locus-tag	class	description
SmaCSM2_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SmaCSM2_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SmaCSM2_RS00020	COG0187	DNA topoisomerase II activity
SmaCSM2_RS00025	COG1266	CAAX protease self-immunity
SmaCSM2_RS00030	COG0501	Belongs to the peptidase M48B family
SmaCSM2_RS00060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SmaCSM2_RS00130	COG2814	Major facilitator Superfamily
SmaCSM2_RS00190	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SmaCSM2_RS00200	COG4772	TonB-dependent receptor
SmaCSM2_RS00235	COG0800	Aldolase
SmaCSM2_RS00250	COG3186	Phenylalanine-4-hydroxylase
SmaCSM2_RS00255	COG1522	sequence-specific DNA binding
SmaCSM2_RS00260	COG1752	Esterase of the alpha-beta hydrolase superfamily
SmaCSM2_RS00290	COG1122	ATPase activity
SmaCSM2_RS00310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SmaCSM2_RS00315	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SmaCSM2_RS00335	COG0210	DNA helicase
SmaCSM2_RS00345	COG3132	Protein of unknown function, DUF480
SmaCSM2_RS00350	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SmaCSM2_RS00355	COG0284	orotidine-5'-phosphate decarboxylase activity
SmaCSM2_RS00360	COG5640	endopeptidase activity
SmaCSM2_RS00370	COG2937	Belongs to the GPAT DAPAT family
SmaCSM2_RS00380	COG0037	tRNA processing
SmaCSM2_RS00385	COG2974	May be involved in recombination
SmaCSM2_RS00395	COG1803	Methylglyoxal synthase
SmaCSM2_RS00400	COG2205	protein histidine kinase activity
SmaCSM2_RS00400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SmaCSM2_RS00405	COG0493	'glutamate synthase
SmaCSM2_RS00410	COG0067	glutamate synthase
SmaCSM2_RS00410	COG0070	glutamate synthase
SmaCSM2_RS00410	COG0069	glutamate synthase activity
SmaCSM2_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS00470	COG1111	helicase
SmaCSM2_RS00470	COG1205	dead DEAH box helicase
SmaCSM2_RS00510	COG0714	Associated with various cellular activities
SmaCSM2_RS00530	COG0312	modulator of DNA gyrase
SmaCSM2_RS00555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SmaCSM2_RS00575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SmaCSM2_RS00600	COG1881	PFAM PEBP family protein
SmaCSM2_RS00615	COG1968	undecaprenyl-diphosphatase activity
SmaCSM2_RS00620	COG0174	glutamine synthetase
SmaCSM2_RS00625	COG0347	Belongs to the P(II) protein family
SmaCSM2_RS00630	COG0004	ammonium transporteR
SmaCSM2_RS00635	COG2831	hemolysin activation secretion protein
SmaCSM2_RS00640	COG3210	domain, Protein
SmaCSM2_RS00640	COG3210	domain, Protein
SmaCSM2_RS00650	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SmaCSM2_RS00660	COG3852	Histidine kinase
SmaCSM2_RS00665	COG2204	response regulator
SmaCSM2_RS00670	COG2032	superoxide dismutase activity
SmaCSM2_RS00675	COG2032	superoxide dismutase activity
SmaCSM2_RS00685	COG0183	Belongs to the thiolase family
SmaCSM2_RS00720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SmaCSM2_RS00725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SmaCSM2_RS00780	COG2837	iron assimilation
SmaCSM2_RS00820	COG2197	response regulator
SmaCSM2_RS00825	COG2205	protein histidine kinase activity
SmaCSM2_RS00825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SmaCSM2_RS00830	COG3474	cytochrome
SmaCSM2_RS00840	COG1960	acyl-CoA dehydrogenase activity
SmaCSM2_RS00850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SmaCSM2_RS00860	COG0612	Peptidase, M16
SmaCSM2_RS00870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SmaCSM2_RS00875	COG0596	Alpha beta hydrolase
SmaCSM2_RS00885	COG0318	PFAM AMP-dependent synthetase and ligase
SmaCSM2_RS00890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SmaCSM2_RS00900	COG1181	Belongs to the D-alanine--D-alanine ligase family
SmaCSM2_RS00910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SmaCSM2_RS00925	COG1215	transferase activity, transferring glycosyl groups
SmaCSM2_RS00930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SmaCSM2_RS00960	COG0339	signal peptide processing
SmaCSM2_RS00980	COG0681	Belongs to the peptidase S26 family
SmaCSM2_RS00985	COG2814	Major facilitator Superfamily
SmaCSM2_RS00990	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS00995	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS01000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SmaCSM2_RS01005	COG2224	Isocitrate lyase
SmaCSM2_RS01015	COG3706	GGDEF domain
SmaCSM2_RS01040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SmaCSM2_RS01045	COG1960	acyl-CoA dehydrogenase activity
SmaCSM2_RS01065	COG0697	spore germination
SmaCSM2_RS01075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SmaCSM2_RS01085	COG3188	usher protein
SmaCSM2_RS01105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SmaCSM2_RS01110	COG1280	lysine exporter protein (LysE YggA)
SmaCSM2_RS01115	COG1607	acyl-coa hydrolase
SmaCSM2_RS01125	COG1902	pentaerythritol trinitrate reductase activity
SmaCSM2_RS01145	COG1335	isochorismatase
SmaCSM2_RS01150	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SmaCSM2_RS01160	COG1056	cytidyltransferase-related domain
SmaCSM2_RS01160	COG1051	belongs to the nudix hydrolase family
SmaCSM2_RS01165	COG1752	Esterase of the alpha-beta hydrolase superfamily
SmaCSM2_RS01175	COG1396	sequence-specific DNA binding
SmaCSM2_RS01175	COG3800	Transcriptional regulator
SmaCSM2_RS01185	COG1960	acyl-CoA dehydrogenase activity
SmaCSM2_RS01190	COG1024	Enoyl-CoA hydratase
SmaCSM2_RS01195	COG1024	Enoyl-CoA hydratase
SmaCSM2_RS01205	COG1764	response to oxidative stress
SmaCSM2_RS01290	COG0659	secondary active sulfate transmembrane transporter activity
SmaCSM2_RS01305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SmaCSM2_RS01330	COG3228	Belongs to the MtfA family
SmaCSM2_RS01340	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SmaCSM2_RS01340	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SmaCSM2_RS01345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SmaCSM2_RS01390	COG3237	CsbD-like
SmaCSM2_RS01400	COG0180	Tryptophanyl-tRNA synthetase
SmaCSM2_RS01425	COG0477	Major facilitator Superfamily
SmaCSM2_RS01430	COG0697	spore germination
SmaCSM2_RS01445	COG1136	(ABC) transporter
SmaCSM2_RS01445	COG0577	efflux transmembrane transporter activity
SmaCSM2_RS01455	COG1136	(ABC) transporter
SmaCSM2_RS01475	COG4585	Histidine kinase
SmaCSM2_RS01480	COG2197	response regulator
SmaCSM2_RS01500	COG0546	phosphoglycolate phosphatase activity
SmaCSM2_RS01505	COG0628	permease
SmaCSM2_RS01525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SmaCSM2_RS01540	COG5507	3-demethylubiquinone-9 3-methyltransferase
SmaCSM2_RS01570	COG2814	Major facilitator Superfamily
SmaCSM2_RS01575	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS01580	COG4807	Protein conserved in bacteria
SmaCSM2_RS01585	COG4221	oxidoreductase activity
SmaCSM2_RS01595	COG0018	arginyl-trna synthetase
SmaCSM2_RS01600	COG2003	Belongs to the UPF0758 family
SmaCSM2_RS01605	COG2197	response regulator
SmaCSM2_RS01610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SmaCSM2_RS01635	COG2205	protein histidine kinase activity
SmaCSM2_RS01645	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SmaCSM2_RS01650	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SmaCSM2_RS01665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SmaCSM2_RS01670	COG0708	Exodeoxyribonuclease III
SmaCSM2_RS01675	COG2211	Major facilitator Superfamily
SmaCSM2_RS01685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SmaCSM2_RS01690	COG0739	heme binding
SmaCSM2_RS01695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SmaCSM2_RS01730	COG2234	aminopeptidase activity
SmaCSM2_RS01740	COG4942	peptidase
SmaCSM2_RS01745	COG0793	Belongs to the peptidase S41A family
SmaCSM2_RS01755	COG2067	long-chain fatty acid transport protein
SmaCSM2_RS01780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SmaCSM2_RS01785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SmaCSM2_RS01825	COG0109	protoheme IX farnesyltransferase activity
SmaCSM2_RS01845	COG0358	DNA primase activity
SmaCSM2_RS01850	COG1295	ribonuclease BN
SmaCSM2_RS01865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SmaCSM2_RS01875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SmaCSM2_RS01880	COG0668	transmembrane transport
SmaCSM2_RS01895	COG2133	pyrroloquinoline quinone binding
SmaCSM2_RS01900	COG4682	membrane
SmaCSM2_RS01910	COG0531	amino acid
SmaCSM2_RS01920	COG1737	Transcriptional regulator
SmaCSM2_RS01925	COG4948	Mandelate Racemase Muconate Lactonizing
SmaCSM2_RS01945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmaCSM2_RS01980	COG5383	Protein conserved in bacteria
SmaCSM2_RS01990	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SmaCSM2_RS01995	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SmaCSM2_RS02025	COG0778	Nitroreductase
SmaCSM2_RS02030	COG2353	YceI-like domain
SmaCSM2_RS02045	COG2375	cellular response to nickel ion
SmaCSM2_RS02135	COG2267	carboxylic ester hydrolase activity
SmaCSM2_RS02150	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SmaCSM2_RS02200	COG0488	(ABC) transporter
SmaCSM2_RS02205	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS02215	COG2814	Major facilitator Superfamily
SmaCSM2_RS02220	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SmaCSM2_RS02225	COG1113	amino acid transport
SmaCSM2_RS02235	COG0741	lytic transglycosylase activity
SmaCSM2_RS02260	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SmaCSM2_RS02270	COG5507	3-demethylubiquinone-9 3-methyltransferase
SmaCSM2_RS02275	COG4941	Belongs to the sigma-70 factor family
SmaCSM2_RS02305	COG3275	phosphorelay sensor kinase activity
SmaCSM2_RS02310	COG3279	Response regulator of the LytR AlgR family
SmaCSM2_RS02330	COG1309	transcriptional regulator
SmaCSM2_RS02340	COG2814	Major facilitator Superfamily
SmaCSM2_RS02345	COG3590	peptidase
SmaCSM2_RS02350	COG5001	Diguanylate cyclase
SmaCSM2_RS02355	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS02365	COG3384	dioxygenase
SmaCSM2_RS02370	COG0025	NhaP-type Na H and K H
SmaCSM2_RS02425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmaCSM2_RS02440	COG5002	protein histidine kinase activity
SmaCSM2_RS02455	COG2813	Specifically methylates the guanine in position
SmaCSM2_RS02460	COG1187	pseudouridine synthase activity
SmaCSM2_RS02465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SmaCSM2_RS02475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SmaCSM2_RS02480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SmaCSM2_RS02500	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS02505	COG2226	methyltransferase
SmaCSM2_RS02530	COG1956	GAF domain-containing protein
SmaCSM2_RS02535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SmaCSM2_RS02540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SmaCSM2_RS02545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SmaCSM2_RS02550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SmaCSM2_RS02550	COG0785	Cytochrome C biogenesis protein
SmaCSM2_RS02555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SmaCSM2_RS02560	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS02565	COG5002	protein histidine kinase activity
SmaCSM2_RS02570	COG2205	protein histidine kinase activity
SmaCSM2_RS02575	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS02580	COG0367	asparagine synthase
SmaCSM2_RS02590	COG0720	synthase
SmaCSM2_RS02615	COG0513	Belongs to the DEAD box helicase family
SmaCSM2_RS02625	COG0625	glutathione transferase activity
SmaCSM2_RS02665	COG0626	cystathionine gamma-synthase activity
SmaCSM2_RS02695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SmaCSM2_RS02695	COG2755	lipolytic protein G-D-S-L family
SmaCSM2_RS02725	COG1233	COG1233 Phytoene dehydrogenase and related
SmaCSM2_RS02740	COG0300	oxidoreductase activity
SmaCSM2_RS02745	COG0277	FAD linked oxidase domain protein
SmaCSM2_RS02750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SmaCSM2_RS02750	COG0546	phosphoglycolate phosphatase activity
SmaCSM2_RS02800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SmaCSM2_RS02820	COG1216	Glycosyl transferase, family 2
SmaCSM2_RS02835	COG1127	ABC transporter
SmaCSM2_RS02840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SmaCSM2_RS02855	COG0442	prolyl-tRNA aminoacylation
SmaCSM2_RS02865	COG1183	phosphatidylcholine synthase activity
SmaCSM2_RS02885	COG0525	valine-tRNA ligase activity
SmaCSM2_RS02900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SmaCSM2_RS02910	COG0795	lipopolysaccharide-transporting ATPase activity
SmaCSM2_RS02920	COG4974	Belongs to the 'phage' integrase family
SmaCSM2_RS02925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SmaCSM2_RS02945	COG0047	phosphoribosylformylglycinamidine synthase activity
SmaCSM2_RS02945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SmaCSM2_RS02955	COG1404	Belongs to the peptidase S8 family
SmaCSM2_RS02960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SmaCSM2_RS02965	COG1459	type II secretion system
SmaCSM2_RS02970	COG2165	general secretion pathway protein
SmaCSM2_RS02975	COG4970	Tfp pilus assembly protein FimT
SmaCSM2_RS02980	COG2165	general secretion pathway protein
SmaCSM2_RS02985	COG4795	General secretion pathway protein
SmaCSM2_RS02990	COG3156	type II secretion system protein K
SmaCSM2_RS02995	COG3166	PFAM Fimbrial assembly family protein
SmaCSM2_RS03010	COG1450	Type ii and iii secretion system protein
SmaCSM2_RS03035	COG3539	Fimbrial protein
SmaCSM2_RS03040	COG3121	Chaperone
SmaCSM2_RS03055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SmaCSM2_RS03065	COG1215	transferase activity, transferring glycosyl groups
SmaCSM2_RS03080	COG2252	PERMEase
SmaCSM2_RS03085	COG0488	(ABC) transporter
SmaCSM2_RS03095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SmaCSM2_RS03110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SmaCSM2_RS03115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SmaCSM2_RS03115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SmaCSM2_RS03150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SmaCSM2_RS03155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SmaCSM2_RS03165	COG3152	Membrane
SmaCSM2_RS03180	COG0277	FAD linked oxidase domain protein
SmaCSM2_RS03185	COG1988	membrane-bound metal-dependent
SmaCSM2_RS03220	COG2001	Belongs to the MraZ family
SmaCSM2_RS03225	COG0275	rRNA processing
SmaCSM2_RS03230	COG3116	cell division
SmaCSM2_RS03240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SmaCSM2_RS03245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SmaCSM2_RS03265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SmaCSM2_RS03270	COG1181	Belongs to the D-alanine--D-alanine ligase family
SmaCSM2_RS03275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SmaCSM2_RS03285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SmaCSM2_RS03290	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SmaCSM2_RS03300	COG0739	heme binding
SmaCSM2_RS03305	COG0653	protein targeting
SmaCSM2_RS03310	COG0494	nUDIX hydrolase
SmaCSM2_RS03320	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SmaCSM2_RS03325	COG2267	carboxylic ester hydrolase activity
SmaCSM2_RS03330	COG3275	phosphorelay sensor kinase activity
SmaCSM2_RS03335	COG3279	Response regulator of the LytR AlgR family
SmaCSM2_RS03340	COG0402	S-adenosylhomocysteine deaminase activity
SmaCSM2_RS03360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SmaCSM2_RS03365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SmaCSM2_RS03375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SmaCSM2_RS03380	COG1607	acyl-coa hydrolase
SmaCSM2_RS03385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SmaCSM2_RS03405	COG4106	trans-aconitate 2-methyltransferase activity
SmaCSM2_RS03410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SmaCSM2_RS03425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SmaCSM2_RS03430	COG0667	Aldo Keto reductase
SmaCSM2_RS03440	COG4771	TonB-dependent receptor
SmaCSM2_RS03465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SmaCSM2_RS03470	COG4181	ATPase activity
SmaCSM2_RS03485	COG0642	Histidine kinase
SmaCSM2_RS03495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SmaCSM2_RS03500	COG0861	Integral membrane protein TerC family
SmaCSM2_RS03505	COG2814	Major facilitator Superfamily
SmaCSM2_RS03510	COG1704	LemA family
SmaCSM2_RS03525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SmaCSM2_RS03530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SmaCSM2_RS03540	COG3738	Protein conserved in bacteria
SmaCSM2_RS03545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SmaCSM2_RS03550	COG2967	ApaG domain
SmaCSM2_RS03555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SmaCSM2_RS03560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SmaCSM2_RS03565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SmaCSM2_RS03570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SmaCSM2_RS03580	COG2096	Adenosyltransferase
SmaCSM2_RS03590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SmaCSM2_RS03595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SmaCSM2_RS03605	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
SmaCSM2_RS03625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SmaCSM2_RS03635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SmaCSM2_RS03645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SmaCSM2_RS03650	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS03655	COG3634	alkyl hydroperoxide reductase activity
SmaCSM2_RS03665	COG2890	protein-(glutamine-N5) methyltransferase activity
SmaCSM2_RS03715	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SmaCSM2_RS03740	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SmaCSM2_RS03755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SmaCSM2_RS03760	COG1404	Belongs to the peptidase S8 family
SmaCSM2_RS03780	COG1295	ribonuclease BN
SmaCSM2_RS03785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SmaCSM2_RS03805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SmaCSM2_RS03810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SmaCSM2_RS03825	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SmaCSM2_RS03835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SmaCSM2_RS03840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SmaCSM2_RS03845	COG0193	aminoacyl-tRNA hydrolase activity
SmaCSM2_RS03850	COG0012	GTP binding
SmaCSM2_RS03860	COG2197	response regulator
SmaCSM2_RS03865	COG0784	Response regulator, receiver
SmaCSM2_RS03865	COG2205	protein histidine kinase activity
SmaCSM2_RS03870	COG2199	diguanylate cyclase activity
SmaCSM2_RS03870	COG2200	EAL domain
SmaCSM2_RS03870	COG2203	Gaf domain
SmaCSM2_RS03875	COG0784	Response regulator, receiver
SmaCSM2_RS03875	COG2205	protein histidine kinase activity
SmaCSM2_RS03880	COG4206	TonB-dependent receptor
SmaCSM2_RS03885	COG4242	Belongs to the peptidase S51 family
SmaCSM2_RS03910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SmaCSM2_RS03925	COG0250	Participates in transcription elongation, termination and antitermination
SmaCSM2_RS03930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SmaCSM2_RS03935	COG0081	regulation of translation
SmaCSM2_RS03945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SmaCSM2_RS03950	COG0222	ribosome binding
SmaCSM2_RS03955	COG0085	RNA polymerase activity
SmaCSM2_RS03960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SmaCSM2_RS03965	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SmaCSM2_RS03970	COG0049	tRNA binding
SmaCSM2_RS03975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SmaCSM2_RS03980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SmaCSM2_RS03985	COG0051	transcription antitermination factor activity, RNA binding
SmaCSM2_RS03990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SmaCSM2_RS03995	COG0088	Forms part of the polypeptide exit tunnel
SmaCSM2_RS04000	COG0089	rRNA binding
SmaCSM2_RS04005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SmaCSM2_RS04010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SmaCSM2_RS04015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SmaCSM2_RS04020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SmaCSM2_RS04025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SmaCSM2_RS04030	COG0255	Belongs to the universal ribosomal protein uL29 family
SmaCSM2_RS04035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SmaCSM2_RS04040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SmaCSM2_RS04045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SmaCSM2_RS04050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SmaCSM2_RS04055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SmaCSM2_RS04060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SmaCSM2_RS04065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SmaCSM2_RS04070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SmaCSM2_RS04075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SmaCSM2_RS04080	COG1841	ribosomal large subunit assembly
SmaCSM2_RS04085	COG0200	Binds to the 23S rRNA
SmaCSM2_RS04090	COG0201	protein transport
SmaCSM2_RS04095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SmaCSM2_RS04100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SmaCSM2_RS04105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SmaCSM2_RS04110	COG0202	RNA polymerase activity
SmaCSM2_RS04115	COG0203	ribosomal protein L17
SmaCSM2_RS04130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SmaCSM2_RS04145	COG0154	amidase activity
SmaCSM2_RS04160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SmaCSM2_RS04165	COG0039	L-malate dehydrogenase activity
SmaCSM2_RS04175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SmaCSM2_RS04190	COG0625	glutathione transferase activity
SmaCSM2_RS04200	COG1902	pentaerythritol trinitrate reductase activity
SmaCSM2_RS04200	COG0446	pyridine nucleotide-disulphide oxidoreductase
SmaCSM2_RS04205	COG2364	Membrane
SmaCSM2_RS04210	COG0604	alcohol dehydrogenase
SmaCSM2_RS04225	COG1187	pseudouridine synthase activity
SmaCSM2_RS04245	COG1063	alcohol dehydrogenase
SmaCSM2_RS04255	COG0588	phosphoglycerate mutase activity
SmaCSM2_RS04260	COG0285	dihydrofolate synthase activity
SmaCSM2_RS04280	COG2833	Protein of unknown function (DUF455)
SmaCSM2_RS04290	COG3291	Pkd domain containing protein
SmaCSM2_RS04295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SmaCSM2_RS04300	COG0671	phosphoesterase, PA-phosphatase related
SmaCSM2_RS04310	COG4206	TonB-dependent receptor
SmaCSM2_RS04315	COG0248	Ppx GppA phosphatase
SmaCSM2_RS04320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SmaCSM2_RS04335	COG4783	chaperone-mediated protein folding
SmaCSM2_RS04350	COG0473	3-isopropylmalate dehydrogenase activity
SmaCSM2_RS04370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SmaCSM2_RS04415	COG0544	peptidyl-prolyl cis-trans isomerase activity
SmaCSM2_RS04420	COG0740	serine-type endopeptidase activity
SmaCSM2_RS04425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SmaCSM2_RS04465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SmaCSM2_RS04470	COG3942	CHAP domain
SmaCSM2_RS04470	COG1388	LysM domain
SmaCSM2_RS04475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SmaCSM2_RS04480	COG2226	methyltransferase
SmaCSM2_RS04485	COG0328	RNA-DNA hybrid ribonuclease activity
SmaCSM2_RS04490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SmaCSM2_RS04495	COG0631	protein serine/threonine phosphatase activity
SmaCSM2_RS04510	COG0859	PFAM glycosyl transferase family 9
SmaCSM2_RS04515	COG3642	lipopolysaccharide core region biosynthetic process
SmaCSM2_RS04520	COG1234	tRNA 3'-trailer cleavage
SmaCSM2_RS04535	COG2076	Multidrug Resistance protein
SmaCSM2_RS04615	COG3047	cAMP biosynthetic process
SmaCSM2_RS04615	COG2885	chlorophyll binding
SmaCSM2_RS04725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SmaCSM2_RS04730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SmaCSM2_RS04740	COG0537	adenosine 5'-monophosphoramidase activity
SmaCSM2_RS04760	COG0714	Associated with various cellular activities
SmaCSM2_RS04775	COG1399	metal-binding, possibly nucleic acid-binding protein
SmaCSM2_RS04780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SmaCSM2_RS04785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SmaCSM2_RS04795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SmaCSM2_RS04810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SmaCSM2_RS04815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SmaCSM2_RS04820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SmaCSM2_RS04825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SmaCSM2_RS04865	COG4774	siderophore transport
SmaCSM2_RS04875	COG2223	nitrite transmembrane transporter activity
SmaCSM2_RS04890	COG2226	methyltransferase
SmaCSM2_RS04895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SmaCSM2_RS04900	COG0697	spore germination
SmaCSM2_RS04905	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS04910	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS04915	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS04920	COG0477	Major facilitator Superfamily
SmaCSM2_RS04960	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS04990	COG0667	Aldo Keto reductase
SmaCSM2_RS05010	COG0456	acetyltransferase
SmaCSM2_RS05020	COG0519	Catalyzes the synthesis of GMP from XMP
SmaCSM2_RS05025	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SmaCSM2_RS05030	COG1678	Uncharacterized ACR, COG1678
SmaCSM2_RS05035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SmaCSM2_RS05040	COG0540	Belongs to the ATCase OTCase family
SmaCSM2_RS05060	COG2239	Acts as a magnesium transporter
SmaCSM2_RS05065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SmaCSM2_RS05080	COG1660	Displays ATPase and GTPase activities
SmaCSM2_RS05085	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SmaCSM2_RS05090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SmaCSM2_RS05095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SmaCSM2_RS05105	COG1137	ATPase activity
SmaCSM2_RS05120	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SmaCSM2_RS05135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SmaCSM2_RS05155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SmaCSM2_RS05175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SmaCSM2_RS05185	COG0628	permease
SmaCSM2_RS05195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SmaCSM2_RS05205	COG2261	transglycosylase associated protein
SmaCSM2_RS05215	COG1555	photosystem II stabilization
SmaCSM2_RS05235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SmaCSM2_RS05240	COG1477	protein flavinylation
SmaCSM2_RS05260	COG4771	TonB-dependent receptor
SmaCSM2_RS05270	COG3128	pkhd-type hydroxylase
SmaCSM2_RS05280	COG4774	siderophore transport
SmaCSM2_RS05290	COG2146	nitrite reductase [NAD(P)H] activity
SmaCSM2_RS05305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SmaCSM2_RS05310	COG0719	Fe-S assembly protein
SmaCSM2_RS05315	COG0396	ATPase activity
SmaCSM2_RS05320	COG0719	Fe-S assembly protein
SmaCSM2_RS05325	COG1959	2 iron, 2 sulfur cluster binding
SmaCSM2_RS05335	COG0693	protein deglycase activity
SmaCSM2_RS05360	COG1764	response to oxidative stress
SmaCSM2_RS05365	COG0384	phenazine biosynthesis protein PhzF
SmaCSM2_RS05370	COG0384	phenazine biosynthesis protein PhzF
SmaCSM2_RS05375	COG0527	aspartate kinase activity
SmaCSM2_RS05385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SmaCSM2_RS05400	COG0142	geranyltranstransferase activity
SmaCSM2_RS05405	COG0366	Alpha amylase catalytic
SmaCSM2_RS05415	COG1082	Xylose isomerase domain protein TIM barrel
SmaCSM2_RS05425	COG2190	(PTS) system
SmaCSM2_RS05425	COG2211	Major facilitator Superfamily
SmaCSM2_RS05455	COG1131	(ABC) transporter
SmaCSM2_RS05465	COG0629	single-stranded DNA binding
SmaCSM2_RS05495	COG2010	Cytochrome c
SmaCSM2_RS05505	COG0673	inositol 2-dehydrogenase activity
SmaCSM2_RS05510	COG2211	Major facilitator Superfamily
SmaCSM2_RS05520	COG1609	Transcriptional regulator
SmaCSM2_RS05550	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS05555	COG1073	alpha beta
SmaCSM2_RS05580	COG3655	Transcriptional regulator
SmaCSM2_RS05585	COG1253	flavin adenine dinucleotide binding
SmaCSM2_RS05590	COG1408	metallophosphoesterase
SmaCSM2_RS05620	COG2259	Doxx family
SmaCSM2_RS05650	COG0477	Major facilitator Superfamily
SmaCSM2_RS05665	COG1802	Transcriptional regulator
SmaCSM2_RS05700	COG3052	prosthetic group binding
SmaCSM2_RS05715	COG0579	oxidoreductase
SmaCSM2_RS05740	COG3104	oligopeptide transport
SmaCSM2_RS05745	COG1297	OPT oligopeptide transporter protein
SmaCSM2_RS05750	COG1506	peptidase
SmaCSM2_RS05750	COG0823	Involved in the tonB-independent uptake of proteins
SmaCSM2_RS05765	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SmaCSM2_RS05770	COG2894	cell division
SmaCSM2_RS05775	COG0850	regulation of cytokinetic process
SmaCSM2_RS05785	COG4585	Histidine kinase
SmaCSM2_RS05790	COG2197	response regulator
SmaCSM2_RS05830	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SmaCSM2_RS05840	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SmaCSM2_RS05850	COG1595	DNA-templated transcription, initiation
SmaCSM2_RS05860	COG1946	Acyl-CoA thioesterase
SmaCSM2_RS05880	COG0824	Thioesterase
SmaCSM2_RS05885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SmaCSM2_RS05890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SmaCSM2_RS05895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SmaCSM2_RS05900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SmaCSM2_RS05905	COG0268	Binds directly to 16S ribosomal RNA
SmaCSM2_RS05910	COG0728	peptidoglycan biosynthetic process
SmaCSM2_RS05915	COG0196	riboflavin kinase activity
SmaCSM2_RS05920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SmaCSM2_RS05930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SmaCSM2_RS05955	COG4206	TonB-dependent receptor
SmaCSM2_RS05975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SmaCSM2_RS06005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SmaCSM2_RS06010	COG1845	cytochrome c oxidase, subunit III
SmaCSM2_RS06015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SmaCSM2_RS06030	COG0326	Molecular chaperone. Has ATPase activity
SmaCSM2_RS06050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SmaCSM2_RS06055	COG2070	2-Nitropropane dioxygenase
SmaCSM2_RS06065	COG0228	four-way junction DNA binding
SmaCSM2_RS06070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SmaCSM2_RS06075	COG0336	Belongs to the RNA methyltransferase TrmD family
SmaCSM2_RS06080	COG0335	large ribosomal subunit rRNA binding
SmaCSM2_RS06100	COG0534	Mate efflux family protein
SmaCSM2_RS06120	COG0753	catalase activity
SmaCSM2_RS06135	COG2831	hemolysin activation secretion protein
SmaCSM2_RS06160	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS06165	COG3134	Outer membrane lipoprotein
SmaCSM2_RS06180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS06200	COG0024	Methionine aminopeptidase
SmaCSM2_RS06225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SmaCSM2_RS06275	COG2814	Major facilitator Superfamily
SmaCSM2_RS06280	COG3706	GGDEF domain
SmaCSM2_RS06300	COG0588	phosphoglycerate mutase activity
SmaCSM2_RS06310	COG3590	peptidase
SmaCSM2_RS06320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SmaCSM2_RS06330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SmaCSM2_RS06335	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS06340	COG2205	protein histidine kinase activity
SmaCSM2_RS06345	COG4452	Inner membrane protein CreD
SmaCSM2_RS06360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SmaCSM2_RS06365	COG0735	belongs to the Fur family
SmaCSM2_RS06405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SmaCSM2_RS06445	COG5001	Diguanylate cyclase
SmaCSM2_RS06445	COG5002	protein histidine kinase activity
SmaCSM2_RS06455	COG1187	pseudouridine synthase activity
SmaCSM2_RS06465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SmaCSM2_RS06490	COG1132	(ABC) transporter
SmaCSM2_RS06540	COG1695	Transcriptional regulator
SmaCSM2_RS06560	COG1981	membrane
SmaCSM2_RS06565	COG0825	malonyl-CoA metabolic process
SmaCSM2_RS06585	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SmaCSM2_RS06590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SmaCSM2_RS06600	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SmaCSM2_RS06605	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SmaCSM2_RS06610	COG0750	zinc metalloprotease
SmaCSM2_RS06615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SmaCSM2_RS06620	COG0575	Belongs to the CDS family
SmaCSM2_RS06625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SmaCSM2_RS06630	COG0233	cytoplasmic translational termination
SmaCSM2_RS06635	COG0528	UMP kinase activity
SmaCSM2_RS06645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SmaCSM2_RS06650	COG0052	Belongs to the universal ribosomal protein uS2 family
SmaCSM2_RS06670	COG3188	usher protein
SmaCSM2_RS06690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SmaCSM2_RS06705	COG1393	Belongs to the ArsC family
SmaCSM2_RS06710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SmaCSM2_RS06720	COG0367	asparagine synthase
SmaCSM2_RS06725	COG0475	glutathione-regulated potassium exporter activity
SmaCSM2_RS06760	COG1566	PFAM secretion protein HlyD family protein
SmaCSM2_RS06765	COG2814	Major facilitator Superfamily
SmaCSM2_RS06775	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS06795	COG0557	exoribonuclease II activity
SmaCSM2_RS06805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SmaCSM2_RS06810	COG1538	Outer membrane efflux protein
SmaCSM2_RS06815	COG1136	(ABC) transporter
SmaCSM2_RS06815	COG0577	efflux transmembrane transporter activity
SmaCSM2_RS06820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS06850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SmaCSM2_RS06855	COG2259	Doxx family
SmaCSM2_RS06865	COG3220	belongs to the UPF0276 family
SmaCSM2_RS06875	COG0704	Plays a role in the regulation of phosphate uptake
SmaCSM2_RS06885	COG0581	inorganic phosphate transmembrane transporter activity
SmaCSM2_RS06890	COG0573	inorganic phosphate transmembrane transporter activity
SmaCSM2_RS06895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SmaCSM2_RS06900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SmaCSM2_RS06910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SmaCSM2_RS06920	COG1024	Enoyl-CoA hydratase
SmaCSM2_RS06930	COG0494	nUDIX hydrolase
SmaCSM2_RS06950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SmaCSM2_RS06950	COG0116	Belongs to the methyltransferase superfamily
SmaCSM2_RS06970	COG2733	membrane
SmaCSM2_RS06980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SmaCSM2_RS06985	COG1012	belongs to the aldehyde dehydrogenase family
SmaCSM2_RS06990	COG0477	Major facilitator Superfamily
SmaCSM2_RS06995	COG2703	oxygen carrier activity
SmaCSM2_RS07025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmaCSM2_RS07035	COG0174	glutamine synthetase
SmaCSM2_RS07045	COG3842	ATPase activity
SmaCSM2_RS07050	COG1176	ABC-type spermidine putrescine transport system, permease component I
SmaCSM2_RS07055	COG1177	transmembrane transport
SmaCSM2_RS07060	COG1012	belongs to the aldehyde dehydrogenase family
SmaCSM2_RS07075	COG4535	Mg2 and Co2 transporter CorC
SmaCSM2_RS07090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SmaCSM2_RS07095	COG1702	phosphate starvation-inducible protein PhoH
SmaCSM2_RS07105	COG1131	(ABC) transporter
SmaCSM2_RS07110	COG0842	Transport permease protein
SmaCSM2_RS07115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SmaCSM2_RS07130	COG0741	lytic transglycosylase activity
SmaCSM2_RS07135	COG0723	plastoquinol--plastocyanin reductase activity
SmaCSM2_RS07140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SmaCSM2_RS07145	COG2857	Cytochrome c1
SmaCSM2_RS07150	COG0625	glutathione transferase activity
SmaCSM2_RS07155	COG2969	positive regulation of protein catabolic process
SmaCSM2_RS07190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SmaCSM2_RS07200	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SmaCSM2_RS07215	COG1611	Belongs to the LOG family
SmaCSM2_RS07260	COG0556	nucleotide-excision repair
SmaCSM2_RS07285	COG3713	MltA-interacting MipA family protein
SmaCSM2_RS07290	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS07300	COG2333	competence protein COMEC
SmaCSM2_RS07300	COG0658	competence protein
SmaCSM2_RS07305	COG0811	peptide transport
SmaCSM2_RS07320	COG1663	tetraacyldisaccharide 4'-kinase activity
SmaCSM2_RS07325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SmaCSM2_RS07330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SmaCSM2_RS07340	COG0322	excinuclease ABC activity
SmaCSM2_RS07375	COG0577	efflux transmembrane transporter activity
SmaCSM2_RS07375	COG1136	(ABC) transporter
SmaCSM2_RS07400	COG0582	viral genome integration into host DNA
SmaCSM2_RS07405	COG2837	iron assimilation
SmaCSM2_RS07420	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS07430	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS07485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SmaCSM2_RS07490	COG1252	NADH dehydrogenase
SmaCSM2_RS07495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SmaCSM2_RS07500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SmaCSM2_RS07500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SmaCSM2_RS07560	COG2003	Belongs to the UPF0758 family
SmaCSM2_RS07750	COG0270	DNA (cytosine-5-)-methyltransferase activity
SmaCSM2_RS07755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SmaCSM2_RS07760	COG0629	single-stranded DNA binding
SmaCSM2_RS07825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SmaCSM2_RS07850	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS07870	COG4977	sequence-specific DNA binding
SmaCSM2_RS07870	COG1917	Cupin 2, conserved barrel domain protein
SmaCSM2_RS07875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SmaCSM2_RS07910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SmaCSM2_RS07925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SmaCSM2_RS07930	COG0069	glutamate synthase activity
SmaCSM2_RS07960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SmaCSM2_RS07975	COG1253	flavin adenine dinucleotide binding
SmaCSM2_RS07995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SmaCSM2_RS08010	COG0504	CTP synthase activity
SmaCSM2_RS08015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SmaCSM2_RS08030	COG0148	phosphopyruvate hydratase activity
SmaCSM2_RS08035	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SmaCSM2_RS08040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SmaCSM2_RS08045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SmaCSM2_RS08055	COG2840	Smr protein MutS2
SmaCSM2_RS08060	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SmaCSM2_RS08065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SmaCSM2_RS08090	COG1534	Rna-binding protein
SmaCSM2_RS08095	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SmaCSM2_RS08100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SmaCSM2_RS08110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SmaCSM2_RS08115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SmaCSM2_RS08120	COG1923	regulation of RNA biosynthetic process
SmaCSM2_RS08125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SmaCSM2_RS08130	COG1546	Belongs to the CinA family
SmaCSM2_RS08135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SmaCSM2_RS08140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SmaCSM2_RS08145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SmaCSM2_RS08150	COG2137	regulation of response to DNA damage stimulus
SmaCSM2_RS08155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SmaCSM2_RS08160	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SmaCSM2_RS08200	COG3540	Alkaline phosphatase
SmaCSM2_RS08215	COG3258	Cytochrome c
SmaCSM2_RS08230	COG2223	nitrite transmembrane transporter activity
SmaCSM2_RS08235	COG0596	Alpha beta hydrolase
SmaCSM2_RS08245	COG1741	Belongs to the pirin family
SmaCSM2_RS08250	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS08280	COG0352	thiamine-phosphate diphosphorylase activity
SmaCSM2_RS08280	COG0351	phosphomethylpyrimidine kinase
SmaCSM2_RS08295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SmaCSM2_RS08300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SmaCSM2_RS08310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SmaCSM2_RS08320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SmaCSM2_RS08325	COG0477	Major facilitator Superfamily
SmaCSM2_RS08335	COG0617	tRNA 3'-terminal CCA addition
SmaCSM2_RS08340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SmaCSM2_RS08345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SmaCSM2_RS08350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SmaCSM2_RS08360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SmaCSM2_RS08365	COG0166	Belongs to the GPI family
SmaCSM2_RS08370	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SmaCSM2_RS08380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SmaCSM2_RS08385	COG0671	phosphoesterase, PA-phosphatase related
SmaCSM2_RS08395	COG0800	Aldolase
SmaCSM2_RS08400	COG0129	dihydroxy-acid dehydratase activity
SmaCSM2_RS08410	COG0837	glucose binding
SmaCSM2_RS08415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SmaCSM2_RS08435	COG2009	succinate dehydrogenase
SmaCSM2_RS08440	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SmaCSM2_RS08445	COG1053	succinate dehydrogenase
SmaCSM2_RS08465	COG4591	ABC-type transport system involved in lipoprotein release permease component
SmaCSM2_RS08480	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SmaCSM2_RS08490	COG0552	protein localization to endoplasmic reticulum
SmaCSM2_RS08505	COG0742	ribosomal rna small subunit methyltransferase
SmaCSM2_RS08510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SmaCSM2_RS08520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SmaCSM2_RS08525	COG0405	Gamma-glutamyltransferase
SmaCSM2_RS08530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SmaCSM2_RS08550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SmaCSM2_RS08570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SmaCSM2_RS08580	COG0415	Belongs to the DNA photolyase family
SmaCSM2_RS08585	COG2885	chlorophyll binding
SmaCSM2_RS08590	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS08650	COG2124	cytochrome p450
SmaCSM2_RS08675	COG2197	response regulator
SmaCSM2_RS08700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SmaCSM2_RS08715	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SmaCSM2_RS08720	COG0735	belongs to the Fur family
SmaCSM2_RS08730	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS08735	COG0497	DNA recombination
SmaCSM2_RS08740	COG1420	regulation of RNA biosynthetic process
SmaCSM2_RS08745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SmaCSM2_RS08750	COG0443	Heat shock 70 kDa protein
SmaCSM2_RS08755	COG0484	heat shock protein binding
SmaCSM2_RS08760	COG2207	Transcriptional regulator
SmaCSM2_RS08765	COG2223	nitrite transmembrane transporter activity
SmaCSM2_RS08775	COG1605	Chorismate mutase
SmaCSM2_RS08775	COG0287	Prephenate dehydrogenase
SmaCSM2_RS08785	COG1132	(ABC) transporter
SmaCSM2_RS08805	COG5001	Diguanylate cyclase
SmaCSM2_RS08815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SmaCSM2_RS08820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SmaCSM2_RS08825	COG0343	queuine tRNA-ribosyltransferase activity
SmaCSM2_RS08830	COG1862	Preprotein translocase
SmaCSM2_RS08840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SmaCSM2_RS08850	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SmaCSM2_RS08860	COG2081	HI0933 family
SmaCSM2_RS08865	COG4681	YaeQ
SmaCSM2_RS08870	COG0564	pseudouridine synthase activity
SmaCSM2_RS08880	COG1278	Cold shock
SmaCSM2_RS08885	COG0625	glutathione transferase activity
SmaCSM2_RS08890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SmaCSM2_RS08895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SmaCSM2_RS08900	COG0513	Belongs to the DEAD box helicase family
SmaCSM2_RS08920	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS08925	COG0488	(ABC) transporter
SmaCSM2_RS08965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SmaCSM2_RS08970	COG2957	Belongs to the agmatine deiminase family
SmaCSM2_RS08980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SmaCSM2_RS08985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SmaCSM2_RS08995	COG0776	regulation of translation
SmaCSM2_RS09005	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SmaCSM2_RS09020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SmaCSM2_RS09025	COG0183	Belongs to the thiolase family
SmaCSM2_RS09030	COG1250	3-hydroxyacyl-CoA dehydrogenase
SmaCSM2_RS09030	COG1024	Enoyl-CoA hydratase
SmaCSM2_RS09040	COG0105	UTP biosynthetic process
SmaCSM2_RS09045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SmaCSM2_RS09050	COG0457	Tetratricopeptide repeat
SmaCSM2_RS09050	COG0859	PFAM glycosyl transferase family 9
SmaCSM2_RS09055	COG1426	Protein conserved in bacteria
SmaCSM2_RS09060	COG2976	Protein conserved in bacteria
SmaCSM2_RS09065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SmaCSM2_RS09070	COG1160	GTP binding
SmaCSM2_RS09075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SmaCSM2_RS09080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SmaCSM2_RS09080	COG0475	glutathione-regulated potassium exporter activity
SmaCSM2_RS09095	COG0519	Catalyzes the synthesis of GMP from XMP
SmaCSM2_RS09095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SmaCSM2_RS09125	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS09165	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS09180	COG0596	Alpha beta hydrolase
SmaCSM2_RS09195	COG0640	Transcriptional regulator
SmaCSM2_RS09210	COG4716	Myosin-crossreactive antigen
SmaCSM2_RS09215	COG0300	oxidoreductase activity
SmaCSM2_RS09220	COG2207	Transcriptional regulator
SmaCSM2_RS09250	COG0431	NADPH-dependent FMN reductase
SmaCSM2_RS09260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SmaCSM2_RS09265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SmaCSM2_RS09270	COG1473	amidohydrolase
SmaCSM2_RS09280	COG1126	abc transporter atp-binding protein
SmaCSM2_RS09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SmaCSM2_RS09310	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SmaCSM2_RS09315	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS09335	COG1309	transcriptional regulator
SmaCSM2_RS09350	COG0697	spore germination
SmaCSM2_RS09355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SmaCSM2_RS09360	COG0167	dihydroorotate dehydrogenase activity
SmaCSM2_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS09380	COG1012	belongs to the aldehyde dehydrogenase family
SmaCSM2_RS09390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SmaCSM2_RS09435	COG4191	Histidine kinase
SmaCSM2_RS09435	COG0784	Response regulator, receiver
SmaCSM2_RS09440	COG3850	Histidine kinase
SmaCSM2_RS09440	COG2205	protein histidine kinase activity
SmaCSM2_RS09440	COG4999	Histidine kinase
SmaCSM2_RS09440	COG3437	response regulator, receiver
SmaCSM2_RS09445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SmaCSM2_RS09455	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS09465	COG0640	Transcriptional regulator
SmaCSM2_RS09500	COG0460	homoserine dehydrogenase
SmaCSM2_RS09500	COG0527	aspartate kinase activity
SmaCSM2_RS09515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SmaCSM2_RS09520	COG0124	histidyl-tRNA synthetase
SmaCSM2_RS09535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SmaCSM2_RS09540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SmaCSM2_RS09545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SmaCSM2_RS09550	COG0131	Imidazoleglycerol-phosphate dehydratase
SmaCSM2_RS09550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SmaCSM2_RS09555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SmaCSM2_RS09560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SmaCSM2_RS09565	COG0107	imidazoleglycerol-phosphate synthase activity
SmaCSM2_RS09570	COG0140	phosphoribosyl-ATP diphosphatase activity
SmaCSM2_RS09570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SmaCSM2_RS09590	COG1446	asparaginase
SmaCSM2_RS09595	COG3142	Participates in the control of copper homeostasis
SmaCSM2_RS09615	COG0789	Transcriptional regulator
SmaCSM2_RS09635	COG3537	Alpha-1,2-mannosidase
SmaCSM2_RS09640	COG1609	Transcriptional regulator
SmaCSM2_RS09650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SmaCSM2_RS09665	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SmaCSM2_RS09670	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SmaCSM2_RS09675	COG0235	Class ii aldolase
SmaCSM2_RS09685	COG0531	amino acid
SmaCSM2_RS09690	COG0531	amino acid
SmaCSM2_RS09705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SmaCSM2_RS09710	COG0277	FAD linked oxidase domain protein
SmaCSM2_RS09725	COG2205	protein histidine kinase activity
SmaCSM2_RS09730	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS09735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS09740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmaCSM2_RS09760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SmaCSM2_RS09805	COG2249	NAD(P)H dehydrogenase (quinone) activity
SmaCSM2_RS09820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SmaCSM2_RS09825	COG0505	Belongs to the CarA family
SmaCSM2_RS09830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SmaCSM2_RS09835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SmaCSM2_RS09845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SmaCSM2_RS09855	COG4676	Protein conserved in bacteria
SmaCSM2_RS09885	COG1012	belongs to the aldehyde dehydrogenase family
SmaCSM2_RS09905	COG2205	protein histidine kinase activity
SmaCSM2_RS09905	COG2198	Histidine kinase
SmaCSM2_RS09905	COG0784	Response regulator, receiver
SmaCSM2_RS09915	COG1024	Enoyl-CoA hydratase
SmaCSM2_RS09920	COG0318	PFAM AMP-dependent synthetase and ligase
SmaCSM2_RS09925	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SmaCSM2_RS09930	COG1012	belongs to the aldehyde dehydrogenase family
SmaCSM2_RS09935	COG1309	transcriptional regulator
SmaCSM2_RS09940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SmaCSM2_RS09980	COG2267	carboxylic ester hydrolase activity
SmaCSM2_RS09990	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SmaCSM2_RS10000	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS10015	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS10025	COG0835	chemotaxis
SmaCSM2_RS10030	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SmaCSM2_RS10035	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS10045	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS10055	COG0835	chemotaxis
SmaCSM2_RS10065	COG1360	Flagellar Motor Protein
SmaCSM2_RS10070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SmaCSM2_RS10075	COG0784	Response regulator, receiver
SmaCSM2_RS10075	COG0643	Histidine kinase
SmaCSM2_RS10075	COG2198	Histidine kinase
SmaCSM2_RS10080	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SmaCSM2_RS10105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SmaCSM2_RS10110	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SmaCSM2_RS10125	COG1987	bacterial-type flagellum assembly
SmaCSM2_RS10135	COG3190	flagellar
SmaCSM2_RS10185	COG1677	Flagellar hook-basal body complex protein FliE
SmaCSM2_RS10210	COG2197	response regulator
SmaCSM2_RS10230	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SmaCSM2_RS10255	COG1256	bacterial-type flagellum assembly
SmaCSM2_RS10270	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SmaCSM2_RS10280	COG4787	bacterial-type flagellum-dependent cell motility
SmaCSM2_RS10300	COG1815	bacterial-type flagellum-dependent cell motility
SmaCSM2_RS10305	COG0835	chemotaxis
SmaCSM2_RS10305	COG0784	Response regulator, receiver
SmaCSM2_RS10325	COG5002	protein histidine kinase activity
SmaCSM2_RS10365	COG2915	High frequency lysogenization protein hflD homolog
SmaCSM2_RS10370	COG0482	sulfurtransferase activity
SmaCSM2_RS10385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SmaCSM2_RS10395	COG0542	response to heat
SmaCSM2_RS10405	COG3093	addiction module antidote protein HigA
SmaCSM2_RS10440	COG0492	ferredoxin-NADP+ reductase activity
SmaCSM2_RS10445	COG1674	ftsk spoiiie
SmaCSM2_RS10460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SmaCSM2_RS10465	COG3152	Membrane
SmaCSM2_RS10475	COG2819	hydrolase of the alpha beta superfamily
SmaCSM2_RS10485	COG4558	Periplasmic binding protein
SmaCSM2_RS10490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SmaCSM2_RS10495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SmaCSM2_RS10505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SmaCSM2_RS10520	COG0784	Response regulator, receiver
SmaCSM2_RS10520	COG5002	protein histidine kinase activity
SmaCSM2_RS10540	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SmaCSM2_RS10555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SmaCSM2_RS10565	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SmaCSM2_RS10580	COG1595	DNA-templated transcription, initiation
SmaCSM2_RS10600	COG0784	Response regulator, receiver
SmaCSM2_RS10605	COG4251	negative regulation of phosphorylation
SmaCSM2_RS10615	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SmaCSM2_RS10715	COG0789	Transcriptional regulator
SmaCSM2_RS10720	COG2608	mercury ion transmembrane transporter activity
SmaCSM2_RS10725	COG2608	mercury ion transmembrane transporter activity
SmaCSM2_RS10735	COG0789	Transcriptional regulator
SmaCSM2_RS10750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SmaCSM2_RS10755	COG4644	lycopene metabolic process
SmaCSM2_RS10795	COG2217	Heavy metal translocating P-type atpase
SmaCSM2_RS10810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS10815	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmaCSM2_RS10830	COG0010	Belongs to the arginase family
SmaCSM2_RS10885	COG2132	Multicopper oxidase
SmaCSM2_RS10910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SmaCSM2_RS10965	COG4644	lycopene metabolic process
SmaCSM2_RS10990	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS11005	COG1902	pentaerythritol trinitrate reductase activity
SmaCSM2_RS11020	COG1309	transcriptional regulator
SmaCSM2_RS11050	COG2205	protein histidine kinase activity
SmaCSM2_RS11070	COG1104	cysteine desulfurase activity
SmaCSM2_RS11170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SmaCSM2_RS11175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SmaCSM2_RS11180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SmaCSM2_RS11185	COG2080	2 iron, 2 sulfur cluster binding
SmaCSM2_RS11250	COG0649	NAD binding
SmaCSM2_RS11260	COG1609	Transcriptional regulator
SmaCSM2_RS11265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SmaCSM2_RS11265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SmaCSM2_RS11270	COG1105	Belongs to the carbohydrate kinase PfkB family
SmaCSM2_RS11275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SmaCSM2_RS11275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SmaCSM2_RS11290	COG1733	regulation of RNA biosynthetic process
SmaCSM2_RS11335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SmaCSM2_RS11350	COG2828	Protein conserved in bacteria
SmaCSM2_RS11355	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS11375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SmaCSM2_RS11380	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS11435	COG2205	protein histidine kinase activity
SmaCSM2_RS11445	COG0318	PFAM AMP-dependent synthetase and ligase
SmaCSM2_RS11490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SmaCSM2_RS11510	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS11535	COG2204	response regulator
SmaCSM2_RS11615	COG3604	Transcriptional regulator
SmaCSM2_RS11620	COG2084	Dehydrogenase
SmaCSM2_RS11670	COG3447	MASE1 domain protein
SmaCSM2_RS11670	COG5001	Diguanylate cyclase
SmaCSM2_RS11670	COG5002	protein histidine kinase activity
SmaCSM2_RS11680	COG1136	(ABC) transporter
SmaCSM2_RS11680	COG0577	efflux transmembrane transporter activity
SmaCSM2_RS11685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS11695	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS11700	COG2205	protein histidine kinase activity
SmaCSM2_RS11710	COG3214	Protein conserved in bacteria
SmaCSM2_RS11720	COG4774	siderophore transport
SmaCSM2_RS11750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SmaCSM2_RS11755	COG1285	pathogenesis
SmaCSM2_RS11760	COG4191	Histidine kinase
SmaCSM2_RS11765	COG4566	intracellular signal transduction
SmaCSM2_RS11840	COG0243	molybdopterin cofactor binding
SmaCSM2_RS11865	COG0477	Major facilitator Superfamily
SmaCSM2_RS11890	COG1136	(ABC) transporter
SmaCSM2_RS11905	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS11910	COG0656	L-ascorbic acid biosynthetic process
SmaCSM2_RS11930	COG5002	protein histidine kinase activity
SmaCSM2_RS11935	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS11940	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS11970	COG3537	Alpha-1,2-mannosidase
SmaCSM2_RS12000	COG0477	Major facilitator Superfamily
SmaCSM2_RS12020	COG3920	Histidine kinase
SmaCSM2_RS12020	COG2202	Pas domain
SmaCSM2_RS12065	COG1335	isochorismatase
SmaCSM2_RS12070	COG1335	isochorismatase
SmaCSM2_RS12100	COG0811	peptide transport
SmaCSM2_RS12235	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS12245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SmaCSM2_RS12250	COG4149	molybdate abc transporter
SmaCSM2_RS12255	COG0725	ABC transporter, periplasmic molybdate-binding protein
SmaCSM2_RS12260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SmaCSM2_RS12275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SmaCSM2_RS12280	COG2181	nitrate reductase activity
SmaCSM2_RS12285	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SmaCSM2_RS12290	COG1140	nitrate reductase beta subunit
SmaCSM2_RS12295	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SmaCSM2_RS12300	COG2223	nitrite transmembrane transporter activity
SmaCSM2_RS12310	COG0746	molybdenum cofactor guanylyltransferase activity
SmaCSM2_RS12315	COG0314	molybdopterin synthase activity
SmaCSM2_RS12325	COG0303	'Molybdopterin
SmaCSM2_RS12330	COG0521	Mo-molybdopterin cofactor biosynthetic process
SmaCSM2_RS12330	COG0315	cyclic pyranopterin monophosphate synthase activity
SmaCSM2_RS12335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SmaCSM2_RS12380	COG0789	Transcriptional regulator
SmaCSM2_RS12385	COG0431	NADPH-dependent FMN reductase
SmaCSM2_RS12395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SmaCSM2_RS12400	COG0798	PFAM Bile acid sodium symporter
SmaCSM2_RS12480	COG1943	Transposase
SmaCSM2_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS12490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SmaCSM2_RS12490	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SmaCSM2_RS12495	COG1535	isochorismatase
SmaCSM2_RS12495	COG3433	isochorismatase activity
SmaCSM2_RS12500	COG3433	isochorismatase activity
SmaCSM2_RS12500	COG1535	isochorismatase
SmaCSM2_RS12505	COG1021	2,3-dihydroxybenzoate-AMP ligase
SmaCSM2_RS12510	COG1169	isochorismate synthase
SmaCSM2_RS12520	COG2409	Drug exporters of the RND superfamily
SmaCSM2_RS12525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SmaCSM2_RS12580	COG1321	iron dependent repressor
SmaCSM2_RS12585	COG1914	H( )-stimulated, divalent metal cation uptake system
SmaCSM2_RS12600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SmaCSM2_RS12605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SmaCSM2_RS12615	COG4206	TonB-dependent receptor
SmaCSM2_RS12620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SmaCSM2_RS12665	COG4772	TonB-dependent receptor
SmaCSM2_RS12685	COG2226	methyltransferase
SmaCSM2_RS12730	COG4964	Belongs to the GSP D family
SmaCSM2_RS12785	COG2814	Major facilitator Superfamily
SmaCSM2_RS12795	COG1228	amidohydrolase
SmaCSM2_RS12805	COG1335	isochorismatase
SmaCSM2_RS12820	COG3850	Histidine kinase
SmaCSM2_RS12825	COG2197	response regulator
SmaCSM2_RS12840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SmaCSM2_RS12850	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS12865	COG3161	chorismate lyase activity
SmaCSM2_RS12900	COG0277	FAD linked oxidase domain protein
SmaCSM2_RS12905	COG1304	FMN binding
SmaCSM2_RS12910	COG2186	Transcriptional regulator
SmaCSM2_RS12920	COG1285	pathogenesis
SmaCSM2_RS13000	COG0587	DNA-directed DNA polymerase activity
SmaCSM2_RS13015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SmaCSM2_RS13020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SmaCSM2_RS13020	COG0519	Catalyzes the synthesis of GMP from XMP
SmaCSM2_RS13035	COG1595	DNA-templated transcription, initiation
SmaCSM2_RS13045	COG1629	transport
SmaCSM2_RS13045	COG4206	TonB-dependent receptor
SmaCSM2_RS13075	COG0531	amino acid
SmaCSM2_RS13090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SmaCSM2_RS13100	COG0789	Transcriptional regulator
SmaCSM2_RS13155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SmaCSM2_RS13210	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS13215	COG5002	protein histidine kinase activity
SmaCSM2_RS13215	COG5001	Diguanylate cyclase
SmaCSM2_RS13215	COG3447	MASE1 domain protein
SmaCSM2_RS13220	COG2183	response to ionizing radiation
SmaCSM2_RS13250	COG3243	poly(R)-hydroxyalkanoic acid synthase
SmaCSM2_RS13265	COG2226	methyltransferase
SmaCSM2_RS13265	COG1073	alpha beta
SmaCSM2_RS13270	COG0534	Mate efflux family protein
SmaCSM2_RS13290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SmaCSM2_RS13300	COG0668	transmembrane transport
SmaCSM2_RS13305	COG1902	pentaerythritol trinitrate reductase activity
SmaCSM2_RS13315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SmaCSM2_RS13325	COG1733	regulation of RNA biosynthetic process
SmaCSM2_RS13330	COG2249	NAD(P)H dehydrogenase (quinone) activity
SmaCSM2_RS13335	COG0456	acetyltransferase
SmaCSM2_RS13405	COG3702	type iv secretory pathway
SmaCSM2_RS13425	COG2948	multi-organism process
SmaCSM2_RS13435	COG3736	Type IV secretory pathway, component VirB8
SmaCSM2_RS13445	COG3505	Type IV secretory pathway VirD4
SmaCSM2_RS13455	COG2814	Major facilitator Superfamily
SmaCSM2_RS13495	COG4774	siderophore transport
SmaCSM2_RS13525	COG0577	efflux transmembrane transporter activity
SmaCSM2_RS13525	COG1136	(ABC) transporter
SmaCSM2_RS13560	COG1733	regulation of RNA biosynthetic process
SmaCSM2_RS13565	COG0604	alcohol dehydrogenase
SmaCSM2_RS13580	COG0210	DNA helicase
SmaCSM2_RS13605	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS13610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SmaCSM2_RS13620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SmaCSM2_RS13635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SmaCSM2_RS13640	COG1605	Chorismate mutase
SmaCSM2_RS13640	COG0077	Prephenate dehydratase
SmaCSM2_RS13645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SmaCSM2_RS13690	COG1228	amidohydrolase
SmaCSM2_RS13705	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SmaCSM2_RS13760	COG2957	Belongs to the agmatine deiminase family
SmaCSM2_RS13765	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS13810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmaCSM2_RS13840	COG4993	Dehydrogenase
SmaCSM2_RS13850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SmaCSM2_RS13860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SmaCSM2_RS13870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SmaCSM2_RS13875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SmaCSM2_RS13890	COG0359	binds to the 23S rRNA
SmaCSM2_RS13895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SmaCSM2_RS13900	COG0360	Binds together with S18 to 16S ribosomal RNA
SmaCSM2_RS13910	COG0316	Belongs to the HesB IscA family
SmaCSM2_RS13915	COG0017	Asparaginyl-tRNA synthetase
SmaCSM2_RS13935	COG0288	reversible hydration of carbon dioxide
SmaCSM2_RS13945	COG3844	kynureninase activity
SmaCSM2_RS13950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SmaCSM2_RS13955	COG2925	Exonuclease
SmaCSM2_RS13965	COG0667	Aldo Keto reductase
SmaCSM2_RS13985	COG2902	Dehydrogenase
SmaCSM2_RS13995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS14000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmaCSM2_RS14015	COG1960	acyl-CoA dehydrogenase activity
SmaCSM2_RS14030	COG0646	methionine synthase
SmaCSM2_RS14030	COG1410	methionine synthase
SmaCSM2_RS14045	COG2900	Belongs to the SlyX family
SmaCSM2_RS14060	COG0386	Belongs to the glutathione peroxidase family
SmaCSM2_RS14070	COG1725	Transcriptional regulator
SmaCSM2_RS14075	COG1131	(ABC) transporter
SmaCSM2_RS14110	COG2850	peptidyl-arginine hydroxylation
SmaCSM2_RS14120	COG0567	Dehydrogenase, E1 component
SmaCSM2_RS14135	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS14155	COG3540	Alkaline phosphatase
SmaCSM2_RS14165	COG0305	Participates in initiation and elongation during chromosome replication
SmaCSM2_RS14175	COG0367	asparagine synthase
SmaCSM2_RS14185	COG0625	glutathione transferase activity
SmaCSM2_RS14205	COG0084	hydrolase, TatD family'
SmaCSM2_RS14210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SmaCSM2_RS14245	COG0625	glutathione transferase activity
SmaCSM2_RS14260	COG1595	DNA-templated transcription, initiation
SmaCSM2_RS14265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SmaCSM2_RS14280	COG0386	Belongs to the glutathione peroxidase family
SmaCSM2_RS14285	COG0339	signal peptide processing
SmaCSM2_RS14290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SmaCSM2_RS14310	COG0705	Rhomboid family
SmaCSM2_RS14315	COG3104	oligopeptide transport
SmaCSM2_RS14325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SmaCSM2_RS14330	COG4290	ribonuclease
SmaCSM2_RS14345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SmaCSM2_RS14345	COG0316	Belongs to the HesB IscA family
SmaCSM2_RS14350	COG2154	pterin-4-alpha-carbinolamine dehydratase
SmaCSM2_RS14360	COG0428	transporter
SmaCSM2_RS14370	COG1530	ribonuclease E activity
SmaCSM2_RS14385	COG0395	ABC-type sugar transport system, permease component
SmaCSM2_RS14410	COG1609	Transcriptional regulator
SmaCSM2_RS14415	COG0271	Belongs to the BolA IbaG family
SmaCSM2_RS14420	COG2350	Protein conserved in bacteria
SmaCSM2_RS14425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SmaCSM2_RS14430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SmaCSM2_RS14435	COG1187	pseudouridine synthase activity
SmaCSM2_RS14445	COG2814	Major facilitator Superfamily
SmaCSM2_RS14465	COG0436	Aminotransferase
SmaCSM2_RS14470	COG4133	protoheme IX ABC transporter activity
SmaCSM2_RS14490	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SmaCSM2_RS14505	COG3088	subunit of a heme lyase
SmaCSM2_RS14505	COG4235	cytochrome complex assembly
SmaCSM2_RS14515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SmaCSM2_RS14525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SmaCSM2_RS14530	COG4988	ABC transporter
SmaCSM2_RS14540	COG1294	oxidase, subunit
SmaCSM2_RS14570	COG1649	PFAM Uncharacterised BCR, COG1649
SmaCSM2_RS14570	COG0726	polysaccharide deacetylase
SmaCSM2_RS14575	COG1215	transferase activity, transferring glycosyl groups
SmaCSM2_RS14585	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SmaCSM2_RS14600	COG0165	Argininosuccinate lyase
SmaCSM2_RS14605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SmaCSM2_RS14615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SmaCSM2_RS14620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SmaCSM2_RS14625	COG0137	argininosuccinate synthase activity
SmaCSM2_RS14630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SmaCSM2_RS14645	COG2166	iron-sulfur cluster assembly
SmaCSM2_RS14665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SmaCSM2_RS14685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SmaCSM2_RS14690	COG0402	S-adenosylhomocysteine deaminase activity
SmaCSM2_RS14695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SmaCSM2_RS14705	COG5001	Diguanylate cyclase
SmaCSM2_RS14705	COG3300	MHYT domain
SmaCSM2_RS14725	COG0501	Belongs to the peptidase M48B family
SmaCSM2_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS14755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SmaCSM2_RS14760	COG0860	N-Acetylmuramoyl-L-alanine amidase
SmaCSM2_RS14765	COG0802	atpase or kinase
SmaCSM2_RS14770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SmaCSM2_RS14770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SmaCSM2_RS14775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SmaCSM2_RS14780	COG1570	exodeoxyribonuclease VII activity
SmaCSM2_RS14795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SmaCSM2_RS14810	COG4771	TonB-dependent receptor
SmaCSM2_RS14825	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS14830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SmaCSM2_RS14830	COG2169	Transcriptional regulator
SmaCSM2_RS14835	COG2130	NADP-dependent
SmaCSM2_RS14860	COG1960	acyl-CoA dehydrogenase activity
SmaCSM2_RS14870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SmaCSM2_RS14885	COG2197	response regulator
SmaCSM2_RS14945	COG1309	transcriptional regulator
SmaCSM2_RS14950	COG2076	Multidrug Resistance protein
SmaCSM2_RS14955	COG5487	UPF0391 membrane protein
SmaCSM2_RS14960	COG1280	lysine exporter protein (LysE YggA)
SmaCSM2_RS14965	COG1794	racemase activity, acting on amino acids and derivatives
SmaCSM2_RS15005	COG0776	regulation of translation
SmaCSM2_RS15010	COG0072	phenylalanine-tRNA ligase activity
SmaCSM2_RS15010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SmaCSM2_RS15015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SmaCSM2_RS15020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SmaCSM2_RS15025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SmaCSM2_RS15030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SmaCSM2_RS15035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SmaCSM2_RS15065	COG1185	polyribonucleotide nucleotidyltransferase activity
SmaCSM2_RS15070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SmaCSM2_RS15080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SmaCSM2_RS15085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SmaCSM2_RS15090	COG0195	Participates in both transcription termination and antitermination
SmaCSM2_RS15095	COG0779	Required for maturation of 30S ribosomal subunits
SmaCSM2_RS15110	COG1007	ATP synthesis coupled electron transport
SmaCSM2_RS15125	COG0713	ATP synthesis coupled electron transport
SmaCSM2_RS15135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SmaCSM2_RS15140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SmaCSM2_RS15155	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SmaCSM2_RS15160	COG0649	NAD binding
SmaCSM2_RS15165	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SmaCSM2_RS15170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SmaCSM2_RS15175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SmaCSM2_RS15190	COG0149	triose-phosphate isomerase activity
SmaCSM2_RS15200	COG3119	arylsulfatase activity
SmaCSM2_RS15205	COG0438	transferase activity, transferring glycosyl groups
SmaCSM2_RS15210	COG0726	polysaccharide deacetylase
SmaCSM2_RS15215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SmaCSM2_RS15225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SmaCSM2_RS15230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SmaCSM2_RS15235	COG0159	tryptophan synthase activity
SmaCSM2_RS15245	COG0133	tryptophan synthase activity
SmaCSM2_RS15280	COG0135	phosphoribosylanthranilate isomerase activity
SmaCSM2_RS15285	COG0101	tRNA pseudouridine synthase activity
SmaCSM2_RS15300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SmaCSM2_RS15305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SmaCSM2_RS15310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SmaCSM2_RS15315	COG2890	protein-(glutamine-N5) methyltransferase activity
SmaCSM2_RS15320	COG1999	signal sequence binding
SmaCSM2_RS15325	COG0688	phosphatidylethanolamine metabolic process
SmaCSM2_RS15340	COG0433	COG0433 Predicted ATPase
SmaCSM2_RS15345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SmaCSM2_RS15355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SmaCSM2_RS15405	COG0412	Dienelactone hydrolase
SmaCSM2_RS15415	COG0717	Belongs to the dCTP deaminase family
SmaCSM2_RS15420	COG0489	protein tyrosine kinase activity
SmaCSM2_RS15425	COG4771	TonB-dependent receptor
SmaCSM2_RS15430	COG4771	TonB-dependent receptor
SmaCSM2_RS15435	COG4206	TonB-dependent receptor
SmaCSM2_RS15440	COG3590	peptidase
SmaCSM2_RS15470	COG0697	spore germination
SmaCSM2_RS15480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SmaCSM2_RS15485	COG2311	Membrane
SmaCSM2_RS15490	COG1047	Peptidyl-prolyl cis-trans
SmaCSM2_RS15495	COG0791	NLP P60 protein
SmaCSM2_RS15500	COG0791	NLP P60 protein
SmaCSM2_RS15505	COG1301	dicarboxylic acid transport
SmaCSM2_RS15520	COG2801	Transposase and inactivated derivatives
SmaCSM2_RS15535	COG1722	exodeoxyribonuclease VII activity
SmaCSM2_RS15540	COG0142	geranyltranstransferase activity
SmaCSM2_RS15550	COG0312	modulator of DNA gyrase
SmaCSM2_RS15555	COG3028	Belongs to the UPF0307 family
SmaCSM2_RS15560	COG0312	modulator of DNA gyrase
SmaCSM2_RS15580	COG2968	Membrane
SmaCSM2_RS15590	COG4771	TonB-dependent receptor
SmaCSM2_RS15605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SmaCSM2_RS15615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SmaCSM2_RS15630	COG0495	leucyl-tRNA aminoacylation
SmaCSM2_RS15645	COG3118	belongs to the thioredoxin family
SmaCSM2_RS15655	COG2203	Gaf domain
SmaCSM2_RS15655	COG3706	GGDEF domain
SmaCSM2_RS15655	COG4251	negative regulation of phosphorylation
SmaCSM2_RS15655	COG5001	Diguanylate cyclase
SmaCSM2_RS15680	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SmaCSM2_RS15690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmaCSM2_RS15695	COG0346	lactoylglutathione lyase activity
SmaCSM2_RS15705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SmaCSM2_RS15705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SmaCSM2_RS15715	COG2878	Part of a membrane complex involved in electron transport
SmaCSM2_RS15720	COG0251	oxidation-reduction process
SmaCSM2_RS15725	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SmaCSM2_RS15725	COG0392	lysyltransferase activity
SmaCSM2_RS15755	COG2824	Alkylphosphonate utilization operon protein PhnA
SmaCSM2_RS15760	COG0443	Heat shock 70 kDa protein
SmaCSM2_RS15800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SmaCSM2_RS15805	COG3122	Protein conserved in bacteria
SmaCSM2_RS15810	COG1451	nucleotide metabolic process
SmaCSM2_RS15820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SmaCSM2_RS15840	COG0183	Belongs to the thiolase family
SmaCSM2_RS15855	COG1960	acyl-CoA dehydrogenase activity
SmaCSM2_RS15865	COG1793	dna ligase
SmaCSM2_RS15870	COG1201	RNA secondary structure unwinding
SmaCSM2_RS15885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SmaCSM2_RS15890	COG1278	Cold shock
SmaCSM2_RS15895	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SmaCSM2_RS15900	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SmaCSM2_RS15905	COG1472	Belongs to the glycosyl hydrolase 3 family
SmaCSM2_RS15910	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SmaCSM2_RS15915	COG2954	triphosphatase activity
SmaCSM2_RS15920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SmaCSM2_RS15930	COG1381	Involved in DNA repair and RecF pathway recombination
SmaCSM2_RS15935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SmaCSM2_RS15950	COG0681	Belongs to the peptidase S26 family
SmaCSM2_RS15955	COG0481	GTPase activity
SmaCSM2_RS15960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SmaCSM2_RS15980	COG1741	Belongs to the pirin family
SmaCSM2_RS15985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SmaCSM2_RS15995	COG1741	Belongs to the pirin family
SmaCSM2_RS16005	COG1966	Carbon starvation protein
SmaCSM2_RS16010	COG2879	small protein
SmaCSM2_RS16020	COG2205	protein histidine kinase activity
SmaCSM2_RS16060	COG2814	Major facilitator Superfamily
SmaCSM2_RS16065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SmaCSM2_RS16065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SmaCSM2_RS16075	COG1113	amino acid transport
SmaCSM2_RS16080	COG2207	Transcriptional regulator
SmaCSM2_RS16080	COG1917	Cupin 2, conserved barrel domain protein
SmaCSM2_RS16105	COG1376	ErfK ybiS ycfS ynhG family protein
SmaCSM2_RS16110	COG0739	heme binding
SmaCSM2_RS16120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SmaCSM2_RS16130	COG0330	HflC and HflK could
SmaCSM2_RS16135	COG0330	HflC and HflK could
SmaCSM2_RS16140	COG0604	alcohol dehydrogenase
SmaCSM2_RS16155	COG0678	peroxiredoxin activity
SmaCSM2_RS16165	COG4953	penicillin-binding protein 1C
SmaCSM2_RS16170	COG2373	Large extracellular alpha-helical protein
SmaCSM2_RS16175	COG2079	MmgE PrpD family protein
SmaCSM2_RS16180	COG2828	Protein conserved in bacteria
SmaCSM2_RS16190	COG3609	addiction module antidote protein, CC2985 family
SmaCSM2_RS16225	COG0259	pyridoxamine-phosphate oxidase activity
SmaCSM2_RS16240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SmaCSM2_RS16260	COG0477	Major facilitator Superfamily
SmaCSM2_RS16270	COG2198	Histidine kinase
SmaCSM2_RS16270	COG0784	Response regulator, receiver
SmaCSM2_RS16270	COG2205	protein histidine kinase activity
SmaCSM2_RS16280	COG3038	cytochrome b561
SmaCSM2_RS16295	COG1760	l-serine dehydratase
SmaCSM2_RS16305	COG0460	homoserine dehydrogenase
SmaCSM2_RS16305	COG0527	aspartate kinase activity
SmaCSM2_RS16310	COG0626	cystathionine gamma-synthase activity
SmaCSM2_RS16315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SmaCSM2_RS16320	COG0739	heme binding
SmaCSM2_RS16325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SmaCSM2_RS16330	COG1272	protein, Hemolysin III
SmaCSM2_RS16335	COG2982	Protein involved in outer membrane biogenesis
SmaCSM2_RS16345	COG0463	Glycosyl transferase, family 2
SmaCSM2_RS16350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SmaCSM2_RS16355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SmaCSM2_RS16365	COG4206	TonB-dependent receptor
SmaCSM2_RS16370	COG1309	transcriptional regulator
SmaCSM2_RS16410	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS16420	COG0509	glycine decarboxylation via glycine cleavage system
SmaCSM2_RS16425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SmaCSM2_RS16435	COG1742	UPF0060 membrane protein
SmaCSM2_RS16440	COG3956	TIGRFAM MazG family protein
SmaCSM2_RS16445	COG1218	3'(2'),5'-bisphosphate nucleotidase
SmaCSM2_RS16450	COG0494	nUDIX hydrolase
SmaCSM2_RS16460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SmaCSM2_RS16470	COG2201	protein-glutamate methylesterase activity
SmaCSM2_RS16475	COG2198	Histidine kinase
SmaCSM2_RS16475	COG0784	Response regulator, receiver
SmaCSM2_RS16475	COG0643	Histidine kinase
SmaCSM2_RS16480	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS16485	COG0835	chemotaxis
SmaCSM2_RS16500	COG0189	ligase activity
SmaCSM2_RS16510	COG1214	PFAM Peptidase M22, glycoprotease
SmaCSM2_RS16515	COG1199	ATP-dependent helicase activity
SmaCSM2_RS16525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SmaCSM2_RS16540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SmaCSM2_RS16550	COG1643	Atp-dependent helicase
SmaCSM2_RS16555	COG0783	Belongs to the Dps family
SmaCSM2_RS16560	COG0514	ATP-dependent DNA helicase (RecQ)
SmaCSM2_RS16570	COG2132	Multicopper oxidase
SmaCSM2_RS16655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SmaCSM2_RS16660	COG0602	queuosine metabolic process
SmaCSM2_RS16670	COG2885	chlorophyll binding
SmaCSM2_RS16675	COG0823	Involved in the tonB-independent uptake of proteins
SmaCSM2_RS16690	COG0811	peptide transport
SmaCSM2_RS16695	COG0824	Thioesterase
SmaCSM2_RS16700	COG2255	four-way junction helicase activity
SmaCSM2_RS16710	COG0632	four-way junction helicase activity
SmaCSM2_RS16715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SmaCSM2_RS16720	COG0217	transcriptional regulatory protein
SmaCSM2_RS16740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SmaCSM2_RS16775	COG0488	(ABC) transporter
SmaCSM2_RS16785	COG4651	solute:proton antiporter activity
SmaCSM2_RS16785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SmaCSM2_RS16795	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS16800	COG2205	protein histidine kinase activity
SmaCSM2_RS16810	COG0542	response to heat
SmaCSM2_RS16830	COG0028	Belongs to the TPP enzyme family
SmaCSM2_RS16855	COG3387	PFAM Glycoside hydrolase 15-related
SmaCSM2_RS16860	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SmaCSM2_RS16865	COG3011	Protein conserved in bacteria
SmaCSM2_RS16880	COG0564	pseudouridine synthase activity
SmaCSM2_RS16885	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SmaCSM2_RS16895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SmaCSM2_RS16895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SmaCSM2_RS16905	COG0045	succinate-CoA ligase (ADP-forming) activity
SmaCSM2_RS16930	COG4969	Belongs to the N-Me-Phe pilin family
SmaCSM2_RS16945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SmaCSM2_RS16960	COG2205	protein histidine kinase activity
SmaCSM2_RS16965	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS16985	COG0189	ligase activity
SmaCSM2_RS17005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmaCSM2_RS17020	COG3240	lipase activity
SmaCSM2_RS17020	COG4625	pathogenesis
SmaCSM2_RS17030	COG2022	thiamine diphosphate biosynthetic process
SmaCSM2_RS17035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SmaCSM2_RS17040	COG0471	metal ion transport
SmaCSM2_RS17040	COG3273	potassium ion transport
SmaCSM2_RS17060	COG1970	mechanosensitive ion channel activity
SmaCSM2_RS17075	COG1115	amino acid carrier protein
SmaCSM2_RS17085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SmaCSM2_RS17090	COG1115	amino acid carrier protein
SmaCSM2_RS17095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SmaCSM2_RS17100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmaCSM2_RS17105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS17145	COG3588	fructose-bisphosphate aldolase
SmaCSM2_RS17150	COG0469	pyruvate kinase activity
SmaCSM2_RS17160	COG0126	phosphoglycerate kinase activity
SmaCSM2_RS17175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SmaCSM2_RS17220	COG3093	addiction module antidote protein HigA
SmaCSM2_RS17230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SmaCSM2_RS17235	COG1301	dicarboxylic acid transport
SmaCSM2_RS17265	COG0714	Associated with various cellular activities
SmaCSM2_RS17295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SmaCSM2_RS17310	COG5295	Hep Hag repeat protein
SmaCSM2_RS17350	COG0254	rRNA binding
SmaCSM2_RS17360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SmaCSM2_RS17370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SmaCSM2_RS17375	COG1758	RNA polymerase activity
SmaCSM2_RS17385	COG0243	molybdopterin cofactor binding
SmaCSM2_RS17385	COG3383	formate dehydrogenase (NAD+) activity
SmaCSM2_RS17390	COG3383	formate dehydrogenase (NAD+) activity
SmaCSM2_RS17390	COG0243	molybdopterin cofactor binding
SmaCSM2_RS17395	COG0437	4 iron, 4 sulfur cluster binding
SmaCSM2_RS17400	COG2864	formate dehydrogenase
SmaCSM2_RS17410	COG1921	L-seryl-tRNASec selenium transferase activity
SmaCSM2_RS17415	COG3276	selenocysteine insertion sequence binding
SmaCSM2_RS17425	COG0709	Synthesizes selenophosphate from selenide and ATP
SmaCSM2_RS17430	COG1561	YicC-like family, N-terminal region
SmaCSM2_RS17435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SmaCSM2_RS17440	COG0346	lactoylglutathione lyase activity
SmaCSM2_RS17450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SmaCSM2_RS17465	COG0006	proline dipeptidase activity
SmaCSM2_RS17470	COG0006	proline dipeptidase activity
SmaCSM2_RS17475	COG3079	Belongs to the UPF0149 family
SmaCSM2_RS17495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SmaCSM2_RS17505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SmaCSM2_RS17515	COG2912	Transglutaminase-like superfamily
SmaCSM2_RS17520	COG1773	rubredoxin
SmaCSM2_RS17530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SmaCSM2_RS17535	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
SmaCSM2_RS17545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SmaCSM2_RS17550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SmaCSM2_RS17565	COG4221	oxidoreductase activity
SmaCSM2_RS17590	COG0671	phosphoesterase, PA-phosphatase related
SmaCSM2_RS17600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SmaCSM2_RS17605	COG0563	adenylate kinase activity
SmaCSM2_RS17630	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SmaCSM2_RS17640	COG0848	biopolymer transport protein
SmaCSM2_RS17650	COG2832	Protein of unknown function (DUF454)
SmaCSM2_RS17690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SmaCSM2_RS17715	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS17725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SmaCSM2_RS17730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SmaCSM2_RS17735	COG0405	Gamma-glutamyltransferase
SmaCSM2_RS17740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SmaCSM2_RS17760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SmaCSM2_RS17765	COG2226	methyltransferase
SmaCSM2_RS17775	COG0066	3-isopropylmalate dehydratase activity
SmaCSM2_RS17780	COG0473	3-isopropylmalate dehydrogenase activity
SmaCSM2_RS17795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmaCSM2_RS17800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS17810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SmaCSM2_RS17815	COG1538	Outer membrane efflux protein
SmaCSM2_RS17820	COG0531	amino acid
SmaCSM2_RS17825	COG1519	Transferase
SmaCSM2_RS17830	COG1560	Kdo2-lipid A biosynthetic process
SmaCSM2_RS17835	COG1943	Transposase
SmaCSM2_RS17870	COG1301	dicarboxylic acid transport
SmaCSM2_RS17880	COG4191	Histidine kinase
SmaCSM2_RS17895	COG0642	Histidine kinase
SmaCSM2_RS17910	COG2851	Citrate transporter
SmaCSM2_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS17930	COG1162	GTPase activity
SmaCSM2_RS17935	COG0436	Aminotransferase
SmaCSM2_RS17955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SmaCSM2_RS17970	COG1228	amidohydrolase
SmaCSM2_RS17975	COG0804	urea catabolic process
SmaCSM2_RS17985	COG1307	EDD domain protein, DegV family
SmaCSM2_RS18025	COG4251	negative regulation of phosphorylation
SmaCSM2_RS18025	COG3706	GGDEF domain
SmaCSM2_RS18025	COG2203	Gaf domain
SmaCSM2_RS18025	COG5001	Diguanylate cyclase
SmaCSM2_RS18030	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SmaCSM2_RS18040	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SmaCSM2_RS18055	COG1902	pentaerythritol trinitrate reductase activity
SmaCSM2_RS18075	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS18080	COG1064	alcohol dehydrogenase
SmaCSM2_RS18100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SmaCSM2_RS18105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SmaCSM2_RS18120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SmaCSM2_RS18135	COG1522	sequence-specific DNA binding
SmaCSM2_RS18145	COG4773	Receptor
SmaCSM2_RS18180	COG0617	tRNA 3'-terminal CCA addition
SmaCSM2_RS18205	COG3468	outer membrane autotransporter barrel domain protein
SmaCSM2_RS18215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SmaCSM2_RS18220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SmaCSM2_RS18225	COG1609	Transcriptional regulator
SmaCSM2_RS18235	COG0837	glucose binding
SmaCSM2_RS18245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SmaCSM2_RS18265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SmaCSM2_RS18275	COG4191	Histidine kinase
SmaCSM2_RS18280	COG0784	Response regulator, receiver
SmaCSM2_RS18285	COG4251	negative regulation of phosphorylation
SmaCSM2_RS18290	COG2823	Periplasmic or secreted lipoprotein
SmaCSM2_RS18295	COG0673	inositol 2-dehydrogenase activity
SmaCSM2_RS18300	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SmaCSM2_RS18320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SmaCSM2_RS18325	COG0321	lipoyl(octanoyl) transferase activity
SmaCSM2_RS18330	COG2921	Belongs to the UPF0250 family
SmaCSM2_RS18340	COG1686	Belongs to the peptidase S11 family
SmaCSM2_RS18345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SmaCSM2_RS18350	COG2951	lytic endotransglycosylase activity
SmaCSM2_RS18355	COG0772	Belongs to the SEDS family
SmaCSM2_RS18360	COG0772	Belongs to the SEDS family
SmaCSM2_RS18375	COG1792	Involved in formation and maintenance of cell shape
SmaCSM2_RS18380	COG1077	Cell shape determining protein MreB Mrl
SmaCSM2_RS18385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SmaCSM2_RS18400	COG0308	aminopeptidase N
SmaCSM2_RS18405	COG2226	methyltransferase
SmaCSM2_RS18435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmaCSM2_RS18440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS18455	COG0673	inositol 2-dehydrogenase activity
SmaCSM2_RS18465	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SmaCSM2_RS18485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SmaCSM2_RS18495	COG2832	Protein of unknown function (DUF454)
SmaCSM2_RS18505	COG0436	Aminotransferase
SmaCSM2_RS18510	COG1505	serine-type exopeptidase activity
SmaCSM2_RS18545	COG0697	spore germination
SmaCSM2_RS18550	COG1666	GTP binding
SmaCSM2_RS18565	COG0339	signal peptide processing
SmaCSM2_RS18575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SmaCSM2_RS18595	COG1132	(ABC) transporter
SmaCSM2_RS18620	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SmaCSM2_RS18630	COG0577	efflux transmembrane transporter activity
SmaCSM2_RS18630	COG1136	(ABC) transporter
SmaCSM2_RS18635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SmaCSM2_RS18645	COG1136	(ABC) transporter
SmaCSM2_RS18665	COG4191	Histidine kinase
SmaCSM2_RS18675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SmaCSM2_RS18685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SmaCSM2_RS18690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SmaCSM2_RS18695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SmaCSM2_RS18700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SmaCSM2_RS18705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SmaCSM2_RS18710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SmaCSM2_RS18720	COG0356	it plays a direct role in the translocation of protons across the membrane
SmaCSM2_RS18735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SmaCSM2_RS18740	COG0508	dehydrogenase complex catalyzes the overall conversion of
SmaCSM2_RS18760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SmaCSM2_RS18785	COG0181	hydroxymethylbilane synthase activity
SmaCSM2_RS18805	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS18805	COG2972	Histidine kinase
SmaCSM2_RS18810	COG0400	carboxylic ester hydrolase activity
SmaCSM2_RS18830	COG4771	TonB-dependent receptor
SmaCSM2_RS18840	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS18930	COG0625	glutathione transferase activity
SmaCSM2_RS18945	COG2259	Doxx family
SmaCSM2_RS18970	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SmaCSM2_RS18995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SmaCSM2_RS19000	COG1490	D-aminoacyl-tRNA deacylase activity
SmaCSM2_RS19045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SmaCSM2_RS19045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SmaCSM2_RS19050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SmaCSM2_RS19055	COG0242	peptide deformylase activity
SmaCSM2_RS19065	COG0758	DNA mediated transformation
SmaCSM2_RS19070	COG2922	Belongs to the Smg family
SmaCSM2_RS19080	COG1714	RDD family
SmaCSM2_RS19085	COG1754	DNA topoisomerase type I activity
SmaCSM2_RS19085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SmaCSM2_RS19090	COG0009	L-threonylcarbamoyladenylate synthase
SmaCSM2_RS19105	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS19115	COG0616	signal peptide processing
SmaCSM2_RS19120	COG0534	Mate efflux family protein
SmaCSM2_RS19135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SmaCSM2_RS19140	COG0625	glutathione transferase activity
SmaCSM2_RS19150	COG1252	NADH dehydrogenase
SmaCSM2_RS19170	COG2860	membrane
SmaCSM2_RS19175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SmaCSM2_RS19190	COG1846	Transcriptional regulator
SmaCSM2_RS19220	COG0459	protein refolding
SmaCSM2_RS19225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SmaCSM2_RS19230	COG2356	endonuclease I
SmaCSM2_RS19235	COG1324	tolerance protein
SmaCSM2_RS19245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SmaCSM2_RS19255	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS19275	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS19285	COG1785	Belongs to the alkaline phosphatase family
SmaCSM2_RS19290	COG1686	Belongs to the peptidase S11 family
SmaCSM2_RS19300	COG2249	NAD(P)H dehydrogenase (quinone) activity
SmaCSM2_RS19310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SmaCSM2_RS19320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SmaCSM2_RS19330	COG0511	ligase activity, forming carbon-carbon bonds
SmaCSM2_RS19335	COG0439	Biotin carboxylase
SmaCSM2_RS19350	COG2264	protein methyltransferase activity
SmaCSM2_RS19360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
SmaCSM2_RS19365	COG4589	Belongs to the CDS family
SmaCSM2_RS19370	COG0204	Acyl-transferase
SmaCSM2_RS19380	COG2453	phosphatase
SmaCSM2_RS19380	COG0671	phosphoesterase, PA-phosphatase related
SmaCSM2_RS19385	COG2267	carboxylic ester hydrolase activity
SmaCSM2_RS19390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SmaCSM2_RS19395	COG0138	bifunctional purine biosynthesis protein purh
SmaCSM2_RS19405	COG0151	Belongs to the GarS family
SmaCSM2_RS19420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SmaCSM2_RS19425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SmaCSM2_RS19430	COG2201	protein-glutamate methylesterase activity
SmaCSM2_RS19435	COG2177	Part of the ABC transporter FtsEX involved in
SmaCSM2_RS19440	COG2884	Cell division ATP-binding protein ftsE
SmaCSM2_RS19455	COG3118	belongs to the thioredoxin family
SmaCSM2_RS19460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SmaCSM2_RS19465	COG3706	GGDEF domain
SmaCSM2_RS19475	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
SmaCSM2_RS19515	COG1652	LysM domain
SmaCSM2_RS19520	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SmaCSM2_RS19520	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SmaCSM2_RS19535	COG1473	amidohydrolase
SmaCSM2_RS19540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS19545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmaCSM2_RS19550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmaCSM2_RS19555	COG1289	transmembrane transporter activity
SmaCSM2_RS19560	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS19565	COG2814	Major facilitator Superfamily
SmaCSM2_RS19595	COG0316	Belongs to the HesB IscA family
SmaCSM2_RS19620	COG5002	protein histidine kinase activity
SmaCSM2_RS19620	COG2205	protein histidine kinase activity
SmaCSM2_RS19620	COG0784	Response regulator, receiver
SmaCSM2_RS19635	COG1051	belongs to the nudix hydrolase family
SmaCSM2_RS19650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SmaCSM2_RS19655	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SmaCSM2_RS19660	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SmaCSM2_RS19670	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SmaCSM2_RS19675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SmaCSM2_RS19680	COG0730	response to heat
SmaCSM2_RS19690	COG0134	indole-3-glycerol-phosphate synthase activity
SmaCSM2_RS19695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SmaCSM2_RS19715	COG1597	lipid kinase activity
SmaCSM2_RS19730	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SmaCSM2_RS19735	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SmaCSM2_RS19745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SmaCSM2_RS19745	COG2111	Na H antiporter
SmaCSM2_RS19750	COG1006	Multisubunit Na H antiporter MnhC subunit
SmaCSM2_RS19755	COG0651	ATP synthesis coupled electron transport
SmaCSM2_RS19760	COG1863	multisubunit Na H antiporter MnhE subunit
SmaCSM2_RS19765	COG2212	antiporter activity
SmaCSM2_RS19770	COG1320	monovalent cation:proton antiporter activity
SmaCSM2_RS19775	COG0530	calcium, potassium:sodium antiporter activity
SmaCSM2_RS19790	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SmaCSM2_RS19815	COG3104	oligopeptide transport
SmaCSM2_RS19820	COG3483	tryptophan 2,3-dioxygenase activity
SmaCSM2_RS19850	COG2378	regulation of single-species biofilm formation
SmaCSM2_RS19855	COG0702	epimerase
SmaCSM2_RS19865	COG2354	Protein conserved in bacteria
SmaCSM2_RS19870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SmaCSM2_RS19875	COG1368	sulfuric ester hydrolase activity
SmaCSM2_RS19880	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SmaCSM2_RS19880	COG3264	Mechanosensitive ion channel
SmaCSM2_RS19895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SmaCSM2_RS19930	COG1166	arginine decarboxylase activity
SmaCSM2_RS19935	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SmaCSM2_RS19955	COG2960	long-chain fatty acid transporting porin activity
SmaCSM2_RS19970	COG2814	Major facilitator Superfamily
SmaCSM2_RS20000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SmaCSM2_RS20005	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS20100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SmaCSM2_RS20100	COG3453	Protein conserved in bacteria
SmaCSM2_RS20115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SmaCSM2_RS20135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SmaCSM2_RS20150	COG0431	NADPH-dependent FMN reductase
SmaCSM2_RS20165	COG0798	PFAM Bile acid sodium symporter
SmaCSM2_RS20180	COG0659	secondary active sulfate transmembrane transporter activity
SmaCSM2_RS20185	COG0604	alcohol dehydrogenase
SmaCSM2_RS20190	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS20195	COG4221	oxidoreductase activity
SmaCSM2_RS20250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SmaCSM2_RS20250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SmaCSM2_RS20265	COG1902	pentaerythritol trinitrate reductase activity
SmaCSM2_RS20330	COG0402	S-adenosylhomocysteine deaminase activity
SmaCSM2_RS20375	COG0561	phosphatase activity
SmaCSM2_RS20380	COG3932	Exopolysaccharide synthesis, ExoD
SmaCSM2_RS20410	COG1999	signal sequence binding
SmaCSM2_RS20415	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SmaCSM2_RS20420	COG1845	cytochrome c oxidase, subunit III
SmaCSM2_RS20430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SmaCSM2_RS20435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SmaCSM2_RS20450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SmaCSM2_RS20455	COG1104	cysteine desulfurase activity
SmaCSM2_RS20500	COG2031	fatty acid transporter
SmaCSM2_RS20520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SmaCSM2_RS20570	COG0673	inositol 2-dehydrogenase activity
SmaCSM2_RS20580	COG1501	Belongs to the glycosyl hydrolase 31 family
SmaCSM2_RS20585	COG2222	sugar isomerase
SmaCSM2_RS20590	COG1940	carbohydrate kinase activity
SmaCSM2_RS20600	COG1349	DNA-binding transcription factor activity
SmaCSM2_RS20605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SmaCSM2_RS20610	COG2814	Major facilitator Superfamily
SmaCSM2_RS20645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SmaCSM2_RS20650	COG0156	8-amino-7-oxononanoate synthase activity
SmaCSM2_RS20655	COG2267	carboxylic ester hydrolase activity
SmaCSM2_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS20675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SmaCSM2_RS20700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SmaCSM2_RS20705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SmaCSM2_RS20710	COG2205	protein histidine kinase activity
SmaCSM2_RS20715	COG0745	RESPONSE REGULATOR receiver
SmaCSM2_RS20720	COG3541	Predicted nucleotidyltransferase
SmaCSM2_RS20725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SmaCSM2_RS20750	COG0714	Associated with various cellular activities
SmaCSM2_RS20765	COG0754	glutathionylspermidine amidase activity
SmaCSM2_RS20780	COG0129	dihydroxy-acid dehydratase activity
SmaCSM2_RS20785	COG2311	Membrane
SmaCSM2_RS20790	COG1199	ATP-dependent helicase activity
SmaCSM2_RS20800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SmaCSM2_RS20820	COG3781	membrane
SmaCSM2_RS20850	COG0625	glutathione transferase activity
SmaCSM2_RS20870	COG2207	Transcriptional regulator
SmaCSM2_RS20885	COG4555	ABC transporter
SmaCSM2_RS20915	COG0543	2 iron, 2 sulfur cluster binding
SmaCSM2_RS20915	COG0633	Ferredoxin
SmaCSM2_RS20920	COG1131	(ABC) transporter
SmaCSM2_RS20925	COG0842	Transport permease protein
SmaCSM2_RS20935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SmaCSM2_RS20945	COG0084	hydrolase, TatD family'
SmaCSM2_RS20950	COG1643	Atp-dependent helicase
SmaCSM2_RS20960	COG1187	pseudouridine synthase activity
SmaCSM2_RS20975	COG0667	Aldo Keto reductase
SmaCSM2_RS20990	COG1690	Belongs to the RtcB family
SmaCSM2_RS21005	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS21015	COG2267	carboxylic ester hydrolase activity
SmaCSM2_RS21020	COG0393	Putative heavy-metal-binding
SmaCSM2_RS21025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SmaCSM2_RS21025	COG1042	CoA-binding domain protein
SmaCSM2_RS21025	COG0045	succinate-CoA ligase (ADP-forming) activity
SmaCSM2_RS21030	COG2239	Acts as a magnesium transporter
SmaCSM2_RS21045	COG3177	Filamentation induced by cAMP protein fic
SmaCSM2_RS21045	COG0666	response to abiotic stimulus
SmaCSM2_RS21050	COG3100	YcgL domain-containing protein
SmaCSM2_RS21060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SmaCSM2_RS21065	COG1028	Short-chain dehydrogenase reductase Sdr
SmaCSM2_RS21085	COG0644	oxidoreductase
SmaCSM2_RS21105	COG2986	histidine ammonia-lyase
SmaCSM2_RS21115	COG0463	Glycosyl transferase, family 2
SmaCSM2_RS21130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SmaCSM2_RS21135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SmaCSM2_RS21150	COG1294	oxidase, subunit
SmaCSM2_RS21155	COG1271	oxidase subunit
SmaCSM2_RS21165	COG1595	DNA-templated transcription, initiation
SmaCSM2_RS21200	COG0408	coproporphyrinogen oxidase activity
SmaCSM2_RS21210	COG2323	membrane
SmaCSM2_RS21225	COG0589	response to stress
SmaCSM2_RS21255	COG0210	DNA helicase
SmaCSM2_RS21265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SmaCSM2_RS21270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SmaCSM2_RS21275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SmaCSM2_RS21290	COG0251	oxidation-reduction process
SmaCSM2_RS21325	COG0463	Glycosyl transferase, family 2
SmaCSM2_RS21340	COG1475	DNA binding
SmaCSM2_RS21345	COG1192	Involved in chromosome partitioning
SmaCSM2_RS21350	COG0357	Ribosomal RNA small subunit methyltransferase G
SmaCSM2_RS21355	COG2091	lysine biosynthetic process via aminoadipic acid
SmaCSM2_RS21395	COG1971	Probably functions as a manganese efflux pump
SmaCSM2_RS21400	COG2205	protein histidine kinase activity
SmaCSM2_RS21400	COG0784	Response regulator, receiver
SmaCSM2_RS21410	COG0443	Heat shock 70 kDa protein
SmaCSM2_RS21420	COG2911	Protein conserved in bacteria
SmaCSM2_RS21425	COG0729	surface antigen
SmaCSM2_RS21435	COG0752	glycyl-tRNA synthetase alpha subunit
SmaCSM2_RS21440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SmaCSM2_RS21445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SmaCSM2_RS21445	COG0519	Catalyzes the synthesis of GMP from XMP
SmaCSM2_RS21455	COG0805	protein transport
SmaCSM2_RS21465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SmaCSM2_RS21475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SmaCSM2_RS21485	COG0840	transmembrane signaling receptor activity
SmaCSM2_RS21515	COG3135	benzoate transporter
SmaCSM2_RS21530	COG0676	glucose-6-phosphate 1-epimerase activity
SmaCSM2_RS21535	COG2951	lytic endotransglycosylase activity
SmaCSM2_RS21540	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SmaCSM2_RS21545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SmaCSM2_RS21550	COG3706	GGDEF domain
SmaCSM2_RS21580	COG0302	gtp cyclohydrolase
SmaCSM2_RS21605	COG1289	transmembrane transporter activity
SmaCSM2_RS21620	COG1074	ATP-dependent DNA helicase activity
SmaCSM2_RS21625	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SmaCSM2_RS21630	COG1127	ABC transporter
SmaCSM2_RS21635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SmaCSM2_RS21640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SmaCSM2_RS21655	COG2853	Lipoprotein
SmaCSM2_RS21660	COG0386	Belongs to the glutathione peroxidase family
SmaCSM2_RS21670	COG1322	Protein conserved in bacteria
SmaCSM2_RS21680	COG0604	alcohol dehydrogenase
SmaCSM2_RS21685	COG0583	DNA-binding transcription factor activity
SmaCSM2_RS21700	COG0667	Aldo Keto reductase
SmaCSM2_RS21710	COG0531	amino acid
SmaCSM2_RS21720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SmaCSM2_RS21725	COG0861	Integral membrane protein TerC family
SmaCSM2_RS21735	COG0584	glycerophosphoryl diester phosphodiesterase
SmaCSM2_RS21760	COG0706	membrane insertase activity
SmaCSM2_RS21765	COG0594	ribonuclease P activity
SmaCSM2_RS21770	COG0230	Belongs to the bacterial ribosomal protein bL34 family