locus-tag	class	description
SMD_RS00115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMD_RS00125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMD_RS00130	COG0187	DNA topoisomerase II activity
SMD_RS00135	COG1266	CAAX protease self-immunity
SMD_RS00140	COG0501	Belongs to the peptidase M48B family
SMD_RS00170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMD_RS00210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMD_RS00220	COG4772	TonB-dependent receptor
SMD_RS00255	COG0800	Aldolase
SMD_RS00265	COG1609	Transcriptional regulator
SMD_RS00270	COG3186	Phenylalanine-4-hydroxylase
SMD_RS00275	COG1522	sequence-specific DNA binding
SMD_RS00280	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMD_RS00310	COG1122	ATPase activity
SMD_RS00330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMD_RS00335	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SMD_RS00355	COG0210	DNA helicase
SMD_RS00375	COG3209	COG3209 Rhs family protein
SMD_RS00390	COG3132	Protein of unknown function, DUF480
SMD_RS00395	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SMD_RS00400	COG0284	orotidine-5'-phosphate decarboxylase activity
SMD_RS00405	COG5640	endopeptidase activity
SMD_RS00415	COG2937	Belongs to the GPAT DAPAT family
SMD_RS00425	COG0037	tRNA processing
SMD_RS00430	COG2974	May be involved in recombination
SMD_RS00440	COG1803	Methylglyoxal synthase
SMD_RS00450	COG0493	'glutamate synthase
SMD_RS00455	COG0067	glutamate synthase
SMD_RS00455	COG0070	glutamate synthase
SMD_RS00455	COG0069	glutamate synthase activity
SMD_RS00475	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS00490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMD_RS00520	COG1205	dead DEAH box helicase
SMD_RS00520	COG1111	helicase
SMD_RS00555	COG0714	Associated with various cellular activities
SMD_RS00575	COG0312	modulator of DNA gyrase
SMD_RS00595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMD_RS00615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMD_RS00640	COG1881	PFAM PEBP family protein
SMD_RS00645	COG0431	NADPH-dependent FMN reductase
SMD_RS00655	COG1968	undecaprenyl-diphosphatase activity
SMD_RS00660	COG0174	glutamine synthetase
SMD_RS00665	COG0347	Belongs to the P(II) protein family
SMD_RS00670	COG0004	ammonium transporteR
SMD_RS00720	COG3852	Histidine kinase
SMD_RS00725	COG2204	response regulator
SMD_RS00730	COG2032	superoxide dismutase activity
SMD_RS00735	COG2032	superoxide dismutase activity
SMD_RS00745	COG0183	Belongs to the thiolase family
SMD_RS00780	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SMD_RS00785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMD_RS00805	COG0798	PFAM Bile acid sodium symporter
SMD_RS00810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD_RS00820	COG0431	NADPH-dependent FMN reductase
SMD_RS00850	COG2801	Transposase and inactivated derivatives
SMD_RS00855	COG2963	transposase activity
SMD_RS00975	COG2837	iron assimilation
SMD_RS01020	COG2197	response regulator
SMD_RS01025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD_RS01025	COG2205	protein histidine kinase activity
SMD_RS01030	COG3474	cytochrome
SMD_RS01040	COG1960	acyl-CoA dehydrogenase activity
SMD_RS01050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SMD_RS01060	COG0612	Peptidase, M16
SMD_RS01070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD_RS01075	COG0596	Alpha beta hydrolase
SMD_RS01085	COG0318	PFAM AMP-dependent synthetase and ligase
SMD_RS01090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD_RS01100	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMD_RS01115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMD_RS01130	COG1215	transferase activity, transferring glycosyl groups
SMD_RS01135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SMD_RS01140	COG4122	O-methyltransferase activity
SMD_RS01165	COG0339	signal peptide processing
SMD_RS01180	COG0681	Belongs to the peptidase S26 family
SMD_RS01185	COG2814	Major facilitator Superfamily
SMD_RS01190	COG0583	DNA-binding transcription factor activity
SMD_RS01195	COG0583	DNA-binding transcription factor activity
SMD_RS01200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMD_RS01205	COG2224	Isocitrate lyase
SMD_RS01235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMD_RS01240	COG1960	acyl-CoA dehydrogenase activity
SMD_RS01260	COG0697	spore germination
SMD_RS01270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SMD_RS01285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD_RS01290	COG1280	lysine exporter protein (LysE YggA)
SMD_RS01295	COG1607	acyl-coa hydrolase
SMD_RS01305	COG1902	pentaerythritol trinitrate reductase activity
SMD_RS01320	COG1335	isochorismatase
SMD_RS01325	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMD_RS01335	COG1051	belongs to the nudix hydrolase family
SMD_RS01335	COG1056	cytidyltransferase-related domain
SMD_RS01340	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMD_RS01345	COG3800	Transcriptional regulator
SMD_RS01345	COG1396	sequence-specific DNA binding
SMD_RS01355	COG1960	acyl-CoA dehydrogenase activity
SMD_RS01360	COG1024	Enoyl-CoA hydratase
SMD_RS01365	COG1024	Enoyl-CoA hydratase
SMD_RS01375	COG1764	response to oxidative stress
SMD_RS01485	COG0659	secondary active sulfate transmembrane transporter activity
SMD_RS01505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMD_RS01525	COG3228	Belongs to the MtfA family
SMD_RS01535	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SMD_RS01535	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SMD_RS01540	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SMD_RS01560	COG2801	Transposase and inactivated derivatives
SMD_RS01565	COG2963	transposase activity
SMD_RS01610	COG3237	CsbD-like
SMD_RS01620	COG0180	Tryptophanyl-tRNA synthetase
SMD_RS01645	COG0477	Major facilitator Superfamily
SMD_RS01650	COG0697	spore germination
SMD_RS01660	COG4206	TonB-dependent receptor
SMD_RS01670	COG1136	(ABC) transporter
SMD_RS01670	COG0577	efflux transmembrane transporter activity
SMD_RS01680	COG1136	(ABC) transporter
SMD_RS01685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS01690	COG4585	Histidine kinase
SMD_RS01695	COG2197	response regulator
SMD_RS01700	COG3038	cytochrome b561
SMD_RS01710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMD_RS01725	COG0628	permease
SMD_RS01745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD_RS01760	COG5507	3-demethylubiquinone-9 3-methyltransferase
SMD_RS01790	COG2814	Major facilitator Superfamily
SMD_RS01795	COG0583	DNA-binding transcription factor activity
SMD_RS01800	COG4807	Protein conserved in bacteria
SMD_RS01805	COG4221	oxidoreductase activity
SMD_RS01815	COG0018	arginyl-trna synthetase
SMD_RS01820	COG2003	Belongs to the UPF0758 family
SMD_RS01825	COG2197	response regulator
SMD_RS01830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMD_RS01855	COG2205	protein histidine kinase activity
SMD_RS01865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMD_RS01870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMD_RS01885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMD_RS01890	COG0708	Exodeoxyribonuclease III
SMD_RS01895	COG2211	Major facilitator Superfamily
SMD_RS01910	COG0739	heme binding
SMD_RS01975	COG2234	aminopeptidase activity
SMD_RS01985	COG4942	peptidase
SMD_RS01990	COG0793	Belongs to the peptidase S41A family
SMD_RS02000	COG2067	long-chain fatty acid transport protein
SMD_RS02025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMD_RS02070	COG0109	protoheme IX farnesyltransferase activity
SMD_RS02090	COG0358	DNA primase activity
SMD_RS02095	COG1295	ribonuclease BN
SMD_RS02110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMD_RS02120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMD_RS02125	COG0668	transmembrane transport
SMD_RS02140	COG2133	pyrroloquinoline quinone binding
SMD_RS02145	COG4682	membrane
SMD_RS02155	COG0531	amino acid
SMD_RS02165	COG1737	Transcriptional regulator
SMD_RS02170	COG4948	Mandelate Racemase Muconate Lactonizing
SMD_RS02220	COG5383	Protein conserved in bacteria
SMD_RS02235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SMD_RS02265	COG0778	Nitroreductase
SMD_RS02270	COG2353	YceI-like domain
SMD_RS02285	COG2375	cellular response to nickel ion
SMD_RS02380	COG2267	carboxylic ester hydrolase activity
SMD_RS02445	COG0488	(ABC) transporter
SMD_RS02450	COG0583	DNA-binding transcription factor activity
SMD_RS02460	COG2814	Major facilitator Superfamily
SMD_RS02465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SMD_RS02470	COG1113	amino acid transport
SMD_RS02475	COG0741	lytic transglycosylase activity
SMD_RS02490	COG3795	YCII-related domain
SMD_RS02500	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SMD_RS02510	COG5507	3-demethylubiquinone-9 3-methyltransferase
SMD_RS02515	COG4941	Belongs to the sigma-70 factor family
SMD_RS02545	COG3275	phosphorelay sensor kinase activity
SMD_RS02550	COG3279	Response regulator of the LytR AlgR family
SMD_RS02570	COG1309	transcriptional regulator
SMD_RS02580	COG2814	Major facilitator Superfamily
SMD_RS02585	COG3590	peptidase
SMD_RS02590	COG5001	Diguanylate cyclase
SMD_RS02595	COG0583	DNA-binding transcription factor activity
SMD_RS02605	COG3384	dioxygenase
SMD_RS02610	COG0025	NhaP-type Na H and K H
SMD_RS02635	COG1360	Flagellar Motor Protein
SMD_RS02665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD_RS02680	COG5002	protein histidine kinase activity
SMD_RS02695	COG2813	Specifically methylates the guanine in position
SMD_RS02700	COG1187	pseudouridine synthase activity
SMD_RS02705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMD_RS02715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMD_RS02720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMD_RS02735	COG0583	DNA-binding transcription factor activity
SMD_RS02740	COG2226	methyltransferase
SMD_RS02745	COG0546	phosphoglycolate phosphatase activity
SMD_RS02750	COG4206	TonB-dependent receptor
SMD_RS02765	COG1956	GAF domain-containing protein
SMD_RS02770	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMD_RS02775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD_RS02780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMD_RS02785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMD_RS02785	COG0785	Cytochrome C biogenesis protein
SMD_RS02790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMD_RS02795	COG0745	RESPONSE REGULATOR receiver
SMD_RS02800	COG5002	protein histidine kinase activity
SMD_RS02805	COG2205	protein histidine kinase activity
SMD_RS02810	COG0745	RESPONSE REGULATOR receiver
SMD_RS02815	COG0367	asparagine synthase
SMD_RS02825	COG0720	synthase
SMD_RS02840	COG0513	Belongs to the DEAD box helicase family
SMD_RS02850	COG0625	glutathione transferase activity
SMD_RS02855	COG1573	uracil-dna glycosylase
SMD_RS02890	COG0626	cystathionine gamma-synthase activity
SMD_RS02905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD_RS02910	COG3754	Rhamnan synthesis protein F
SMD_RS02915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMD_RS02925	COG2246	polysaccharide biosynthetic process
SMD_RS02940	COG2801	Transposase and inactivated derivatives
SMD_RS02955	COG2801	Transposase and inactivated derivatives
SMD_RS02960	COG2963	transposase activity
SMD_RS03005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMD_RS03035	COG1127	ABC transporter
SMD_RS03040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMD_RS03055	COG0442	prolyl-tRNA aminoacylation
SMD_RS03065	COG1183	phosphatidylcholine synthase activity
SMD_RS03075	COG0456	acetyltransferase
SMD_RS03085	COG0525	valine-tRNA ligase activity
SMD_RS03100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMD_RS03110	COG0795	lipopolysaccharide-transporting ATPase activity
SMD_RS03120	COG4974	Belongs to the 'phage' integrase family
SMD_RS03125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMD_RS03135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMD_RS03135	COG0047	phosphoribosylformylglycinamidine synthase activity
SMD_RS03145	COG1404	Belongs to the peptidase S8 family
SMD_RS03150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMD_RS03155	COG1459	type II secretion system
SMD_RS03160	COG2165	general secretion pathway protein
SMD_RS03165	COG4970	Tfp pilus assembly protein FimT
SMD_RS03170	COG2165	general secretion pathway protein
SMD_RS03175	COG4795	General secretion pathway protein
SMD_RS03180	COG3156	type II secretion system protein K
SMD_RS03185	COG3166	PFAM Fimbrial assembly family protein
SMD_RS03200	COG1450	Type ii and iii secretion system protein
SMD_RS03225	COG3539	Fimbrial protein
SMD_RS03230	COG3121	Chaperone
SMD_RS03245	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMD_RS03255	COG1215	transferase activity, transferring glycosyl groups
SMD_RS03270	COG2252	PERMEase
SMD_RS03275	COG0488	(ABC) transporter
SMD_RS03285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMD_RS03300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMD_RS03305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMD_RS03305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMD_RS03335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMD_RS03340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMD_RS03355	COG3152	Membrane
SMD_RS03375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMD_RS03375	COG2755	lipolytic protein G-D-S-L family
SMD_RS03380	COG0277	FAD linked oxidase domain protein
SMD_RS03385	COG1988	membrane-bound metal-dependent
SMD_RS03420	COG2001	Belongs to the MraZ family
SMD_RS03425	COG0275	rRNA processing
SMD_RS03430	COG3116	cell division
SMD_RS03445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMD_RS03465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMD_RS03470	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMD_RS03475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SMD_RS03485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMD_RS03490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SMD_RS03500	COG0739	heme binding
SMD_RS03505	COG0653	protein targeting
SMD_RS03510	COG0494	nUDIX hydrolase
SMD_RS03520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMD_RS03530	COG3275	phosphorelay sensor kinase activity
SMD_RS03555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMD_RS03560	COG3409	Peptidoglycan-binding domain 1 protein
SMD_RS03560	COG3773	Cell wall hydrolase
SMD_RS03570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMD_RS03580	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMD_RS03585	COG1607	acyl-coa hydrolase
SMD_RS03590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMD_RS03610	COG4106	trans-aconitate 2-methyltransferase activity
SMD_RS03615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMD_RS03625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD_RS03630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SMD_RS03635	COG0667	Aldo Keto reductase
SMD_RS03645	COG4771	TonB-dependent receptor
SMD_RS03660	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SMD_RS03665	COG4181	ATPase activity
SMD_RS03680	COG0642	Histidine kinase
SMD_RS03690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMD_RS03695	COG0861	Integral membrane protein TerC family
SMD_RS03700	COG2814	Major facilitator Superfamily
SMD_RS03705	COG1704	LemA family
SMD_RS03720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMD_RS03725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMD_RS03735	COG3738	Protein conserved in bacteria
SMD_RS03740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMD_RS03745	COG2967	ApaG domain
SMD_RS03750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMD_RS03755	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMD_RS03765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SMD_RS03775	COG2096	Adenosyltransferase
SMD_RS03785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD_RS03790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD_RS03795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMD_RS03800	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
SMD_RS03820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMD_RS03830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMD_RS03840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMD_RS03845	COG0583	DNA-binding transcription factor activity
SMD_RS03850	COG3634	alkyl hydroperoxide reductase activity
SMD_RS03905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SMD_RS03945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMD_RS03950	COG1404	Belongs to the peptidase S8 family
SMD_RS03970	COG1295	ribonuclease BN
SMD_RS03975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMD_RS03990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMD_RS03995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMD_RS04010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMD_RS04020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMD_RS04025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMD_RS04030	COG0193	aminoacyl-tRNA hydrolase activity
SMD_RS04035	COG0012	GTP binding
SMD_RS04045	COG2197	response regulator
SMD_RS04050	COG2205	protein histidine kinase activity
SMD_RS04050	COG0784	Response regulator, receiver
SMD_RS04055	COG2199	diguanylate cyclase activity
SMD_RS04055	COG2203	Gaf domain
SMD_RS04055	COG2200	EAL domain
SMD_RS04060	COG2205	protein histidine kinase activity
SMD_RS04060	COG0784	Response regulator, receiver
SMD_RS04065	COG4206	TonB-dependent receptor
SMD_RS04070	COG4242	Belongs to the peptidase S51 family
SMD_RS04095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMD_RS04105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMD_RS04110	COG0250	Participates in transcription elongation, termination and antitermination
SMD_RS04115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMD_RS04120	COG0081	regulation of translation
SMD_RS04125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMD_RS04130	COG0222	ribosome binding
SMD_RS04135	COG0085	RNA polymerase activity
SMD_RS04140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMD_RS04145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMD_RS04150	COG0049	tRNA binding
SMD_RS04155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMD_RS04160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMD_RS04165	COG0051	transcription antitermination factor activity, RNA binding
SMD_RS04170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMD_RS04175	COG0088	Forms part of the polypeptide exit tunnel
SMD_RS04180	COG0089	rRNA binding
SMD_RS04185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMD_RS04190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMD_RS04195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMD_RS04200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMD_RS04205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMD_RS04210	COG0255	Belongs to the universal ribosomal protein uL29 family
SMD_RS04215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMD_RS04220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMD_RS04225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMD_RS04230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMD_RS04235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMD_RS04240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMD_RS04245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMD_RS04250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMD_RS04255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMD_RS04260	COG1841	ribosomal large subunit assembly
SMD_RS04265	COG0200	Binds to the 23S rRNA
SMD_RS04270	COG0201	protein transport
SMD_RS04275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMD_RS04280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMD_RS04285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMD_RS04290	COG0202	RNA polymerase activity
SMD_RS04295	COG0203	ribosomal protein L17
SMD_RS04310	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMD_RS04320	COG0154	amidase activity
SMD_RS04335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMD_RS04340	COG0039	L-malate dehydrogenase activity
SMD_RS04345	COG0564	pseudouridine synthase activity
SMD_RS04350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMD_RS04365	COG0625	glutathione transferase activity
SMD_RS04375	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMD_RS04375	COG1902	pentaerythritol trinitrate reductase activity
SMD_RS04380	COG2364	Membrane
SMD_RS04385	COG0604	alcohol dehydrogenase
SMD_RS04400	COG1187	pseudouridine synthase activity
SMD_RS04420	COG1063	alcohol dehydrogenase
SMD_RS04430	COG0588	phosphoglycerate mutase activity
SMD_RS04435	COG0285	dihydrofolate synthase activity
SMD_RS04455	COG2833	Protein of unknown function (DUF455)
SMD_RS04465	COG3291	Pkd domain containing protein
SMD_RS04470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMD_RS04475	COG0671	phosphoesterase, PA-phosphatase related
SMD_RS04480	COG0438	transferase activity, transferring glycosyl groups
SMD_RS04490	COG0248	Ppx GppA phosphatase
SMD_RS04495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMD_RS04510	COG4783	chaperone-mediated protein folding
SMD_RS04525	COG0473	3-isopropylmalate dehydrogenase activity
SMD_RS04590	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMD_RS04595	COG0740	serine-type endopeptidase activity
SMD_RS04600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMD_RS04640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMD_RS04700	COG1475	DNA binding
SMD_RS04710	COG5489	Protein of unknown function (DUF736)
SMD_RS04765	COG4959	Type IV secretory pathway protease TraF
SMD_RS04775	COG2205	protein histidine kinase activity
SMD_RS04780	COG0745	RESPONSE REGULATOR receiver
SMD_RS04815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS04820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS04840	COG3713	MltA-interacting MipA family protein
SMD_RS04860	COG0583	DNA-binding transcription factor activity
SMD_RS04880	COG4962	Type ii secretion system protein e
SMD_RS04885	COG3838	Conjugal transfer protein Trbc
SMD_RS04895	COG3451	type IV secretory pathway VirB4
SMD_RS04940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMD_RS04950	COG0328	RNA-DNA hybrid ribonuclease activity
SMD_RS04955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMD_RS04960	COG0631	protein serine/threonine phosphatase activity
SMD_RS04975	COG0859	PFAM glycosyl transferase family 9
SMD_RS04980	COG3642	lipopolysaccharide core region biosynthetic process
SMD_RS04985	COG1234	tRNA 3'-trailer cleavage
SMD_RS04995	COG2076	Multidrug Resistance protein
SMD_RS05075	COG2885	chlorophyll binding
SMD_RS05075	COG3047	cAMP biosynthetic process
SMD_RS05095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMD_RS05105	COG0537	adenosine 5'-monophosphoramidase activity
SMD_RS05125	COG0714	Associated with various cellular activities
SMD_RS05140	COG1399	metal-binding, possibly nucleic acid-binding protein
SMD_RS05145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMD_RS05150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMD_RS05160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMD_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS05175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD_RS05180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMD_RS05185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMD_RS05190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMD_RS05220	COG1942	4-Oxalocrotonate Tautomerase
SMD_RS05240	COG4774	siderophore transport
SMD_RS05250	COG2223	nitrite transmembrane transporter activity
SMD_RS05270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD_RS05275	COG0697	spore germination
SMD_RS05280	COG0583	DNA-binding transcription factor activity
SMD_RS05285	COG0477	Major facilitator Superfamily
SMD_RS05320	COG0583	DNA-binding transcription factor activity
SMD_RS05330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMD_RS05345	COG0667	Aldo Keto reductase
SMD_RS05365	COG2818	Glycosylase
SMD_RS05370	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SMD_RS05375	COG1678	Uncharacterized ACR, COG1678
SMD_RS05380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMD_RS05385	COG0540	Belongs to the ATCase OTCase family
SMD_RS05405	COG2239	Acts as a magnesium transporter
SMD_RS05410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD_RS05425	COG1660	Displays ATPase and GTPase activities
SMD_RS05430	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SMD_RS05435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMD_RS05440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMD_RS05450	COG1137	ATPase activity
SMD_RS05465	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SMD_RS05480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMD_RS05500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMD_RS05520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMD_RS05530	COG0628	permease
SMD_RS05540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMD_RS05545	COG3178	'Phosphotransferase
SMD_RS05550	COG2261	transglycosylase associated protein
SMD_RS05560	COG1555	photosystem II stabilization
SMD_RS05580	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SMD_RS05585	COG1477	protein flavinylation
SMD_RS05605	COG4771	TonB-dependent receptor
SMD_RS05615	COG3128	pkhd-type hydroxylase
SMD_RS05625	COG4774	siderophore transport
SMD_RS05635	COG2146	nitrite reductase [NAD(P)H] activity
SMD_RS05650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMD_RS05655	COG0719	Fe-S assembly protein
SMD_RS05660	COG0396	ATPase activity
SMD_RS05665	COG0719	Fe-S assembly protein
SMD_RS05670	COG1959	2 iron, 2 sulfur cluster binding
SMD_RS05680	COG0693	protein deglycase activity
SMD_RS05705	COG1764	response to oxidative stress
SMD_RS05710	COG0384	phenazine biosynthesis protein PhzF
SMD_RS05715	COG0384	phenazine biosynthesis protein PhzF
SMD_RS05720	COG0527	aspartate kinase activity
SMD_RS05730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMD_RS05755	COG0142	geranyltranstransferase activity
SMD_RS05760	COG0366	Alpha amylase catalytic
SMD_RS05770	COG1082	Xylose isomerase domain protein TIM barrel
SMD_RS05780	COG2190	(PTS) system
SMD_RS05780	COG2211	Major facilitator Superfamily
SMD_RS05805	COG1131	(ABC) transporter
SMD_RS05815	COG0629	single-stranded DNA binding
SMD_RS05845	COG2010	Cytochrome c
SMD_RS05860	COG2211	Major facilitator Superfamily
SMD_RS05870	COG1609	Transcriptional regulator
SMD_RS05910	COG0640	Transcriptional regulator
SMD_RS05925	COG3655	Transcriptional regulator
SMD_RS05930	COG1253	flavin adenine dinucleotide binding
SMD_RS05935	COG1408	metallophosphoesterase
SMD_RS05940	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SMD_RS05960	COG2259	Doxx family
SMD_RS05990	COG0477	Major facilitator Superfamily
SMD_RS06005	COG1802	Transcriptional regulator
SMD_RS06040	COG3052	prosthetic group binding
SMD_RS06055	COG0579	oxidoreductase
SMD_RS06060	COG0456	acetyltransferase
SMD_RS06060	COG0454	-acetyltransferase
SMD_RS06080	COG3104	oligopeptide transport
SMD_RS06090	COG1297	OPT oligopeptide transporter protein
SMD_RS06095	COG1506	peptidase
SMD_RS06095	COG0823	Involved in the tonB-independent uptake of proteins
SMD_RS06110	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SMD_RS06115	COG2894	cell division
SMD_RS06130	COG4585	Histidine kinase
SMD_RS06135	COG2197	response regulator
SMD_RS06175	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMD_RS06185	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SMD_RS06195	COG1595	DNA-templated transcription, initiation
SMD_RS06205	COG1946	Acyl-CoA thioesterase
SMD_RS06225	COG0824	Thioesterase
SMD_RS06230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMD_RS06235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMD_RS06240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMD_RS06245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMD_RS06250	COG0268	Binds directly to 16S ribosomal RNA
SMD_RS06255	COG0728	peptidoglycan biosynthetic process
SMD_RS06260	COG0196	riboflavin kinase activity
SMD_RS06265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMD_RS06275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMD_RS06300	COG4771	TonB-dependent receptor
SMD_RS06320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMD_RS06360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMD_RS06365	COG1845	cytochrome c oxidase, subunit III
SMD_RS06370	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SMD_RS06385	COG0326	Molecular chaperone. Has ATPase activity
SMD_RS06405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMD_RS06420	COG0228	four-way junction DNA binding
SMD_RS06425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMD_RS06430	COG0336	Belongs to the RNA methyltransferase TrmD family
SMD_RS06435	COG0335	large ribosomal subunit rRNA binding
SMD_RS06455	COG0534	Mate efflux family protein
SMD_RS06475	COG0753	catalase activity
SMD_RS06510	COG0840	transmembrane signaling receptor activity
SMD_RS06515	COG3134	Outer membrane lipoprotein
SMD_RS06530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS06550	COG0024	Methionine aminopeptidase
SMD_RS06575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMD_RS06590	COG2076	Multidrug Resistance protein
SMD_RS06600	COG1647	Serine aminopeptidase, S33
SMD_RS06625	COG2814	Major facilitator Superfamily
SMD_RS06630	COG3706	GGDEF domain
SMD_RS06650	COG0588	phosphoglycerate mutase activity
SMD_RS06660	COG3590	peptidase
SMD_RS06670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMD_RS06680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SMD_RS06685	COG0745	RESPONSE REGULATOR receiver
SMD_RS06690	COG2205	protein histidine kinase activity
SMD_RS06695	COG4452	Inner membrane protein CreD
SMD_RS06710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMD_RS06715	COG0735	belongs to the Fur family
SMD_RS06755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD_RS06795	COG5002	protein histidine kinase activity
SMD_RS06795	COG5001	Diguanylate cyclase
SMD_RS06805	COG1187	pseudouridine synthase activity
SMD_RS06815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMD_RS06840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMD_RS06845	COG1132	(ABC) transporter
SMD_RS06910	COG1695	Transcriptional regulator
SMD_RS06930	COG1981	membrane
SMD_RS06935	COG0825	malonyl-CoA metabolic process
SMD_RS06955	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMD_RS06960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMD_RS06970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMD_RS06975	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD_RS06980	COG0750	zinc metalloprotease
SMD_RS06985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMD_RS06990	COG0575	Belongs to the CDS family
SMD_RS06995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMD_RS07000	COG0233	cytoplasmic translational termination
SMD_RS07005	COG0528	UMP kinase activity
SMD_RS07015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMD_RS07020	COG0052	Belongs to the universal ribosomal protein uS2 family
SMD_RS07040	COG3188	usher protein
SMD_RS07060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SMD_RS07075	COG1393	Belongs to the ArsC family
SMD_RS07080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD_RS07090	COG0367	asparagine synthase
SMD_RS07095	COG0475	glutathione-regulated potassium exporter activity
SMD_RS07130	COG1566	PFAM secretion protein HlyD family protein
SMD_RS07135	COG2814	Major facilitator Superfamily
SMD_RS07145	COG0583	DNA-binding transcription factor activity
SMD_RS07165	COG0557	exoribonuclease II activity
SMD_RS07175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMD_RS07180	COG1538	Outer membrane efflux protein
SMD_RS07185	COG0577	efflux transmembrane transporter activity
SMD_RS07185	COG1136	(ABC) transporter
SMD_RS07190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS07205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMD_RS07210	COG2259	Doxx family
SMD_RS07220	COG3220	belongs to the UPF0276 family
SMD_RS07230	COG0704	Plays a role in the regulation of phosphate uptake
SMD_RS07240	COG0581	inorganic phosphate transmembrane transporter activity
SMD_RS07245	COG0573	inorganic phosphate transmembrane transporter activity
SMD_RS07250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMD_RS07255	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMD_RS07265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMD_RS07275	COG1024	Enoyl-CoA hydratase
SMD_RS07285	COG0494	nUDIX hydrolase
SMD_RS07305	COG0116	Belongs to the methyltransferase superfamily
SMD_RS07305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMD_RS07325	COG2733	membrane
SMD_RS07335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMD_RS07340	COG1012	belongs to the aldehyde dehydrogenase family
SMD_RS07345	COG0477	Major facilitator Superfamily
SMD_RS07350	COG2703	oxygen carrier activity
SMD_RS07375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMD_RS07380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMD_RS07385	COG0174	glutamine synthetase
SMD_RS07395	COG3842	ATPase activity
SMD_RS07400	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMD_RS07405	COG1177	transmembrane transport
SMD_RS07410	COG1012	belongs to the aldehyde dehydrogenase family
SMD_RS07425	COG4535	Mg2 and Co2 transporter CorC
SMD_RS07440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMD_RS07445	COG1702	phosphate starvation-inducible protein PhoH
SMD_RS07455	COG1131	(ABC) transporter
SMD_RS07460	COG0842	Transport permease protein
SMD_RS07465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMD_RS07480	COG0741	lytic transglycosylase activity
SMD_RS07485	COG0723	plastoquinol--plastocyanin reductase activity
SMD_RS07490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMD_RS07495	COG2857	Cytochrome c1
SMD_RS07500	COG0625	glutathione transferase activity
SMD_RS07505	COG2969	positive regulation of protein catabolic process
SMD_RS07540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD_RS07550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SMD_RS07565	COG1611	Belongs to the LOG family
SMD_RS07610	COG0556	nucleotide-excision repair
SMD_RS07635	COG3713	MltA-interacting MipA family protein
SMD_RS07640	COG0745	RESPONSE REGULATOR receiver
SMD_RS07650	COG0658	competence protein
SMD_RS07650	COG2333	competence protein COMEC
SMD_RS07655	COG0811	peptide transport
SMD_RS07670	COG1663	tetraacyldisaccharide 4'-kinase activity
SMD_RS07675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMD_RS07680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMD_RS07690	COG0322	excinuclease ABC activity
SMD_RS07735	COG2801	Transposase and inactivated derivatives
SMD_RS07740	COG2963	transposase activity
SMD_RS07760	COG0583	DNA-binding transcription factor activity
SMD_RS07780	COG2217	Heavy metal translocating P-type atpase
SMD_RS07800	COG2132	Multicopper oxidase
SMD_RS07805	COG0745	RESPONSE REGULATOR receiver
SMD_RS07810	COG5002	protein histidine kinase activity
SMD_RS07815	COG0640	Transcriptional regulator
SMD_RS07830	COG0798	PFAM Bile acid sodium symporter
SMD_RS07840	COG1695	Transcriptional regulator
SMD_RS07915	COG2003	Belongs to the UPF0758 family
SMD_RS07970	COG3311	Transcriptional regulator
SMD_RS07975	COG1569	PIN domain
SMD_RS07980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMD_RS08135	COG0789	Transcriptional regulator
SMD_RS08175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMD_RS08185	COG0789	Transcriptional regulator
SMD_RS08200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMD_RS08205	COG0629	single-stranded DNA binding
SMD_RS08285	COG1136	(ABC) transporter
SMD_RS08285	COG0577	efflux transmembrane transporter activity
SMD_RS08585	COG1397	ADP-ribosylglycohydrolase
SMD_RS08605	COG1917	Cupin 2, conserved barrel domain protein
SMD_RS08605	COG4977	sequence-specific DNA binding
SMD_RS08610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMD_RS08630	COG0348	domain, Protein
SMD_RS08645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMD_RS08660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SMD_RS08665	COG0069	glutamate synthase activity
SMD_RS08670	COG0456	acetyltransferase
SMD_RS08695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD_RS08710	COG1253	flavin adenine dinucleotide binding
SMD_RS08720	COG0306	phosphate transporter
SMD_RS08730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD_RS08745	COG0504	CTP synthase activity
SMD_RS08750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMD_RS08765	COG0148	phosphopyruvate hydratase activity
SMD_RS08770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SMD_RS08775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMD_RS08780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMD_RS08790	COG2840	Smr protein MutS2
SMD_RS08795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMD_RS08800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD_RS08825	COG1534	Rna-binding protein
SMD_RS08830	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SMD_RS08835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMD_RS08845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMD_RS08850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMD_RS08855	COG1923	regulation of RNA biosynthetic process
SMD_RS08860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMD_RS08865	COG1546	Belongs to the CinA family
SMD_RS08870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMD_RS08875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMD_RS08880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMD_RS08885	COG2137	regulation of response to DNA damage stimulus
SMD_RS08890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMD_RS08895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SMD_RS08935	COG3540	Alkaline phosphatase
SMD_RS08950	COG3258	Cytochrome c
SMD_RS08965	COG2223	nitrite transmembrane transporter activity
SMD_RS08975	COG1741	Belongs to the pirin family
SMD_RS08980	COG0583	DNA-binding transcription factor activity
SMD_RS09005	COG0352	thiamine-phosphate diphosphorylase activity
SMD_RS09005	COG0351	phosphomethylpyrimidine kinase
SMD_RS09020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SMD_RS09025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMD_RS09035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMD_RS09045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SMD_RS09050	COG0477	Major facilitator Superfamily
SMD_RS09060	COG0617	tRNA 3'-terminal CCA addition
SMD_RS09065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMD_RS09070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMD_RS09075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMD_RS09080	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMD_RS09085	COG0166	Belongs to the GPI family
SMD_RS09090	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SMD_RS09100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMD_RS09105	COG0671	phosphoesterase, PA-phosphatase related
SMD_RS09115	COG0800	Aldolase
SMD_RS09120	COG0129	dihydroxy-acid dehydratase activity
SMD_RS09130	COG0837	glucose binding
SMD_RS09135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SMD_RS09150	COG2009	succinate dehydrogenase
SMD_RS09155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SMD_RS09160	COG1053	succinate dehydrogenase
SMD_RS09180	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMD_RS09195	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SMD_RS09200	COG1194	a g-specific adenine glycosylase
SMD_RS09205	COG0552	protein localization to endoplasmic reticulum
SMD_RS09220	COG0742	ribosomal rna small subunit methyltransferase
SMD_RS09225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMD_RS09235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMD_RS09240	COG0405	Gamma-glutamyltransferase
SMD_RS09245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMD_RS09265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMD_RS09285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMD_RS09290	COG0415	Belongs to the DNA photolyase family
SMD_RS09295	COG2885	chlorophyll binding
SMD_RS09300	COG0583	DNA-binding transcription factor activity
SMD_RS09365	COG2124	cytochrome p450
SMD_RS09405	COG2963	transposase activity
SMD_RS09410	COG2801	Transposase and inactivated derivatives
SMD_RS09420	COG0582	viral genome integration into host DNA
SMD_RS09435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMD_RS09450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD_RS09465	COG0583	DNA-binding transcription factor activity
SMD_RS09470	COG0497	DNA recombination
SMD_RS09475	COG1420	regulation of RNA biosynthetic process
SMD_RS09480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMD_RS09485	COG0443	Heat shock 70 kDa protein
SMD_RS09490	COG0484	heat shock protein binding
SMD_RS09495	COG2207	Transcriptional regulator
SMD_RS09500	COG2223	nitrite transmembrane transporter activity
SMD_RS09510	COG0287	Prephenate dehydrogenase
SMD_RS09510	COG1605	Chorismate mutase
SMD_RS09520	COG1132	(ABC) transporter
SMD_RS09540	COG5001	Diguanylate cyclase
SMD_RS09550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMD_RS09555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMD_RS09560	COG0343	queuine tRNA-ribosyltransferase activity
SMD_RS09565	COG1862	Preprotein translocase
SMD_RS09575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMD_RS09580	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMD_RS09590	COG2081	HI0933 family
SMD_RS09595	COG4681	YaeQ
SMD_RS09600	COG0564	pseudouridine synthase activity
SMD_RS09610	COG1278	Cold shock
SMD_RS09615	COG0625	glutathione transferase activity
SMD_RS09620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SMD_RS09625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMD_RS09630	COG0513	Belongs to the DEAD box helicase family
SMD_RS09640	COG0583	DNA-binding transcription factor activity
SMD_RS09645	COG0488	(ABC) transporter
SMD_RS09670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS09685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMD_RS09690	COG2957	Belongs to the agmatine deiminase family
SMD_RS09700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMD_RS09705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMD_RS09715	COG0776	regulation of translation
SMD_RS09725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SMD_RS09740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMD_RS09745	COG0183	Belongs to the thiolase family
SMD_RS09750	COG1024	Enoyl-CoA hydratase
SMD_RS09750	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMD_RS09760	COG0105	UTP biosynthetic process
SMD_RS09765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMD_RS09775	COG1426	Protein conserved in bacteria
SMD_RS09775	COG1426	Protein conserved in bacteria
SMD_RS09780	COG2976	Protein conserved in bacteria
SMD_RS09785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD_RS09790	COG1160	GTP binding
SMD_RS09795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMD_RS09800	COG0475	glutathione-regulated potassium exporter activity
SMD_RS09800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMD_RS09820	COG0519	Catalyzes the synthesis of GMP from XMP
SMD_RS09820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMD_RS09825	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SMD_RS09830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SMD_RS09855	COG0583	DNA-binding transcription factor activity
SMD_RS09890	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS09905	COG0596	Alpha beta hydrolase
SMD_RS09920	COG0640	Transcriptional regulator
SMD_RS09945	COG4716	Myosin-crossreactive antigen
SMD_RS09950	COG0300	oxidoreductase activity
SMD_RS09955	COG2207	Transcriptional regulator
SMD_RS09985	COG4206	TonB-dependent receptor
SMD_RS09990	COG0431	NADPH-dependent FMN reductase
SMD_RS10000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD_RS10005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD_RS10010	COG1473	amidohydrolase
SMD_RS10020	COG0765	amino acid transport
SMD_RS10025	COG1126	abc transporter atp-binding protein
SMD_RS10030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMD_RS10050	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SMD_RS10080	COG1309	transcriptional regulator
SMD_RS10095	COG0697	spore germination
SMD_RS10100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMD_RS10105	COG0167	dihydroorotate dehydrogenase activity
SMD_RS10120	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS10125	COG1012	belongs to the aldehyde dehydrogenase family
SMD_RS10160	COG4191	Histidine kinase
SMD_RS10160	COG0784	Response regulator, receiver
SMD_RS10165	COG4999	Histidine kinase
SMD_RS10165	COG3437	response regulator, receiver
SMD_RS10165	COG2205	protein histidine kinase activity
SMD_RS10165	COG3850	Histidine kinase
SMD_RS10170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMD_RS10180	COG0745	RESPONSE REGULATOR receiver
SMD_RS10190	COG0640	Transcriptional regulator
SMD_RS10225	COG0460	homoserine dehydrogenase
SMD_RS10225	COG0527	aspartate kinase activity
SMD_RS10235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMD_RS10240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD_RS10245	COG0124	histidyl-tRNA synthetase
SMD_RS10260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMD_RS10265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMD_RS10270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD_RS10275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMD_RS10275	COG0131	Imidazoleglycerol-phosphate dehydratase
SMD_RS10280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMD_RS10285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMD_RS10290	COG0107	imidazoleglycerol-phosphate synthase activity
SMD_RS10295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMD_RS10295	COG0140	phosphoribosyl-ATP diphosphatase activity
SMD_RS10315	COG1446	asparaginase
SMD_RS10320	COG3142	Participates in the control of copper homeostasis
SMD_RS10335	COG0789	Transcriptional regulator
SMD_RS10350	COG3537	Alpha-1,2-mannosidase
SMD_RS10355	COG1609	Transcriptional regulator
SMD_RS10365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD_RS10380	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SMD_RS10385	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SMD_RS10390	COG0235	Class ii aldolase
SMD_RS10395	COG0531	amino acid
SMD_RS10400	COG0531	amino acid
SMD_RS10410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMD_RS10415	COG0277	FAD linked oxidase domain protein
SMD_RS10430	COG2205	protein histidine kinase activity
SMD_RS10435	COG0745	RESPONSE REGULATOR receiver
SMD_RS10440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS10445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS10460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMD_RS10505	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMD_RS10520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMD_RS10525	COG0505	Belongs to the CarA family
SMD_RS10530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMD_RS10535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMD_RS10550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMD_RS10555	COG4676	Protein conserved in bacteria
SMD_RS10565	COG3279	Response regulator of the LytR AlgR family
SMD_RS10570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMD_RS10580	COG1012	belongs to the aldehyde dehydrogenase family
SMD_RS10600	COG2198	Histidine kinase
SMD_RS10600	COG2205	protein histidine kinase activity
SMD_RS10600	COG0784	Response regulator, receiver
SMD_RS10605	COG1024	Enoyl-CoA hydratase
SMD_RS10610	COG0318	PFAM AMP-dependent synthetase and ligase
SMD_RS10615	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMD_RS10620	COG1012	belongs to the aldehyde dehydrogenase family
SMD_RS10625	COG1309	transcriptional regulator
SMD_RS10630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMD_RS10665	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SMD_RS10675	COG0840	transmembrane signaling receptor activity
SMD_RS10680	COG0840	transmembrane signaling receptor activity
SMD_RS10690	COG0835	chemotaxis
SMD_RS10695	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SMD_RS10700	COG0840	transmembrane signaling receptor activity
SMD_RS10710	COG0745	RESPONSE REGULATOR receiver
SMD_RS10720	COG0835	chemotaxis
SMD_RS10730	COG1360	Flagellar Motor Protein
SMD_RS10735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SMD_RS10740	COG0643	Histidine kinase
SMD_RS10740	COG2198	Histidine kinase
SMD_RS10740	COG0784	Response regulator, receiver
SMD_RS10745	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SMD_RS10770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMD_RS10775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMD_RS10790	COG1987	bacterial-type flagellum assembly
SMD_RS10800	COG3190	flagellar
SMD_RS10850	COG1677	Flagellar hook-basal body complex protein FliE
SMD_RS10875	COG2197	response regulator
SMD_RS10895	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SMD_RS10920	COG1256	bacterial-type flagellum assembly
SMD_RS10935	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SMD_RS10945	COG4787	bacterial-type flagellum-dependent cell motility
SMD_RS10965	COG1815	bacterial-type flagellum-dependent cell motility
SMD_RS10970	COG0784	Response regulator, receiver
SMD_RS10970	COG0835	chemotaxis
SMD_RS10990	COG5002	protein histidine kinase activity
SMD_RS11025	COG2915	High frequency lysogenization protein hflD homolog
SMD_RS11030	COG0482	sulfurtransferase activity
SMD_RS11045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMD_RS11055	COG0542	response to heat
SMD_RS11085	COG0492	ferredoxin-NADP+ reductase activity
SMD_RS11090	COG1674	ftsk spoiiie
SMD_RS11105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMD_RS11110	COG3152	Membrane
SMD_RS11120	COG2819	hydrolase of the alpha beta superfamily
SMD_RS11130	COG4558	Periplasmic binding protein
SMD_RS11135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMD_RS11140	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMD_RS11150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMD_RS11165	COG0784	Response regulator, receiver
SMD_RS11165	COG5002	protein histidine kinase activity
SMD_RS11185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS11190	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS11265	COG4644	lycopene metabolic process
SMD_RS11305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMD_RS11315	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SMD_RS11330	COG1595	DNA-templated transcription, initiation
SMD_RS11340	COG0702	epimerase
SMD_RS11350	COG0784	Response regulator, receiver
SMD_RS11355	COG4251	negative regulation of phosphorylation
SMD_RS11365	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SMD_RS11380	COG2205	protein histidine kinase activity
SMD_RS11455	COG2815	serine threonine protein kinase
SMD_RS11455	COG0515	serine threonine protein kinase
SMD_RS11470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMD_RS11490	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMD_RS11495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMD_RS11500	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMD_RS11505	COG2080	2 iron, 2 sulfur cluster binding
SMD_RS11520	COG1309	transcriptional regulator
SMD_RS11535	COG4977	sequence-specific DNA binding
SMD_RS11540	COG4221	oxidoreductase activity
SMD_RS11580	COG3685	Protein conserved in bacteria
SMD_RS11605	COG3546	catalase activity
SMD_RS11610	COG3685	Protein conserved in bacteria
SMD_RS11640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMD_RS11660	COG1063	alcohol dehydrogenase
SMD_RS11690	COG1609	Transcriptional regulator
SMD_RS11695	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMD_RS11695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMD_RS11700	COG1105	Belongs to the carbohydrate kinase PfkB family
SMD_RS11705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD_RS11705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMD_RS11725	COG2211	Major facilitator Superfamily
SMD_RS11730	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD_RS11745	COG3661	Belongs to the glycosyl hydrolase 67 family
SMD_RS11755	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD_RS11760	COG0477	Major facilitator Superfamily
SMD_RS11770	COG1070	Carbohydrate kinase
SMD_RS11815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SMD_RS11830	COG2828	Protein conserved in bacteria
SMD_RS11835	COG0583	DNA-binding transcription factor activity
SMD_RS11860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMD_RS11865	COG0583	DNA-binding transcription factor activity
SMD_RS11935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMD_RS11955	COG0583	DNA-binding transcription factor activity
SMD_RS11980	COG2204	response regulator
SMD_RS12110	COG0708	Exodeoxyribonuclease III
SMD_RS12115	COG0366	Alpha amylase catalytic
SMD_RS12120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS12140	COG0577	efflux transmembrane transporter activity
SMD_RS12140	COG1136	(ABC) transporter
SMD_RS12145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS12155	COG0745	RESPONSE REGULATOR receiver
SMD_RS12160	COG2205	protein histidine kinase activity
SMD_RS12170	COG3214	Protein conserved in bacteria
SMD_RS12180	COG4774	siderophore transport
SMD_RS12230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMD_RS12235	COG1285	pathogenesis
SMD_RS12240	COG4191	Histidine kinase
SMD_RS12245	COG4566	intracellular signal transduction
SMD_RS12305	COG0243	molybdopterin cofactor binding
SMD_RS12330	COG0477	Major facilitator Superfamily
SMD_RS12355	COG1136	(ABC) transporter
SMD_RS12370	COG0583	DNA-binding transcription factor activity
SMD_RS12375	COG0656	L-ascorbic acid biosynthetic process
SMD_RS12410	COG5002	protein histidine kinase activity
SMD_RS12415	COG0583	DNA-binding transcription factor activity
SMD_RS12420	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS12445	COG0642	Histidine kinase
SMD_RS12450	COG3537	Alpha-1,2-mannosidase
SMD_RS12470	COG0477	Major facilitator Superfamily
SMD_RS12485	COG3920	Histidine kinase
SMD_RS12530	COG1335	isochorismatase
SMD_RS12560	COG0811	peptide transport
SMD_RS12695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMD_RS12700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMD_RS12710	COG0840	transmembrane signaling receptor activity
SMD_RS12720	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SMD_RS12725	COG4149	molybdate abc transporter
SMD_RS12730	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMD_RS12735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD_RS12745	COG0746	molybdenum cofactor guanylyltransferase activity
SMD_RS12750	COG0314	molybdopterin synthase activity
SMD_RS12760	COG0303	'Molybdopterin
SMD_RS12765	COG0315	cyclic pyranopterin monophosphate synthase activity
SMD_RS12765	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMD_RS12770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMD_RS12820	COG2207	Transcriptional regulator
SMD_RS12835	COG1566	PFAM secretion protein HlyD family protein
SMD_RS12875	COG2205	protein histidine kinase activity
SMD_RS12885	COG2194	sulfuric ester hydrolase activity
SMD_RS12905	COG2885	chlorophyll binding
SMD_RS12915	COG1943	Transposase
SMD_RS12920	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS12925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMD_RS12925	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SMD_RS12935	COG3433	isochorismatase activity
SMD_RS12935	COG1535	isochorismatase
SMD_RS12940	COG1021	2,3-dihydroxybenzoate-AMP ligase
SMD_RS12955	COG2409	Drug exporters of the RND superfamily
SMD_RS12960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMD_RS13005	COG4771	TonB-dependent receptor
SMD_RS13020	COG1914	H( )-stimulated, divalent metal cation uptake system
SMD_RS13035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD_RS13040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMD_RS13055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMD_RS13075	COG0583	DNA-binding transcription factor activity
SMD_RS13085	COG4772	TonB-dependent receptor
SMD_RS13105	COG2226	methyltransferase
SMD_RS13150	COG4964	Belongs to the GSP D family
SMD_RS13205	COG2814	Major facilitator Superfamily
SMD_RS13215	COG1228	amidohydrolase
SMD_RS13225	COG1335	isochorismatase
SMD_RS13240	COG3850	Histidine kinase
SMD_RS13245	COG2197	response regulator
SMD_RS13250	COG2814	Major facilitator Superfamily
SMD_RS13260	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SMD_RS13270	COG0583	DNA-binding transcription factor activity
SMD_RS13285	COG3161	chorismate lyase activity
SMD_RS13320	COG0277	FAD linked oxidase domain protein
SMD_RS13325	COG1304	FMN binding
SMD_RS13330	COG2186	Transcriptional regulator
SMD_RS13340	COG1285	pathogenesis
SMD_RS13365	COG2814	Major facilitator Superfamily
SMD_RS13420	COG0587	DNA-directed DNA polymerase activity
SMD_RS13435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMD_RS13440	COG0519	Catalyzes the synthesis of GMP from XMP
SMD_RS13440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMD_RS13455	COG1595	DNA-templated transcription, initiation
SMD_RS13465	COG4206	TonB-dependent receptor
SMD_RS13465	COG1629	transport
SMD_RS13495	COG0531	amino acid
SMD_RS13510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMD_RS13595	COG5001	Diguanylate cyclase
SMD_RS13595	COG3447	MASE1 domain protein
SMD_RS13595	COG5002	protein histidine kinase activity
SMD_RS13600	COG2183	response to ionizing radiation
SMD_RS13615	COG1983	PspC domain protein
SMD_RS13625	COG3243	poly(R)-hydroxyalkanoic acid synthase
SMD_RS13640	COG0534	Mate efflux family protein
SMD_RS13660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SMD_RS13670	COG0668	transmembrane transport
SMD_RS13675	COG1902	pentaerythritol trinitrate reductase activity
SMD_RS13685	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SMD_RS13695	COG1733	regulation of RNA biosynthetic process
SMD_RS13705	COG0456	acetyltransferase
SMD_RS13785	COG2948	multi-organism process
SMD_RS13795	COG3736	Type IV secretory pathway, component VirB8
SMD_RS13820	COG2814	Major facilitator Superfamily
SMD_RS13860	COG4191	Histidine kinase
SMD_RS13860	COG0784	Response regulator, receiver
SMD_RS13875	COG4774	siderophore transport
SMD_RS13900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS13905	COG1136	(ABC) transporter
SMD_RS13905	COG0577	efflux transmembrane transporter activity
SMD_RS13945	COG1733	regulation of RNA biosynthetic process
SMD_RS13950	COG0604	alcohol dehydrogenase
SMD_RS13955	COG0210	DNA helicase
SMD_RS13970	COG0583	DNA-binding transcription factor activity
SMD_RS13975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMD_RS13985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMD_RS14000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMD_RS14005	COG0077	Prephenate dehydratase
SMD_RS14005	COG1605	Chorismate mutase
SMD_RS14010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMD_RS14050	COG1228	amidohydrolase
SMD_RS14065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SMD_RS14185	COG4993	Dehydrogenase
SMD_RS14195	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMD_RS14205	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SMD_RS14215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMD_RS14220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMD_RS14235	COG0359	binds to the 23S rRNA
SMD_RS14240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMD_RS14245	COG0360	Binds together with S18 to 16S ribosomal RNA
SMD_RS14255	COG0316	Belongs to the HesB IscA family
SMD_RS14260	COG0017	Asparaginyl-tRNA synthetase
SMD_RS14280	COG0288	reversible hydration of carbon dioxide
SMD_RS14290	COG3844	kynureninase activity
SMD_RS14295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD_RS14300	COG2925	Exonuclease
SMD_RS14310	COG0667	Aldo Keto reductase
SMD_RS14330	COG2902	Dehydrogenase
SMD_RS14340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS14345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS14355	COG1960	acyl-CoA dehydrogenase activity
SMD_RS14370	COG0646	methionine synthase
SMD_RS14370	COG1410	methionine synthase
SMD_RS14380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SMD_RS14380	COG2755	lipolytic protein G-D-S-L family
SMD_RS14390	COG2900	Belongs to the SlyX family
SMD_RS14405	COG0386	Belongs to the glutathione peroxidase family
SMD_RS14415	COG1725	Transcriptional regulator
SMD_RS14420	COG1131	(ABC) transporter
SMD_RS14455	COG2850	peptidyl-arginine hydroxylation
SMD_RS14465	COG0567	Dehydrogenase, E1 component
SMD_RS14490	COG3540	Alkaline phosphatase
SMD_RS14500	COG0305	Participates in initiation and elongation during chromosome replication
SMD_RS14510	COG0367	asparagine synthase
SMD_RS14520	COG0625	glutathione transferase activity
SMD_RS14540	COG0084	hydrolase, TatD family'
SMD_RS14545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMD_RS14575	COG1393	Belongs to the ArsC family
SMD_RS14580	COG0625	glutathione transferase activity
SMD_RS14595	COG1595	DNA-templated transcription, initiation
SMD_RS14600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMD_RS14615	COG0386	Belongs to the glutathione peroxidase family
SMD_RS14620	COG0339	signal peptide processing
SMD_RS14625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMD_RS14645	COG0705	Rhomboid family
SMD_RS14650	COG3104	oligopeptide transport
SMD_RS14660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMD_RS14665	COG4290	ribonuclease
SMD_RS14680	COG0316	Belongs to the HesB IscA family
SMD_RS14680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SMD_RS14685	COG2154	pterin-4-alpha-carbinolamine dehydratase
SMD_RS14695	COG0428	transporter
SMD_RS14705	COG1530	ribonuclease E activity
SMD_RS14720	COG0395	ABC-type sugar transport system, permease component
SMD_RS14750	COG0271	Belongs to the BolA IbaG family
SMD_RS14755	COG2350	Protein conserved in bacteria
SMD_RS14760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMD_RS14765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMD_RS14770	COG1187	pseudouridine synthase activity
SMD_RS14780	COG2814	Major facilitator Superfamily
SMD_RS14795	COG0436	Aminotransferase
SMD_RS14800	COG4133	protoheme IX ABC transporter activity
SMD_RS14820	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SMD_RS14835	COG4235	cytochrome complex assembly
SMD_RS14835	COG3088	subunit of a heme lyase
SMD_RS14845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMD_RS14855	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SMD_RS14860	COG4988	ABC transporter
SMD_RS14870	COG1294	oxidase, subunit
SMD_RS14900	COG0726	polysaccharide deacetylase
SMD_RS14900	COG1649	PFAM Uncharacterised BCR, COG1649
SMD_RS14905	COG1215	transferase activity, transferring glycosyl groups
SMD_RS14915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMD_RS14930	COG0165	Argininosuccinate lyase
SMD_RS14935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMD_RS14945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMD_RS14950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMD_RS14955	COG0137	argininosuccinate synthase activity
SMD_RS14960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMD_RS14975	COG2166	iron-sulfur cluster assembly
SMD_RS14990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMD_RS15010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD_RS15015	COG0402	S-adenosylhomocysteine deaminase activity
SMD_RS15020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMD_RS15025	COG1509	lysine 2,3-aminomutase activity
SMD_RS15030	COG5001	Diguanylate cyclase
SMD_RS15030	COG3300	MHYT domain
SMD_RS15050	COG0501	Belongs to the peptidase M48B family
SMD_RS15060	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS15080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMD_RS15085	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMD_RS15090	COG0802	atpase or kinase
SMD_RS15095	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMD_RS15095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMD_RS15100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMD_RS15105	COG1570	exodeoxyribonuclease VII activity
SMD_RS15115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMD_RS15125	COG4771	TonB-dependent receptor
SMD_RS15140	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS15145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMD_RS15145	COG2169	Transcriptional regulator
SMD_RS15150	COG2130	NADP-dependent
SMD_RS15175	COG1960	acyl-CoA dehydrogenase activity
SMD_RS15185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMD_RS15200	COG2197	response regulator
SMD_RS15255	COG1309	transcriptional regulator
SMD_RS15260	COG2076	Multidrug Resistance protein
SMD_RS15270	COG1280	lysine exporter protein (LysE YggA)
SMD_RS15275	COG1794	racemase activity, acting on amino acids and derivatives
SMD_RS15315	COG0776	regulation of translation
SMD_RS15320	COG0072	phenylalanine-tRNA ligase activity
SMD_RS15320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD_RS15325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMD_RS15330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMD_RS15335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMD_RS15340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMD_RS15370	COG1185	polyribonucleotide nucleotidyltransferase activity
SMD_RS15375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMD_RS15385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMD_RS15390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMD_RS15395	COG0195	Participates in both transcription termination and antitermination
SMD_RS15400	COG0779	Required for maturation of 30S ribosomal subunits
SMD_RS15415	COG1007	ATP synthesis coupled electron transport
SMD_RS15430	COG0713	ATP synthesis coupled electron transport
SMD_RS15440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD_RS15445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMD_RS15460	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SMD_RS15465	COG0649	NAD binding
SMD_RS15470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD_RS15475	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD_RS15480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMD_RS15495	COG0149	triose-phosphate isomerase activity
SMD_RS15505	COG3119	arylsulfatase activity
SMD_RS15510	COG0438	transferase activity, transferring glycosyl groups
SMD_RS15515	COG0726	polysaccharide deacetylase
SMD_RS15520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMD_RS15525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMD_RS15530	COG0159	tryptophan synthase activity
SMD_RS15540	COG0133	tryptophan synthase activity
SMD_RS15575	COG0135	phosphoribosylanthranilate isomerase activity
SMD_RS15580	COG0101	tRNA pseudouridine synthase activity
SMD_RS15595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMD_RS15600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMD_RS15605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMD_RS15610	COG2890	protein-(glutamine-N5) methyltransferase activity
SMD_RS15615	COG1999	signal sequence binding
SMD_RS15620	COG0688	phosphatidylethanolamine metabolic process
SMD_RS15635	COG0433	COG0433 Predicted ATPase
SMD_RS15640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMD_RS15650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMD_RS15700	COG0412	Dienelactone hydrolase
SMD_RS15715	COG0717	Belongs to the dCTP deaminase family
SMD_RS15720	COG0489	protein tyrosine kinase activity
SMD_RS15725	COG4771	TonB-dependent receptor
SMD_RS15730	COG4206	TonB-dependent receptor
SMD_RS15740	COG3590	peptidase
SMD_RS15770	COG0697	spore germination
SMD_RS15780	COG2311	Membrane
SMD_RS15785	COG1047	Peptidyl-prolyl cis-trans
SMD_RS15790	COG0791	NLP P60 protein
SMD_RS15795	COG0791	NLP P60 protein
SMD_RS15800	COG1301	dicarboxylic acid transport
SMD_RS15820	COG1722	exodeoxyribonuclease VII activity
SMD_RS15825	COG0142	geranyltranstransferase activity
SMD_RS15835	COG0312	modulator of DNA gyrase
SMD_RS15840	COG3028	Belongs to the UPF0307 family
SMD_RS15845	COG0312	modulator of DNA gyrase
SMD_RS15865	COG2968	Membrane
SMD_RS15895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMD_RS15905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMD_RS15920	COG0495	leucyl-tRNA aminoacylation
SMD_RS15930	COG3118	belongs to the thioredoxin family
SMD_RS15965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SMD_RS15975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMD_RS15980	COG0346	lactoylglutathione lyase activity
SMD_RS15990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD_RS15990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMD_RS16000	COG2878	Part of a membrane complex involved in electron transport
SMD_RS16005	COG0251	oxidation-reduction process
SMD_RS16010	COG0392	lysyltransferase activity
SMD_RS16010	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMD_RS16040	COG2824	Alkylphosphonate utilization operon protein PhnA
SMD_RS16045	COG1077	Cell shape determining protein MreB Mrl
SMD_RS16085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SMD_RS16090	COG3122	Protein conserved in bacteria
SMD_RS16095	COG1451	nucleotide metabolic process
SMD_RS16105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMD_RS16125	COG0183	Belongs to the thiolase family
SMD_RS16140	COG1960	acyl-CoA dehydrogenase activity
SMD_RS16150	COG1793	dna ligase
SMD_RS16155	COG1201	RNA secondary structure unwinding
SMD_RS16170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMD_RS16175	COG1278	Cold shock
SMD_RS16180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMD_RS16185	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SMD_RS16190	COG1472	Belongs to the glycosyl hydrolase 3 family
SMD_RS16195	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMD_RS16200	COG2954	triphosphatase activity
SMD_RS16205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMD_RS16210	COG0745	RESPONSE REGULATOR receiver
SMD_RS16215	COG1381	Involved in DNA repair and RecF pathway recombination
SMD_RS16220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMD_RS16235	COG0681	Belongs to the peptidase S26 family
SMD_RS16240	COG0481	GTPase activity
SMD_RS16245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMD_RS16265	COG1741	Belongs to the pirin family
SMD_RS16270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMD_RS16280	COG1741	Belongs to the pirin family
SMD_RS16285	COG1966	Carbon starvation protein
SMD_RS16290	COG2879	small protein
SMD_RS16305	COG2205	protein histidine kinase activity
SMD_RS16310	COG0745	RESPONSE REGULATOR receiver
SMD_RS16345	COG2814	Major facilitator Superfamily
SMD_RS16350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMD_RS16350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMD_RS16360	COG1113	amino acid transport
SMD_RS16365	COG2207	Transcriptional regulator
SMD_RS16365	COG1917	Cupin 2, conserved barrel domain protein
SMD_RS16370	COG0753	catalase activity
SMD_RS16395	COG1376	ErfK ybiS ycfS ynhG family protein
SMD_RS16400	COG0739	heme binding
SMD_RS16410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMD_RS16420	COG0330	HflC and HflK could
SMD_RS16425	COG0330	HflC and HflK could
SMD_RS16430	COG0604	alcohol dehydrogenase
SMD_RS16445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMD_RS16445	COG0678	peroxiredoxin activity
SMD_RS16455	COG4953	penicillin-binding protein 1C
SMD_RS16460	COG2373	Large extracellular alpha-helical protein
SMD_RS16465	COG2079	MmgE PrpD family protein
SMD_RS16470	COG2828	Protein conserved in bacteria
SMD_RS16480	COG3609	addiction module antidote protein, CC2985 family
SMD_RS16500	COG3829	transcription factor binding
SMD_RS16510	COG0259	pyridoxamine-phosphate oxidase activity
SMD_RS16525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMD_RS16545	COG0477	Major facilitator Superfamily
SMD_RS16565	COG3038	cytochrome b561
SMD_RS16580	COG1760	l-serine dehydratase
SMD_RS16590	COG0460	homoserine dehydrogenase
SMD_RS16590	COG0527	aspartate kinase activity
SMD_RS16595	COG0626	cystathionine gamma-synthase activity
SMD_RS16600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMD_RS16605	COG0739	heme binding
SMD_RS16610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMD_RS16615	COG1272	protein, Hemolysin III
SMD_RS16630	COG0463	Glycosyl transferase, family 2
SMD_RS16640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMD_RS16655	COG1309	transcriptional regulator
SMD_RS16700	COG0583	DNA-binding transcription factor activity
SMD_RS16710	COG0509	glycine decarboxylation via glycine cleavage system
SMD_RS16715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMD_RS16725	COG1742	UPF0060 membrane protein
SMD_RS16730	COG3956	TIGRFAM MazG family protein
SMD_RS16735	COG1218	3'(2'),5'-bisphosphate nucleotidase
SMD_RS16740	COG0494	nUDIX hydrolase
SMD_RS16750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMD_RS16765	COG0784	Response regulator, receiver
SMD_RS16765	COG0643	Histidine kinase
SMD_RS16765	COG2198	Histidine kinase
SMD_RS16770	COG0840	transmembrane signaling receptor activity
SMD_RS16775	COG0835	chemotaxis
SMD_RS16790	COG0189	ligase activity
SMD_RS16800	COG1214	PFAM Peptidase M22, glycoprotease
SMD_RS16805	COG1199	ATP-dependent helicase activity
SMD_RS16815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMD_RS16820	COG1216	Glycosyl transferase, family 2
SMD_RS16830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMD_RS16840	COG1643	Atp-dependent helicase
SMD_RS16845	COG0783	Belongs to the Dps family
SMD_RS16850	COG0514	ATP-dependent DNA helicase (RecQ)
SMD_RS16960	COG4695	Portal protein
SMD_RS17170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMD_RS17175	COG0602	queuosine metabolic process
SMD_RS17185	COG2885	chlorophyll binding
SMD_RS17190	COG0823	Involved in the tonB-independent uptake of proteins
SMD_RS17205	COG0811	peptide transport
SMD_RS17210	COG0824	Thioesterase
SMD_RS17215	COG2255	four-way junction helicase activity
SMD_RS17225	COG0632	four-way junction helicase activity
SMD_RS17230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMD_RS17235	COG0217	transcriptional regulatory protein
SMD_RS17255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMD_RS17285	COG0488	(ABC) transporter
SMD_RS17305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMD_RS17305	COG4651	solute:proton antiporter activity
SMD_RS17315	COG0745	RESPONSE REGULATOR receiver
SMD_RS17320	COG2205	protein histidine kinase activity
SMD_RS17335	COG0542	response to heat
SMD_RS17355	COG0028	Belongs to the TPP enzyme family
SMD_RS17380	COG3387	PFAM Glycoside hydrolase 15-related
SMD_RS17385	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SMD_RS17390	COG3011	Protein conserved in bacteria
SMD_RS17405	COG0564	pseudouridine synthase activity
SMD_RS17410	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMD_RS17420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMD_RS17420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMD_RS17430	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD_RS17460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SMD_RS17475	COG2963	transposase activity
SMD_RS17480	COG2801	Transposase and inactivated derivatives
SMD_RS17485	COG2205	protein histidine kinase activity
SMD_RS17490	COG0745	RESPONSE REGULATOR receiver
SMD_RS17510	COG0189	ligase activity
SMD_RS17535	COG4625	pathogenesis
SMD_RS17535	COG3240	lipase activity
SMD_RS17545	COG2022	thiamine diphosphate biosynthetic process
SMD_RS17550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMD_RS17555	COG0471	metal ion transport
SMD_RS17555	COG3273	potassium ion transport
SMD_RS17575	COG1970	mechanosensitive ion channel activity
SMD_RS17585	COG1115	amino acid carrier protein
SMD_RS17595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMD_RS17600	COG1115	amino acid carrier protein
SMD_RS17610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS17615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS17640	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMD_RS17650	COG3588	fructose-bisphosphate aldolase
SMD_RS17655	COG0469	pyruvate kinase activity
SMD_RS17665	COG0126	phosphoglycerate kinase activity
SMD_RS17680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMD_RS17685	COG3047	cAMP biosynthetic process
SMD_RS17725	COG3093	addiction module antidote protein HigA
SMD_RS17735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMD_RS17740	COG1301	dicarboxylic acid transport
SMD_RS17770	COG0714	Associated with various cellular activities
SMD_RS17800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMD_RS17815	COG5295	Hep Hag repeat protein
SMD_RS17850	COG0254	rRNA binding
SMD_RS17860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMD_RS17870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMD_RS17875	COG1758	RNA polymerase activity
SMD_RS17885	COG3383	formate dehydrogenase (NAD+) activity
SMD_RS17885	COG0243	molybdopterin cofactor binding
SMD_RS17890	COG3383	formate dehydrogenase (NAD+) activity
SMD_RS17890	COG0243	molybdopterin cofactor binding
SMD_RS17895	COG0437	4 iron, 4 sulfur cluster binding
SMD_RS17900	COG2864	formate dehydrogenase
SMD_RS17910	COG1921	L-seryl-tRNASec selenium transferase activity
SMD_RS17915	COG3276	selenocysteine insertion sequence binding
SMD_RS17925	COG0709	Synthesizes selenophosphate from selenide and ATP
SMD_RS17930	COG1561	YicC-like family, N-terminal region
SMD_RS17935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SMD_RS17940	COG0346	lactoylglutathione lyase activity
SMD_RS17950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMD_RS17965	COG0006	proline dipeptidase activity
SMD_RS17970	COG0006	proline dipeptidase activity
SMD_RS17975	COG3079	Belongs to the UPF0149 family
SMD_RS17990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMD_RS18000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMD_RS18010	COG2912	Transglutaminase-like superfamily
SMD_RS18015	COG1773	rubredoxin
SMD_RS18025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMD_RS18040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMD_RS18045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD_RS18060	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS18090	COG0671	phosphoesterase, PA-phosphatase related
SMD_RS18100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMD_RS18105	COG0563	adenylate kinase activity
SMD_RS18125	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SMD_RS18135	COG0848	biopolymer transport protein
SMD_RS18145	COG2832	Protein of unknown function (DUF454)
SMD_RS18185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMD_RS18210	COG0745	RESPONSE REGULATOR receiver
SMD_RS18220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMD_RS18230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMD_RS18235	COG0405	Gamma-glutamyltransferase
SMD_RS18240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMD_RS18260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMD_RS18265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMD_RS18280	COG0473	3-isopropylmalate dehydrogenase activity
SMD_RS18295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS18300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS18310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMD_RS18315	COG1538	Outer membrane efflux protein
SMD_RS18320	COG0531	amino acid
SMD_RS18325	COG1519	Transferase
SMD_RS18330	COG1560	Kdo2-lipid A biosynthetic process
SMD_RS18365	COG1301	dicarboxylic acid transport
SMD_RS18375	COG4191	Histidine kinase
SMD_RS18390	COG0642	Histidine kinase
SMD_RS18405	COG2851	Citrate transporter
SMD_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS18425	COG1162	GTPase activity
SMD_RS18430	COG0436	Aminotransferase
SMD_RS18450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SMD_RS18470	COG1228	amidohydrolase
SMD_RS18475	COG0804	urea catabolic process
SMD_RS18485	COG1307	EDD domain protein, DegV family
SMD_RS18525	COG4251	negative regulation of phosphorylation
SMD_RS18525	COG2203	Gaf domain
SMD_RS18525	COG3706	GGDEF domain
SMD_RS18525	COG5001	Diguanylate cyclase
SMD_RS18530	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMD_RS18540	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SMD_RS18555	COG1902	pentaerythritol trinitrate reductase activity
SMD_RS18580	COG0583	DNA-binding transcription factor activity
SMD_RS18585	COG1064	alcohol dehydrogenase
SMD_RS18605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMD_RS18610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMD_RS18620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMD_RS18625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMD_RS18640	COG1522	sequence-specific DNA binding
SMD_RS18650	COG4773	Receptor
SMD_RS18675	COG0617	tRNA 3'-terminal CCA addition
SMD_RS18705	COG3468	outer membrane autotransporter barrel domain protein
SMD_RS18715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMD_RS18720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD_RS18725	COG1609	Transcriptional regulator
SMD_RS18735	COG0837	glucose binding
SMD_RS18745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMD_RS18765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMD_RS18775	COG4191	Histidine kinase
SMD_RS18780	COG0784	Response regulator, receiver
SMD_RS18785	COG4251	negative regulation of phosphorylation
SMD_RS18790	COG2823	Periplasmic or secreted lipoprotein
SMD_RS18795	COG0673	inositol 2-dehydrogenase activity
SMD_RS18800	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SMD_RS18820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SMD_RS18825	COG0321	lipoyl(octanoyl) transferase activity
SMD_RS18830	COG2921	Belongs to the UPF0250 family
SMD_RS18840	COG1686	Belongs to the peptidase S11 family
SMD_RS18845	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMD_RS18850	COG2951	lytic endotransglycosylase activity
SMD_RS18855	COG0772	Belongs to the SEDS family
SMD_RS18860	COG0772	Belongs to the SEDS family
SMD_RS18875	COG1792	Involved in formation and maintenance of cell shape
SMD_RS18880	COG1077	Cell shape determining protein MreB Mrl
SMD_RS18885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMD_RS18900	COG0308	aminopeptidase N
SMD_RS18905	COG2226	methyltransferase
SMD_RS18935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS18940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS18950	COG0673	inositol 2-dehydrogenase activity
SMD_RS18960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMD_RS18975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMD_RS18985	COG2832	Protein of unknown function (DUF454)
SMD_RS18995	COG0436	Aminotransferase
SMD_RS19000	COG1505	serine-type exopeptidase activity
SMD_RS19025	COG0697	spore germination
SMD_RS19030	COG1666	GTP binding
SMD_RS19045	COG0339	signal peptide processing
SMD_RS19055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMD_RS19070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMD_RS19070	COG0517	IMP dehydrogenase activity
SMD_RS19075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMD_RS19085	COG1136	(ABC) transporter
SMD_RS19110	COG4191	Histidine kinase
SMD_RS19120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMD_RS19135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMD_RS19140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMD_RS19145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMD_RS19150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMD_RS19155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMD_RS19160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMD_RS19170	COG0356	it plays a direct role in the translocation of protons across the membrane
SMD_RS19185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMD_RS19210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMD_RS19235	COG0181	hydroxymethylbilane synthase activity
SMD_RS19245	COG2972	Histidine kinase
SMD_RS19245	COG0745	RESPONSE REGULATOR receiver
SMD_RS19250	COG0400	carboxylic ester hydrolase activity
SMD_RS19260	COG4771	TonB-dependent receptor
SMD_RS19270	COG0840	transmembrane signaling receptor activity
SMD_RS19330	COG1136	(ABC) transporter
SMD_RS19335	COG0577	efflux transmembrane transporter activity
SMD_RS19335	COG1136	(ABC) transporter
SMD_RS19340	COG0577	efflux transmembrane transporter activity
SMD_RS19340	COG1136	(ABC) transporter
SMD_RS19345	COG1132	(ABC) transporter
SMD_RS19405	COG2259	Doxx family
SMD_RS19415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SMD_RS19545	COG2801	Transposase and inactivated derivatives
SMD_RS19550	COG2963	transposase activity
SMD_RS19570	COG0582	viral genome integration into host DNA
SMD_RS19585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMD_RS19590	COG1490	D-aminoacyl-tRNA deacylase activity
SMD_RS19600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMD_RS19635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMD_RS19635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMD_RS19640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMD_RS19645	COG0242	peptide deformylase activity
SMD_RS19655	COG0758	DNA mediated transformation
SMD_RS19660	COG2922	Belongs to the Smg family
SMD_RS19670	COG1714	RDD family
SMD_RS19675	COG1754	DNA topoisomerase type I activity
SMD_RS19675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMD_RS19680	COG0009	L-threonylcarbamoyladenylate synthase
SMD_RS19695	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS19705	COG0616	signal peptide processing
SMD_RS19710	COG0534	Mate efflux family protein
SMD_RS19725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMD_RS19730	COG0625	glutathione transferase activity
SMD_RS19740	COG1252	NADH dehydrogenase
SMD_RS19760	COG2860	membrane
SMD_RS19765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMD_RS19785	COG1846	Transcriptional regulator
SMD_RS19815	COG0459	protein refolding
SMD_RS19820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMD_RS19825	COG2356	endonuclease I
SMD_RS19830	COG1324	tolerance protein
SMD_RS19840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMD_RS19850	COG0840	transmembrane signaling receptor activity
SMD_RS19870	COG0583	DNA-binding transcription factor activity
SMD_RS19880	COG1686	Belongs to the peptidase S11 family
SMD_RS19890	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMD_RS19900	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMD_RS19910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMD_RS19920	COG0511	ligase activity, forming carbon-carbon bonds
SMD_RS19925	COG0439	Biotin carboxylase
SMD_RS19940	COG2264	protein methyltransferase activity
SMD_RS19950	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
SMD_RS19955	COG4589	Belongs to the CDS family
SMD_RS19960	COG0204	Acyl-transferase
SMD_RS19970	COG2453	phosphatase
SMD_RS19970	COG0671	phosphoesterase, PA-phosphatase related
SMD_RS19975	COG2267	carboxylic ester hydrolase activity
SMD_RS19980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMD_RS19985	COG0138	bifunctional purine biosynthesis protein purh
SMD_RS19990	COG0151	Belongs to the GarS family
SMD_RS20005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMD_RS20010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMD_RS20015	COG2201	protein-glutamate methylesterase activity
SMD_RS20020	COG2177	Part of the ABC transporter FtsEX involved in
SMD_RS20025	COG2884	Cell division ATP-binding protein ftsE
SMD_RS20035	COG3118	belongs to the thioredoxin family
SMD_RS20045	COG3706	GGDEF domain
SMD_RS20055	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
SMD_RS20095	COG1652	LysM domain
SMD_RS20100	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMD_RS20100	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMD_RS20105	COG1473	amidohydrolase
SMD_RS20110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS20115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS20120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS20125	COG1289	transmembrane transporter activity
SMD_RS20130	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS20135	COG2814	Major facilitator Superfamily
SMD_RS20165	COG0316	Belongs to the HesB IscA family
SMD_RS20205	COG1051	belongs to the nudix hydrolase family
SMD_RS20220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMD_RS20225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMD_RS20230	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SMD_RS20240	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SMD_RS20245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMD_RS20250	COG0730	response to heat
SMD_RS20260	COG0134	indole-3-glycerol-phosphate synthase activity
SMD_RS20265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMD_RS20285	COG1597	lipid kinase activity
SMD_RS20300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMD_RS20305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMD_RS20315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMD_RS20315	COG2111	Na H antiporter
SMD_RS20320	COG1006	Multisubunit Na H antiporter MnhC subunit
SMD_RS20325	COG0651	ATP synthesis coupled electron transport
SMD_RS20330	COG1863	multisubunit Na H antiporter MnhE subunit
SMD_RS20335	COG2212	antiporter activity
SMD_RS20340	COG1320	monovalent cation:proton antiporter activity
SMD_RS20345	COG0530	calcium, potassium:sodium antiporter activity
SMD_RS20360	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SMD_RS20385	COG3104	oligopeptide transport
SMD_RS20390	COG3483	tryptophan 2,3-dioxygenase activity
SMD_RS20420	COG2378	regulation of single-species biofilm formation
SMD_RS20435	COG2354	Protein conserved in bacteria
SMD_RS20450	COG3264	Mechanosensitive ion channel
SMD_RS20450	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMD_RS20465	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMD_RS20500	COG1166	arginine decarboxylase activity
SMD_RS20505	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMD_RS20535	COG2960	long-chain fatty acid transporting porin activity
SMD_RS20575	COG0606	chelatase, subunit chli
SMD_RS20595	COG0561	phosphatase activity
SMD_RS20600	COG3932	Exopolysaccharide synthesis, ExoD
SMD_RS20630	COG1999	signal sequence binding
SMD_RS20635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SMD_RS20640	COG1845	cytochrome c oxidase, subunit III
SMD_RS20650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMD_RS20655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD_RS20670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMD_RS20730	COG2031	fatty acid transporter
SMD_RS20775	COG0673	inositol 2-dehydrogenase activity
SMD_RS20785	COG1501	Belongs to the glycosyl hydrolase 31 family
SMD_RS20790	COG2222	sugar isomerase
SMD_RS20795	COG1940	carbohydrate kinase activity
SMD_RS20805	COG1349	DNA-binding transcription factor activity
SMD_RS20810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMD_RS20815	COG2814	Major facilitator Superfamily
SMD_RS20850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMD_RS20855	COG0156	8-amino-7-oxononanoate synthase activity
SMD_RS20860	COG2267	carboxylic ester hydrolase activity
SMD_RS20880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMD_RS20900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMD_RS20905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMD_RS20910	COG2205	protein histidine kinase activity
SMD_RS20915	COG0745	RESPONSE REGULATOR receiver
SMD_RS20920	COG3541	Predicted nucleotidyltransferase
SMD_RS20925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMD_RS20950	COG0714	Associated with various cellular activities
SMD_RS20965	COG0754	glutathionylspermidine amidase activity
SMD_RS20975	COG0129	dihydroxy-acid dehydratase activity
SMD_RS20980	COG1199	ATP-dependent helicase activity
SMD_RS20990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMD_RS21010	COG3781	membrane
SMD_RS21040	COG0625	glutathione transferase activity
SMD_RS21060	COG2207	Transcriptional regulator
SMD_RS21075	COG4555	ABC transporter
SMD_RS21100	COG0543	2 iron, 2 sulfur cluster binding
SMD_RS21100	COG0633	Ferredoxin
SMD_RS21105	COG1131	(ABC) transporter
SMD_RS21110	COG0842	Transport permease protein
SMD_RS21120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMD_RS21130	COG0084	hydrolase, TatD family'
SMD_RS21135	COG1643	Atp-dependent helicase
SMD_RS21145	COG1187	pseudouridine synthase activity
SMD_RS21155	COG0667	Aldo Keto reductase
SMD_RS21170	COG1690	Belongs to the RtcB family
SMD_RS21185	COG0840	transmembrane signaling receptor activity
SMD_RS21190	COG0656	L-ascorbic acid biosynthetic process
SMD_RS21195	COG2267	carboxylic ester hydrolase activity
SMD_RS21200	COG0393	Putative heavy-metal-binding
SMD_RS21205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMD_RS21205	COG1042	CoA-binding domain protein
SMD_RS21205	COG0045	succinate-CoA ligase (ADP-forming) activity
SMD_RS21210	COG2239	Acts as a magnesium transporter
SMD_RS21220	COG3177	Filamentation induced by cAMP protein fic
SMD_RS21220	COG0666	response to abiotic stimulus
SMD_RS21225	COG3100	YcgL domain-containing protein
SMD_RS21235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMD_RS21240	COG1028	Short-chain dehydrogenase reductase Sdr
SMD_RS21260	COG0644	oxidoreductase
SMD_RS21280	COG2986	histidine ammonia-lyase
SMD_RS21290	COG0463	Glycosyl transferase, family 2
SMD_RS21305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD_RS21310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMD_RS21325	COG1294	oxidase, subunit
SMD_RS21330	COG1271	oxidase subunit
SMD_RS21340	COG1595	DNA-templated transcription, initiation
SMD_RS21380	COG0408	coproporphyrinogen oxidase activity
SMD_RS21390	COG2323	membrane
SMD_RS21405	COG0589	response to stress
SMD_RS21425	COG0210	DNA helicase
SMD_RS21435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMD_RS21445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMD_RS21450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMD_RS21455	COG1819	glycosyl
SMD_RS21470	COG0251	oxidation-reduction process
SMD_RS21505	COG0463	Glycosyl transferase, family 2
SMD_RS21520	COG1475	DNA binding
SMD_RS21525	COG1192	Involved in chromosome partitioning
SMD_RS21530	COG0357	Ribosomal RNA small subunit methyltransferase G
SMD_RS21535	COG2091	lysine biosynthetic process via aminoadipic acid
SMD_RS21580	COG1971	Probably functions as a manganese efflux pump
SMD_RS21585	COG2205	protein histidine kinase activity
SMD_RS21585	COG0784	Response regulator, receiver
SMD_RS21595	COG0443	Heat shock 70 kDa protein
SMD_RS21615	COG0729	surface antigen
SMD_RS21625	COG0752	glycyl-tRNA synthetase alpha subunit
SMD_RS21630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMD_RS21635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMD_RS21635	COG0519	Catalyzes the synthesis of GMP from XMP
SMD_RS21645	COG0805	protein transport
SMD_RS21655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMD_RS21665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMD_RS21675	COG0840	transmembrane signaling receptor activity
SMD_RS21730	COG3135	benzoate transporter
SMD_RS21750	COG2951	lytic endotransglycosylase activity
SMD_RS21755	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SMD_RS21760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMD_RS21765	COG3706	GGDEF domain
SMD_RS21795	COG0302	gtp cyclohydrolase
SMD_RS21835	COG1074	ATP-dependent DNA helicase activity
SMD_RS21840	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SMD_RS21845	COG1127	ABC transporter
SMD_RS21850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMD_RS21855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMD_RS21870	COG2853	Lipoprotein
SMD_RS21875	COG0386	Belongs to the glutathione peroxidase family
SMD_RS21885	COG1322	Protein conserved in bacteria
SMD_RS21895	COG0604	alcohol dehydrogenase
SMD_RS21900	COG0583	DNA-binding transcription factor activity
SMD_RS21920	COG0667	Aldo Keto reductase
SMD_RS21925	COG0531	amino acid
SMD_RS21935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMD_RS21940	COG0861	Integral membrane protein TerC family
SMD_RS21950	COG0584	glycerophosphoryl diester phosphodiesterase
SMD_RS21960	COG0726	polysaccharide deacetylase
SMD_RS21965	COG0706	membrane insertase activity
SMD_RS21970	COG0594	ribonuclease P activity
SMD_RS21975	COG0230	Belongs to the bacterial ribosomal protein bL34 family