locus-tag	class	description
K1516_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K1516_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K1516_RS00020	COG0187	DNA topoisomerase II activity
K1516_RS00025	COG1266	CAAX protease self-immunity
K1516_RS00030	COG0501	Belongs to the peptidase M48B family
K1516_RS00110	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K1516_RS00120	COG4772	TonB-dependent receptor
K1516_RS00155	COG0800	Aldolase
K1516_RS00170	COG3186	Phenylalanine-4-hydroxylase
K1516_RS00175	COG1522	sequence-specific DNA binding
K1516_RS00185	COG1752	Esterase of the alpha-beta hydrolase superfamily
K1516_RS00195	COG4771	TonB-dependent receptor
K1516_RS00215	COG1119	ATPase activity
K1516_RS00235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K1516_RS00240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K1516_RS00250	COG0210	DNA helicase
K1516_RS00265	COG3132	Protein of unknown function, DUF480
K1516_RS00270	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K1516_RS00275	COG0284	orotidine-5'-phosphate decarboxylase activity
K1516_RS00285	COG2937	Belongs to the GPAT DAPAT family
K1516_RS00295	COG0037	tRNA processing
K1516_RS00300	COG2974	May be involved in recombination
K1516_RS00310	COG1803	Methylglyoxal synthase
K1516_RS00315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1516_RS00315	COG2205	protein histidine kinase activity
K1516_RS00320	COG0493	'glutamate synthase
K1516_RS00325	COG0069	glutamate synthase activity
K1516_RS00325	COG0067	glutamate synthase
K1516_RS00325	COG0070	glutamate synthase
K1516_RS00345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K1516_RS00360	COG2814	Major facilitator Superfamily
K1516_RS00390	COG1111	helicase
K1516_RS00390	COG1205	dead DEAH box helicase
K1516_RS00425	COG0714	Associated with various cellular activities
K1516_RS00445	COG0312	modulator of DNA gyrase
K1516_RS00465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1516_RS00485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K1516_RS00515	COG0431	NADPH-dependent FMN reductase
K1516_RS00525	COG1968	undecaprenyl-diphosphatase activity
K1516_RS00530	COG0174	glutamine synthetase
K1516_RS00535	COG0347	Belongs to the P(II) protein family
K1516_RS00540	COG0004	ammonium transporteR
K1516_RS00570	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K1516_RS00585	COG3852	Histidine kinase
K1516_RS00590	COG2204	response regulator
K1516_RS00595	COG2032	superoxide dismutase activity
K1516_RS00600	COG2032	superoxide dismutase activity
K1516_RS00610	COG0183	Belongs to the thiolase family
K1516_RS00645	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K1516_RS00650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K1516_RS00710	COG2837	iron assimilation
K1516_RS00740	COG2197	response regulator
K1516_RS00745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1516_RS00745	COG2205	protein histidine kinase activity
K1516_RS00750	COG3474	cytochrome
K1516_RS00760	COG1960	acyl-CoA dehydrogenase activity
K1516_RS00765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K1516_RS00775	COG0612	Peptidase, M16
K1516_RS00785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K1516_RS00790	COG0596	Alpha beta hydrolase
K1516_RS00800	COG0318	PFAM AMP-dependent synthetase and ligase
K1516_RS00805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K1516_RS00815	COG1181	Belongs to the D-alanine--D-alanine ligase family
K1516_RS00825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K1516_RS00855	COG0339	signal peptide processing
K1516_RS00870	COG0681	Belongs to the peptidase S26 family
K1516_RS00875	COG2814	Major facilitator Superfamily
K1516_RS00880	COG0583	DNA-binding transcription factor activity
K1516_RS00885	COG0583	DNA-binding transcription factor activity
K1516_RS00890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K1516_RS00895	COG2224	Isocitrate lyase
K1516_RS00900	COG3706	GGDEF domain
K1516_RS00925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K1516_RS00930	COG1960	acyl-CoA dehydrogenase activity
K1516_RS00950	COG0697	spore germination
K1516_RS00960	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K1516_RS00975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1516_RS00985	COG1280	lysine exporter protein (LysE YggA)
K1516_RS00990	COG1607	acyl-coa hydrolase
K1516_RS01000	COG1902	pentaerythritol trinitrate reductase activity
K1516_RS01015	COG1335	isochorismatase
K1516_RS01020	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K1516_RS01030	COG1051	belongs to the nudix hydrolase family
K1516_RS01030	COG1056	cytidyltransferase-related domain
K1516_RS01035	COG1752	Esterase of the alpha-beta hydrolase superfamily
K1516_RS01045	COG3800	Transcriptional regulator
K1516_RS01045	COG1396	sequence-specific DNA binding
K1516_RS01055	COG1960	acyl-CoA dehydrogenase activity
K1516_RS01060	COG1024	Enoyl-CoA hydratase
K1516_RS01065	COG1024	Enoyl-CoA hydratase
K1516_RS01075	COG1764	response to oxidative stress
K1516_RS01085	COG0659	secondary active sulfate transmembrane transporter activity
K1516_RS01095	COG3657	addiction module killer protein
K1516_RS01100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K1516_RS01120	COG3228	Belongs to the MtfA family
K1516_RS01130	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K1516_RS01130	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K1516_RS01135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K1516_RS01185	COG3237	CsbD-like
K1516_RS01195	COG0180	Tryptophanyl-tRNA synthetase
K1516_RS01220	COG0477	Major facilitator Superfamily
K1516_RS01225	COG0697	spore germination
K1516_RS01235	COG4206	TonB-dependent receptor
K1516_RS01245	COG1136	(ABC) transporter
K1516_RS01245	COG0577	efflux transmembrane transporter activity
K1516_RS01255	COG1136	(ABC) transporter
K1516_RS01260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS01275	COG4585	Histidine kinase
K1516_RS01280	COG2197	response regulator
K1516_RS01295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K1516_RS01305	COG0628	permease
K1516_RS01325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1516_RS01340	COG5507	3-demethylubiquinone-9 3-methyltransferase
K1516_RS01365	COG2814	Major facilitator Superfamily
K1516_RS01370	COG0583	DNA-binding transcription factor activity
K1516_RS01375	COG4807	Protein conserved in bacteria
K1516_RS01380	COG4221	oxidoreductase activity
K1516_RS01390	COG0018	arginyl-trna synthetase
K1516_RS01395	COG2003	Belongs to the UPF0758 family
K1516_RS01400	COG2197	response regulator
K1516_RS01405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K1516_RS01410	COG0756	dUTP diphosphatase activity
K1516_RS01425	COG2205	protein histidine kinase activity
K1516_RS01435	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K1516_RS01440	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K1516_RS01455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K1516_RS01460	COG0708	Exodeoxyribonuclease III
K1516_RS01465	COG2223	nitrite transmembrane transporter activity
K1516_RS01480	COG0739	heme binding
K1516_RS01545	COG2234	aminopeptidase activity
K1516_RS01555	COG4942	peptidase
K1516_RS01560	COG0793	Belongs to the peptidase S41A family
K1516_RS01570	COG2067	long-chain fatty acid transport protein
K1516_RS01595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K1516_RS01640	COG0109	protoheme IX farnesyltransferase activity
K1516_RS01665	COG0358	DNA primase activity
K1516_RS01670	COG1295	ribonuclease BN
K1516_RS01690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K1516_RS01700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K1516_RS01705	COG0668	transmembrane transport
K1516_RS01720	COG2133	pyrroloquinoline quinone binding
K1516_RS01725	COG4682	membrane
K1516_RS01735	COG0531	amino acid
K1516_RS01745	COG1737	Transcriptional regulator
K1516_RS01750	COG4948	Mandelate Racemase Muconate Lactonizing
K1516_RS01805	COG5383	Protein conserved in bacteria
K1516_RS01815	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K1516_RS01820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K1516_RS01845	COG0778	Nitroreductase
K1516_RS01850	COG2353	YceI-like domain
K1516_RS01865	COG2375	cellular response to nickel ion
K1516_RS01905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K1516_RS01915	COG3727	T/G mismatch-specific endonuclease activity
K1516_RS01950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1516_RS02010	COG2267	carboxylic ester hydrolase activity
K1516_RS02075	COG0488	(ABC) transporter
K1516_RS02080	COG0583	DNA-binding transcription factor activity
K1516_RS02090	COG2814	Major facilitator Superfamily
K1516_RS02095	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K1516_RS02100	COG1113	amino acid transport
K1516_RS02105	COG0741	lytic transglycosylase activity
K1516_RS02130	COG2764	glyoxalase bleomycin resistance protein dioxygenase
K1516_RS02140	COG5507	3-demethylubiquinone-9 3-methyltransferase
K1516_RS02145	COG4941	Belongs to the sigma-70 factor family
K1516_RS02155	COG3275	phosphorelay sensor kinase activity
K1516_RS02160	COG3279	Response regulator of the LytR AlgR family
K1516_RS02180	COG1309	transcriptional regulator
K1516_RS02195	COG3590	peptidase
K1516_RS02200	COG5001	Diguanylate cyclase
K1516_RS02205	COG0583	DNA-binding transcription factor activity
K1516_RS02215	COG3384	dioxygenase
K1516_RS02220	COG0025	NhaP-type Na H and K H
K1516_RS02245	COG1360	Flagellar Motor Protein
K1516_RS02275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K1516_RS02290	COG5002	protein histidine kinase activity
K1516_RS02305	COG2813	Specifically methylates the guanine in position
K1516_RS02310	COG1187	pseudouridine synthase activity
K1516_RS02315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K1516_RS02325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K1516_RS02330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K1516_RS02345	COG0583	DNA-binding transcription factor activity
K1516_RS02350	COG2226	methyltransferase
K1516_RS02375	COG1956	GAF domain-containing protein
K1516_RS02380	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K1516_RS02390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1516_RS02395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1516_RS02400	COG0785	Cytochrome C biogenesis protein
K1516_RS02400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K1516_RS02405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1516_RS02410	COG0745	RESPONSE REGULATOR receiver
K1516_RS02415	COG5002	protein histidine kinase activity
K1516_RS02420	COG2205	protein histidine kinase activity
K1516_RS02425	COG0745	RESPONSE REGULATOR receiver
K1516_RS02430	COG0367	asparagine synthase
K1516_RS02440	COG0720	synthase
K1516_RS02455	COG0513	Belongs to the DEAD box helicase family
K1516_RS02465	COG0625	glutathione transferase activity
K1516_RS02495	COG0626	cystathionine gamma-synthase activity
K1516_RS02515	COG0438	transferase activity, transferring glycosyl groups
K1516_RS02515	COG1216	Glycosyl transferase, family 2
K1516_RS02535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K1516_RS02540	COG2076	Multidrug Resistance protein
K1516_RS02555	COG0318	PFAM AMP-dependent synthetase and ligase
K1516_RS02555	COG0204	Acyl-transferase
K1516_RS02560	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS02565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1516_RS02575	COG0463	Glycosyl transferase, family 2
K1516_RS02615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1516_RS02620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K1516_RS02655	COG1127	ABC transporter
K1516_RS02660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K1516_RS02675	COG0442	prolyl-tRNA aminoacylation
K1516_RS02685	COG1183	phosphatidylcholine synthase activity
K1516_RS02695	COG0456	acetyltransferase
K1516_RS02705	COG0525	valine-tRNA ligase activity
K1516_RS02720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K1516_RS02730	COG0795	lipopolysaccharide-transporting ATPase activity
K1516_RS02745	COG4974	Belongs to the 'phage' integrase family
K1516_RS02750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K1516_RS02760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K1516_RS02760	COG0047	phosphoribosylformylglycinamidine synthase activity
K1516_RS02765	COG5295	Hep Hag repeat protein
K1516_RS02770	COG1404	Belongs to the peptidase S8 family
K1516_RS02775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K1516_RS02780	COG1459	type II secretion system
K1516_RS02785	COG2165	general secretion pathway protein
K1516_RS02790	COG4970	Tfp pilus assembly protein FimT
K1516_RS02795	COG2165	general secretion pathway protein
K1516_RS02800	COG4795	General secretion pathway protein
K1516_RS02805	COG3156	type II secretion system protein K
K1516_RS02810	COG3166	PFAM Fimbrial assembly family protein
K1516_RS02825	COG1450	Type ii and iii secretion system protein
K1516_RS02850	COG3539	Fimbrial protein
K1516_RS02855	COG3121	Chaperone
K1516_RS02870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K1516_RS02880	COG1215	transferase activity, transferring glycosyl groups
K1516_RS02895	COG2252	PERMEase
K1516_RS02900	COG0488	(ABC) transporter
K1516_RS02910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K1516_RS02925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K1516_RS02930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1516_RS02930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K1516_RS02990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K1516_RS02995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K1516_RS03020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K1516_RS03020	COG2755	lipolytic protein G-D-S-L family
K1516_RS03025	COG0277	FAD linked oxidase domain protein
K1516_RS03030	COG1988	membrane-bound metal-dependent
K1516_RS03065	COG2001	Belongs to the MraZ family
K1516_RS03070	COG0275	rRNA processing
K1516_RS03075	COG3116	cell division
K1516_RS03085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K1516_RS03090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K1516_RS03105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K1516_RS03110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K1516_RS03115	COG1181	Belongs to the D-alanine--D-alanine ligase family
K1516_RS03120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K1516_RS03130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K1516_RS03135	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K1516_RS03145	COG0739	heme binding
K1516_RS03150	COG0653	protein targeting
K1516_RS03155	COG0494	nUDIX hydrolase
K1516_RS03165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K1516_RS03175	COG3275	phosphorelay sensor kinase activity
K1516_RS03185	COG0402	S-adenosylhomocysteine deaminase activity
K1516_RS03205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K1516_RS03210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K1516_RS03220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K1516_RS03230	COG1607	acyl-coa hydrolase
K1516_RS03235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K1516_RS03255	COG4106	trans-aconitate 2-methyltransferase activity
K1516_RS03260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K1516_RS03280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1516_RS03285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K1516_RS03290	COG0667	Aldo Keto reductase
K1516_RS03300	COG4771	TonB-dependent receptor
K1516_RS03320	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K1516_RS03325	COG4181	ATPase activity
K1516_RS03340	COG0642	Histidine kinase
K1516_RS03350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K1516_RS03355	COG0861	Integral membrane protein TerC family
K1516_RS03360	COG2814	Major facilitator Superfamily
K1516_RS03365	COG1704	LemA family
K1516_RS03380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K1516_RS03385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K1516_RS03395	COG3738	Protein conserved in bacteria
K1516_RS03400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K1516_RS03405	COG2967	ApaG domain
K1516_RS03410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K1516_RS03415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K1516_RS03420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1516_RS03425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K1516_RS03435	COG2096	Adenosyltransferase
K1516_RS03445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1516_RS03450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1516_RS03460	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K1516_RS03480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1516_RS03490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K1516_RS03500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K1516_RS03505	COG0583	DNA-binding transcription factor activity
K1516_RS03510	COG3634	alkyl hydroperoxide reductase activity
K1516_RS03570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K1516_RS03595	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K1516_RS03610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K1516_RS03615	COG1404	Belongs to the peptidase S8 family
K1516_RS03635	COG1295	ribonuclease BN
K1516_RS03640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K1516_RS03655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K1516_RS03660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K1516_RS03675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K1516_RS03685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K1516_RS03690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K1516_RS03695	COG0193	aminoacyl-tRNA hydrolase activity
K1516_RS03700	COG0012	GTP binding
K1516_RS03710	COG2197	response regulator
K1516_RS03715	COG0784	Response regulator, receiver
K1516_RS03715	COG2205	protein histidine kinase activity
K1516_RS03720	COG2203	Gaf domain
K1516_RS03720	COG3706	GGDEF domain
K1516_RS03720	COG4251	negative regulation of phosphorylation
K1516_RS03720	COG5001	Diguanylate cyclase
K1516_RS03725	COG0784	Response regulator, receiver
K1516_RS03725	COG2205	protein histidine kinase activity
K1516_RS03730	COG4206	TonB-dependent receptor
K1516_RS03735	COG4242	Belongs to the peptidase S51 family
K1516_RS03760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K1516_RS03775	COG0250	Participates in transcription elongation, termination and antitermination
K1516_RS03780	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K1516_RS03785	COG0081	regulation of translation
K1516_RS03790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K1516_RS03795	COG0222	ribosome binding
K1516_RS03800	COG0085	RNA polymerase activity
K1516_RS03805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K1516_RS03810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K1516_RS03815	COG0049	tRNA binding
K1516_RS03820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K1516_RS03825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K1516_RS03830	COG0051	transcription antitermination factor activity, RNA binding
K1516_RS03835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K1516_RS03840	COG0088	Forms part of the polypeptide exit tunnel
K1516_RS03845	COG0089	rRNA binding
K1516_RS03850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K1516_RS03855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K1516_RS03860	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K1516_RS03865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K1516_RS03870	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K1516_RS03875	COG0255	Belongs to the universal ribosomal protein uL29 family
K1516_RS03880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K1516_RS03885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K1516_RS03890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K1516_RS03895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K1516_RS03900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K1516_RS03905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K1516_RS03910	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K1516_RS03915	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K1516_RS03920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K1516_RS03925	COG1841	ribosomal large subunit assembly
K1516_RS03930	COG0200	Binds to the 23S rRNA
K1516_RS03935	COG0201	protein transport
K1516_RS03940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K1516_RS03945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K1516_RS03950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K1516_RS03955	COG0202	RNA polymerase activity
K1516_RS03960	COG0203	ribosomal protein L17
K1516_RS03975	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K1516_RS03985	COG0154	amidase activity
K1516_RS04000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K1516_RS04005	COG0039	L-malate dehydrogenase activity
K1516_RS04010	COG0564	pseudouridine synthase activity
K1516_RS04015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K1516_RS04030	COG0625	glutathione transferase activity
K1516_RS04040	COG0446	pyridine nucleotide-disulphide oxidoreductase
K1516_RS04040	COG1902	pentaerythritol trinitrate reductase activity
K1516_RS04045	COG2364	Membrane
K1516_RS04065	COG1187	pseudouridine synthase activity
K1516_RS04085	COG1063	alcohol dehydrogenase
K1516_RS04095	COG0588	phosphoglycerate mutase activity
K1516_RS04100	COG0285	dihydrofolate synthase activity
K1516_RS04120	COG2833	Protein of unknown function (DUF455)
K1516_RS04130	COG3291	Pkd domain containing protein
K1516_RS04135	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K1516_RS04140	COG0671	phosphoesterase, PA-phosphatase related
K1516_RS04145	COG0438	transferase activity, transferring glycosyl groups
K1516_RS04150	COG0248	Ppx GppA phosphatase
K1516_RS04155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K1516_RS04170	COG4783	chaperone-mediated protein folding
K1516_RS04185	COG0473	3-isopropylmalate dehydrogenase activity
K1516_RS04245	COG0544	peptidyl-prolyl cis-trans isomerase activity
K1516_RS04250	COG0740	serine-type endopeptidase activity
K1516_RS04255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K1516_RS04295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1516_RS04300	COG1388	LysM domain
K1516_RS04300	COG3942	CHAP domain
K1516_RS04305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1516_RS04315	COG0328	RNA-DNA hybrid ribonuclease activity
K1516_RS04320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K1516_RS04325	COG0631	protein serine/threonine phosphatase activity
K1516_RS04340	COG0859	PFAM glycosyl transferase family 9
K1516_RS04345	COG3642	lipopolysaccharide core region biosynthetic process
K1516_RS04350	COG1234	tRNA 3'-trailer cleavage
K1516_RS04365	COG2076	Multidrug Resistance protein
K1516_RS04390	COG3209	COG3209 Rhs family protein
K1516_RS04425	COG4695	Portal protein
K1516_RS04435	COG3209	COG3209 Rhs family protein
K1516_RS04445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K1516_RS04450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K1516_RS04460	COG0537	adenosine 5'-monophosphoramidase activity
K1516_RS04480	COG0714	Associated with various cellular activities
K1516_RS04495	COG1399	metal-binding, possibly nucleic acid-binding protein
K1516_RS04500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K1516_RS04505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K1516_RS04515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K1516_RS04530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1516_RS04535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K1516_RS04540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K1516_RS04545	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K1516_RS04710	COG4774	siderophore transport
K1516_RS04720	COG2223	nitrite transmembrane transporter activity
K1516_RS04735	COG2226	methyltransferase
K1516_RS04745	COG0583	DNA-binding transcription factor activity
K1516_RS04750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1516_RS04755	COG0697	spore germination
K1516_RS04760	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS04765	COG0583	DNA-binding transcription factor activity
K1516_RS04775	COG0477	Major facilitator Superfamily
K1516_RS04780	COG2205	protein histidine kinase activity
K1516_RS04790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS04830	COG0583	DNA-binding transcription factor activity
K1516_RS04840	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K1516_RS04860	COG0667	Aldo Keto reductase
K1516_RS04885	COG2818	Glycosylase
K1516_RS04890	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K1516_RS04895	COG1678	Uncharacterized ACR, COG1678
K1516_RS04900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K1516_RS04905	COG0540	Belongs to the ATCase OTCase family
K1516_RS04930	COG2239	Acts as a magnesium transporter
K1516_RS04935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1516_RS04950	COG1660	Displays ATPase and GTPase activities
K1516_RS04955	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K1516_RS04960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1516_RS04965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K1516_RS04975	COG1137	ATPase activity
K1516_RS04990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K1516_RS05005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K1516_RS05025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K1516_RS05045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K1516_RS05055	COG0628	permease
K1516_RS05065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K1516_RS05075	COG2261	transglycosylase associated protein
K1516_RS05085	COG1555	photosystem II stabilization
K1516_RS05105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K1516_RS05110	COG1477	protein flavinylation
K1516_RS05130	COG4771	TonB-dependent receptor
K1516_RS05140	COG3128	pkhd-type hydroxylase
K1516_RS05165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K1516_RS05170	COG0719	Fe-S assembly protein
K1516_RS05175	COG0396	ATPase activity
K1516_RS05180	COG0719	Fe-S assembly protein
K1516_RS05185	COG1959	2 iron, 2 sulfur cluster binding
K1516_RS05215	COG1764	response to oxidative stress
K1516_RS05220	COG0384	phenazine biosynthesis protein PhzF
K1516_RS05225	COG0384	phenazine biosynthesis protein PhzF
K1516_RS05230	COG0527	aspartate kinase activity
K1516_RS05240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K1516_RS05255	COG0142	geranyltranstransferase activity
K1516_RS05260	COG0366	Alpha amylase catalytic
K1516_RS05270	COG1082	Xylose isomerase domain protein TIM barrel
K1516_RS05280	COG2211	Major facilitator Superfamily
K1516_RS05280	COG2190	(PTS) system
K1516_RS05315	COG1131	(ABC) transporter
K1516_RS05320	COG1609	Transcriptional regulator
K1516_RS05330	COG0629	single-stranded DNA binding
K1516_RS05360	COG2010	Cytochrome c
K1516_RS05370	COG0673	inositol 2-dehydrogenase activity
K1516_RS05375	COG2211	Major facilitator Superfamily
K1516_RS05385	COG1609	Transcriptional regulator
K1516_RS05400	COG0583	DNA-binding transcription factor activity
K1516_RS05430	COG0583	DNA-binding transcription factor activity
K1516_RS05435	COG1073	alpha beta
K1516_RS05440	COG1073	alpha beta
K1516_RS05450	COG0640	Transcriptional regulator
K1516_RS05460	COG3655	Transcriptional regulator
K1516_RS05465	COG1253	flavin adenine dinucleotide binding
K1516_RS05470	COG1408	metallophosphoesterase
K1516_RS05485	COG0477	Major facilitator Superfamily
K1516_RS05500	COG1802	Transcriptional regulator
K1516_RS05535	COG3052	prosthetic group binding
K1516_RS05550	COG0579	oxidoreductase
K1516_RS05585	COG3104	oligopeptide transport
K1516_RS05590	COG1297	OPT oligopeptide transporter protein
K1516_RS05595	COG0823	Involved in the tonB-independent uptake of proteins
K1516_RS05595	COG1506	peptidase
K1516_RS05610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K1516_RS05615	COG2894	cell division
K1516_RS05630	COG4585	Histidine kinase
K1516_RS05635	COG2197	response regulator
K1516_RS05675	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K1516_RS05690	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K1516_RS05700	COG1595	DNA-templated transcription, initiation
K1516_RS05710	COG1946	Acyl-CoA thioesterase
K1516_RS05730	COG0824	Thioesterase
K1516_RS05735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K1516_RS05740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K1516_RS05745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K1516_RS05750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K1516_RS05755	COG0268	Binds directly to 16S ribosomal RNA
K1516_RS05760	COG0728	peptidoglycan biosynthetic process
K1516_RS05765	COG0196	riboflavin kinase activity
K1516_RS05770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K1516_RS05780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K1516_RS05795	COG4206	TonB-dependent receptor
K1516_RS05815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K1516_RS05825	COG3209	COG3209 Rhs family protein
K1516_RS05835	COG0582	viral genome integration into host DNA
K1516_RS05885	COG3209	COG3209 Rhs family protein
K1516_RS05905	COG3209	COG3209 Rhs family protein
K1516_RS05930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K1516_RS05935	COG1845	cytochrome c oxidase, subunit III
K1516_RS05940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K1516_RS05955	COG0326	Molecular chaperone. Has ATPase activity
K1516_RS05975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K1516_RS05995	COG0228	four-way junction DNA binding
K1516_RS06000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K1516_RS06005	COG0336	Belongs to the RNA methyltransferase TrmD family
K1516_RS06010	COG0335	large ribosomal subunit rRNA binding
K1516_RS06030	COG0534	Mate efflux family protein
K1516_RS06050	COG0753	catalase activity
K1516_RS06075	COG0840	transmembrane signaling receptor activity
K1516_RS06080	COG3134	Outer membrane lipoprotein
K1516_RS06095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS06120	COG0024	Methionine aminopeptidase
K1516_RS06145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K1516_RS06170	COG1647	Serine aminopeptidase, S33
K1516_RS06200	COG2814	Major facilitator Superfamily
K1516_RS06205	COG3706	GGDEF domain
K1516_RS06225	COG0588	phosphoglycerate mutase activity
K1516_RS06230	COG3590	peptidase
K1516_RS06240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K1516_RS06250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K1516_RS06255	COG0745	RESPONSE REGULATOR receiver
K1516_RS06260	COG2205	protein histidine kinase activity
K1516_RS06265	COG4452	Inner membrane protein CreD
K1516_RS06280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K1516_RS06285	COG0735	belongs to the Fur family
K1516_RS06325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K1516_RS06365	COG5001	Diguanylate cyclase
K1516_RS06365	COG5002	protein histidine kinase activity
K1516_RS06375	COG1187	pseudouridine synthase activity
K1516_RS06385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K1516_RS06410	COG1132	(ABC) transporter
K1516_RS06465	COG1695	Transcriptional regulator
K1516_RS06485	COG1981	membrane
K1516_RS06490	COG0825	malonyl-CoA metabolic process
K1516_RS06515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K1516_RS06525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K1516_RS06530	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K1516_RS06535	COG0750	zinc metalloprotease
K1516_RS06540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K1516_RS06545	COG0575	Belongs to the CDS family
K1516_RS06550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K1516_RS06555	COG0233	cytoplasmic translational termination
K1516_RS06560	COG0528	UMP kinase activity
K1516_RS06570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K1516_RS06575	COG0052	Belongs to the universal ribosomal protein uS2 family
K1516_RS06595	COG3188	usher protein
K1516_RS06615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K1516_RS06630	COG1393	Belongs to the ArsC family
K1516_RS06635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K1516_RS06645	COG0367	asparagine synthase
K1516_RS06650	COG0475	glutathione-regulated potassium exporter activity
K1516_RS06685	COG1566	PFAM secretion protein HlyD family protein
K1516_RS06690	COG2814	Major facilitator Superfamily
K1516_RS06700	COG0583	DNA-binding transcription factor activity
K1516_RS06720	COG0557	exoribonuclease II activity
K1516_RS06730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1516_RS06735	COG1538	Outer membrane efflux protein
K1516_RS06740	COG0577	efflux transmembrane transporter activity
K1516_RS06740	COG1136	(ABC) transporter
K1516_RS06745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS06765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K1516_RS06770	COG2259	Doxx family
K1516_RS06780	COG3220	belongs to the UPF0276 family
K1516_RS06790	COG0704	Plays a role in the regulation of phosphate uptake
K1516_RS06800	COG0581	inorganic phosphate transmembrane transporter activity
K1516_RS06805	COG0573	inorganic phosphate transmembrane transporter activity
K1516_RS06810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K1516_RS06815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K1516_RS06825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K1516_RS06835	COG1024	Enoyl-CoA hydratase
K1516_RS06845	COG0494	nUDIX hydrolase
K1516_RS06865	COG0116	Belongs to the methyltransferase superfamily
K1516_RS06865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K1516_RS06885	COG2733	membrane
K1516_RS06895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K1516_RS06900	COG1012	belongs to the aldehyde dehydrogenase family
K1516_RS06910	COG0477	Major facilitator Superfamily
K1516_RS06915	COG2703	oxygen carrier activity
K1516_RS06945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K1516_RS06955	COG0174	glutamine synthetase
K1516_RS06965	COG2072	flavoprotein involved in K transport
K1516_RS06970	COG3842	ATPase activity
K1516_RS06975	COG1176	ABC-type spermidine putrescine transport system, permease component I
K1516_RS06980	COG1177	transmembrane transport
K1516_RS06985	COG1012	belongs to the aldehyde dehydrogenase family
K1516_RS07000	COG4535	Mg2 and Co2 transporter CorC
K1516_RS07015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K1516_RS07020	COG1702	phosphate starvation-inducible protein PhoH
K1516_RS07030	COG1131	(ABC) transporter
K1516_RS07035	COG0842	Transport permease protein
K1516_RS07040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1516_RS07055	COG0741	lytic transglycosylase activity
K1516_RS07060	COG0723	plastoquinol--plastocyanin reductase activity
K1516_RS07065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K1516_RS07070	COG2857	Cytochrome c1
K1516_RS07075	COG0625	glutathione transferase activity
K1516_RS07080	COG2969	positive regulation of protein catabolic process
K1516_RS07115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K1516_RS07125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K1516_RS07140	COG1611	Belongs to the LOG family
K1516_RS07185	COG0556	nucleotide-excision repair
K1516_RS07215	COG3713	MltA-interacting MipA family protein
K1516_RS07235	COG0811	peptide transport
K1516_RS07250	COG1663	tetraacyldisaccharide 4'-kinase activity
K1516_RS07255	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K1516_RS07260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K1516_RS07270	COG0322	excinuclease ABC activity
K1516_RS07305	COG1136	(ABC) transporter
K1516_RS07305	COG0577	efflux transmembrane transporter activity
K1516_RS07495	COG0740	serine-type endopeptidase activity
K1516_RS07610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K1516_RS07635	COG0583	DNA-binding transcription factor activity
K1516_RS07655	COG1917	Cupin 2, conserved barrel domain protein
K1516_RS07655	COG4977	sequence-specific DNA binding
K1516_RS07660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K1516_RS07680	COG0348	domain, Protein
K1516_RS07695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K1516_RS07720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K1516_RS07725	COG0069	glutamate synthase activity
K1516_RS07755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1516_RS07770	COG1253	flavin adenine dinucleotide binding
K1516_RS07790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1516_RS07805	COG0504	CTP synthase activity
K1516_RS07810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K1516_RS07825	COG0148	phosphopyruvate hydratase activity
K1516_RS07830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K1516_RS07835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K1516_RS07840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K1516_RS07850	COG2840	Smr protein MutS2
K1516_RS07855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K1516_RS07860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K1516_RS07870	COG1388	LysM domain
K1516_RS07870	COG4942	peptidase
K1516_RS07885	COG1534	Rna-binding protein
K1516_RS07890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K1516_RS07895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K1516_RS07905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K1516_RS07910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K1516_RS07915	COG1923	regulation of RNA biosynthetic process
K1516_RS07920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K1516_RS07925	COG1546	Belongs to the CinA family
K1516_RS07930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K1516_RS07935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K1516_RS07940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K1516_RS07945	COG2137	regulation of response to DNA damage stimulus
K1516_RS07950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K1516_RS07955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K1516_RS07980	COG4773	Receptor
K1516_RS07995	COG1940	carbohydrate kinase activity
K1516_RS08035	COG3540	Alkaline phosphatase
K1516_RS08055	COG3258	Cytochrome c
K1516_RS08070	COG2223	nitrite transmembrane transporter activity
K1516_RS08085	COG1741	Belongs to the pirin family
K1516_RS08090	COG0583	DNA-binding transcription factor activity
K1516_RS08115	COG0351	phosphomethylpyrimidine kinase
K1516_RS08115	COG0352	thiamine-phosphate diphosphorylase activity
K1516_RS08130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K1516_RS08135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K1516_RS08145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K1516_RS08155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K1516_RS08160	COG0477	Major facilitator Superfamily
K1516_RS08170	COG0617	tRNA 3'-terminal CCA addition
K1516_RS08180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K1516_RS08185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K1516_RS08195	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K1516_RS08200	COG0166	Belongs to the GPI family
K1516_RS08205	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K1516_RS08215	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K1516_RS08220	COG0671	phosphoesterase, PA-phosphatase related
K1516_RS08230	COG0800	Aldolase
K1516_RS08235	COG0129	dihydroxy-acid dehydratase activity
K1516_RS08245	COG0837	glucose binding
K1516_RS08250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K1516_RS08270	COG2009	succinate dehydrogenase
K1516_RS08275	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K1516_RS08280	COG1053	succinate dehydrogenase
K1516_RS08300	COG4591	ABC-type transport system involved in lipoprotein release permease component
K1516_RS08315	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K1516_RS08325	COG0552	protein localization to endoplasmic reticulum
K1516_RS08340	COG0742	ribosomal rna small subunit methyltransferase
K1516_RS08345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K1516_RS08355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K1516_RS08360	COG0405	Gamma-glutamyltransferase
K1516_RS08365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1516_RS08385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K1516_RS08405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K1516_RS08410	COG0415	Belongs to the DNA photolyase family
K1516_RS08415	COG2885	chlorophyll binding
K1516_RS08420	COG0583	DNA-binding transcription factor activity
K1516_RS08520	COG1404	Belongs to the peptidase S8 family
K1516_RS08600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K1516_RS08615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K1516_RS08620	COG0735	belongs to the Fur family
K1516_RS08630	COG0583	DNA-binding transcription factor activity
K1516_RS08635	COG0497	DNA recombination
K1516_RS08640	COG1420	regulation of RNA biosynthetic process
K1516_RS08645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K1516_RS08650	COG0443	Heat shock 70 kDa protein
K1516_RS08655	COG0484	heat shock protein binding
K1516_RS08660	COG2207	Transcriptional regulator
K1516_RS08665	COG2223	nitrite transmembrane transporter activity
K1516_RS08680	COG1605	Chorismate mutase
K1516_RS08680	COG0287	Prephenate dehydrogenase
K1516_RS08690	COG1132	(ABC) transporter
K1516_RS08720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K1516_RS08725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K1516_RS08730	COG0343	queuine tRNA-ribosyltransferase activity
K1516_RS08735	COG1862	Preprotein translocase
K1516_RS08745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K1516_RS08750	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K1516_RS08760	COG2081	HI0933 family
K1516_RS08765	COG4681	YaeQ
K1516_RS08770	COG0564	pseudouridine synthase activity
K1516_RS08785	COG0625	glutathione transferase activity
K1516_RS08790	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K1516_RS08795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K1516_RS08800	COG0513	Belongs to the DEAD box helicase family
K1516_RS08810	COG0583	DNA-binding transcription factor activity
K1516_RS08815	COG0488	(ABC) transporter
K1516_RS08840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS08855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1516_RS08860	COG2957	Belongs to the agmatine deiminase family
K1516_RS08870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K1516_RS08875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K1516_RS08885	COG0776	regulation of translation
K1516_RS08895	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K1516_RS08900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K1516_RS08910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K1516_RS08915	COG0183	Belongs to the thiolase family
K1516_RS08920	COG1024	Enoyl-CoA hydratase
K1516_RS08920	COG1250	3-hydroxyacyl-CoA dehydrogenase
K1516_RS08930	COG0105	UTP biosynthetic process
K1516_RS08935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K1516_RS08955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K1516_RS08960	COG1160	GTP binding
K1516_RS08985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K1516_RS08990	COG0475	glutathione-regulated potassium exporter activity
K1516_RS08990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K1516_RS09010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K1516_RS09010	COG0519	Catalyzes the synthesis of GMP from XMP
K1516_RS09075	COG0583	DNA-binding transcription factor activity
K1516_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS09130	COG0640	Transcriptional regulator
K1516_RS09145	COG4716	Myosin-crossreactive antigen
K1516_RS09165	COG0431	NADPH-dependent FMN reductase
K1516_RS09175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1516_RS09180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1516_RS09185	COG1473	amidohydrolase
K1516_RS09200	COG1126	abc transporter atp-binding protein
K1516_RS09205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K1516_RS09230	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K1516_RS09235	COG0583	DNA-binding transcription factor activity
K1516_RS09240	COG0477	Major facilitator Superfamily
K1516_RS09245	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS09255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K1516_RS09275	COG1309	transcriptional regulator
K1516_RS09290	COG0697	spore germination
K1516_RS09295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K1516_RS09300	COG0167	dihydroorotate dehydrogenase activity
K1516_RS09315	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS09320	COG1012	belongs to the aldehyde dehydrogenase family
K1516_RS09330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K1516_RS09335	COG0489	protein tyrosine kinase activity
K1516_RS09335	COG3206	protein involved in exopolysaccharide biosynthesis
K1516_RS09340	COG2244	polysaccharide biosynthetic process
K1516_RS09345	COG0438	transferase activity, transferring glycosyl groups
K1516_RS09365	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K1516_RS09380	COG1596	polysaccharide export
K1516_RS09405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K1516_RS09435	COG0745	RESPONSE REGULATOR receiver
K1516_RS09440	COG4191	Histidine kinase
K1516_RS09440	COG0784	Response regulator, receiver
K1516_RS09445	COG3437	response regulator, receiver
K1516_RS09445	COG3850	Histidine kinase
K1516_RS09445	COG4999	Histidine kinase
K1516_RS09445	COG2205	protein histidine kinase activity
K1516_RS09450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K1516_RS09460	COG5002	protein histidine kinase activity
K1516_RS09470	COG0640	Transcriptional regulator
K1516_RS09510	COG0527	aspartate kinase activity
K1516_RS09510	COG0460	homoserine dehydrogenase
K1516_RS09515	COG0083	homoserine kinase activity
K1516_RS09525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K1516_RS09530	COG0124	histidyl-tRNA synthetase
K1516_RS09545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K1516_RS09550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K1516_RS09555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K1516_RS09560	COG0131	Imidazoleglycerol-phosphate dehydratase
K1516_RS09560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K1516_RS09565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K1516_RS09570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K1516_RS09575	COG0107	imidazoleglycerol-phosphate synthase activity
K1516_RS09580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K1516_RS09580	COG0140	phosphoribosyl-ATP diphosphatase activity
K1516_RS09600	COG1446	asparaginase
K1516_RS09605	COG3142	Participates in the control of copper homeostasis
K1516_RS09620	COG0789	Transcriptional regulator
K1516_RS09635	COG3537	Alpha-1,2-mannosidase
K1516_RS09640	COG1609	Transcriptional regulator
K1516_RS09650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1516_RS09665	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K1516_RS09670	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K1516_RS09675	COG0235	Class ii aldolase
K1516_RS09680	COG0531	amino acid
K1516_RS09685	COG0531	amino acid
K1516_RS09695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K1516_RS09700	COG0277	FAD linked oxidase domain protein
K1516_RS09715	COG2205	protein histidine kinase activity
K1516_RS09720	COG0745	RESPONSE REGULATOR receiver
K1516_RS09725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS09730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS09745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K1516_RS09790	COG2249	NAD(P)H dehydrogenase (quinone) activity
K1516_RS09805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K1516_RS09810	COG0505	Belongs to the CarA family
K1516_RS09815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K1516_RS09820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K1516_RS09830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K1516_RS09850	COG3209	COG3209 Rhs family protein
K1516_RS09880	COG4676	Protein conserved in bacteria
K1516_RS09895	COG3279	Response regulator of the LytR AlgR family
K1516_RS09900	COG0501	Belongs to the peptidase M48B family
K1516_RS09915	COG1012	belongs to the aldehyde dehydrogenase family
K1516_RS09935	COG0784	Response regulator, receiver
K1516_RS09935	COG2205	protein histidine kinase activity
K1516_RS09935	COG2198	Histidine kinase
K1516_RS09940	COG1024	Enoyl-CoA hydratase
K1516_RS09945	COG0318	PFAM AMP-dependent synthetase and ligase
K1516_RS09950	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K1516_RS09955	COG1012	belongs to the aldehyde dehydrogenase family
K1516_RS09960	COG1309	transcriptional regulator
K1516_RS09965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K1516_RS10005	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K1516_RS10015	COG0840	transmembrane signaling receptor activity
K1516_RS10020	COG0840	transmembrane signaling receptor activity
K1516_RS10030	COG0835	chemotaxis
K1516_RS10035	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K1516_RS10040	COG0840	transmembrane signaling receptor activity
K1516_RS10050	COG0745	RESPONSE REGULATOR receiver
K1516_RS10060	COG0835	chemotaxis
K1516_RS10070	COG1360	Flagellar Motor Protein
K1516_RS10075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K1516_RS10080	COG0643	Histidine kinase
K1516_RS10080	COG0784	Response regulator, receiver
K1516_RS10080	COG2198	Histidine kinase
K1516_RS10085	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K1516_RS10110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1516_RS10115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K1516_RS10130	COG1987	bacterial-type flagellum assembly
K1516_RS10140	COG3190	flagellar
K1516_RS10190	COG1677	Flagellar hook-basal body complex protein FliE
K1516_RS10215	COG2197	response regulator
K1516_RS10235	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K1516_RS10275	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K1516_RS10285	COG4787	bacterial-type flagellum-dependent cell motility
K1516_RS10305	COG1815	bacterial-type flagellum-dependent cell motility
K1516_RS10310	COG0784	Response regulator, receiver
K1516_RS10310	COG0835	chemotaxis
K1516_RS10330	COG5002	protein histidine kinase activity
K1516_RS10370	COG2915	High frequency lysogenization protein hflD homolog
K1516_RS10375	COG0482	sulfurtransferase activity
K1516_RS10390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K1516_RS10400	COG0542	response to heat
K1516_RS10435	COG0492	ferredoxin-NADP+ reductase activity
K1516_RS10440	COG1674	ftsk spoiiie
K1516_RS10455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K1516_RS10470	COG2819	hydrolase of the alpha beta superfamily
K1516_RS10480	COG4558	Periplasmic binding protein
K1516_RS10485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1516_RS10490	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K1516_RS10505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K1516_RS10520	COG0784	Response regulator, receiver
K1516_RS10520	COG2198	Histidine kinase
K1516_RS10520	COG2205	protein histidine kinase activity
K1516_RS10535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K1516_RS10545	COG0577	efflux transmembrane transporter activity
K1516_RS10545	COG1136	(ABC) transporter
K1516_RS10570	COG4106	trans-aconitate 2-methyltransferase activity
K1516_RS10585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K1516_RS10595	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
K1516_RS10610	COG1595	DNA-templated transcription, initiation
K1516_RS10630	COG0784	Response regulator, receiver
K1516_RS10635	COG4251	negative regulation of phosphorylation
K1516_RS10645	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K1516_RS10655	COG1073	alpha beta
K1516_RS10660	COG0300	oxidoreductase activity
K1516_RS10680	COG1073	alpha beta
K1516_RS10685	COG1064	alcohol dehydrogenase
K1516_RS10690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1516_RS10705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K1516_RS10710	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS10730	COG1566	PFAM secretion protein HlyD family protein
K1516_RS10740	COG1252	NADH dehydrogenase
K1516_RS10750	COG0454	-acetyltransferase
K1516_RS10750	COG0456	acetyltransferase
K1516_RS10760	COG2259	Doxx family
K1516_RS10765	COG0583	DNA-binding transcription factor activity
K1516_RS10770	COG1741	Belongs to the pirin family
K1516_RS10785	COG5001	Diguanylate cyclase
K1516_RS10800	COG2814	Major facilitator Superfamily
K1516_RS10820	COG0739	heme binding
K1516_RS10980	COG1764	response to oxidative stress
K1516_RS10990	COG0583	DNA-binding transcription factor activity
K1516_RS11010	COG1595	DNA-templated transcription, initiation
K1516_RS11015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K1516_RS11025	COG1309	transcriptional regulator
K1516_RS11045	COG0583	DNA-binding transcription factor activity
K1516_RS11060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1516_RS11065	COG0583	DNA-binding transcription factor activity
K1516_RS11095	COG0583	DNA-binding transcription factor activity
K1516_RS11110	COG1609	Transcriptional regulator
K1516_RS11115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K1516_RS11115	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K1516_RS11120	COG1105	Belongs to the carbohydrate kinase PfkB family
K1516_RS11125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1516_RS11125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K1516_RS11150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K1516_RS11155	COG0583	DNA-binding transcription factor activity
K1516_RS11170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K1516_RS11195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K1516_RS11200	COG1132	(ABC) transporter
K1516_RS11220	COG4555	ABC transporter
K1516_RS11245	COG2207	Transcriptional regulator
K1516_RS11260	COG0596	Alpha beta hydrolase
K1516_RS11270	COG0642	Histidine kinase
K1516_RS11280	COG0318	PFAM AMP-dependent synthetase and ligase
K1516_RS11310	COG1404	Belongs to the peptidase S8 family
K1516_RS11330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K1516_RS11340	COG0346	lactoylglutathione lyase activity
K1516_RS11350	COG2204	response regulator
K1516_RS11420	COG5001	Diguanylate cyclase
K1516_RS11420	COG3447	MASE1 domain protein
K1516_RS11420	COG5002	protein histidine kinase activity
K1516_RS11430	COG0577	efflux transmembrane transporter activity
K1516_RS11430	COG1136	(ABC) transporter
K1516_RS11435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS11445	COG0745	RESPONSE REGULATOR receiver
K1516_RS11450	COG2205	protein histidine kinase activity
K1516_RS11470	COG4774	siderophore transport
K1516_RS11490	COG3214	Protein conserved in bacteria
K1516_RS11500	COG4774	siderophore transport
K1516_RS11555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K1516_RS11560	COG1285	pathogenesis
K1516_RS11565	COG4191	Histidine kinase
K1516_RS11570	COG4566	intracellular signal transduction
K1516_RS11620	COG0243	molybdopterin cofactor binding
K1516_RS11625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K1516_RS11645	COG0477	Major facilitator Superfamily
K1516_RS11670	COG1136	(ABC) transporter
K1516_RS11685	COG4771	TonB-dependent receptor
K1516_RS11705	COG0745	RESPONSE REGULATOR receiver
K1516_RS11715	COG0583	DNA-binding transcription factor activity
K1516_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS11755	COG3537	Alpha-1,2-mannosidase
K1516_RS11775	COG0477	Major facilitator Superfamily
K1516_RS11790	COG2202	Pas domain
K1516_RS11790	COG3920	Histidine kinase
K1516_RS11835	COG1335	isochorismatase
K1516_RS11840	COG1335	isochorismatase
K1516_RS11855	COG0488	(ABC) transporter
K1516_RS11880	COG0811	peptide transport
K1516_RS12000	COG0840	transmembrane signaling receptor activity
K1516_RS12025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K1516_RS12030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K1516_RS12035	COG1120	ATPase activity
K1516_RS12050	COG4149	molybdate abc transporter
K1516_RS12055	COG0725	ABC transporter, periplasmic molybdate-binding protein
K1516_RS12060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K1516_RS12075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K1516_RS12080	COG2181	nitrate reductase activity
K1516_RS12085	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
K1516_RS12090	COG1140	nitrate reductase beta subunit
K1516_RS12095	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K1516_RS12100	COG2223	nitrite transmembrane transporter activity
K1516_RS12110	COG0746	molybdenum cofactor guanylyltransferase activity
K1516_RS12115	COG0314	molybdopterin synthase activity
K1516_RS12125	COG0303	'Molybdopterin
K1516_RS12130	COG0315	cyclic pyranopterin monophosphate synthase activity
K1516_RS12130	COG0521	Mo-molybdopterin cofactor biosynthetic process
K1516_RS12135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K1516_RS12160	COG0789	Transcriptional regulator
K1516_RS12165	COG0431	NADPH-dependent FMN reductase
K1516_RS12175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K1516_RS12180	COG0798	PFAM Bile acid sodium symporter
K1516_RS12255	COG1943	Transposase
K1516_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS12270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K1516_RS12270	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K1516_RS12275	COG3433	isochorismatase activity
K1516_RS12275	COG1535	isochorismatase
K1516_RS12280	COG1535	isochorismatase
K1516_RS12280	COG3433	isochorismatase activity
K1516_RS12285	COG1021	2,3-dihydroxybenzoate-AMP ligase
K1516_RS12290	COG1169	isochorismate synthase
K1516_RS12300	COG2409	Drug exporters of the RND superfamily
K1516_RS12305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K1516_RS12370	COG1914	H( )-stimulated, divalent metal cation uptake system
K1516_RS12385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1516_RS12390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K1516_RS12400	COG4206	TonB-dependent receptor
K1516_RS12405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K1516_RS12450	COG4772	TonB-dependent receptor
K1516_RS12470	COG2226	methyltransferase
K1516_RS12515	COG4964	Belongs to the GSP D family
K1516_RS12570	COG2814	Major facilitator Superfamily
K1516_RS12580	COG1228	amidohydrolase
K1516_RS12590	COG1335	isochorismatase
K1516_RS12605	COG3850	Histidine kinase
K1516_RS12610	COG2197	response regulator
K1516_RS12615	COG4946	Tricorn protease homolog
K1516_RS12615	COG1506	peptidase
K1516_RS12615	COG0823	Involved in the tonB-independent uptake of proteins
K1516_RS12620	COG2201	protein-glutamate methylesterase activity
K1516_RS12625	COG3275	phosphorelay sensor kinase activity
K1516_RS12630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K1516_RS12640	COG0583	DNA-binding transcription factor activity
K1516_RS12655	COG3161	chorismate lyase activity
K1516_RS12745	COG2885	chlorophyll binding
K1516_RS12940	COG0277	FAD linked oxidase domain protein
K1516_RS12945	COG1304	FMN binding
K1516_RS12950	COG2186	Transcriptional regulator
K1516_RS12990	COG0477	Major facilitator Superfamily
K1516_RS13045	COG0587	DNA-directed DNA polymerase activity
K1516_RS13060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K1516_RS13065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K1516_RS13065	COG0519	Catalyzes the synthesis of GMP from XMP
K1516_RS13085	COG1595	DNA-templated transcription, initiation
K1516_RS13095	COG4206	TonB-dependent receptor
K1516_RS13095	COG1629	transport
K1516_RS13120	COG0531	amino acid
K1516_RS13135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K1516_RS13145	COG0789	Transcriptional regulator
K1516_RS13235	COG5002	protein histidine kinase activity
K1516_RS13235	COG3447	MASE1 domain protein
K1516_RS13235	COG5001	Diguanylate cyclase
K1516_RS13240	COG2183	response to ionizing radiation
K1516_RS13265	COG3243	poly(R)-hydroxyalkanoic acid synthase
K1516_RS13285	COG0534	Mate efflux family protein
K1516_RS13305	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K1516_RS13315	COG0668	transmembrane transport
K1516_RS13320	COG1902	pentaerythritol trinitrate reductase activity
K1516_RS13330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K1516_RS13340	COG1733	regulation of RNA biosynthetic process
K1516_RS13350	COG0456	acetyltransferase
K1516_RS13375	COG2814	Major facilitator Superfamily
K1516_RS13405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1516_RS13425	COG0745	RESPONSE REGULATOR receiver
K1516_RS13445	COG0577	efflux transmembrane transporter activity
K1516_RS13445	COG1136	(ABC) transporter
K1516_RS13470	COG0210	DNA helicase
K1516_RS13490	COG0583	DNA-binding transcription factor activity
K1516_RS13495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K1516_RS13505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K1516_RS13520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K1516_RS13525	COG0077	Prephenate dehydratase
K1516_RS13525	COG1605	Chorismate mutase
K1516_RS13530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K1516_RS13570	COG1228	amidohydrolase
K1516_RS13585	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K1516_RS13640	COG2957	Belongs to the agmatine deiminase family
K1516_RS13645	COG0583	DNA-binding transcription factor activity
K1516_RS13690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K1516_RS13710	COG4993	Dehydrogenase
K1516_RS13720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K1516_RS13740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K1516_RS13745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K1516_RS13765	COG0359	binds to the 23S rRNA
K1516_RS13770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K1516_RS13775	COG0360	Binds together with S18 to 16S ribosomal RNA
K1516_RS13785	COG0316	Belongs to the HesB IscA family
K1516_RS13790	COG0017	Asparaginyl-tRNA synthetase
K1516_RS13810	COG0288	reversible hydration of carbon dioxide
K1516_RS13820	COG3844	kynureninase activity
K1516_RS13825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1516_RS13830	COG2925	Exonuclease
K1516_RS13840	COG0667	Aldo Keto reductase
K1516_RS13860	COG2902	Dehydrogenase
K1516_RS13870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS13875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS13885	COG1960	acyl-CoA dehydrogenase activity
K1516_RS13900	COG0646	methionine synthase
K1516_RS13900	COG1410	methionine synthase
K1516_RS13910	COG2755	lipolytic protein G-D-S-L family
K1516_RS13910	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K1516_RS13920	COG2900	Belongs to the SlyX family
K1516_RS13935	COG0386	Belongs to the glutathione peroxidase family
K1516_RS13940	COG1725	Transcriptional regulator
K1516_RS13945	COG1131	(ABC) transporter
K1516_RS13970	COG0114	fumarate hydratase activity
K1516_RS13980	COG2850	peptidyl-arginine hydroxylation
K1516_RS13990	COG0567	Dehydrogenase, E1 component
K1516_RS14005	COG0583	DNA-binding transcription factor activity
K1516_RS14025	COG3540	Alkaline phosphatase
K1516_RS14035	COG0305	Participates in initiation and elongation during chromosome replication
K1516_RS14055	COG0625	glutathione transferase activity
K1516_RS14075	COG0084	hydrolase, TatD family'
K1516_RS14080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K1516_RS14110	COG1393	Belongs to the ArsC family
K1516_RS14115	COG0625	glutathione transferase activity
K1516_RS14130	COG1595	DNA-templated transcription, initiation
K1516_RS14135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K1516_RS14155	COG0386	Belongs to the glutathione peroxidase family
K1516_RS14160	COG0339	signal peptide processing
K1516_RS14165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K1516_RS14185	COG0705	Rhomboid family
K1516_RS14190	COG3104	oligopeptide transport
K1516_RS14200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K1516_RS14205	COG4290	ribonuclease
K1516_RS14220	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K1516_RS14220	COG0316	Belongs to the HesB IscA family
K1516_RS14225	COG2154	pterin-4-alpha-carbinolamine dehydratase
K1516_RS14235	COG0428	transporter
K1516_RS14245	COG1530	ribonuclease E activity
K1516_RS14260	COG0395	ABC-type sugar transport system, permease component
K1516_RS14290	COG0271	Belongs to the BolA IbaG family
K1516_RS14295	COG2350	Protein conserved in bacteria
K1516_RS14300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K1516_RS14305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K1516_RS14310	COG1187	pseudouridine synthase activity
K1516_RS14320	COG2814	Major facilitator Superfamily
K1516_RS14345	COG0436	Aminotransferase
K1516_RS14350	COG4133	protoheme IX ABC transporter activity
K1516_RS14370	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K1516_RS14385	COG3088	subunit of a heme lyase
K1516_RS14385	COG4235	cytochrome complex assembly
K1516_RS14395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K1516_RS14405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K1516_RS14410	COG4988	ABC transporter
K1516_RS14420	COG1294	oxidase, subunit
K1516_RS14475	COG1649	PFAM Uncharacterised BCR, COG1649
K1516_RS14475	COG0726	polysaccharide deacetylase
K1516_RS14480	COG1215	transferase activity, transferring glycosyl groups
K1516_RS14490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K1516_RS14505	COG0165	Argininosuccinate lyase
K1516_RS14510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K1516_RS14520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K1516_RS14525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K1516_RS14530	COG0137	argininosuccinate synthase activity
K1516_RS14535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K1516_RS14550	COG2166	iron-sulfur cluster assembly
K1516_RS14570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K1516_RS14595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K1516_RS14600	COG0402	S-adenosylhomocysteine deaminase activity
K1516_RS14605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K1516_RS14610	COG1509	lysine 2,3-aminomutase activity
K1516_RS14615	COG3300	MHYT domain
K1516_RS14615	COG5001	Diguanylate cyclase
K1516_RS14635	COG0501	Belongs to the peptidase M48B family
K1516_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS14665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K1516_RS14670	COG0860	N-Acetylmuramoyl-L-alanine amidase
K1516_RS14675	COG0802	atpase or kinase
K1516_RS14680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K1516_RS14680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K1516_RS14685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K1516_RS14690	COG1570	exodeoxyribonuclease VII activity
K1516_RS14700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K1516_RS14715	COG4771	TonB-dependent receptor
K1516_RS14720	COG1309	transcriptional regulator
K1516_RS14765	COG2169	Transcriptional regulator
K1516_RS14765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K1516_RS14770	COG2130	NADP-dependent
K1516_RS14795	COG1960	acyl-CoA dehydrogenase activity
K1516_RS14805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K1516_RS14835	COG1309	transcriptional regulator
K1516_RS14840	COG2076	Multidrug Resistance protein
K1516_RS14845	COG5487	UPF0391 membrane protein
K1516_RS14850	COG1280	lysine exporter protein (LysE YggA)
K1516_RS14855	COG0740	serine-type endopeptidase activity
K1516_RS14870	COG1794	racemase activity, acting on amino acids and derivatives
K1516_RS14910	COG0776	regulation of translation
K1516_RS14920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K1516_RS14925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K1516_RS14930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K1516_RS14935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K1516_RS14940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K1516_RS14975	COG1185	polyribonucleotide nucleotidyltransferase activity
K1516_RS14980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K1516_RS14990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K1516_RS14995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K1516_RS15000	COG0195	Participates in both transcription termination and antitermination
K1516_RS15005	COG0779	Required for maturation of 30S ribosomal subunits
K1516_RS15020	COG1007	ATP synthesis coupled electron transport
K1516_RS15035	COG0713	ATP synthesis coupled electron transport
K1516_RS15045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1516_RS15050	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K1516_RS15065	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K1516_RS15070	COG0649	NAD binding
K1516_RS15075	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1516_RS15080	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1516_RS15085	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K1516_RS15100	COG0149	triose-phosphate isomerase activity
K1516_RS15110	COG3083	sulfuric ester hydrolase activity
K1516_RS15115	COG0438	transferase activity, transferring glycosyl groups
K1516_RS15120	COG0726	polysaccharide deacetylase
K1516_RS15125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K1516_RS15135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K1516_RS15140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K1516_RS15145	COG0159	tryptophan synthase activity
K1516_RS15155	COG0133	tryptophan synthase activity
K1516_RS15190	COG0135	phosphoribosylanthranilate isomerase activity
K1516_RS15195	COG0101	tRNA pseudouridine synthase activity
K1516_RS15210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K1516_RS15215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K1516_RS15220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K1516_RS15225	COG2890	protein-(glutamine-N5) methyltransferase activity
K1516_RS15230	COG1999	signal sequence binding
K1516_RS15235	COG0688	phosphatidylethanolamine metabolic process
K1516_RS15250	COG0433	COG0433 Predicted ATPase
K1516_RS15255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K1516_RS15265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K1516_RS15270	COG0412	Dienelactone hydrolase
K1516_RS15285	COG0717	Belongs to the dCTP deaminase family
K1516_RS15290	COG0489	protein tyrosine kinase activity
K1516_RS15295	COG4771	TonB-dependent receptor
K1516_RS15300	COG4771	TonB-dependent receptor
K1516_RS15305	COG3590	peptidase
K1516_RS15345	COG0697	spore germination
K1516_RS15355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K1516_RS15360	COG2311	Membrane
K1516_RS15365	COG1047	Peptidyl-prolyl cis-trans
K1516_RS15370	COG0791	NLP P60 protein
K1516_RS15375	COG0791	NLP P60 protein
K1516_RS15380	COG1301	dicarboxylic acid transport
K1516_RS15400	COG1722	exodeoxyribonuclease VII activity
K1516_RS15405	COG0142	geranyltranstransferase activity
K1516_RS15415	COG0312	modulator of DNA gyrase
K1516_RS15420	COG3028	Belongs to the UPF0307 family
K1516_RS15425	COG0312	modulator of DNA gyrase
K1516_RS15445	COG2968	Membrane
K1516_RS15455	COG4771	TonB-dependent receptor
K1516_RS15465	COG0657	acetylesterase activity
K1516_RS15465	COG2755	lipolytic protein G-D-S-L family
K1516_RS15475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K1516_RS15485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K1516_RS15500	COG0495	leucyl-tRNA aminoacylation
K1516_RS15510	COG3118	belongs to the thioredoxin family
K1516_RS15520	COG3706	GGDEF domain
K1516_RS15520	COG2203	Gaf domain
K1516_RS15520	COG4251	negative regulation of phosphorylation
K1516_RS15520	COG5001	Diguanylate cyclase
K1516_RS15540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K1516_RS15550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K1516_RS15555	COG0346	lactoylglutathione lyase activity
K1516_RS15565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1516_RS15565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K1516_RS15575	COG2878	Part of a membrane complex involved in electron transport
K1516_RS15580	COG0251	oxidation-reduction process
K1516_RS15615	COG2824	Alkylphosphonate utilization operon protein PhnA
K1516_RS15620	COG0443	Heat shock 70 kDa protein
K1516_RS15660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K1516_RS15665	COG3122	Protein conserved in bacteria
K1516_RS15670	COG1451	nucleotide metabolic process
K1516_RS15680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K1516_RS15700	COG0183	Belongs to the thiolase family
K1516_RS15715	COG1960	acyl-CoA dehydrogenase activity
K1516_RS15725	COG1793	dna ligase
K1516_RS15730	COG1201	RNA secondary structure unwinding
K1516_RS15745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K1516_RS15750	COG1278	Cold shock
K1516_RS15755	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K1516_RS15760	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K1516_RS15765	COG1472	Belongs to the glycosyl hydrolase 3 family
K1516_RS15770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K1516_RS15775	COG2954	triphosphatase activity
K1516_RS15780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K1516_RS15785	COG0745	RESPONSE REGULATOR receiver
K1516_RS15790	COG1381	Involved in DNA repair and RecF pathway recombination
K1516_RS15795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K1516_RS15810	COG0681	Belongs to the peptidase S26 family
K1516_RS15815	COG0481	GTPase activity
K1516_RS15820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1516_RS15840	COG1741	Belongs to the pirin family
K1516_RS15845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K1516_RS15855	COG1741	Belongs to the pirin family
K1516_RS15860	COG1966	Carbon starvation protein
K1516_RS15865	COG2879	small protein
K1516_RS15880	COG2205	protein histidine kinase activity
K1516_RS15920	COG2814	Major facilitator Superfamily
K1516_RS15925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K1516_RS15925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K1516_RS15935	COG1113	amino acid transport
K1516_RS15940	COG1917	Cupin 2, conserved barrel domain protein
K1516_RS15940	COG2207	Transcriptional regulator
K1516_RS15965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K1516_RS15975	COG0330	HflC and HflK could
K1516_RS15980	COG0330	HflC and HflK could
K1516_RS15985	COG0604	alcohol dehydrogenase
K1516_RS16000	COG0678	peroxiredoxin activity
K1516_RS16010	COG4953	penicillin-binding protein 1C
K1516_RS16015	COG2373	Large extracellular alpha-helical protein
K1516_RS16020	COG2079	MmgE PrpD family protein
K1516_RS16025	COG2828	Protein conserved in bacteria
K1516_RS16035	COG3609	addiction module antidote protein, CC2985 family
K1516_RS16055	COG3829	transcription factor binding
K1516_RS16070	COG0259	pyridoxamine-phosphate oxidase activity
K1516_RS16085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K1516_RS16105	COG0477	Major facilitator Superfamily
K1516_RS16110	COG5002	protein histidine kinase activity
K1516_RS16110	COG2198	Histidine kinase
K1516_RS16110	COG0784	Response regulator, receiver
K1516_RS16125	COG3038	cytochrome b561
K1516_RS16140	COG1760	l-serine dehydratase
K1516_RS16145	COG2267	carboxylic ester hydrolase activity
K1516_RS16150	COG0527	aspartate kinase activity
K1516_RS16150	COG0460	homoserine dehydrogenase
K1516_RS16155	COG0626	cystathionine gamma-synthase activity
K1516_RS16160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K1516_RS16165	COG0739	heme binding
K1516_RS16170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K1516_RS16175	COG1272	protein, Hemolysin III
K1516_RS16195	COG0463	Glycosyl transferase, family 2
K1516_RS16205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K1516_RS16215	COG4771	TonB-dependent receptor
K1516_RS16220	COG2226	methyltransferase
K1516_RS16250	COG1309	transcriptional regulator
K1516_RS16290	COG0583	DNA-binding transcription factor activity
K1516_RS16300	COG0509	glycine decarboxylation via glycine cleavage system
K1516_RS16305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K1516_RS16315	COG0330	HflC and HflK could
K1516_RS16325	COG1742	UPF0060 membrane protein
K1516_RS16330	COG3956	TIGRFAM MazG family protein
K1516_RS16335	COG1218	3'(2'),5'-bisphosphate nucleotidase
K1516_RS16340	COG0494	nUDIX hydrolase
K1516_RS16350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K1516_RS16365	COG0643	Histidine kinase
K1516_RS16365	COG0784	Response regulator, receiver
K1516_RS16365	COG2198	Histidine kinase
K1516_RS16370	COG0840	transmembrane signaling receptor activity
K1516_RS16375	COG0835	chemotaxis
K1516_RS16390	COG0189	ligase activity
K1516_RS16405	COG1199	ATP-dependent helicase activity
K1516_RS16415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K1516_RS16430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K1516_RS16440	COG1643	Atp-dependent helicase
K1516_RS16445	COG0783	Belongs to the Dps family
K1516_RS16450	COG0514	ATP-dependent DNA helicase (RecQ)
K1516_RS16460	COG2132	Multicopper oxidase
K1516_RS16555	COG2267	carboxylic ester hydrolase activity
K1516_RS16690	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K1516_RS16870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K1516_RS16875	COG0602	queuosine metabolic process
K1516_RS16885	COG2885	chlorophyll binding
K1516_RS16890	COG0823	Involved in the tonB-independent uptake of proteins
K1516_RS16905	COG0811	peptide transport
K1516_RS16910	COG0824	Thioesterase
K1516_RS16915	COG2255	four-way junction helicase activity
K1516_RS16925	COG0632	four-way junction helicase activity
K1516_RS16930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K1516_RS16935	COG0217	transcriptional regulatory protein
K1516_RS16955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K1516_RS16985	COG0488	(ABC) transporter
K1516_RS16995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K1516_RS16995	COG4651	solute:proton antiporter activity
K1516_RS17005	COG0745	RESPONSE REGULATOR receiver
K1516_RS17010	COG2205	protein histidine kinase activity
K1516_RS17020	COG0542	response to heat
K1516_RS17040	COG0028	Belongs to the TPP enzyme family
K1516_RS17065	COG3387	PFAM Glycoside hydrolase 15-related
K1516_RS17070	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
K1516_RS17075	COG3011	Protein conserved in bacteria
K1516_RS17090	COG0564	pseudouridine synthase activity
K1516_RS17095	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K1516_RS17105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K1516_RS17105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K1516_RS17135	COG1132	(ABC) transporter
K1516_RS17145	COG0045	succinate-CoA ligase (ADP-forming) activity
K1516_RS17175	COG4969	Belongs to the N-Me-Phe pilin family
K1516_RS17185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K1516_RS17255	COG2205	protein histidine kinase activity
K1516_RS17260	COG0745	RESPONSE REGULATOR receiver
K1516_RS17270	COG0189	ligase activity
K1516_RS17295	COG4625	pathogenesis
K1516_RS17295	COG3240	lipase activity
K1516_RS17305	COG2022	thiamine diphosphate biosynthetic process
K1516_RS17310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K1516_RS17315	COG0471	metal ion transport
K1516_RS17315	COG3273	potassium ion transport
K1516_RS17335	COG1970	mechanosensitive ion channel activity
K1516_RS17345	COG1115	amino acid carrier protein
K1516_RS17355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K1516_RS17360	COG1115	amino acid carrier protein
K1516_RS17365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1516_RS17370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS17375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS17400	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K1516_RS17410	COG3588	fructose-bisphosphate aldolase
K1516_RS17415	COG0469	pyruvate kinase activity
K1516_RS17425	COG0126	phosphoglycerate kinase activity
K1516_RS17440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K1516_RS17445	COG3047	cAMP biosynthetic process
K1516_RS17490	COG3093	addiction module antidote protein HigA
K1516_RS17500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K1516_RS17505	COG1301	dicarboxylic acid transport
K1516_RS17535	COG0714	Associated with various cellular activities
K1516_RS17565	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K1516_RS17580	COG5295	Hep Hag repeat protein
K1516_RS17620	COG0254	rRNA binding
K1516_RS17630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K1516_RS17640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K1516_RS17645	COG1758	RNA polymerase activity
K1516_RS17660	COG0437	4 iron, 4 sulfur cluster binding
K1516_RS17665	COG2864	formate dehydrogenase
K1516_RS17675	COG1921	L-seryl-tRNASec selenium transferase activity
K1516_RS17680	COG3276	selenocysteine insertion sequence binding
K1516_RS17690	COG0709	Synthesizes selenophosphate from selenide and ATP
K1516_RS17695	COG1561	YicC-like family, N-terminal region
K1516_RS17700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K1516_RS17705	COG0346	lactoylglutathione lyase activity
K1516_RS17715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K1516_RS17730	COG0006	proline dipeptidase activity
K1516_RS17735	COG0006	proline dipeptidase activity
K1516_RS17740	COG3079	Belongs to the UPF0149 family
K1516_RS17760	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K1516_RS17770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K1516_RS17780	COG2912	Transglutaminase-like superfamily
K1516_RS17785	COG1773	rubredoxin
K1516_RS17795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K1516_RS17810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K1516_RS17815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K1516_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS17855	COG0671	phosphoesterase, PA-phosphatase related
K1516_RS17865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K1516_RS17870	COG0563	adenylate kinase activity
K1516_RS17890	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K1516_RS17900	COG0848	biopolymer transport protein
K1516_RS17910	COG2832	Protein of unknown function (DUF454)
K1516_RS17945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K1516_RS17970	COG0745	RESPONSE REGULATOR receiver
K1516_RS17980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K1516_RS17985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K1516_RS17990	COG0405	Gamma-glutamyltransferase
K1516_RS17995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K1516_RS18010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K1516_RS18015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K1516_RS18020	COG2226	methyltransferase
K1516_RS18035	COG0473	3-isopropylmalate dehydrogenase activity
K1516_RS18050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS18055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS18065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K1516_RS18070	COG1538	Outer membrane efflux protein
K1516_RS18075	COG0531	amino acid
K1516_RS18080	COG1519	Transferase
K1516_RS18085	COG1560	Kdo2-lipid A biosynthetic process
K1516_RS18115	COG1301	dicarboxylic acid transport
K1516_RS18125	COG4191	Histidine kinase
K1516_RS18140	COG0642	Histidine kinase
K1516_RS18155	COG2851	Citrate transporter
K1516_RS18160	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS18185	COG1162	GTPase activity
K1516_RS18190	COG0436	Aminotransferase
K1516_RS18210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K1516_RS18225	COG1228	amidohydrolase
K1516_RS18230	COG0804	urea catabolic process
K1516_RS18240	COG1307	EDD domain protein, DegV family
K1516_RS18280	COG3706	GGDEF domain
K1516_RS18280	COG4251	negative regulation of phosphorylation
K1516_RS18280	COG2203	Gaf domain
K1516_RS18280	COG5001	Diguanylate cyclase
K1516_RS18285	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K1516_RS18295	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K1516_RS18305	COG4206	TonB-dependent receptor
K1516_RS18320	COG1902	pentaerythritol trinitrate reductase activity
K1516_RS18355	COG0583	DNA-binding transcription factor activity
K1516_RS18360	COG1064	alcohol dehydrogenase
K1516_RS18370	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K1516_RS18390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K1516_RS18395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K1516_RS18405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K1516_RS18410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K1516_RS18425	COG1522	sequence-specific DNA binding
K1516_RS18435	COG4773	Receptor
K1516_RS18470	COG0617	tRNA 3'-terminal CCA addition
K1516_RS18505	COG3468	outer membrane autotransporter barrel domain protein
K1516_RS18515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K1516_RS18520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K1516_RS18525	COG1609	Transcriptional regulator
K1516_RS18535	COG0837	glucose binding
K1516_RS18545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K1516_RS18565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K1516_RS18575	COG4191	Histidine kinase
K1516_RS18580	COG0784	Response regulator, receiver
K1516_RS18585	COG4251	negative regulation of phosphorylation
K1516_RS18590	COG2823	Periplasmic or secreted lipoprotein
K1516_RS18595	COG0673	inositol 2-dehydrogenase activity
K1516_RS18600	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K1516_RS18620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K1516_RS18625	COG0321	lipoyl(octanoyl) transferase activity
K1516_RS18630	COG2921	Belongs to the UPF0250 family
K1516_RS18640	COG1686	Belongs to the peptidase S11 family
K1516_RS18645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K1516_RS18650	COG2951	lytic endotransglycosylase activity
K1516_RS18655	COG0772	Belongs to the SEDS family
K1516_RS18660	COG0772	Belongs to the SEDS family
K1516_RS18675	COG1792	Involved in formation and maintenance of cell shape
K1516_RS18680	COG1077	Cell shape determining protein MreB Mrl
K1516_RS18685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K1516_RS18700	COG0308	aminopeptidase N
K1516_RS18705	COG2226	methyltransferase
K1516_RS18735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS18755	COG0673	inositol 2-dehydrogenase activity
K1516_RS18765	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K1516_RS18785	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K1516_RS18795	COG2832	Protein of unknown function (DUF454)
K1516_RS18805	COG0436	Aminotransferase
K1516_RS18810	COG1505	serine-type exopeptidase activity
K1516_RS18835	COG0697	spore germination
K1516_RS18840	COG1666	GTP binding
K1516_RS18870	COG0339	signal peptide processing
K1516_RS18880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K1516_RS18900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K1516_RS18910	COG1136	(ABC) transporter
K1516_RS18935	COG4191	Histidine kinase
K1516_RS18945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K1516_RS18960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K1516_RS18965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K1516_RS18970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K1516_RS18975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K1516_RS18980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K1516_RS18985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K1516_RS18995	COG0356	it plays a direct role in the translocation of protons across the membrane
K1516_RS19010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K1516_RS19015	COG0508	dehydrogenase complex catalyzes the overall conversion of
K1516_RS19035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K1516_RS19060	COG0181	hydroxymethylbilane synthase activity
K1516_RS19070	COG0745	RESPONSE REGULATOR receiver
K1516_RS19070	COG2972	Histidine kinase
K1516_RS19085	COG4771	TonB-dependent receptor
K1516_RS19100	COG0840	transmembrane signaling receptor activity
K1516_RS19145	COG0477	Major facilitator Superfamily
K1516_RS19175	COG0583	DNA-binding transcription factor activity
K1516_RS19180	COG0477	Major facilitator Superfamily
K1516_RS19215	COG0625	glutathione transferase activity
K1516_RS19230	COG2259	Doxx family
K1516_RS19290	COG0582	viral genome integration into host DNA
K1516_RS19385	COG0582	viral genome integration into host DNA
K1516_RS19400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K1516_RS19405	COG1490	D-aminoacyl-tRNA deacylase activity
K1516_RS19450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K1516_RS19450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K1516_RS19455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K1516_RS19460	COG0242	peptide deformylase activity
K1516_RS19470	COG0758	DNA mediated transformation
K1516_RS19475	COG2922	Belongs to the Smg family
K1516_RS19485	COG1714	RDD family
K1516_RS19490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K1516_RS19490	COG1754	DNA topoisomerase type I activity
K1516_RS19495	COG0009	L-threonylcarbamoyladenylate synthase
K1516_RS19510	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS19520	COG0616	signal peptide processing
K1516_RS19525	COG0534	Mate efflux family protein
K1516_RS19540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K1516_RS19545	COG0625	glutathione transferase activity
K1516_RS19555	COG1252	NADH dehydrogenase
K1516_RS19570	COG2860	membrane
K1516_RS19580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS19585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS19595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K1516_RS19615	COG1846	Transcriptional regulator
K1516_RS19640	COG0625	glutathione transferase activity
K1516_RS19650	COG0459	protein refolding
K1516_RS19655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K1516_RS19660	COG2356	endonuclease I
K1516_RS19665	COG1324	tolerance protein
K1516_RS19675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K1516_RS19685	COG0840	transmembrane signaling receptor activity
K1516_RS19705	COG4585	Histidine kinase
K1516_RS19725	COG0583	DNA-binding transcription factor activity
K1516_RS19735	COG1785	Belongs to the alkaline phosphatase family
K1516_RS19740	COG1686	Belongs to the peptidase S11 family
K1516_RS19750	COG2249	NAD(P)H dehydrogenase (quinone) activity
K1516_RS19770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K1516_RS19775	COG0511	ligase activity, forming carbon-carbon bonds
K1516_RS19780	COG0439	Biotin carboxylase
K1516_RS19795	COG2264	protein methyltransferase activity
K1516_RS19805	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K1516_RS19810	COG4589	Belongs to the CDS family
K1516_RS19815	COG0204	Acyl-transferase
K1516_RS19825	COG0671	phosphoesterase, PA-phosphatase related
K1516_RS19825	COG2453	phosphatase
K1516_RS19830	COG2267	carboxylic ester hydrolase activity
K1516_RS19835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K1516_RS19845	COG0138	bifunctional purine biosynthesis protein purh
K1516_RS19855	COG0151	Belongs to the GarS family
K1516_RS19870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K1516_RS19875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K1516_RS19880	COG2201	protein-glutamate methylesterase activity
K1516_RS19885	COG2177	Part of the ABC transporter FtsEX involved in
K1516_RS19890	COG2884	Cell division ATP-binding protein ftsE
K1516_RS19895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K1516_RS19905	COG3118	belongs to the thioredoxin family
K1516_RS19910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K1516_RS19915	COG3706	GGDEF domain
K1516_RS19925	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
K1516_RS19965	COG1652	LysM domain
K1516_RS19970	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K1516_RS19970	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K1516_RS19975	COG1473	amidohydrolase
K1516_RS19980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS19985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS19990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS20000	COG1289	transmembrane transporter activity
K1516_RS20005	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS20010	COG2814	Major facilitator Superfamily
K1516_RS20040	COG0316	Belongs to the HesB IscA family
K1516_RS20080	COG1051	belongs to the nudix hydrolase family
K1516_RS20095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K1516_RS20100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K1516_RS20105	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K1516_RS20115	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K1516_RS20120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K1516_RS20125	COG0730	response to heat
K1516_RS20135	COG0134	indole-3-glycerol-phosphate synthase activity
K1516_RS20140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K1516_RS20160	COG1597	lipid kinase activity
K1516_RS20175	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K1516_RS20180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K1516_RS20190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K1516_RS20190	COG2111	Na H antiporter
K1516_RS20195	COG1006	Multisubunit Na H antiporter MnhC subunit
K1516_RS20200	COG0651	ATP synthesis coupled electron transport
K1516_RS20205	COG1863	multisubunit Na H antiporter MnhE subunit
K1516_RS20210	COG2212	antiporter activity
K1516_RS20215	COG1320	monovalent cation:proton antiporter activity
K1516_RS20220	COG0530	calcium, potassium:sodium antiporter activity
K1516_RS20235	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K1516_RS20250	COG4804	nuclease activity
K1516_RS20265	COG3104	oligopeptide transport
K1516_RS20270	COG3483	tryptophan 2,3-dioxygenase activity
K1516_RS20300	COG2378	regulation of single-species biofilm formation
K1516_RS20315	COG2354	Protein conserved in bacteria
K1516_RS20320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K1516_RS20325	COG1368	sulfuric ester hydrolase activity
K1516_RS20330	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K1516_RS20330	COG3264	Mechanosensitive ion channel
K1516_RS20345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K1516_RS20380	COG1166	arginine decarboxylase activity
K1516_RS20385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K1516_RS20405	COG2960	long-chain fatty acid transporting porin activity
K1516_RS20475	COG0577	efflux transmembrane transporter activity
K1516_RS20585	COG0561	phosphatase activity
K1516_RS20590	COG3932	Exopolysaccharide synthesis, ExoD
K1516_RS20615	COG1999	signal sequence binding
K1516_RS20620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K1516_RS20625	COG1845	cytochrome c oxidase, subunit III
K1516_RS20635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K1516_RS20640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1516_RS20655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K1516_RS20660	COG1104	cysteine desulfurase activity
K1516_RS20685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K1516_RS20710	COG2031	fatty acid transporter
K1516_RS20730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K1516_RS20740	COG0673	inositol 2-dehydrogenase activity
K1516_RS20750	COG1501	Belongs to the glycosyl hydrolase 31 family
K1516_RS20755	COG2222	sugar isomerase
K1516_RS20760	COG1940	carbohydrate kinase activity
K1516_RS20770	COG1349	DNA-binding transcription factor activity
K1516_RS20775	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K1516_RS20780	COG2814	Major facilitator Superfamily
K1516_RS20795	COG1040	competence protein
K1516_RS20815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K1516_RS20820	COG0156	8-amino-7-oxononanoate synthase activity
K1516_RS20825	COG2267	carboxylic ester hydrolase activity
K1516_RS20830	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS20845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K1516_RS20865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K1516_RS20870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K1516_RS20875	COG2205	protein histidine kinase activity
K1516_RS20880	COG0745	RESPONSE REGULATOR receiver
K1516_RS20885	COG3541	Predicted nucleotidyltransferase
K1516_RS20890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K1516_RS20915	COG0714	Associated with various cellular activities
K1516_RS20925	COG0754	glutathionylspermidine amidase activity
K1516_RS20935	COG0129	dihydroxy-acid dehydratase activity
K1516_RS20940	COG2311	Membrane
K1516_RS20945	COG1199	ATP-dependent helicase activity
K1516_RS20955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K1516_RS20975	COG3781	membrane
K1516_RS21005	COG0625	glutathione transferase activity
K1516_RS21025	COG2207	Transcriptional regulator
K1516_RS21040	COG4555	ABC transporter
K1516_RS21070	COG0543	2 iron, 2 sulfur cluster binding
K1516_RS21070	COG0633	Ferredoxin
K1516_RS21075	COG1131	(ABC) transporter
K1516_RS21080	COG0842	Transport permease protein
K1516_RS21090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K1516_RS21100	COG0084	hydrolase, TatD family'
K1516_RS21105	COG1643	Atp-dependent helicase
K1516_RS21115	COG1187	pseudouridine synthase activity
K1516_RS21130	COG0667	Aldo Keto reductase
K1516_RS21145	COG1690	Belongs to the RtcB family
K1516_RS21160	COG0840	transmembrane signaling receptor activity
K1516_RS21165	COG0583	DNA-binding transcription factor activity
K1516_RS21170	COG2814	Major facilitator Superfamily
K1516_RS21175	COG0656	L-ascorbic acid biosynthetic process
K1516_RS21180	COG2267	carboxylic ester hydrolase activity
K1516_RS21185	COG0393	Putative heavy-metal-binding
K1516_RS21190	COG0045	succinate-CoA ligase (ADP-forming) activity
K1516_RS21190	COG1042	CoA-binding domain protein
K1516_RS21190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K1516_RS21195	COG2239	Acts as a magnesium transporter
K1516_RS21205	COG0666	response to abiotic stimulus
K1516_RS21205	COG3177	Filamentation induced by cAMP protein fic
K1516_RS21210	COG3100	YcgL domain-containing protein
K1516_RS21220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K1516_RS21225	COG1028	Short-chain dehydrogenase reductase Sdr
K1516_RS21245	COG0644	oxidoreductase
K1516_RS21265	COG2986	histidine ammonia-lyase
K1516_RS21275	COG0463	Glycosyl transferase, family 2
K1516_RS21290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1516_RS21295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K1516_RS21310	COG1294	oxidase, subunit
K1516_RS21315	COG1271	oxidase subunit
K1516_RS21325	COG3209	COG3209 Rhs family protein
K1516_RS21340	COG1595	DNA-templated transcription, initiation
K1516_RS21380	COG0408	coproporphyrinogen oxidase activity
K1516_RS21390	COG2323	membrane
K1516_RS21425	COG0515	serine threonine protein kinase
K1516_RS21425	COG2815	serine threonine protein kinase
K1516_RS21430	COG0631	protein serine/threonine phosphatase activity
K1516_RS21540	COG0589	response to stress
K1516_RS21560	COG0210	DNA helicase
K1516_RS21570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K1516_RS21575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K1516_RS21580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K1516_RS21595	COG0251	oxidation-reduction process
K1516_RS21635	COG0463	Glycosyl transferase, family 2
K1516_RS21650	COG1475	DNA binding
K1516_RS21655	COG1192	Involved in chromosome partitioning
K1516_RS21660	COG0357	Ribosomal RNA small subunit methyltransferase G
K1516_RS21665	COG2091	lysine biosynthetic process via aminoadipic acid
K1516_RS21705	COG1971	Probably functions as a manganese efflux pump
K1516_RS21710	COG0784	Response regulator, receiver
K1516_RS21710	COG2205	protein histidine kinase activity
K1516_RS21720	COG2911	Protein conserved in bacteria
K1516_RS21725	COG0729	surface antigen
K1516_RS21735	COG0752	glycyl-tRNA synthetase alpha subunit
K1516_RS21740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K1516_RS21745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K1516_RS21745	COG0519	Catalyzes the synthesis of GMP from XMP
K1516_RS21755	COG0805	protein transport
K1516_RS21765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K1516_RS21775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K1516_RS21785	COG0840	transmembrane signaling receptor activity
K1516_RS21840	COG3135	benzoate transporter
K1516_RS21855	COG2951	lytic endotransglycosylase activity
K1516_RS21860	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K1516_RS21865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K1516_RS21870	COG3706	GGDEF domain
K1516_RS21900	COG0302	gtp cyclohydrolase
K1516_RS21915	COG1566	PFAM secretion protein HlyD family protein
K1516_RS21925	COG1289	transmembrane transporter activity
K1516_RS21935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K1516_RS21940	COG1074	ATP-dependent DNA helicase activity
K1516_RS21945	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K1516_RS21950	COG1127	ABC transporter
K1516_RS21955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K1516_RS21960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K1516_RS21975	COG2853	Lipoprotein
K1516_RS21980	COG0386	Belongs to the glutathione peroxidase family
K1516_RS21990	COG1322	Protein conserved in bacteria
K1516_RS22005	COG0583	DNA-binding transcription factor activity
K1516_RS22025	COG0531	amino acid
K1516_RS22045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K1516_RS22050	COG0861	Integral membrane protein TerC family
K1516_RS22060	COG0584	glycerophosphoryl diester phosphodiesterase
K1516_RS22075	COG0706	membrane insertase activity
K1516_RS22080	COG0594	ribonuclease P activity
K1516_RS22085	COG0230	Belongs to the bacterial ribosomal protein bL34 family