locus-tag	class	description
GS396_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GS396_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GS396_RS00020	COG0187	DNA topoisomerase II activity
GS396_RS00030	COG0501	Belongs to the peptidase M48B family
GS396_RS00110	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GS396_RS00125	COG4772	TonB-dependent receptor
GS396_RS00160	COG0800	Aldolase
GS396_RS00165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GS396_RS00185	COG2272	Belongs to the type-B carboxylesterase lipase family
GS396_RS00200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GS396_RS00215	COG3507	Belongs to the glycosyl hydrolase 43 family
GS396_RS00220	COG1609	Transcriptional regulator
GS396_RS00230	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS00235	COG2755	lipolytic protein G-D-S-L family
GS396_RS00245	COG3186	Phenylalanine-4-hydroxylase
GS396_RS00250	COG1522	sequence-specific DNA binding
GS396_RS00260	COG1752	Esterase of the alpha-beta hydrolase superfamily
GS396_RS00275	COG0671	phosphoesterase, PA-phosphatase related
GS396_RS00290	COG1119	ATPase activity
GS396_RS00305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GS396_RS00310	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GS396_RS00315	COG1435	thymidine kinase activity
GS396_RS00320	COG0210	DNA helicase
GS396_RS00330	COG3132	Protein of unknown function, DUF480
GS396_RS00335	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GS396_RS00340	COG0284	orotidine-5'-phosphate decarboxylase activity
GS396_RS00350	COG2937	Belongs to the GPAT DAPAT family
GS396_RS00360	COG0037	tRNA processing
GS396_RS00365	COG2974	May be involved in recombination
GS396_RS00375	COG1803	Methylglyoxal synthase
GS396_RS00380	COG2205	protein histidine kinase activity
GS396_RS00380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GS396_RS00385	COG0493	'glutamate synthase
GS396_RS00390	COG0070	glutamate synthase
GS396_RS00390	COG0069	glutamate synthase activity
GS396_RS00390	COG0067	glutamate synthase
GS396_RS00410	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS00440	COG1111	helicase
GS396_RS00440	COG1205	dead DEAH box helicase
GS396_RS00480	COG0714	Associated with various cellular activities
GS396_RS00500	COG0312	modulator of DNA gyrase
GS396_RS00535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GS396_RS00555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GS396_RS00595	COG1968	undecaprenyl-diphosphatase activity
GS396_RS00600	COG0174	glutamine synthetase
GS396_RS00605	COG0347	Belongs to the P(II) protein family
GS396_RS00610	COG0004	ammonium transporteR
GS396_RS00615	COG3023	N-Acetylmuramoyl-L-alanine amidase
GS396_RS00620	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GS396_RS00640	COG3852	Histidine kinase
GS396_RS00645	COG2204	response regulator
GS396_RS00650	COG2032	superoxide dismutase activity
GS396_RS00655	COG2032	superoxide dismutase activity
GS396_RS00665	COG0183	Belongs to the thiolase family
GS396_RS00700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GS396_RS00705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GS396_RS00725	COG0798	PFAM Bile acid sodium symporter
GS396_RS00740	COG0431	NADPH-dependent FMN reductase
GS396_RS00775	COG2837	iron assimilation
GS396_RS00815	COG2197	response regulator
GS396_RS00820	COG2205	protein histidine kinase activity
GS396_RS00820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GS396_RS00825	COG3474	cytochrome
GS396_RS00835	COG1960	acyl-CoA dehydrogenase activity
GS396_RS00840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GS396_RS00850	COG0612	Peptidase, M16
GS396_RS00860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GS396_RS00865	COG0596	Alpha beta hydrolase
GS396_RS00875	COG0318	PFAM AMP-dependent synthetase and ligase
GS396_RS00880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GS396_RS00890	COG1181	Belongs to the D-alanine--D-alanine ligase family
GS396_RS00930	COG0339	signal peptide processing
GS396_RS00945	COG0681	Belongs to the peptidase S26 family
GS396_RS00950	COG2814	Major facilitator Superfamily
GS396_RS00955	COG0583	DNA-binding transcription factor activity
GS396_RS00965	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GS396_RS00970	COG2224	Isocitrate lyase
GS396_RS00975	COG3706	GGDEF domain
GS396_RS01000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GS396_RS01005	COG1960	acyl-CoA dehydrogenase activity
GS396_RS01025	COG0697	spore germination
GS396_RS01035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GS396_RS01050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GS396_RS01055	COG1280	lysine exporter protein (LysE YggA)
GS396_RS01060	COG1607	acyl-coa hydrolase
GS396_RS01070	COG1902	pentaerythritol trinitrate reductase activity
GS396_RS01085	COG1335	isochorismatase
GS396_RS01090	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GS396_RS01095	COG1752	Esterase of the alpha-beta hydrolase superfamily
GS396_RS01100	COG1396	sequence-specific DNA binding
GS396_RS01100	COG3800	Transcriptional regulator
GS396_RS01110	COG1960	acyl-CoA dehydrogenase activity
GS396_RS01115	COG1024	Enoyl-CoA hydratase
GS396_RS01120	COG1024	Enoyl-CoA hydratase
GS396_RS01130	COG1764	response to oxidative stress
GS396_RS01140	COG0659	secondary active sulfate transmembrane transporter activity
GS396_RS01150	COG3657	addiction module killer protein
GS396_RS01155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GS396_RS01165	COG0745	RESPONSE REGULATOR receiver
GS396_RS01170	COG2205	protein histidine kinase activity
GS396_RS01175	COG3228	Belongs to the MtfA family
GS396_RS01185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GS396_RS01185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GS396_RS01190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GS396_RS01240	COG3237	CsbD-like
GS396_RS01250	COG0180	Tryptophanyl-tRNA synthetase
GS396_RS01275	COG0477	Major facilitator Superfamily
GS396_RS01280	COG0697	spore germination
GS396_RS01290	COG4206	TonB-dependent receptor
GS396_RS01295	COG0577	efflux transmembrane transporter activity
GS396_RS01295	COG1136	(ABC) transporter
GS396_RS01305	COG1136	(ABC) transporter
GS396_RS01315	COG1131	(ABC) transporter
GS396_RS01325	COG4585	Histidine kinase
GS396_RS01330	COG2197	response regulator
GS396_RS01335	COG3038	cytochrome b561
GS396_RS01345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GS396_RS01350	COG0546	phosphoglycolate phosphatase activity
GS396_RS01360	COG0628	permease
GS396_RS01380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GS396_RS01395	COG5507	3-demethylubiquinone-9 3-methyltransferase
GS396_RS01420	COG2814	Major facilitator Superfamily
GS396_RS01425	COG0583	DNA-binding transcription factor activity
GS396_RS01430	COG4807	Protein conserved in bacteria
GS396_RS01440	COG4221	oxidoreductase activity
GS396_RS01480	COG0018	arginyl-trna synthetase
GS396_RS01485	COG2003	Belongs to the UPF0758 family
GS396_RS01490	COG2197	response regulator
GS396_RS01495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GS396_RS01500	COG0756	dUTP diphosphatase activity
GS396_RS01515	COG2205	protein histidine kinase activity
GS396_RS01525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GS396_RS01530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GS396_RS01545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GS396_RS01550	COG0708	Exodeoxyribonuclease III
GS396_RS01555	COG2223	nitrite transmembrane transporter activity
GS396_RS01565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GS396_RS01570	COG0739	heme binding
GS396_RS01645	COG4942	peptidase
GS396_RS01650	COG0793	Belongs to the peptidase S41A family
GS396_RS01680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GS396_RS01710	COG3346	SURF1 family
GS396_RS01725	COG0109	protoheme IX farnesyltransferase activity
GS396_RS01740	COG0358	DNA primase activity
GS396_RS01745	COG1295	ribonuclease BN
GS396_RS01755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GS396_RS01760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GS396_RS01770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GS396_RS01775	COG0668	transmembrane transport
GS396_RS01790	COG2133	pyrroloquinoline quinone binding
GS396_RS01795	COG4682	membrane
GS396_RS01805	COG0531	amino acid
GS396_RS01815	COG1737	Transcriptional regulator
GS396_RS01820	COG4948	Mandelate Racemase Muconate Lactonizing
GS396_RS01870	COG5383	Protein conserved in bacteria
GS396_RS01880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GS396_RS01885	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GS396_RS01915	COG0778	Nitroreductase
GS396_RS01920	COG2353	YceI-like domain
GS396_RS01935	COG2375	cellular response to nickel ion
GS396_RS01950	COG0210	DNA helicase
GS396_RS02040	COG2267	carboxylic ester hydrolase activity
GS396_RS02105	COG0583	DNA-binding transcription factor activity
GS396_RS02115	COG2814	Major facilitator Superfamily
GS396_RS02120	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GS396_RS02125	COG1113	amino acid transport
GS396_RS02130	COG0741	lytic transglycosylase activity
GS396_RS02160	COG2764	glyoxalase bleomycin resistance protein dioxygenase
GS396_RS02170	COG5507	3-demethylubiquinone-9 3-methyltransferase
GS396_RS02175	COG4941	Belongs to the sigma-70 factor family
GS396_RS02205	COG3275	phosphorelay sensor kinase activity
GS396_RS02210	COG3279	Response regulator of the LytR AlgR family
GS396_RS02230	COG3590	peptidase
GS396_RS02235	COG5001	Diguanylate cyclase
GS396_RS02240	COG0583	DNA-binding transcription factor activity
GS396_RS02250	COG3384	dioxygenase
GS396_RS02255	COG0025	NhaP-type Na H and K H
GS396_RS02280	COG1360	Flagellar Motor Protein
GS396_RS02305	COG1522	sequence-specific DNA binding
GS396_RS02310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GS396_RS02325	COG5002	protein histidine kinase activity
GS396_RS02340	COG2813	Specifically methylates the guanine in position
GS396_RS02345	COG1187	pseudouridine synthase activity
GS396_RS02350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GS396_RS02360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GS396_RS02365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GS396_RS02380	COG0583	DNA-binding transcription factor activity
GS396_RS02385	COG2226	methyltransferase
GS396_RS02410	COG1956	GAF domain-containing protein
GS396_RS02415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GS396_RS02420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GS396_RS02425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GS396_RS02430	COG0785	Cytochrome C biogenesis protein
GS396_RS02430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GS396_RS02435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GS396_RS02440	COG0745	RESPONSE REGULATOR receiver
GS396_RS02445	COG5002	protein histidine kinase activity
GS396_RS02450	COG2205	protein histidine kinase activity
GS396_RS02455	COG0745	RESPONSE REGULATOR receiver
GS396_RS02460	COG0367	asparagine synthase
GS396_RS02470	COG0720	synthase
GS396_RS02485	COG0513	Belongs to the DEAD box helicase family
GS396_RS02495	COG0625	glutathione transferase activity
GS396_RS02500	COG1573	uracil-dna glycosylase
GS396_RS02535	COG0626	cystathionine gamma-synthase activity
GS396_RS02555	COG1216	Glycosyl transferase, family 2
GS396_RS02555	COG0438	transferase activity, transferring glycosyl groups
GS396_RS02575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GS396_RS02580	COG2076	Multidrug Resistance protein
GS396_RS02590	COG0463	Glycosyl transferase, family 2
GS396_RS02600	COG2086	electron transfer activity
GS396_RS02630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GS396_RS02635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GS396_RS02670	COG1127	ABC transporter
GS396_RS02675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GS396_RS02690	COG0442	prolyl-tRNA aminoacylation
GS396_RS02700	COG1183	phosphatidylcholine synthase activity
GS396_RS02720	COG0525	valine-tRNA ligase activity
GS396_RS02730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GS396_RS02740	COG0795	lipopolysaccharide-transporting ATPase activity
GS396_RS02750	COG4974	Belongs to the 'phage' integrase family
GS396_RS02755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GS396_RS02765	COG0047	phosphoribosylformylglycinamidine synthase activity
GS396_RS02765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GS396_RS02770	COG5295	Hep Hag repeat protein
GS396_RS02775	COG1404	Belongs to the peptidase S8 family
GS396_RS02780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GS396_RS02785	COG1459	type II secretion system
GS396_RS02790	COG2165	general secretion pathway protein
GS396_RS02795	COG4970	Tfp pilus assembly protein FimT
GS396_RS02800	COG2165	general secretion pathway protein
GS396_RS02805	COG4795	General secretion pathway protein
GS396_RS02810	COG3156	type II secretion system protein K
GS396_RS02815	COG3166	PFAM Fimbrial assembly family protein
GS396_RS02830	COG1450	Type ii and iii secretion system protein
GS396_RS02840	COG0463	Glycosyl transferase, family 2
GS396_RS02855	COG3539	Fimbrial protein
GS396_RS02875	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GS396_RS02885	COG1215	transferase activity, transferring glycosyl groups
GS396_RS02900	COG2252	PERMEase
GS396_RS02905	COG0488	(ABC) transporter
GS396_RS02915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GS396_RS02930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GS396_RS02935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GS396_RS02935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GS396_RS02965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GS396_RS02970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GS396_RS02975	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GS396_RS02985	COG3121	Chaperone
GS396_RS03000	COG3188	usher protein
GS396_RS03025	COG0277	FAD linked oxidase domain protein
GS396_RS03030	COG1988	membrane-bound metal-dependent
GS396_RS03065	COG2001	Belongs to the MraZ family
GS396_RS03070	COG0275	rRNA processing
GS396_RS03075	COG3116	cell division
GS396_RS03085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GS396_RS03090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GS396_RS03105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GS396_RS03110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GS396_RS03115	COG1181	Belongs to the D-alanine--D-alanine ligase family
GS396_RS03120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GS396_RS03130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GS396_RS03135	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GS396_RS03145	COG0739	heme binding
GS396_RS03150	COG0653	protein targeting
GS396_RS03155	COG0494	nUDIX hydrolase
GS396_RS03165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GS396_RS03170	COG2267	carboxylic ester hydrolase activity
GS396_RS03175	COG3275	phosphorelay sensor kinase activity
GS396_RS03185	COG0402	S-adenosylhomocysteine deaminase activity
GS396_RS03205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GS396_RS03210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GS396_RS03220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GS396_RS03225	COG1607	acyl-coa hydrolase
GS396_RS03230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GS396_RS03250	COG4106	trans-aconitate 2-methyltransferase activity
GS396_RS03255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GS396_RS03275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GS396_RS03280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GS396_RS03285	COG0667	Aldo Keto reductase
GS396_RS03295	COG4771	TonB-dependent receptor
GS396_RS03310	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GS396_RS03315	COG4181	ATPase activity
GS396_RS03330	COG0642	Histidine kinase
GS396_RS03340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GS396_RS03345	COG0861	Integral membrane protein TerC family
GS396_RS03350	COG2814	Major facilitator Superfamily
GS396_RS03355	COG1704	LemA family
GS396_RS03370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GS396_RS03375	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GS396_RS03390	COG3738	Protein conserved in bacteria
GS396_RS03395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GS396_RS03400	COG2967	ApaG domain
GS396_RS03410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GS396_RS03415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GS396_RS03420	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GS396_RS03430	COG2096	Adenosyltransferase
GS396_RS03440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GS396_RS03445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GS396_RS03450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GS396_RS03455	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GS396_RS03475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GS396_RS03485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GS396_RS03495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GS396_RS03500	COG0583	DNA-binding transcription factor activity
GS396_RS03505	COG3634	alkyl hydroperoxide reductase activity
GS396_RS03565	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GS396_RS03585	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GS396_RS03590	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GS396_RS03605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GS396_RS03625	COG1404	Belongs to the peptidase S8 family
GS396_RS03645	COG1295	ribonuclease BN
GS396_RS03650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GS396_RS03665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GS396_RS03670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GS396_RS03685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GS396_RS03695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GS396_RS03700	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GS396_RS03705	COG0193	aminoacyl-tRNA hydrolase activity
GS396_RS03710	COG0012	GTP binding
GS396_RS03715	COG4206	TonB-dependent receptor
GS396_RS03720	COG4242	Belongs to the peptidase S51 family
GS396_RS03745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GS396_RS03755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GS396_RS03760	COG0250	Participates in transcription elongation, termination and antitermination
GS396_RS03765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GS396_RS03770	COG0081	regulation of translation
GS396_RS03775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GS396_RS03780	COG0222	ribosome binding
GS396_RS03785	COG0085	RNA polymerase activity
GS396_RS03790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GS396_RS03795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GS396_RS03800	COG0049	tRNA binding
GS396_RS03805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GS396_RS03810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GS396_RS03815	COG0051	transcription antitermination factor activity, RNA binding
GS396_RS03820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GS396_RS03825	COG0088	Forms part of the polypeptide exit tunnel
GS396_RS03830	COG0089	rRNA binding
GS396_RS03835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GS396_RS03840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GS396_RS03845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GS396_RS03850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GS396_RS03855	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GS396_RS03860	COG0255	Belongs to the universal ribosomal protein uL29 family
GS396_RS03865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GS396_RS03870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GS396_RS03875	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GS396_RS03880	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GS396_RS03885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GS396_RS03890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GS396_RS03895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GS396_RS03900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GS396_RS03905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GS396_RS03910	COG1841	ribosomal large subunit assembly
GS396_RS03915	COG0200	Binds to the 23S rRNA
GS396_RS03920	COG0201	protein transport
GS396_RS03925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GS396_RS03930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GS396_RS03935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GS396_RS03940	COG0202	RNA polymerase activity
GS396_RS03945	COG0203	ribosomal protein L17
GS396_RS03960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GS396_RS03970	COG0154	amidase activity
GS396_RS03985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GS396_RS03990	COG0039	L-malate dehydrogenase activity
GS396_RS04000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GS396_RS04015	COG0625	glutathione transferase activity
GS396_RS04025	COG1902	pentaerythritol trinitrate reductase activity
GS396_RS04025	COG0446	pyridine nucleotide-disulphide oxidoreductase
GS396_RS04030	COG2364	Membrane
GS396_RS04035	COG0604	alcohol dehydrogenase
GS396_RS04050	COG1187	pseudouridine synthase activity
GS396_RS04070	COG1063	alcohol dehydrogenase
GS396_RS04110	COG0588	phosphoglycerate mutase activity
GS396_RS04115	COG0285	dihydrofolate synthase activity
GS396_RS04135	COG2833	Protein of unknown function (DUF455)
GS396_RS04145	COG3291	Pkd domain containing protein
GS396_RS04150	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GS396_RS04160	COG0438	transferase activity, transferring glycosyl groups
GS396_RS04165	COG0248	Ppx GppA phosphatase
GS396_RS04170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GS396_RS04185	COG4783	chaperone-mediated protein folding
GS396_RS04200	COG0473	3-isopropylmalate dehydrogenase activity
GS396_RS04270	COG0544	peptidyl-prolyl cis-trans isomerase activity
GS396_RS04275	COG0740	serine-type endopeptidase activity
GS396_RS04280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GS396_RS04320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GS396_RS04325	COG1388	LysM domain
GS396_RS04325	COG3942	CHAP domain
GS396_RS04330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GS396_RS04340	COG0328	RNA-DNA hybrid ribonuclease activity
GS396_RS04345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GS396_RS04350	COG0631	protein serine/threonine phosphatase activity
GS396_RS04365	COG0859	PFAM glycosyl transferase family 9
GS396_RS04370	COG3642	lipopolysaccharide core region biosynthetic process
GS396_RS04375	COG1234	tRNA 3'-trailer cleavage
GS396_RS04390	COG2076	Multidrug Resistance protein
GS396_RS04410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GS396_RS04415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GS396_RS04425	COG0537	adenosine 5'-monophosphoramidase activity
GS396_RS04445	COG0714	Associated with various cellular activities
GS396_RS04460	COG1399	metal-binding, possibly nucleic acid-binding protein
GS396_RS04465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GS396_RS04470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GS396_RS04480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GS396_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS04495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GS396_RS04500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GS396_RS04505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GS396_RS04510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GS396_RS04555	COG4774	siderophore transport
GS396_RS04565	COG2223	nitrite transmembrane transporter activity
GS396_RS04580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GS396_RS04590	COG0583	DNA-binding transcription factor activity
GS396_RS04595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GS396_RS04600	COG0697	spore germination
GS396_RS04605	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS04610	COG0583	DNA-binding transcription factor activity
GS396_RS04615	COG0583	DNA-binding transcription factor activity
GS396_RS04620	COG0477	Major facilitator Superfamily
GS396_RS04630	COG2205	protein histidine kinase activity
GS396_RS04640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS04680	COG0583	DNA-binding transcription factor activity
GS396_RS04690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GS396_RS04705	COG0667	Aldo Keto reductase
GS396_RS04720	COG0456	acetyltransferase
GS396_RS04730	COG0519	Catalyzes the synthesis of GMP from XMP
GS396_RS04735	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GS396_RS04740	COG1678	Uncharacterized ACR, COG1678
GS396_RS04745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GS396_RS04750	COG0540	Belongs to the ATCase OTCase family
GS396_RS04770	COG2239	Acts as a magnesium transporter
GS396_RS04775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GS396_RS04790	COG1660	Displays ATPase and GTPase activities
GS396_RS04795	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GS396_RS04800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GS396_RS04805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GS396_RS04815	COG1137	ATPase activity
GS396_RS04830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GS396_RS04845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GS396_RS04865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GS396_RS04885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GS396_RS04895	COG0628	permease
GS396_RS04905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GS396_RS04915	COG2261	transglycosylase associated protein
GS396_RS04925	COG1555	photosystem II stabilization
GS396_RS04950	COG1477	protein flavinylation
GS396_RS04970	COG4771	TonB-dependent receptor
GS396_RS04980	COG3128	pkhd-type hydroxylase
GS396_RS04990	COG4774	siderophore transport
GS396_RS05015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GS396_RS05020	COG0719	Fe-S assembly protein
GS396_RS05025	COG0396	ATPase activity
GS396_RS05030	COG0719	Fe-S assembly protein
GS396_RS05035	COG1959	2 iron, 2 sulfur cluster binding
GS396_RS05045	COG0693	protein deglycase activity
GS396_RS05070	COG1764	response to oxidative stress
GS396_RS05075	COG0384	phenazine biosynthesis protein PhzF
GS396_RS05080	COG0384	phenazine biosynthesis protein PhzF
GS396_RS05085	COG0527	aspartate kinase activity
GS396_RS05095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GS396_RS05110	COG0142	geranyltranstransferase activity
GS396_RS05115	COG0366	Alpha amylase catalytic
GS396_RS05125	COG1082	Xylose isomerase domain protein TIM barrel
GS396_RS05135	COG2190	(PTS) system
GS396_RS05135	COG2211	Major facilitator Superfamily
GS396_RS05160	COG1131	(ABC) transporter
GS396_RS05175	COG0629	single-stranded DNA binding
GS396_RS05180	COG0583	DNA-binding transcription factor activity
GS396_RS05215	COG2010	Cytochrome c
GS396_RS05225	COG0673	inositol 2-dehydrogenase activity
GS396_RS05230	COG2211	Major facilitator Superfamily
GS396_RS05240	COG1609	Transcriptional regulator
GS396_RS05275	COG3655	Transcriptional regulator
GS396_RS05280	COG1253	flavin adenine dinucleotide binding
GS396_RS05285	COG1408	metallophosphoesterase
GS396_RS05290	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GS396_RS05310	COG2259	Doxx family
GS396_RS05325	COG0745	RESPONSE REGULATOR receiver
GS396_RS05335	COG0477	Major facilitator Superfamily
GS396_RS05350	COG1802	Transcriptional regulator
GS396_RS05365	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GS396_RS05385	COG3052	prosthetic group binding
GS396_RS05400	COG0579	oxidoreductase
GS396_RS05425	COG3104	oligopeptide transport
GS396_RS05435	COG1297	OPT oligopeptide transporter protein
GS396_RS05440	COG1506	peptidase
GS396_RS05440	COG0823	Involved in the tonB-independent uptake of proteins
GS396_RS05455	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GS396_RS05460	COG2894	cell division
GS396_RS05475	COG4585	Histidine kinase
GS396_RS05480	COG2197	response regulator
GS396_RS05520	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GS396_RS05530	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GS396_RS05540	COG1595	DNA-templated transcription, initiation
GS396_RS05550	COG1946	Acyl-CoA thioesterase
GS396_RS05570	COG0824	Thioesterase
GS396_RS05575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GS396_RS05580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GS396_RS05585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GS396_RS05590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GS396_RS05595	COG0268	Binds directly to 16S ribosomal RNA
GS396_RS05600	COG0728	peptidoglycan biosynthetic process
GS396_RS05605	COG0196	riboflavin kinase activity
GS396_RS05610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GS396_RS05620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GS396_RS05645	COG4206	TonB-dependent receptor
GS396_RS05665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GS396_RS05695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GS396_RS05700	COG1845	cytochrome c oxidase, subunit III
GS396_RS05705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GS396_RS05720	COG0326	Molecular chaperone. Has ATPase activity
GS396_RS05740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GS396_RS05755	COG0228	four-way junction DNA binding
GS396_RS05760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GS396_RS05765	COG0336	Belongs to the RNA methyltransferase TrmD family
GS396_RS05770	COG0335	large ribosomal subunit rRNA binding
GS396_RS05790	COG0534	Mate efflux family protein
GS396_RS05815	COG0753	catalase activity
GS396_RS05840	COG0840	transmembrane signaling receptor activity
GS396_RS05845	COG3134	Outer membrane lipoprotein
GS396_RS05860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS05885	COG0024	Methionine aminopeptidase
GS396_RS05935	COG1647	Serine aminopeptidase, S33
GS396_RS05955	COG1733	regulation of RNA biosynthetic process
GS396_RS05960	COG2814	Major facilitator Superfamily
GS396_RS05965	COG3706	GGDEF domain
GS396_RS05985	COG0588	phosphoglycerate mutase activity
GS396_RS05990	COG3590	peptidase
GS396_RS06000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GS396_RS06010	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GS396_RS06015	COG0745	RESPONSE REGULATOR receiver
GS396_RS06020	COG2205	protein histidine kinase activity
GS396_RS06025	COG4452	Inner membrane protein CreD
GS396_RS06040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GS396_RS06045	COG0735	belongs to the Fur family
GS396_RS06110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GS396_RS06125	COG5001	Diguanylate cyclase
GS396_RS06125	COG5002	protein histidine kinase activity
GS396_RS06130	COG3706	GGDEF domain
GS396_RS06130	COG0745	RESPONSE REGULATOR receiver
GS396_RS06135	COG1187	pseudouridine synthase activity
GS396_RS06140	COG3706	GGDEF domain
GS396_RS06145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GS396_RS06165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GS396_RS06170	COG1132	(ABC) transporter
GS396_RS06210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GS396_RS06215	COG1695	Transcriptional regulator
GS396_RS06240	COG0825	malonyl-CoA metabolic process
GS396_RS06265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GS396_RS06275	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GS396_RS06285	COG0750	zinc metalloprotease
GS396_RS06290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GS396_RS06295	COG0575	Belongs to the CDS family
GS396_RS06300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GS396_RS06305	COG0233	cytoplasmic translational termination
GS396_RS06315	COG3706	GGDEF domain
GS396_RS06320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GS396_RS06325	COG0052	Belongs to the universal ribosomal protein uS2 family
GS396_RS06345	COG3188	usher protein
GS396_RS06360	COG0024	Methionine aminopeptidase
GS396_RS06365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GS396_RS06380	COG1393	Belongs to the ArsC family
GS396_RS06385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GS396_RS06395	COG0367	asparagine synthase
GS396_RS06400	COG0475	glutathione-regulated potassium exporter activity
GS396_RS06435	COG1566	PFAM secretion protein HlyD family protein
GS396_RS06440	COG2814	Major facilitator Superfamily
GS396_RS06455	COG0583	DNA-binding transcription factor activity
GS396_RS06485	COG0557	exoribonuclease II activity
GS396_RS06495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GS396_RS06500	COG1538	Outer membrane efflux protein
GS396_RS06505	COG1136	(ABC) transporter
GS396_RS06505	COG0577	efflux transmembrane transporter activity
GS396_RS06510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS06515	COG0745	RESPONSE REGULATOR receiver
GS396_RS06525	COG3706	GGDEF domain
GS396_RS06530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GS396_RS06535	COG2259	Doxx family
GS396_RS06545	COG3220	belongs to the UPF0276 family
GS396_RS06555	COG0704	Plays a role in the regulation of phosphate uptake
GS396_RS06565	COG0581	inorganic phosphate transmembrane transporter activity
GS396_RS06570	COG0573	inorganic phosphate transmembrane transporter activity
GS396_RS06575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GS396_RS06580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GS396_RS06590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GS396_RS06600	COG1024	Enoyl-CoA hydratase
GS396_RS06630	COG0116	Belongs to the methyltransferase superfamily
GS396_RS06630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GS396_RS06650	COG2733	membrane
GS396_RS06665	COG1012	belongs to the aldehyde dehydrogenase family
GS396_RS06680	COG0477	Major facilitator Superfamily
GS396_RS06685	COG2703	oxygen carrier activity
GS396_RS06690	COG0745	RESPONSE REGULATOR receiver
GS396_RS06690	COG3706	GGDEF domain
GS396_RS06710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GS396_RS06715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GS396_RS06720	COG0174	glutamine synthetase
GS396_RS06730	COG2072	flavoprotein involved in K transport
GS396_RS06735	COG3842	ATPase activity
GS396_RS06740	COG1176	ABC-type spermidine putrescine transport system, permease component I
GS396_RS06745	COG1177	transmembrane transport
GS396_RS06750	COG1012	belongs to the aldehyde dehydrogenase family
GS396_RS06765	COG4535	Mg2 and Co2 transporter CorC
GS396_RS06785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GS396_RS06790	COG1702	phosphate starvation-inducible protein PhoH
GS396_RS06800	COG1131	(ABC) transporter
GS396_RS06805	COG0842	Transport permease protein
GS396_RS06810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GS396_RS06825	COG0741	lytic transglycosylase activity
GS396_RS06830	COG0723	plastoquinol--plastocyanin reductase activity
GS396_RS06835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GS396_RS06840	COG2857	Cytochrome c1
GS396_RS06845	COG0625	glutathione transferase activity
GS396_RS06850	COG2969	positive regulation of protein catabolic process
GS396_RS06885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GS396_RS06895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GS396_RS06910	COG1611	Belongs to the LOG family
GS396_RS06955	COG0556	nucleotide-excision repair
GS396_RS06980	COG3713	MltA-interacting MipA family protein
GS396_RS06990	COG2205	protein histidine kinase activity
GS396_RS07000	COG0811	peptide transport
GS396_RS07005	COG0848	biopolymer transport protein
GS396_RS07015	COG1663	tetraacyldisaccharide 4'-kinase activity
GS396_RS07020	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GS396_RS07025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GS396_RS07035	COG0322	excinuclease ABC activity
GS396_RS07075	COG0577	efflux transmembrane transporter activity
GS396_RS07075	COG1136	(ABC) transporter
GS396_RS07140	COG0456	acetyltransferase
GS396_RS07150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GS396_RS07190	COG4977	sequence-specific DNA binding
GS396_RS07190	COG1917	Cupin 2, conserved barrel domain protein
GS396_RS07195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GS396_RS07215	COG0348	domain, Protein
GS396_RS07230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GS396_RS07245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GS396_RS07250	COG0069	glutamate synthase activity
GS396_RS07280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GS396_RS07295	COG1253	flavin adenine dinucleotide binding
GS396_RS07305	COG0306	phosphate transporter
GS396_RS07315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GS396_RS07330	COG0504	CTP synthase activity
GS396_RS07335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GS396_RS07350	COG0148	phosphopyruvate hydratase activity
GS396_RS07355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GS396_RS07360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GS396_RS07365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GS396_RS07375	COG2840	Smr protein MutS2
GS396_RS07380	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GS396_RS07385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GS396_RS07405	COG1534	Rna-binding protein
GS396_RS07410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GS396_RS07415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GS396_RS07425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GS396_RS07430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GS396_RS07435	COG1923	regulation of RNA biosynthetic process
GS396_RS07440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GS396_RS07445	COG1546	Belongs to the CinA family
GS396_RS07450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GS396_RS07455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GS396_RS07460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GS396_RS07465	COG2137	regulation of response to DNA damage stimulus
GS396_RS07470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GS396_RS07475	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GS396_RS07500	COG4773	Receptor
GS396_RS07515	COG1940	carbohydrate kinase activity
GS396_RS07555	COG3540	Alkaline phosphatase
GS396_RS07570	COG3258	Cytochrome c
GS396_RS07585	COG2223	nitrite transmembrane transporter activity
GS396_RS07600	COG1741	Belongs to the pirin family
GS396_RS07605	COG0583	DNA-binding transcription factor activity
GS396_RS07630	COG0351	phosphomethylpyrimidine kinase
GS396_RS07630	COG0352	thiamine-phosphate diphosphorylase activity
GS396_RS07645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GS396_RS07650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GS396_RS07660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GS396_RS07670	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GS396_RS07675	COG0477	Major facilitator Superfamily
GS396_RS07685	COG0617	tRNA 3'-terminal CCA addition
GS396_RS07690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GS396_RS07695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GS396_RS07700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GS396_RS07710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GS396_RS07715	COG0166	Belongs to the GPI family
GS396_RS07730	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GS396_RS07740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GS396_RS07745	COG0671	phosphoesterase, PA-phosphatase related
GS396_RS07755	COG0800	Aldolase
GS396_RS07760	COG0129	dihydroxy-acid dehydratase activity
GS396_RS07770	COG0837	glucose binding
GS396_RS07775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GS396_RS07795	COG2009	succinate dehydrogenase
GS396_RS07800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GS396_RS07805	COG1053	succinate dehydrogenase
GS396_RS07825	COG4591	ABC-type transport system involved in lipoprotein release permease component
GS396_RS07840	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GS396_RS07845	COG1194	a g-specific adenine glycosylase
GS396_RS07850	COG0552	protein localization to endoplasmic reticulum
GS396_RS07865	COG0742	ribosomal rna small subunit methyltransferase
GS396_RS07870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GS396_RS07880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GS396_RS07885	COG0405	Gamma-glutamyltransferase
GS396_RS07890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GS396_RS07910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GS396_RS07930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GS396_RS07935	COG0415	Belongs to the DNA photolyase family
GS396_RS07940	COG2885	chlorophyll binding
GS396_RS07945	COG0583	DNA-binding transcription factor activity
GS396_RS08010	COG0693	protein deglycase activity
GS396_RS08015	COG1917	Cupin 2, conserved barrel domain protein
GS396_RS08015	COG4977	sequence-specific DNA binding
GS396_RS08040	COG1404	Belongs to the peptidase S8 family
GS396_RS08075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GS396_RS08085	COG2914	Belongs to the UPF0125 (RnfH) family
GS396_RS08090	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GS396_RS08095	COG0735	belongs to the Fur family
GS396_RS08105	COG0583	DNA-binding transcription factor activity
GS396_RS08110	COG0497	DNA recombination
GS396_RS08115	COG1420	regulation of RNA biosynthetic process
GS396_RS08120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GS396_RS08125	COG0443	Heat shock 70 kDa protein
GS396_RS08130	COG0484	heat shock protein binding
GS396_RS08135	COG2207	Transcriptional regulator
GS396_RS08140	COG2223	nitrite transmembrane transporter activity
GS396_RS08145	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GS396_RS08150	COG0287	Prephenate dehydrogenase
GS396_RS08150	COG1605	Chorismate mutase
GS396_RS08160	COG1132	(ABC) transporter
GS396_RS08180	COG5001	Diguanylate cyclase
GS396_RS08190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GS396_RS08195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GS396_RS08200	COG0343	queuine tRNA-ribosyltransferase activity
GS396_RS08205	COG1862	Preprotein translocase
GS396_RS08215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GS396_RS08220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GS396_RS08230	COG2081	HI0933 family
GS396_RS08235	COG4681	YaeQ
GS396_RS08255	COG0625	glutathione transferase activity
GS396_RS08260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GS396_RS08270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GS396_RS08275	COG0513	Belongs to the DEAD box helicase family
GS396_RS08285	COG0583	DNA-binding transcription factor activity
GS396_RS08315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GS396_RS08330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GS396_RS08335	COG2957	Belongs to the agmatine deiminase family
GS396_RS08345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GS396_RS08350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GS396_RS08360	COG0776	regulation of translation
GS396_RS08370	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GS396_RS08385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GS396_RS08390	COG0183	Belongs to the thiolase family
GS396_RS08395	COG1024	Enoyl-CoA hydratase
GS396_RS08395	COG1250	3-hydroxyacyl-CoA dehydrogenase
GS396_RS08405	COG0105	UTP biosynthetic process
GS396_RS08410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GS396_RS08420	COG1426	Protein conserved in bacteria
GS396_RS08425	COG2976	Protein conserved in bacteria
GS396_RS08430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GS396_RS08435	COG1160	GTP binding
GS396_RS08445	COG0583	DNA-binding transcription factor activity
GS396_RS08450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GS396_RS08455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GS396_RS08455	COG0475	glutathione-regulated potassium exporter activity
GS396_RS08475	COG0519	Catalyzes the synthesis of GMP from XMP
GS396_RS08475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GS396_RS08485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GS396_RS08495	COG0583	DNA-binding transcription factor activity
GS396_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS08545	COG0596	Alpha beta hydrolase
GS396_RS08560	COG0640	Transcriptional regulator
GS396_RS08590	COG0431	NADPH-dependent FMN reductase
GS396_RS08600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GS396_RS08605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GS396_RS08610	COG1473	amidohydrolase
GS396_RS08645	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GS396_RS08650	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS08670	COG1309	transcriptional regulator
GS396_RS08685	COG0697	spore germination
GS396_RS08690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GS396_RS08695	COG0167	dihydroorotate dehydrogenase activity
GS396_RS08710	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS08715	COG1012	belongs to the aldehyde dehydrogenase family
GS396_RS08730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GS396_RS08770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GS396_RS08805	COG4191	Histidine kinase
GS396_RS08805	COG0784	Response regulator, receiver
GS396_RS08810	COG4999	Histidine kinase
GS396_RS08810	COG3850	Histidine kinase
GS396_RS08810	COG3437	response regulator, receiver
GS396_RS08810	COG2205	protein histidine kinase activity
GS396_RS08815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GS396_RS08825	COG5002	protein histidine kinase activity
GS396_RS08835	COG0640	Transcriptional regulator
GS396_RS08885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GS396_RS08890	COG0124	histidyl-tRNA synthetase
GS396_RS08900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GS396_RS08905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GS396_RS08910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GS396_RS08915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GS396_RS08915	COG0131	Imidazoleglycerol-phosphate dehydratase
GS396_RS08920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GS396_RS08925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GS396_RS08930	COG0107	imidazoleglycerol-phosphate synthase activity
GS396_RS08935	COG0140	phosphoribosyl-ATP diphosphatase activity
GS396_RS08935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GS396_RS08955	COG1446	asparaginase
GS396_RS08960	COG3142	Participates in the control of copper homeostasis
GS396_RS08975	COG0789	Transcriptional regulator
GS396_RS08990	COG3537	Alpha-1,2-mannosidase
GS396_RS08995	COG1609	Transcriptional regulator
GS396_RS09005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GS396_RS09020	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
GS396_RS09025	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GS396_RS09030	COG0235	Class ii aldolase
GS396_RS09040	COG0531	amino acid
GS396_RS09045	COG0531	amino acid
GS396_RS09055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GS396_RS09060	COG0277	FAD linked oxidase domain protein
GS396_RS09075	COG2205	protein histidine kinase activity
GS396_RS09080	COG0745	RESPONSE REGULATOR receiver
GS396_RS09085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS09090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GS396_RS09105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GS396_RS09150	COG2249	NAD(P)H dehydrogenase (quinone) activity
GS396_RS09165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GS396_RS09170	COG0505	Belongs to the CarA family
GS396_RS09175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GS396_RS09180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GS396_RS09190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GS396_RS09195	COG4676	Protein conserved in bacteria
GS396_RS09205	COG3279	Response regulator of the LytR AlgR family
GS396_RS09220	COG1012	belongs to the aldehyde dehydrogenase family
GS396_RS09240	COG2198	Histidine kinase
GS396_RS09240	COG0784	Response regulator, receiver
GS396_RS09240	COG2205	protein histidine kinase activity
GS396_RS09245	COG1024	Enoyl-CoA hydratase
GS396_RS09250	COG0318	PFAM AMP-dependent synthetase and ligase
GS396_RS09255	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GS396_RS09260	COG1012	belongs to the aldehyde dehydrogenase family
GS396_RS09265	COG1309	transcriptional regulator
GS396_RS09270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GS396_RS09300	COG2201	protein-glutamate methylesterase activity
GS396_RS09305	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GS396_RS09315	COG0840	transmembrane signaling receptor activity
GS396_RS09320	COG0840	transmembrane signaling receptor activity
GS396_RS09330	COG0835	chemotaxis
GS396_RS09335	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GS396_RS09340	COG0840	transmembrane signaling receptor activity
GS396_RS09350	COG0745	RESPONSE REGULATOR receiver
GS396_RS09360	COG0835	chemotaxis
GS396_RS09365	COG1192	Involved in chromosome partitioning
GS396_RS09370	COG1360	Flagellar Motor Protein
GS396_RS09375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GS396_RS09380	COG2198	Histidine kinase
GS396_RS09380	COG0643	Histidine kinase
GS396_RS09385	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GS396_RS09400	COG0455	bacterial-type flagellum organization
GS396_RS09410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GS396_RS09415	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GS396_RS09435	COG1987	bacterial-type flagellum assembly
GS396_RS09445	COG3190	flagellar
GS396_RS09495	COG1677	Flagellar hook-basal body complex protein FliE
GS396_RS09500	COG2204	response regulator
GS396_RS09515	COG2197	response regulator
GS396_RS09555	COG1256	bacterial-type flagellum assembly
GS396_RS09570	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GS396_RS09575	COG4786	Flagellar basal body rod
GS396_RS09580	COG4787	bacterial-type flagellum-dependent cell motility
GS396_RS09585	COG1749	Flagellar hook protein flgE
GS396_RS09595	COG1558	bacterial-type flagellum-dependent cell motility
GS396_RS09600	COG1815	bacterial-type flagellum-dependent cell motility
GS396_RS09605	COG0784	Response regulator, receiver
GS396_RS09605	COG0835	chemotaxis
GS396_RS09625	COG5002	protein histidine kinase activity
GS396_RS09660	COG2915	High frequency lysogenization protein hflD homolog
GS396_RS09665	COG0482	sulfurtransferase activity
GS396_RS09680	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GS396_RS09690	COG0542	response to heat
GS396_RS09705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GS396_RS09725	COG0492	ferredoxin-NADP+ reductase activity
GS396_RS09730	COG1674	ftsk spoiiie
GS396_RS09740	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GS396_RS09745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GS396_RS09760	COG2819	hydrolase of the alpha beta superfamily
GS396_RS09770	COG4558	Periplasmic binding protein
GS396_RS09775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GS396_RS09780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GS396_RS09790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GS396_RS09805	COG5002	protein histidine kinase activity
GS396_RS09805	COG0784	Response regulator, receiver
GS396_RS09840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GS396_RS09850	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GS396_RS09865	COG1595	DNA-templated transcription, initiation
GS396_RS09885	COG0784	Response regulator, receiver
GS396_RS09890	COG4251	negative regulation of phosphorylation
GS396_RS09900	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GS396_RS10005	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GS396_RS10010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GS396_RS10015	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GS396_RS10020	COG2080	2 iron, 2 sulfur cluster binding
GS396_RS10035	COG1309	transcriptional regulator
GS396_RS10100	COG1609	Transcriptional regulator
GS396_RS10105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GS396_RS10105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GS396_RS10110	COG1105	Belongs to the carbohydrate kinase PfkB family
GS396_RS10115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GS396_RS10115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GS396_RS10135	COG2211	Major facilitator Superfamily
GS396_RS10140	COG1472	Belongs to the glycosyl hydrolase 3 family
GS396_RS10155	COG3661	Belongs to the glycosyl hydrolase 67 family
GS396_RS10165	COG1472	Belongs to the glycosyl hydrolase 3 family
GS396_RS10170	COG0477	Major facilitator Superfamily
GS396_RS10180	COG1070	Carbohydrate kinase
GS396_RS10205	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GS396_RS10230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GS396_RS10245	COG2828	Protein conserved in bacteria
GS396_RS10250	COG0583	DNA-binding transcription factor activity
GS396_RS10260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GS396_RS10265	COG0583	DNA-binding transcription factor activity
GS396_RS10280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GS396_RS10315	COG0642	Histidine kinase
GS396_RS10325	COG0318	PFAM AMP-dependent synthetase and ligase
GS396_RS10335	COG5265	(ABC) transporter
GS396_RS10340	COG4206	TonB-dependent receptor
GS396_RS10375	COG2186	Transcriptional regulator
GS396_RS10395	COG2271	Major facilitator Superfamily
GS396_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS10435	COG1404	Belongs to the peptidase S8 family
GS396_RS10450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GS396_RS10465	COG2226	methyltransferase
GS396_RS10475	COG0583	DNA-binding transcription factor activity
GS396_RS10500	COG2204	response regulator
GS396_RS10565	COG5002	protein histidine kinase activity
GS396_RS10565	COG3447	MASE1 domain protein
GS396_RS10565	COG5001	Diguanylate cyclase
GS396_RS10570	COG1136	(ABC) transporter
GS396_RS10570	COG0577	efflux transmembrane transporter activity
GS396_RS10575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS10585	COG0745	RESPONSE REGULATOR receiver
GS396_RS10590	COG2205	protein histidine kinase activity
GS396_RS10600	COG3214	Protein conserved in bacteria
GS396_RS10610	COG4774	siderophore transport
GS396_RS10635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GS396_RS10640	COG1285	pathogenesis
GS396_RS10645	COG4191	Histidine kinase
GS396_RS10650	COG4566	intracellular signal transduction
GS396_RS10655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GS396_RS10660	COG1215	transferase activity, transferring glycosyl groups
GS396_RS10720	COG2197	response regulator
GS396_RS10725	COG2197	response regulator
GS396_RS10730	COG2205	protein histidine kinase activity
GS396_RS10730	COG0784	Response regulator, receiver
GS396_RS10775	COG0243	molybdopterin cofactor binding
GS396_RS10800	COG0477	Major facilitator Superfamily
GS396_RS10825	COG1136	(ABC) transporter
GS396_RS10840	COG0583	DNA-binding transcription factor activity
GS396_RS10880	COG5002	protein histidine kinase activity
GS396_RS10885	COG0583	DNA-binding transcription factor activity
GS396_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS10920	COG0642	Histidine kinase
GS396_RS10925	COG3537	Alpha-1,2-mannosidase
GS396_RS10930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GS396_RS10945	COG0477	Major facilitator Superfamily
GS396_RS10960	COG2202	Pas domain
GS396_RS10960	COG3920	Histidine kinase
GS396_RS11025	COG0811	peptide transport
GS396_RS11145	COG0840	transmembrane signaling receptor activity
GS396_RS11160	COG4149	molybdate abc transporter
GS396_RS11165	COG0725	ABC transporter, periplasmic molybdate-binding protein
GS396_RS11170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GS396_RS11185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GS396_RS11190	COG2181	nitrate reductase activity
GS396_RS11195	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GS396_RS11200	COG1140	nitrate reductase beta subunit
GS396_RS11205	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GS396_RS11210	COG2223	nitrite transmembrane transporter activity
GS396_RS11220	COG0746	molybdenum cofactor guanylyltransferase activity
GS396_RS11225	COG0314	molybdopterin synthase activity
GS396_RS11235	COG0303	'Molybdopterin
GS396_RS11240	COG0315	cyclic pyranopterin monophosphate synthase activity
GS396_RS11240	COG0521	Mo-molybdopterin cofactor biosynthetic process
GS396_RS11245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GS396_RS11280	COG2207	Transcriptional regulator
GS396_RS11320	COG2205	protein histidine kinase activity
GS396_RS11330	COG2194	sulfuric ester hydrolase activity
GS396_RS11350	COG2885	chlorophyll binding
GS396_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS11375	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GS396_RS11375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GS396_RS11380	COG1535	isochorismatase
GS396_RS11380	COG3433	isochorismatase activity
GS396_RS11385	COG1535	isochorismatase
GS396_RS11385	COG3433	isochorismatase activity
GS396_RS11390	COG1021	2,3-dihydroxybenzoate-AMP ligase
GS396_RS11395	COG1169	isochorismate synthase
GS396_RS11405	COG2409	Drug exporters of the RND superfamily
GS396_RS11410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GS396_RS11465	COG1321	iron dependent repressor
GS396_RS11470	COG1914	H( )-stimulated, divalent metal cation uptake system
GS396_RS11485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GS396_RS11490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GS396_RS11500	COG4206	TonB-dependent receptor
GS396_RS11505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GS396_RS11540	COG0583	DNA-binding transcription factor activity
GS396_RS11550	COG4772	TonB-dependent receptor
GS396_RS11570	COG2226	methyltransferase
GS396_RS11615	COG4964	Belongs to the GSP D family
GS396_RS11670	COG2814	Major facilitator Superfamily
GS396_RS11680	COG1228	amidohydrolase
GS396_RS11690	COG1335	isochorismatase
GS396_RS11705	COG3850	Histidine kinase
GS396_RS11710	COG2197	response regulator
GS396_RS11715	COG2814	Major facilitator Superfamily
GS396_RS11725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GS396_RS11735	COG0583	DNA-binding transcription factor activity
GS396_RS11750	COG3161	chorismate lyase activity
GS396_RS11790	COG0277	FAD linked oxidase domain protein
GS396_RS11795	COG1304	FMN binding
GS396_RS11800	COG2186	Transcriptional regulator
GS396_RS11810	COG1285	pathogenesis
GS396_RS11835	COG2814	Major facilitator Superfamily
GS396_RS11890	COG0587	DNA-directed DNA polymerase activity
GS396_RS11905	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GS396_RS11910	COG0519	Catalyzes the synthesis of GMP from XMP
GS396_RS11910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GS396_RS11925	COG1595	DNA-templated transcription, initiation
GS396_RS11935	COG1629	transport
GS396_RS11935	COG4206	TonB-dependent receptor
GS396_RS11960	COG1982	Orn Lys Arg decarboxylase major
GS396_RS11965	COG0531	amino acid
GS396_RS11980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GS396_RS11990	COG0789	Transcriptional regulator
GS396_RS12055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GS396_RS12085	COG5002	protein histidine kinase activity
GS396_RS12085	COG5001	Diguanylate cyclase
GS396_RS12085	COG3447	MASE1 domain protein
GS396_RS12090	COG2183	response to ionizing radiation
GS396_RS12115	COG3243	poly(R)-hydroxyalkanoic acid synthase
GS396_RS12135	COG0534	Mate efflux family protein
GS396_RS12155	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GS396_RS12165	COG0668	transmembrane transport
GS396_RS12170	COG1902	pentaerythritol trinitrate reductase activity
GS396_RS12180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GS396_RS12185	COG0590	tRNA wobble adenosine to inosine editing
GS396_RS12190	COG1733	regulation of RNA biosynthetic process
GS396_RS12195	COG2249	NAD(P)H dehydrogenase (quinone) activity
GS396_RS12200	COG0456	acetyltransferase
GS396_RS12275	COG3702	type iv secretory pathway
GS396_RS12295	COG2948	multi-organism process
GS396_RS12305	COG3736	Type IV secretory pathway, component VirB8
GS396_RS12325	COG2814	Major facilitator Superfamily
GS396_RS12330	COG0789	Transcriptional regulator
GS396_RS12360	COG0784	Response regulator, receiver
GS396_RS12360	COG4191	Histidine kinase
GS396_RS12375	COG4774	siderophore transport
GS396_RS12385	COG0745	RESPONSE REGULATOR receiver
GS396_RS12405	COG0577	efflux transmembrane transporter activity
GS396_RS12405	COG1136	(ABC) transporter
GS396_RS12425	COG1733	regulation of RNA biosynthetic process
GS396_RS12430	COG0604	alcohol dehydrogenase
GS396_RS12440	COG0210	DNA helicase
GS396_RS12460	COG0583	DNA-binding transcription factor activity
GS396_RS12465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GS396_RS12475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GS396_RS12490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GS396_RS12495	COG0077	Prephenate dehydratase
GS396_RS12495	COG1605	Chorismate mutase
GS396_RS12500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GS396_RS12535	COG1228	amidohydrolase
GS396_RS12550	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GS396_RS12555	COG5001	Diguanylate cyclase
GS396_RS12565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GS396_RS12610	COG2957	Belongs to the agmatine deiminase family
GS396_RS12615	COG0583	DNA-binding transcription factor activity
GS396_RS12675	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GS396_RS12685	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GS396_RS12695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GS396_RS12700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GS396_RS12720	COG0359	binds to the 23S rRNA
GS396_RS12725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GS396_RS12730	COG0360	Binds together with S18 to 16S ribosomal RNA
GS396_RS12735	COG0316	Belongs to the HesB IscA family
GS396_RS12740	COG0017	Asparaginyl-tRNA synthetase
GS396_RS12760	COG0288	reversible hydration of carbon dioxide
GS396_RS12770	COG3844	kynureninase activity
GS396_RS12775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GS396_RS12780	COG2925	Exonuclease
GS396_RS12790	COG0667	Aldo Keto reductase
GS396_RS12810	COG2902	Dehydrogenase
GS396_RS12820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS12825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GS396_RS12835	COG1960	acyl-CoA dehydrogenase activity
GS396_RS12850	COG1410	methionine synthase
GS396_RS12850	COG0646	methionine synthase
GS396_RS12880	COG0386	Belongs to the glutathione peroxidase family
GS396_RS12885	COG1725	Transcriptional regulator
GS396_RS12890	COG1131	(ABC) transporter
GS396_RS12925	COG2850	peptidyl-arginine hydroxylation
GS396_RS12935	COG0567	Dehydrogenase, E1 component
GS396_RS12960	COG3540	Alkaline phosphatase
GS396_RS12970	COG0305	Participates in initiation and elongation during chromosome replication
GS396_RS12985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GS396_RS12990	COG0625	glutathione transferase activity
GS396_RS13010	COG0084	hydrolase, TatD family'
GS396_RS13015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GS396_RS13050	COG0625	glutathione transferase activity
GS396_RS13070	COG1595	DNA-templated transcription, initiation
GS396_RS13075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GS396_RS13090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GS396_RS13095	COG0386	Belongs to the glutathione peroxidase family
GS396_RS13100	COG0339	signal peptide processing
GS396_RS13105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GS396_RS13125	COG0705	Rhomboid family
GS396_RS13145	COG4290	ribonuclease
GS396_RS13160	COG0316	Belongs to the HesB IscA family
GS396_RS13160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GS396_RS13165	COG2154	pterin-4-alpha-carbinolamine dehydratase
GS396_RS13175	COG0428	transporter
GS396_RS13185	COG1530	ribonuclease E activity
GS396_RS13200	COG0395	ABC-type sugar transport system, permease component
GS396_RS13225	COG1609	Transcriptional regulator
GS396_RS13230	COG0271	Belongs to the BolA IbaG family
GS396_RS13235	COG2350	Protein conserved in bacteria
GS396_RS13240	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GS396_RS13245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GS396_RS13250	COG1187	pseudouridine synthase activity
GS396_RS13260	COG2814	Major facilitator Superfamily
GS396_RS13280	COG0436	Aminotransferase
GS396_RS13285	COG4133	protoheme IX ABC transporter activity
GS396_RS13305	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GS396_RS13320	COG3088	subunit of a heme lyase
GS396_RS13320	COG4235	cytochrome complex assembly
GS396_RS13330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GS396_RS13340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GS396_RS13345	COG4988	ABC transporter
GS396_RS13355	COG1294	oxidase, subunit
GS396_RS13385	COG1649	PFAM Uncharacterised BCR, COG1649
GS396_RS13385	COG0726	polysaccharide deacetylase
GS396_RS13390	COG1215	transferase activity, transferring glycosyl groups
GS396_RS13400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GS396_RS13415	COG0165	Argininosuccinate lyase
GS396_RS13420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GS396_RS13430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GS396_RS13435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GS396_RS13440	COG0137	argininosuccinate synthase activity
GS396_RS13445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GS396_RS13460	COG2166	iron-sulfur cluster assembly
GS396_RS13470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GS396_RS13480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GS396_RS13500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GS396_RS13505	COG0402	S-adenosylhomocysteine deaminase activity
GS396_RS13510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GS396_RS13515	COG1509	lysine 2,3-aminomutase activity
GS396_RS13520	COG3300	MHYT domain
GS396_RS13520	COG5001	Diguanylate cyclase
GS396_RS13540	COG0501	Belongs to the peptidase M48B family
GS396_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS13570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GS396_RS13575	COG0860	N-Acetylmuramoyl-L-alanine amidase
GS396_RS13580	COG0802	atpase or kinase
GS396_RS13585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GS396_RS13585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GS396_RS13590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GS396_RS13595	COG1570	exodeoxyribonuclease VII activity
GS396_RS13605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GS396_RS13620	COG4771	TonB-dependent receptor
GS396_RS13625	COG1309	transcriptional regulator
GS396_RS13660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GS396_RS13660	COG2169	Transcriptional regulator
GS396_RS13665	COG2130	NADP-dependent
GS396_RS13690	COG1960	acyl-CoA dehydrogenase activity
GS396_RS13700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GS396_RS13730	COG1309	transcriptional regulator
GS396_RS13735	COG2076	Multidrug Resistance protein
GS396_RS13740	COG5487	UPF0391 membrane protein
GS396_RS13745	COG1280	lysine exporter protein (LysE YggA)
GS396_RS13750	COG0740	serine-type endopeptidase activity
GS396_RS13765	COG1794	racemase activity, acting on amino acids and derivatives
GS396_RS13785	COG0456	acetyltransferase
GS396_RS13785	COG0454	-acetyltransferase
GS396_RS13800	COG0776	regulation of translation
GS396_RS13805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GS396_RS13805	COG0072	phenylalanine-tRNA ligase activity
GS396_RS13810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GS396_RS13815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GS396_RS13820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GS396_RS13825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GS396_RS13830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GS396_RS13860	COG1185	polyribonucleotide nucleotidyltransferase activity
GS396_RS13865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GS396_RS13875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GS396_RS13880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GS396_RS13885	COG0195	Participates in both transcription termination and antitermination
GS396_RS13890	COG0779	Required for maturation of 30S ribosomal subunits
GS396_RS13905	COG1007	ATP synthesis coupled electron transport
GS396_RS13920	COG0713	ATP synthesis coupled electron transport
GS396_RS13930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GS396_RS13935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GS396_RS13950	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GS396_RS13955	COG0649	NAD binding
GS396_RS13960	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GS396_RS13965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GS396_RS13970	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GS396_RS13985	COG0149	triose-phosphate isomerase activity
GS396_RS14000	COG0438	transferase activity, transferring glycosyl groups
GS396_RS14005	COG0726	polysaccharide deacetylase
GS396_RS14010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GS396_RS14015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GS396_RS14020	COG0159	tryptophan synthase activity
GS396_RS14030	COG0133	tryptophan synthase activity
GS396_RS14040	COG0860	N-Acetylmuramoyl-L-alanine amidase
GS396_RS14040	COG3409	Peptidoglycan-binding domain 1 protein
GS396_RS14050	COG0135	phosphoribosylanthranilate isomerase activity
GS396_RS14055	COG0101	tRNA pseudouridine synthase activity
GS396_RS14070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GS396_RS14075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GS396_RS14080	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GS396_RS14085	COG2890	protein-(glutamine-N5) methyltransferase activity
GS396_RS14090	COG1999	signal sequence binding
GS396_RS14095	COG0688	phosphatidylethanolamine metabolic process
GS396_RS14110	COG0433	COG0433 Predicted ATPase
GS396_RS14115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GS396_RS14125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GS396_RS14130	COG0412	Dienelactone hydrolase
GS396_RS14140	COG0717	Belongs to the dCTP deaminase family
GS396_RS14145	COG0489	protein tyrosine kinase activity
GS396_RS14150	COG4771	TonB-dependent receptor
GS396_RS14155	COG4771	TonB-dependent receptor
GS396_RS14160	COG3590	peptidase
GS396_RS14200	COG0697	spore germination
GS396_RS14210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GS396_RS14215	COG2311	Membrane
GS396_RS14220	COG1047	Peptidyl-prolyl cis-trans
GS396_RS14225	COG0791	NLP P60 protein
GS396_RS14230	COG0791	NLP P60 protein
GS396_RS14235	COG1301	dicarboxylic acid transport
GS396_RS14255	COG1722	exodeoxyribonuclease VII activity
GS396_RS14260	COG0142	geranyltranstransferase activity
GS396_RS14270	COG0312	modulator of DNA gyrase
GS396_RS14275	COG3028	Belongs to the UPF0307 family
GS396_RS14280	COG0312	modulator of DNA gyrase
GS396_RS14290	COG1530	ribonuclease E activity
GS396_RS14300	COG2968	Membrane
GS396_RS14310	COG4771	TonB-dependent receptor
GS396_RS14325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GS396_RS14335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GS396_RS14350	COG0495	leucyl-tRNA aminoacylation
GS396_RS14360	COG3118	belongs to the thioredoxin family
GS396_RS14370	COG4251	negative regulation of phosphorylation
GS396_RS14370	COG2203	Gaf domain
GS396_RS14370	COG5001	Diguanylate cyclase
GS396_RS14370	COG3706	GGDEF domain
GS396_RS14395	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GS396_RS14405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GS396_RS14410	COG0346	lactoylglutathione lyase activity
GS396_RS14420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GS396_RS14420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GS396_RS14425	COG0560	Phosphoserine phosphatase
GS396_RS14430	COG2878	Part of a membrane complex involved in electron transport
GS396_RS14435	COG0251	oxidation-reduction process
GS396_RS14440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GS396_RS14440	COG0392	lysyltransferase activity
GS396_RS14470	COG2824	Alkylphosphonate utilization operon protein PhnA
GS396_RS14475	COG0443	Heat shock 70 kDa protein
GS396_RS14520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GS396_RS14525	COG3122	Protein conserved in bacteria
GS396_RS14530	COG1451	nucleotide metabolic process
GS396_RS14540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GS396_RS14560	COG0183	Belongs to the thiolase family
GS396_RS14575	COG1960	acyl-CoA dehydrogenase activity
GS396_RS14585	COG1793	dna ligase
GS396_RS14590	COG1201	RNA secondary structure unwinding
GS396_RS14605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GS396_RS14610	COG1278	Cold shock
GS396_RS14615	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GS396_RS14625	COG1472	Belongs to the glycosyl hydrolase 3 family
GS396_RS14630	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GS396_RS14640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GS396_RS14645	COG0745	RESPONSE REGULATOR receiver
GS396_RS14650	COG1381	Involved in DNA repair and RecF pathway recombination
GS396_RS14655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GS396_RS14670	COG0681	Belongs to the peptidase S26 family
GS396_RS14675	COG0481	GTPase activity
GS396_RS14680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GS396_RS14700	COG1741	Belongs to the pirin family
GS396_RS14705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GS396_RS14715	COG1741	Belongs to the pirin family
GS396_RS14720	COG1966	Carbon starvation protein
GS396_RS14725	COG2879	small protein
GS396_RS14740	COG2205	protein histidine kinase activity
GS396_RS14745	COG0745	RESPONSE REGULATOR receiver
GS396_RS14780	COG2814	Major facilitator Superfamily
GS396_RS14785	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GS396_RS14785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GS396_RS14795	COG1113	amino acid transport
GS396_RS14800	COG2207	Transcriptional regulator
GS396_RS14800	COG1917	Cupin 2, conserved barrel domain protein
GS396_RS14805	COG0753	catalase activity
GS396_RS14830	COG1376	ErfK ybiS ycfS ynhG family protein
GS396_RS14835	COG0739	heme binding
GS396_RS14845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GS396_RS14855	COG0330	HflC and HflK could
GS396_RS14860	COG0330	HflC and HflK could
GS396_RS14865	COG0604	alcohol dehydrogenase
GS396_RS14880	COG0678	peroxiredoxin activity
GS396_RS14890	COG4953	penicillin-binding protein 1C
GS396_RS14895	COG2373	Large extracellular alpha-helical protein
GS396_RS14900	COG2079	MmgE PrpD family protein
GS396_RS14905	COG2828	Protein conserved in bacteria
GS396_RS14915	COG3609	addiction module antidote protein, CC2985 family
GS396_RS14935	COG3829	transcription factor binding
GS396_RS14940	COG0259	pyridoxamine-phosphate oxidase activity
GS396_RS14955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GS396_RS14975	COG0477	Major facilitator Superfamily
GS396_RS14980	COG5002	protein histidine kinase activity
GS396_RS14980	COG2198	Histidine kinase
GS396_RS14980	COG0784	Response regulator, receiver
GS396_RS14985	COG5002	protein histidine kinase activity
GS396_RS14985	COG0784	Response regulator, receiver
GS396_RS14995	COG3038	cytochrome b561
GS396_RS15010	COG1760	l-serine dehydratase
GS396_RS15015	COG2267	carboxylic ester hydrolase activity
GS396_RS15020	COG0527	aspartate kinase activity
GS396_RS15020	COG0460	homoserine dehydrogenase
GS396_RS15025	COG0626	cystathionine gamma-synthase activity
GS396_RS15030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GS396_RS15035	COG0739	heme binding
GS396_RS15040	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GS396_RS15045	COG1272	protein, Hemolysin III
GS396_RS15050	COG2982	Protein involved in outer membrane biogenesis
GS396_RS15060	COG0463	Glycosyl transferase, family 2
GS396_RS15065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GS396_RS15070	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GS396_RS15080	COG4771	TonB-dependent receptor
GS396_RS15085	COG2226	methyltransferase
GS396_RS15125	COG1960	acyl-CoA dehydrogenase activity
GS396_RS15155	COG0583	DNA-binding transcription factor activity
GS396_RS15170	COG0509	glycine decarboxylation via glycine cleavage system
GS396_RS15175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GS396_RS15185	COG0330	HflC and HflK could
GS396_RS15195	COG1742	UPF0060 membrane protein
GS396_RS15200	COG3956	TIGRFAM MazG family protein
GS396_RS15205	COG1218	3'(2'),5'-bisphosphate nucleotidase
GS396_RS15210	COG0494	nUDIX hydrolase
GS396_RS15220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GS396_RS15240	COG0840	transmembrane signaling receptor activity
GS396_RS15260	COG0189	ligase activity
GS396_RS15275	COG1199	ATP-dependent helicase activity
GS396_RS15285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GS396_RS15290	COG1216	Glycosyl transferase, family 2
GS396_RS15300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GS396_RS15310	COG1643	Atp-dependent helicase
GS396_RS15315	COG0783	Belongs to the Dps family
GS396_RS15320	COG0514	ATP-dependent DNA helicase (RecQ)
GS396_RS15435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GS396_RS15440	COG0602	queuosine metabolic process
GS396_RS15450	COG2885	chlorophyll binding
GS396_RS15455	COG0823	Involved in the tonB-independent uptake of proteins
GS396_RS15470	COG0811	peptide transport
GS396_RS15475	COG0824	Thioesterase
GS396_RS15480	COG2255	four-way junction helicase activity
GS396_RS15490	COG0632	four-way junction helicase activity
GS396_RS15495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GS396_RS15500	COG0217	transcriptional regulatory protein
GS396_RS15520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GS396_RS15550	COG0488	(ABC) transporter
GS396_RS15560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GS396_RS15560	COG4651	solute:proton antiporter activity
GS396_RS15570	COG0745	RESPONSE REGULATOR receiver
GS396_RS15575	COG2205	protein histidine kinase activity
GS396_RS15585	COG0542	response to heat
GS396_RS15605	COG0028	Belongs to the TPP enzyme family
GS396_RS15630	COG3387	PFAM Glycoside hydrolase 15-related
GS396_RS15635	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GS396_RS15640	COG3011	Protein conserved in bacteria
GS396_RS15655	COG0564	pseudouridine synthase activity
GS396_RS15660	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GS396_RS15670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GS396_RS15670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GS396_RS15680	COG0045	succinate-CoA ligase (ADP-forming) activity
GS396_RS15715	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GS396_RS15730	COG2205	protein histidine kinase activity
GS396_RS15735	COG0745	RESPONSE REGULATOR receiver
GS396_RS15745	COG0189	ligase activity
GS396_RS15765	COG3152	Membrane
GS396_RS15780	COG3240	lipase activity
GS396_RS15780	COG4625	pathogenesis
GS396_RS15790	COG2022	thiamine diphosphate biosynthetic process
GS396_RS15795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GS396_RS15800	COG3273	potassium ion transport
GS396_RS15800	COG0471	metal ion transport
GS396_RS15820	COG1970	mechanosensitive ion channel activity
GS396_RS15830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GS396_RS15835	COG1115	amino acid carrier protein
GS396_RS15845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GS396_RS15850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS15875	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GS396_RS15885	COG3588	fructose-bisphosphate aldolase
GS396_RS15890	COG0469	pyruvate kinase activity
GS396_RS15900	COG0126	phosphoglycerate kinase activity
GS396_RS15915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GS396_RS15920	COG3047	cAMP biosynthetic process
GS396_RS15960	COG3093	addiction module antidote protein HigA
GS396_RS15970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GS396_RS15975	COG1301	dicarboxylic acid transport
GS396_RS15985	COG2304	oxidoreductase activity
GS396_RS16005	COG0714	Associated with various cellular activities
GS396_RS16035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GS396_RS16050	COG5295	Hep Hag repeat protein
GS396_RS16090	COG0254	rRNA binding
GS396_RS16100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GS396_RS16110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GS396_RS16115	COG1758	RNA polymerase activity
GS396_RS16130	COG0437	4 iron, 4 sulfur cluster binding
GS396_RS16135	COG2864	formate dehydrogenase
GS396_RS16145	COG1921	L-seryl-tRNASec selenium transferase activity
GS396_RS16150	COG3276	selenocysteine insertion sequence binding
GS396_RS16160	COG0709	Synthesizes selenophosphate from selenide and ATP
GS396_RS16165	COG1561	YicC-like family, N-terminal region
GS396_RS16170	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GS396_RS16175	COG0346	lactoylglutathione lyase activity
GS396_RS16185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GS396_RS16200	COG0006	proline dipeptidase activity
GS396_RS16205	COG0006	proline dipeptidase activity
GS396_RS16210	COG3079	Belongs to the UPF0149 family
GS396_RS16230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GS396_RS16240	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GS396_RS16250	COG2912	Transglutaminase-like superfamily
GS396_RS16255	COG1773	rubredoxin
GS396_RS16265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GS396_RS16270	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GS396_RS16280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GS396_RS16285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GS396_RS16295	COG4221	oxidoreductase activity
GS396_RS16310	COG3209	COG3209 Rhs family protein
GS396_RS16330	COG0671	phosphoesterase, PA-phosphatase related
GS396_RS16340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GS396_RS16345	COG0563	adenylate kinase activity
GS396_RS16370	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GS396_RS16380	COG0848	biopolymer transport protein
GS396_RS16390	COG2832	Protein of unknown function (DUF454)
GS396_RS16425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GS396_RS16450	COG0823	Involved in the tonB-independent uptake of proteins
GS396_RS16460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GS396_RS16465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GS396_RS16470	COG0405	Gamma-glutamyltransferase
GS396_RS16475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GS396_RS16495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GS396_RS16500	COG2226	methyltransferase
GS396_RS16515	COG0473	3-isopropylmalate dehydrogenase activity
GS396_RS16530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GS396_RS16535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS16550	COG1538	Outer membrane efflux protein
GS396_RS16555	COG0531	amino acid
GS396_RS16560	COG1519	Transferase
GS396_RS16565	COG1560	Kdo2-lipid A biosynthetic process
GS396_RS16600	COG1301	dicarboxylic acid transport
GS396_RS16610	COG4191	Histidine kinase
GS396_RS16625	COG1840	ABC-type Fe3 transport system, periplasmic component
GS396_RS16630	COG0642	Histidine kinase
GS396_RS16645	COG2851	Citrate transporter
GS396_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS16670	COG1162	GTPase activity
GS396_RS16675	COG0436	Aminotransferase
GS396_RS16685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GS396_RS16695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GS396_RS16710	COG1228	amidohydrolase
GS396_RS16715	COG0804	urea catabolic process
GS396_RS16725	COG1307	EDD domain protein, DegV family
GS396_RS16765	COG2203	Gaf domain
GS396_RS16765	COG5001	Diguanylate cyclase
GS396_RS16765	COG3706	GGDEF domain
GS396_RS16765	COG4251	negative regulation of phosphorylation
GS396_RS16770	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GS396_RS16780	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GS396_RS16790	COG4206	TonB-dependent receptor
GS396_RS16800	COG1902	pentaerythritol trinitrate reductase activity
GS396_RS16825	COG0583	DNA-binding transcription factor activity
GS396_RS16830	COG1064	alcohol dehydrogenase
GS396_RS16850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GS396_RS16855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GS396_RS16870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GS396_RS16885	COG1522	sequence-specific DNA binding
GS396_RS16895	COG4773	Receptor
GS396_RS16920	COG0617	tRNA 3'-terminal CCA addition
GS396_RS16950	COG3468	outer membrane autotransporter barrel domain protein
GS396_RS16960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GS396_RS16965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GS396_RS16970	COG1609	Transcriptional regulator
GS396_RS16980	COG0837	glucose binding
GS396_RS16990	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GS396_RS17010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GS396_RS17020	COG4191	Histidine kinase
GS396_RS17025	COG0784	Response regulator, receiver
GS396_RS17030	COG4251	negative regulation of phosphorylation
GS396_RS17035	COG2823	Periplasmic or secreted lipoprotein
GS396_RS17040	COG0673	inositol 2-dehydrogenase activity
GS396_RS17045	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GS396_RS17065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GS396_RS17070	COG0321	lipoyl(octanoyl) transferase activity
GS396_RS17075	COG2921	Belongs to the UPF0250 family
GS396_RS17085	COG1686	Belongs to the peptidase S11 family
GS396_RS17090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GS396_RS17095	COG2951	lytic endotransglycosylase activity
GS396_RS17105	COG0772	Belongs to the SEDS family
GS396_RS17110	COG0772	Belongs to the SEDS family
GS396_RS17115	COG0768	penicillin binding
GS396_RS17125	COG1792	Involved in formation and maintenance of cell shape
GS396_RS17130	COG1077	Cell shape determining protein MreB Mrl
GS396_RS17150	COG0308	aminopeptidase N
GS396_RS17155	COG2226	methyltransferase
GS396_RS17180	COG1943	Transposase
GS396_RS17185	COG1538	Outer membrane efflux protein
GS396_RS17190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GS396_RS17195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS17215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GS396_RS17235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GS396_RS17245	COG2832	Protein of unknown function (DUF454)
GS396_RS17260	COG1505	serine-type exopeptidase activity
GS396_RS17285	COG0697	spore germination
GS396_RS17290	COG1666	GTP binding
GS396_RS17320	COG0339	signal peptide processing
GS396_RS17330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GS396_RS17350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GS396_RS17360	COG1136	(ABC) transporter
GS396_RS17365	COG1136	(ABC) transporter
GS396_RS17365	COG0577	efflux transmembrane transporter activity
GS396_RS17370	COG0577	efflux transmembrane transporter activity
GS396_RS17380	COG2204	response regulator
GS396_RS17385	COG4191	Histidine kinase
GS396_RS17395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GS396_RS17410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GS396_RS17415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GS396_RS17420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GS396_RS17425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GS396_RS17430	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GS396_RS17435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GS396_RS17445	COG0356	it plays a direct role in the translocation of protons across the membrane
GS396_RS17460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GS396_RS17465	COG0508	dehydrogenase complex catalyzes the overall conversion of
GS396_RS17485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GS396_RS17510	COG0181	hydroxymethylbilane synthase activity
GS396_RS17520	COG2972	Histidine kinase
GS396_RS17520	COG0745	RESPONSE REGULATOR receiver
GS396_RS17535	COG4771	TonB-dependent receptor
GS396_RS17545	COG0840	transmembrane signaling receptor activity
GS396_RS17600	COG0583	DNA-binding transcription factor activity
GS396_RS17605	COG0477	Major facilitator Superfamily
GS396_RS17640	COG0625	glutathione transferase activity
GS396_RS17645	COG2259	Doxx family
GS396_RS17690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GS396_RS17695	COG1490	D-aminoacyl-tRNA deacylase activity
GS396_RS17740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GS396_RS17740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GS396_RS17745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GS396_RS17750	COG0242	peptide deformylase activity
GS396_RS17760	COG0758	DNA mediated transformation
GS396_RS17765	COG2922	Belongs to the Smg family
GS396_RS17775	COG1714	RDD family
GS396_RS17780	COG1754	DNA topoisomerase type I activity
GS396_RS17780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GS396_RS17785	COG0009	L-threonylcarbamoyladenylate synthase
GS396_RS17800	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS17810	COG0616	signal peptide processing
GS396_RS17815	COG0534	Mate efflux family protein
GS396_RS17830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GS396_RS17835	COG0625	glutathione transferase activity
GS396_RS17845	COG1252	NADH dehydrogenase
GS396_RS17865	COG2860	membrane
GS396_RS17870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GS396_RS17890	COG1846	Transcriptional regulator
GS396_RS17895	COG2205	protein histidine kinase activity
GS396_RS17900	COG0745	RESPONSE REGULATOR receiver
GS396_RS17920	COG0459	protein refolding
GS396_RS17925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GS396_RS17930	COG2356	endonuclease I
GS396_RS17935	COG1324	tolerance protein
GS396_RS17945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GS396_RS17955	COG0840	transmembrane signaling receptor activity
GS396_RS17975	COG4585	Histidine kinase
GS396_RS17995	COG0583	DNA-binding transcription factor activity
GS396_RS18005	COG1785	Belongs to the alkaline phosphatase family
GS396_RS18010	COG1686	Belongs to the peptidase S11 family
GS396_RS18020	COG2249	NAD(P)H dehydrogenase (quinone) activity
GS396_RS18030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GS396_RS18040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GS396_RS18050	COG0511	ligase activity, forming carbon-carbon bonds
GS396_RS18055	COG0439	Biotin carboxylase
GS396_RS18070	COG2264	protein methyltransferase activity
GS396_RS18080	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GS396_RS18085	COG4589	Belongs to the CDS family
GS396_RS18090	COG0204	Acyl-transferase
GS396_RS18100	COG0671	phosphoesterase, PA-phosphatase related
GS396_RS18100	COG2453	phosphatase
GS396_RS18105	COG2267	carboxylic ester hydrolase activity
GS396_RS18110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GS396_RS18115	COG0138	bifunctional purine biosynthesis protein purh
GS396_RS18125	COG0151	Belongs to the GarS family
GS396_RS18140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GS396_RS18145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GS396_RS18150	COG2201	protein-glutamate methylesterase activity
GS396_RS18155	COG2177	Part of the ABC transporter FtsEX involved in
GS396_RS18160	COG2884	Cell division ATP-binding protein ftsE
GS396_RS18170	COG3118	belongs to the thioredoxin family
GS396_RS18175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GS396_RS18180	COG3706	GGDEF domain
GS396_RS18190	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GS396_RS18225	COG1652	LysM domain
GS396_RS18230	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GS396_RS18230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GS396_RS18235	COG1473	amidohydrolase
GS396_RS18240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS18245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GS396_RS18260	COG1289	transmembrane transporter activity
GS396_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS18270	COG2814	Major facilitator Superfamily
GS396_RS18300	COG0316	Belongs to the HesB IscA family
GS396_RS18325	COG0784	Response regulator, receiver
GS396_RS18325	COG5002	protein histidine kinase activity
GS396_RS18325	COG2205	protein histidine kinase activity
GS396_RS18345	COG1051	belongs to the nudix hydrolase family
GS396_RS18360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GS396_RS18365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GS396_RS18375	COG2076	Multidrug Resistance protein
GS396_RS18380	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GS396_RS18385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GS396_RS18390	COG0730	response to heat
GS396_RS18400	COG0134	indole-3-glycerol-phosphate synthase activity
GS396_RS18405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GS396_RS18435	COG1597	lipid kinase activity
GS396_RS18450	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GS396_RS18455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GS396_RS18465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GS396_RS18465	COG2111	Na H antiporter
GS396_RS18470	COG1006	Multisubunit Na H antiporter MnhC subunit
GS396_RS18475	COG0651	ATP synthesis coupled electron transport
GS396_RS18480	COG1863	multisubunit Na H antiporter MnhE subunit
GS396_RS18485	COG2212	antiporter activity
GS396_RS18490	COG1320	monovalent cation:proton antiporter activity
GS396_RS18495	COG0530	calcium, potassium:sodium antiporter activity
GS396_RS18535	COG3104	oligopeptide transport
GS396_RS18540	COG3483	tryptophan 2,3-dioxygenase activity
GS396_RS18575	COG2378	regulation of single-species biofilm formation
GS396_RS18590	COG2354	Protein conserved in bacteria
GS396_RS18595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GS396_RS18600	COG1368	sulfuric ester hydrolase activity
GS396_RS18605	COG3264	Mechanosensitive ion channel
GS396_RS18605	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GS396_RS18620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GS396_RS18640	COG0745	RESPONSE REGULATOR receiver
GS396_RS18655	COG1166	arginine decarboxylase activity
GS396_RS18660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GS396_RS18680	COG2960	long-chain fatty acid transporting porin activity
GS396_RS18715	COG0606	chelatase, subunit chli
GS396_RS18735	COG0561	phosphatase activity
GS396_RS18740	COG3932	Exopolysaccharide synthesis, ExoD
GS396_RS18765	COG1999	signal sequence binding
GS396_RS18770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GS396_RS18775	COG1845	cytochrome c oxidase, subunit III
GS396_RS18785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GS396_RS18790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GS396_RS18805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GS396_RS18835	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GS396_RS18855	COG2031	fatty acid transporter
GS396_RS18865	COG0489	protein tyrosine kinase activity
GS396_RS18865	COG3206	protein involved in exopolysaccharide biosynthesis
GS396_RS18915	COG0673	inositol 2-dehydrogenase activity
GS396_RS18925	COG1501	Belongs to the glycosyl hydrolase 31 family
GS396_RS18930	COG2222	sugar isomerase
GS396_RS18935	COG1940	carbohydrate kinase activity
GS396_RS18945	COG1349	DNA-binding transcription factor activity
GS396_RS18950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GS396_RS18955	COG2814	Major facilitator Superfamily
GS396_RS18970	COG1040	competence protein
GS396_RS18985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GS396_RS18990	COG0156	8-amino-7-oxononanoate synthase activity
GS396_RS18995	COG2267	carboxylic ester hydrolase activity
GS396_RS19000	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS19035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GS396_RS19040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GS396_RS19045	COG2205	protein histidine kinase activity
GS396_RS19050	COG0745	RESPONSE REGULATOR receiver
GS396_RS19055	COG3541	Predicted nucleotidyltransferase
GS396_RS19060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GS396_RS19085	COG0714	Associated with various cellular activities
GS396_RS19100	COG0754	glutathionylspermidine amidase activity
GS396_RS19110	COG0129	dihydroxy-acid dehydratase activity
GS396_RS19120	COG1199	ATP-dependent helicase activity
GS396_RS19130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GS396_RS19150	COG3781	membrane
GS396_RS19170	COG3291	Pkd domain containing protein
GS396_RS19190	COG0625	glutathione transferase activity
GS396_RS19210	COG2207	Transcriptional regulator
GS396_RS19225	COG4555	ABC transporter
GS396_RS19235	COG3706	GGDEF domain
GS396_RS19255	COG0633	Ferredoxin
GS396_RS19255	COG0543	2 iron, 2 sulfur cluster binding
GS396_RS19260	COG1131	(ABC) transporter
GS396_RS19265	COG0842	Transport permease protein
GS396_RS19280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GS396_RS19290	COG0084	hydrolase, TatD family'
GS396_RS19295	COG1643	Atp-dependent helicase
GS396_RS19305	COG1187	pseudouridine synthase activity
GS396_RS19320	COG0667	Aldo Keto reductase
GS396_RS19335	COG1690	Belongs to the RtcB family
GS396_RS19345	COG1959	2 iron, 2 sulfur cluster binding
GS396_RS19355	COG0583	DNA-binding transcription factor activity
GS396_RS19360	COG2814	Major facilitator Superfamily
GS396_RS19365	COG0656	L-ascorbic acid biosynthetic process
GS396_RS19370	COG2205	protein histidine kinase activity
GS396_RS19370	COG2198	Histidine kinase
GS396_RS19370	COG0784	Response regulator, receiver
GS396_RS19385	COG2267	carboxylic ester hydrolase activity
GS396_RS19395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GS396_RS19395	COG1042	CoA-binding domain protein
GS396_RS19395	COG0045	succinate-CoA ligase (ADP-forming) activity
GS396_RS19400	COG2239	Acts as a magnesium transporter
GS396_RS19415	COG3100	YcgL domain-containing protein
GS396_RS19430	COG1028	Short-chain dehydrogenase reductase Sdr
GS396_RS19450	COG0644	oxidoreductase
GS396_RS19470	COG2986	histidine ammonia-lyase
GS396_RS19480	COG0463	Glycosyl transferase, family 2
GS396_RS19495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GS396_RS19500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GS396_RS19515	COG1294	oxidase, subunit
GS396_RS19520	COG1271	oxidase subunit
GS396_RS19540	COG1595	DNA-templated transcription, initiation
GS396_RS19555	COG0494	nUDIX hydrolase
GS396_RS19575	COG0408	coproporphyrinogen oxidase activity
GS396_RS19585	COG2323	membrane
GS396_RS19600	COG0589	response to stress
GS396_RS19615	COG0210	DNA helicase
GS396_RS19625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GS396_RS19630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GS396_RS19635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GS396_RS19645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GS396_RS19655	COG0251	oxidation-reduction process
GS396_RS19690	COG0463	Glycosyl transferase, family 2
GS396_RS19705	COG1475	DNA binding
GS396_RS19710	COG1192	Involved in chromosome partitioning
GS396_RS19715	COG0357	Ribosomal RNA small subunit methyltransferase G
GS396_RS19720	COG2091	lysine biosynthetic process via aminoadipic acid
GS396_RS19760	COG1943	Transposase
GS396_RS19765	COG1971	Probably functions as a manganese efflux pump
GS396_RS19770	COG2205	protein histidine kinase activity
GS396_RS19770	COG0784	Response regulator, receiver
GS396_RS19780	COG2911	Protein conserved in bacteria
GS396_RS19785	COG0729	surface antigen
GS396_RS19795	COG0752	glycyl-tRNA synthetase alpha subunit
GS396_RS19805	COG0519	Catalyzes the synthesis of GMP from XMP
GS396_RS19805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GS396_RS19815	COG0805	protein transport
GS396_RS19825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GS396_RS19835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GS396_RS19845	COG0840	transmembrane signaling receptor activity
GS396_RS19900	COG3135	benzoate transporter
GS396_RS19915	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GS396_RS19920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GS396_RS19925	COG3706	GGDEF domain
GS396_RS19930	COG3012	SEC-C Motif Domain Protein
GS396_RS19955	COG0302	gtp cyclohydrolase
GS396_RS19970	COG1566	PFAM secretion protein HlyD family protein
GS396_RS19975	COG1538	Outer membrane efflux protein
GS396_RS19980	COG1289	transmembrane transporter activity
GS396_RS19995	COG1074	ATP-dependent DNA helicase activity
GS396_RS20000	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GS396_RS20005	COG1127	ABC transporter
GS396_RS20010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GS396_RS20015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GS396_RS20030	COG2853	Lipoprotein
GS396_RS20035	COG0386	Belongs to the glutathione peroxidase family
GS396_RS20045	COG1322	Protein conserved in bacteria
GS396_RS20060	COG0583	DNA-binding transcription factor activity
GS396_RS20080	COG0667	Aldo Keto reductase
GS396_RS20085	COG0531	amino acid
GS396_RS20095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GS396_RS20100	COG0861	Integral membrane protein TerC family
GS396_RS20110	COG0584	glycerophosphoryl diester phosphodiesterase
GS396_RS20130	COG0706	membrane insertase activity
GS396_RS20135	COG0594	ribonuclease P activity
GS396_RS20140	COG0230	Belongs to the bacterial ribosomal protein bL34 family