locus-tag	class	description
I6I01_RS00005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I01_RS00025	COG3228	Belongs to the MtfA family
I6I01_RS00035	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I01_RS00035	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I01_RS00040	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6I01_RS00055	COG3657	addiction module killer protein
I6I01_RS00095	COG3237	CsbD-like
I6I01_RS00105	COG0180	Tryptophanyl-tRNA synthetase
I6I01_RS00130	COG0477	Major facilitator Superfamily
I6I01_RS00140	COG4152	abc transporter atp-binding protein
I6I01_RS00155	COG0697	spore germination
I6I01_RS00170	COG0577	efflux transmembrane transporter activity
I6I01_RS00170	COG1136	(ABC) transporter
I6I01_RS00180	COG1136	(ABC) transporter
I6I01_RS00200	COG4585	Histidine kinase
I6I01_RS00205	COG2197	response regulator
I6I01_RS00220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I01_RS00235	COG0628	permease
I6I01_RS00255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I01_RS00270	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6I01_RS00285	COG2197	response regulator
I6I01_RS00300	COG2814	Major facilitator Superfamily
I6I01_RS00305	COG0583	DNA-binding transcription factor activity
I6I01_RS00310	COG4807	Protein conserved in bacteria
I6I01_RS00320	COG4221	oxidoreductase activity
I6I01_RS00330	COG0018	arginyl-trna synthetase
I6I01_RS00335	COG2003	Belongs to the UPF0758 family
I6I01_RS00345	COG2197	response regulator
I6I01_RS00350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I01_RS00370	COG2205	protein histidine kinase activity
I6I01_RS00380	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I01_RS00385	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I01_RS00400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I01_RS00405	COG0708	Exodeoxyribonuclease III
I6I01_RS00410	COG2223	nitrite transmembrane transporter activity
I6I01_RS00425	COG0739	heme binding
I6I01_RS00430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I01_RS00490	COG2234	aminopeptidase activity
I6I01_RS00500	COG4942	peptidase
I6I01_RS00505	COG0793	Belongs to the peptidase S41A family
I6I01_RS00515	COG2067	long-chain fatty acid transport protein
I6I01_RS00540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I01_RS00585	COG0109	protoheme IX farnesyltransferase activity
I6I01_RS00605	COG0358	DNA primase activity
I6I01_RS00610	COG1295	ribonuclease BN
I6I01_RS00625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I01_RS00635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I01_RS00640	COG0668	transmembrane transport
I6I01_RS00655	COG2133	pyrroloquinoline quinone binding
I6I01_RS00660	COG4682	membrane
I6I01_RS00670	COG0531	amino acid
I6I01_RS00680	COG1737	Transcriptional regulator
I6I01_RS00685	COG4948	Mandelate Racemase Muconate Lactonizing
I6I01_RS00705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I01_RS00735	COG5383	Protein conserved in bacteria
I6I01_RS00745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I01_RS00750	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I01_RS00825	COG0778	Nitroreductase
I6I01_RS00830	COG2353	YceI-like domain
I6I01_RS00845	COG2375	cellular response to nickel ion
I6I01_RS00945	COG2267	carboxylic ester hydrolase activity
I6I01_RS01010	COG0488	(ABC) transporter
I6I01_RS01015	COG0583	DNA-binding transcription factor activity
I6I01_RS01025	COG2814	Major facilitator Superfamily
I6I01_RS01030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6I01_RS01035	COG1113	amino acid transport
I6I01_RS01040	COG0741	lytic transglycosylase activity
I6I01_RS01065	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6I01_RS01075	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6I01_RS01080	COG4941	Belongs to the sigma-70 factor family
I6I01_RS01110	COG3275	phosphorelay sensor kinase activity
I6I01_RS01115	COG3279	Response regulator of the LytR AlgR family
I6I01_RS01135	COG1309	transcriptional regulator
I6I01_RS01150	COG3590	peptidase
I6I01_RS01160	COG0583	DNA-binding transcription factor activity
I6I01_RS01170	COG3384	dioxygenase
I6I01_RS01175	COG0025	NhaP-type Na H and K H
I6I01_RS01200	COG1360	Flagellar Motor Protein
I6I01_RS01230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I01_RS01245	COG5002	protein histidine kinase activity
I6I01_RS01260	COG2813	Specifically methylates the guanine in position
I6I01_RS01265	COG1187	pseudouridine synthase activity
I6I01_RS01270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I01_RS01280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I01_RS01285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I01_RS01300	COG0583	DNA-binding transcription factor activity
I6I01_RS01305	COG2226	methyltransferase
I6I01_RS01330	COG1956	GAF domain-containing protein
I6I01_RS01335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I01_RS01340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I01_RS01345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I01_RS01350	COG0785	Cytochrome C biogenesis protein
I6I01_RS01350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I01_RS01355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I01_RS01360	COG0745	RESPONSE REGULATOR receiver
I6I01_RS01365	COG2205	protein histidine kinase activity
I6I01_RS01370	COG2205	protein histidine kinase activity
I6I01_RS01375	COG0745	RESPONSE REGULATOR receiver
I6I01_RS01380	COG0367	asparagine synthase
I6I01_RS01390	COG0720	synthase
I6I01_RS01405	COG0513	Belongs to the DEAD box helicase family
I6I01_RS01415	COG0625	glutathione transferase activity
I6I01_RS01455	COG0626	cystathionine gamma-synthase activity
I6I01_RS01470	COG0110	maltose O-acetyltransferase activity
I6I01_RS01475	COG0438	transferase activity, transferring glycosyl groups
I6I01_RS01475	COG1216	Glycosyl transferase, family 2
I6I01_RS01480	COG3754	Rhamnan synthesis protein F
I6I01_RS01520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I01_RS01525	COG2226	methyltransferase
I6I01_RS01530	COG0300	oxidoreductase activity
I6I01_RS01540	COG0546	phosphoglycolate phosphatase activity
I6I01_RS01540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I01_RS01555	COG2076	Multidrug Resistance protein
I6I01_RS01630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I01_RS01635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I01_RS01645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I01_RS01670	COG1127	ABC transporter
I6I01_RS01675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I01_RS01690	COG0442	prolyl-tRNA aminoacylation
I6I01_RS01700	COG1183	phosphatidylcholine synthase activity
I6I01_RS01710	COG0456	acetyltransferase
I6I01_RS01720	COG0525	valine-tRNA ligase activity
I6I01_RS01730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I01_RS01740	COG0795	lipopolysaccharide-transporting ATPase activity
I6I01_RS01755	COG4974	Belongs to the 'phage' integrase family
I6I01_RS01760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I01_RS01775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I01_RS01775	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I01_RS01780	COG5295	Hep Hag repeat protein
I6I01_RS01785	COG1404	Belongs to the peptidase S8 family
I6I01_RS01790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I01_RS01795	COG1459	type II secretion system
I6I01_RS01800	COG2165	general secretion pathway protein
I6I01_RS01805	COG4970	Tfp pilus assembly protein FimT
I6I01_RS01810	COG2165	general secretion pathway protein
I6I01_RS01815	COG4795	General secretion pathway protein
I6I01_RS01820	COG3156	type II secretion system protein K
I6I01_RS01825	COG3166	PFAM Fimbrial assembly family protein
I6I01_RS01840	COG1450	Type ii and iii secretion system protein
I6I01_RS01855	COG0463	Glycosyl transferase, family 2
I6I01_RS01860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I01_RS01870	COG3539	Fimbrial protein
I6I01_RS01900	COG1215	transferase activity, transferring glycosyl groups
I6I01_RS01915	COG2252	PERMEase
I6I01_RS01920	COG0488	(ABC) transporter
I6I01_RS01930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I01_RS01950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I01_RS01955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I01_RS01955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I01_RS01985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I01_RS01990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I01_RS02005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I01_RS02005	COG2755	lipolytic protein G-D-S-L family
I6I01_RS02010	COG0277	FAD linked oxidase domain protein
I6I01_RS02015	COG1988	membrane-bound metal-dependent
I6I01_RS02050	COG2001	Belongs to the MraZ family
I6I01_RS02055	COG0275	rRNA processing
I6I01_RS02060	COG3116	cell division
I6I01_RS02070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I01_RS02075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I01_RS02095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I01_RS02100	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I01_RS02105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I01_RS02115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I01_RS02120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6I01_RS02130	COG0739	heme binding
I6I01_RS02135	COG0653	protein targeting
I6I01_RS02140	COG0494	nUDIX hydrolase
I6I01_RS02150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I01_RS02160	COG3275	phosphorelay sensor kinase activity
I6I01_RS02165	COG3279	Response regulator of the LytR AlgR family
I6I01_RS02185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I01_RS02190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I01_RS02200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I01_RS02205	COG1607	acyl-coa hydrolase
I6I01_RS02210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I01_RS02240	COG4106	trans-aconitate 2-methyltransferase activity
I6I01_RS02245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I01_RS02265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I01_RS02270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I01_RS02275	COG0667	Aldo Keto reductase
I6I01_RS02285	COG4771	TonB-dependent receptor
I6I01_RS02300	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I01_RS02305	COG4181	ATPase activity
I6I01_RS02320	COG0642	Histidine kinase
I6I01_RS02330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I01_RS02335	COG0861	Integral membrane protein TerC family
I6I01_RS02340	COG2814	Major facilitator Superfamily
I6I01_RS02345	COG1704	LemA family
I6I01_RS02360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I01_RS02365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I01_RS02375	COG3738	Protein conserved in bacteria
I6I01_RS02380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I01_RS02385	COG2967	ApaG domain
I6I01_RS02390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I01_RS02395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I01_RS02400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I01_RS02405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I01_RS02415	COG2096	Adenosyltransferase
I6I01_RS02425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I01_RS02430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I01_RS02440	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6I01_RS02460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I01_RS02470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I01_RS02480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I01_RS02485	COG0583	DNA-binding transcription factor activity
I6I01_RS02490	COG3634	alkyl hydroperoxide reductase activity
I6I01_RS02530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I01_RS02530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I01_RS02545	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6I01_RS02570	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6I01_RS02585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I01_RS02605	COG1404	Belongs to the peptidase S8 family
I6I01_RS02625	COG1295	ribonuclease BN
I6I01_RS02630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I01_RS02645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I01_RS02650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I01_RS02665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I01_RS02675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I01_RS02680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I01_RS02685	COG0193	aminoacyl-tRNA hydrolase activity
I6I01_RS02690	COG0012	GTP binding
I6I01_RS02700	COG2197	response regulator
I6I01_RS02705	COG2205	protein histidine kinase activity
I6I01_RS02705	COG0784	Response regulator, receiver
I6I01_RS02710	COG2203	Gaf domain
I6I01_RS02710	COG2200	EAL domain
I6I01_RS02710	COG2199	diguanylate cyclase activity
I6I01_RS02715	COG2205	protein histidine kinase activity
I6I01_RS02715	COG0784	Response regulator, receiver
I6I01_RS02720	COG4206	TonB-dependent receptor
I6I01_RS02725	COG4242	Belongs to the peptidase S51 family
I6I01_RS02750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I01_RS02765	COG0250	Participates in transcription elongation, termination and antitermination
I6I01_RS02770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I01_RS02775	COG0081	regulation of translation
I6I01_RS02780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I01_RS02785	COG0222	ribosome binding
I6I01_RS02790	COG0085	RNA polymerase activity
I6I01_RS02795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I01_RS02800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I01_RS02805	COG0049	tRNA binding
I6I01_RS02810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I01_RS02815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I01_RS02820	COG0051	transcription antitermination factor activity, RNA binding
I6I01_RS02825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I01_RS02830	COG0088	Forms part of the polypeptide exit tunnel
I6I01_RS02835	COG0089	rRNA binding
I6I01_RS02840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I01_RS02845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I01_RS02850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I01_RS02855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I01_RS02860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I01_RS02865	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I01_RS02870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I01_RS02875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I01_RS02880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I01_RS02885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I01_RS02890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I01_RS02895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I01_RS02900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I01_RS02905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I01_RS02910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I01_RS02915	COG1841	ribosomal large subunit assembly
I6I01_RS02920	COG0200	Binds to the 23S rRNA
I6I01_RS02925	COG0201	protein transport
I6I01_RS02930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I01_RS02935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I01_RS02940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I01_RS02945	COG0202	RNA polymerase activity
I6I01_RS02950	COG0203	ribosomal protein L17
I6I01_RS02965	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6I01_RS02975	COG0154	amidase activity
I6I01_RS02990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I01_RS02995	COG0039	L-malate dehydrogenase activity
I6I01_RS03000	COG0564	pseudouridine synthase activity
I6I01_RS03005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I01_RS03020	COG0625	glutathione transferase activity
I6I01_RS03030	COG1902	pentaerythritol trinitrate reductase activity
I6I01_RS03030	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I01_RS03035	COG2364	Membrane
I6I01_RS03040	COG0604	alcohol dehydrogenase
I6I01_RS03055	COG1187	pseudouridine synthase activity
I6I01_RS03075	COG1063	alcohol dehydrogenase
I6I01_RS03085	COG0406	alpha-ribazole phosphatase activity
I6I01_RS03090	COG0285	dihydrofolate synthase activity
I6I01_RS03110	COG2833	Protein of unknown function (DUF455)
I6I01_RS03120	COG3291	Pkd domain containing protein
I6I01_RS03125	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I01_RS03135	COG0438	transferase activity, transferring glycosyl groups
I6I01_RS03150	COG0248	Ppx GppA phosphatase
I6I01_RS03155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I01_RS03170	COG4783	chaperone-mediated protein folding
I6I01_RS03185	COG0473	3-isopropylmalate dehydrogenase activity
I6I01_RS03195	COG0583	DNA-binding transcription factor activity
I6I01_RS03245	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I01_RS03250	COG0740	serine-type endopeptidase activity
I6I01_RS03255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I01_RS03290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I01_RS03295	COG3942	CHAP domain
I6I01_RS03295	COG1388	LysM domain
I6I01_RS03300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I01_RS03310	COG0328	RNA-DNA hybrid ribonuclease activity
I6I01_RS03315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I01_RS03320	COG0631	protein serine/threonine phosphatase activity
I6I01_RS03475	COG4373	Mu-like prophage FluMu protein gp28
I6I01_RS03600	COG2974	May be involved in recombination
I6I01_RS03640	COG0859	PFAM glycosyl transferase family 9
I6I01_RS03645	COG3642	lipopolysaccharide core region biosynthetic process
I6I01_RS03650	COG1234	tRNA 3'-trailer cleavage
I6I01_RS03665	COG2076	Multidrug Resistance protein
I6I01_RS03690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I01_RS03695	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I01_RS03705	COG0537	adenosine 5'-monophosphoramidase activity
I6I01_RS03725	COG0714	Associated with various cellular activities
I6I01_RS03740	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I01_RS03745	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I01_RS03750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I01_RS03760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I01_RS03765	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS03775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I01_RS03780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I01_RS03785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I01_RS03790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I01_RS03950	COG4774	siderophore transport
I6I01_RS03960	COG2223	nitrite transmembrane transporter activity
I6I01_RS03975	COG2226	methyltransferase
I6I01_RS03985	COG0583	DNA-binding transcription factor activity
I6I01_RS03990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I01_RS03995	COG0697	spore germination
I6I01_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS04005	COG0583	DNA-binding transcription factor activity
I6I01_RS04015	COG0477	Major facilitator Superfamily
I6I01_RS04050	COG0583	DNA-binding transcription factor activity
I6I01_RS04075	COG0667	Aldo Keto reductase
I6I01_RS04095	COG2818	Glycosylase
I6I01_RS04100	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I01_RS04105	COG1678	Uncharacterized ACR, COG1678
I6I01_RS04110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I01_RS04115	COG0540	Belongs to the ATCase OTCase family
I6I01_RS04135	COG2239	Acts as a magnesium transporter
I6I01_RS04140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I01_RS04155	COG1660	Displays ATPase and GTPase activities
I6I01_RS04160	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6I01_RS04165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I01_RS04170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I01_RS04180	COG1137	ATPase activity
I6I01_RS04195	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I01_RS04210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I01_RS04230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I01_RS04250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I01_RS04260	COG0628	permease
I6I01_RS04270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I01_RS04280	COG2261	transglycosylase associated protein
I6I01_RS04290	COG1555	photosystem II stabilization
I6I01_RS04310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I01_RS04315	COG1477	protein flavinylation
I6I01_RS04335	COG4771	TonB-dependent receptor
I6I01_RS04345	COG3128	pkhd-type hydroxylase
I6I01_RS04355	COG4774	siderophore transport
I6I01_RS04365	COG2146	nitrite reductase [NAD(P)H] activity
I6I01_RS04380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I01_RS04385	COG0719	Fe-S assembly protein
I6I01_RS04390	COG0396	ATPase activity
I6I01_RS04400	COG0719	Fe-S assembly protein
I6I01_RS04405	COG1959	2 iron, 2 sulfur cluster binding
I6I01_RS04415	COG0693	protein deglycase activity
I6I01_RS04440	COG1764	response to oxidative stress
I6I01_RS04445	COG0384	phenazine biosynthesis protein PhzF
I6I01_RS04450	COG0384	phenazine biosynthesis protein PhzF
I6I01_RS04455	COG0527	aspartate kinase activity
I6I01_RS04465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I01_RS04480	COG0142	geranyltranstransferase activity
I6I01_RS04485	COG0366	Alpha amylase catalytic
I6I01_RS04495	COG1082	Xylose isomerase domain protein TIM barrel
I6I01_RS04505	COG2211	Major facilitator Superfamily
I6I01_RS04505	COG2190	(PTS) system
I6I01_RS04545	COG1131	(ABC) transporter
I6I01_RS04555	COG0629	single-stranded DNA binding
I6I01_RS04590	COG0673	inositol 2-dehydrogenase activity
I6I01_RS04595	COG2211	Major facilitator Superfamily
I6I01_RS04605	COG1609	Transcriptional regulator
I6I01_RS04645	COG0640	Transcriptional regulator
I6I01_RS04660	COG3655	Transcriptional regulator
I6I01_RS04665	COG1253	flavin adenine dinucleotide binding
I6I01_RS04670	COG1408	metallophosphoesterase
I6I01_RS04675	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I01_RS04695	COG2259	Doxx family
I6I01_RS04725	COG0477	Major facilitator Superfamily
I6I01_RS04740	COG1802	Transcriptional regulator
I6I01_RS04775	COG3052	prosthetic group binding
I6I01_RS04790	COG0579	oxidoreductase
I6I01_RS04815	COG3104	oligopeptide transport
I6I01_RS04835	COG1297	OPT oligopeptide transporter protein
I6I01_RS04840	COG0823	Involved in the tonB-independent uptake of proteins
I6I01_RS04840	COG1506	peptidase
I6I01_RS04855	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I01_RS04860	COG2894	cell division
I6I01_RS04875	COG4585	Histidine kinase
I6I01_RS04880	COG2197	response regulator
I6I01_RS04920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I01_RS04930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I01_RS04940	COG1595	DNA-templated transcription, initiation
I6I01_RS04950	COG1946	Acyl-CoA thioesterase
I6I01_RS04970	COG0824	Thioesterase
I6I01_RS04975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I01_RS04980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I01_RS04985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I01_RS04990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I01_RS04995	COG0268	Binds directly to 16S ribosomal RNA
I6I01_RS05000	COG0728	peptidoglycan biosynthetic process
I6I01_RS05005	COG0196	riboflavin kinase activity
I6I01_RS05010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I01_RS05020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I01_RS05045	COG4206	TonB-dependent receptor
I6I01_RS05065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I01_RS05115	COG4227	nucleotidyltransferase activity
I6I01_RS05150	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6I01_RS05210	COG4191	Histidine kinase
I6I01_RS05210	COG0784	Response regulator, receiver
I6I01_RS05225	COG3685	Protein conserved in bacteria
I6I01_RS05365	COG1192	Involved in chromosome partitioning
I6I01_RS05395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I01_RS05445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I01_RS05475	COG0582	viral genome integration into host DNA
I6I01_RS05550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I01_RS05555	COG1845	cytochrome c oxidase, subunit III
I6I01_RS05560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I01_RS05575	COG0326	Molecular chaperone. Has ATPase activity
I6I01_RS05595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I01_RS05610	COG0228	four-way junction DNA binding
I6I01_RS05615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I01_RS05620	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I01_RS05625	COG0335	large ribosomal subunit rRNA binding
I6I01_RS05645	COG0534	Mate efflux family protein
I6I01_RS05665	COG0753	catalase activity
I6I01_RS05795	COG1309	transcriptional regulator
I6I01_RS05815	COG4959	Type IV secretory pathway protease TraF
I6I01_RS05830	COG1192	Involved in chromosome partitioning
I6I01_RS05855	COG1396	sequence-specific DNA binding
I6I01_RS05860	COG4644	lycopene metabolic process
I6I01_RS06030	COG1192	Involved in chromosome partitioning
I6I01_RS06100	COG0666	response to abiotic stimulus
I6I01_RS06110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I01_RS06150	COG3210	domain, Protein
I6I01_RS06200	COG0840	transmembrane signaling receptor activity
I6I01_RS06220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS06240	COG0024	Methionine aminopeptidase
I6I01_RS06265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I01_RS06290	COG1647	Serine aminopeptidase, S33
I6I01_RS06315	COG2814	Major facilitator Superfamily
I6I01_RS06320	COG3706	GGDEF domain
I6I01_RS06345	COG0588	phosphoglycerate mutase activity
I6I01_RS06350	COG3590	peptidase
I6I01_RS06360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I01_RS06370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I01_RS06375	COG0745	RESPONSE REGULATOR receiver
I6I01_RS06380	COG2205	protein histidine kinase activity
I6I01_RS06385	COG4452	Inner membrane protein CreD
I6I01_RS06400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I01_RS06405	COG0735	belongs to the Fur family
I6I01_RS06445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I01_RS06505	COG1187	pseudouridine synthase activity
I6I01_RS06515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I01_RS06540	COG1132	(ABC) transporter
I6I01_RS06600	COG1695	Transcriptional regulator
I6I01_RS06620	COG1981	membrane
I6I01_RS06625	COG0825	malonyl-CoA metabolic process
I6I01_RS06650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I01_RS06660	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I01_RS06665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I01_RS06670	COG0750	zinc metalloprotease
I6I01_RS06675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I01_RS06680	COG0575	Belongs to the CDS family
I6I01_RS06685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I01_RS06690	COG0233	cytoplasmic translational termination
I6I01_RS06695	COG0528	UMP kinase activity
I6I01_RS06705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I01_RS06710	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I01_RS06750	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I01_RS06760	COG1393	Belongs to the ArsC family
I6I01_RS06765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I01_RS06770	COG0367	asparagine synthase
I6I01_RS06775	COG0475	glutathione-regulated potassium exporter activity
I6I01_RS06810	COG1566	PFAM secretion protein HlyD family protein
I6I01_RS06815	COG2814	Major facilitator Superfamily
I6I01_RS06830	COG0583	DNA-binding transcription factor activity
I6I01_RS06850	COG0557	exoribonuclease II activity
I6I01_RS06860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I01_RS06870	COG1538	Outer membrane efflux protein
I6I01_RS06875	COG1136	(ABC) transporter
I6I01_RS06875	COG0577	efflux transmembrane transporter activity
I6I01_RS06880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS06900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I01_RS06905	COG2259	Doxx family
I6I01_RS06915	COG3220	belongs to the UPF0276 family
I6I01_RS06925	COG0704	Plays a role in the regulation of phosphate uptake
I6I01_RS06935	COG0581	inorganic phosphate transmembrane transporter activity
I6I01_RS06940	COG0573	inorganic phosphate transmembrane transporter activity
I6I01_RS06945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I01_RS06950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I01_RS06960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I01_RS06970	COG1024	Enoyl-CoA hydratase
I6I01_RS06980	COG0494	nUDIX hydrolase
I6I01_RS07000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I01_RS07000	COG0116	Belongs to the methyltransferase superfamily
I6I01_RS07020	COG2733	membrane
I6I01_RS07030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I01_RS07035	COG1012	belongs to the aldehyde dehydrogenase family
I6I01_RS07045	COG0477	Major facilitator Superfamily
I6I01_RS07050	COG2703	oxygen carrier activity
I6I01_RS07070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I01_RS07075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I01_RS07080	COG0174	glutamine synthetase
I6I01_RS07090	COG2072	flavoprotein involved in K transport
I6I01_RS07095	COG3842	ATPase activity
I6I01_RS07100	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I01_RS07105	COG1177	transmembrane transport
I6I01_RS07110	COG1012	belongs to the aldehyde dehydrogenase family
I6I01_RS07125	COG4535	Mg2 and Co2 transporter CorC
I6I01_RS07145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I01_RS07150	COG1702	phosphate starvation-inducible protein PhoH
I6I01_RS07155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS07160	COG1131	(ABC) transporter
I6I01_RS07165	COG0842	Transport permease protein
I6I01_RS07170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I01_RS07185	COG0741	lytic transglycosylase activity
I6I01_RS07190	COG0723	plastoquinol--plastocyanin reductase activity
I6I01_RS07195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I01_RS07200	COG2857	Cytochrome c1
I6I01_RS07205	COG0625	glutathione transferase activity
I6I01_RS07210	COG2969	positive regulation of protein catabolic process
I6I01_RS07245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I01_RS07255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I01_RS07270	COG1611	Belongs to the LOG family
I6I01_RS07310	COG4970	Tfp pilus assembly protein FimT
I6I01_RS07315	COG0556	nucleotide-excision repair
I6I01_RS07375	COG0811	peptide transport
I6I01_RS07390	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I01_RS07395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I01_RS07400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I01_RS07410	COG0322	excinuclease ABC activity
I6I01_RS07445	COG0577	efflux transmembrane transporter activity
I6I01_RS07445	COG1136	(ABC) transporter
I6I01_RS07505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I01_RS07530	COG0583	DNA-binding transcription factor activity
I6I01_RS07550	COG1917	Cupin 2, conserved barrel domain protein
I6I01_RS07550	COG4977	sequence-specific DNA binding
I6I01_RS07555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I01_RS07575	COG0348	domain, Protein
I6I01_RS07590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I01_RS07605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I01_RS07610	COG0069	glutamate synthase activity
I6I01_RS07635	COG1054	Belongs to the UPF0176 family
I6I01_RS07640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I01_RS07655	COG1253	flavin adenine dinucleotide binding
I6I01_RS07675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I01_RS07690	COG0504	CTP synthase activity
I6I01_RS07695	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I01_RS07710	COG0148	phosphopyruvate hydratase activity
I6I01_RS07715	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6I01_RS07720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I01_RS07725	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I01_RS07735	COG2840	Smr protein MutS2
I6I01_RS07740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I01_RS07745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I01_RS07770	COG1534	Rna-binding protein
I6I01_RS07775	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I01_RS07780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I01_RS07790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I01_RS07795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I01_RS07800	COG1923	regulation of RNA biosynthetic process
I6I01_RS07805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I01_RS07810	COG1546	Belongs to the CinA family
I6I01_RS07815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I01_RS07820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I01_RS07825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I01_RS07830	COG2137	regulation of response to DNA damage stimulus
I6I01_RS07835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I01_RS07840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I01_RS08055	COG3540	Alkaline phosphatase
I6I01_RS08070	COG3258	Cytochrome c
I6I01_RS08085	COG2223	nitrite transmembrane transporter activity
I6I01_RS08100	COG1741	Belongs to the pirin family
I6I01_RS08105	COG0583	DNA-binding transcription factor activity
I6I01_RS08130	COG0352	thiamine-phosphate diphosphorylase activity
I6I01_RS08130	COG0351	phosphomethylpyrimidine kinase
I6I01_RS08145	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I01_RS08150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I01_RS08160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I01_RS08170	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I01_RS08175	COG0477	Major facilitator Superfamily
I6I01_RS08185	COG0617	tRNA 3'-terminal CCA addition
I6I01_RS08195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I01_RS08200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I01_RS08210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I01_RS08215	COG0166	Belongs to the GPI family
I6I01_RS08220	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6I01_RS08230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I01_RS08235	COG0671	phosphoesterase, PA-phosphatase related
I6I01_RS08245	COG0800	Aldolase
I6I01_RS08250	COG0129	dihydroxy-acid dehydratase activity
I6I01_RS08260	COG0837	glucose binding
I6I01_RS08265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I01_RS08270	COG3842	ATPase activity
I6I01_RS08285	COG2009	succinate dehydrogenase
I6I01_RS08290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I01_RS08295	COG1053	succinate dehydrogenase
I6I01_RS08315	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I01_RS08330	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I01_RS08340	COG0552	protein localization to endoplasmic reticulum
I6I01_RS08355	COG0742	ribosomal rna small subunit methyltransferase
I6I01_RS08360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I01_RS08370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I01_RS08375	COG0405	Gamma-glutamyltransferase
I6I01_RS08380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I01_RS08400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I01_RS08420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I01_RS08430	COG0415	Belongs to the DNA photolyase family
I6I01_RS08435	COG2885	chlorophyll binding
I6I01_RS08440	COG0583	DNA-binding transcription factor activity
I6I01_RS08670	COG1802	Transcriptional regulator
I6I01_RS08670	COG4626	Terminase
I6I01_RS08675	COG4695	Portal protein
I6I01_RS08680	COG0740	serine-type endopeptidase activity
I6I01_RS08795	COG0582	viral genome integration into host DNA
I6I01_RS08865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I01_RS08875	COG2914	Belongs to the UPF0125 (RnfH) family
I6I01_RS08880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I01_RS08885	COG0735	belongs to the Fur family
I6I01_RS08895	COG0583	DNA-binding transcription factor activity
I6I01_RS08900	COG0497	DNA recombination
I6I01_RS08905	COG1420	regulation of RNA biosynthetic process
I6I01_RS08910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I01_RS08915	COG0443	Heat shock 70 kDa protein
I6I01_RS08920	COG0484	heat shock protein binding
I6I01_RS08925	COG2207	Transcriptional regulator
I6I01_RS08930	COG2223	nitrite transmembrane transporter activity
I6I01_RS08935	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6I01_RS08940	COG0287	Prephenate dehydrogenase
I6I01_RS08940	COG1605	Chorismate mutase
I6I01_RS08950	COG1132	(ABC) transporter
I6I01_RS08980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I01_RS08985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I01_RS08990	COG0343	queuine tRNA-ribosyltransferase activity
I6I01_RS08995	COG1862	Preprotein translocase
I6I01_RS09005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I01_RS09010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I01_RS09020	COG2081	HI0933 family
I6I01_RS09025	COG4681	YaeQ
I6I01_RS09045	COG0625	glutathione transferase activity
I6I01_RS09050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I01_RS09055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I01_RS09060	COG0513	Belongs to the DEAD box helicase family
I6I01_RS09070	COG0583	DNA-binding transcription factor activity
I6I01_RS09075	COG0488	(ABC) transporter
I6I01_RS09100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I01_RS09120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I01_RS09125	COG2957	Belongs to the agmatine deiminase family
I6I01_RS09135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I01_RS09140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I01_RS09150	COG0776	regulation of translation
I6I01_RS09160	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6I01_RS09165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I01_RS09175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I01_RS09180	COG0183	Belongs to the thiolase family
I6I01_RS09185	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I01_RS09185	COG1024	Enoyl-CoA hydratase
I6I01_RS09195	COG0105	UTP biosynthetic process
I6I01_RS09200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I01_RS09205	COG0859	PFAM glycosyl transferase family 9
I6I01_RS09205	COG0457	Tetratricopeptide repeat
I6I01_RS09210	COG1426	Protein conserved in bacteria
I6I01_RS09210	COG1426	Protein conserved in bacteria
I6I01_RS09220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I01_RS09225	COG1160	GTP binding
I6I01_RS09245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I01_RS09250	COG0475	glutathione-regulated potassium exporter activity
I6I01_RS09250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I01_RS09265	COG0519	Catalyzes the synthesis of GMP from XMP
I6I01_RS09265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I01_RS09305	COG0583	DNA-binding transcription factor activity
I6I01_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS09360	COG0640	Transcriptional regulator
I6I01_RS09375	COG4716	Myosin-crossreactive antigen
I6I01_RS09410	COG0431	NADPH-dependent FMN reductase
I6I01_RS09420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I01_RS09425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I01_RS09430	COG1473	amidohydrolase
I6I01_RS09440	COG1126	abc transporter atp-binding protein
I6I01_RS09445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I01_RS09465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6I01_RS09470	COG0583	DNA-binding transcription factor activity
I6I01_RS09475	COG0477	Major facilitator Superfamily
I6I01_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS09490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I01_RS09510	COG1309	transcriptional regulator
I6I01_RS09525	COG0697	spore germination
I6I01_RS09530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I01_RS09535	COG0167	dihydroorotate dehydrogenase activity
I6I01_RS09550	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS09555	COG1012	belongs to the aldehyde dehydrogenase family
I6I01_RS09600	COG4191	Histidine kinase
I6I01_RS09600	COG0784	Response regulator, receiver
I6I01_RS09605	COG4999	Histidine kinase
I6I01_RS09605	COG3437	response regulator, receiver
I6I01_RS09605	COG2205	protein histidine kinase activity
I6I01_RS09605	COG3850	Histidine kinase
I6I01_RS09610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I01_RS09630	COG0640	Transcriptional regulator
I6I01_RS09670	COG0527	aspartate kinase activity
I6I01_RS09670	COG0460	homoserine dehydrogenase
I6I01_RS09685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I01_RS09690	COG0124	histidyl-tRNA synthetase
I6I01_RS09700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I01_RS09705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I01_RS09710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I01_RS09715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I01_RS09715	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I01_RS09720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I01_RS09725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I01_RS09730	COG0107	imidazoleglycerol-phosphate synthase activity
I6I01_RS09735	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I01_RS09735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I01_RS09755	COG1446	asparaginase
I6I01_RS09760	COG3142	Participates in the control of copper homeostasis
I6I01_RS09770	COG2217	Heavy metal translocating P-type atpase
I6I01_RS09775	COG0789	Transcriptional regulator
I6I01_RS09790	COG3537	Alpha-1,2-mannosidase
I6I01_RS09795	COG1609	Transcriptional regulator
I6I01_RS09805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I01_RS09820	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6I01_RS09825	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6I01_RS09830	COG0235	Class ii aldolase
I6I01_RS09845	COG0531	amino acid
I6I01_RS09850	COG0531	amino acid
I6I01_RS09860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I01_RS09865	COG0277	FAD linked oxidase domain protein
I6I01_RS09880	COG2205	protein histidine kinase activity
I6I01_RS09885	COG0745	RESPONSE REGULATOR receiver
I6I01_RS09890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS09910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I01_RS09955	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I01_RS09970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I01_RS09975	COG0505	Belongs to the CarA family
I6I01_RS09980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I01_RS09985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I01_RS10000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I01_RS10005	COG4676	Protein conserved in bacteria
I6I01_RS10015	COG3279	Response regulator of the LytR AlgR family
I6I01_RS10030	COG1012	belongs to the aldehyde dehydrogenase family
I6I01_RS10050	COG0784	Response regulator, receiver
I6I01_RS10050	COG2198	Histidine kinase
I6I01_RS10050	COG2205	protein histidine kinase activity
I6I01_RS10055	COG1024	Enoyl-CoA hydratase
I6I01_RS10060	COG0318	PFAM AMP-dependent synthetase and ligase
I6I01_RS10065	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I01_RS10070	COG1012	belongs to the aldehyde dehydrogenase family
I6I01_RS10075	COG1309	transcriptional regulator
I6I01_RS10080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I01_RS10125	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6I01_RS10135	COG0840	transmembrane signaling receptor activity
I6I01_RS10140	COG0840	transmembrane signaling receptor activity
I6I01_RS10150	COG0835	chemotaxis
I6I01_RS10155	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6I01_RS10160	COG0840	transmembrane signaling receptor activity
I6I01_RS10170	COG0745	RESPONSE REGULATOR receiver
I6I01_RS10180	COG0835	chemotaxis
I6I01_RS10190	COG1360	Flagellar Motor Protein
I6I01_RS10195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I01_RS10200	COG0643	Histidine kinase
I6I01_RS10200	COG2198	Histidine kinase
I6I01_RS10200	COG0784	Response regulator, receiver
I6I01_RS10205	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I01_RS10230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I01_RS10235	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I01_RS10255	COG1987	bacterial-type flagellum assembly
I6I01_RS10265	COG3190	flagellar
I6I01_RS10315	COG1677	Flagellar hook-basal body complex protein FliE
I6I01_RS10335	COG2197	response regulator
I6I01_RS10355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6I01_RS10395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6I01_RS10405	COG4787	bacterial-type flagellum-dependent cell motility
I6I01_RS10420	COG1558	bacterial-type flagellum-dependent cell motility
I6I01_RS10425	COG1815	bacterial-type flagellum-dependent cell motility
I6I01_RS10430	COG0835	chemotaxis
I6I01_RS10430	COG0784	Response regulator, receiver
I6I01_RS10450	COG5002	protein histidine kinase activity
I6I01_RS10485	COG2915	High frequency lysogenization protein hflD homolog
I6I01_RS10490	COG0482	sulfurtransferase activity
I6I01_RS10505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I01_RS10515	COG0542	response to heat
I6I01_RS10545	COG0492	ferredoxin-NADP+ reductase activity
I6I01_RS10550	COG1674	ftsk spoiiie
I6I01_RS10570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I01_RS10585	COG2819	hydrolase of the alpha beta superfamily
I6I01_RS10595	COG4558	Periplasmic binding protein
I6I01_RS10600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I01_RS10605	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I01_RS10615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I01_RS10630	COG0784	Response regulator, receiver
I6I01_RS10630	COG5002	protein histidine kinase activity
I6I01_RS10645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I01_RS10660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I01_RS10670	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6I01_RS10685	COG1595	DNA-templated transcription, initiation
I6I01_RS10705	COG0784	Response regulator, receiver
I6I01_RS10710	COG4251	negative regulation of phosphorylation
I6I01_RS10720	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I6I01_RS10730	COG0456	acetyltransferase
I6I01_RS10730	COG0454	-acetyltransferase
I6I01_RS10735	COG2205	protein histidine kinase activity
I6I01_RS10800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS10805	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I01_RS10820	COG0010	Belongs to the arginase family
I6I01_RS10875	COG2132	Multicopper oxidase
I6I01_RS10900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I01_RS10955	COG4644	lycopene metabolic process
I6I01_RS11055	COG1309	transcriptional regulator
I6I01_RS11070	COG4221	oxidoreductase activity
I6I01_RS11115	COG3685	Protein conserved in bacteria
I6I01_RS11140	COG3546	catalase activity
I6I01_RS11170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I01_RS11190	COG1063	alcohol dehydrogenase
I6I01_RS11220	COG1609	Transcriptional regulator
I6I01_RS11225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I01_RS11225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I01_RS11230	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I01_RS11235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I01_RS11235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I01_RS11250	COG1733	regulation of RNA biosynthetic process
I6I01_RS11255	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6I01_RS11270	COG4771	TonB-dependent receptor
I6I01_RS11275	COG0738	Major facilitator superfamily
I6I01_RS11280	COG1609	Transcriptional regulator
I6I01_RS11285	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I01_RS11300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I01_RS11315	COG2828	Protein conserved in bacteria
I6I01_RS11320	COG0583	DNA-binding transcription factor activity
I6I01_RS11345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I01_RS11350	COG0583	DNA-binding transcription factor activity
I6I01_RS11380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I01_RS11405	COG0642	Histidine kinase
I6I01_RS11415	COG0318	PFAM AMP-dependent synthetase and ligase
I6I01_RS11430	COG2186	Transcriptional regulator
I6I01_RS11450	COG2271	Major facilitator Superfamily
I6I01_RS11455	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS11465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I01_RS11495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I01_RS11515	COG0583	DNA-binding transcription factor activity
I6I01_RS11540	COG2204	response regulator
I6I01_RS11615	COG0708	Exodeoxyribonuclease III
I6I01_RS11620	COG0366	Alpha amylase catalytic
I6I01_RS11635	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS11645	COG0577	efflux transmembrane transporter activity
I6I01_RS11645	COG1136	(ABC) transporter
I6I01_RS11650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS11660	COG0745	RESPONSE REGULATOR receiver
I6I01_RS11665	COG2205	protein histidine kinase activity
I6I01_RS11675	COG3214	Protein conserved in bacteria
I6I01_RS11685	COG4774	siderophore transport
I6I01_RS11710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I01_RS11715	COG1285	pathogenesis
I6I01_RS11720	COG4191	Histidine kinase
I6I01_RS11725	COG4566	intracellular signal transduction
I6I01_RS11795	COG0243	molybdopterin cofactor binding
I6I01_RS11820	COG0477	Major facilitator Superfamily
I6I01_RS11845	COG1136	(ABC) transporter
I6I01_RS11860	COG0583	DNA-binding transcription factor activity
I6I01_RS11865	COG0656	L-ascorbic acid biosynthetic process
I6I01_RS11885	COG2372	response to copper ion
I6I01_RS11900	COG5002	protein histidine kinase activity
I6I01_RS11905	COG0583	DNA-binding transcription factor activity
I6I01_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS11940	COG3537	Alpha-1,2-mannosidase
I6I01_RS11955	COG0477	Major facilitator Superfamily
I6I01_RS11975	COG2202	Pas domain
I6I01_RS11975	COG3920	Histidine kinase
I6I01_RS12020	COG1335	isochorismatase
I6I01_RS12025	COG1335	isochorismatase
I6I01_RS12055	COG0811	peptide transport
I6I01_RS12195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I01_RS12200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I01_RS12210	COG0840	transmembrane signaling receptor activity
I6I01_RS12215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I01_RS12220	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I01_RS12225	COG4149	molybdate abc transporter
I6I01_RS12235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I01_RS12250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I01_RS12255	COG2181	nitrate reductase activity
I6I01_RS12260	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6I01_RS12265	COG1140	nitrate reductase beta subunit
I6I01_RS12270	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I01_RS12275	COG2223	nitrite transmembrane transporter activity
I6I01_RS12285	COG0746	molybdenum cofactor guanylyltransferase activity
I6I01_RS12290	COG0314	molybdopterin synthase activity
I6I01_RS12300	COG0303	'Molybdopterin
I6I01_RS12305	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I01_RS12305	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I01_RS12310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I01_RS12355	COG2207	Transcriptional regulator
I6I01_RS12405	COG2205	protein histidine kinase activity
I6I01_RS12415	COG2194	sulfuric ester hydrolase activity
I6I01_RS12435	COG2885	chlorophyll binding
I6I01_RS12450	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS12455	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6I01_RS12455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I01_RS12465	COG3433	isochorismatase activity
I6I01_RS12465	COG1535	isochorismatase
I6I01_RS12470	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6I01_RS12475	COG1169	isochorismate synthase
I6I01_RS12485	COG2409	Drug exporters of the RND superfamily
I6I01_RS12490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I01_RS12555	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I01_RS12575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I01_RS12580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I01_RS12585	COG0604	alcohol dehydrogenase
I6I01_RS12585	COG3321	synthase
I6I01_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS12590	COG4206	TonB-dependent receptor
I6I01_RS12595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I01_RS12605	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I01_RS12610	COG2205	protein histidine kinase activity
I6I01_RS12615	COG0745	RESPONSE REGULATOR receiver
I6I01_RS12650	COG0583	DNA-binding transcription factor activity
I6I01_RS12660	COG4772	TonB-dependent receptor
I6I01_RS12680	COG2226	methyltransferase
I6I01_RS12725	COG4964	Belongs to the GSP D family
I6I01_RS12780	COG2814	Major facilitator Superfamily
I6I01_RS12790	COG1228	amidohydrolase
I6I01_RS12800	COG1335	isochorismatase
I6I01_RS12815	COG3850	Histidine kinase
I6I01_RS12820	COG2197	response regulator
I6I01_RS12825	COG2814	Major facilitator Superfamily
I6I01_RS12875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6I01_RS12885	COG0583	DNA-binding transcription factor activity
I6I01_RS12900	COG3161	chorismate lyase activity
I6I01_RS12910	COG4771	TonB-dependent receptor
I6I01_RS12940	COG0277	FAD linked oxidase domain protein
I6I01_RS12945	COG1304	FMN binding
I6I01_RS12950	COG2186	Transcriptional regulator
I6I01_RS12960	COG1285	pathogenesis
I6I01_RS12985	COG2814	Major facilitator Superfamily
I6I01_RS13040	COG0587	DNA-directed DNA polymerase activity
I6I01_RS13055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I01_RS13060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I01_RS13060	COG0519	Catalyzes the synthesis of GMP from XMP
I6I01_RS13075	COG1595	DNA-templated transcription, initiation
I6I01_RS13085	COG1629	transport
I6I01_RS13085	COG4206	TonB-dependent receptor
I6I01_RS13115	COG0531	amino acid
I6I01_RS13130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I01_RS13140	COG0789	Transcriptional regulator
I6I01_RS13225	COG5001	Diguanylate cyclase
I6I01_RS13225	COG5002	protein histidine kinase activity
I6I01_RS13225	COG3447	MASE1 domain protein
I6I01_RS13230	COG2183	response to ionizing radiation
I6I01_RS13245	COG1983	PspC domain protein
I6I01_RS13255	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6I01_RS13270	COG1073	alpha beta
I6I01_RS13270	COG2226	methyltransferase
I6I01_RS13275	COG0534	Mate efflux family protein
I6I01_RS13295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I01_RS13305	COG0668	transmembrane transport
I6I01_RS13310	COG1902	pentaerythritol trinitrate reductase activity
I6I01_RS13320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I01_RS13330	COG1733	regulation of RNA biosynthetic process
I6I01_RS13335	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I01_RS13340	COG0456	acetyltransferase
I6I01_RS13415	COG3702	type iv secretory pathway
I6I01_RS13435	COG2948	multi-organism process
I6I01_RS13445	COG3736	Type IV secretory pathway, component VirB8
I6I01_RS13455	COG3505	Type IV secretory pathway VirD4
I6I01_RS13470	COG2814	Major facilitator Superfamily
I6I01_RS13475	COG0789	Transcriptional regulator
I6I01_RS13510	COG4191	Histidine kinase
I6I01_RS13510	COG0784	Response regulator, receiver
I6I01_RS13525	COG4774	siderophore transport
I6I01_RS13545	COG1733	regulation of RNA biosynthetic process
I6I01_RS13550	COG0604	alcohol dehydrogenase
I6I01_RS13560	COG0210	DNA helicase
I6I01_RS13635	COG0583	DNA-binding transcription factor activity
I6I01_RS13640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I01_RS13650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I01_RS13665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I01_RS13670	COG1605	Chorismate mutase
I6I01_RS13670	COG0077	Prephenate dehydratase
I6I01_RS13675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I01_RS13720	COG1228	amidohydrolase
I6I01_RS13735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I01_RS13785	COG2957	Belongs to the agmatine deiminase family
I6I01_RS13790	COG0583	DNA-binding transcription factor activity
I6I01_RS13840	COG4993	Dehydrogenase
I6I01_RS13850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6I01_RS13860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6I01_RS13870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I01_RS13875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I01_RS13890	COG0359	binds to the 23S rRNA
I6I01_RS13895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I01_RS13900	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I01_RS13910	COG0316	Belongs to the HesB IscA family
I6I01_RS13915	COG0017	Asparaginyl-tRNA synthetase
I6I01_RS13935	COG0288	reversible hydration of carbon dioxide
I6I01_RS13945	COG3844	kynureninase activity
I6I01_RS13950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I01_RS13955	COG2925	Exonuclease
I6I01_RS13980	COG2902	Dehydrogenase
I6I01_RS13990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS13995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I01_RS14010	COG1960	acyl-CoA dehydrogenase activity
I6I01_RS14015	COG2226	methyltransferase
I6I01_RS14025	COG1410	methionine synthase
I6I01_RS14025	COG0646	methionine synthase
I6I01_RS14040	COG2900	Belongs to the SlyX family
I6I01_RS14055	COG0386	Belongs to the glutathione peroxidase family
I6I01_RS14065	COG1725	Transcriptional regulator
I6I01_RS14070	COG1131	(ABC) transporter
I6I01_RS14095	COG0114	fumarate hydratase activity
I6I01_RS14110	COG2850	peptidyl-arginine hydroxylation
I6I01_RS14120	COG0567	Dehydrogenase, E1 component
I6I01_RS14145	COG3540	Alkaline phosphatase
I6I01_RS14155	COG0305	Participates in initiation and elongation during chromosome replication
I6I01_RS14175	COG0625	glutathione transferase activity
I6I01_RS14195	COG0084	hydrolase, TatD family'
I6I01_RS14200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I01_RS14235	COG0625	glutathione transferase activity
I6I01_RS14250	COG1595	DNA-templated transcription, initiation
I6I01_RS14260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I01_RS14275	COG0386	Belongs to the glutathione peroxidase family
I6I01_RS14280	COG0339	signal peptide processing
I6I01_RS14290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I01_RS14310	COG0705	Rhomboid family
I6I01_RS14315	COG3104	oligopeptide transport
I6I01_RS14325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I01_RS14330	COG4290	ribonuclease
I6I01_RS14345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I01_RS14345	COG0316	Belongs to the HesB IscA family
I6I01_RS14350	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6I01_RS14360	COG0428	transporter
I6I01_RS14370	COG1530	ribonuclease E activity
I6I01_RS14385	COG0395	ABC-type sugar transport system, permease component
I6I01_RS14415	COG0271	Belongs to the BolA IbaG family
I6I01_RS14420	COG2350	Protein conserved in bacteria
I6I01_RS14425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I01_RS14430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I01_RS14435	COG1187	pseudouridine synthase activity
I6I01_RS14445	COG2814	Major facilitator Superfamily
I6I01_RS14465	COG0436	Aminotransferase
I6I01_RS14470	COG4133	protoheme IX ABC transporter activity
I6I01_RS14490	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I01_RS14505	COG3088	subunit of a heme lyase
I6I01_RS14505	COG4235	cytochrome complex assembly
I6I01_RS14515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I01_RS14525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I01_RS14530	COG4988	ABC transporter
I6I01_RS14540	COG1294	oxidase, subunit
I6I01_RS14570	COG0726	polysaccharide deacetylase
I6I01_RS14570	COG1649	PFAM Uncharacterised BCR, COG1649
I6I01_RS14575	COG1215	transferase activity, transferring glycosyl groups
I6I01_RS14585	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I01_RS14600	COG0165	Argininosuccinate lyase
I6I01_RS14605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I01_RS14615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I01_RS14620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I01_RS14625	COG0137	argininosuccinate synthase activity
I6I01_RS14630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I01_RS14645	COG2166	iron-sulfur cluster assembly
I6I01_RS14665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I01_RS14685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I01_RS14690	COG0402	S-adenosylhomocysteine deaminase activity
I6I01_RS14695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I01_RS14700	COG1509	lysine 2,3-aminomutase activity
I6I01_RS14705	COG3300	MHYT domain
I6I01_RS14705	COG5001	Diguanylate cyclase
I6I01_RS14725	COG0501	Belongs to the peptidase M48B family
I6I01_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS14755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I01_RS14760	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I01_RS14765	COG0802	atpase or kinase
I6I01_RS14770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I01_RS14770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I01_RS14775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I01_RS14780	COG1570	exodeoxyribonuclease VII activity
I6I01_RS14790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I01_RS14810	COG4771	TonB-dependent receptor
I6I01_RS14830	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS14840	COG2130	NADP-dependent
I6I01_RS14865	COG1396	sequence-specific DNA binding
I6I01_RS14870	COG2856	Zn peptidase
I6I01_RS14890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I01_RS14970	COG1475	DNA binding
I6I01_RS15030	COG0616	signal peptide processing
I6I01_RS15255	COG1960	acyl-CoA dehydrogenase activity
I6I01_RS15265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I01_RS15300	COG2076	Multidrug Resistance protein
I6I01_RS15305	COG5487	UPF0391 membrane protein
I6I01_RS15310	COG1280	lysine exporter protein (LysE YggA)
I6I01_RS15315	COG1794	racemase activity, acting on amino acids and derivatives
I6I01_RS15350	COG0776	regulation of translation
I6I01_RS15355	COG0072	phenylalanine-tRNA ligase activity
I6I01_RS15355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I01_RS15360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I01_RS15365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I01_RS15370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I01_RS15375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I01_RS15380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I01_RS15415	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I01_RS15420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I01_RS15430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I01_RS15435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I01_RS15440	COG0195	Participates in both transcription termination and antitermination
I6I01_RS15445	COG0779	Required for maturation of 30S ribosomal subunits
I6I01_RS15460	COG1007	ATP synthesis coupled electron transport
I6I01_RS15475	COG0713	ATP synthesis coupled electron transport
I6I01_RS15485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I01_RS15490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I01_RS15505	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6I01_RS15510	COG0649	NAD binding
I6I01_RS15515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I01_RS15520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I01_RS15525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I01_RS15540	COG0149	triose-phosphate isomerase activity
I6I01_RS15550	COG3083	sulfuric ester hydrolase activity
I6I01_RS15555	COG0438	transferase activity, transferring glycosyl groups
I6I01_RS15560	COG0726	polysaccharide deacetylase
I6I01_RS15565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I01_RS15570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I01_RS15575	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I01_RS15580	COG0159	tryptophan synthase activity
I6I01_RS15590	COG0133	tryptophan synthase activity
I6I01_RS15610	COG0135	phosphoribosylanthranilate isomerase activity
I6I01_RS15615	COG0101	tRNA pseudouridine synthase activity
I6I01_RS15630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I01_RS15640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I01_RS15645	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I01_RS15650	COG1999	signal sequence binding
I6I01_RS15655	COG0688	phosphatidylethanolamine metabolic process
I6I01_RS15670	COG0433	COG0433 Predicted ATPase
I6I01_RS15675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I01_RS15685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I01_RS15690	COG0412	Dienelactone hydrolase
I6I01_RS15705	COG0717	Belongs to the dCTP deaminase family
I6I01_RS15710	COG0489	protein tyrosine kinase activity
I6I01_RS15715	COG4771	TonB-dependent receptor
I6I01_RS15720	COG4771	TonB-dependent receptor
I6I01_RS15730	COG3590	peptidase
I6I01_RS15765	COG0697	spore germination
I6I01_RS15775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I01_RS15780	COG2311	Membrane
I6I01_RS15785	COG1047	Peptidyl-prolyl cis-trans
I6I01_RS15790	COG0791	NLP P60 protein
I6I01_RS15795	COG0791	NLP P60 protein
I6I01_RS15800	COG1301	dicarboxylic acid transport
I6I01_RS15820	COG1722	exodeoxyribonuclease VII activity
I6I01_RS15825	COG0142	geranyltranstransferase activity
I6I01_RS15835	COG0312	modulator of DNA gyrase
I6I01_RS15840	COG3028	Belongs to the UPF0307 family
I6I01_RS15845	COG0312	modulator of DNA gyrase
I6I01_RS15865	COG2968	Membrane
I6I01_RS15875	COG4771	TonB-dependent receptor
I6I01_RS15890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I01_RS15900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I01_RS15915	COG0495	leucyl-tRNA aminoacylation
I6I01_RS15925	COG3118	belongs to the thioredoxin family
I6I01_RS15935	COG5001	Diguanylate cyclase
I6I01_RS15935	COG3706	GGDEF domain
I6I01_RS15935	COG2203	Gaf domain
I6I01_RS15935	COG4251	negative regulation of phosphorylation
I6I01_RS15955	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I01_RS15965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I01_RS15970	COG0346	lactoylglutathione lyase activity
I6I01_RS15980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I01_RS15980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I01_RS15990	COG2878	Part of a membrane complex involved in electron transport
I6I01_RS15995	COG3415	Transposase
I6I01_RS15995	COG2801	Transposase and inactivated derivatives
I6I01_RS16000	COG0251	oxidation-reduction process
I6I01_RS16005	COG0392	lysyltransferase activity
I6I01_RS16005	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I01_RS16035	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I01_RS16040	COG0443	Heat shock 70 kDa protein
I6I01_RS16080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I01_RS16085	COG3122	Protein conserved in bacteria
I6I01_RS16090	COG1451	nucleotide metabolic process
I6I01_RS16100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I01_RS16120	COG0183	Belongs to the thiolase family
I6I01_RS16135	COG1960	acyl-CoA dehydrogenase activity
I6I01_RS16145	COG1793	dna ligase
I6I01_RS16150	COG1201	RNA secondary structure unwinding
I6I01_RS16165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I01_RS16170	COG1278	Cold shock
I6I01_RS16175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6I01_RS16180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I01_RS16185	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I01_RS16190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I01_RS16195	COG2954	triphosphatase activity
I6I01_RS16200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I01_RS16205	COG0745	RESPONSE REGULATOR receiver
I6I01_RS16210	COG1381	Involved in DNA repair and RecF pathway recombination
I6I01_RS16215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I01_RS16230	COG0681	Belongs to the peptidase S26 family
I6I01_RS16235	COG0481	GTPase activity
I6I01_RS16240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I01_RS16260	COG1741	Belongs to the pirin family
I6I01_RS16265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I01_RS16275	COG1741	Belongs to the pirin family
I6I01_RS16280	COG1966	Carbon starvation protein
I6I01_RS16285	COG2879	small protein
I6I01_RS16300	COG2205	protein histidine kinase activity
I6I01_RS16340	COG2814	Major facilitator Superfamily
I6I01_RS16345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I01_RS16345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I01_RS16355	COG1113	amino acid transport
I6I01_RS16360	COG2207	Transcriptional regulator
I6I01_RS16360	COG1917	Cupin 2, conserved barrel domain protein
I6I01_RS16365	COG0753	catalase activity
I6I01_RS16395	COG1376	ErfK ybiS ycfS ynhG family protein
I6I01_RS16400	COG0739	heme binding
I6I01_RS16410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I01_RS16420	COG0330	HflC and HflK could
I6I01_RS16425	COG0330	HflC and HflK could
I6I01_RS16430	COG0604	alcohol dehydrogenase
I6I01_RS16445	COG0678	peroxiredoxin activity
I6I01_RS16455	COG4953	penicillin-binding protein 1C
I6I01_RS16460	COG2373	Large extracellular alpha-helical protein
I6I01_RS16465	COG2079	MmgE PrpD family protein
I6I01_RS16470	COG2828	Protein conserved in bacteria
I6I01_RS16480	COG3609	addiction module antidote protein, CC2985 family
I6I01_RS16500	COG3829	transcription factor binding
I6I01_RS16525	COG0259	pyridoxamine-phosphate oxidase activity
I6I01_RS16540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I01_RS16560	COG0477	Major facilitator Superfamily
I6I01_RS16580	COG3038	cytochrome b561
I6I01_RS16595	COG1760	l-serine dehydratase
I6I01_RS16600	COG3415	Transposase
I6I01_RS16600	COG2801	Transposase and inactivated derivatives
I6I01_RS16605	COG2267	carboxylic ester hydrolase activity
I6I01_RS16610	COG0527	aspartate kinase activity
I6I01_RS16610	COG0460	homoserine dehydrogenase
I6I01_RS16615	COG0626	cystathionine gamma-synthase activity
I6I01_RS16620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I01_RS16625	COG0739	heme binding
I6I01_RS16630	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I01_RS16635	COG1272	protein, Hemolysin III
I6I01_RS16650	COG0463	Glycosyl transferase, family 2
I6I01_RS16655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I01_RS16660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I01_RS16670	COG4206	TonB-dependent receptor
I6I01_RS16675	COG1309	transcriptional regulator
I6I01_RS16685	COG1960	acyl-CoA dehydrogenase activity
I6I01_RS16715	COG0583	DNA-binding transcription factor activity
I6I01_RS16725	COG0509	glycine decarboxylation via glycine cleavage system
I6I01_RS16730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I01_RS16740	COG0330	HflC and HflK could
I6I01_RS16750	COG1742	UPF0060 membrane protein
I6I01_RS16755	COG3956	TIGRFAM MazG family protein
I6I01_RS16760	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I01_RS16765	COG0494	nUDIX hydrolase
I6I01_RS16775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I01_RS16790	COG0784	Response regulator, receiver
I6I01_RS16790	COG0643	Histidine kinase
I6I01_RS16790	COG2198	Histidine kinase
I6I01_RS16795	COG0840	transmembrane signaling receptor activity
I6I01_RS16800	COG0835	chemotaxis
I6I01_RS16815	COG0189	ligase activity
I6I01_RS16830	COG1199	ATP-dependent helicase activity
I6I01_RS16840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I01_RS16845	COG1215	transferase activity, transferring glycosyl groups
I6I01_RS16860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I01_RS16870	COG1643	Atp-dependent helicase
I6I01_RS16875	COG0783	Belongs to the Dps family
I6I01_RS16880	COG0514	ATP-dependent DNA helicase (RecQ)
I6I01_RS16945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I01_RS16950	COG0602	queuosine metabolic process
I6I01_RS16960	COG2885	chlorophyll binding
I6I01_RS16965	COG0823	Involved in the tonB-independent uptake of proteins
I6I01_RS16980	COG0811	peptide transport
I6I01_RS16985	COG0824	Thioesterase
I6I01_RS16990	COG2255	four-way junction helicase activity
I6I01_RS17000	COG0632	four-way junction helicase activity
I6I01_RS17005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I01_RS17010	COG0217	transcriptional regulatory protein
I6I01_RS17030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I01_RS17060	COG0488	(ABC) transporter
I6I01_RS17085	COG4651	solute:proton antiporter activity
I6I01_RS17085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I01_RS17095	COG0745	RESPONSE REGULATOR receiver
I6I01_RS17100	COG2205	protein histidine kinase activity
I6I01_RS17110	COG0542	response to heat
I6I01_RS17130	COG0028	Belongs to the TPP enzyme family
I6I01_RS17155	COG3387	PFAM Glycoside hydrolase 15-related
I6I01_RS17160	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I01_RS17165	COG3011	Protein conserved in bacteria
I6I01_RS17180	COG0564	pseudouridine synthase activity
I6I01_RS17185	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I01_RS17195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I01_RS17195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I01_RS17205	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I01_RS17240	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6I01_RS17255	COG2205	protein histidine kinase activity
I6I01_RS17260	COG0745	RESPONSE REGULATOR receiver
I6I01_RS17275	COG0189	ligase activity
I6I01_RS17300	COG3240	lipase activity
I6I01_RS17300	COG4625	pathogenesis
I6I01_RS17310	COG2022	thiamine diphosphate biosynthetic process
I6I01_RS17315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I01_RS17320	COG0471	metal ion transport
I6I01_RS17320	COG3273	potassium ion transport
I6I01_RS17340	COG1970	mechanosensitive ion channel activity
I6I01_RS17350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I01_RS17355	COG1115	amino acid carrier protein
I6I01_RS17365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I01_RS17370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS17395	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6I01_RS17405	COG3588	fructose-bisphosphate aldolase
I6I01_RS17410	COG0469	pyruvate kinase activity
I6I01_RS17420	COG0126	phosphoglycerate kinase activity
I6I01_RS17435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I01_RS17480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I01_RS17485	COG1301	dicarboxylic acid transport
I6I01_RS17515	COG0714	Associated with various cellular activities
I6I01_RS17545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I01_RS17610	COG0254	rRNA binding
I6I01_RS17620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I01_RS17630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I01_RS17635	COG1758	RNA polymerase activity
I6I01_RS17650	COG0437	4 iron, 4 sulfur cluster binding
I6I01_RS17655	COG2864	formate dehydrogenase
I6I01_RS17665	COG1921	L-seryl-tRNASec selenium transferase activity
I6I01_RS17670	COG3276	selenocysteine insertion sequence binding
I6I01_RS17680	COG0709	Synthesizes selenophosphate from selenide and ATP
I6I01_RS17695	COG1561	YicC-like family, N-terminal region
I6I01_RS17700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I01_RS17705	COG0346	lactoylglutathione lyase activity
I6I01_RS17715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I01_RS17730	COG0006	proline dipeptidase activity
I6I01_RS17735	COG0006	proline dipeptidase activity
I6I01_RS17740	COG3079	Belongs to the UPF0149 family
I6I01_RS17760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I01_RS17770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I01_RS17780	COG2912	Transglutaminase-like superfamily
I6I01_RS17785	COG1773	rubredoxin
I6I01_RS17790	COG0352	thiamine-phosphate diphosphorylase activity
I6I01_RS17795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I01_RS17800	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6I01_RS17810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I01_RS17815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I01_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS17845	COG0671	phosphoesterase, PA-phosphatase related
I6I01_RS17855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I01_RS17860	COG0563	adenylate kinase activity
I6I01_RS17880	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6I01_RS17890	COG0848	biopolymer transport protein
I6I01_RS17900	COG2832	Protein of unknown function (DUF454)
I6I01_RS17935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I01_RS17960	COG0745	RESPONSE REGULATOR receiver
I6I01_RS17970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I01_RS17975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I01_RS17985	COG0405	Gamma-glutamyltransferase
I6I01_RS17990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I01_RS18010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I01_RS18015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I01_RS18030	COG0473	3-isopropylmalate dehydrogenase activity
I6I01_RS18045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I01_RS18050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS18065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I01_RS18070	COG1538	Outer membrane efflux protein
I6I01_RS18075	COG0531	amino acid
I6I01_RS18080	COG1519	Transferase
I6I01_RS18085	COG1560	Kdo2-lipid A biosynthetic process
I6I01_RS18115	COG3415	Transposase
I6I01_RS18115	COG2801	Transposase and inactivated derivatives
I6I01_RS18125	COG1301	dicarboxylic acid transport
I6I01_RS18135	COG4191	Histidine kinase
I6I01_RS18150	COG0642	Histidine kinase
I6I01_RS18165	COG2851	Citrate transporter
I6I01_RS18170	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS18190	COG1162	GTPase activity
I6I01_RS18195	COG0436	Aminotransferase
I6I01_RS18215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I01_RS18230	COG1228	amidohydrolase
I6I01_RS18235	COG0804	urea catabolic process
I6I01_RS18245	COG1307	EDD domain protein, DegV family
I6I01_RS18285	COG3706	GGDEF domain
I6I01_RS18285	COG4251	negative regulation of phosphorylation
I6I01_RS18285	COG5001	Diguanylate cyclase
I6I01_RS18285	COG2203	Gaf domain
I6I01_RS18290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I01_RS18300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I01_RS18315	COG1902	pentaerythritol trinitrate reductase activity
I6I01_RS18340	COG0583	DNA-binding transcription factor activity
I6I01_RS18345	COG1064	alcohol dehydrogenase
I6I01_RS18365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6I01_RS18370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I01_RS18380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I01_RS18385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I01_RS18400	COG1522	sequence-specific DNA binding
I6I01_RS18410	COG4773	Receptor
I6I01_RS18420	COG4206	TonB-dependent receptor
I6I01_RS18445	COG0617	tRNA 3'-terminal CCA addition
I6I01_RS18490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I01_RS18495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I01_RS18500	COG1609	Transcriptional regulator
I6I01_RS18510	COG0837	glucose binding
I6I01_RS18520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6I01_RS18540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I01_RS18555	COG4191	Histidine kinase
I6I01_RS18560	COG0784	Response regulator, receiver
I6I01_RS18565	COG4251	negative regulation of phosphorylation
I6I01_RS18570	COG2823	Periplasmic or secreted lipoprotein
I6I01_RS18575	COG0673	inositol 2-dehydrogenase activity
I6I01_RS18580	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6I01_RS18600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I01_RS18610	COG2921	Belongs to the UPF0250 family
I6I01_RS18620	COG1686	Belongs to the peptidase S11 family
I6I01_RS18625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I01_RS18630	COG2951	lytic endotransglycosylase activity
I6I01_RS18635	COG0772	Belongs to the SEDS family
I6I01_RS18640	COG0772	Belongs to the SEDS family
I6I01_RS18655	COG1792	Involved in formation and maintenance of cell shape
I6I01_RS18660	COG1077	Cell shape determining protein MreB Mrl
I6I01_RS18665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I01_RS18680	COG0308	aminopeptidase N
I6I01_RS18685	COG2226	methyltransferase
I6I01_RS18730	COG0673	inositol 2-dehydrogenase activity
I6I01_RS18740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I01_RS18760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I01_RS18770	COG2832	Protein of unknown function (DUF454)
I6I01_RS18780	COG0436	Aminotransferase
I6I01_RS18785	COG1505	serine-type exopeptidase activity
I6I01_RS18810	COG0697	spore germination
I6I01_RS18815	COG1666	GTP binding
I6I01_RS18830	COG0339	signal peptide processing
I6I01_RS18840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I01_RS18860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I01_RS18870	COG1136	(ABC) transporter
I6I01_RS18880	COG0577	efflux transmembrane transporter activity
I6I01_RS18890	COG2204	response regulator
I6I01_RS18895	COG4191	Histidine kinase
I6I01_RS18905	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I01_RS18915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I01_RS18920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I01_RS18925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I01_RS18930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I01_RS18935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I01_RS18940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I01_RS18950	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I01_RS18965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I01_RS18970	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I01_RS18990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I01_RS19015	COG0181	hydroxymethylbilane synthase activity
I6I01_RS19025	COG2972	Histidine kinase
I6I01_RS19025	COG0745	RESPONSE REGULATOR receiver
I6I01_RS19030	COG0400	carboxylic ester hydrolase activity
I6I01_RS19040	COG4771	TonB-dependent receptor
I6I01_RS19075	COG0477	Major facilitator Superfamily
I6I01_RS19120	COG4206	TonB-dependent receptor
I6I01_RS19140	COG0625	glutathione transferase activity
I6I01_RS19155	COG2259	Doxx family
I6I01_RS19175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I01_RS19180	COG1490	D-aminoacyl-tRNA deacylase activity
I6I01_RS19190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I01_RS19230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I01_RS19230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I01_RS19235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I01_RS19240	COG0242	peptide deformylase activity
I6I01_RS19250	COG0758	DNA mediated transformation
I6I01_RS19255	COG2922	Belongs to the Smg family
I6I01_RS19265	COG1714	RDD family
I6I01_RS19270	COG1754	DNA topoisomerase type I activity
I6I01_RS19270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I01_RS19275	COG0009	L-threonylcarbamoyladenylate synthase
I6I01_RS19290	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS19300	COG0616	signal peptide processing
I6I01_RS19305	COG0534	Mate efflux family protein
I6I01_RS19320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I01_RS19325	COG0625	glutathione transferase activity
I6I01_RS19335	COG1252	NADH dehydrogenase
I6I01_RS19355	COG2860	membrane
I6I01_RS19360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I01_RS19380	COG1846	Transcriptional regulator
I6I01_RS19415	COG0459	protein refolding
I6I01_RS19420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I01_RS19425	COG2356	endonuclease I
I6I01_RS19430	COG1324	tolerance protein
I6I01_RS19440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I01_RS19470	COG4585	Histidine kinase
I6I01_RS19490	COG0583	DNA-binding transcription factor activity
I6I01_RS19500	COG1785	Belongs to the alkaline phosphatase family
I6I01_RS19505	COG1686	Belongs to the peptidase S11 family
I6I01_RS19515	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I01_RS19525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6I01_RS19535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I01_RS19540	COG0511	ligase activity, forming carbon-carbon bonds
I6I01_RS19545	COG0439	Biotin carboxylase
I6I01_RS19560	COG2264	protein methyltransferase activity
I6I01_RS19570	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I01_RS19575	COG4589	Belongs to the CDS family
I6I01_RS19580	COG0204	Acyl-transferase
I6I01_RS19590	COG0671	phosphoesterase, PA-phosphatase related
I6I01_RS19590	COG2453	phosphatase
I6I01_RS19595	COG2267	carboxylic ester hydrolase activity
I6I01_RS19600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I01_RS19605	COG0138	bifunctional purine biosynthesis protein purh
I6I01_RS19610	COG0151	Belongs to the GarS family
I6I01_RS19625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I01_RS19630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I01_RS19635	COG2201	protein-glutamate methylesterase activity
I6I01_RS19640	COG2177	Part of the ABC transporter FtsEX involved in
I6I01_RS19645	COG2884	Cell division ATP-binding protein ftsE
I6I01_RS19655	COG3118	belongs to the thioredoxin family
I6I01_RS19660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I01_RS19665	COG3706	GGDEF domain
I6I01_RS19675	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I01_RS19710	COG1652	LysM domain
I6I01_RS19715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I01_RS19715	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I01_RS19720	COG1473	amidohydrolase
I6I01_RS19725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS19730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I01_RS19735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I01_RS19740	COG1289	transmembrane transporter activity
I6I01_RS19745	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS19750	COG2814	Major facilitator Superfamily
I6I01_RS19780	COG0316	Belongs to the HesB IscA family
I6I01_RS19820	COG1051	belongs to the nudix hydrolase family
I6I01_RS19835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I01_RS19840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I01_RS19845	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6I01_RS19855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I01_RS19860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I01_RS19865	COG0730	response to heat
I6I01_RS19875	COG0134	indole-3-glycerol-phosphate synthase activity
I6I01_RS19880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I01_RS19900	COG1597	lipid kinase activity
I6I01_RS19915	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I01_RS19920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I01_RS19930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I01_RS19930	COG2111	Na H antiporter
I6I01_RS19935	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I01_RS19940	COG0651	ATP synthesis coupled electron transport
I6I01_RS19945	COG1863	multisubunit Na H antiporter MnhE subunit
I6I01_RS19950	COG2212	antiporter activity
I6I01_RS19955	COG1320	monovalent cation:proton antiporter activity
I6I01_RS19960	COG0530	calcium, potassium:sodium antiporter activity
I6I01_RS19975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6I01_RS19990	COG4804	nuclease activity
I6I01_RS20005	COG3104	oligopeptide transport
I6I01_RS20010	COG3483	tryptophan 2,3-dioxygenase activity
I6I01_RS20045	COG2378	regulation of single-species biofilm formation
I6I01_RS20060	COG2354	Protein conserved in bacteria
I6I01_RS20065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I01_RS20070	COG1368	sulfuric ester hydrolase activity
I6I01_RS20075	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I01_RS20075	COG3264	Mechanosensitive ion channel
I6I01_RS20090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I01_RS20130	COG1166	arginine decarboxylase activity
I6I01_RS20135	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I01_RS20150	COG3415	Transposase
I6I01_RS20150	COG2801	Transposase and inactivated derivatives
I6I01_RS20160	COG2960	long-chain fatty acid transporting porin activity
I6I01_RS20240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I01_RS20240	COG3453	Protein conserved in bacteria
I6I01_RS20255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I01_RS20275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I01_RS20290	COG0431	NADPH-dependent FMN reductase
I6I01_RS20305	COG0798	PFAM Bile acid sodium symporter
I6I01_RS20320	COG0659	secondary active sulfate transmembrane transporter activity
I6I01_RS20325	COG0604	alcohol dehydrogenase
I6I01_RS20330	COG0583	DNA-binding transcription factor activity
I6I01_RS20335	COG4221	oxidoreductase activity
I6I01_RS20390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I01_RS20390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I01_RS20405	COG1902	pentaerythritol trinitrate reductase activity
I6I01_RS20470	COG0402	S-adenosylhomocysteine deaminase activity
I6I01_RS20515	COG0561	phosphatase activity
I6I01_RS20520	COG3932	Exopolysaccharide synthesis, ExoD
I6I01_RS20550	COG1999	signal sequence binding
I6I01_RS20555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I01_RS20560	COG1845	cytochrome c oxidase, subunit III
I6I01_RS20570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I01_RS20575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I01_RS20590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I01_RS20595	COG1104	cysteine desulfurase activity
I6I01_RS20650	COG2031	fatty acid transporter
I6I01_RS20655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I01_RS20695	COG0673	inositol 2-dehydrogenase activity
I6I01_RS20705	COG1501	Belongs to the glycosyl hydrolase 31 family
I6I01_RS20710	COG2222	sugar isomerase
I6I01_RS20715	COG1940	carbohydrate kinase activity
I6I01_RS20725	COG1349	DNA-binding transcription factor activity
I6I01_RS20730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I01_RS20735	COG2814	Major facilitator Superfamily
I6I01_RS20775	COG3210	domain, Protein
I6I01_RS20790	COG1040	competence protein
I6I01_RS20810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I01_RS20815	COG0156	8-amino-7-oxononanoate synthase activity
I6I01_RS20820	COG2267	carboxylic ester hydrolase activity
I6I01_RS20840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I01_RS20860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I01_RS20865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I01_RS20870	COG2205	protein histidine kinase activity
I6I01_RS20875	COG0745	RESPONSE REGULATOR receiver
I6I01_RS20880	COG3541	Predicted nucleotidyltransferase
I6I01_RS20885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I01_RS20910	COG0714	Associated with various cellular activities
I6I01_RS20925	COG0754	glutathionylspermidine amidase activity
I6I01_RS20935	COG0129	dihydroxy-acid dehydratase activity
I6I01_RS20940	COG1199	ATP-dependent helicase activity
I6I01_RS20950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I01_RS20970	COG3781	membrane
I6I01_RS21000	COG0625	glutathione transferase activity
I6I01_RS21020	COG2207	Transcriptional regulator
I6I01_RS21035	COG4555	ABC transporter
I6I01_RS21065	COG0543	2 iron, 2 sulfur cluster binding
I6I01_RS21065	COG0633	Ferredoxin
I6I01_RS21070	COG1131	(ABC) transporter
I6I01_RS21075	COG0842	Transport permease protein
I6I01_RS21085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I01_RS21095	COG0084	hydrolase, TatD family'
I6I01_RS21100	COG1643	Atp-dependent helicase
I6I01_RS21110	COG1187	pseudouridine synthase activity
I6I01_RS21125	COG0667	Aldo Keto reductase
I6I01_RS21145	COG1690	Belongs to the RtcB family
I6I01_RS21160	COG0840	transmembrane signaling receptor activity
I6I01_RS21165	COG0583	DNA-binding transcription factor activity
I6I01_RS21170	COG2814	Major facilitator Superfamily
I6I01_RS21180	COG2267	carboxylic ester hydrolase activity
I6I01_RS21205	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I01_RS21205	COG1042	CoA-binding domain protein
I6I01_RS21205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I01_RS21210	COG2239	Acts as a magnesium transporter
I6I01_RS21220	COG0666	response to abiotic stimulus
I6I01_RS21220	COG3177	Filamentation induced by cAMP protein fic
I6I01_RS21225	COG3100	YcgL domain-containing protein
I6I01_RS21240	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS21280	COG2986	histidine ammonia-lyase
I6I01_RS21290	COG0463	Glycosyl transferase, family 2
I6I01_RS21305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I01_RS21310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I01_RS21325	COG1294	oxidase, subunit
I6I01_RS21330	COG1271	oxidase subunit
I6I01_RS21345	COG1595	DNA-templated transcription, initiation
I6I01_RS21380	COG0408	coproporphyrinogen oxidase activity
I6I01_RS21390	COG2323	membrane
I6I01_RS21405	COG0589	response to stress
I6I01_RS21425	COG0210	DNA helicase
I6I01_RS21435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I01_RS21440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I01_RS21445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I01_RS21450	COG1819	glycosyl
I6I01_RS21465	COG0251	oxidation-reduction process
I6I01_RS21500	COG0463	Glycosyl transferase, family 2
I6I01_RS21515	COG1475	DNA binding
I6I01_RS21520	COG1192	Involved in chromosome partitioning
I6I01_RS21525	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I01_RS21530	COG2091	lysine biosynthetic process via aminoadipic acid
I6I01_RS21570	COG1971	Probably functions as a manganese efflux pump
I6I01_RS21575	COG2205	protein histidine kinase activity
I6I01_RS21575	COG0784	Response regulator, receiver
I6I01_RS21585	COG0443	Heat shock 70 kDa protein
I6I01_RS21595	COG2911	Protein conserved in bacteria
I6I01_RS21600	COG0729	surface antigen
I6I01_RS21610	COG0752	glycyl-tRNA synthetase alpha subunit
I6I01_RS21615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I01_RS21620	COG0519	Catalyzes the synthesis of GMP from XMP
I6I01_RS21620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I01_RS21630	COG0805	protein transport
I6I01_RS21640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I01_RS21650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I01_RS21660	COG0840	transmembrane signaling receptor activity
I6I01_RS21715	COG3135	benzoate transporter
I6I01_RS21730	COG2951	lytic endotransglycosylase activity
I6I01_RS21735	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6I01_RS21740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I01_RS21745	COG3706	GGDEF domain
I6I01_RS21775	COG0302	gtp cyclohydrolase
I6I01_RS21790	COG1566	PFAM secretion protein HlyD family protein
I6I01_RS21800	COG1289	transmembrane transporter activity
I6I01_RS21815	COG1074	ATP-dependent DNA helicase activity
I6I01_RS21820	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I01_RS21825	COG1127	ABC transporter
I6I01_RS21830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I01_RS21835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I01_RS21850	COG2853	Lipoprotein
I6I01_RS21855	COG0386	Belongs to the glutathione peroxidase family
I6I01_RS21865	COG1322	Protein conserved in bacteria
I6I01_RS21875	COG0604	alcohol dehydrogenase
I6I01_RS21880	COG0583	DNA-binding transcription factor activity
I6I01_RS21900	COG0531	amino acid
I6I01_RS21915	COG2378	regulation of single-species biofilm formation
I6I01_RS21920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I01_RS21925	COG0861	Integral membrane protein TerC family
I6I01_RS21935	COG0584	glycerophosphoryl diester phosphodiesterase
I6I01_RS21950	COG0706	membrane insertase activity
I6I01_RS21955	COG0594	ribonuclease P activity
I6I01_RS21960	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I01_RS21965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I01_RS21975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I01_RS21980	COG0187	DNA topoisomerase II activity
I6I01_RS21985	COG1266	CAAX protease self-immunity
I6I01_RS21990	COG0501	Belongs to the peptidase M48B family
I6I01_RS22025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I01_RS22060	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I01_RS22070	COG4772	TonB-dependent receptor
I6I01_RS22155	COG4695	Portal protein
I6I01_RS22165	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6I01_RS22175	COG0800	Aldolase
I6I01_RS22190	COG3186	Phenylalanine-4-hydroxylase
I6I01_RS22195	COG1522	sequence-specific DNA binding
I6I01_RS22200	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I01_RS22210	COG4771	TonB-dependent receptor
I6I01_RS22230	COG1119	ATPase activity
I6I01_RS22245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I01_RS22250	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6I01_RS22260	COG1435	thymidine kinase activity
I6I01_RS22265	COG0210	DNA helicase
I6I01_RS22280	COG3132	Protein of unknown function, DUF480
I6I01_RS22285	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6I01_RS22290	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I01_RS22300	COG2937	Belongs to the GPAT DAPAT family
I6I01_RS22310	COG0037	tRNA processing
I6I01_RS22315	COG2974	May be involved in recombination
I6I01_RS22325	COG1803	Methylglyoxal synthase
I6I01_RS22330	COG2205	protein histidine kinase activity
I6I01_RS22330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I01_RS22335	COG0493	'glutamate synthase
I6I01_RS22340	COG0070	glutamate synthase
I6I01_RS22340	COG0069	glutamate synthase activity
I6I01_RS22340	COG0067	glutamate synthase
I6I01_RS22360	COG1028	Short-chain dehydrogenase reductase Sdr
I6I01_RS22375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I01_RS22400	COG1205	dead DEAH box helicase
I6I01_RS22400	COG1111	helicase
I6I01_RS22435	COG0714	Associated with various cellular activities
I6I01_RS22455	COG0312	modulator of DNA gyrase
I6I01_RS22465	COG3550	peptidyl-serine autophosphorylation
I6I01_RS22485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I01_RS22505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I01_RS22530	COG1881	PFAM PEBP family protein
I6I01_RS22545	COG1968	undecaprenyl-diphosphatase activity
I6I01_RS22550	COG0174	glutamine synthetase
I6I01_RS22555	COG0347	Belongs to the P(II) protein family
I6I01_RS22560	COG0004	ammonium transporteR
I6I01_RS22565	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I01_RS22575	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6I01_RS22590	COG3852	Histidine kinase
I6I01_RS22595	COG2204	response regulator
I6I01_RS22600	COG2032	superoxide dismutase activity
I6I01_RS22605	COG2032	superoxide dismutase activity
I6I01_RS22615	COG0183	Belongs to the thiolase family
I6I01_RS22650	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I01_RS22655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I01_RS22675	COG0798	PFAM Bile acid sodium symporter
I6I01_RS22680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I01_RS22690	COG0431	NADPH-dependent FMN reductase
I6I01_RS22725	COG2837	iron assimilation
I6I01_RS22770	COG2197	response regulator
I6I01_RS22775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I01_RS22775	COG2205	protein histidine kinase activity
I6I01_RS22780	COG3474	cytochrome
I6I01_RS22790	COG1960	acyl-CoA dehydrogenase activity
I6I01_RS22795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I01_RS22805	COG0612	Peptidase, M16
I6I01_RS22815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I01_RS22820	COG0596	Alpha beta hydrolase
I6I01_RS22830	COG0318	PFAM AMP-dependent synthetase and ligase
I6I01_RS22835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I01_RS22845	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I01_RS22855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I01_RS22885	COG0339	signal peptide processing
I6I01_RS22900	COG0681	Belongs to the peptidase S26 family
I6I01_RS22905	COG2814	Major facilitator Superfamily
I6I01_RS22915	COG0583	DNA-binding transcription factor activity
I6I01_RS22920	COG0583	DNA-binding transcription factor activity
I6I01_RS22925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I01_RS22930	COG2224	Isocitrate lyase
I6I01_RS22935	COG3706	GGDEF domain
I6I01_RS22960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I01_RS22965	COG1960	acyl-CoA dehydrogenase activity
I6I01_RS22985	COG0697	spore germination
I6I01_RS22995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I01_RS23005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I01_RS23015	COG1280	lysine exporter protein (LysE YggA)
I6I01_RS23020	COG1607	acyl-coa hydrolase
I6I01_RS23030	COG1902	pentaerythritol trinitrate reductase activity
I6I01_RS23045	COG1335	isochorismatase
I6I01_RS23050	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I01_RS23060	COG1056	cytidyltransferase-related domain
I6I01_RS23060	COG1051	belongs to the nudix hydrolase family
I6I01_RS23065	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I01_RS23070	COG1396	sequence-specific DNA binding
I6I01_RS23070	COG3800	Transcriptional regulator
I6I01_RS23080	COG1960	acyl-CoA dehydrogenase activity
I6I01_RS23085	COG1024	Enoyl-CoA hydratase
I6I01_RS23090	COG1024	Enoyl-CoA hydratase
I6I01_RS23100	COG1764	response to oxidative stress
I6I01_RS23285	COG3179	chitinase
I6I01_RS23330	COG4695	Portal protein