locus-tag	class	description
DWB40_RS00015	COG0840	transmembrane signaling receptor activity
DWB40_RS00020	COG0596	Alpha beta hydrolase
DWB40_RS00020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB40_RS00025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DWB40_RS00035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWB40_RS00045	COG0805	protein transport
DWB40_RS00055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWB40_RS00055	COG0519	Catalyzes the synthesis of GMP from XMP
DWB40_RS00060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DWB40_RS00065	COG0752	glycyl-tRNA synthetase alpha subunit
DWB40_RS00075	COG0729	surface antigen
DWB40_RS00095	COG0443	Heat shock 70 kDa protein
DWB40_RS00105	COG2205	protein histidine kinase activity
DWB40_RS00105	COG0784	Response regulator, receiver
DWB40_RS00110	COG1971	Probably functions as a manganese efflux pump
DWB40_RS00150	COG2091	lysine biosynthetic process via aminoadipic acid
DWB40_RS00155	COG0357	Ribosomal RNA small subunit methyltransferase G
DWB40_RS00160	COG1192	Involved in chromosome partitioning
DWB40_RS00165	COG1475	DNA binding
DWB40_RS00180	COG0463	Glycosyl transferase, family 2
DWB40_RS00215	COG0251	oxidation-reduction process
DWB40_RS00230	COG1819	glycosyl
DWB40_RS00235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWB40_RS00240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB40_RS00245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWB40_RS00255	COG0210	DNA helicase
DWB40_RS00280	COG0589	response to stress
DWB40_RS00295	COG2323	membrane
DWB40_RS00305	COG0408	coproporphyrinogen oxidase activity
DWB40_RS00340	COG1595	DNA-templated transcription, initiation
DWB40_RS00360	COG1271	oxidase subunit
DWB40_RS00365	COG1294	oxidase, subunit
DWB40_RS00380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB40_RS00385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB40_RS00400	COG0463	Glycosyl transferase, family 2
DWB40_RS00410	COG2986	histidine ammonia-lyase
DWB40_RS00450	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS00455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB40_RS00465	COG3100	YcgL domain-containing protein
DWB40_RS00470	COG0666	response to abiotic stimulus
DWB40_RS00470	COG3177	Filamentation induced by cAMP protein fic
DWB40_RS00480	COG2239	Acts as a magnesium transporter
DWB40_RS00485	COG0045	succinate-CoA ligase (ADP-forming) activity
DWB40_RS00485	COG1042	CoA-binding domain protein
DWB40_RS00485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB40_RS00490	COG0393	Putative heavy-metal-binding
DWB40_RS00495	COG2267	carboxylic ester hydrolase activity
DWB40_RS00505	COG2814	Major facilitator Superfamily
DWB40_RS00510	COG0583	DNA-binding transcription factor activity
DWB40_RS00515	COG0840	transmembrane signaling receptor activity
DWB40_RS00530	COG1690	Belongs to the RtcB family
DWB40_RS00545	COG0667	Aldo Keto reductase
DWB40_RS00560	COG1187	pseudouridine synthase activity
DWB40_RS00570	COG1643	Atp-dependent helicase
DWB40_RS00575	COG0084	hydrolase, TatD family'
DWB40_RS00585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DWB40_RS00595	COG0842	Transport permease protein
DWB40_RS00600	COG1131	(ABC) transporter
DWB40_RS00605	COG0633	Ferredoxin
DWB40_RS00605	COG0543	2 iron, 2 sulfur cluster binding
DWB40_RS00635	COG4555	ABC transporter
DWB40_RS00650	COG2207	Transcriptional regulator
DWB40_RS00670	COG0625	glutathione transferase activity
DWB40_RS00700	COG3781	membrane
DWB40_RS00720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DWB40_RS00730	COG1199	ATP-dependent helicase activity
DWB40_RS00735	COG0129	dihydroxy-acid dehydratase activity
DWB40_RS00745	COG0754	glutathionylspermidine amidase activity
DWB40_RS00760	COG0714	Associated with various cellular activities
DWB40_RS00785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DWB40_RS00790	COG3541	Predicted nucleotidyltransferase
DWB40_RS00795	COG0745	RESPONSE REGULATOR receiver
DWB40_RS00800	COG2205	protein histidine kinase activity
DWB40_RS00805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB40_RS00830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DWB40_RS00845	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS00850	COG2267	carboxylic ester hydrolase activity
DWB40_RS00855	COG0156	8-amino-7-oxononanoate synthase activity
DWB40_RS00860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DWB40_RS00880	COG1040	competence protein
DWB40_RS00900	COG3210	domain, Protein
DWB40_RS00940	COG2814	Major facilitator Superfamily
DWB40_RS00945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DWB40_RS00950	COG1349	DNA-binding transcription factor activity
DWB40_RS00960	COG1940	carbohydrate kinase activity
DWB40_RS00965	COG2222	sugar isomerase
DWB40_RS00970	COG1501	Belongs to the glycosyl hydrolase 31 family
DWB40_RS00980	COG0673	inositol 2-dehydrogenase activity
DWB40_RS01010	COG2031	fatty acid transporter
DWB40_RS01065	COG1104	cysteine desulfurase activity
DWB40_RS01070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB40_RS01085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB40_RS01090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DWB40_RS01100	COG1845	cytochrome c oxidase, subunit III
DWB40_RS01105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DWB40_RS01110	COG1999	signal sequence binding
DWB40_RS01140	COG3932	Exopolysaccharide synthesis, ExoD
DWB40_RS01145	COG0561	phosphatase activity
DWB40_RS01165	COG0606	chelatase, subunit chli
DWB40_RS01225	COG2960	long-chain fatty acid transporting porin activity
DWB40_RS01245	COG0596	Alpha beta hydrolase
DWB40_RS01255	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DWB40_RS01260	COG1166	arginine decarboxylase activity
DWB40_RS01295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWB40_RS01310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DWB40_RS01310	COG3264	Mechanosensitive ion channel
DWB40_RS01320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DWB40_RS01325	COG2354	Protein conserved in bacteria
DWB40_RS01340	COG2378	regulation of single-species biofilm formation
DWB40_RS01370	COG3483	tryptophan 2,3-dioxygenase activity
DWB40_RS01375	COG3104	oligopeptide transport
DWB40_RS01400	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DWB40_RS01415	COG0530	calcium, potassium:sodium antiporter activity
DWB40_RS01420	COG1320	monovalent cation:proton antiporter activity
DWB40_RS01425	COG2212	antiporter activity
DWB40_RS01430	COG1863	multisubunit Na H antiporter MnhE subunit
DWB40_RS01435	COG0651	ATP synthesis coupled electron transport
DWB40_RS01440	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB40_RS01445	COG2111	Na H antiporter
DWB40_RS01445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB40_RS01455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DWB40_RS01460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DWB40_RS01475	COG1597	lipid kinase activity
DWB40_RS01495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB40_RS01500	COG0134	indole-3-glycerol-phosphate synthase activity
DWB40_RS01510	COG0730	response to heat
DWB40_RS01515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB40_RS01520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DWB40_RS01530	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DWB40_RS01535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DWB40_RS01540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DWB40_RS01555	COG1051	belongs to the nudix hydrolase family
DWB40_RS01570	COG0784	Response regulator, receiver
DWB40_RS01570	COG2205	protein histidine kinase activity
DWB40_RS01570	COG5002	protein histidine kinase activity
DWB40_RS01595	COG0316	Belongs to the HesB IscA family
DWB40_RS01625	COG2814	Major facilitator Superfamily
DWB40_RS01630	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS01635	COG1289	transmembrane transporter activity
DWB40_RS01640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB40_RS01645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB40_RS01650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB40_RS01655	COG1473	amidohydrolase
DWB40_RS01660	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DWB40_RS01660	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DWB40_RS01665	COG1652	LysM domain
DWB40_RS01700	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DWB40_RS01710	COG3706	GGDEF domain
DWB40_RS01715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DWB40_RS01720	COG3118	belongs to the thioredoxin family
DWB40_RS01730	COG2884	Cell division ATP-binding protein ftsE
DWB40_RS01735	COG2177	Part of the ABC transporter FtsEX involved in
DWB40_RS01740	COG2201	protein-glutamate methylesterase activity
DWB40_RS01745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DWB40_RS01750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWB40_RS01765	COG0151	Belongs to the GarS family
DWB40_RS01770	COG0138	bifunctional purine biosynthesis protein purh
DWB40_RS01775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DWB40_RS01780	COG2267	carboxylic ester hydrolase activity
DWB40_RS01785	COG0671	phosphoesterase, PA-phosphatase related
DWB40_RS01785	COG2453	phosphatase
DWB40_RS01795	COG0204	Acyl-transferase
DWB40_RS01800	COG4589	Belongs to the CDS family
DWB40_RS01805	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DWB40_RS01815	COG2264	protein methyltransferase activity
DWB40_RS01830	COG0439	Biotin carboxylase
DWB40_RS01835	COG0511	ligase activity, forming carbon-carbon bonds
DWB40_RS01840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DWB40_RS01850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DWB40_RS01860	COG2249	NAD(P)H dehydrogenase (quinone) activity
DWB40_RS01870	COG1686	Belongs to the peptidase S11 family
DWB40_RS01875	COG1785	Belongs to the alkaline phosphatase family
DWB40_RS01890	COG0583	DNA-binding transcription factor activity
DWB40_RS01910	COG4585	Histidine kinase
DWB40_RS01940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB40_RS01950	COG1324	tolerance protein
DWB40_RS01955	COG2356	endonuclease I
DWB40_RS01960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DWB40_RS01965	COG0459	protein refolding
DWB40_RS01995	COG1846	Transcriptional regulator
DWB40_RS02015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DWB40_RS02020	COG2860	membrane
DWB40_RS02040	COG1252	NADH dehydrogenase
DWB40_RS02050	COG0625	glutathione transferase activity
DWB40_RS02055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DWB40_RS02070	COG0534	Mate efflux family protein
DWB40_RS02075	COG0616	signal peptide processing
DWB40_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS02100	COG0009	L-threonylcarbamoyladenylate synthase
DWB40_RS02105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWB40_RS02105	COG1754	DNA topoisomerase type I activity
DWB40_RS02110	COG1714	RDD family
DWB40_RS02125	COG2922	Belongs to the Smg family
DWB40_RS02130	COG0758	DNA mediated transformation
DWB40_RS02140	COG0242	peptide deformylase activity
DWB40_RS02145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DWB40_RS02150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB40_RS02150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DWB40_RS02185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB40_RS02195	COG1490	D-aminoacyl-tRNA deacylase activity
DWB40_RS02200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWB40_RS02220	COG2259	Doxx family
DWB40_RS02255	COG4206	TonB-dependent receptor
DWB40_RS02300	COG0477	Major facilitator Superfamily
DWB40_RS02335	COG4771	TonB-dependent receptor
DWB40_RS02345	COG0400	carboxylic ester hydrolase activity
DWB40_RS02350	COG0745	RESPONSE REGULATOR receiver
DWB40_RS02350	COG2972	Histidine kinase
DWB40_RS02360	COG0181	hydroxymethylbilane synthase activity
DWB40_RS02385	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWB40_RS02405	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB40_RS02410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB40_RS02425	COG0356	it plays a direct role in the translocation of protons across the membrane
DWB40_RS02435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DWB40_RS02440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB40_RS02445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DWB40_RS02450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DWB40_RS02455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DWB40_RS02460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DWB40_RS02465	COG3415	Transposase
DWB40_RS02465	COG2801	Transposase and inactivated derivatives
DWB40_RS02475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWB40_RS02490	COG2204	response regulator
DWB40_RS02500	COG0577	efflux transmembrane transporter activity
DWB40_RS02505	COG0577	efflux transmembrane transporter activity
DWB40_RS02505	COG1136	(ABC) transporter
DWB40_RS02510	COG1136	(ABC) transporter
DWB40_RS02520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWB40_RS02540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWB40_RS02550	COG0339	signal peptide processing
DWB40_RS02565	COG1666	GTP binding
DWB40_RS02570	COG0697	spore germination
DWB40_RS02595	COG1505	serine-type exopeptidase activity
DWB40_RS02600	COG0436	Aminotransferase
DWB40_RS02610	COG2832	Protein of unknown function (DUF454)
DWB40_RS02620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DWB40_RS02635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DWB40_RS02645	COG0673	inositol 2-dehydrogenase activity
DWB40_RS02660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB40_RS02690	COG2226	methyltransferase
DWB40_RS02695	COG0308	aminopeptidase N
DWB40_RS02710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB40_RS02715	COG1077	Cell shape determining protein MreB Mrl
DWB40_RS02720	COG1792	Involved in formation and maintenance of cell shape
DWB40_RS02735	COG0772	Belongs to the SEDS family
DWB40_RS02740	COG0772	Belongs to the SEDS family
DWB40_RS02745	COG2951	lytic endotransglycosylase activity
DWB40_RS02750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DWB40_RS02755	COG1686	Belongs to the peptidase S11 family
DWB40_RS02765	COG2921	Belongs to the UPF0250 family
DWB40_RS02775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DWB40_RS02795	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DWB40_RS02800	COG0673	inositol 2-dehydrogenase activity
DWB40_RS02805	COG2823	Periplasmic or secreted lipoprotein
DWB40_RS02810	COG4251	negative regulation of phosphorylation
DWB40_RS02815	COG0784	Response regulator, receiver
DWB40_RS02820	COG4191	Histidine kinase
DWB40_RS02835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DWB40_RS02855	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DWB40_RS02865	COG0837	glucose binding
DWB40_RS02875	COG1609	Transcriptional regulator
DWB40_RS02880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWB40_RS02885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DWB40_RS02920	COG0617	tRNA 3'-terminal CCA addition
DWB40_RS02940	COG4206	TonB-dependent receptor
DWB40_RS02945	COG4773	Receptor
DWB40_RS02955	COG1522	sequence-specific DNA binding
DWB40_RS02970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DWB40_RS02975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DWB40_RS02985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DWB40_RS02990	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DWB40_RS03010	COG1064	alcohol dehydrogenase
DWB40_RS03015	COG0583	DNA-binding transcription factor activity
DWB40_RS03040	COG1902	pentaerythritol trinitrate reductase activity
DWB40_RS03055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DWB40_RS03065	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DWB40_RS03070	COG2203	Gaf domain
DWB40_RS03070	COG3706	GGDEF domain
DWB40_RS03070	COG4251	negative regulation of phosphorylation
DWB40_RS03070	COG5001	Diguanylate cyclase
DWB40_RS03110	COG1307	EDD domain protein, DegV family
DWB40_RS03120	COG0804	urea catabolic process
DWB40_RS03125	COG1228	amidohydrolase
DWB40_RS03145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DWB40_RS03165	COG0436	Aminotransferase
DWB40_RS03170	COG1162	GTPase activity
DWB40_RS03190	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS03195	COG2851	Citrate transporter
DWB40_RS03210	COG0642	Histidine kinase
DWB40_RS03225	COG4191	Histidine kinase
DWB40_RS03235	COG1301	dicarboxylic acid transport
DWB40_RS03275	COG1560	Kdo2-lipid A biosynthetic process
DWB40_RS03280	COG1519	Transferase
DWB40_RS03285	COG0531	amino acid
DWB40_RS03290	COG1538	Outer membrane efflux protein
DWB40_RS03295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB40_RS03305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB40_RS03310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB40_RS03325	COG0473	3-isopropylmalate dehydrogenase activity
DWB40_RS03340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DWB40_RS03345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB40_RS03365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DWB40_RS03370	COG0405	Gamma-glutamyltransferase
DWB40_RS03375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB40_RS03380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DWB40_RS03415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DWB40_RS03450	COG2832	Protein of unknown function (DUF454)
DWB40_RS03460	COG0848	biopolymer transport protein
DWB40_RS03470	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DWB40_RS03490	COG0563	adenylate kinase activity
DWB40_RS03495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DWB40_RS03505	COG0671	phosphoesterase, PA-phosphatase related
DWB40_RS03525	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS03535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB40_RS03540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DWB40_RS03555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB40_RS03565	COG1773	rubredoxin
DWB40_RS03570	COG2912	Transglutaminase-like superfamily
DWB40_RS03580	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DWB40_RS03590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DWB40_RS03610	COG3079	Belongs to the UPF0149 family
DWB40_RS03615	COG0006	proline dipeptidase activity
DWB40_RS03620	COG0006	proline dipeptidase activity
DWB40_RS03635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DWB40_RS03645	COG0346	lactoylglutathione lyase activity
DWB40_RS03650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DWB40_RS03655	COG1561	YicC-like family, N-terminal region
DWB40_RS03660	COG0709	Synthesizes selenophosphate from selenide and ATP
DWB40_RS03670	COG3276	selenocysteine insertion sequence binding
DWB40_RS03675	COG1921	L-seryl-tRNASec selenium transferase activity
DWB40_RS03685	COG2864	formate dehydrogenase
DWB40_RS03690	COG0437	4 iron, 4 sulfur cluster binding
DWB40_RS03705	COG1758	RNA polymerase activity
DWB40_RS03710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWB40_RS03720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DWB40_RS03730	COG0254	rRNA binding
DWB40_RS03785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DWB40_RS03815	COG0714	Associated with various cellular activities
DWB40_RS03845	COG1301	dicarboxylic acid transport
DWB40_RS03850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DWB40_RS03895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWB40_RS03910	COG0126	phosphoglycerate kinase activity
DWB40_RS03920	COG0469	pyruvate kinase activity
DWB40_RS03925	COG3588	fructose-bisphosphate aldolase
DWB40_RS03935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DWB40_RS03960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB40_RS03965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB40_RS03975	COG1115	amino acid carrier protein
DWB40_RS03980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB40_RS03990	COG1970	mechanosensitive ion channel activity
DWB40_RS04010	COG3273	potassium ion transport
DWB40_RS04010	COG0471	metal ion transport
DWB40_RS04015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWB40_RS04020	COG2022	thiamine diphosphate biosynthetic process
DWB40_RS04030	COG4625	pathogenesis
DWB40_RS04030	COG3240	lipase activity
DWB40_RS04055	COG0189	ligase activity
DWB40_RS04070	COG0745	RESPONSE REGULATOR receiver
DWB40_RS04090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DWB40_RS04125	COG0045	succinate-CoA ligase (ADP-forming) activity
DWB40_RS04135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWB40_RS04135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DWB40_RS04145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWB40_RS04150	COG0564	pseudouridine synthase activity
DWB40_RS04165	COG3011	Protein conserved in bacteria
DWB40_RS04170	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DWB40_RS04175	COG3387	PFAM Glycoside hydrolase 15-related
DWB40_RS04200	COG0028	Belongs to the TPP enzyme family
DWB40_RS04220	COG0542	response to heat
DWB40_RS04230	COG2205	protein histidine kinase activity
DWB40_RS04235	COG0745	RESPONSE REGULATOR receiver
DWB40_RS04245	COG4651	solute:proton antiporter activity
DWB40_RS04245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DWB40_RS04255	COG0488	(ABC) transporter
DWB40_RS04285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DWB40_RS04305	COG0217	transcriptional regulatory protein
DWB40_RS04310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DWB40_RS04315	COG0632	four-way junction helicase activity
DWB40_RS04325	COG2255	four-way junction helicase activity
DWB40_RS04330	COG0824	Thioesterase
DWB40_RS04335	COG0811	peptide transport
DWB40_RS04350	COG0823	Involved in the tonB-independent uptake of proteins
DWB40_RS04355	COG2885	chlorophyll binding
DWB40_RS04365	COG0602	queuosine metabolic process
DWB40_RS04370	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DWB40_RS04545	COG3179	chitinase
DWB40_RS04590	COG4695	Portal protein
DWB40_RS04600	COG3646	Phage regulatory protein
DWB40_RS04610	COG2135	peptidase activity
DWB40_RS04670	COG0514	ATP-dependent DNA helicase (RecQ)
DWB40_RS04675	COG0783	Belongs to the Dps family
DWB40_RS04680	COG1643	Atp-dependent helicase
DWB40_RS04690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWB40_RS04705	COG1215	transferase activity, transferring glycosyl groups
DWB40_RS04710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB40_RS04725	COG1199	ATP-dependent helicase activity
DWB40_RS04730	COG1214	PFAM Peptidase M22, glycoprotease
DWB40_RS04740	COG0189	ligase activity
DWB40_RS04755	COG0835	chemotaxis
DWB40_RS04760	COG0840	transmembrane signaling receptor activity
DWB40_RS04765	COG0643	Histidine kinase
DWB40_RS04765	COG0784	Response regulator, receiver
DWB40_RS04765	COG2198	Histidine kinase
DWB40_RS04780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DWB40_RS04790	COG0494	nUDIX hydrolase
DWB40_RS04800	COG3956	TIGRFAM MazG family protein
DWB40_RS04805	COG1742	UPF0060 membrane protein
DWB40_RS04815	COG0330	HflC and HflK could
DWB40_RS04825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWB40_RS04830	COG0509	glycine decarboxylation via glycine cleavage system
DWB40_RS04840	COG0583	DNA-binding transcription factor activity
DWB40_RS04870	COG1960	acyl-CoA dehydrogenase activity
DWB40_RS04880	COG1309	transcriptional regulator
DWB40_RS04885	COG4206	TonB-dependent receptor
DWB40_RS04895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DWB40_RS04900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB40_RS04905	COG0463	Glycosyl transferase, family 2
DWB40_RS04920	COG1272	protein, Hemolysin III
DWB40_RS04925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DWB40_RS04930	COG0739	heme binding
DWB40_RS04935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB40_RS04940	COG0626	cystathionine gamma-synthase activity
DWB40_RS04945	COG0527	aspartate kinase activity
DWB40_RS04945	COG0460	homoserine dehydrogenase
DWB40_RS04950	COG0596	Alpha beta hydrolase
DWB40_RS04955	COG1760	l-serine dehydratase
DWB40_RS04970	COG3038	cytochrome b561
DWB40_RS04990	COG0477	Major facilitator Superfamily
DWB40_RS05010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DWB40_RS05025	COG0259	pyridoxamine-phosphate oxidase activity
DWB40_RS05040	COG3829	transcription factor binding
DWB40_RS05060	COG3609	addiction module antidote protein, CC2985 family
DWB40_RS05070	COG2828	Protein conserved in bacteria
DWB40_RS05075	COG2079	MmgE PrpD family protein
DWB40_RS05080	COG2373	Large extracellular alpha-helical protein
DWB40_RS05085	COG4953	penicillin-binding protein 1C
DWB40_RS05095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DWB40_RS05095	COG0678	peroxiredoxin activity
DWB40_RS05110	COG0604	alcohol dehydrogenase
DWB40_RS05115	COG0330	HflC and HflK could
DWB40_RS05120	COG0330	HflC and HflK could
DWB40_RS05130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DWB40_RS05140	COG0739	heme binding
DWB40_RS05145	COG1376	ErfK ybiS ycfS ynhG family protein
DWB40_RS05175	COG0753	catalase activity
DWB40_RS05180	COG1917	Cupin 2, conserved barrel domain protein
DWB40_RS05180	COG2207	Transcriptional regulator
DWB40_RS05185	COG1113	amino acid transport
DWB40_RS05195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB40_RS05195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB40_RS05200	COG2814	Major facilitator Superfamily
DWB40_RS05240	COG2205	protein histidine kinase activity
DWB40_RS05255	COG2879	small protein
DWB40_RS05260	COG1966	Carbon starvation protein
DWB40_RS05265	COG1741	Belongs to the pirin family
DWB40_RS05275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWB40_RS05280	COG1741	Belongs to the pirin family
DWB40_RS05300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB40_RS05305	COG0481	GTPase activity
DWB40_RS05310	COG0681	Belongs to the peptidase S26 family
DWB40_RS05325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DWB40_RS05330	COG1381	Involved in DNA repair and RecF pathway recombination
DWB40_RS05335	COG0745	RESPONSE REGULATOR receiver
DWB40_RS05340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWB40_RS05345	COG2954	triphosphatase activity
DWB40_RS05350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DWB40_RS05355	COG1472	Belongs to the glycosyl hydrolase 3 family
DWB40_RS05360	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DWB40_RS05365	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DWB40_RS05370	COG1278	Cold shock
DWB40_RS05375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB40_RS05390	COG1201	RNA secondary structure unwinding
DWB40_RS05395	COG1793	dna ligase
DWB40_RS05405	COG1960	acyl-CoA dehydrogenase activity
DWB40_RS05420	COG0183	Belongs to the thiolase family
DWB40_RS05440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWB40_RS05450	COG1451	nucleotide metabolic process
DWB40_RS05455	COG3122	Protein conserved in bacteria
DWB40_RS05460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DWB40_RS05505	COG0443	Heat shock 70 kDa protein
DWB40_RS05510	COG2824	Alkylphosphonate utilization operon protein PhnA
DWB40_RS05540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DWB40_RS05540	COG0392	lysyltransferase activity
DWB40_RS05545	COG0251	oxidation-reduction process
DWB40_RS05550	COG2878	Part of a membrane complex involved in electron transport
DWB40_RS05560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB40_RS05560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB40_RS05570	COG0346	lactoylglutathione lyase activity
DWB40_RS05575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB40_RS05585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DWB40_RS05610	COG5001	Diguanylate cyclase
DWB40_RS05610	COG4251	negative regulation of phosphorylation
DWB40_RS05610	COG3706	GGDEF domain
DWB40_RS05610	COG2203	Gaf domain
DWB40_RS05620	COG3118	belongs to the thioredoxin family
DWB40_RS05630	COG0495	leucyl-tRNA aminoacylation
DWB40_RS05645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DWB40_RS05655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DWB40_RS05670	COG4771	TonB-dependent receptor
DWB40_RS05680	COG2968	Membrane
DWB40_RS05700	COG0312	modulator of DNA gyrase
DWB40_RS05705	COG3028	Belongs to the UPF0307 family
DWB40_RS05710	COG0312	modulator of DNA gyrase
DWB40_RS05720	COG0142	geranyltranstransferase activity
DWB40_RS05725	COG1722	exodeoxyribonuclease VII activity
DWB40_RS05745	COG1301	dicarboxylic acid transport
DWB40_RS05750	COG0791	NLP P60 protein
DWB40_RS05755	COG0791	NLP P60 protein
DWB40_RS05760	COG1047	Peptidyl-prolyl cis-trans
DWB40_RS05765	COG2311	Membrane
DWB40_RS05770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB40_RS05815	COG3590	peptidase
DWB40_RS05825	COG4771	TonB-dependent receptor
DWB40_RS05830	COG4771	TonB-dependent receptor
DWB40_RS05835	COG0489	protein tyrosine kinase activity
DWB40_RS05840	COG0717	Belongs to the dCTP deaminase family
DWB40_RS05855	COG0412	Dienelactone hydrolase
DWB40_RS05860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB40_RS05870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWB40_RS05875	COG0433	COG0433 Predicted ATPase
DWB40_RS05890	COG0688	phosphatidylethanolamine metabolic process
DWB40_RS05895	COG1999	signal sequence binding
DWB40_RS05900	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB40_RS05905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DWB40_RS05915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DWB40_RS05930	COG0101	tRNA pseudouridine synthase activity
DWB40_RS05935	COG0135	phosphoribosylanthranilate isomerase activity
DWB40_RS05955	COG0133	tryptophan synthase activity
DWB40_RS05965	COG0159	tryptophan synthase activity
DWB40_RS05970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DWB40_RS05975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB40_RS05980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DWB40_RS05985	COG0726	polysaccharide deacetylase
DWB40_RS05990	COG0438	transferase activity, transferring glycosyl groups
DWB40_RS05995	COG3083	sulfuric ester hydrolase activity
DWB40_RS06005	COG0149	triose-phosphate isomerase activity
DWB40_RS06020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB40_RS06025	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB40_RS06030	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB40_RS06035	COG0649	NAD binding
DWB40_RS06040	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DWB40_RS06055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DWB40_RS06060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB40_RS06070	COG0713	ATP synthesis coupled electron transport
DWB40_RS06085	COG1007	ATP synthesis coupled electron transport
DWB40_RS06100	COG0779	Required for maturation of 30S ribosomal subunits
DWB40_RS06105	COG0195	Participates in both transcription termination and antitermination
DWB40_RS06110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DWB40_RS06115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWB40_RS06125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DWB40_RS06130	COG1185	polyribonucleotide nucleotidyltransferase activity
DWB40_RS06165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWB40_RS06170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DWB40_RS06175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DWB40_RS06180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DWB40_RS06185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DWB40_RS06190	COG0072	phenylalanine-tRNA ligase activity
DWB40_RS06190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB40_RS06195	COG0776	regulation of translation
DWB40_RS06235	COG1280	lysine exporter protein (LysE YggA)
DWB40_RS06240	COG5487	UPF0391 membrane protein
DWB40_RS06245	COG2076	Multidrug Resistance protein
DWB40_RS06280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DWB40_RS06290	COG1960	acyl-CoA dehydrogenase activity
DWB40_RS06315	COG2130	NADP-dependent
DWB40_RS06320	COG2169	Transcriptional regulator
DWB40_RS06320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DWB40_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS06360	COG1309	transcriptional regulator
DWB40_RS06365	COG4771	TonB-dependent receptor
DWB40_RS06385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DWB40_RS06395	COG1570	exodeoxyribonuclease VII activity
DWB40_RS06400	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB40_RS06405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DWB40_RS06405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DWB40_RS06410	COG0802	atpase or kinase
DWB40_RS06415	COG0860	N-Acetylmuramoyl-L-alanine amidase
DWB40_RS06420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DWB40_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS06450	COG0501	Belongs to the peptidase M48B family
DWB40_RS06475	COG3300	MHYT domain
DWB40_RS06475	COG5001	Diguanylate cyclase
DWB40_RS06480	COG1509	lysine 2,3-aminomutase activity
DWB40_RS06485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWB40_RS06490	COG0402	S-adenosylhomocysteine deaminase activity
DWB40_RS06495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DWB40_RS06515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWB40_RS06535	COG2166	iron-sulfur cluster assembly
DWB40_RS06550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DWB40_RS06555	COG0137	argininosuccinate synthase activity
DWB40_RS06560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB40_RS06565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DWB40_RS06575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DWB40_RS06580	COG0165	Argininosuccinate lyase
DWB40_RS06595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DWB40_RS06605	COG1215	transferase activity, transferring glycosyl groups
DWB40_RS06610	COG0726	polysaccharide deacetylase
DWB40_RS06610	COG1649	PFAM Uncharacterised BCR, COG1649
DWB40_RS06640	COG1294	oxidase, subunit
DWB40_RS06650	COG4988	ABC transporter
DWB40_RS06655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DWB40_RS06665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB40_RS06675	COG3088	subunit of a heme lyase
DWB40_RS06675	COG4235	cytochrome complex assembly
DWB40_RS06690	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DWB40_RS06710	COG4133	protoheme IX ABC transporter activity
DWB40_RS06715	COG0436	Aminotransferase
DWB40_RS06735	COG2814	Major facilitator Superfamily
DWB40_RS06745	COG1187	pseudouridine synthase activity
DWB40_RS06750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DWB40_RS06755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DWB40_RS06760	COG2350	Protein conserved in bacteria
DWB40_RS06765	COG0271	Belongs to the BolA IbaG family
DWB40_RS06795	COG0395	ABC-type sugar transport system, permease component
DWB40_RS06810	COG1530	ribonuclease E activity
DWB40_RS06820	COG0428	transporter
DWB40_RS06830	COG2154	pterin-4-alpha-carbinolamine dehydratase
DWB40_RS06835	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DWB40_RS06835	COG0316	Belongs to the HesB IscA family
DWB40_RS06850	COG4290	ribonuclease
DWB40_RS06855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DWB40_RS06865	COG3104	oligopeptide transport
DWB40_RS06870	COG0705	Rhomboid family
DWB40_RS06890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWB40_RS06900	COG0339	signal peptide processing
DWB40_RS06905	COG0386	Belongs to the glutathione peroxidase family
DWB40_RS06920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWB40_RS06930	COG1595	DNA-templated transcription, initiation
DWB40_RS06945	COG0625	glutathione transferase activity
DWB40_RS06980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DWB40_RS06985	COG0084	hydrolase, TatD family'
DWB40_RS07005	COG0625	glutathione transferase activity
DWB40_RS07025	COG0305	Participates in initiation and elongation during chromosome replication
DWB40_RS07035	COG3540	Alkaline phosphatase
DWB40_RS07060	COG0567	Dehydrogenase, E1 component
DWB40_RS07070	COG2850	peptidyl-arginine hydroxylation
DWB40_RS07080	COG0114	fumarate hydratase activity
DWB40_RS07105	COG1131	(ABC) transporter
DWB40_RS07110	COG1725	Transcriptional regulator
DWB40_RS07120	COG0386	Belongs to the glutathione peroxidase family
DWB40_RS07135	COG2900	Belongs to the SlyX family
DWB40_RS07150	COG0646	methionine synthase
DWB40_RS07150	COG1410	methionine synthase
DWB40_RS07160	COG2226	methyltransferase
DWB40_RS07165	COG1960	acyl-CoA dehydrogenase activity
DWB40_RS07180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB40_RS07185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB40_RS07195	COG2902	Dehydrogenase
DWB40_RS07220	COG2925	Exonuclease
DWB40_RS07225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB40_RS07230	COG3844	kynureninase activity
DWB40_RS07240	COG0288	reversible hydration of carbon dioxide
DWB40_RS07260	COG0017	Asparaginyl-tRNA synthetase
DWB40_RS07265	COG0316	Belongs to the HesB IscA family
DWB40_RS07275	COG0360	Binds together with S18 to 16S ribosomal RNA
DWB40_RS07280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWB40_RS07285	COG0359	binds to the 23S rRNA
DWB40_RS07300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB40_RS07305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWB40_RS07315	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DWB40_RS07325	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DWB40_RS07335	COG4993	Dehydrogenase
DWB40_RS07385	COG0583	DNA-binding transcription factor activity
DWB40_RS07390	COG2957	Belongs to the agmatine deiminase family
DWB40_RS07440	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DWB40_RS07455	COG1228	amidohydrolase
DWB40_RS07500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DWB40_RS07505	COG0077	Prephenate dehydratase
DWB40_RS07505	COG1605	Chorismate mutase
DWB40_RS07510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DWB40_RS07525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DWB40_RS07535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWB40_RS07540	COG0583	DNA-binding transcription factor activity
DWB40_RS07565	COG3209	COG3209 Rhs family protein
DWB40_RS07575	COG0210	DNA helicase
DWB40_RS07585	COG0604	alcohol dehydrogenase
DWB40_RS07590	COG1733	regulation of RNA biosynthetic process
DWB40_RS07610	COG4774	siderophore transport
DWB40_RS07625	COG0784	Response regulator, receiver
DWB40_RS07625	COG4191	Histidine kinase
DWB40_RS07660	COG0789	Transcriptional regulator
DWB40_RS07665	COG2814	Major facilitator Superfamily
DWB40_RS07680	COG3505	Type IV secretory pathway VirD4
DWB40_RS07690	COG3736	Type IV secretory pathway, component VirB8
DWB40_RS07700	COG2948	multi-organism process
DWB40_RS07720	COG3702	type iv secretory pathway
DWB40_RS07785	COG0456	acetyltransferase
DWB40_RS07790	COG2249	NAD(P)H dehydrogenase (quinone) activity
DWB40_RS07795	COG1733	regulation of RNA biosynthetic process
DWB40_RS07805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DWB40_RS07815	COG1902	pentaerythritol trinitrate reductase activity
DWB40_RS07820	COG0668	transmembrane transport
DWB40_RS07830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB40_RS07850	COG0534	Mate efflux family protein
DWB40_RS07855	COG2226	methyltransferase
DWB40_RS07855	COG1073	alpha beta
DWB40_RS07870	COG3243	poly(R)-hydroxyalkanoic acid synthase
DWB40_RS07880	COG1983	PspC domain protein
DWB40_RS07895	COG2183	response to ionizing radiation
DWB40_RS07900	COG3447	MASE1 domain protein
DWB40_RS07900	COG5001	Diguanylate cyclase
DWB40_RS07900	COG5002	protein histidine kinase activity
DWB40_RS07985	COG0789	Transcriptional regulator
DWB40_RS07995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB40_RS08010	COG0531	amino acid
DWB40_RS08040	COG1629	transport
DWB40_RS08040	COG4206	TonB-dependent receptor
DWB40_RS08050	COG1595	DNA-templated transcription, initiation
DWB40_RS08065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWB40_RS08065	COG0519	Catalyzes the synthesis of GMP from XMP
DWB40_RS08070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWB40_RS08085	COG0587	DNA-directed DNA polymerase activity
DWB40_RS08140	COG2814	Major facilitator Superfamily
DWB40_RS08170	COG1285	pathogenesis
DWB40_RS08180	COG2186	Transcriptional regulator
DWB40_RS08185	COG1304	FMN binding
DWB40_RS08190	COG0277	FAD linked oxidase domain protein
DWB40_RS08230	COG3161	chorismate lyase activity
DWB40_RS08245	COG0583	DNA-binding transcription factor activity
DWB40_RS08255	COG1228	amidohydrolase
DWB40_RS08265	COG2814	Major facilitator Superfamily
DWB40_RS08270	COG2197	response regulator
DWB40_RS08275	COG3850	Histidine kinase
DWB40_RS08290	COG1335	isochorismatase
DWB40_RS08300	COG1228	amidohydrolase
DWB40_RS08310	COG2814	Major facilitator Superfamily
DWB40_RS08365	COG4964	Belongs to the GSP D family
DWB40_RS08410	COG2226	methyltransferase
DWB40_RS08430	COG4772	TonB-dependent receptor
DWB40_RS08475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB40_RS08480	COG4206	TonB-dependent receptor
DWB40_RS08485	COG0604	alcohol dehydrogenase
DWB40_RS08485	COG3321	synthase
DWB40_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS08490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB40_RS08495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB40_RS08510	COG1914	H( )-stimulated, divalent metal cation uptake system
DWB40_RS08580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB40_RS08585	COG2409	Drug exporters of the RND superfamily
DWB40_RS08595	COG1169	isochorismate synthase
DWB40_RS08600	COG1021	2,3-dihydroxybenzoate-AMP ligase
DWB40_RS08605	COG3433	isochorismatase activity
DWB40_RS08605	COG1535	isochorismatase
DWB40_RS08615	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DWB40_RS08615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB40_RS08620	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS08655	COG2194	sulfuric ester hydrolase activity
DWB40_RS08665	COG2205	protein histidine kinase activity
DWB40_RS08690	COG1566	PFAM secretion protein HlyD family protein
DWB40_RS08705	COG2207	Transcriptional regulator
DWB40_RS08740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWB40_RS08745	COG0315	cyclic pyranopterin monophosphate synthase activity
DWB40_RS08745	COG0521	Mo-molybdopterin cofactor biosynthetic process
DWB40_RS08750	COG0303	'Molybdopterin
DWB40_RS08760	COG0314	molybdopterin synthase activity
DWB40_RS08765	COG0746	molybdenum cofactor guanylyltransferase activity
DWB40_RS08775	COG2223	nitrite transmembrane transporter activity
DWB40_RS08780	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DWB40_RS08785	COG1140	nitrate reductase beta subunit
DWB40_RS08790	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DWB40_RS08795	COG2181	nitrate reductase activity
DWB40_RS08800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DWB40_RS08815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB40_RS08820	COG0725	ABC transporter, periplasmic molybdate-binding protein
DWB40_RS08825	COG4149	molybdate abc transporter
DWB40_RS08830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DWB40_RS08835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DWB40_RS08840	COG0840	transmembrane signaling receptor activity
DWB40_RS08850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DWB40_RS08855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DWB40_RS08900	COG1595	DNA-templated transcription, initiation
DWB40_RS08995	COG0811	peptide transport
DWB40_RS09025	COG1335	isochorismatase
DWB40_RS09030	COG1335	isochorismatase
DWB40_RS09075	COG2202	Pas domain
DWB40_RS09075	COG3920	Histidine kinase
DWB40_RS09095	COG0477	Major facilitator Superfamily
DWB40_RS09110	COG3537	Alpha-1,2-mannosidase
DWB40_RS09115	COG0642	Histidine kinase
DWB40_RS09140	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS09145	COG0583	DNA-binding transcription factor activity
DWB40_RS09150	COG5002	protein histidine kinase activity
DWB40_RS09165	COG2372	response to copper ion
DWB40_RS09185	COG0656	L-ascorbic acid biosynthetic process
DWB40_RS09190	COG0583	DNA-binding transcription factor activity
DWB40_RS09205	COG1136	(ABC) transporter
DWB40_RS09230	COG0477	Major facilitator Superfamily
DWB40_RS09255	COG0243	molybdopterin cofactor binding
DWB40_RS09310	COG4566	intracellular signal transduction
DWB40_RS09315	COG4191	Histidine kinase
DWB40_RS09320	COG1285	pathogenesis
DWB40_RS09325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DWB40_RS09345	COG4774	siderophore transport
DWB40_RS09355	COG3214	Protein conserved in bacteria
DWB40_RS09365	COG2205	protein histidine kinase activity
DWB40_RS09370	COG0745	RESPONSE REGULATOR receiver
DWB40_RS09380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB40_RS09385	COG1136	(ABC) transporter
DWB40_RS09385	COG0577	efflux transmembrane transporter activity
DWB40_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS09405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB40_RS09410	COG0366	Alpha amylase catalytic
DWB40_RS09415	COG0708	Exodeoxyribonuclease III
DWB40_RS09425	COG0515	serine threonine protein kinase
DWB40_RS09505	COG2204	response regulator
DWB40_RS09530	COG0583	DNA-binding transcription factor activity
DWB40_RS09550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWB40_RS09575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB40_RS09585	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS09590	COG2271	Major facilitator Superfamily
DWB40_RS09610	COG2186	Transcriptional regulator
DWB40_RS09625	COG0318	PFAM AMP-dependent synthetase and ligase
DWB40_RS09635	COG0642	Histidine kinase
DWB40_RS09660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB40_RS09690	COG0583	DNA-binding transcription factor activity
DWB40_RS09695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DWB40_RS09720	COG0583	DNA-binding transcription factor activity
DWB40_RS09725	COG2828	Protein conserved in bacteria
DWB40_RS09740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWB40_RS09755	COG1472	Belongs to the glycosyl hydrolase 3 family
DWB40_RS09760	COG1609	Transcriptional regulator
DWB40_RS09765	COG0738	Major facilitator superfamily
DWB40_RS09770	COG4771	TonB-dependent receptor
DWB40_RS09785	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DWB40_RS09790	COG1733	regulation of RNA biosynthetic process
DWB40_RS09810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB40_RS09810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB40_RS09815	COG1105	Belongs to the carbohydrate kinase PfkB family
DWB40_RS09820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB40_RS09820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB40_RS09825	COG1609	Transcriptional regulator
DWB40_RS09855	COG1063	alcohol dehydrogenase
DWB40_RS09875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWB40_RS09905	COG3546	catalase activity
DWB40_RS09930	COG3685	Protein conserved in bacteria
DWB40_RS10000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB40_RS10005	COG1595	DNA-templated transcription, initiation
DWB40_RS10025	COG0583	DNA-binding transcription factor activity
DWB40_RS10035	COG1764	response to oxidative stress
DWB40_RS10045	COG2080	2 iron, 2 sulfur cluster binding
DWB40_RS10050	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DWB40_RS10055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DWB40_RS10060	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DWB40_RS10130	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DWB40_RS10140	COG4251	negative regulation of phosphorylation
DWB40_RS10145	COG0784	Response regulator, receiver
DWB40_RS10165	COG1595	DNA-templated transcription, initiation
DWB40_RS10180	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DWB40_RS10190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWB40_RS10205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWB40_RS10220	COG0784	Response regulator, receiver
DWB40_RS10220	COG5002	protein histidine kinase activity
DWB40_RS10235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWB40_RS10245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DWB40_RS10250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB40_RS10255	COG4558	Periplasmic binding protein
DWB40_RS10265	COG2819	hydrolase of the alpha beta superfamily
DWB40_RS10280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DWB40_RS10300	COG1674	ftsk spoiiie
DWB40_RS10305	COG0492	ferredoxin-NADP+ reductase activity
DWB40_RS10335	COG0542	response to heat
DWB40_RS10345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DWB40_RS10360	COG0482	sulfurtransferase activity
DWB40_RS10365	COG2915	High frequency lysogenization protein hflD homolog
DWB40_RS10400	COG5002	protein histidine kinase activity
DWB40_RS10420	COG0784	Response regulator, receiver
DWB40_RS10420	COG0835	chemotaxis
DWB40_RS10425	COG1815	bacterial-type flagellum-dependent cell motility
DWB40_RS10430	COG1558	bacterial-type flagellum-dependent cell motility
DWB40_RS10445	COG4787	bacterial-type flagellum-dependent cell motility
DWB40_RS10455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DWB40_RS10485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DWB40_RS10495	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DWB40_RS10515	COG2197	response regulator
DWB40_RS10545	COG1677	Flagellar hook-basal body complex protein FliE
DWB40_RS10595	COG3190	flagellar
DWB40_RS10605	COG1987	bacterial-type flagellum assembly
DWB40_RS10625	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DWB40_RS10630	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DWB40_RS10655	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DWB40_RS10660	COG0643	Histidine kinase
DWB40_RS10660	COG0784	Response regulator, receiver
DWB40_RS10660	COG2198	Histidine kinase
DWB40_RS10665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DWB40_RS10670	COG1360	Flagellar Motor Protein
DWB40_RS10680	COG0835	chemotaxis
DWB40_RS10690	COG0745	RESPONSE REGULATOR receiver
DWB40_RS10700	COG0840	transmembrane signaling receptor activity
DWB40_RS10705	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DWB40_RS10710	COG0835	chemotaxis
DWB40_RS10720	COG0840	transmembrane signaling receptor activity
DWB40_RS10725	COG0840	transmembrane signaling receptor activity
DWB40_RS10735	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DWB40_RS10780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB40_RS10785	COG1309	transcriptional regulator
DWB40_RS10790	COG1012	belongs to the aldehyde dehydrogenase family
DWB40_RS10795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DWB40_RS10800	COG0318	PFAM AMP-dependent synthetase and ligase
DWB40_RS10805	COG1024	Enoyl-CoA hydratase
DWB40_RS10810	COG2198	Histidine kinase
DWB40_RS10810	COG2205	protein histidine kinase activity
DWB40_RS10810	COG0784	Response regulator, receiver
DWB40_RS10830	COG1012	belongs to the aldehyde dehydrogenase family
DWB40_RS10845	COG3279	Response regulator of the LytR AlgR family
DWB40_RS10860	COG4676	Protein conserved in bacteria
DWB40_RS10865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DWB40_RS10880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWB40_RS10885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DWB40_RS10890	COG0505	Belongs to the CarA family
DWB40_RS10895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DWB40_RS10910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWB40_RS10955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWB40_RS10970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB40_RS10975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB40_RS10980	COG0745	RESPONSE REGULATOR receiver
DWB40_RS10985	COG2205	protein histidine kinase activity
DWB40_RS11000	COG0277	FAD linked oxidase domain protein
DWB40_RS11005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWB40_RS11015	COG0531	amino acid
DWB40_RS11020	COG0531	amino acid
DWB40_RS11035	COG0235	Class ii aldolase
DWB40_RS11040	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DWB40_RS11045	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
DWB40_RS11060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB40_RS11070	COG1609	Transcriptional regulator
DWB40_RS11075	COG3537	Alpha-1,2-mannosidase
DWB40_RS11090	COG0789	Transcriptional regulator
DWB40_RS11095	COG2217	Heavy metal translocating P-type atpase
DWB40_RS11105	COG3142	Participates in the control of copper homeostasis
DWB40_RS11110	COG1446	asparaginase
DWB40_RS11115	COG0837	glucose binding
DWB40_RS11130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DWB40_RS11130	COG0140	phosphoribosyl-ATP diphosphatase activity
DWB40_RS11135	COG0107	imidazoleglycerol-phosphate synthase activity
DWB40_RS11140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DWB40_RS11145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DWB40_RS11150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DWB40_RS11150	COG0131	Imidazoleglycerol-phosphate dehydratase
DWB40_RS11155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB40_RS11160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DWB40_RS11165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DWB40_RS11175	COG0124	histidyl-tRNA synthetase
DWB40_RS11180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB40_RS11185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DWB40_RS11195	COG0460	homoserine dehydrogenase
DWB40_RS11195	COG0527	aspartate kinase activity
DWB40_RS11235	COG0640	Transcriptional regulator
DWB40_RS11240	COG0745	RESPONSE REGULATOR receiver
DWB40_RS11250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DWB40_RS11255	COG4999	Histidine kinase
DWB40_RS11255	COG3437	response regulator, receiver
DWB40_RS11255	COG2205	protein histidine kinase activity
DWB40_RS11255	COG3850	Histidine kinase
DWB40_RS11260	COG0784	Response regulator, receiver
DWB40_RS11260	COG4191	Histidine kinase
DWB40_RS11390	COG1012	belongs to the aldehyde dehydrogenase family
DWB40_RS11395	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS11410	COG0167	dihydroorotate dehydrogenase activity
DWB40_RS11415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWB40_RS11420	COG0697	spore germination
DWB40_RS11425	COG3415	Transposase
DWB40_RS11425	COG2801	Transposase and inactivated derivatives
DWB40_RS11440	COG1309	transcriptional regulator
DWB40_RS11460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB40_RS11470	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS11475	COG0477	Major facilitator Superfamily
DWB40_RS11480	COG0583	DNA-binding transcription factor activity
DWB40_RS11485	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DWB40_RS11510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB40_RS11515	COG1126	abc transporter atp-binding protein
DWB40_RS11530	COG1473	amidohydrolase
DWB40_RS11535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB40_RS11540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB40_RS11550	COG0431	NADPH-dependent FMN reductase
DWB40_RS11585	COG4716	Myosin-crossreactive antigen
DWB40_RS11600	COG0640	Transcriptional regulator
DWB40_RS11625	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS11645	COG0583	DNA-binding transcription factor activity
DWB40_RS11670	COG0519	Catalyzes the synthesis of GMP from XMP
DWB40_RS11670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWB40_RS11685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DWB40_RS11685	COG0475	glutathione-regulated potassium exporter activity
DWB40_RS11690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DWB40_RS11710	COG1160	GTP binding
DWB40_RS11715	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWB40_RS11725	COG1426	Protein conserved in bacteria
DWB40_RS11725	COG1426	Protein conserved in bacteria
DWB40_RS11730	COG0859	PFAM glycosyl transferase family 9
DWB40_RS11730	COG0457	Tetratricopeptide repeat
DWB40_RS11735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DWB40_RS11740	COG0105	UTP biosynthetic process
DWB40_RS11750	COG1024	Enoyl-CoA hydratase
DWB40_RS11750	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWB40_RS11755	COG0183	Belongs to the thiolase family
DWB40_RS11760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWB40_RS11770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWB40_RS11775	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DWB40_RS11785	COG0776	regulation of translation
DWB40_RS11795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DWB40_RS11800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DWB40_RS11810	COG2957	Belongs to the agmatine deiminase family
DWB40_RS11815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DWB40_RS11830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB40_RS11855	COG0488	(ABC) transporter
DWB40_RS11860	COG0583	DNA-binding transcription factor activity
DWB40_RS11870	COG0513	Belongs to the DEAD box helicase family
DWB40_RS11875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB40_RS11880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DWB40_RS11885	COG0625	glutathione transferase activity
DWB40_RS11900	COG0564	pseudouridine synthase activity
DWB40_RS11905	COG4681	YaeQ
DWB40_RS11910	COG2081	HI0933 family
DWB40_RS11920	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DWB40_RS11925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB40_RS11935	COG1862	Preprotein translocase
DWB40_RS11940	COG0343	queuine tRNA-ribosyltransferase activity
DWB40_RS11950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DWB40_RS11955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB40_RS11985	COG1132	(ABC) transporter
DWB40_RS11995	COG0287	Prephenate dehydrogenase
DWB40_RS11995	COG1605	Chorismate mutase
DWB40_RS12000	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DWB40_RS12005	COG2223	nitrite transmembrane transporter activity
DWB40_RS12010	COG2207	Transcriptional regulator
DWB40_RS12015	COG0484	heat shock protein binding
DWB40_RS12020	COG0443	Heat shock 70 kDa protein
DWB40_RS12025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWB40_RS12030	COG1420	regulation of RNA biosynthetic process
DWB40_RS12035	COG0497	DNA recombination
DWB40_RS12040	COG0583	DNA-binding transcription factor activity
DWB40_RS12050	COG0735	belongs to the Fur family
DWB40_RS12055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWB40_RS12060	COG2914	Belongs to the UPF0125 (RnfH) family
DWB40_RS12070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DWB40_RS12085	COG0582	viral genome integration into host DNA
DWB40_RS12100	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DWB40_RS12205	COG0740	serine-type endopeptidase activity
DWB40_RS12215	COG4626	Terminase
DWB40_RS12215	COG1802	Transcriptional regulator
DWB40_RS12460	COG0583	DNA-binding transcription factor activity
DWB40_RS12465	COG2885	chlorophyll binding
DWB40_RS12470	COG0415	Belongs to the DNA photolyase family
DWB40_RS12480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DWB40_RS12500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWB40_RS12520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB40_RS12525	COG0405	Gamma-glutamyltransferase
DWB40_RS12530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DWB40_RS12540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWB40_RS12545	COG0742	ribosomal rna small subunit methyltransferase
DWB40_RS12560	COG0552	protein localization to endoplasmic reticulum
DWB40_RS12570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DWB40_RS12585	COG4591	ABC-type transport system involved in lipoprotein release permease component
DWB40_RS12605	COG1053	succinate dehydrogenase
DWB40_RS12610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DWB40_RS12615	COG2009	succinate dehydrogenase
DWB40_RS12640	COG0837	glucose binding
DWB40_RS12650	COG0129	dihydroxy-acid dehydratase activity
DWB40_RS12655	COG0800	Aldolase
DWB40_RS12665	COG0671	phosphoesterase, PA-phosphatase related
DWB40_RS12670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DWB40_RS12680	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DWB40_RS12685	COG0166	Belongs to the GPI family
DWB40_RS12690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DWB40_RS12700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DWB40_RS12705	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DWB40_RS12715	COG0617	tRNA 3'-terminal CCA addition
DWB40_RS12725	COG0477	Major facilitator Superfamily
DWB40_RS12730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DWB40_RS12740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB40_RS12750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DWB40_RS12755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DWB40_RS12770	COG0352	thiamine-phosphate diphosphorylase activity
DWB40_RS12770	COG0351	phosphomethylpyrimidine kinase
DWB40_RS12795	COG0583	DNA-binding transcription factor activity
DWB40_RS12800	COG1741	Belongs to the pirin family
DWB40_RS12815	COG2223	nitrite transmembrane transporter activity
DWB40_RS12830	COG3258	Cytochrome c
DWB40_RS12845	COG3540	Alkaline phosphatase
DWB40_RS12895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DWB40_RS12900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DWB40_RS12905	COG2137	regulation of response to DNA damage stimulus
DWB40_RS12910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWB40_RS12915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWB40_RS12920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DWB40_RS12925	COG1546	Belongs to the CinA family
DWB40_RS12930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWB40_RS12935	COG1923	regulation of RNA biosynthetic process
DWB40_RS12940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DWB40_RS12945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DWB40_RS12955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWB40_RS12960	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DWB40_RS12965	COG1534	Rna-binding protein
DWB40_RS12990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB40_RS12995	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DWB40_RS13000	COG2840	Smr protein MutS2
DWB40_RS13010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DWB40_RS13015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DWB40_RS13020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DWB40_RS13025	COG0148	phosphopyruvate hydratase activity
DWB40_RS13040	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DWB40_RS13045	COG0504	CTP synthase activity
DWB40_RS13060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB40_RS13080	COG1253	flavin adenine dinucleotide binding
DWB40_RS13095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB40_RS13100	COG1054	Belongs to the UPF0176 family
DWB40_RS13125	COG0069	glutamate synthase activity
DWB40_RS13130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DWB40_RS13145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DWB40_RS13160	COG0348	domain, Protein
DWB40_RS13180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB40_RS13185	COG1917	Cupin 2, conserved barrel domain protein
DWB40_RS13185	COG4977	sequence-specific DNA binding
DWB40_RS13205	COG0583	DNA-binding transcription factor activity
DWB40_RS13230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DWB40_RS13300	COG0577	efflux transmembrane transporter activity
DWB40_RS13300	COG1136	(ABC) transporter
DWB40_RS13335	COG0322	excinuclease ABC activity
DWB40_RS13345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB40_RS13350	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DWB40_RS13355	COG1663	tetraacyldisaccharide 4'-kinase activity
DWB40_RS13370	COG0811	peptide transport
DWB40_RS13390	COG3713	MltA-interacting MipA family protein
DWB40_RS13430	COG0556	nucleotide-excision repair
DWB40_RS13435	COG4970	Tfp pilus assembly protein FimT
DWB40_RS13475	COG1611	Belongs to the LOG family
DWB40_RS13490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DWB40_RS13500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWB40_RS13535	COG2969	positive regulation of protein catabolic process
DWB40_RS13540	COG0625	glutathione transferase activity
DWB40_RS13545	COG2857	Cytochrome c1
DWB40_RS13550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DWB40_RS13555	COG0723	plastoquinol--plastocyanin reductase activity
DWB40_RS13560	COG0741	lytic transglycosylase activity
DWB40_RS13575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB40_RS13580	COG0842	Transport permease protein
DWB40_RS13585	COG1131	(ABC) transporter
DWB40_RS13595	COG1702	phosphate starvation-inducible protein PhoH
DWB40_RS13600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DWB40_RS13620	COG4535	Mg2 and Co2 transporter CorC
DWB40_RS13635	COG1012	belongs to the aldehyde dehydrogenase family
DWB40_RS13640	COG1177	transmembrane transport
DWB40_RS13645	COG1176	ABC-type spermidine putrescine transport system, permease component I
DWB40_RS13650	COG3842	ATPase activity
DWB40_RS13655	COG2072	flavoprotein involved in K transport
DWB40_RS13665	COG0174	glutamine synthetase
DWB40_RS13670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DWB40_RS13675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB40_RS13695	COG2703	oxygen carrier activity
DWB40_RS13700	COG0477	Major facilitator Superfamily
DWB40_RS13710	COG1012	belongs to the aldehyde dehydrogenase family
DWB40_RS13715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DWB40_RS13725	COG2733	membrane
DWB40_RS13745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DWB40_RS13745	COG0116	Belongs to the methyltransferase superfamily
DWB40_RS13765	COG0494	nUDIX hydrolase
DWB40_RS13775	COG1024	Enoyl-CoA hydratase
DWB40_RS13785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWB40_RS13795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DWB40_RS13800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DWB40_RS13805	COG0573	inorganic phosphate transmembrane transporter activity
DWB40_RS13810	COG0581	inorganic phosphate transmembrane transporter activity
DWB40_RS13820	COG0704	Plays a role in the regulation of phosphate uptake
DWB40_RS13830	COG3220	belongs to the UPF0276 family
DWB40_RS13840	COG2259	Doxx family
DWB40_RS13845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DWB40_RS13865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB40_RS13870	COG1136	(ABC) transporter
DWB40_RS13870	COG0577	efflux transmembrane transporter activity
DWB40_RS13875	COG1538	Outer membrane efflux protein
DWB40_RS13885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB40_RS13895	COG0557	exoribonuclease II activity
DWB40_RS13915	COG0583	DNA-binding transcription factor activity
DWB40_RS13930	COG2814	Major facilitator Superfamily
DWB40_RS13935	COG1566	PFAM secretion protein HlyD family protein
DWB40_RS13970	COG0475	glutathione-regulated potassium exporter activity
DWB40_RS13975	COG0367	asparagine synthase
DWB40_RS13980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB40_RS13985	COG1393	Belongs to the ArsC family
DWB40_RS13995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DWB40_RS14015	COG3188	usher protein
DWB40_RS14030	COG0052	Belongs to the universal ribosomal protein uS2 family
DWB40_RS14035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWB40_RS14045	COG0528	UMP kinase activity
DWB40_RS14050	COG0233	cytoplasmic translational termination
DWB40_RS14055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWB40_RS14060	COG0575	Belongs to the CDS family
DWB40_RS14065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DWB40_RS14070	COG0750	zinc metalloprotease
DWB40_RS14075	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWB40_RS14080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DWB40_RS14090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DWB40_RS14115	COG0825	malonyl-CoA metabolic process
DWB40_RS14120	COG1981	membrane
DWB40_RS14140	COG1695	Transcriptional regulator
DWB40_RS14190	COG1132	(ABC) transporter
DWB40_RS14195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB40_RS14215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DWB40_RS14225	COG1187	pseudouridine synthase activity
DWB40_RS14235	COG5002	protein histidine kinase activity
DWB40_RS14235	COG5001	Diguanylate cyclase
DWB40_RS14275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DWB40_RS14315	COG0735	belongs to the Fur family
DWB40_RS14320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DWB40_RS14335	COG4452	Inner membrane protein CreD
DWB40_RS14340	COG2205	protein histidine kinase activity
DWB40_RS14345	COG0745	RESPONSE REGULATOR receiver
DWB40_RS14350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DWB40_RS14360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DWB40_RS14370	COG2801	Transposase and inactivated derivatives
DWB40_RS14370	COG3415	Transposase
DWB40_RS14380	COG3590	peptidase
DWB40_RS14385	COG0588	phosphoglycerate mutase activity
DWB40_RS14410	COG3706	GGDEF domain
DWB40_RS14415	COG2801	Transposase and inactivated derivatives
DWB40_RS14415	COG3415	Transposase
DWB40_RS14420	COG2814	Major facilitator Superfamily
DWB40_RS14445	COG1647	Serine aminopeptidase, S33
DWB40_RS14470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DWB40_RS14495	COG0024	Methionine aminopeptidase
DWB40_RS14515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB40_RS14535	COG0840	transmembrane signaling receptor activity
DWB40_RS14565	COG0753	catalase activity
DWB40_RS14585	COG0534	Mate efflux family protein
DWB40_RS14605	COG0335	large ribosomal subunit rRNA binding
DWB40_RS14610	COG0336	Belongs to the RNA methyltransferase TrmD family
DWB40_RS14615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DWB40_RS14620	COG0228	four-way junction DNA binding
DWB40_RS14635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DWB40_RS14655	COG0326	Molecular chaperone. Has ATPase activity
DWB40_RS14670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DWB40_RS14675	COG1845	cytochrome c oxidase, subunit III
DWB40_RS14680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DWB40_RS14710	COG3209	COG3209 Rhs family protein
DWB40_RS14720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB40_RS14740	COG4206	TonB-dependent receptor
DWB40_RS14765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DWB40_RS14775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DWB40_RS14780	COG0196	riboflavin kinase activity
DWB40_RS14785	COG0728	peptidoglycan biosynthetic process
DWB40_RS14790	COG0268	Binds directly to 16S ribosomal RNA
DWB40_RS14795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DWB40_RS14800	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWB40_RS14805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWB40_RS14810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWB40_RS14815	COG0824	Thioesterase
DWB40_RS14835	COG1946	Acyl-CoA thioesterase
DWB40_RS14845	COG1595	DNA-templated transcription, initiation
DWB40_RS14855	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DWB40_RS14865	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DWB40_RS14905	COG2197	response regulator
DWB40_RS14910	COG4585	Histidine kinase
DWB40_RS14925	COG2894	cell division
DWB40_RS14930	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DWB40_RS14945	COG1506	peptidase
DWB40_RS14945	COG0823	Involved in the tonB-independent uptake of proteins
DWB40_RS14950	COG1297	OPT oligopeptide transporter protein
DWB40_RS14965	COG3104	oligopeptide transport
DWB40_RS14990	COG0579	oxidoreductase
DWB40_RS15005	COG3052	prosthetic group binding
DWB40_RS15040	COG1802	Transcriptional regulator
DWB40_RS15055	COG0477	Major facilitator Superfamily
DWB40_RS15085	COG2259	Doxx family
DWB40_RS15105	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DWB40_RS15110	COG1408	metallophosphoesterase
DWB40_RS15115	COG1253	flavin adenine dinucleotide binding
DWB40_RS15120	COG3655	Transcriptional regulator
DWB40_RS15135	COG0640	Transcriptional regulator
DWB40_RS15175	COG1609	Transcriptional regulator
DWB40_RS15185	COG2211	Major facilitator Superfamily
DWB40_RS15190	COG0673	inositol 2-dehydrogenase activity
DWB40_RS15200	COG2010	Cytochrome c
DWB40_RS15245	COG0629	single-stranded DNA binding
DWB40_RS15255	COG1131	(ABC) transporter
DWB40_RS15290	COG2190	(PTS) system
DWB40_RS15290	COG2211	Major facilitator Superfamily
DWB40_RS15300	COG1082	Xylose isomerase domain protein TIM barrel
DWB40_RS15310	COG0366	Alpha amylase catalytic
DWB40_RS15315	COG0142	geranyltranstransferase activity
DWB40_RS15340	COG0527	aspartate kinase activity
DWB40_RS15345	COG0384	phenazine biosynthesis protein PhzF
DWB40_RS15350	COG0384	phenazine biosynthesis protein PhzF
DWB40_RS15355	COG1764	response to oxidative stress
DWB40_RS15380	COG0693	protein deglycase activity
DWB40_RS15390	COG1959	2 iron, 2 sulfur cluster binding
DWB40_RS15395	COG0719	Fe-S assembly protein
DWB40_RS15405	COG0396	ATPase activity
DWB40_RS15410	COG0719	Fe-S assembly protein
DWB40_RS15415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWB40_RS15430	COG2146	nitrite reductase [NAD(P)H] activity
DWB40_RS15440	COG4774	siderophore transport
DWB40_RS15450	COG3128	pkhd-type hydroxylase
DWB40_RS15460	COG4771	TonB-dependent receptor
DWB40_RS15480	COG1477	protein flavinylation
DWB40_RS15485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DWB40_RS15505	COG1555	photosystem II stabilization
DWB40_RS15515	COG2261	transglycosylase associated protein
DWB40_RS15525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DWB40_RS15535	COG0628	permease
DWB40_RS15545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWB40_RS15565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DWB40_RS15585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB40_RS15600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DWB40_RS15615	COG1137	ATPase activity
DWB40_RS15625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DWB40_RS15630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB40_RS15635	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DWB40_RS15640	COG1660	Displays ATPase and GTPase activities
DWB40_RS15655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB40_RS15660	COG2239	Acts as a magnesium transporter
DWB40_RS15680	COG0540	Belongs to the ATCase OTCase family
DWB40_RS15685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DWB40_RS15690	COG1678	Uncharacterized ACR, COG1678
DWB40_RS15695	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DWB40_RS15700	COG2818	Glycosylase
DWB40_RS15710	COG0456	acetyltransferase
DWB40_RS15725	COG0667	Aldo Keto reductase
DWB40_RS15740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWB40_RS15750	COG0583	DNA-binding transcription factor activity
DWB40_RS15785	COG0477	Major facilitator Superfamily
DWB40_RS15795	COG0697	spore germination
DWB40_RS15800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB40_RS15805	COG0583	DNA-binding transcription factor activity
DWB40_RS15815	COG2226	methyltransferase
DWB40_RS15830	COG2223	nitrite transmembrane transporter activity
DWB40_RS15845	COG4774	siderophore transport
DWB40_RS16010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DWB40_RS16015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DWB40_RS16020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB40_RS16025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB40_RS16035	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS16040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DWB40_RS16050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB40_RS16055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DWB40_RS16060	COG1399	metal-binding, possibly nucleic acid-binding protein
DWB40_RS16075	COG0714	Associated with various cellular activities
DWB40_RS16095	COG0537	adenosine 5'-monophosphoramidase activity
DWB40_RS16105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DWB40_RS16135	COG2076	Multidrug Resistance protein
DWB40_RS16150	COG1234	tRNA 3'-trailer cleavage
DWB40_RS16155	COG3642	lipopolysaccharide core region biosynthetic process
DWB40_RS16160	COG0859	PFAM glycosyl transferase family 9
DWB40_RS16180	COG0631	protein serine/threonine phosphatase activity
DWB40_RS16185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DWB40_RS16190	COG0328	RNA-DNA hybrid ribonuclease activity
DWB40_RS16200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB40_RS16205	COG1388	LysM domain
DWB40_RS16205	COG3942	CHAP domain
DWB40_RS16210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DWB40_RS16250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DWB40_RS16255	COG0740	serine-type endopeptidase activity
DWB40_RS16260	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWB40_RS16325	COG0473	3-isopropylmalate dehydrogenase activity
DWB40_RS16340	COG4783	chaperone-mediated protein folding
DWB40_RS16355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DWB40_RS16360	COG0248	Ppx GppA phosphatase
DWB40_RS16375	COG0438	transferase activity, transferring glycosyl groups
DWB40_RS16385	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DWB40_RS16390	COG3291	Pkd domain containing protein
DWB40_RS16400	COG2833	Protein of unknown function (DUF455)
DWB40_RS16420	COG0285	dihydrofolate synthase activity
DWB40_RS16425	COG0406	alpha-ribazole phosphatase activity
DWB40_RS16435	COG1063	alcohol dehydrogenase
DWB40_RS16455	COG1187	pseudouridine synthase activity
DWB40_RS16470	COG0604	alcohol dehydrogenase
DWB40_RS16475	COG2364	Membrane
DWB40_RS16480	COG1902	pentaerythritol trinitrate reductase activity
DWB40_RS16480	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB40_RS16490	COG0625	glutathione transferase activity
DWB40_RS16505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB40_RS16515	COG0564	pseudouridine synthase activity
DWB40_RS16520	COG0039	L-malate dehydrogenase activity
DWB40_RS16525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DWB40_RS16540	COG0154	amidase activity
DWB40_RS16550	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DWB40_RS16565	COG0203	ribosomal protein L17
DWB40_RS16570	COG0202	RNA polymerase activity
DWB40_RS16575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWB40_RS16580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DWB40_RS16585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DWB40_RS16590	COG0201	protein transport
DWB40_RS16595	COG0200	Binds to the 23S rRNA
DWB40_RS16600	COG1841	ribosomal large subunit assembly
DWB40_RS16605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DWB40_RS16610	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DWB40_RS16615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DWB40_RS16620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DWB40_RS16625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB40_RS16630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DWB40_RS16635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DWB40_RS16640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DWB40_RS16645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DWB40_RS16650	COG0255	Belongs to the universal ribosomal protein uL29 family
DWB40_RS16655	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DWB40_RS16660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DWB40_RS16665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DWB40_RS16670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DWB40_RS16675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DWB40_RS16680	COG0089	rRNA binding
DWB40_RS16685	COG0088	Forms part of the polypeptide exit tunnel
DWB40_RS16690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWB40_RS16695	COG0051	transcription antitermination factor activity, RNA binding
DWB40_RS16700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWB40_RS16705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWB40_RS16710	COG0049	tRNA binding
DWB40_RS16715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWB40_RS16720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DWB40_RS16725	COG0085	RNA polymerase activity
DWB40_RS16730	COG0222	ribosome binding
DWB40_RS16735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DWB40_RS16740	COG0081	regulation of translation
DWB40_RS16745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DWB40_RS16750	COG0250	Participates in transcription elongation, termination and antitermination
DWB40_RS16765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWB40_RS16790	COG4242	Belongs to the peptidase S51 family
DWB40_RS16795	COG4206	TonB-dependent receptor
DWB40_RS16800	COG0784	Response regulator, receiver
DWB40_RS16800	COG2205	protein histidine kinase activity
DWB40_RS16805	COG2199	diguanylate cyclase activity
DWB40_RS16805	COG2200	EAL domain
DWB40_RS16805	COG2203	Gaf domain
DWB40_RS16810	COG0784	Response regulator, receiver
DWB40_RS16810	COG2205	protein histidine kinase activity
DWB40_RS16815	COG2197	response regulator
DWB40_RS16825	COG0012	GTP binding
DWB40_RS16830	COG0193	aminoacyl-tRNA hydrolase activity
DWB40_RS16835	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DWB40_RS16840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DWB40_RS16850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DWB40_RS16865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWB40_RS16870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DWB40_RS16885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB40_RS16890	COG1295	ribonuclease BN
DWB40_RS16910	COG1404	Belongs to the peptidase S8 family
DWB40_RS16915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB40_RS16930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DWB40_RS16955	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DWB40_RS16970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB40_RS16970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB40_RS17010	COG3634	alkyl hydroperoxide reductase activity
DWB40_RS17015	COG0583	DNA-binding transcription factor activity
DWB40_RS17020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWB40_RS17030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB40_RS17040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DWB40_RS17060	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DWB40_RS17065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWB40_RS17070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB40_RS17075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB40_RS17085	COG2096	Adenosyltransferase
DWB40_RS17095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DWB40_RS17100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DWB40_RS17105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DWB40_RS17110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWB40_RS17115	COG2967	ApaG domain
DWB40_RS17120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DWB40_RS17125	COG3738	Protein conserved in bacteria
DWB40_RS17135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DWB40_RS17140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DWB40_RS17155	COG1704	LemA family
DWB40_RS17160	COG2814	Major facilitator Superfamily
DWB40_RS17165	COG0861	Integral membrane protein TerC family
DWB40_RS17170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DWB40_RS17180	COG0642	Histidine kinase
DWB40_RS17195	COG4181	ATPase activity
DWB40_RS17200	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DWB40_RS17220	COG4771	TonB-dependent receptor
DWB40_RS17230	COG0667	Aldo Keto reductase
DWB40_RS17235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB40_RS17240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB40_RS17260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DWB40_RS17265	COG4106	trans-aconitate 2-methyltransferase activity
DWB40_RS17295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWB40_RS17300	COG1607	acyl-coa hydrolase
DWB40_RS17320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DWB40_RS17330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DWB40_RS17335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DWB40_RS17355	COG3279	Response regulator of the LytR AlgR family
DWB40_RS17360	COG3275	phosphorelay sensor kinase activity
DWB40_RS17370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DWB40_RS17380	COG0494	nUDIX hydrolase
DWB40_RS17385	COG0653	protein targeting
DWB40_RS17390	COG0739	heme binding
DWB40_RS17400	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DWB40_RS17405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DWB40_RS17415	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DWB40_RS17420	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWB40_RS17425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DWB40_RS17445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DWB40_RS17460	COG3116	cell division
DWB40_RS17465	COG0275	rRNA processing
DWB40_RS17470	COG2001	Belongs to the MraZ family
DWB40_RS17505	COG1988	membrane-bound metal-dependent
DWB40_RS17510	COG0277	FAD linked oxidase domain protein
DWB40_RS17515	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DWB40_RS17515	COG2755	lipolytic protein G-D-S-L family
DWB40_RS17525	COG3188	usher protein
DWB40_RS17540	COG3121	Chaperone
DWB40_RS17550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB40_RS17555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWB40_RS17590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB40_RS17590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB40_RS17595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DWB40_RS17615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWB40_RS17625	COG0488	(ABC) transporter
DWB40_RS17630	COG2252	PERMEase
DWB40_RS17645	COG1215	transferase activity, transferring glycosyl groups
DWB40_RS17655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DWB40_RS17675	COG3539	Fimbrial protein
DWB40_RS17685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DWB40_RS17690	COG0463	Glycosyl transferase, family 2
DWB40_RS17700	COG1450	Type ii and iii secretion system protein
DWB40_RS17715	COG3166	PFAM Fimbrial assembly family protein
DWB40_RS17720	COG3156	type II secretion system protein K
DWB40_RS17725	COG4795	General secretion pathway protein
DWB40_RS17730	COG2165	general secretion pathway protein
DWB40_RS17735	COG4970	Tfp pilus assembly protein FimT
DWB40_RS17740	COG2165	general secretion pathway protein
DWB40_RS17745	COG1459	type II secretion system
DWB40_RS17750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DWB40_RS17755	COG1404	Belongs to the peptidase S8 family
DWB40_RS17760	COG5295	Hep Hag repeat protein
DWB40_RS17765	COG0047	phosphoribosylformylglycinamidine synthase activity
DWB40_RS17765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB40_RS17775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DWB40_RS17780	COG4974	Belongs to the 'phage' integrase family
DWB40_RS17795	COG0795	lipopolysaccharide-transporting ATPase activity
DWB40_RS17805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWB40_RS17815	COG0525	valine-tRNA ligase activity
DWB40_RS17825	COG0456	acetyltransferase
DWB40_RS17835	COG1183	phosphatidylcholine synthase activity
DWB40_RS17845	COG0442	prolyl-tRNA aminoacylation
DWB40_RS17860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DWB40_RS17865	COG1127	ABC transporter
DWB40_RS17900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWB40_RS17905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB40_RS17950	COG0463	Glycosyl transferase, family 2
DWB40_RS17985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DWB40_RS18000	COG1215	transferase activity, transferring glycosyl groups
DWB40_RS18025	COG0626	cystathionine gamma-synthase activity
DWB40_RS18065	COG0625	glutathione transferase activity
DWB40_RS18075	COG0513	Belongs to the DEAD box helicase family
DWB40_RS18090	COG0720	synthase
DWB40_RS18100	COG0367	asparagine synthase
DWB40_RS18105	COG0745	RESPONSE REGULATOR receiver
DWB40_RS18110	COG2205	protein histidine kinase activity
DWB40_RS18115	COG2205	protein histidine kinase activity
DWB40_RS18120	COG0745	RESPONSE REGULATOR receiver
DWB40_RS18125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB40_RS18130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB40_RS18130	COG0785	Cytochrome C biogenesis protein
DWB40_RS18135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB40_RS18140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB40_RS18145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DWB40_RS18150	COG1956	GAF domain-containing protein
DWB40_RS18175	COG2226	methyltransferase
DWB40_RS18180	COG0583	DNA-binding transcription factor activity
DWB40_RS18195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB40_RS18200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DWB40_RS18210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWB40_RS18215	COG1187	pseudouridine synthase activity
DWB40_RS18220	COG2813	Specifically methylates the guanine in position
DWB40_RS18235	COG5002	protein histidine kinase activity
DWB40_RS18250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB40_RS18280	COG1360	Flagellar Motor Protein
DWB40_RS18305	COG0025	NhaP-type Na H and K H
DWB40_RS18310	COG3384	dioxygenase
DWB40_RS18320	COG0583	DNA-binding transcription factor activity
DWB40_RS18325	COG5001	Diguanylate cyclase
DWB40_RS18330	COG3590	peptidase
DWB40_RS18345	COG1309	transcriptional regulator
DWB40_RS18365	COG3279	Response regulator of the LytR AlgR family
DWB40_RS18370	COG3275	phosphorelay sensor kinase activity
DWB40_RS18400	COG4941	Belongs to the sigma-70 factor family
DWB40_RS18405	COG5507	3-demethylubiquinone-9 3-methyltransferase
DWB40_RS18415	COG2764	glyoxalase bleomycin resistance protein dioxygenase
DWB40_RS18440	COG0741	lytic transglycosylase activity
DWB40_RS18445	COG1113	amino acid transport
DWB40_RS18450	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DWB40_RS18455	COG2814	Major facilitator Superfamily
DWB40_RS18465	COG0583	DNA-binding transcription factor activity
DWB40_RS18470	COG0488	(ABC) transporter
DWB40_RS18535	COG2267	carboxylic ester hydrolase activity
DWB40_RS18600	COG3727	T/G mismatch-specific endonuclease activity
DWB40_RS18605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWB40_RS18625	COG5290	Psort location Cytoplasmic, score
DWB40_RS18640	COG2375	cellular response to nickel ion
DWB40_RS18655	COG2353	YceI-like domain
DWB40_RS18660	COG0778	Nitroreductase
DWB40_RS18690	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DWB40_RS18695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DWB40_RS18705	COG5383	Protein conserved in bacteria
DWB40_RS18735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB40_RS18755	COG4948	Mandelate Racemase Muconate Lactonizing
DWB40_RS18760	COG1737	Transcriptional regulator
DWB40_RS18770	COG0531	amino acid
DWB40_RS18780	COG4682	membrane
DWB40_RS18785	COG2133	pyrroloquinoline quinone binding
DWB40_RS18800	COG0668	transmembrane transport
DWB40_RS18805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DWB40_RS18815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWB40_RS18830	COG1295	ribonuclease BN
DWB40_RS18835	COG0358	DNA primase activity
DWB40_RS18855	COG0109	protoheme IX farnesyltransferase activity
DWB40_RS18900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DWB40_RS18925	COG2067	long-chain fatty acid transport protein
DWB40_RS18940	COG0793	Belongs to the peptidase S41A family
DWB40_RS18945	COG4942	peptidase
DWB40_RS18955	COG2234	aminopeptidase activity
DWB40_RS19015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DWB40_RS19020	COG0739	heme binding
DWB40_RS19035	COG2223	nitrite transmembrane transporter activity
DWB40_RS19040	COG0708	Exodeoxyribonuclease III
DWB40_RS19045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DWB40_RS19060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DWB40_RS19065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DWB40_RS19075	COG2205	protein histidine kinase activity
DWB40_RS19095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DWB40_RS19100	COG2197	response regulator
DWB40_RS19105	COG2003	Belongs to the UPF0758 family
DWB40_RS19110	COG0018	arginyl-trna synthetase
DWB40_RS19120	COG4221	oxidoreductase activity
DWB40_RS19130	COG4807	Protein conserved in bacteria
DWB40_RS19135	COG0583	DNA-binding transcription factor activity
DWB40_RS19140	COG2814	Major facilitator Superfamily
DWB40_RS19155	COG2197	response regulator
DWB40_RS19170	COG5507	3-demethylubiquinone-9 3-methyltransferase
DWB40_RS19185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB40_RS19205	COG0628	permease
DWB40_RS19220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWB40_RS19235	COG2197	response regulator
DWB40_RS19240	COG4585	Histidine kinase
DWB40_RS19260	COG1136	(ABC) transporter
DWB40_RS19270	COG0577	efflux transmembrane transporter activity
DWB40_RS19270	COG1136	(ABC) transporter
DWB40_RS19285	COG0697	spore germination
DWB40_RS19290	COG0477	Major facilitator Superfamily
DWB40_RS19315	COG0180	Tryptophanyl-tRNA synthetase
DWB40_RS19325	COG3237	CsbD-like
DWB40_RS19375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DWB40_RS19380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DWB40_RS19380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DWB40_RS19390	COG3228	Belongs to the MtfA family
DWB40_RS19410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DWB40_RS19435	COG1764	response to oxidative stress
DWB40_RS19445	COG1024	Enoyl-CoA hydratase
DWB40_RS19450	COG1024	Enoyl-CoA hydratase
DWB40_RS19455	COG1960	acyl-CoA dehydrogenase activity
DWB40_RS19465	COG1396	sequence-specific DNA binding
DWB40_RS19465	COG3800	Transcriptional regulator
DWB40_RS19475	COG1752	Esterase of the alpha-beta hydrolase superfamily
DWB40_RS19480	COG1051	belongs to the nudix hydrolase family
DWB40_RS19480	COG1056	cytidyltransferase-related domain
DWB40_RS19490	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB40_RS19495	COG1335	isochorismatase
DWB40_RS19515	COG1902	pentaerythritol trinitrate reductase activity
DWB40_RS19525	COG1607	acyl-coa hydrolase
DWB40_RS19530	COG1280	lysine exporter protein (LysE YggA)
DWB40_RS19540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB40_RS19550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DWB40_RS19560	COG0697	spore germination
DWB40_RS19580	COG1960	acyl-CoA dehydrogenase activity
DWB40_RS19585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWB40_RS19610	COG3706	GGDEF domain
DWB40_RS19615	COG2224	Isocitrate lyase
DWB40_RS19620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DWB40_RS19625	COG0583	DNA-binding transcription factor activity
DWB40_RS19630	COG0583	DNA-binding transcription factor activity
DWB40_RS19635	COG2801	Transposase and inactivated derivatives
DWB40_RS19635	COG3415	Transposase
DWB40_RS19640	COG2814	Major facilitator Superfamily
DWB40_RS19645	COG0681	Belongs to the peptidase S26 family
DWB40_RS19660	COG0339	signal peptide processing
DWB40_RS19690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB40_RS19695	COG1215	transferase activity, transferring glycosyl groups
DWB40_RS19710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DWB40_RS19720	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWB40_RS19730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB40_RS19735	COG0318	PFAM AMP-dependent synthetase and ligase
DWB40_RS19745	COG0596	Alpha beta hydrolase
DWB40_RS19750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB40_RS19760	COG0612	Peptidase, M16
DWB40_RS19770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DWB40_RS19775	COG1960	acyl-CoA dehydrogenase activity
DWB40_RS19785	COG3474	cytochrome
DWB40_RS19790	COG2205	protein histidine kinase activity
DWB40_RS19790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB40_RS19795	COG2197	response regulator
DWB40_RS19840	COG2837	iron assimilation
DWB40_RS19875	COG0431	NADPH-dependent FMN reductase
DWB40_RS19890	COG0798	PFAM Bile acid sodium symporter
DWB40_RS19910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DWB40_RS19915	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DWB40_RS19950	COG0183	Belongs to the thiolase family
DWB40_RS19960	COG2032	superoxide dismutase activity
DWB40_RS19965	COG2032	superoxide dismutase activity
DWB40_RS19970	COG2204	response regulator
DWB40_RS19975	COG3852	Histidine kinase
DWB40_RS19990	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DWB40_RS20005	COG0347	Belongs to the P(II) protein family
DWB40_RS20010	COG0174	glutamine synthetase
DWB40_RS20015	COG1968	undecaprenyl-diphosphatase activity
DWB40_RS20030	COG1881	PFAM PEBP family protein
DWB40_RS20055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWB40_RS20075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWB40_RS20095	COG3550	peptidyl-serine autophosphorylation
DWB40_RS20105	COG0312	modulator of DNA gyrase
DWB40_RS20125	COG0714	Associated with various cellular activities
DWB40_RS20160	COG1205	dead DEAH box helicase
DWB40_RS20160	COG1111	helicase
DWB40_RS20185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB40_RS20200	COG1028	Short-chain dehydrogenase reductase Sdr
DWB40_RS20220	COG0067	glutamate synthase
DWB40_RS20220	COG0069	glutamate synthase activity
DWB40_RS20220	COG0070	glutamate synthase
DWB40_RS20225	COG0493	'glutamate synthase
DWB40_RS20230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB40_RS20230	COG2205	protein histidine kinase activity
DWB40_RS20235	COG1803	Methylglyoxal synthase
DWB40_RS20245	COG2974	May be involved in recombination
DWB40_RS20250	COG0037	tRNA processing
DWB40_RS20260	COG2937	Belongs to the GPAT DAPAT family
DWB40_RS20270	COG0284	orotidine-5'-phosphate decarboxylase activity
DWB40_RS20275	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DWB40_RS20280	COG3132	Protein of unknown function, DUF480
DWB40_RS20290	COG0210	DNA helicase
DWB40_RS20310	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DWB40_RS20315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWB40_RS20330	COG1122	ATPase activity
DWB40_RS20350	COG4771	TonB-dependent receptor
DWB40_RS20360	COG1752	Esterase of the alpha-beta hydrolase superfamily
DWB40_RS20365	COG1522	sequence-specific DNA binding
DWB40_RS20370	COG3186	Phenylalanine-4-hydroxylase
DWB40_RS20385	COG0800	Aldolase
DWB40_RS20420	COG4772	TonB-dependent receptor
DWB40_RS20430	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DWB40_RS20505	COG0501	Belongs to the peptidase M48B family
DWB40_RS20510	COG1266	CAAX protease self-immunity
DWB40_RS20515	COG0187	DNA topoisomerase II activity
DWB40_RS20520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DWB40_RS20530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DWB40_RS20535	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DWB40_RS20540	COG0594	ribonuclease P activity
DWB40_RS20545	COG0706	membrane insertase activity
DWB40_RS20560	COG0584	glycerophosphoryl diester phosphodiesterase
DWB40_RS20570	COG0861	Integral membrane protein TerC family
DWB40_RS20575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DWB40_RS20585	COG0531	amino acid
DWB40_RS20605	COG0583	DNA-binding transcription factor activity
DWB40_RS20610	COG0604	alcohol dehydrogenase
DWB40_RS20620	COG1322	Protein conserved in bacteria
DWB40_RS20630	COG0386	Belongs to the glutathione peroxidase family
DWB40_RS20635	COG2853	Lipoprotein
DWB40_RS20650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DWB40_RS20655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DWB40_RS20660	COG1127	ABC transporter
DWB40_RS20665	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DWB40_RS20670	COG1074	ATP-dependent DNA helicase activity
DWB40_RS20685	COG1289	transmembrane transporter activity
DWB40_RS20710	COG0302	gtp cyclohydrolase
DWB40_RS20740	COG3706	GGDEF domain
DWB40_RS20745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DWB40_RS20750	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DWB40_RS20755	COG2951	lytic endotransglycosylase activity
DWB40_RS20770	COG3135	benzoate transporter