78 K07001 NTE family protein HKK60_RS00165 ENOG4107ZSV Receptor HKK60_RS00185 ENOG4105DKW ABC transporter HKK60_RS00200 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HKK60_RS00205 ENOG4105DJ9 glucan biosynthesis protein HKK60_RS00210 ENOG4107104 thymidine kinase HKK60_RS00225 ENOG4105C4R Atp-dependent dna helicase HKK60_RS00235 ENOG4108YXG UPF0502 protein HKK60_RS00240 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HKK60_RS00245 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HKK60_RS00255 ENOG4105E55 glycerol-3-phosphate acyltransferase HKK60_RS00265 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HKK60_RS00270 ENOG4105DH7 May be involved in recombination (By similarity) HKK60_RS00280 ENOG4108Z5K methylglyoxal synthase HKK60_RS00285 ENOG4105BZU Histidine kinase HKK60_RS00290 ENOG4105BZ8 glutamate synthase HKK60_RS00295 ENOG4105CBC glutamate synthase HKK60_RS00315 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HKK60_RS00330 ENOG4108A04 Beta-lactamase HKK60_RS00355 ENOG4108I5C dEAD DEAH box helicase HKK60_RS00390 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HKK60_RS00410 ENOG4105CMS peptidase U62, modulator of DNA gyrase HKK60_RS00420 ENOG4105CAF HipA N-terminal domain protein HKK60_RS00440 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HKK60_RS00460 ENOG4107RZC phospholipase d HKK60_RS00465 ENOG4105KA0 thioesterase Superfamily protein HKK60_RS00470 ENOG4105E9Q Acyl-transferase HKK60_RS00485 ENOG4108V1U phospholipid-binding protein HKK60_RS00500 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HKK60_RS00505 ENOG4105C5F glutamine synthetase HKK60_RS00515 ENOG4105BZU Histidine kinase HKK60_RS00520 ENOG4105D5K Hemolysin activator protein HKK60_RS00525 ENOG4105CKT filamentous hemagglutinin HKK60_RS00525 ENOG4105CKT filamentous hemagglutinin HKK60_RS00555 ENOG4105CA3 membrane-bound lytic murein transglycosylase HKK60_RS00570 ENOG4105CUX Signal transduction histidine kinase HKK60_RS00575 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HKK60_RS00580 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKK60_RS00585 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKK60_RS00595 ENOG4105CHU acetyl-coa acetyltransferase HKK60_RS00630 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HKK60_RS00635 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HKK60_RS00655 ENOG4105D6J arsenicaL-resistance protein HKK60_RS00670 ENOG4105CAU Arsenical resistance protein, ArsH HKK60_RS00705 ENOG4105EZR dyp-type peroxidase family protein HKK60_RS00745 ENOG41068CG regulatoR HKK60_RS00750 ENOG4105BZU Histidine kinase HKK60_RS00760 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HKK60_RS00765 ENOG4105C1G acyl-Coa dehydrogenase HKK60_RS00770 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HKK60_RS00790 ENOG4105E2T synthase III HKK60_RS00795 ENOG4108J2P Alpha beta hydrolase fold HKK60_RS00805 ENOG410680H amp-dependent synthetase and ligase HKK60_RS00810 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HKK60_RS00820 ENOG4105CPF Cell wall formation (By similarity) HKK60_RS00830 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HKK60_RS00845 ENOG4108PBI Polysaccharide metabolism HKK60_RS00850 ENOG4107W19 lmbE family HKK60_RS00860 ENOG4105DR9 pseudouridine synthase HKK60_RS00870 ENOG4108YZN class I peptide chain release factor HKK60_RS00880 ENOG4105DGW oligopeptidase A HKK60_RS00895 ENOG4105C3F Signal peptidase i HKK60_RS00900 ENOG4105D94 Major Facilitator Superfamily HKK60_RS00905 ENOG4106NZI LysR family Transcriptional regulator HKK60_RS00910 ENOG4107R11 Transcriptional regulator HKK60_RS00915 ENOG4107QP3 malate synthase g HKK60_RS00925 ENOG4105BZU Histidine kinase HKK60_RS00950 ENOG4107QX3 carboxylase HKK60_RS00955 ENOG4105C1G acyl-Coa dehydrogenase HKK60_RS00975 ENOG4108TZV Membrane HKK60_RS00985 ENOG4105D6Z AFG1 family ATPase HKK60_RS01000 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKK60_RS01005 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKK60_RS01015 ENOG4105N14 lysine exporter protein LysE YggA HKK60_RS01025 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HKK60_RS01030 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKK60_RS01050 ENOG4108RWI nicotinamidase HKK60_RS01055 ENOG4105WPN DNA integration recombination invertion protein HKK60_RS01070 ENOG4108SKZ Patatin-like phospholipase HKK60_RS01075 ENOG4105CFF transcriptional regulator HKK60_RS01080 ENOG4105C26 Dehydrogenase HKK60_RS01085 ENOG4105C1G acyl-Coa dehydrogenase HKK60_RS01090 ENOG4105E39 Enoyl-CoA hydratase HKK60_RS01095 ENOG4108UKI Enoyl-CoA hydratase HKK60_RS01100 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HKK60_RS01105 ENOG4108ZHJ Organic hydroperoxide resistance protein HKK60_RS01130 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HKK60_RS01140 ENOG4105XJC Two component transcriptional regulator (Winged helix family HKK60_RS01145 ENOG4105EB3 Histidine kinase HKK60_RS01150 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HKK60_RS01160 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HKK60_RS01165 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HKK60_RS01220 ENOG4105D05 Receptor HKK60_RS01260 ENOG4108P8R HKK60_RS01310 ENOG410682P Hypothetical protein (DUF2513) HKK60_RS01340 ENOG4105VUH addiction module killer protein HKK60_RS01375 ENOG4105VDW Csbd family HKK60_RS01385 ENOG4105C31 Tryptophanyl-tRNA synthetase HKK60_RS01410 ENOG4105CSH Transporter HKK60_RS01415 ENOG4105FDR Membrane HKK60_RS01430 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKK60_RS01440 ENOG4105C19 ABC transporter HKK60_RS01460 ENOG4105BZU Histidine kinase HKK60_RS01465 ENOG4108S01 response regulator HKK60_RS01480 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HKK60_RS01495 ENOG4105C02 permease HKK60_RS01515 ENOG4105C0H protease HKK60_RS01530 ENOG4105KCV RNA signal recognition particle 4.5S RNA HKK60_RS01545 ENOG4108KX4 response regulator HKK60_RS01565 ENOG4105DND Transcriptional regulator HKK60_RS01570 ENOG4108W15 Protein of unknown function (DUF1456) HKK60_RS01580 ENOG4105EMU Dehydrogenase HKK60_RS01590 ENOG4105C75 arginyL-tRNA synthetase HKK60_RS01595 ENOG4105W5Q DNA repair protein (RadC HKK60_RS01600 ENOG41068CG regulatoR HKK60_RS01605 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HKK60_RS01615 ENOG4107QKV phosphomannomutase HKK60_RS01625 ENOG4105C08 Histidine kinase HKK60_RS01635 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HKK60_RS01640 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HKK60_RS01655 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HKK60_RS01660 ENOG4105CGK Exodeoxyribonuclease III HKK60_RS01665 ENOG4105EYM Major Facilitator superfamily HKK60_RS01675 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HKK60_RS01680 ENOG4105DR5 peptidase HKK60_RS01685 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HKK60_RS01715 ENOG4107VAM peptidase, m28 HKK60_RS01725 ENOG41063SB peptidase HKK60_RS01730 ENOG4105CN1 protease HKK60_RS01740 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HKK60_RS01745 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HKK60_RS01755 ENOG4105C26 Dehydrogenase HKK60_RS01780 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) HKK60_RS01785 ENOG4107QS1 Cytochrome C Oxidase, Subunit III HKK60_RS01810 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HKK60_RS01820 ENOG4105DHU Bile acid HKK60_RS01830 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HKK60_RS01835 ENOG4107S2Z UPF0761 membrane protein HKK60_RS01850 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HKK60_RS01860 ENOG4107ZVW dihydroneopterin aldolase HKK60_RS01865 ENOG4105CUY Mechanosensitive ion channel HKK60_RS01870 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HKK60_RS01885 ENOG4108Z12 YiaAB two helix domain-containing protein HKK60_RS01895 ENOG4105D5Q Arginine ornithine antiporter HKK60_RS01905 ENOG4106G6Q Transcriptional regulator HKK60_RS01910 ENOG4105DTQ mandelate racemase muconate lactonizing HKK60_RS01925 ENOG4108KPZ tonB-dependent Receptor HKK60_RS01930 ENOG4107R6D beta-lactam binding protein AmpH HKK60_RS01935 ENOG4108UQS dipeptidase HKK60_RS01960 ENOG4105E32 cytoplasmic protein HKK60_RS01970 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HKK60_RS01975 ENOG4105EX9 Membrane HKK60_RS02005 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HKK60_RS02010 ENOG4108YYC ycei family HKK60_RS02025 ENOG4105Q26 Siderophore-interacting protein HKK60_RS02035 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HKK60_RS02165 ENOG4105PGM cation diffusion facilitator family transporter HKK60_RS02170 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter HKK60_RS02185 ENOG4105C5H ABC transporter HKK60_RS02190 ENOG410642W LysR family Transcriptional regulator HKK60_RS02195 ENOG4107S1E Beta-lactamase HKK60_RS02200 ENOG4105F27 Major Facilitator HKK60_RS02205 ENOG41066DG (EAL) domain protein HKK60_RS02215 ENOG4105E4C Lytic transglycosylase catalytic HKK60_RS02240 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HKK60_RS02250 ENOG4105KCV RNA signal recognition particle 4.5S RNA HKK60_RS02255 ENOG4105CHP RNA polymerase HKK60_RS02285 ENOG4108HRK Histidine kinase HKK60_RS02290 ENOG4108VAC response regulator HKK60_RS02310 ENOG4108IG5 Transcriptional regulator HKK60_RS02320 ENOG4105F27 Major Facilitator HKK60_RS02325 ENOG4105C9K Endothelin-converting enzyme 1 HKK60_RS02335 ENOG4105CC0 LysR family Transcriptional regulator HKK60_RS02345 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HKK60_RS02350 ENOG4105EEQ Na H antiporter HKK60_RS02375 ENOG4105ER2 Ompa motb domain protein HKK60_RS02380 ENOG4107RD7 Flagellar Motor Protein, MotA HKK60_RS02400 ENOG4105EW9 transcriptional regulator AsnC family HKK60_RS02405 ENOG4105MWK D-amino acid dehydrogenase, small subunit HKK60_RS02410 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HKK60_RS02420 ENOG4105BZU Histidine kinase HKK60_RS02435 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HKK60_RS02440 ENOG4105I08 Pseudouridine synthase HKK60_RS02445 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HKK60_RS02455 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HKK60_RS02460 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HKK60_RS02475 ENOG4105EJC lysr family transcriptional regulator HKK60_RS02480 ENOG4108I0C methyltransferase HKK60_RS02485 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HKK60_RS02510 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HKK60_RS02515 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKK60_RS02520 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HKK60_RS02525 ENOG4108HSG cytochrome biogenesis protein DipZ HKK60_RS02530 ENOG4105E0X reductase HKK60_RS02535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKK60_RS02540 ENOG4105BZU Histidine kinase HKK60_RS02545 ENOG4105JJR Histidine kinase HKK60_RS02550 ENOG4107EXC regulatoR HKK60_RS02555 ENOG4105CAQ asparagine synthetase HKK60_RS02565 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HKK60_RS02580 ENOG4105C1J atp-dependent rna helicase HKK60_RS02590 ENOG4108RXX maleylacetoacetate isomerase HKK60_RS02595 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HKK60_RS02605 ENOG4105CZX twitching motility protein HKK60_RS02630 ENOG4105C28 cystathionine HKK60_RS02680 ENOG4105C0K Gdp-mannose 4,6-dehydratase HKK60_RS02710 ENOG4105CKK Glycosyl transferase, family 2 HKK60_RS02715 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HKK60_RS02725 ENOG4107QKV phosphomannomutase HKK60_RS02730 ENOG4105C10 Electron transfer flavoprotein HKK60_RS02735 ENOG4105BZJ Electron transfer flavoprotein HKK60_RS02750 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HKK60_RS02790 ENOG4105DHJ ABC, transporter HKK60_RS02805 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HKK60_RS02810 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HKK60_RS02820 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HKK60_RS02830 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HKK60_RS02840 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HKK60_RS02850 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HKK60_RS02860 ENOG4108K5H permease YjgP YjgQ family protein HKK60_RS02870 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HKK60_RS02875 ENOG4105T95 Thiol disulfide interChange protein HKK60_RS02885 ENOG4108ETH Formylglycinamide ribotide synthetase HKK60_RS02895 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HKK60_RS02900 ENOG4107QHF type ii secretion system protein e HKK60_RS02905 ENOG4105D7Q type ii secretion system HKK60_RS02915 ENOG4105WMT general secretion pathway protein h HKK60_RS02925 ENOG41069G9 General secretion pathway protein J HKK60_RS02930 ENOG4105UV2 general secretion pathway protein K HKK60_RS02935 ENOG41090VX general secretion pathway protein L HKK60_RS02940 ENOG410678M general secretion pathway protein M HKK60_RS02950 ENOG4105GVR general secretion pathway protein D HKK60_RS02975 ENOG4105X0I Fimbrial HKK60_RS02995 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HKK60_RS03005 ENOG410802X bacteriophage n4 adsorption protein b HKK60_RS03020 ENOG4105C7N Xanthine uracil vitamin C permease HKK60_RS03030 ENOG4105C5H ABC transporter HKK60_RS03040 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HKK60_RS03060 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HKK60_RS03065 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HKK60_RS03115 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HKK60_RS03120 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HKK60_RS03125 ENOG4107YIM Involved in the transcription termination process (By similarity) HKK60_RS03130 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HKK60_RS03150 ENOG4105CW0 outer membrane usher protein HKK60_RS03185 ENOG4105EXC Acyl-transferase HKK60_RS03195 ENOG4105S2T inner membrane protein YbcI HKK60_RS03230 ENOG4108V6E Cell division protein mraZ HKK60_RS03235 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HKK60_RS03240 ENOG4106932 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HKK60_RS03245 ENOG4105CJN penicillin-binding protein HKK60_RS03250 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HKK60_RS03255 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HKK60_RS03275 ENOG4105DFU Cell wall formation (By similarity) HKK60_RS03280 ENOG4105CPF Cell wall formation (By similarity) HKK60_RS03285 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HKK60_RS03290 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HKK60_RS03295 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HKK60_RS03300 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HKK60_RS03310 ENOG4105DR5 peptidase HKK60_RS03315 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HKK60_RS03320 ENOG4105M6F mutator MutT protein HKK60_RS03330 ENOG4105SYT Methylenetetrahydrofolate reductase HKK60_RS03335 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HKK60_RS03340 ENOG4108HRK Histidine kinase HKK60_RS03345 ENOG4105DY9 regulatoR HKK60_RS03365 ENOG4108Z66 YbaK ebsC protein HKK60_RS03370 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HKK60_RS03380 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HKK60_RS03385 ENOG4108S4H thioesterase Superfamily protein HKK60_RS03390 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HKK60_RS03410 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HKK60_RS03415 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HKK60_RS03425 ENOG4105EXG Transcriptional regulator HKK60_RS03435 ENOG4108RVA ribokinase HKK60_RS03440 ENOG4105D9N nucleoside HKK60_RS03445 ENOG4105CPC Aldo Keto reductase HKK60_RS03455 ENOG4107ENK receptor HKK60_RS03470 ENOG4105CV6 ABC transporter, permease HKK60_RS03475 ENOG4108I0Y (ABC) transporter HKK60_RS03480 ENOG4108UJV acyl-CoA thioesterase i HKK60_RS03490 ENOG4105DHQ Histidine kinase HKK60_RS03500 ENOG41080IJ Diacylglycerol kinase HKK60_RS03505 ENOG4105EE5 Membrane protein terC HKK60_RS03510 ENOG4105F27 Major Facilitator HKK60_RS03515 ENOG4108V0P LemA family HKK60_RS03530 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HKK60_RS03535 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HKK60_RS03545 ENOG4108XC3 NADH ubiquinone oxidoreductase HKK60_RS03555 ENOG4105NWN ApaG protein HKK60_RS03565 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HKK60_RS03570 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HKK60_RS03575 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HKK60_RS03580 ENOG4105DGU Histone deacetylase HKK60_RS03585 ENOG4108WBT adenosyltransferase HKK60_RS03595 ENOG4105D0A hydroxylase HKK60_RS03605 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HKK60_RS03610 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HKK60_RS03630 ENOG4105CX6 glutaminyL-tRNA synthetase HKK60_RS03640 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HKK60_RS03650 ENOG4105NXH GreA GreB family elongation factor HKK60_RS03655 ENOG4105C5Q Transcriptional regulator HKK60_RS03700 ENOG4105C2M dna polymerase I HKK60_RS03715 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HKK60_RS03735 ENOG4105W8H transhydrogenase (subunit alpha HKK60_RS03740 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HKK60_RS03755 ENOG4105CM2 brancheD-chain amino acid aminotransferase HKK60_RS03760 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HKK60_RS03775 ENOG4105CS1 NAD(P)H quinone oxidoreductase HKK60_RS03780 ENOG4107S2Z UPF0761 membrane protein HKK60_RS03785 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HKK60_RS03790 ENOG4105CSR polyphosphate kinase 2 HKK60_RS03800 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HKK60_RS03805 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HKK60_RS03810 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein HKK60_RS03820 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HKK60_RS03830 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HKK60_RS03835 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HKK60_RS03840 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HKK60_RS03845 ENOG4105C3G gtp-binding protein HKK60_RS03850 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS03860 ENOG4105D44 asparaginase HKK60_RS03880 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HKK60_RS03890 ENOG4105PM1 preprotein translocase subunit SecE HKK60_RS03895 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HKK60_RS03900 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HKK60_RS03905 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HKK60_RS03910 ENOG4108VZM 50s ribosomal protein L10 HKK60_RS03915 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HKK60_RS03920 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HKK60_RS03925 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HKK60_RS03930 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HKK60_RS03935 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HKK60_RS03940 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HKK60_RS03945 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HKK60_RS03950 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HKK60_RS03955 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HKK60_RS03960 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HKK60_RS03965 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HKK60_RS03970 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HKK60_RS03975 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HKK60_RS03980 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HKK60_RS03985 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HKK60_RS03990 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HKK60_RS03995 ENOG41083MP 50s ribosomal protein l29 HKK60_RS04000 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HKK60_RS04005 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HKK60_RS04010 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HKK60_RS04015 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HKK60_RS04020 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HKK60_RS04025 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HKK60_RS04030 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HKK60_RS04035 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HKK60_RS04040 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HKK60_RS04045 ENOG41087MT 50S ribosomal protein L30 HKK60_RS04050 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HKK60_RS04055 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HKK60_RS04060 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HKK60_RS04065 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HKK60_RS04070 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HKK60_RS04075 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HKK60_RS04080 ENOG4108ZT0 50S ribosomal protein l17 HKK60_RS04085 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HKK60_RS04095 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HKK60_RS04105 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HKK60_RS04115 ENOG4105CI3 gtp-binding protein typa HKK60_RS04120 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) HKK60_RS04125 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HKK60_RS04130 ENOG4105D3G Pseudouridine synthase HKK60_RS04135 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HKK60_RS04150 ENOG4108K3A Glutathione S-transferase HKK60_RS04160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKK60_RS04165 ENOG4108VW9 Membrane HKK60_RS04170 ENOG4105C94 Transporter HKK60_RS04175 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HKK60_RS04190 ENOG4105ECQ AraC Family Transcriptional Regulator HKK60_RS04195 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS04210 ENOG4105F0N pyrophosphate phospho-hydrolase HKK60_RS04230 ENOG4107ENK receptor HKK60_RS04240 ENOG4108YNN Heme oxygenase HKK60_RS04245 ENOG4105WD1 Membrane HKK60_RS04255 ENOG4108ZZF transport protein (ExbD) HKK60_RS04265 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HKK60_RS04285 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HKK60_RS04290 ENOG4105DFU Cell wall formation (By similarity) HKK60_RS04300 ENOG410841Q phosphoesterase PA-phosphatase related protein HKK60_RS04320 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HKK60_RS04325 ENOG4108V87 frv operon regulatory protein HKK60_RS04330 ENOG4105EYW Ion transport protein HKK60_RS04335 ENOG4105C8Y Acetylornithine aminotransferase HKK60_RS04345 ENOG41090JD Blue (Type 1) copper domain protein HKK60_RS04350 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HKK60_RS04355 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HKK60_RS04360 ENOG4105VCQ rubredoxin HKK60_RS04365 ENOG41063JG Transcriptional regulator HKK60_RS04375 ENOG4105E66 phosphoriboisomerase A HKK60_RS04385 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HKK60_RS04395 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HKK60_RS04405 ENOG4105E07 UPF0149 protein HKK60_RS04410 ENOG4107RAQ aminopeptidase HKK60_RS04415 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HKK60_RS04430 ENOG4105CSA Coproporphyrinogen iii oxidase HKK60_RS04435 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HKK60_RS04440 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HKK60_RS04445 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HKK60_RS04450 ENOG4105DSJ YicC domain protein HKK60_RS04455 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HKK60_RS04465 ENOG4105EM7 Selenocysteine-specific translation elongation factor HKK60_RS04470 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HKK60_RS04475 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HKK60_RS04485 ENOG4108MG3 formate dehydrogenase HKK60_RS04490 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HKK60_RS04505 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HKK60_RS04510 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HKK60_RS04515 ENOG4105KME endoribonuclease L-psp HKK60_RS04520 ENOG4105CB5 ATP-dependent DNA helicase recG HKK60_RS04530 ENOG4105NRA 50s ribosomal protein l31 type b HKK60_RS04535 ENOG4105BZN citrate synthase HKK60_RS04565 ENOG4105EUR Domain-Containing protein HKK60_RS04580 ENOG4108JQC penicillin-binding protein 1A HKK60_RS04605 ENOG4105E4G Type IV pilus HKK60_RS04610 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HKK60_RS04640 ENOG4105CK2 sodium dicarboxylate symporter HKK60_RS04645 ENOG4105CV1 Transketolase (EC 2.2.1.1) HKK60_RS04660 ENOG4105NA0 Transcriptional regulator HKK60_RS04685 ENOG4105EIF outer membrane protein W HKK60_RS04690 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HKK60_RS04705 ENOG4105BZA Phosphoglycerate kinase HKK60_RS04710 ENOG4107XGZ Hydrolase HKK60_RS04715 ENOG4105CA9 Pyruvate kinase HKK60_RS04720 ENOG4107R1Y fructose-bisphosphate aldolase HKK60_RS04730 ENOG4108UVJ appr-1-p processing domain protein HKK60_RS04740 ENOG4107R11 Transcriptional regulator HKK60_RS04755 ENOG4105C1P efflux transporter, rnd family, mfp subunit HKK60_RS04760 ENOG4105BZS acriflavin resistance protein HKK60_RS04770 ENOG4105BZG amino acid carrier protein HKK60_RS04775 ENOG4105C2N RNA methyltransferase TrmH family group 3 HKK60_RS04785 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HKK60_RS04810 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HKK60_RS04815 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HKK60_RS04825 ENOG4107SUD Esterase HKK60_RS04850 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HKK60_RS04865 ENOG4105ETX regulatoR HKK60_RS04870 ENOG4105BZU Histidine kinase HKK60_RS04885 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HKK60_RS04905 ENOG4107QHF type ii secretion system protein e HKK60_RS04910 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HKK60_RS04915 ENOG4107TUY Histidine kinase HKK60_RS04920 ENOG4105CMV Succinyl-CoA synthetase subunit beta HKK60_RS04925 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HKK60_RS04930 ENOG4105C4K Nad synthetase HKK60_RS04940 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HKK60_RS04945 ENOG4105C34 Pseudouridine synthase HKK60_RS04960 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HKK60_RS04970 ENOG4105BZP glycoside hydrolase 15-related HKK60_RS04975 ENOG4108K4C ec 3.1.3.12 HKK60_RS04980 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS04995 ENOG4105C7K acetolactate synthase HKK60_RS05015 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKK60_RS05025 ENOG4105E0F Histidine kinase HKK60_RS05030 ENOG4107EXC regulatoR HKK60_RS05040 ENOG4105CKD glutathione-regulated potassium-efflux system protein HKK60_RS05065 ENOG4105C5H ABC transporter HKK60_RS05070 ENOG4105ETT transcriptional Regulator, LysR family HKK60_RS05095 ENOG4105C9M aspartyl-trna synthetase HKK60_RS05115 ENOG4105CDY transcriptional regulatory protein HKK60_RS05120 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HKK60_RS05125 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HKK60_RS05130 ENOG4105DFH Transport of potassium into the cell (By similarity) HKK60_RS05135 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HKK60_RS05140 ENOG4107YD3 Thioesterase HKK60_RS05145 ENOG4105E02 MotA TolQ exbB proton channel HKK60_RS05150 ENOG4105M8F Biopolymer transport protein exbD tolR HKK60_RS05160 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HKK60_RS05165 ENOG4105KCK Peptidoglycan-associated lipoprotein HKK60_RS05175 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HKK60_RS05180 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HKK60_RS05475 ENOG4105C9U ATP-dependent DNA helicase RecQ HKK60_RS05485 ENOG4105CQ7 ATP-dependent helicase HKK60_RS05495 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HKK60_RS05510 ENOG4108SHN Glycosyl transferase, family 2 HKK60_RS05515 ENOG4105BZ4 penicillin-binding protein HKK60_RS05525 ENOG4105DVT helicase HKK60_RS05530 ENOG41072GX Peptidase M22 Glycoprotease HKK60_RS05540 ENOG4105D7Z glutathione synthase HKK60_RS05545 ENOG4108UNF response regulator HKK60_RS05550 ENOG4105M3Z response regulator HKK60_RS05560 ENOG4105C8Q Methyl-accepting chemotaxis HKK60_RS05580 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HKK60_RS05590 ENOG4107RK2 ADP-ribose diphosphatase NudE HKK60_RS05595 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HKK60_RS05600 ENOG4105DXN mazG family HKK60_RS05605 ENOG4105KK4 UPF0060 membrane protein HKK60_RS05615 ENOG4107QX8 SPFH domain, Band 7 family protein HKK60_RS05625 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HKK60_RS05630 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HKK60_RS05640 ENOG4105CC0 LysR family Transcriptional regulator HKK60_RS05645 ENOG4105CHR reductase HKK60_RS05670 ENOG4107QPN acyl-Coa dehydrogenase HKK60_RS05680 ENOG4108IG5 Transcriptional regulator HKK60_RS05685 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS05695 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HKK60_RS05700 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HKK60_RS05720 ENOG4108UT2 hemolysin iii HKK60_RS05725 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HKK60_RS05730 ENOG4105DR5 peptidase HKK60_RS05735 ENOG4106TYC homoserine o-acetyltransferase (EC 2.3.1.31) HKK60_RS05740 ENOG4105C28 cystathionine HKK60_RS05745 ENOG4105CFH Aspartokinase HKK60_RS05750 ENOG41088PD hydrolase HKK60_RS05755 ENOG4105EJQ L-serine dehydratase HKK60_RS05770 ENOG4105DS1 cytochrome b561 HKK60_RS05780 ENOG4105BZU Histidine kinase HKK60_RS05785 ENOG4105BZU Histidine kinase HKK60_RS05790 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKK60_RS05805 ENOG4105D49 3-dehydroquinate synthase HKK60_RS05810 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HKK60_RS05825 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HKK60_RS05830 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) HKK60_RS05845 ENOG4108JU7 Transcriptional regulator HKK60_RS05850 ENOG4105CR4 methylisocitrate lyase HKK60_RS05855 ENOG4105BZN citrate synthase HKK60_RS05860 ENOG4108I0Z Aconitate hydratase HKK60_RS05865 ENOG4105YAJ CopG Arc MetJ HKK60_RS05875 ENOG4105C7F AcnD-accessory protein PrpF HKK60_RS05880 ENOG4105DXD 2-methylcitrate dehydratase HKK60_RS05885 ENOG4105DN3 alpha-2-macroglobulin domain protein HKK60_RS05890 ENOG4108JQB penicillin-binding protein 1C HKK60_RS05910 ENOG4105M3Z response regulator HKK60_RS05920 ENOG4107QJR hflk protein HKK60_RS05925 ENOG4105EPW hflc protein HKK60_RS05935 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HKK60_RS05945 ENOG4105DR5 peptidase HKK60_RS05950 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HKK60_RS05955 ENOG4105C8Q Methyl-accepting chemotaxis HKK60_RS05985 ENOG4106AXJ AraC family transcriptional regulator HKK60_RS05990 ENOG4105C85 amino acid HKK60_RS06000 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HKK60_RS06005 ENOG4105C2C drug resistance transporter, Bcr CflA HKK60_RS06025 ENOG4105DIJ Phosphoethanolamine transferase HKK60_RS06040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKK60_RS06045 ENOG4105EB3 Histidine kinase HKK60_RS06060 ENOG4105VCD cytoplasmic protein HKK60_RS06065 ENOG4105D22 carbon starvation protein HKK60_RS06070 ENOG4105EUB pirin domain protein HKK60_RS06080 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HKK60_RS06085 ENOG4105EUB pirin domain protein HKK60_RS06095 ENOG4105EMN RNA polymerase sigma factor HKK60_RS06105 ENOG4105C0H protease HKK60_RS06110 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HKK60_RS06115 ENOG4105C3F Signal peptidase i HKK60_RS06125 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HKK60_RS06130 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HKK60_RS06135 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HKK60_RS06140 ENOG4105EFQ Two component transcriptional regulator (Winged helix family HKK60_RS06145 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HKK60_RS06155 ENOG4107ZXU DSBA oxidoreductase HKK60_RS06160 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HKK60_RS06165 ENOG4108UGV hypoxanthine phosphoribosyltransferase HKK60_RS06170 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HKK60_RS06175 ENOG4105VEQ Cold shock protein HKK60_RS06180 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HKK60_RS06195 ENOG4107QRT dEAD DEAH box helicase HKK60_RS06200 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HKK60_RS06210 ENOG4105CSU acyl-Coa dehydrogenase HKK60_RS06225 ENOG4105CHU acetyl-coa acetyltransferase HKK60_RS06245 ENOG4107RZC phospholipase d HKK60_RS06255 ENOG4108VKG metal-dependent hydrolase HKK60_RS06260 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HKK60_RS06265 ENOG4105KSC Transcriptional regulator, TraR DksA family HKK60_RS06305 ENOG4105CFG Acts as a chaperone (By similarity) HKK60_RS06310 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HKK60_RS06345 ENOG4105M4H endoribonuclease L-psp HKK60_RS06350 ENOG4108R3D Electron transport complex HKK60_RS06360 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HKK60_RS06370 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HKK60_RS06375 ENOG4105FQP Beta-lactamase HKK60_RS06415 ENOG4107QR8 Thioredoxin HKK60_RS06425 ENOG4105C8T Leucyl-tRNA synthetase HKK60_RS06440 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HKK60_RS06450 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HKK60_RS06460 ENOG4105D5Q Arginine ornithine antiporter HKK60_RS06465 ENOG4105D05 Receptor HKK60_RS06475 ENOG4105MPN Membrane HKK60_RS06480 ENOG4108Z03 MAF-like protein HKK60_RS06485 ENOG4105C03 ribonuclease HKK60_RS06495 ENOG4105D1U peptidase U62 modulator of DNA gyrase HKK60_RS06500 ENOG4105N42 UPF0307 protein HKK60_RS06505 ENOG4105CMS peptidase U62, modulator of DNA gyrase HKK60_RS06515 ENOG4105CTB Polyprenyl synthetase HKK60_RS06520 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HKK60_RS06525 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HKK60_RS06545 ENOG4105K4H Nlp p60 protein HKK60_RS06550 ENOG4105K4H Nlp p60 protein HKK60_RS06555 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HKK60_RS06565 ENOG4105MWK D-amino acid dehydrogenase, small subunit HKK60_RS06575 ENOG4107RT3 EamA-like transporter family HKK60_RS06605 ENOG4105C9K Endothelin-converting enzyme 1 HKK60_RS06610 ENOG4105C01 Dihydroxy-acid dehydratase HKK60_RS06615 ENOG4105D05 Receptor HKK60_RS06620 ENOG4105D05 Receptor HKK60_RS06640 ENOG4105DHP deoxycytidine triphosphate deaminase HKK60_RS06660 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HKK60_RS06670 ENOG4108RRZ Transcription elongation factor GreB HKK60_RS06675 ENOG4105D7A ATP-binding protein HKK60_RS06690 ENOG4105DJ4 phosphatidylserine decarboxylase HKK60_RS06700 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HKK60_RS06705 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HKK60_RS06710 ENOG4105C5I Dehydrogenase HKK60_RS06715 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HKK60_RS06730 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HKK60_RS06735 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HKK60_RS06755 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HKK60_RS06765 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HKK60_RS06770 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HKK60_RS06775 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HKK60_RS06780 ENOG4105CMR udp-glucose 4-epimerase HKK60_RS06785 ENOG4107BJW polysaccharide deacetylase HKK60_RS06790 ENOG4108PQP glycosyl transferase group 1 HKK60_RS06795 ENOG4105E68 Sulfatase HKK60_RS06805 ENOG4105CP7 Triose-phosphate isomerase HKK60_RS06820 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HKK60_RS06825 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKK60_RS06830 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HKK60_RS06835 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKK60_RS06840 ENOG4105GKE subunit e HKK60_RS06850 ENOG4107R0R NADH dehydrogenase subunit g HKK60_RS06860 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKK60_RS06865 ENOG4105DF2 NADH dehydrogenase subunit j HKK60_RS06870 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKK60_RS06875 ENOG4105D65 subunit l HKK60_RS06880 ENOG4105C8S subunit m HKK60_RS06885 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HKK60_RS06900 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HKK60_RS06905 ENOG4105CHV Transcription elongation factor NusA HKK60_RS06910 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HKK60_RS06915 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HKK60_RS06925 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HKK60_RS06930 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HKK60_RS06940 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HKK60_RS06960 ENOG4105C22 threonyL-tRNA synthetase HKK60_RS06965 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HKK60_RS06970 ENOG41082NX 50s ribosomal protein l35 HKK60_RS06975 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HKK60_RS06980 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HKK60_RS06985 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HKK60_RS06990 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HKK60_RS07060 ENOG4105CDU Replicative dna helicase HKK60_RS07130 ENOG410829K Lysine exporter protein (Lyse ygga) HKK60_RS07175 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HKK60_RS07185 ENOG4105CSU acyl-Coa dehydrogenase HKK60_RS07210 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HKK60_RS07215 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HKK60_RS07240 ENOG4107ZSV Receptor HKK60_RS07260 ENOG4105E6M Sulphatase-modifying factor protein HKK60_RS07270 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HKK60_RS07275 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HKK60_RS07280 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HKK60_RS07285 ENOG4105K8N protein family UPF0079, ATPase HKK60_RS07290 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HKK60_RS07295 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HKK60_RS07315 ENOG4105CHR reductase HKK60_RS07320 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HKK60_RS07325 ENOG4105D0M Protease HtpX homolog HKK60_RS07345 ENOG4105BZU Histidine kinase HKK60_RS07350 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HKK60_RS07355 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HKK60_RS07360 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HKK60_RS07365 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HKK60_RS07370 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HKK60_RS07385 ENOG4105CD3 dihydroorotase HKK60_RS07390 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HKK60_RS07405 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HKK60_RS07410 ENOG4105C8N cysteinyl-tRNA synthetase HKK60_RS07420 ENOG4105DBV ornithine carbamoyltransferase HKK60_RS07425 ENOG4105CDH Citrulline--aspartate ligase HKK60_RS07435 ENOG4105CAS nag kinase HKK60_RS07445 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HKK60_RS07450 ENOG4105CH7 arginosuccinase HKK60_RS07465 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HKK60_RS07475 ENOG4105CND Glycosyl transferase, family 2 HKK60_RS07480 ENOG4107BJW polysaccharide deacetylase HKK60_RS07510 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HKK60_RS07515 ENOG4105C4M (Ubiquinol oxidase) subunit I HKK60_RS07520 ENOG4108JJ9 ABC, transporter HKK60_RS07525 ENOG4108JJ8 (ABC) transporter HKK60_RS07535 ENOG4105DWV Homoserine O-trans-acetylase HKK60_RS07540 ENOG4108M1T Cytochrome c-type biogenesis protein HKK60_RS07545 ENOG4105KWW Biogenesis protein HKK60_RS07555 ENOG4105DA4 cytochrome c-type biogenesis protein HKK60_RS07560 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HKK60_RS07570 ENOG41060IM Heme exporter protein HKK60_RS07575 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HKK60_RS07580 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HKK60_RS07585 ENOG4105CHM Aminotransferase HKK60_RS07605 ENOG4105E5M Multidrug resistance protein D HKK60_RS07615 ENOG4105FE9 pseudouridine synthase HKK60_RS07620 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HKK60_RS07625 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HKK60_RS07630 ENOG4105K9H YciI-like protein HKK60_RS07635 ENOG4105M85 Bola protein HKK60_RS07665 ENOG4105DRS transport system, permease HKK60_RS07680 ENOG4105C03 ribonuclease HKK60_RS07685 ENOG4105EI2 Pseudouridine synthase HKK60_RS07690 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) HKK60_RS07700 ENOG41090A4 Pterin carbinolamine dehydratase HKK60_RS07705 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HKK60_RS07725 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKK60_RS07735 ENOG4105DUX Transporter HKK60_RS07760 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HKK60_RS07770 ENOG4105DGW oligopeptidase A HKK60_RS07780 ENOG4105DP0 ferredoxin-NADP reductase HKK60_RS07790 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HKK60_RS07795 ENOG4108KPJ rna polymerase sigma factor HKK60_RS07800 ENOG4107GFK fumarate HKK60_RS07810 ENOG4108TGY Glutathione S-transferase HKK60_RS07820 ENOG4105HDD phospholipase HKK60_RS07830 ENOG4105VEQ Cold shock protein HKK60_RS07845 ENOG4105CUZ uba thif-type nad fad binding protein HKK60_RS07850 ENOG4105F8V Hydrolase, tatD family HKK60_RS07875 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HKK60_RS07890 ENOG4105CDU Replicative dna helicase HKK60_RS07900 ENOG4105DGI Alkaline phosphatase HKK60_RS07920 ENOG4105C7S Dehydrogenase HKK60_RS07925 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HKK60_RS07935 ENOG4105EZE Cupin 4 family protein HKK60_RS07940 ENOG4107QTF adenylosuccinate lyase HKK60_RS07945 ENOG4105C9Q fumarate hydratase class II HKK60_RS07970 ENOG4105CZV ABC transporter HKK60_RS07975 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HKK60_RS07985 ENOG4108V06 Glutathione peroxidase HKK60_RS07990 ENOG4108V1T peptidylprolyl cis-trans isomerase HKK60_RS07995 ENOG4105C6Y Udp-glucose 6-dehydrogenase HKK60_RS08020 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKK60_RS08025 ENOG4105C1G acyl-Coa dehydrogenase HKK60_RS08040 ENOG4105BZS acriflavin resistance protein HKK60_RS08045 ENOG4105C1P efflux transporter, rnd family, mfp subunit HKK60_RS08055 ENOG4105C7I Dehydrogenase HKK60_RS08060 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HKK60_RS08080 ENOG4105CJB Exodeoxyribonuclease I HKK60_RS08085 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HKK60_RS08090 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HKK60_RS08100 ENOG41077A9 carbonic anhydrase HKK60_RS08120 ENOG4105C5S asparaginyl-tRNA synthetase HKK60_RS08125 ENOG4108Z4V iron-sulfur cluster assembly HKK60_RS08130 ENOG4106611 bacteriocin immunity HKK60_RS08135 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HKK60_RS08140 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HKK60_RS08145 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HKK60_RS08155 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HKK60_RS08160 ENOG4105CIH Imidazole acetol-phosphate transaminase HKK60_RS08165 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HKK60_RS08175 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HKK60_RS08185 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HKK60_RS08190 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKK60_RS08195 ENOG4105DZG Dehydrogenase HKK60_RS08200 ENOG4105CPQ Dehydrogenase HKK60_RS08310 ENOG4105CGP Urocanate hydratase HKK60_RS08325 ENOG4105CI2 imidazolone-5-propionate hydrolase HKK60_RS08370 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HKK60_RS08380 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HKK60_RS08395 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HKK60_RS08405 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HKK60_RS08410 ENOG4105CC0 LysR family Transcriptional regulator HKK60_RS08425 ENOG41088T4 Helicase IV HKK60_RS08435 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HKK60_RS08440 ENOG4105KVH Transcriptional regulator HKK60_RS08460 ENOG4105E0K tonB-dependent siderophore receptor HKK60_RS08475 ENOG4105CQZ Histidine kinase HKK60_RS08510 ENOG4108Z4X TRANSCRIPTIONal HKK60_RS08515 ENOG4105F27 Major Facilitator HKK60_RS08550 ENOG4105CMA conjugation trbi family protein HKK60_RS08570 ENOG4106E4H Type IV secretory pathway VirB3 family protein HKK60_RS08650 ENOG4105K5X acetyltransferase HKK60_RS08655 ENOG4105DYS nad(p)h dehydrogenase (quinone) HKK60_RS08660 ENOG4105KVH Transcriptional regulator HKK60_RS08665 ENOG4108Z6B deaminase HKK60_RS08670 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HKK60_RS08680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKK60_RS08700 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HKK60_RS08720 ENOG4107QJQ Mate efflux family protein HKK60_RS08725 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HKK60_RS08740 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HKK60_RS08745 ENOG4105M0Y HKK60_RS08750 ENOG41067S9 phage shock protein C, PspC HKK60_RS08765 ENOG4105BZM domain protein HKK60_RS08770 ENOG4105BZU Histidine kinase HKK60_RS08795 ENOG4107SDU Methyl-accepting chemotaxis HKK60_RS08855 ENOG4105W1Y Transcriptional regulator HKK60_RS08865 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HKK60_RS08870 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HKK60_RS08880 ENOG4105D5Q Arginine ornithine antiporter HKK60_RS08885 ENOG4105CXN decarboxylase HKK60_RS08920 ENOG4108SF5 RNA Polymerase HKK60_RS08935 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HKK60_RS08940 ENOG4105DFA alanine racemase domain protein HKK60_RS08945 ENOG4105CSW GntR family transcriptional regulator HKK60_RS08955 ENOG4105C0B DNA polymerase III (alpha subunit) HKK60_RS08980 ENOG4105JQN Transcriptional regulator HKK60_RS09000 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HKK60_RS09005 ENOG4105JQN Transcriptional regulator HKK60_RS09010 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKK60_RS09035 ENOG4108302 MgtC SapB transporter HKK60_RS09040 ENOG4105DAA L-lactate HKK60_RS09045 ENOG41073TP transcriptional regulator HKK60_RS09050 ENOG4105DMF Dehydrogenase HKK60_RS09055 ENOG4105CXG d-lactate dehydrogenase HKK60_RS09085 ENOG4107RNH Outer membrane receptor FepA HKK60_RS09110 ENOG4107NQ8 LysR family Transcriptional regulator HKK60_RS09120 ENOG4105CPN adenine deaminase HKK60_RS09125 ENOG4105JQN Transcriptional regulator HKK60_RS09130 ENOG4105EQ0 Major Facilitator superfamily HKK60_RS09135 ENOG4105WH1 Two component transcriptional regulator luxr family HKK60_RS09140 ENOG4105BZU Histidine kinase HKK60_RS09150 ENOG4107XVH Transcriptional regulator HKK60_RS09155 ENOG4105CHJ isochorismatase hydrolase HKK60_RS09165 ENOG4105CI2 imidazolone-5-propionate hydrolase HKK60_RS09175 ENOG4107SFI Major Facilitator superfamily HKK60_RS09260 ENOG4105EUR Domain-Containing protein HKK60_RS09260 ENOG4105EUR Domain-Containing protein HKK60_RS09265 ENOG4105UYK outer membrane protein a HKK60_RS09275 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKK60_RS09295 ENOG4105GAV receptor HKK60_RS09310 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HKK60_RS09315 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HKK60_RS09340 ENOG4105C94 Transporter HKK60_RS09345 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS09355 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKK60_RS09360 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKK60_RS09375 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HKK60_RS09380 ENOG4105KST dependent repressor HKK60_RS09395 ENOG4105EJ2 Transcriptional regulator HKK60_RS09410 ENOG4105WAP TPR repeat-containing protein HKK60_RS09420 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKK60_RS09435 ENOG4105DYW oxidoreductase HKK60_RS09440 ENOG4105EYF MMPL domain protein HKK60_RS09450 ENOG4105E4F Isochorismate synthase HKK60_RS09455 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HKK60_RS09460 ENOG4105WQI isochorismatase HKK60_RS09465 ENOG4105WQI isochorismatase HKK60_RS09470 ENOG4105C0W non-ribosomal peptide synthetase HKK60_RS09475 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HKK60_RS09505 ENOG4107QKZ Ompa motb domain protein HKK60_RS09525 ENOG4105DIJ Phosphoethanolamine transferase HKK60_RS09530 ENOG41080IJ Diacylglycerol kinase HKK60_RS09535 ENOG4106F60 Histidine kinase HKK60_RS09555 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKK60_RS09560 ENOG4105Y49 secretion protein, HlyD family HKK60_RS09575 ENOG4105R1U AraC Family Transcriptional Regulator HKK60_RS09580 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HKK60_RS09615 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HKK60_RS09620 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HKK60_RS09625 ENOG4105CVM Molybdenum cofactor synthesis domain protein HKK60_RS09635 ENOG4108ZAF Molybdopterin HKK60_RS09655 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HKK60_RS09660 ENOG4105E0C molybdate abc transporter HKK60_RS09675 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HKK60_RS09680 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HKK60_RS09685 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HKK60_RS09690 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HKK60_RS09725 ENOG4105EW9 transcriptional regulator AsnC family HKK60_RS09735 ENOG410904A RNA polymerase HKK60_RS09755 ENOG4108VAU general secretion pathway protein G HKK60_RS09775 ENOG4105GVR general secretion pathway protein D HKK60_RS09780 ENOG4107QHF type ii secretion system protein e HKK60_RS09785 ENOG4105D7Q type ii secretion system HKK60_RS09790 ENOG4108UPW ABC transporter HKK60_RS09805 ENOG4105X5Z General secretion pathway protein I HKK60_RS09810 ENOG4105VWV general secretion pathway protein h HKK60_RS09830 ENOG4105E02 MotA TolQ exbB proton channel HKK60_RS09835 ENOG4105SG9 biopolymer transport protein, ExbD HKK60_RS09860 ENOG4105CHJ isochorismatase hydrolase HKK60_RS09865 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HKK60_RS09875 ENOG4105CHJ isochorismatase hydrolase HKK60_RS09880 ENOG4105EUB pirin domain protein HKK60_RS09885 ENOG4105JQN Transcriptional regulator HKK60_RS09900 ENOG4105CNM Receptor HKK60_RS09920 ENOG4105BZU Histidine kinase HKK60_RS09940 ENOG4105CSH Transporter HKK60_RS09955 ENOG4105CWX Alpha-1,2-mannosidase HKK60_RS09960 ENOG4105DHQ Histidine kinase HKK60_RS09965 ENOG4105XJC Two component transcriptional regulator (Winged helix family HKK60_RS09985 ENOG4105CHR reductase HKK60_RS09990 ENOG4105EQ2 LysR family Transcriptional regulator HKK60_RS09995 ENOG4105GR3 Histidine kinase HKK60_RS10010 ENOG4105JDN Copper resistance protein HKK60_RS10030 ENOG4105CV8 reductase HKK60_RS10035 ENOG4105HEI LysR family (Transcriptional regulator HKK60_RS10075 ENOG4105C57 major facilitator superfamily HKK60_RS10100 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HKK60_RS10150 ENOG4108ZXC Two component transcriptional regulator, luxr family HKK60_RS10155 ENOG4105BZU Histidine kinase HKK60_RS10165 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HKK60_RS10185 ENOG4105BZS acriflavin resistance protein HKK60_RS10195 ENOG4105GR3 Histidine kinase HKK60_RS10220 ENOG4105T0Z Conserved Protein HKK60_RS10230 ENOG4105EB3 Histidine kinase HKK60_RS10235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKK60_RS10245 ENOG4105DJY efflux transporter, rnd family, mfp subunit HKK60_RS10260 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HKK60_RS10270 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HKK60_RS10275 ENOG4105CG3 alpha amylase, catalytic region HKK60_RS10280 ENOG4105CGK Exodeoxyribonuclease III HKK60_RS10285 ENOG4105BZU Histidine kinase HKK60_RS10360 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HKK60_RS10405 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HKK60_RS10435 ENOG4105D7K pfkb domain protein HKK60_RS10450 ENOG4105DPW Major facilitator superfamily MFS_1 HKK60_RS10455 ENOG4105EY3 heparinase II III family protein HKK60_RS10470 ENOG4107YCY Transcriptional regulator HKK60_RS10485 ENOG4105CEY Amp-dependent synthetase and ligase HKK60_RS10495 ENOG41062D9 Histidine kinase HKK60_RS10520 ENOG4107R6D beta-lactam binding protein AmpH HKK60_RS10545 ENOG4108UZX fmn reductase HKK60_RS10550 ENOG4105DZ2 Transcriptional regulator HKK60_RS10555 ENOG4105DAE Methylenetetrahydrofolate reductase HKK60_RS10580 ENOG4105F04 LysR family Transcriptional regulator HKK60_RS10585 ENOG4105C7F AcnD-accessory protein PrpF HKK60_RS10600 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HKK60_RS10615 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HKK60_RS10620 ENOG4105ETE Transcriptional regulator (LacI family HKK60_RS10625 ENOG4105EDR glucose galactose transporter HKK60_RS10650 ENOG4105KVH Transcriptional regulator HKK60_RS10665 ENOG4105DM4 PTS System HKK60_RS10670 ENOG4105DE4 1-phosphofructokinase HKK60_RS10675 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HKK60_RS10680 ENOG4105ETE Transcriptional regulator (LacI family HKK60_RS10710 ENOG4105E2A Dehydrogenase HKK60_RS10755 ENOG4108N8X transition metal ion binding HKK60_RS10760 ENOG4105WEF catalase HKK60_RS10785 ENOG4108Z9Z response to DNA damage stimulus HKK60_RS10795 ENOG4105DQE DNA ligase HKK60_RS10830 ENOG4107FW0 short-chain dehydrogenase reductase HKK60_RS10845 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HKK60_RS10850 ENOG4108KPJ rna polymerase sigma factor HKK60_RS10870 ENOG4105EQ2 LysR family Transcriptional regulator HKK60_RS10880 ENOG4108ZHJ Organic hydroperoxide resistance protein HKK60_RS10890 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HKK60_RS10895 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HKK60_RS10900 ENOG4105C7W Xanthine dehydrogenase HKK60_RS10905 ENOG4105XRQ Xanthine dehydrogenase accessory factor HKK60_RS10940 ENOG4105EMU Dehydrogenase HKK60_RS11005 ENOG4105BZU Histidine kinase HKK60_RS11010 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HKK60_RS11020 ENOG4105KAV tspo and mbr like protein HKK60_RS11030 ENOG4105BZU Histidine kinase HKK60_RS11055 ENOG4105EMN RNA polymerase sigma factor HKK60_RS11080 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HKK60_RS11095 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HKK60_RS11125 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HKK60_RS11135 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HKK60_RS11140 ENOG4105EHG Permease protein HKK60_RS11145 ENOG4107R4I Periplasmic binding protein HKK60_RS11155 ENOG4105NIV Esterase HKK60_RS11175 ENOG4105D1H recombination factor protein RarA HKK60_RS11190 ENOG4105CNU cell division protein FtsK HKK60_RS11195 ENOG4105C3M thioredoxin reductase HKK60_RS11230 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKK60_RS11240 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HKK60_RS11255 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HKK60_RS11260 ENOG41075W9 High frequency lysogenization protein HflD homolog HKK60_RS11280 ENOG4105BZU Histidine kinase HKK60_RS11290 ENOG4105BZU Histidine kinase HKK60_RS11295 ENOG4105BZU Histidine kinase HKK60_RS11320 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HKK60_RS11325 ENOG4108ZC9 flagellar basal-body rod protein flgc HKK60_RS11335 ENOG4105BZE flagellar hook protein, FlgE HKK60_RS11340 ENOG4108KPB Flagellar basal-body rod protein FlgF HKK60_RS11345 ENOG4105CGA flagellar basal-body rod protein FlgG HKK60_RS11350 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HKK60_RS11360 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HKK60_RS11365 ENOG4105E1Q flagellar hook-associated protein HKK60_RS11390 ENOG4105DTS flagellar hook-associated HKK60_RS11395 ENOG4105MQ3 flagellar protein FliS HKK60_RS11410 ENOG4105WH1 Two component transcriptional regulator luxr family HKK60_RS11415 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKK60_RS11440 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HKK60_RS11445 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HKK60_RS11450 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HKK60_RS11460 ENOG4108JIR Flagellum-specific ATP synthase HKK60_RS11480 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HKK60_RS11485 ENOG4105DD5 Flagellar motor switch protein HKK60_RS11490 ENOG4105K0P flagellar biosynthesis protein HKK60_RS11495 ENOG4105CN7 Flagellar biosynthetic protein FliP HKK60_RS11500 ENOG4105VS8 Flagellar biosynthetic protein fliq HKK60_RS11505 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HKK60_RS11510 ENOG4105BZU Histidine kinase HKK60_RS11520 ENOG4105D00 flagellar biosynthetic protein flhB HKK60_RS11525 ENOG4105D7B Flagellar biosynthesis protein flha HKK60_RS11530 ENOG4105FZW flagellar biosynthesis regulator FlhF HKK60_RS11540 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKK60_RS11545 ENOG4108VYJ response regulator receiver protein HKK60_RS11550 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HKK60_RS11560 ENOG4105E14 MotA TolQ exbB proton channel HKK60_RS11565 ENOG4105ER2 Ompa motb domain protein HKK60_RS11575 ENOG4108V3W Chemotaxis protein, CheW HKK60_RS11585 ENOG4108VYJ response regulator receiver protein HKK60_RS11590 ENOG4105CBS Chea signal transduction histidine kinase HKK60_RS11595 ENOG4105C8Q Methyl-accepting chemotaxis HKK60_RS11600 ENOG4108REP Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HKK60_RS11605 ENOG4108V3W Chemotaxis protein, CheW HKK60_RS11615 ENOG4105C8Q Methyl-accepting chemotaxis HKK60_RS11620 ENOG4105C8Q Methyl-accepting chemotaxis HKK60_RS11625 ENOG4105BZU Histidine kinase HKK60_RS11630 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HKK60_RS11635 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HKK60_RS11650 ENOG4107QIJ Aconitate hydratase 2 HKK60_RS11670 ENOG4107QM5 aconitate hydratase HKK60_RS11675 ENOG4105C94 Transporter HKK60_RS11680 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HKK60_RS11685 ENOG4105C26 Dehydrogenase HKK60_RS11690 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HKK60_RS11695 ENOG4105CEY Amp-dependent synthetase and ligase HKK60_RS11700 ENOG4105E39 Enoyl-CoA hydratase HKK60_RS11705 ENOG4105BZU Histidine kinase HKK60_RS11715 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HKK60_RS11725 ENOG4105C7K acetolactate synthase HKK60_RS11730 ENOG4105C26 Dehydrogenase HKK60_RS11745 ENOG4105DY9 regulatoR HKK60_RS11755 ENOG4105EDV vault protein HKK60_RS11760 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HKK60_RS11775 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HKK60_RS11780 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HKK60_RS11785 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HKK60_RS11790 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HKK60_RS11805 ENOG4105DYS nad(p)h dehydrogenase (quinone) HKK60_RS11820 ENOG4105CE1 Ferrous iron transport protein b HKK60_RS11840 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HKK60_RS11850 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HKK60_RS11865 ENOG4105BZS acriflavin resistance protein HKK60_RS11870 ENOG4105C1P efflux transporter, rnd family, mfp subunit HKK60_RS11875 ENOG4105E3W Two component transcriptional regulator (Winged helix family HKK60_RS11880 ENOG4105EB3 Histidine kinase HKK60_RS11895 ENOG4105CQB FAD linked oxidase domain protein HKK60_RS11900 ENOG4108JQ1 Dehydrogenase HKK60_RS11910 ENOG4105CUB amino acid HKK60_RS11915 ENOG4105CUB amino acid HKK60_RS11930 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HKK60_RS11935 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HKK60_RS11940 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HKK60_RS11955 ENOG4105D7K pfkb domain protein HKK60_RS11965 ENOG4105ETE Transcriptional regulator (LacI family HKK60_RS11970 ENOG4105CWX Alpha-1,2-mannosidase HKK60_RS11995 ENOG4107RNH Outer membrane receptor FepA HKK60_RS12005 ENOG4106N3A copper homeostasis protein cutc HKK60_RS12030 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HKK60_RS12035 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HKK60_RS12040 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HKK60_RS12045 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HKK60_RS12050 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HKK60_RS12055 ENOG4105CIH Imidazole acetol-phosphate transaminase HKK60_RS12060 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HKK60_RS12065 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HKK60_RS12075 ENOG4105CUT histidyl-tRNA synthetase HKK60_RS12080 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HKK60_RS12085 ENOG4105D98 threonine synthase HKK60_RS12095 ENOG4105CFH Aspartokinase HKK60_RS12135 ENOG41080HT Transcriptional regulator, arsr family HKK60_RS12140 ENOG4105CQZ Histidine kinase HKK60_RS12145 ENOG4107Z5C methylesterase HKK60_RS12150 ENOG4105BZU Histidine kinase HKK60_RS12155 ENOG4105BZU Histidine kinase HKK60_RS12165 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HKK60_RS12205 ENOG4105C26 Dehydrogenase HKK60_RS12210 ENOG4107ZQV short-chain dehydrogenase reductase HKK60_RS12225 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HKK60_RS12230 ENOG4105D4A Cell wall formation (By similarity) HKK60_RS12235 ENOG4108JHT EamA-like transporter family HKK60_RS12250 ENOG4108RZE Tetr family transcriptional regulator HKK60_RS12270 ENOG4105WZW rhodanese family HKK60_RS12280 ENOG4105UBK short-chain dehydrogenase reductase HKK60_RS12285 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKK60_RS12290 ENOG4105HEI LysR family (Transcriptional regulator HKK60_RS12295 ENOG41066DG (EAL) domain protein HKK60_RS12300 ENOG4108IG5 Transcriptional regulator HKK60_RS12320 ENOG4105EAB amino acid AbC transporter HKK60_RS12325 ENOG4105CDA abc transporter atp-binding protein HKK60_RS12330 ENOG4108MJ3 acetyltransferase HKK60_RS12335 ENOG4105CH2 amidohydrolase HKK60_RS12345 ENOG4105DEN Luciferase family HKK60_RS12355 ENOG4108UZX fmn reductase HKK60_RS12360 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS12390 ENOG4105CCI Myosin-Cross-Reactive Antigen HKK60_RS12405 ENOG41082BM Transcriptional regulator, arsr family HKK60_RS12430 ENOG4105DTD Dehydrogenase HKK60_RS12460 ENOG4105CC0 LysR family Transcriptional regulator HKK60_RS12485 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HKK60_RS12490 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HKK60_RS12500 ENOG4105CKD glutathione-regulated potassium-efflux system protein HKK60_RS12505 ENOG4105D06 uba thif-type nad fad binding protein HKK60_RS12525 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HKK60_RS12530 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HKK60_RS12540 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HKK60_RS12540 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HKK60_RS12545 ENOG4105RQ9 TPR repeat-containing protein HKK60_RS12550 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HKK60_RS12555 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HKK60_RS12570 ENOG4105CHU acetyl-coa acetyltransferase HKK60_RS12575 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HKK60_RS12585 ENOG4105ESV Glycosyl transferase, family 4 HKK60_RS12590 ENOG4105CFV Tetratricopeptide repeat protein HKK60_RS12600 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HKK60_RS12605 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HKK60_RS12610 ENOG4105CAT Cytidine monophosphate kinase HKK60_RS12615 ENOG4105YK5 50S ribosomal protein L36 HKK60_RS12625 ENOG4105DWY Agmatine deiminase HKK60_RS12645 ENOG4105BZS acriflavin resistance protein HKK60_RS12670 ENOG4105C5H ABC transporter HKK60_RS12675 ENOG4105DUM transcriptional regulator, lysR family HKK60_RS12680 ENOG4105HMI Membrane HKK60_RS12685 ENOG4105C1J atp-dependent rna helicase HKK60_RS12690 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HKK60_RS12695 ENOG4105CNG UPF0061 protein HKK60_RS12705 ENOG4105VEQ Cold shock protein HKK60_RS12710 ENOG4108UPT UPF0178 protein HKK60_RS12715 ENOG4105D3G Pseudouridine synthase HKK60_RS12720 ENOG4108VWS Yaeq family HKK60_RS12725 ENOG4105CBX hi0933 family HKK60_RS12735 ENOG4105RKW reductase (By HKK60_RS12740 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HKK60_RS12745 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HKK60_RS12750 ENOG4105VIE preprotein translocase, subunit YajC HKK60_RS12755 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HKK60_RS12765 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HKK60_RS12770 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HKK60_RS12775 ENOG4108URH decarboxylase HKK60_RS12780 ENOG4105BZU Histidine kinase HKK60_RS12800 ENOG4105BZ1 (ABC) transporter HKK60_RS12820 ENOG4105EU0 Major facilitator Superfamily HKK60_RS12825 ENOG4105R1U AraC Family Transcriptional Regulator HKK60_RS12830 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HKK60_RS12835 ENOG4105CFG Acts as a chaperone (By similarity) HKK60_RS12840 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HKK60_RS12845 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HKK60_RS12850 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HKK60_RS12855 ENOG4105HEI LysR family (Transcriptional regulator HKK60_RS12865 ENOG41090R7 Ferric uptake HKK60_RS12870 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HKK60_RS12880 ENOG4108Z1B Cyclase dehydrase HKK60_RS12885 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HKK60_RS12990 ENOG4105EJC lysr family transcriptional regulator HKK60_RS12995 ENOG4108ZG0 Ompa motb domain protein HKK60_RS13000 ENOG4105CVP deoxyribo-dipyrimidine photolyase HKK60_RS13010 ENOG4105F0N pyrophosphate phospho-hydrolase HKK60_RS13030 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HKK60_RS13050 ENOG4105C8F Beta-lactamase domain protein HKK60_RS13055 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HKK60_RS13060 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HKK60_RS13070 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HKK60_RS13075 ENOG4106H78 methyltransferase HKK60_RS13090 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HKK60_RS13095 ENOG4105CEN a g-specific adenine glycosylase HKK60_RS13100 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HKK60_RS13115 ENOG4105D60 lipoprotein releasing system transmembrane protein HKK60_RS13125 ENOG410681N tpr repeat protein HKK60_RS13130 ENOG4105E33 succinate dehydrogenase HKK60_RS13135 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HKK60_RS13145 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) HKK60_RS13165 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HKK60_RS13170 ENOG4105CHC glucokinase (EC 2.7.1.2) HKK60_RS13180 ENOG4105C01 Dihydroxy-acid dehydratase HKK60_RS13185 ENOG4108UHU Aldolase HKK60_RS13195 ENOG410841Q phosphoesterase PA-phosphatase related protein HKK60_RS13200 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HKK60_RS13205 ENOG4105TX3 Histidine kinase HKK60_RS13215 ENOG4107QP8 phosphohexose isomerase HKK60_RS13220 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HKK60_RS13230 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HKK60_RS13235 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HKK60_RS13240 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HKK60_RS13245 ENOG4105DJ0 Poly(A) Polymerase HKK60_RS13260 ENOG4108Z4U Ferredoxin HKK60_RS13270 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKK60_RS13280 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HKK60_RS13285 ENOG4108IAB Phoh family HKK60_RS13300 ENOG4105DWF phosphomethylpyrimidine kinase HKK60_RS13325 ENOG4105EQ1 Transcriptional regulator HKK60_RS13335 ENOG4105CNM Receptor HKK60_RS13345 ENOG4106UW1 Major Facilitator superfamily HKK60_RS13360 ENOG4105NQN cytochrome C HKK60_RS13370 ENOG4105HSS phospholipase C HKK60_RS13375 ENOG4105DGI Alkaline phosphatase HKK60_RS13400 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HKK60_RS13425 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HKK60_RS13430 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HKK60_RS13435 ENOG4105Y3E Modulates RecA activity (By similarity) HKK60_RS13440 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HKK60_RS13445 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HKK60_RS13450 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HKK60_RS13455 ENOG4107TH8 cina domain protein HKK60_RS13460 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HKK60_RS13465 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HKK60_RS13470 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HKK60_RS13475 ENOG4105EEI dihydropteroate synthase HKK60_RS13485 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HKK60_RS13490 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HKK60_RS13495 ENOG4105HBR Rna-binding protein HKK60_RS13510 ENOG4108K5P (LipO)protein HKK60_RS13520 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HKK60_RS13525 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HKK60_RS13530 ENOG4108DG9 Smr protein MutS2 HKK60_RS13535 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HKK60_RS13540 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HKK60_RS13545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HKK60_RS13550 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HKK60_RS13555 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HKK60_RS13570 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HKK60_RS13575 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HKK60_RS13585 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKK60_RS13590 ENOG4105D9U N-acetyltransferase HKK60_RS13625 ENOG4105DEN Luciferase family HKK60_RS13630 ENOG4105C72 UPF0176 protein HKK60_RS13650 ENOG4105K5X acetyltransferase HKK60_RS13655 ENOG4105CBC glutamate synthase HKK60_RS13660 ENOG4107QQG Dehydrogenase HKK60_RS13675 ENOG4105D4P Coproporphyrinogen iii oxidase HKK60_RS13690 ENOG4105C58 cytochrome c oxidase accessory protein ccog HKK60_RS13710 ENOG41082CG Protein CrcB homolog HKK60_RS13715 ENOG4105E7U AraC family transcriptional regulator HKK60_RS13735 ENOG4106NZI LysR family Transcriptional regulator HKK60_RS13760 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HKK60_RS13820 ENOG4107R39 (ABC) transporter HKK60_RS13860 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HKK60_RS13875 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HKK60_RS13880 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HKK60_RS13885 ENOG4105BZ1 (ABC) transporter HKK60_RS13905 ENOG4106F60 Histidine kinase HKK60_RS13910 ENOG4105XJC Two component transcriptional regulator (Winged helix family HKK60_RS13915 ENOG4105GNX MltA-interacting MipA family protein HKK60_RS13955 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HKK60_RS13970 ENOG4106855 Competence protein HKK60_RS14000 ENOG4105EWT decarboxylase family HKK60_RS14005 ENOG4108KPZ tonB-dependent Receptor HKK60_RS14015 ENOG4105M2J Glutaredoxin HKK60_RS14020 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKK60_RS14030 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HKK60_RS14035 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HKK60_RS14045 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HKK60_RS14060 ENOG4105KB2 stringent starvation protein b HKK60_RS14065 ENOG4107MKT Stringent starvation protein a HKK60_RS14070 ENOG4105EIX cytochrome c1 HKK60_RS14075 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HKK60_RS14080 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HKK60_RS14085 ENOG4105E4C Lytic transglycosylase catalytic HKK60_RS14095 ENOG4108RXX maleylacetoacetate isomerase HKK60_RS14100 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HKK60_RS14105 ENOG4107QWP ABC-2 type transporter HKK60_RS14110 ENOG4105CJ1 ABC, transporter HKK60_RS14120 ENOG4105C9A Phoh family HKK60_RS14125 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HKK60_RS14145 ENOG4108JU5 Magnesium and cobalt efflux protein HKK60_RS14160 ENOG4105C26 Dehydrogenase HKK60_RS14165 ENOG4105D38 putrescine abc transporter HKK60_RS14170 ENOG4105F38 ABC transporter, permease HKK60_RS14175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HKK60_RS14180 ENOG4105H3G oxidoreductase HKK60_RS14190 ENOG4105CFQ glutamine synthetase HKK60_RS14195 ENOG4108Z86 Glutamine amidotransferase HKK60_RS14200 ENOG4105CJP fad dependent oxidoreductase HKK60_RS14220 ENOG4105W3S hemerythrin-like, metal-binding protein HKK60_RS14225 ENOG4105CSH Transporter HKK60_RS14235 ENOG4105C26 Dehydrogenase HKK60_RS14250 ENOG4106BRA Membrane HKK60_RS14270 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HKK60_RS14285 ENOG4105KHC sulfurtransferase HKK60_RS14290 ENOG4105P8F nudix hydrolase HKK60_RS14295 ENOG4108V1T peptidylprolyl cis-trans isomerase HKK60_RS14300 ENOG4105E39 Enoyl-CoA hydratase HKK60_RS14310 ENOG4105CSM endonuclease III HKK60_RS14320 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HKK60_RS14325 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HKK60_RS14330 ENOG4105C8U phosphate abc transporter HKK60_RS14335 ENOG4105E2Z phosphate ABC transporter (Permease HKK60_RS14340 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HKK60_RS14345 ENOG4108UTW Plays a role in the regulation of phosphate uptake HKK60_RS14355 ENOG4105E18 UPF0276 protein HKK60_RS14365 ENOG4109045 doxx family HKK60_RS14370 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HKK60_RS14375 ENOG4105BZU Histidine kinase HKK60_RS14380 ENOG4105E0F Histidine kinase HKK60_RS14390 ENOG4105DJY efflux transporter, rnd family, mfp subunit HKK60_RS14395 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKK60_RS14400 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKK60_RS14405 ENOG4105C2N RNA methyltransferase TrmH family group 3 HKK60_RS14415 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HKK60_RS14435 ENOG4105EGI Transcriptional regulator HKK60_RS14450 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKK60_RS14455 ENOG4105CW7 secretion protein, HlyD family HKK60_RS14475 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKK60_RS14480 ENOG4108UWD Iron-storage protein HKK60_RS14495 ENOG4105CAQ asparagine synthetase HKK60_RS14500 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HKK60_RS14505 ENOG4105KUZ arsenate reductase HKK60_RS14520 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HKK60_RS14525 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HKK60_RS14540 ENOG4105CW0 outer membrane usher protein HKK60_RS14560 ENOG4105CE9 30S ribosomal protein S2 HKK60_RS14565 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HKK60_RS14570 ENOG4105BZU Histidine kinase HKK60_RS14575 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HKK60_RS14580 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HKK60_RS14585 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HKK60_RS14590 ENOG4105KNE Phosphatidate cytidylyltransferase HKK60_RS14600 ENOG4105DZP Membrane-associated zinc metalloprotease HKK60_RS14605 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HKK60_RS14610 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HKK60_RS14620 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HKK60_RS14625 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HKK60_RS14630 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HKK60_RS14645 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HKK60_RS14650 ENOG4108YXA Membrane HKK60_RS14710 ENOG4105FN4 Depolymerizes alginate by cleaving the beta-1,4 glycosidic bond (By similarity) HKK60_RS14715 ENOG4105D6F Phosphatase HKK60_RS14720 ENOG4105BZ1 (ABC) transporter HKK60_RS14725 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) HKK60_RS14745 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HKK60_RS14750 ENOG4105BZU Histidine kinase HKK60_RS14755 ENOG4105FE9 pseudouridine synthase HKK60_RS14760 ENOG4105BZU Histidine kinase HKK60_RS14765 ENOG4105BZU Histidine kinase HKK60_RS14805 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HKK60_RS14825 ENOG4105UGU tonB-dependent Receptor HKK60_RS14845 ENOG4105MYN Zinc uptake regulation protein HKK60_RS14850 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HKK60_RS14865 ENOG4105CT7 inner membrane cred family protein HKK60_RS14870 ENOG4105EB3 Histidine kinase HKK60_RS14875 ENOG4105E3W Two component transcriptional regulator (Winged helix family HKK60_RS14880 ENOG4105D6S protein involved in catabolism of external DNA HKK60_RS14890 ENOG4108JA2 transcriptioN-repair coupling factor HKK60_RS14895 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HKK60_RS14900 ENOG4105C9K Endothelin-converting enzyme 1 HKK60_RS14905 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HKK60_RS14910 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HKK60_RS14925 ENOG4107RNH Outer membrane receptor FepA HKK60_RS14930 ENOG4105BZU Histidine kinase HKK60_RS14950 ENOG4105XJC Two component transcriptional regulator (Winged helix family HKK60_RS14980 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HKK60_RS14985 ENOG4108JPW Aminotransferase HKK60_RS15010 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HKK60_RS15015 ENOG4105NA0 Transcriptional regulator HKK60_RS15020 ENOG4105DR5 peptidase HKK60_RS15025 ENOG4105D05 Receptor HKK60_RS15045 ENOG4107KET secretion protein, HlyD family HKK60_RS15165 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HKK60_RS15170 ENOG4108JJA ABC, transporter HKK60_RS15215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKK60_RS15220 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKK60_RS15260 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKK60_RS15265 ENOG4105BZU Histidine kinase HKK60_RS15270 ENOG4105C8Q Methyl-accepting chemotaxis HKK60_RS15320 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HKK60_RS15370 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKK60_RS15380 ENOG4107ZXU DSBA oxidoreductase HKK60_RS15395 ENOG4105CHR reductase HKK60_RS15420 ENOG4105MVH Clavaminate synthase HKK60_RS15445 ENOG4105CH6 catalase HKK60_RS15455 ENOG4105VEJ Heat shock protein HKK60_RS15465 ENOG4107QJQ Mate efflux family protein HKK60_RS15485 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HKK60_RS15490 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HKK60_RS15495 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HKK60_RS15500 ENOG4105K5M 30s ribosomal protein S16 HKK60_RS15510 ENOG4107QWG 2-Nitropropane dioxygenase HKK60_RS15515 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HKK60_RS15535 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HKK60_RS15540 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HKK60_RS15545 ENOG4105BZU Histidine kinase HKK60_RS15550 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HKK60_RS15555 ENOG4105CCU oxidase (Subunit III) HKK60_RS15560 ENOG4105BZ9 Cytochrome C oxidase, subunit I HKK60_RS15565 ENOG4105E2S oxidase) subunit II HKK60_RS15610 ENOG4105C5I Dehydrogenase HKK60_RS15630 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS15670 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HKK60_RS15675 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HKK60_RS15680 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HKK60_RS15685 ENOG4105DTN riboflavin biosynthesis protein ribF HKK60_RS15690 ENOG4105CJR Integral membrane protein (MviN HKK60_RS15695 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HKK60_RS15700 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HKK60_RS15705 ENOG4105K46 50S ribosomal protein l27 HKK60_RS15710 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HKK60_RS15715 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HKK60_RS15720 ENOG4108TGP Thioesterase superfamily protein HKK60_RS15740 ENOG4105C29 acyl-CoA thioesterase HKK60_RS15750 ENOG4105GFR rna polymerase sigma factor HKK60_RS15760 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate HKK60_RS15770 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HKK60_RS15810 ENOG4105WH1 Two component transcriptional regulator luxr family HKK60_RS15815 ENOG4105BZU Histidine kinase HKK60_RS15830 ENOG4107QMS site-determining protein HKK60_RS15835 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HKK60_RS15850 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HKK60_RS15855 ENOG4105EPD Oligopeptide transporter, Opt family HKK60_RS15870 ENOG4105DUX Transporter HKK60_RS15895 ENOG4105DWT malate dehydrogenase (quinone) HKK60_RS15900 ENOG4105CNM Receptor HKK60_RS15910 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) HKK60_RS15930 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HKK60_RS15945 ENOG4105DRR Transcriptional regulator, GntR family HKK60_RS15960 ENOG4105CSH Transporter HKK60_RS15970 ENOG4105E0F Histidine kinase HKK60_RS15990 ENOG4109045 doxx family HKK60_RS16000 ENOG4105E18 UPF0276 protein HKK60_RS16010 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HKK60_RS16015 ENOG4105DIN metallophosphoesterase HKK60_RS16020 ENOG4105EE5 Membrane protein terC HKK60_RS16025 ENOG4105VMP Transcriptional regulator HKK60_RS16040 ENOG41082BM Transcriptional regulator, arsr family HKK60_RS16065 ENOG4105BZU Histidine kinase HKK60_RS16075 ENOG4105BZU Histidine kinase HKK60_RS16080 ENOG4105ETE Transcriptional regulator (LacI family HKK60_RS16090 ENOG4105EAA nucleoside HKK60_RS16105 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) HKK60_RS16130 ENOG4108UUM single-stranded DNA-binding protein HKK60_RS16135 ENOG4105ETE Transcriptional regulator (LacI family HKK60_RS16140 ENOG4105DA5 (ABC) transporter HKK60_RS16170 ENOG4107RBJ symporter HKK60_RS16190 ENOG4105CG3 alpha amylase, catalytic region HKK60_RS16195 ENOG4105EAH synthase HKK60_RS16215 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HKK60_RS16225 ENOG4105CFH Aspartokinase HKK60_RS16235 ENOG4105JAB phenazine biosynthesis protein, phzf family HKK60_RS16240 ENOG4108Z9K Osmotically inducible protein HKK60_RS16265 ENOG4108Z0Z intracellular protease Pfpi family HKK60_RS16290 ENOG4105C3K feS assembly ATPase SufC HKK60_RS16295 ENOG4105JRK feS assembly protein SufD HKK60_RS16300 ENOG4105C9B Cysteine desulfurase HKK60_RS16315 ENOG4105VQD rieske 2fe-2S domain-containing protein HKK60_RS16325 ENOG4108ESX Receptor HKK60_RS16335 ENOG4107E2E PKHD-type hydroxylase HKK60_RS16345 ENOG4105D05 Receptor HKK60_RS16365 ENOG4105CJ2 (LipO)protein HKK60_RS16390 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HKK60_RS16400 ENOG4105Y3U Transglycosylase-associated protein HKK60_RS16405 ENOG4105EHM Aminoglycoside phosphotransferase HKK60_RS16410 ENOG4108S0S Nucleotidyl transferase HKK60_RS16420 ENOG4105C02 permease HKK60_RS16430 ENOG4105CXB phosphoribosylaminoimidazole synthetase HKK60_RS16450 ENOG4108V3E phosphoribosylglycinamide formyltransferase HKK60_RS16470 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HKK60_RS16480 ENOG4105C2X Arabinose 5-phosphate isomerase HKK60_RS16500 ENOG4108IUZ ABC transporter HKK60_RS16505 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKK60_RS16510 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HKK60_RS16515 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HKK60_RS16520 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HKK60_RS16525 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HKK60_RS16540 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HKK60_RS16545 ENOG4105CJW magnesium transporter HKK60_RS16565 ENOG4105CXT aspartate transcarbamylase HKK60_RS16570 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HKK60_RS16575 ENOG4108UJU UPF0301 protein HKK60_RS16580 ENOG4108MAJ Membrane HKK60_RS16585 ENOG4108R3E Dna-3-methyladenine glycosylase i HKK60_RS16600 ENOG4105EQ2 LysR family Transcriptional regulator HKK60_RS16605 ENOG4107SET aldo keto reductase HKK60_RS16610 ENOG4105CZX twitching motility protein HKK60_RS16615 ENOG4105CZX twitching motility protein HKK60_RS16620 ENOG4105DFA alanine racemase domain protein HKK60_RS16625 ENOG4105II7 pyrroline-5-carboxylate reductase HKK60_RS16630 ENOG4105CC0 LysR family Transcriptional regulator HKK60_RS16640 ENOG4108Z4X TRANSCRIPTIONal HKK60_RS16665 ENOG4105C57 major facilitator superfamily HKK60_RS16670 ENOG4105JQN Transcriptional regulator HKK60_RS16675 ENOG4105T38 integral membrane protein HKK60_RS16680 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKK60_RS16685 ENOG4105CR8 Transcriptional regulator HKK60_RS16705 ENOG4105E98 transcriptional regulator DeoR family HKK60_RS16710 ENOG4106UW1 Major Facilitator superfamily HKK60_RS16720 ENOG4105E0K tonB-dependent siderophore receptor HKK60_RS16870 ENOG4107QRG dna polymerase iii HKK60_RS16875 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HKK60_RS16880 ENOG4105HHA aminodeoxychorismate lyase HKK60_RS16890 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HKK60_RS16900 ENOG4105CHR reductase HKK60_RS16905 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HKK60_RS16915 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HKK60_RS16920 ENOG4105VGS 50s ribosomal protein l32 HKK60_RS16925 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HKK60_RS16940 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HKK60_RS16950 ENOG4105F8C transglutaminase domain-containing protein HKK60_RS16960 ENOG4105K59 histidine triad (HIT) protein HKK60_RS16970 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HKK60_RS16975 ENOG4107QMP dna polymerase iii subunits gamma and tau HKK60_RS17090 ENOG4105KPY Small multidrug resistance protein HKK60_RS17105 ENOG4107UV6 ribonuclease Z HKK60_RS17110 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) HKK60_RS17115 ENOG4105DKP glycosyl transferase, family 9 HKK60_RS17135 ENOG4108ZF3 Phosphatase HKK60_RS17140 ENOG4107RZZ dna polymerase iii epsilon subunit HKK60_RS17145 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HKK60_RS17155 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HKK60_RS17160 ENOG41068JE domain protein HKK60_RS17165 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HKK60_RS17200 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HKK60_RS17205 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HKK60_RS17210 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HKK60_RS17275 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HKK60_RS17285 ENOG4105VW4 glutaredoxin 3 HKK60_RS17290 ENOG4105ERG peptidase m48, ste24p HKK60_RS17295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKK60_RS17300 ENOG4105BZU Histidine kinase HKK60_RS17305 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HKK60_RS17310 ENOG4105C9X ppx gppa phosphatase HKK60_RS17320 ENOG4107RNH Outer membrane receptor FepA HKK60_RS17325 ENOG4105BZF Glycosyl transferase (Group 1 HKK60_RS17335 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HKK60_RS17340 ENOG4108YP4 Metalloprotease, specifically cleaves on the N-terminal side of aspartyl, glutamyl and cysteic acid residues (By similarity) HKK60_RS17350 ENOG4105ED9 Protein of unknown function (DUF455) HKK60_RS17355 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HKK60_RS17370 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HKK60_RS17375 ENOG4105CVJ phosphoglycerate mutase HKK60_RS17385 ENOG4105CPQ Dehydrogenase HKK60_RS17395 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HKK60_RS17405 ENOG4105FE9 pseudouridine synthase HKK60_RS17415 ENOG4105CDV Ompa motb domain protein HKK60_RS17420 ENOG4105CIS alcohol dehydrogenase HKK60_RS17425 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HKK60_RS17435 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HKK60_RS17450 ENOG4105C7B Threonine dehydratase HKK60_RS17455 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HKK60_RS17460 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HKK60_RS17475 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HKK60_RS17490 ENOG4108IJF Heavy metal efflux pump, CzcA HKK60_RS17495 ENOG4105ENT Efflux transporter rnd family, mfp subunit HKK60_RS17505 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HKK60_RS17510 ENOG4105DFG type I secretion outer membrane protein HKK60_RS17515 ENOG4105CUB amino acid HKK60_RS17520 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HKK60_RS17525 ENOG4105D1S lipid A biosynthesis HKK60_RS17555 ENOG4105C6K Malic enzyme HKK60_RS17560 ENOG4105CK2 sodium dicarboxylate symporter HKK60_RS17580 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HKK60_RS17585 ENOG4105DHQ Histidine kinase HKK60_RS17600 ENOG4105D4T Citrate transporter HKK60_RS17605 ENOG4105CHR reductase HKK60_RS17630 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HKK60_RS17635 ENOG4105CHM Aminotransferase HKK60_RS17670 ENOG4105CI2 imidazolone-5-propionate hydrolase HKK60_RS17675 ENOG4105CQM Urea amidohydrolase subunit alpha HKK60_RS17685 ENOG4108RMV DegV Family HKK60_RS17695 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKK60_RS17710 ENOG4105G2Y Transcriptional regulator HKK60_RS17730 ENOG4105C4W S-formylglutathione hydrolase HKK60_RS17755 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKK60_RS17780 ENOG410642W LysR family Transcriptional regulator HKK60_RS17785 ENOG4105DQ4 alcohol dehydrogenase HKK60_RS17805 ENOG4105CY0 Metallo-Beta-Lactamase HKK60_RS17810 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HKK60_RS17815 ENOG4106RE7 Cytochrome HKK60_RS17820 ENOG4108Z33 Thiol disulfide Interchange Protein HKK60_RS17825 ENOG4108Z33 Thiol disulfide Interchange Protein HKK60_RS17850 ENOG4105CNM Receptor HKK60_RS17860 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS17880 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HKK60_RS17915 ENOG4105F4K antigen 43 HKK60_RS17925 ENOG4105CE4 GlcNAc 6-P deacetylase HKK60_RS17930 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HKK60_RS17935 ENOG4107KJX Transcriptional regulator HKK60_RS17945 ENOG4105CHC glucokinase (EC 2.7.1.2) HKK60_RS17955 ENOG4105E2D ec 3.2.1.52 HKK60_RS17990 ENOG4105BZU Histidine kinase HKK60_RS18000 ENOG4105BZU Histidine kinase HKK60_RS18005 ENOG4105W4M Transport-associated protein HKK60_RS18010 ENOG4105D9R oxidoreductase HKK60_RS18015 ENOG4108J5G 6-phosphogluconate dehydrogenase HKK60_RS18030 ENOG4105CN1 protease HKK60_RS18035 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HKK60_RS18055 ENOG4105DZ1 carboxypeptidase HKK60_RS18060 ENOG4105K6T rare lipoprotein A HKK60_RS18065 ENOG4105CVE Lytic murein transglycosylase HKK60_RS18070 ENOG4105CNI cell division protein FtsW HKK60_RS18075 ENOG4105CNI cell division protein FtsW HKK60_RS18090 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HKK60_RS18100 ENOG4107T4Z adenosine kinase HKK60_RS18115 ENOG4105CD8 aminopeptidase N HKK60_RS18120 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKK60_RS18145 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKK60_RS18150 ENOG4105BZS acriflavin resistance protein HKK60_RS18155 ENOG4105C1P efflux transporter, rnd family, mfp subunit HKK60_RS18175 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HKK60_RS18190 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HKK60_RS18200 ENOG4105WD1 Membrane HKK60_RS18230 ENOG4108UMI ABC transporter, permease HKK60_RS18235 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HKK60_RS18240 ENOG4108EHX EamA-like transporter family HKK60_RS18245 ENOG4108VPT UPF0234 protein HKK60_RS18255 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HKK60_RS18260 ENOG4105DGW oligopeptidase A HKK60_RS18270 ENOG4105C6T cysteine synthase HKK60_RS18295 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HKK60_RS18305 ENOG4105C19 ABC transporter HKK60_RS18310 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKK60_RS18315 ENOG4107RBB ABC transporter, permease HKK60_RS18325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HKK60_RS18330 ENOG4105BZU Histidine kinase HKK60_RS18340 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HKK60_RS18350 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HKK60_RS18355 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HKK60_RS18360 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HKK60_RS18365 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HKK60_RS18370 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HKK60_RS18375 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HKK60_RS18380 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HKK60_RS18385 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) HKK60_RS18400 ENOG4107QN2 dihydrolipoyl dehydrogenase HKK60_RS18405 ENOG4107QSN dihydrolipoamide acetyltransferase HKK60_RS18420 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HKK60_RS18425 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HKK60_RS18430 ENOG4105D01 (LipO)protein HKK60_RS18450 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HKK60_RS18455 ENOG4108NEV two component transcriptional regulator, LytTR family HKK60_RS18475 ENOG4105D05 Receptor HKK60_RS18485 ENOG4105NRM Membrane HKK60_RS18510 ENOG4105C57 major facilitator superfamily HKK60_RS18555 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS18585 ENOG4108VBZ doxx family HKK60_RS18630 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKK60_RS18635 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HKK60_RS18645 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HKK60_RS18670 ENOG4107T8Q Glycosyl transferase (Group 1 HKK60_RS18680 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HKK60_RS18685 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HKK60_RS18690 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HKK60_RS18700 ENOG4105C79 DNA protecting protein DprA HKK60_RS18705 ENOG4108RPN Protein smg homolog HKK60_RS18720 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HKK60_RS18725 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HKK60_RS18740 ENOG4107ZQV short-chain dehydrogenase reductase HKK60_RS18750 ENOG4105D07 Signal peptide peptidase, SppA HKK60_RS18755 ENOG4107QI1 Mate efflux family protein HKK60_RS18770 ENOG4105C25 Primosomal protein n' HKK60_RS18775 ENOG4108TGY Glutathione S-transferase HKK60_RS18800 ENOG41082IR Excinuclease ABC C subunit domain protein HKK60_RS18805 ENOG4105EN6 Membrane HKK60_RS18810 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HKK60_RS18830 ENOG41082F9 transcriptional regulator HKK60_RS18835 ENOG4105E0F Histidine kinase HKK60_RS18860 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HKK60_RS18865 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HKK60_RS18870 ENOG4108K8S endonuclease I HKK60_RS18875 ENOG4105VF7 tolerance protein HKK60_RS18880 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HKK60_RS18885 ENOG4107QX9 Thiol disulfide interChange protein HKK60_RS18895 ENOG4105C8Q Methyl-accepting chemotaxis HKK60_RS18900 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HKK60_RS18915 ENOG4105BZU Histidine kinase HKK60_RS18935 ENOG4108PZW LysR family Transcriptional regulator HKK60_RS18950 ENOG4105G6Z alkaline phosphatase HKK60_RS18955 ENOG4105DZ1 carboxypeptidase HKK60_RS18965 ENOG4105DYS nad(p)h dehydrogenase (quinone) HKK60_RS18975 ENOG4105CR4 methylisocitrate lyase HKK60_RS18985 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HKK60_RS18990 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HKK60_RS18995 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HKK60_RS19010 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HKK60_RS19020 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HKK60_RS19025 ENOG4108HPI phosphatidate Cytidylyltransferase HKK60_RS19030 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HKK60_RS19040 ENOG41077RS Phosphatase HKK60_RS19045 ENOG4105E8V Alpha Beta Hydrolase Fold protein HKK60_RS19050 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HKK60_RS19055 ENOG4105DC1 bifunctional purine biosynthesis protein purh HKK60_RS19060 ENOG4105C12 Phosphoribosylglycinamide synthetase HKK60_RS19075 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKK60_RS19080 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HKK60_RS19085 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HKK60_RS19090 ENOG4105CRP Part of the ABC transporter FtsEX involved in HKK60_RS19095 ENOG4105CAK Cell division ATP-binding protein ftsE HKK60_RS19110 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HKK60_RS19115 ENOG4105BZU Histidine kinase HKK60_RS19125 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HKK60_RS19150 ENOG4105E9K Isocitrate dehydrogenase HKK60_RS19160 ENOG4109066 lysm domain bon superfamily protein HKK60_RS19165 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HKK60_RS19170 ENOG4105CH2 amidohydrolase HKK60_RS19175 ENOG4105ENT Efflux transporter rnd family, mfp subunit HKK60_RS19180 ENOG4105BZS acriflavin resistance protein HKK60_RS19185 ENOG4105BZS acriflavin resistance protein HKK60_RS19190 ENOG4105EM2 membrane HKK60_RS19195 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HKK60_RS19200 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) HKK60_RS19230 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HKK60_RS19255 ENOG4105BZU Histidine kinase HKK60_RS19260 ENOG4108UQY Iron-storage protein HKK60_RS19270 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HKK60_RS19285 ENOG4108UJD 30S ribosomal protein S9 HKK60_RS19290 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HKK60_RS19300 ENOG4105KPY Small multidrug resistance protein HKK60_RS19305 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HKK60_RS19310 ENOG4107RYR Transcriptional regulator, Crp Fnr family HKK60_RS19315 ENOG410635A Membrane HKK60_RS19325 ENOG4105DK0 Indole-3-glycerol phosphate synthase HKK60_RS19330 ENOG4107QYG anthranilate phosphoribosyltransferase HKK60_RS19335 ENOG4105DDQ anthranilate synthase HKK60_RS19345 ENOG4105CRQ synthase (Component I) HKK60_RS19350 ENOG4107TE5 Lipid kinase HKK60_RS19365 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HKK60_RS19370 ENOG4105C8V SAICAR synthetase HKK60_RS19380 ENOG4105D65 subunit l HKK60_RS19385 ENOG4108ZE9 Monovalent cation H antiporter subunit C HKK60_RS19390 ENOG4107R4Z monovalent cation h antiporter subunit d HKK60_RS19395 ENOG4105SC1 monovalent cation H antiporter subunit E HKK60_RS19400 ENOG4105W4C monovalent cation H antiporter subunit F HKK60_RS19405 ENOG4105KJM monovalent cation h antiporter subunit g HKK60_RS19410 ENOG4105FEU K -dependent Na -Ca exchanger HKK60_RS19430 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HKK60_RS19450 ENOG4105DUX Transporter HKK60_RS19455 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HKK60_RS19460 ENOG4107RUY (E1 component), alpha subunit HKK60_RS19475 ENOG4107QSN dihydrolipoamide acetyltransferase HKK60_RS19485 ENOG4105D29 Helix-turn-helix type 11 domain protein HKK60_RS19495 ENOG4105BZU Histidine kinase HKK60_RS19500 ENOG4105CKW Inner membrane protein yedI HKK60_RS19505 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HKK60_RS19510 ENOG4107RES phosphoglycerol transferase I HKK60_RS19515 ENOG4105EGS Mechanosensitive ion channel HKK60_RS19530 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HKK60_RS19550 ENOG4105XJC Two component transcriptional regulator (Winged helix family HKK60_RS19565 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HKK60_RS19570 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HKK60_RS19590 ENOG4108YZA Nitrogen regulatory protein pii HKK60_RS19595 ENOG4105W0Z cytoplasmic protein HKK60_RS19605 ENOG4105W0Z cytoplasmic protein HKK60_RS19655 ENOG4105C0P Mg chelatase subunit ChlI HKK60_RS19680 ENOG410667J hydrolase HKK60_RS19685 ENOG4108TPP exopolysaccharide synthesis HKK60_RS19715 ENOG4108ZX6 Electron transport protein SCO1 SenC HKK60_RS19720 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HKK60_RS19725 ENOG4105CCU oxidase (Subunit III) HKK60_RS19730 ENOG4105BZ9 Cytochrome C oxidase, subunit I HKK60_RS19735 ENOG4105E2S oxidase) subunit II HKK60_RS19740 ENOG4107SQD Transcriptional regulator, GntR family HKK60_RS19755 ENOG4107SQD Transcriptional regulator, GntR family HKK60_RS19760 ENOG4105C3J Cysteine desulfurase HKK60_RS19815 ENOG4105CRW Short chain fatty acid transporter HKK60_RS19850 ENOG4105EPC oxidoreductase HKK60_RS19855 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKK60_RS19865 ENOG4105E70 isomerase HKK60_RS19870 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HKK60_RS19875 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HKK60_RS19880 ENOG4105E98 transcriptional regulator DeoR family HKK60_RS19885 ENOG4105CE4 GlcNAc 6-P deacetylase HKK60_RS19890 ENOG4107QNK )-transporter HKK60_RS19905 ENOG4105MJ2 Competence protein HKK60_RS19925 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HKK60_RS19930 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HKK60_RS19935 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HKK60_RS19940 ENOG4105CHR reductase HKK60_RS19970 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKK60_RS19980 ENOG4105C1P efflux transporter, rnd family, mfp subunit HKK60_RS19985 ENOG4105EB3 Histidine kinase HKK60_RS19990 ENOG4105E3W Two component transcriptional regulator (Winged helix family HKK60_RS19995 ENOG410756H nucleotidyltransferase HKK60_RS20000 ENOG4108Z0R Transferase HKK60_RS20025 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HKK60_RS20040 ENOG4106032 Glutathionylspermidine synthase HKK60_RS20050 ENOG4105C01 Dihydroxy-acid dehydratase HKK60_RS20060 ENOG4105DVT helicase HKK60_RS20070 ENOG4105E2X shikimate dehydrogenase HKK60_RS20085 ENOG4105D52 delta-aminolevulinic acid dehydratase HKK60_RS20090 ENOG4105FFC UPF0187 protein HKK60_RS20120 ENOG4105CYM Glutathione S-transferase HKK60_RS20125 ENOG4108TEB UPF0114 protein HKK60_RS20140 ENOG4105R1U AraC Family Transcriptional Regulator HKK60_RS20155 ENOG4108IUW ABC transporter HKK60_RS20185 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HKK60_RS20190 ENOG4105DA5 (ABC) transporter HKK60_RS20195 ENOG4105E3A (ABC) transporter HKK60_RS20205 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HKK60_RS20215 ENOG4105F8V Hydrolase, tatD family HKK60_RS20220 ENOG4105CQ7 ATP-dependent helicase HKK60_RS20230 ENOG4108R99 pseudouridine synthase HKK60_RS20245 ENOG4105CPC Aldo Keto reductase HKK60_RS20260 ENOG4105E0Y RtcB Protein HKK60_RS20275 ENOG4105C8Q Methyl-accepting chemotaxis HKK60_RS20280 ENOG4105HEI LysR family (Transcriptional regulator HKK60_RS20285 ENOG4105F27 Major Facilitator HKK60_RS20290 ENOG4105CV8 reductase HKK60_RS20295 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HKK60_RS20300 ENOG41082CH UPF0145 protein HKK60_RS20305 ENOG4105CD5 CoA-binding domain protein HKK60_RS20310 ENOG4105CJW magnesium transporter HKK60_RS20315 ENOG4105CKD glutathione-regulated potassium-efflux system protein HKK60_RS20320 ENOG4107PTR Ankyrin repeat HKK60_RS20325 ENOG4105VNG YcgL domain-containing protein HKK60_RS20335 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HKK60_RS20340 ENOG4105C2D reductase HKK60_RS20380 ENOG4105C84 Histidine ammonia-lyase HKK60_RS20390 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HKK60_RS20410 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HKK60_RS20425 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HKK60_RS20430 ENOG4105C4M (Ubiquinol oxidase) subunit I HKK60_RS20450 ENOG4105EMN RNA polymerase sigma factor HKK60_RS20485 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HKK60_RS20495 ENOG4105H67 Protein of unknown function (DUF421) HKK60_RS20500 ENOG4105C2M dna polymerase I HKK60_RS20525 ENOG4105C4R Atp-dependent dna helicase HKK60_RS20535 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HKK60_RS20545 ENOG4105W0E 50S ribosomal protein L33 HKK60_RS20550 ENOG4105KDC 50s ribosomal protein l28 HKK60_RS20570 ENOG4108UQ8 endoribonuclease L-psp HKK60_RS20605 ENOG4105CKK Glycosyl transferase, family 2 HKK60_RS20620 ENOG4105FA0 parb-like partition protein HKK60_RS20625 ENOG4107QJE Chromosome Partitioning Protein HKK60_RS20630 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HKK60_RS20650 ENOG4107RGH Aldehyde dehydrogenase HKK60_RS20655 ENOG4105CSH Transporter HKK60_RS20665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HKK60_RS20675 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HKK60_RS20680 ENOG4105BZU Histidine kinase HKK60_RS20690 ENOG4105MA0 exported protein HKK60_RS20695 ENOG4105CFU surface antigen HKK60_RS20700 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HKK60_RS20705 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HKK60_RS20710 ENOG4107QHF type ii secretion system protein e HKK60_RS20715 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HKK60_RS20725 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HKK60_RS20730 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HKK60_RS20735 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HKK60_RS20745 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HKK60_RS20755 ENOG4105C8Q Methyl-accepting chemotaxis HKK60_RS20785 ENOG4105DKK Benzoate HKK60_RS20795 ENOG4105DSB aldose 1-epimerase HKK60_RS20800 ENOG4105CVE Lytic murein transglycosylase HKK60_RS20805 ENOG41067HS methyltransferase HKK60_RS20815 ENOG4106TD9 Diguanylate cyclase HKK60_RS20845 ENOG4105EUJ GTP cyclohydrolase i HKK60_RS20855 ENOG4105ZQC membrane protein AaeX HKK60_RS20860 ENOG4105Y49 secretion protein, HlyD family HKK60_RS20865 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKK60_RS20870 ENOG4105DR8 Membrane HKK60_RS20885 ENOG4107QKA exodeoxyribonuclease V beta HKK60_RS20890 ENOG4105DSY exodeoxyribonuclease V, gamma HKK60_RS20895 ENOG4105DHJ ABC, transporter HKK60_RS20900 ENOG4105CY3 ABC transporter, permease HKK60_RS20905 ENOG4107PE3 Mammalian cell entry related domain protein HKK60_RS20920 ENOG410903C (LipO)protein HKK60_RS20925 ENOG4108V06 Glutathione peroxidase HKK60_RS20935 ENOG4107QSV RmuC domain protein HKK60_RS20970 ENOG4105CUB amino acid HKK60_RS20980 ENOG4105DR4 Methyltransferase HKK60_RS20985 ENOG4105DU1 integral membrane protein, terc HKK60_RS20995 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HKK60_RS21010 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HKK60_RS21015 ENOG41067YR RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HKK60_RS21020 ENOG4105VG0 50S ribosomal protein l34