locus-tag	class	description
LZ605_RS00005	COG0072	phenylalanine-tRNA ligase activity
LZ605_RS00005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZ605_RS00010	COG0776	regulation of translation
LZ605_RS00155	COG0305	Participates in initiation and elongation during chromosome replication
LZ605_RS00355	COG1794	racemase activity, acting on amino acids and derivatives
LZ605_RS00360	COG1280	lysine exporter protein (LysE YggA)
LZ605_RS00365	COG5487	UPF0391 membrane protein
LZ605_RS00370	COG2076	Multidrug Resistance protein
LZ605_RS00435	COG1162	GTPase activity
LZ605_RS00445	COG2197	response regulator
LZ605_RS00460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LZ605_RS00470	COG1960	acyl-CoA dehydrogenase activity
LZ605_RS00495	COG2130	NADP-dependent
LZ605_RS00500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LZ605_RS00500	COG2169	Transcriptional regulator
LZ605_RS00540	COG1309	transcriptional regulator
LZ605_RS00545	COG4771	TonB-dependent receptor
LZ605_RS00560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LZ605_RS00570	COG1570	exodeoxyribonuclease VII activity
LZ605_RS00575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LZ605_RS00580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LZ605_RS00580	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LZ605_RS00585	COG0802	atpase or kinase
LZ605_RS00590	COG0860	N-Acetylmuramoyl-L-alanine amidase
LZ605_RS00595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LZ605_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS00625	COG0501	Belongs to the peptidase M48B family
LZ605_RS00645	COG3300	MHYT domain
LZ605_RS00645	COG5001	Diguanylate cyclase
LZ605_RS00650	COG1509	lysine 2,3-aminomutase activity
LZ605_RS00655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LZ605_RS00660	COG0402	S-adenosylhomocysteine deaminase activity
LZ605_RS00665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LZ605_RS00685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LZ605_RS00705	COG2166	iron-sulfur cluster assembly
LZ605_RS00720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LZ605_RS00725	COG0137	argininosuccinate synthase activity
LZ605_RS00730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LZ605_RS00735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LZ605_RS00745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LZ605_RS00750	COG0165	Argininosuccinate lyase
LZ605_RS00765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LZ605_RS00775	COG1215	transferase activity, transferring glycosyl groups
LZ605_RS00780	COG0726	polysaccharide deacetylase
LZ605_RS00780	COG1649	PFAM Uncharacterised BCR, COG1649
LZ605_RS00830	COG1294	oxidase, subunit
LZ605_RS00840	COG4988	ABC transporter
LZ605_RS00845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LZ605_RS00855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZ605_RS00865	COG3088	subunit of a heme lyase
LZ605_RS00865	COG4235	cytochrome complex assembly
LZ605_RS00880	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LZ605_RS00900	COG4133	protoheme IX ABC transporter activity
LZ605_RS00905	COG0436	Aminotransferase
LZ605_RS00925	COG1187	pseudouridine synthase activity
LZ605_RS00930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LZ605_RS00935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LZ605_RS00940	COG2350	Protein conserved in bacteria
LZ605_RS00945	COG0271	Belongs to the BolA IbaG family
LZ605_RS00950	COG1609	Transcriptional regulator
LZ605_RS00975	COG0395	ABC-type sugar transport system, permease component
LZ605_RS00990	COG1530	ribonuclease E activity
LZ605_RS01000	COG0428	transporter
LZ605_RS01010	COG2154	pterin-4-alpha-carbinolamine dehydratase
LZ605_RS01015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LZ605_RS01015	COG0316	Belongs to the HesB IscA family
LZ605_RS01030	COG4290	ribonuclease
LZ605_RS01035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LZ605_RS01045	COG3104	oligopeptide transport
LZ605_RS01050	COG0705	Rhomboid family
LZ605_RS01070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LZ605_RS01075	COG0339	signal peptide processing
LZ605_RS01080	COG0386	Belongs to the glutathione peroxidase family
LZ605_RS01085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ605_RS01100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LZ605_RS01105	COG1595	DNA-templated transcription, initiation
LZ605_RS01125	COG1393	Belongs to the ArsC family
LZ605_RS01155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LZ605_RS01160	COG0084	hydrolase, TatD family'
LZ605_RS01180	COG0625	glutathione transferase activity
LZ605_RS01200	COG0305	Participates in initiation and elongation during chromosome replication
LZ605_RS01210	COG3540	Alkaline phosphatase
LZ605_RS01230	COG0583	DNA-binding transcription factor activity
LZ605_RS01250	COG0567	Dehydrogenase, E1 component
LZ605_RS01260	COG2850	peptidyl-arginine hydroxylation
LZ605_RS01275	COG0114	fumarate hydratase activity
LZ605_RS01305	COG1131	(ABC) transporter
LZ605_RS01310	COG1725	Transcriptional regulator
LZ605_RS01315	COG0386	Belongs to the glutathione peroxidase family
LZ605_RS01330	COG2900	Belongs to the SlyX family
LZ605_RS01340	COG2755	lipolytic protein G-D-S-L family
LZ605_RS01340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LZ605_RS01345	COG0646	methionine synthase
LZ605_RS01345	COG1410	methionine synthase
LZ605_RS01360	COG1960	acyl-CoA dehydrogenase activity
LZ605_RS01370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ605_RS01375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ605_RS01385	COG2902	Dehydrogenase
LZ605_RS01405	COG0667	Aldo Keto reductase
LZ605_RS01415	COG2925	Exonuclease
LZ605_RS01420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZ605_RS01425	COG3844	kynureninase activity
LZ605_RS01435	COG0288	reversible hydration of carbon dioxide
LZ605_RS01455	COG0017	Asparaginyl-tRNA synthetase
LZ605_RS01460	COG0316	Belongs to the HesB IscA family
LZ605_RS01470	COG0360	Binds together with S18 to 16S ribosomal RNA
LZ605_RS01475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LZ605_RS01480	COG0359	binds to the 23S rRNA
LZ605_RS01495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LZ605_RS01500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LZ605_RS01510	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LZ605_RS01520	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LZ605_RS01530	COG4993	Dehydrogenase
LZ605_RS01550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ605_RS01635	COG0583	DNA-binding transcription factor activity
LZ605_RS01640	COG2957	Belongs to the agmatine deiminase family
LZ605_RS01670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LZ605_RS01685	COG1228	amidohydrolase
LZ605_RS01720	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LZ605_RS01725	COG0077	Prephenate dehydratase
LZ605_RS01725	COG1605	Chorismate mutase
LZ605_RS01730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LZ605_RS01745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LZ605_RS01755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LZ605_RS01760	COG0583	DNA-binding transcription factor activity
LZ605_RS01910	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LZ605_RS01960	COG0210	DNA helicase
LZ605_RS02050	COG5001	Diguanylate cyclase
LZ605_RS02050	COG3300	MHYT domain
LZ605_RS02285	COG0666	response to abiotic stimulus
LZ605_RS02295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LZ605_RS02325	COG0210	DNA helicase
LZ605_RS02330	COG0604	alcohol dehydrogenase
LZ605_RS02335	COG1733	regulation of RNA biosynthetic process
LZ605_RS02355	COG4774	siderophore transport
LZ605_RS02390	COG2814	Major facilitator Superfamily
LZ605_RS02395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LZ605_RS02410	COG0456	acetyltransferase
LZ605_RS02415	COG2249	NAD(P)H dehydrogenase (quinone) activity
LZ605_RS02420	COG1733	regulation of RNA biosynthetic process
LZ605_RS02430	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LZ605_RS02440	COG1902	pentaerythritol trinitrate reductase activity
LZ605_RS02445	COG0668	transmembrane transport
LZ605_RS02455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LZ605_RS02475	COG0534	Mate efflux family protein
LZ605_RS02495	COG3243	poly(R)-hydroxyalkanoic acid synthase
LZ605_RS02520	COG2183	response to ionizing radiation
LZ605_RS02525	COG3447	MASE1 domain protein
LZ605_RS02525	COG5001	Diguanylate cyclase
LZ605_RS02525	COG5002	protein histidine kinase activity
LZ605_RS02530	COG0745	RESPONSE REGULATOR receiver
LZ605_RS02640	COG0789	Transcriptional regulator
LZ605_RS02650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ605_RS02665	COG0531	amino acid
LZ605_RS02690	COG1629	transport
LZ605_RS02690	COG4206	TonB-dependent receptor
LZ605_RS02710	COG3039	Transposase
LZ605_RS02720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LZ605_RS02720	COG0519	Catalyzes the synthesis of GMP from XMP
LZ605_RS02725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LZ605_RS02740	COG0587	DNA-directed DNA polymerase activity
LZ605_RS02795	COG2814	Major facilitator Superfamily
LZ605_RS02825	COG1285	pathogenesis
LZ605_RS02835	COG2186	Transcriptional regulator
LZ605_RS02840	COG1304	FMN binding
LZ605_RS02845	COG0277	FAD linked oxidase domain protein
LZ605_RS02960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LZ605_RS02965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LZ605_RS03000	COG2885	chlorophyll binding
LZ605_RS03085	COG3161	chorismate lyase activity
LZ605_RS03095	COG0583	DNA-binding transcription factor activity
LZ605_RS03105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LZ605_RS03110	COG3275	phosphorelay sensor kinase activity
LZ605_RS03115	COG2201	protein-glutamate methylesterase activity
LZ605_RS03130	COG2814	Major facilitator Superfamily
LZ605_RS03135	COG2197	response regulator
LZ605_RS03140	COG3850	Histidine kinase
LZ605_RS03155	COG1335	isochorismatase
LZ605_RS03175	COG2814	Major facilitator Superfamily
LZ605_RS03230	COG4964	Belongs to the GSP D family
LZ605_RS03275	COG2226	methyltransferase
LZ605_RS03290	COG0038	chloride channel
LZ605_RS03295	COG4772	TonB-dependent receptor
LZ605_RS03305	COG0583	DNA-binding transcription factor activity
LZ605_RS03340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LZ605_RS03345	COG4206	TonB-dependent receptor
LZ605_RS03350	COG3321	synthase
LZ605_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS03350	COG0604	alcohol dehydrogenase
LZ605_RS03355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LZ605_RS03360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LZ605_RS03375	COG1914	H( )-stimulated, divalent metal cation uptake system
LZ605_RS03390	COG4771	TonB-dependent receptor
LZ605_RS03430	COG0583	DNA-binding transcription factor activity
LZ605_RS03445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ605_RS03450	COG2409	Drug exporters of the RND superfamily
LZ605_RS03460	COG1169	isochorismate synthase
LZ605_RS03465	COG1021	2,3-dihydroxybenzoate-AMP ligase
LZ605_RS03470	COG1535	isochorismatase
LZ605_RS03470	COG3433	isochorismatase activity
LZ605_RS03480	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LZ605_RS03480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LZ605_RS03485	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS03530	COG2194	sulfuric ester hydrolase activity
LZ605_RS03540	COG2205	protein histidine kinase activity
LZ605_RS03565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LZ605_RS03570	COG0521	Mo-molybdopterin cofactor biosynthetic process
LZ605_RS03570	COG0315	cyclic pyranopterin monophosphate synthase activity
LZ605_RS03575	COG0303	'Molybdopterin
LZ605_RS03585	COG0314	molybdopterin synthase activity
LZ605_RS03590	COG0746	molybdenum cofactor guanylyltransferase activity
LZ605_RS03600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LZ605_RS03605	COG0725	ABC transporter, periplasmic molybdate-binding protein
LZ605_RS03610	COG4149	molybdate abc transporter
LZ605_RS03615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LZ605_RS03620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LZ605_RS03625	COG0840	transmembrane signaling receptor activity
LZ605_RS03715	COG4795	General secretion pathway protein
LZ605_RS03745	COG0811	peptide transport
LZ605_RS03805	COG2202	Pas domain
LZ605_RS03805	COG3920	Histidine kinase
LZ605_RS03835	COG3537	Alpha-1,2-mannosidase
LZ605_RS03840	COG0642	Histidine kinase
LZ605_RS03865	COG5002	protein histidine kinase activity
LZ605_RS03900	COG0656	L-ascorbic acid biosynthetic process
LZ605_RS03905	COG0583	DNA-binding transcription factor activity
LZ605_RS03920	COG1136	(ABC) transporter
LZ605_RS03945	COG0477	Major facilitator Superfamily
LZ605_RS03965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LZ605_RS03970	COG0243	molybdopterin cofactor binding
LZ605_RS04040	COG4566	intracellular signal transduction
LZ605_RS04045	COG4191	Histidine kinase
LZ605_RS04050	COG1285	pathogenesis
LZ605_RS04055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LZ605_RS04085	COG5002	protein histidine kinase activity
LZ605_RS04100	COG4774	siderophore transport
LZ605_RS04110	COG3214	Protein conserved in bacteria
LZ605_RS04115	COG5002	protein histidine kinase activity
LZ605_RS04115	COG5001	Diguanylate cyclase
LZ605_RS04115	COG3447	MASE1 domain protein
LZ605_RS04160	COG2084	Dehydrogenase
LZ605_RS04275	COG0583	DNA-binding transcription factor activity
LZ605_RS04285	COG0346	lactoylglutathione lyase activity
LZ605_RS04295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LZ605_RS04310	COG1404	Belongs to the peptidase S8 family
LZ605_RS04355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LZ605_RS04365	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LZ605_RS04380	COG1595	DNA-templated transcription, initiation
LZ605_RS04390	COG0702	epimerase
LZ605_RS04400	COG0784	Response regulator, receiver
LZ605_RS04405	COG4251	negative regulation of phosphorylation
LZ605_RS04410	COG4251	negative regulation of phosphorylation
LZ605_RS04425	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LZ605_RS04435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LZ605_RS04455	COG0318	PFAM AMP-dependent synthetase and ligase
LZ605_RS04490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ605_RS04510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LZ605_RS04525	COG0583	DNA-binding transcription factor activity
LZ605_RS04530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LZ605_RS04565	COG0745	RESPONSE REGULATOR receiver
LZ605_RS04645	COG3039	Transposase
LZ605_RS04690	COG1309	transcriptional regulator
LZ605_RS04705	COG1902	pentaerythritol trinitrate reductase activity
LZ605_RS04745	COG4644	lycopene metabolic process
LZ605_RS04800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LZ605_RS04930	COG0789	Transcriptional regulator
LZ605_RS04935	COG2608	mercury ion transmembrane transporter activity
LZ605_RS04940	COG2608	mercury ion transmembrane transporter activity
LZ605_RS04950	COG0789	Transcriptional regulator
LZ605_RS04970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LZ605_RS04975	COG4644	lycopene metabolic process
LZ605_RS05010	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LZ605_RS05045	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ605_RS05060	COG0010	Belongs to the arginase family
LZ605_RS05115	COG2132	Multicopper oxidase
LZ605_RS05145	COG4644	lycopene metabolic process
LZ605_RS05150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LZ605_RS05155	COG3039	Transposase
LZ605_RS05230	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LZ605_RS05235	COG1252	NADH dehydrogenase
LZ605_RS05265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LZ605_RS05270	COG1252	NADH dehydrogenase
LZ605_RS05290	COG0556	nucleotide-excision repair
LZ605_RS05295	COG3781	membrane
LZ605_RS05300	COG4191	Histidine kinase
LZ605_RS05305	COG2204	response regulator
LZ605_RS05310	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LZ605_RS05315	COG4149	molybdate abc transporter
LZ605_RS05320	COG0725	ABC transporter, periplasmic molybdate-binding protein
LZ605_RS05330	COG0746	molybdenum cofactor guanylyltransferase activity
LZ605_RS05335	COG0314	molybdopterin synthase activity
LZ605_RS05345	COG0303	'Molybdopterin
LZ605_RS05350	COG0521	Mo-molybdopterin cofactor biosynthetic process
LZ605_RS05350	COG0315	cyclic pyranopterin monophosphate synthase activity
LZ605_RS05355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LZ605_RS05360	COG0243	molybdopterin cofactor binding
LZ605_RS05365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LZ605_RS05370	COG1271	oxidase subunit
LZ605_RS05375	COG1294	oxidase, subunit
LZ605_RS05450	COG3209	COG3209 Rhs family protein
LZ605_RS05460	COG1858	cytochrome C peroxidase
LZ605_RS05475	COG0784	Response regulator, receiver
LZ605_RS05475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ605_RS05475	COG2198	Histidine kinase
LZ605_RS05475	COG2205	protein histidine kinase activity
LZ605_RS05490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LZ605_RS05505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LZ605_RS05510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ605_RS05515	COG4558	Periplasmic binding protein
LZ605_RS05525	COG2819	hydrolase of the alpha beta superfamily
LZ605_RS05540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LZ605_RS05555	COG1674	ftsk spoiiie
LZ605_RS05560	COG0492	ferredoxin-NADP+ reductase activity
LZ605_RS05585	COG0542	response to heat
LZ605_RS05595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LZ605_RS05610	COG0482	sulfurtransferase activity
LZ605_RS05615	COG2915	High frequency lysogenization protein hflD homolog
LZ605_RS05650	COG5002	protein histidine kinase activity
LZ605_RS05670	COG0835	chemotaxis
LZ605_RS05670	COG0784	Response regulator, receiver
LZ605_RS05675	COG1815	bacterial-type flagellum-dependent cell motility
LZ605_RS05695	COG4787	bacterial-type flagellum-dependent cell motility
LZ605_RS05705	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LZ605_RS05720	COG1256	bacterial-type flagellum assembly
LZ605_RS05745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LZ605_RS05765	COG2197	response regulator
LZ605_RS05790	COG1677	Flagellar hook-basal body complex protein FliE
LZ605_RS05840	COG3190	flagellar
LZ605_RS05850	COG1987	bacterial-type flagellum assembly
LZ605_RS05870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LZ605_RS05875	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LZ605_RS05900	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LZ605_RS05905	COG0643	Histidine kinase
LZ605_RS05905	COG0784	Response regulator, receiver
LZ605_RS05905	COG2198	Histidine kinase
LZ605_RS05910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LZ605_RS05915	COG1360	Flagellar Motor Protein
LZ605_RS05925	COG0835	chemotaxis
LZ605_RS05935	COG0745	RESPONSE REGULATOR receiver
LZ605_RS05945	COG0840	transmembrane signaling receptor activity
LZ605_RS05950	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LZ605_RS05955	COG0835	chemotaxis
LZ605_RS05965	COG0840	transmembrane signaling receptor activity
LZ605_RS05970	COG0840	transmembrane signaling receptor activity
LZ605_RS05980	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LZ605_RS06010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LZ605_RS06025	COG2828	Protein conserved in bacteria
LZ605_RS06030	COG0583	DNA-binding transcription factor activity
LZ605_RS06045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LZ605_RS06050	COG1309	transcriptional regulator
LZ605_RS06055	COG1012	belongs to the aldehyde dehydrogenase family
LZ605_RS06060	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LZ605_RS06065	COG0318	PFAM AMP-dependent synthetase and ligase
LZ605_RS06070	COG1024	Enoyl-CoA hydratase
LZ605_RS06080	COG0784	Response regulator, receiver
LZ605_RS06080	COG2198	Histidine kinase
LZ605_RS06080	COG2205	protein histidine kinase activity
LZ605_RS06090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LZ605_RS06100	COG1012	belongs to the aldehyde dehydrogenase family
LZ605_RS06115	COG0501	Belongs to the peptidase M48B family
LZ605_RS06120	COG3279	Response regulator of the LytR AlgR family
LZ605_RS06135	COG4676	Protein conserved in bacteria
LZ605_RS06155	COG3209	COG3209 Rhs family protein
LZ605_RS06155	COG3209	COG3209 Rhs family protein
LZ605_RS06175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LZ605_RS06185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LZ605_RS06190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LZ605_RS06195	COG0505	Belongs to the CarA family
LZ605_RS06200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LZ605_RS06215	COG2249	NAD(P)H dehydrogenase (quinone) activity
LZ605_RS06260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LZ605_RS06285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ605_RS06290	COG0745	RESPONSE REGULATOR receiver
LZ605_RS06295	COG5002	protein histidine kinase activity
LZ605_RS06310	COG0277	FAD linked oxidase domain protein
LZ605_RS06315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LZ605_RS06325	COG0531	amino acid
LZ605_RS06330	COG0531	amino acid
LZ605_RS06340	COG0235	Class ii aldolase
LZ605_RS06345	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LZ605_RS06350	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LZ605_RS06365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZ605_RS06375	COG1609	Transcriptional regulator
LZ605_RS06380	COG3537	Alpha-1,2-mannosidase
LZ605_RS06395	COG0789	Transcriptional regulator
LZ605_RS06405	COG4771	TonB-dependent receptor
LZ605_RS06410	COG3142	Participates in the control of copper homeostasis
LZ605_RS06415	COG1446	asparaginase
LZ605_RS06435	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LZ605_RS06435	COG0140	phosphoribosyl-ATP diphosphatase activity
LZ605_RS06440	COG0107	imidazoleglycerol-phosphate synthase activity
LZ605_RS06445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LZ605_RS06450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LZ605_RS06455	COG0131	Imidazoleglycerol-phosphate dehydratase
LZ605_RS06455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LZ605_RS06460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LZ605_RS06465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LZ605_RS06470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LZ605_RS06485	COG0124	histidyl-tRNA synthetase
LZ605_RS06490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LZ605_RS06505	COG0460	homoserine dehydrogenase
LZ605_RS06505	COG0527	aspartate kinase activity
LZ605_RS06545	COG0640	Transcriptional regulator
LZ605_RS06565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LZ605_RS06570	COG2205	protein histidine kinase activity
LZ605_RS06570	COG3437	response regulator, receiver
LZ605_RS06570	COG3850	Histidine kinase
LZ605_RS06570	COG4999	Histidine kinase
LZ605_RS06575	COG0784	Response regulator, receiver
LZ605_RS06575	COG4191	Histidine kinase
LZ605_RS06580	COG0745	RESPONSE REGULATOR receiver
LZ605_RS06630	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ605_RS06635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LZ605_RS06635	COG0517	IMP dehydrogenase activity
LZ605_RS06640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LZ605_RS06645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LZ605_RS06665	COG0438	transferase activity, transferring glycosyl groups
LZ605_RS06665	COG4641	Protein conserved in bacteria
LZ605_RS06675	COG0489	protein tyrosine kinase activity
LZ605_RS06675	COG3206	protein involved in exopolysaccharide biosynthesis
LZ605_RS06680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LZ605_RS06690	COG1012	belongs to the aldehyde dehydrogenase family
LZ605_RS06695	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS06710	COG0167	dihydroorotate dehydrogenase activity
LZ605_RS06715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LZ605_RS06720	COG0697	spore germination
LZ605_RS06735	COG1309	transcriptional regulator
LZ605_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS06775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ605_RS06780	COG1126	abc transporter atp-binding protein
LZ605_RS06795	COG1473	amidohydrolase
LZ605_RS06800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ605_RS06805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ605_RS06815	COG0431	NADPH-dependent FMN reductase
LZ605_RS06820	COG4206	TonB-dependent receptor
LZ605_RS06845	COG0640	Transcriptional regulator
LZ605_RS06860	COG0596	Alpha beta hydrolase
LZ605_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS06900	COG0583	DNA-binding transcription factor activity
LZ605_RS06915	COG0732	type I restriction modification DNA specificity domain
LZ605_RS06920	COG4804	nuclease activity
LZ605_RS06935	COG0519	Catalyzes the synthesis of GMP from XMP
LZ605_RS06935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LZ605_RS06955	COG0475	glutathione-regulated potassium exporter activity
LZ605_RS06955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LZ605_RS06960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LZ605_RS06965	COG1160	GTP binding
LZ605_RS06970	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ605_RS06975	COG2976	Protein conserved in bacteria
LZ605_RS06980	COG1426	Protein conserved in bacteria
LZ605_RS06980	COG1426	Protein conserved in bacteria
LZ605_RS06990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LZ605_RS06995	COG0105	UTP biosynthetic process
LZ605_RS07005	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZ605_RS07005	COG1024	Enoyl-CoA hydratase
LZ605_RS07010	COG0183	Belongs to the thiolase family
LZ605_RS07015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LZ605_RS07030	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LZ605_RS07040	COG0776	regulation of translation
LZ605_RS07050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LZ605_RS07055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LZ605_RS07065	COG2957	Belongs to the agmatine deiminase family
LZ605_RS07070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LZ605_RS07090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ605_RS07115	COG0488	(ABC) transporter
LZ605_RS07120	COG0583	DNA-binding transcription factor activity
LZ605_RS07130	COG0513	Belongs to the DEAD box helicase family
LZ605_RS07135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LZ605_RS07140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LZ605_RS07145	COG0625	glutathione transferase activity
LZ605_RS07150	COG1278	Cold shock
LZ605_RS07160	COG0564	pseudouridine synthase activity
LZ605_RS07165	COG4681	YaeQ
LZ605_RS07170	COG2081	HI0933 family
LZ605_RS07180	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LZ605_RS07185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LZ605_RS07195	COG1862	Preprotein translocase
LZ605_RS07200	COG0343	queuine tRNA-ribosyltransferase activity
LZ605_RS07205	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LZ605_RS07210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LZ605_RS07240	COG1132	(ABC) transporter
LZ605_RS07260	COG2223	nitrite transmembrane transporter activity
LZ605_RS07265	COG2207	Transcriptional regulator
LZ605_RS07270	COG0484	heat shock protein binding
LZ605_RS07275	COG0443	Heat shock 70 kDa protein
LZ605_RS07280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LZ605_RS07285	COG1420	regulation of RNA biosynthetic process
LZ605_RS07290	COG0497	DNA recombination
LZ605_RS07295	COG0583	DNA-binding transcription factor activity
LZ605_RS07305	COG0735	belongs to the Fur family
LZ605_RS07310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ605_RS07325	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LZ605_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS07420	COG0583	DNA-binding transcription factor activity
LZ605_RS07425	COG2885	chlorophyll binding
LZ605_RS07430	COG0415	Belongs to the DNA photolyase family
LZ605_RS07435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LZ605_RS07455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LZ605_RS07475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LZ605_RS07480	COG0405	Gamma-glutamyltransferase
LZ605_RS07485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LZ605_RS07495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LZ605_RS07500	COG0742	ribosomal rna small subunit methyltransferase
LZ605_RS07515	COG0552	protein localization to endoplasmic reticulum
LZ605_RS07525	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LZ605_RS07540	COG4591	ABC-type transport system involved in lipoprotein release permease component
LZ605_RS07560	COG1053	succinate dehydrogenase
LZ605_RS07565	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LZ605_RS07570	COG2009	succinate dehydrogenase
LZ605_RS07590	COG0837	glucose binding
LZ605_RS07595	COG0363	glucosamine-6-phosphate deaminase activity
LZ605_RS07600	COG0129	dihydroxy-acid dehydratase activity
LZ605_RS07605	COG0800	Aldolase
LZ605_RS07615	COG0671	phosphoesterase, PA-phosphatase related
LZ605_RS07620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LZ605_RS07630	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LZ605_RS07635	COG0166	Belongs to the GPI family
LZ605_RS07640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LZ605_RS07645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LZ605_RS07650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LZ605_RS07660	COG0617	tRNA 3'-terminal CCA addition
LZ605_RS07670	COG0477	Major facilitator Superfamily
LZ605_RS07675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LZ605_RS07685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LZ605_RS07695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LZ605_RS07700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LZ605_RS07715	COG0352	thiamine-phosphate diphosphorylase activity
LZ605_RS07715	COG0351	phosphomethylpyrimidine kinase
LZ605_RS07740	COG0583	DNA-binding transcription factor activity
LZ605_RS07745	COG1741	Belongs to the pirin family
LZ605_RS07755	COG2223	nitrite transmembrane transporter activity
LZ605_RS07770	COG3258	Cytochrome c
LZ605_RS07805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LZ605_RS07810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LZ605_RS07815	COG2137	regulation of response to DNA damage stimulus
LZ605_RS07820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LZ605_RS07825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LZ605_RS07830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LZ605_RS07835	COG1546	Belongs to the CinA family
LZ605_RS07840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LZ605_RS07845	COG1923	regulation of RNA biosynthetic process
LZ605_RS07850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LZ605_RS07855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LZ605_RS07865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LZ605_RS07870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LZ605_RS07875	COG1534	Rna-binding protein
LZ605_RS07900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LZ605_RS07905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LZ605_RS07910	COG2840	Smr protein MutS2
LZ605_RS07920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LZ605_RS07925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LZ605_RS07930	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LZ605_RS07935	COG0148	phosphopyruvate hydratase activity
LZ605_RS07950	COG0504	CTP synthase activity
LZ605_RS07965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LZ605_RS07985	COG1253	flavin adenine dinucleotide binding
LZ605_RS08000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ605_RS08005	COG1054	Belongs to the UPF0176 family
LZ605_RS08030	COG0069	glutamate synthase activity
LZ605_RS08035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LZ605_RS08195	COG5410	chromosome segregation
LZ605_RS08235	COG3179	chitinase
LZ605_RS08420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LZ605_RS08435	COG0348	domain, Protein
LZ605_RS08455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LZ605_RS08460	COG4977	sequence-specific DNA binding
LZ605_RS08460	COG1917	Cupin 2, conserved barrel domain protein
LZ605_RS08530	COG0577	efflux transmembrane transporter activity
LZ605_RS08530	COG1136	(ABC) transporter
LZ605_RS08560	COG0322	excinuclease ABC activity
LZ605_RS08570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LZ605_RS08575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LZ605_RS08580	COG1663	tetraacyldisaccharide 4'-kinase activity
LZ605_RS08595	COG0811	peptide transport
LZ605_RS08600	COG0658	competence protein
LZ605_RS08600	COG2333	competence protein COMEC
LZ605_RS08605	COG2205	protein histidine kinase activity
LZ605_RS08640	COG0556	nucleotide-excision repair
LZ605_RS08685	COG1611	Belongs to the LOG family
LZ605_RS08700	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LZ605_RS08710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LZ605_RS08745	COG2969	positive regulation of protein catabolic process
LZ605_RS08750	COG0625	glutathione transferase activity
LZ605_RS08755	COG2857	Cytochrome c1
LZ605_RS08760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LZ605_RS08765	COG0723	plastoquinol--plastocyanin reductase activity
LZ605_RS08770	COG0741	lytic transglycosylase activity
LZ605_RS08785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LZ605_RS08790	COG0842	Transport permease protein
LZ605_RS08795	COG1131	(ABC) transporter
LZ605_RS08840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LZ605_RS08850	COG1702	phosphate starvation-inducible protein PhoH
LZ605_RS08855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LZ605_RS08865	COG4535	Mg2 and Co2 transporter CorC
LZ605_RS08880	COG1012	belongs to the aldehyde dehydrogenase family
LZ605_RS08885	COG1177	transmembrane transport
LZ605_RS08890	COG1176	ABC-type spermidine putrescine transport system, permease component I
LZ605_RS08895	COG3842	ATPase activity
LZ605_RS08905	COG0174	glutamine synthetase
LZ605_RS08910	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LZ605_RS08915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LZ605_RS08940	COG2703	oxygen carrier activity
LZ605_RS08945	COG0477	Major facilitator Superfamily
LZ605_RS08950	COG1012	belongs to the aldehyde dehydrogenase family
LZ605_RS08955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LZ605_RS08965	COG2733	membrane
LZ605_RS08995	COG0116	Belongs to the methyltransferase superfamily
LZ605_RS08995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LZ605_RS09015	COG0494	nUDIX hydrolase
LZ605_RS09025	COG1024	Enoyl-CoA hydratase
LZ605_RS09035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LZ605_RS09045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LZ605_RS09050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LZ605_RS09055	COG0573	inorganic phosphate transmembrane transporter activity
LZ605_RS09060	COG0581	inorganic phosphate transmembrane transporter activity
LZ605_RS09070	COG0704	Plays a role in the regulation of phosphate uptake
LZ605_RS09080	COG3220	belongs to the UPF0276 family
LZ605_RS09090	COG2259	Doxx family
LZ605_RS09095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LZ605_RS09115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ605_RS09120	COG0577	efflux transmembrane transporter activity
LZ605_RS09120	COG1136	(ABC) transporter
LZ605_RS09125	COG1538	Outer membrane efflux protein
LZ605_RS09130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LZ605_RS09140	COG0557	exoribonuclease II activity
LZ605_RS09160	COG0583	DNA-binding transcription factor activity
LZ605_RS09170	COG2814	Major facilitator Superfamily
LZ605_RS09175	COG1566	PFAM secretion protein HlyD family protein
LZ605_RS09210	COG0475	glutathione-regulated potassium exporter activity
LZ605_RS09215	COG0367	asparagine synthase
LZ605_RS09225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LZ605_RS09230	COG1393	Belongs to the ArsC family
LZ605_RS09245	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LZ605_RS09265	COG3188	usher protein
LZ605_RS09285	COG0052	Belongs to the universal ribosomal protein uS2 family
LZ605_RS09290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LZ605_RS09300	COG0528	UMP kinase activity
LZ605_RS09305	COG0233	cytoplasmic translational termination
LZ605_RS09310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LZ605_RS09315	COG0575	Belongs to the CDS family
LZ605_RS09320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LZ605_RS09325	COG0750	zinc metalloprotease
LZ605_RS09330	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ605_RS09335	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZ605_RS09345	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZ605_RS09370	COG0825	malonyl-CoA metabolic process
LZ605_RS09375	COG1981	membrane
LZ605_RS09395	COG1695	Transcriptional regulator
LZ605_RS09445	COG1132	(ABC) transporter
LZ605_RS09450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ605_RS09470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LZ605_RS09480	COG1187	pseudouridine synthase activity
LZ605_RS09490	COG5001	Diguanylate cyclase
LZ605_RS09490	COG5002	protein histidine kinase activity
LZ605_RS09570	COG0735	belongs to the Fur family
LZ605_RS09575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LZ605_RS09590	COG4452	Inner membrane protein CreD
LZ605_RS09595	COG2205	protein histidine kinase activity
LZ605_RS09600	COG0745	RESPONSE REGULATOR receiver
LZ605_RS09605	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LZ605_RS09615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LZ605_RS09630	COG0588	phosphoglycerate mutase activity
LZ605_RS09650	COG3706	GGDEF domain
LZ605_RS09655	COG2814	Major facilitator Superfamily
LZ605_RS09675	COG0642	Histidine kinase
LZ605_RS09680	COG1647	Serine aminopeptidase, S33
LZ605_RS09705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LZ605_RS09730	COG0024	Methionine aminopeptidase
LZ605_RS09750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ605_RS09770	COG3134	Outer membrane lipoprotein
LZ605_RS09775	COG0840	transmembrane signaling receptor activity
LZ605_RS09790	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LZ605_RS09810	COG0534	Mate efflux family protein
LZ605_RS09830	COG0335	large ribosomal subunit rRNA binding
LZ605_RS09835	COG0336	Belongs to the RNA methyltransferase TrmD family
LZ605_RS09840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LZ605_RS09845	COG0228	four-way junction DNA binding
LZ605_RS09855	COG2070	2-Nitropropane dioxygenase
LZ605_RS09865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LZ605_RS09885	COG0326	Molecular chaperone. Has ATPase activity
LZ605_RS09900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LZ605_RS09905	COG1845	cytochrome c oxidase, subunit III
LZ605_RS09910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LZ605_RS09945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LZ605_RS09975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LZ605_RS09985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LZ605_RS09990	COG0196	riboflavin kinase activity
LZ605_RS09995	COG0728	peptidoglycan biosynthetic process
LZ605_RS10000	COG0268	Binds directly to 16S ribosomal RNA
LZ605_RS10005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LZ605_RS10010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LZ605_RS10015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LZ605_RS10020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LZ605_RS10025	COG0824	Thioesterase
LZ605_RS10045	COG1946	Acyl-CoA thioesterase
LZ605_RS10055	COG1595	DNA-templated transcription, initiation
LZ605_RS10065	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LZ605_RS10075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LZ605_RS10095	COG1073	alpha beta
LZ605_RS10125	COG4585	Histidine kinase
LZ605_RS10140	COG2894	cell division
LZ605_RS10145	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LZ605_RS10160	COG0823	Involved in the tonB-independent uptake of proteins
LZ605_RS10160	COG1506	peptidase
LZ605_RS10165	COG1297	OPT oligopeptide transporter protein
LZ605_RS10170	COG3104	oligopeptide transport
LZ605_RS10190	COG0456	acetyltransferase
LZ605_RS10190	COG0454	-acetyltransferase
LZ605_RS10195	COG0579	oxidoreductase
LZ605_RS10210	COG3052	prosthetic group binding
LZ605_RS10230	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LZ605_RS10245	COG1802	Transcriptional regulator
LZ605_RS10260	COG0477	Major facilitator Superfamily
LZ605_RS10270	COG1408	metallophosphoesterase
LZ605_RS10275	COG1253	flavin adenine dinucleotide binding
LZ605_RS10280	COG3655	Transcriptional regulator
LZ605_RS10315	COG0431	NADPH-dependent FMN reductase
LZ605_RS10325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LZ605_RS10330	COG0798	PFAM Bile acid sodium symporter
LZ605_RS10335	COG1609	Transcriptional regulator
LZ605_RS10345	COG2211	Major facilitator Superfamily
LZ605_RS10350	COG0673	inositol 2-dehydrogenase activity
LZ605_RS10360	COG2010	Cytochrome c
LZ605_RS10385	COG0629	single-stranded DNA binding
LZ605_RS10430	COG1131	(ABC) transporter
LZ605_RS10470	COG2190	(PTS) system
LZ605_RS10470	COG2211	Major facilitator Superfamily
LZ605_RS10480	COG1082	Xylose isomerase domain protein TIM barrel
LZ605_RS10500	COG0366	Alpha amylase catalytic
LZ605_RS10505	COG0142	geranyltranstransferase activity
LZ605_RS10525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LZ605_RS10535	COG0527	aspartate kinase activity
LZ605_RS10540	COG0384	phenazine biosynthesis protein PhzF
LZ605_RS10545	COG0384	phenazine biosynthesis protein PhzF
LZ605_RS10550	COG1764	response to oxidative stress
LZ605_RS10575	COG0693	protein deglycase activity
LZ605_RS10585	COG1959	2 iron, 2 sulfur cluster binding
LZ605_RS10590	COG0719	Fe-S assembly protein
LZ605_RS10595	COG0396	ATPase activity
LZ605_RS10600	COG0719	Fe-S assembly protein
LZ605_RS10605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LZ605_RS10615	COG2146	nitrite reductase [NAD(P)H] activity
LZ605_RS10625	COG4774	siderophore transport
LZ605_RS10635	COG3128	pkhd-type hydroxylase
LZ605_RS10645	COG4771	TonB-dependent receptor
LZ605_RS10665	COG1477	protein flavinylation
LZ605_RS10670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LZ605_RS10690	COG1555	photosystem II stabilization
LZ605_RS10700	COG2261	transglycosylase associated protein
LZ605_RS10710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LZ605_RS10720	COG0628	permease
LZ605_RS10730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LZ605_RS10750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LZ605_RS10770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LZ605_RS10785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LZ605_RS10800	COG1137	ATPase activity
LZ605_RS10810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LZ605_RS10815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LZ605_RS10820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LZ605_RS10825	COG1660	Displays ATPase and GTPase activities
LZ605_RS10840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LZ605_RS10845	COG2239	Acts as a magnesium transporter
LZ605_RS10865	COG0540	Belongs to the ATCase OTCase family
LZ605_RS10870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LZ605_RS10875	COG1678	Uncharacterized ACR, COG1678
LZ605_RS10885	COG2818	Glycosylase
LZ605_RS10905	COG0667	Aldo Keto reductase
LZ605_RS10925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LZ605_RS10935	COG0583	DNA-binding transcription factor activity
LZ605_RS10980	COG0583	DNA-binding transcription factor activity
LZ605_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS10990	COG0697	spore germination
LZ605_RS10995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZ605_RS11000	COG0583	DNA-binding transcription factor activity
LZ605_RS11025	COG2223	nitrite transmembrane transporter activity
LZ605_RS11035	COG4774	siderophore transport
LZ605_RS11075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LZ605_RS11080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LZ605_RS11085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LZ605_RS11090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LZ605_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS11105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LZ605_RS11115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LZ605_RS11120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LZ605_RS11125	COG1399	metal-binding, possibly nucleic acid-binding protein
LZ605_RS11140	COG0714	Associated with various cellular activities
LZ605_RS11160	COG0537	adenosine 5'-monophosphoramidase activity
LZ605_RS11170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LZ605_RS11175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LZ605_RS11200	COG2076	Multidrug Resistance protein
LZ605_RS11215	COG1234	tRNA 3'-trailer cleavage
LZ605_RS11220	COG3642	lipopolysaccharide core region biosynthetic process
LZ605_RS11225	COG0859	PFAM glycosyl transferase family 9
LZ605_RS11240	COG0631	protein serine/threonine phosphatase activity
LZ605_RS11245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LZ605_RS11250	COG0328	RNA-DNA hybrid ribonuclease activity
LZ605_RS11260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LZ605_RS11265	COG3942	CHAP domain
LZ605_RS11265	COG1388	LysM domain
LZ605_RS11270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LZ605_RS11310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LZ605_RS11315	COG0740	serine-type endopeptidase activity
LZ605_RS11320	COG0544	peptidyl-prolyl cis-trans isomerase activity
LZ605_RS11390	COG0473	3-isopropylmalate dehydrogenase activity
LZ605_RS11405	COG4783	chaperone-mediated protein folding
LZ605_RS11420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LZ605_RS11430	COG0248	Ppx GppA phosphatase
LZ605_RS11440	COG0438	transferase activity, transferring glycosyl groups
LZ605_RS11450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZ605_RS11455	COG3291	Pkd domain containing protein
LZ605_RS11465	COG2833	Protein of unknown function (DUF455)
LZ605_RS11485	COG0285	dihydrofolate synthase activity
LZ605_RS11490	COG0588	phosphoglycerate mutase activity
LZ605_RS11500	COG1063	alcohol dehydrogenase
LZ605_RS11520	COG1187	pseudouridine synthase activity
LZ605_RS11535	COG0604	alcohol dehydrogenase
LZ605_RS11540	COG2364	Membrane
LZ605_RS11545	COG0446	pyridine nucleotide-disulphide oxidoreductase
LZ605_RS11545	COG1902	pentaerythritol trinitrate reductase activity
LZ605_RS11555	COG0625	glutathione transferase activity
LZ605_RS11570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LZ605_RS11575	COG0564	pseudouridine synthase activity
LZ605_RS11580	COG0039	L-malate dehydrogenase activity
LZ605_RS11585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LZ605_RS11600	COG0154	amidase activity
LZ605_RS11610	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LZ605_RS11625	COG0203	ribosomal protein L17
LZ605_RS11630	COG0202	RNA polymerase activity
LZ605_RS11635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LZ605_RS11640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LZ605_RS11645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LZ605_RS11650	COG0201	protein transport
LZ605_RS11655	COG0200	Binds to the 23S rRNA
LZ605_RS11660	COG1841	ribosomal large subunit assembly
LZ605_RS11665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LZ605_RS11670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LZ605_RS11675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LZ605_RS11680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LZ605_RS11685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LZ605_RS11690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LZ605_RS11695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LZ605_RS11700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LZ605_RS11705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LZ605_RS11710	COG0255	Belongs to the universal ribosomal protein uL29 family
LZ605_RS11715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LZ605_RS11720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LZ605_RS11725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LZ605_RS11730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LZ605_RS11735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LZ605_RS11740	COG0089	rRNA binding
LZ605_RS11745	COG0088	Forms part of the polypeptide exit tunnel
LZ605_RS11750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LZ605_RS11755	COG0051	transcription antitermination factor activity, RNA binding
LZ605_RS11760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LZ605_RS11765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LZ605_RS11770	COG0049	tRNA binding
LZ605_RS11775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LZ605_RS11780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LZ605_RS11785	COG0085	RNA polymerase activity
LZ605_RS11790	COG0222	ribosome binding
LZ605_RS11795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LZ605_RS11800	COG0081	regulation of translation
LZ605_RS11805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LZ605_RS11810	COG0250	Participates in transcription elongation, termination and antitermination
LZ605_RS11825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LZ605_RS11860	COG0012	GTP binding
LZ605_RS11865	COG0193	aminoacyl-tRNA hydrolase activity
LZ605_RS11870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LZ605_RS11875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LZ605_RS11885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LZ605_RS11900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LZ605_RS11905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LZ605_RS11920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ605_RS11925	COG1295	ribonuclease BN
LZ605_RS11945	COG1404	Belongs to the peptidase S8 family
LZ605_RS11950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LZ605_RS11965	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LZ605_RS11990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LZ605_RS12005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LZ605_RS12005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LZ605_RS12040	COG2890	protein-(glutamine-N5) methyltransferase activity
LZ605_RS12050	COG3634	alkyl hydroperoxide reductase activity
LZ605_RS12055	COG0583	DNA-binding transcription factor activity
LZ605_RS12060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LZ605_RS12080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LZ605_RS12100	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LZ605_RS12105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LZ605_RS12110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZ605_RS12115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZ605_RS12125	COG2096	Adenosyltransferase
LZ605_RS12135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LZ605_RS12140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LZ605_RS12145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LZ605_RS12150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LZ605_RS12155	COG2967	ApaG domain
LZ605_RS12160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LZ605_RS12165	COG3738	Protein conserved in bacteria
LZ605_RS12175	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LZ605_RS12180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LZ605_RS12195	COG1704	LemA family
LZ605_RS12200	COG2814	Major facilitator Superfamily
LZ605_RS12205	COG0861	Integral membrane protein TerC family
LZ605_RS12210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LZ605_RS12220	COG0642	Histidine kinase
LZ605_RS12235	COG4181	ATPase activity
LZ605_RS12240	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LZ605_RS12255	COG4771	TonB-dependent receptor
LZ605_RS12265	COG0667	Aldo Keto reductase
LZ605_RS12270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LZ605_RS12275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZ605_RS12280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LZ605_RS12285	COG4106	trans-aconitate 2-methyltransferase activity
LZ605_RS12305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LZ605_RS12310	COG1607	acyl-coa hydrolase
LZ605_RS12315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LZ605_RS12325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LZ605_RS12330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LZ605_RS12350	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LZ605_RS12355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LZ605_RS12365	COG0494	nUDIX hydrolase
LZ605_RS12370	COG0653	protein targeting
LZ605_RS12375	COG0739	heme binding
LZ605_RS12385	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LZ605_RS12390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LZ605_RS12400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LZ605_RS12405	COG1181	Belongs to the D-alanine--D-alanine ligase family
LZ605_RS12410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LZ605_RS12430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LZ605_RS12445	COG3116	cell division
LZ605_RS12450	COG0275	rRNA processing
LZ605_RS12455	COG2001	Belongs to the MraZ family
LZ605_RS12490	COG1988	membrane-bound metal-dependent
LZ605_RS12495	COG0277	FAD linked oxidase domain protein
LZ605_RS12555	COG3121	Chaperone
LZ605_RS12570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LZ605_RS12575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LZ605_RS12610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LZ605_RS12610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LZ605_RS12615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LZ605_RS12630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LZ605_RS12640	COG0488	(ABC) transporter
LZ605_RS12645	COG2252	PERMEase
LZ605_RS12650	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LZ605_RS12655	COG0457	Tetratricopeptide repeat
LZ605_RS12655	COG3118	belongs to the thioredoxin family
LZ605_RS12665	COG1215	transferase activity, transferring glycosyl groups
LZ605_RS12680	COG2194	sulfuric ester hydrolase activity
LZ605_RS12710	COG3539	Fimbrial protein
LZ605_RS12735	COG1450	Type ii and iii secretion system protein
LZ605_RS12750	COG3166	PFAM Fimbrial assembly family protein
LZ605_RS12755	COG3156	type II secretion system protein K
LZ605_RS12760	COG4795	General secretion pathway protein
LZ605_RS12765	COG2165	general secretion pathway protein
LZ605_RS12770	COG4970	Tfp pilus assembly protein FimT
LZ605_RS12775	COG2165	general secretion pathway protein
LZ605_RS12780	COG1459	type II secretion system
LZ605_RS12785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LZ605_RS12790	COG1404	Belongs to the peptidase S8 family
LZ605_RS12795	COG5295	Hep Hag repeat protein
LZ605_RS12800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LZ605_RS12800	COG0047	phosphoribosylformylglycinamidine synthase activity
LZ605_RS12815	COG4974	Belongs to the 'phage' integrase family
LZ605_RS12825	COG0795	lipopolysaccharide-transporting ATPase activity
LZ605_RS12835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LZ605_RS12850	COG0525	valine-tRNA ligase activity
LZ605_RS12860	COG0456	acetyltransferase
LZ605_RS12870	COG1183	phosphatidylcholine synthase activity
LZ605_RS12880	COG0442	prolyl-tRNA aminoacylation
LZ605_RS12895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LZ605_RS12900	COG1127	ABC transporter
LZ605_RS12935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LZ605_RS12975	COG0463	Glycosyl transferase, family 2
LZ605_RS12985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZ605_RS12990	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS12995	COG0204	Acyl-transferase
LZ605_RS12995	COG0318	PFAM AMP-dependent synthetase and ligase
LZ605_RS13010	COG2076	Multidrug Resistance protein
LZ605_RS13015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LZ605_RS13065	COG0626	cystathionine gamma-synthase activity
LZ605_RS13100	COG1573	uracil-dna glycosylase
LZ605_RS13105	COG0625	glutathione transferase activity
LZ605_RS13115	COG0513	Belongs to the DEAD box helicase family
LZ605_RS13130	COG0720	synthase
LZ605_RS13140	COG0367	asparagine synthase
LZ605_RS13145	COG0745	RESPONSE REGULATOR receiver
LZ605_RS13150	COG2205	protein histidine kinase activity
LZ605_RS13155	COG5002	protein histidine kinase activity
LZ605_RS13160	COG0745	RESPONSE REGULATOR receiver
LZ605_RS13165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LZ605_RS13170	COG0785	Cytochrome C biogenesis protein
LZ605_RS13170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ605_RS13175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LZ605_RS13180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZ605_RS13185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LZ605_RS13190	COG1956	GAF domain-containing protein
LZ605_RS13215	COG0546	phosphoglycolate phosphatase activity
LZ605_RS13220	COG2226	methyltransferase
LZ605_RS13240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LZ605_RS13245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LZ605_RS13255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LZ605_RS13260	COG1187	pseudouridine synthase activity
LZ605_RS13265	COG2813	Specifically methylates the guanine in position
LZ605_RS13280	COG5002	protein histidine kinase activity
LZ605_RS13295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LZ605_RS13325	COG1360	Flagellar Motor Protein
LZ605_RS13350	COG0025	NhaP-type Na H and K H
LZ605_RS13355	COG3384	dioxygenase
LZ605_RS13365	COG0583	DNA-binding transcription factor activity
LZ605_RS13370	COG5001	Diguanylate cyclase
LZ605_RS13375	COG3590	peptidase
LZ605_RS13390	COG3279	Response regulator of the LytR AlgR family
LZ605_RS13395	COG3275	phosphorelay sensor kinase activity
LZ605_RS13405	COG4941	Belongs to the sigma-70 factor family
LZ605_RS13410	COG5507	3-demethylubiquinone-9 3-methyltransferase
LZ605_RS13420	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LZ605_RS13445	COG0741	lytic transglycosylase activity
LZ605_RS13450	COG1113	amino acid transport
LZ605_RS13455	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LZ605_RS13460	COG2814	Major facilitator Superfamily
LZ605_RS13470	COG0583	DNA-binding transcription factor activity
LZ605_RS13475	COG0488	(ABC) transporter
LZ605_RS13540	COG2267	carboxylic ester hydrolase activity
LZ605_RS13560	COG1401	restriction endodeoxyribonuclease activity
LZ605_RS13615	COG2375	cellular response to nickel ion
LZ605_RS13630	COG2353	YceI-like domain
LZ605_RS13635	COG0778	Nitroreductase
LZ605_RS13660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LZ605_RS13665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LZ605_RS13675	COG5383	Protein conserved in bacteria
LZ605_RS13725	COG4948	Mandelate Racemase Muconate Lactonizing
LZ605_RS13730	COG1737	Transcriptional regulator
LZ605_RS13740	COG0531	amino acid
LZ605_RS13750	COG4682	membrane
LZ605_RS13755	COG2133	pyrroloquinoline quinone binding
LZ605_RS13770	COG0668	transmembrane transport
LZ605_RS13775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LZ605_RS13785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LZ605_RS13805	COG1295	ribonuclease BN
LZ605_RS13810	COG0358	DNA primase activity
LZ605_RS13830	COG0109	protoheme IX farnesyltransferase activity
LZ605_RS13845	COG3346	SURF1 family
LZ605_RS13870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LZ605_RS13875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LZ605_RS13895	COG2067	long-chain fatty acid transport protein
LZ605_RS13905	COG0793	Belongs to the peptidase S41A family
LZ605_RS13910	COG4942	peptidase
LZ605_RS13920	COG2234	aminopeptidase activity
LZ605_RS13985	COG0739	heme binding
LZ605_RS14000	COG2211	Major facilitator Superfamily
LZ605_RS14005	COG0708	Exodeoxyribonuclease III
LZ605_RS14010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LZ605_RS14025	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LZ605_RS14030	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LZ605_RS14040	COG2205	protein histidine kinase activity
LZ605_RS14060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LZ605_RS14065	COG2197	response regulator
LZ605_RS14070	COG2003	Belongs to the UPF0758 family
LZ605_RS14075	COG0018	arginyl-trna synthetase
LZ605_RS14085	COG4221	oxidoreductase activity
LZ605_RS14090	COG4807	Protein conserved in bacteria
LZ605_RS14095	COG0583	DNA-binding transcription factor activity
LZ605_RS14100	COG2814	Major facilitator Superfamily
LZ605_RS14125	COG5507	3-demethylubiquinone-9 3-methyltransferase
LZ605_RS14140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LZ605_RS14160	COG0628	permease
LZ605_RS14175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LZ605_RS14190	COG2197	response regulator
LZ605_RS14195	COG4585	Histidine kinase
LZ605_RS14215	COG1136	(ABC) transporter
LZ605_RS14225	COG1136	(ABC) transporter
LZ605_RS14225	COG0577	efflux transmembrane transporter activity
LZ605_RS14235	COG0697	spore germination
LZ605_RS14240	COG0477	Major facilitator Superfamily
LZ605_RS14265	COG0180	Tryptophanyl-tRNA synthetase
LZ605_RS14275	COG3237	CsbD-like
LZ605_RS14320	COG3657	addiction module killer protein
LZ605_RS14350	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LZ605_RS14355	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LZ605_RS14355	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LZ605_RS14365	COG3228	Belongs to the MtfA family
LZ605_RS14385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LZ605_RS14400	COG0659	secondary active sulfate transmembrane transporter activity
LZ605_RS14420	COG1764	response to oxidative stress
LZ605_RS14430	COG1024	Enoyl-CoA hydratase
LZ605_RS14435	COG1024	Enoyl-CoA hydratase
LZ605_RS14440	COG1960	acyl-CoA dehydrogenase activity
LZ605_RS14450	COG1396	sequence-specific DNA binding
LZ605_RS14450	COG3800	Transcriptional regulator
LZ605_RS14460	COG1752	Esterase of the alpha-beta hydrolase superfamily
LZ605_RS14465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LZ605_RS14470	COG1335	isochorismatase
LZ605_RS14485	COG1902	pentaerythritol trinitrate reductase activity
LZ605_RS14495	COG1607	acyl-coa hydrolase
LZ605_RS14500	COG1280	lysine exporter protein (LysE YggA)
LZ605_RS14505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LZ605_RS14520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LZ605_RS14530	COG0697	spore germination
LZ605_RS14550	COG1960	acyl-CoA dehydrogenase activity
LZ605_RS14555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LZ605_RS14580	COG3706	GGDEF domain
LZ605_RS14585	COG2224	Isocitrate lyase
LZ605_RS14590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LZ605_RS14595	COG0583	DNA-binding transcription factor activity
LZ605_RS14600	COG0583	DNA-binding transcription factor activity
LZ605_RS14605	COG2814	Major facilitator Superfamily
LZ605_RS14610	COG0681	Belongs to the peptidase S26 family
LZ605_RS14625	COG0339	signal peptide processing
LZ605_RS14655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LZ605_RS14665	COG1181	Belongs to the D-alanine--D-alanine ligase family
LZ605_RS14675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZ605_RS14680	COG0318	PFAM AMP-dependent synthetase and ligase
LZ605_RS14690	COG0596	Alpha beta hydrolase
LZ605_RS14695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LZ605_RS14705	COG0612	Peptidase, M16
LZ605_RS14715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LZ605_RS14720	COG1960	acyl-CoA dehydrogenase activity
LZ605_RS14730	COG3474	cytochrome
LZ605_RS14735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ605_RS14735	COG2205	protein histidine kinase activity
LZ605_RS14740	COG2197	response regulator
LZ605_RS14775	COG2837	iron assimilation
LZ605_RS14875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LZ605_RS14880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LZ605_RS14915	COG0183	Belongs to the thiolase family
LZ605_RS14925	COG2032	superoxide dismutase activity
LZ605_RS14930	COG2032	superoxide dismutase activity
LZ605_RS14935	COG2204	response regulator
LZ605_RS14940	COG3852	Histidine kinase
LZ605_RS14950	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LZ605_RS14960	COG0004	ammonium transporteR
LZ605_RS14965	COG0347	Belongs to the P(II) protein family
LZ605_RS14970	COG0174	glutamine synthetase
LZ605_RS14975	COG1968	undecaprenyl-diphosphatase activity
LZ605_RS15010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LZ605_RS15030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LZ605_RS15050	COG0312	modulator of DNA gyrase
LZ605_RS15070	COG0714	Associated with various cellular activities
LZ605_RS15105	COG1205	dead DEAH box helicase
LZ605_RS15105	COG1111	helicase
LZ605_RS15130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ605_RS15135	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS15155	COG0067	glutamate synthase
LZ605_RS15155	COG0070	glutamate synthase
LZ605_RS15155	COG0069	glutamate synthase activity
LZ605_RS15160	COG0493	'glutamate synthase
LZ605_RS15165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ605_RS15165	COG2205	protein histidine kinase activity
LZ605_RS15170	COG1803	Methylglyoxal synthase
LZ605_RS15180	COG2974	May be involved in recombination
LZ605_RS15185	COG0037	tRNA processing
LZ605_RS15195	COG2937	Belongs to the GPAT DAPAT family
LZ605_RS15205	COG5640	endopeptidase activity
LZ605_RS15210	COG0284	orotidine-5'-phosphate decarboxylase activity
LZ605_RS15215	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LZ605_RS15220	COG3132	Protein of unknown function, DUF480
LZ605_RS15230	COG0210	DNA helicase
LZ605_RS15250	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LZ605_RS15255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LZ605_RS15270	COG1119	ATPase activity
LZ605_RS15290	COG4771	TonB-dependent receptor
LZ605_RS15300	COG1752	Esterase of the alpha-beta hydrolase superfamily
LZ605_RS15305	COG1522	sequence-specific DNA binding
LZ605_RS15310	COG3186	Phenylalanine-4-hydroxylase
LZ605_RS15325	COG0800	Aldolase
LZ605_RS15360	COG4772	TonB-dependent receptor
LZ605_RS15370	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LZ605_RS15440	COG0501	Belongs to the peptidase M48B family
LZ605_RS15445	COG1266	CAAX protease self-immunity
LZ605_RS15450	COG0187	DNA topoisomerase II activity
LZ605_RS15455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LZ605_RS15465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LZ605_RS15470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LZ605_RS15475	COG0594	ribonuclease P activity
LZ605_RS15480	COG0706	membrane insertase activity
LZ605_RS15495	COG0584	glycerophosphoryl diester phosphodiesterase
LZ605_RS15505	COG0861	Integral membrane protein TerC family
LZ605_RS15510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LZ605_RS15520	COG0531	amino acid
LZ605_RS15535	COG0583	DNA-binding transcription factor activity
LZ605_RS15550	COG1322	Protein conserved in bacteria
LZ605_RS15560	COG0386	Belongs to the glutathione peroxidase family
LZ605_RS15565	COG2853	Lipoprotein
LZ605_RS15580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LZ605_RS15585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LZ605_RS15590	COG1127	ABC transporter
LZ605_RS15595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LZ605_RS15600	COG1074	ATP-dependent DNA helicase activity
LZ605_RS15615	COG1289	transmembrane transporter activity
LZ605_RS15640	COG0302	gtp cyclohydrolase
LZ605_RS15670	COG3706	GGDEF domain
LZ605_RS15675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LZ605_RS15680	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LZ605_RS15685	COG2951	lytic endotransglycosylase activity
LZ605_RS15700	COG3135	benzoate transporter
LZ605_RS15755	COG0840	transmembrane signaling receptor activity
LZ605_RS15770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LZ605_RS15780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LZ605_RS15790	COG0805	protein transport
LZ605_RS15805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LZ605_RS15810	COG0752	glycyl-tRNA synthetase alpha subunit
LZ605_RS15820	COG0729	surface antigen
LZ605_RS15825	COG2911	Protein conserved in bacteria
LZ605_RS15835	COG0784	Response regulator, receiver
LZ605_RS15835	COG2205	protein histidine kinase activity
LZ605_RS15840	COG1971	Probably functions as a manganese efflux pump
LZ605_RS15845	COG1943	Transposase
LZ605_RS15890	COG0357	Ribosomal RNA small subunit methyltransferase G
LZ605_RS15895	COG1192	Involved in chromosome partitioning
LZ605_RS15900	COG1475	DNA binding
LZ605_RS15910	COG0463	Glycosyl transferase, family 2
LZ605_RS15945	COG0251	oxidation-reduction process
LZ605_RS15960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LZ605_RS15965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LZ605_RS15975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LZ605_RS15985	COG0210	DNA helicase
LZ605_RS16005	COG0589	response to stress
LZ605_RS16020	COG2323	membrane
LZ605_RS16030	COG0408	coproporphyrinogen oxidase activity
LZ605_RS16055	COG0494	nUDIX hydrolase
LZ605_RS16075	COG1595	DNA-templated transcription, initiation
LZ605_RS16085	COG1271	oxidase subunit
LZ605_RS16090	COG1294	oxidase, subunit
LZ605_RS16105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZ605_RS16110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZ605_RS16120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LZ605_RS16125	COG0463	Glycosyl transferase, family 2
LZ605_RS16135	COG2986	histidine ammonia-lyase
LZ605_RS16155	COG0644	oxidoreductase
LZ605_RS16175	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS16180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LZ605_RS16195	COG3100	YcgL domain-containing protein
LZ605_RS16210	COG2239	Acts as a magnesium transporter
LZ605_RS16215	COG0045	succinate-CoA ligase (ADP-forming) activity
LZ605_RS16215	COG1042	CoA-binding domain protein
LZ605_RS16215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LZ605_RS16220	COG0393	Putative heavy-metal-binding
LZ605_RS16225	COG2267	carboxylic ester hydrolase activity
LZ605_RS16230	COG0656	L-ascorbic acid biosynthetic process
LZ605_RS16235	COG2814	Major facilitator Superfamily
LZ605_RS16240	COG0583	DNA-binding transcription factor activity
LZ605_RS16245	COG0840	transmembrane signaling receptor activity
LZ605_RS16260	COG1690	Belongs to the RtcB family
LZ605_RS16275	COG0667	Aldo Keto reductase
LZ605_RS16285	COG1187	pseudouridine synthase activity
LZ605_RS16295	COG1643	Atp-dependent helicase
LZ605_RS16300	COG0084	hydrolase, TatD family'
LZ605_RS16310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LZ605_RS16315	COG0842	Transport permease protein
LZ605_RS16320	COG1131	(ABC) transporter
LZ605_RS16325	COG0543	2 iron, 2 sulfur cluster binding
LZ605_RS16325	COG0633	Ferredoxin
LZ605_RS16350	COG4555	ABC transporter
LZ605_RS16365	COG2207	Transcriptional regulator
LZ605_RS16385	COG0625	glutathione transferase activity
LZ605_RS16420	COG3781	membrane
LZ605_RS16440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LZ605_RS16450	COG1199	ATP-dependent helicase activity
LZ605_RS16455	COG2311	Membrane
LZ605_RS16485	COG0129	dihydroxy-acid dehydratase activity
LZ605_RS16495	COG0754	glutathionylspermidine amidase activity
LZ605_RS16505	COG0714	Associated with various cellular activities
LZ605_RS16530	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LZ605_RS16535	COG3541	Predicted nucleotidyltransferase
LZ605_RS16540	COG0745	RESPONSE REGULATOR receiver
LZ605_RS16545	COG2205	protein histidine kinase activity
LZ605_RS16550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ605_RS16555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ605_RS16575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LZ605_RS16590	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS16595	COG2267	carboxylic ester hydrolase activity
LZ605_RS16600	COG0156	8-amino-7-oxononanoate synthase activity
LZ605_RS16605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LZ605_RS16620	COG1040	competence protein
LZ605_RS16660	COG2814	Major facilitator Superfamily
LZ605_RS16665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LZ605_RS16670	COG1349	DNA-binding transcription factor activity
LZ605_RS16680	COG1940	carbohydrate kinase activity
LZ605_RS16685	COG2222	sugar isomerase
LZ605_RS16690	COG1501	Belongs to the glycosyl hydrolase 31 family
LZ605_RS16700	COG0673	inositol 2-dehydrogenase activity
LZ605_RS16720	COG2031	fatty acid transporter
LZ605_RS16770	COG1104	cysteine desulfurase activity
LZ605_RS16775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZ605_RS16790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LZ605_RS16795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LZ605_RS16805	COG1845	cytochrome c oxidase, subunit III
LZ605_RS16810	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LZ605_RS16815	COG1999	signal sequence binding
LZ605_RS16840	COG3932	Exopolysaccharide synthesis, ExoD
LZ605_RS16845	COG0561	phosphatase activity
LZ605_RS16880	COG0582	viral genome integration into host DNA
LZ605_RS17095	COG1196	nuclear chromosome segregation
LZ605_RS17115	COG2960	long-chain fatty acid transporting porin activity
LZ605_RS17135	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LZ605_RS17140	COG1166	arginine decarboxylase activity
LZ605_RS17160	COG3212	peptidase
LZ605_RS17175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LZ605_RS17190	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LZ605_RS17190	COG3264	Mechanosensitive ion channel
LZ605_RS17200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LZ605_RS17205	COG2354	Protein conserved in bacteria
LZ605_RS17220	COG2378	regulation of single-species biofilm formation
LZ605_RS17250	COG3483	tryptophan 2,3-dioxygenase activity
LZ605_RS17255	COG3104	oligopeptide transport
LZ605_RS17280	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LZ605_RS17295	COG0530	calcium, potassium:sodium antiporter activity
LZ605_RS17300	COG1320	monovalent cation:proton antiporter activity
LZ605_RS17305	COG2212	antiporter activity
LZ605_RS17310	COG1863	multisubunit Na H antiporter MnhE subunit
LZ605_RS17315	COG0651	ATP synthesis coupled electron transport
LZ605_RS17320	COG1006	Multisubunit Na H antiporter MnhC subunit
LZ605_RS17325	COG2111	Na H antiporter
LZ605_RS17325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LZ605_RS17335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LZ605_RS17340	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LZ605_RS17355	COG1597	lipid kinase activity
LZ605_RS17375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LZ605_RS17380	COG0134	indole-3-glycerol-phosphate synthase activity
LZ605_RS17390	COG0730	response to heat
LZ605_RS17395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LZ605_RS17400	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LZ605_RS17410	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LZ605_RS17415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LZ605_RS17420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LZ605_RS17435	COG1051	belongs to the nudix hydrolase family
LZ605_RS17475	COG0316	Belongs to the HesB IscA family
LZ605_RS17505	COG2814	Major facilitator Superfamily
LZ605_RS17510	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS17515	COG1289	transmembrane transporter activity
LZ605_RS17520	COG4771	TonB-dependent receptor
LZ605_RS17525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ605_RS17530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ605_RS17535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ605_RS17540	COG1473	amidohydrolase
LZ605_RS17545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LZ605_RS17545	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LZ605_RS17550	COG1652	LysM domain
LZ605_RS17590	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LZ605_RS17595	COG3706	GGDEF domain
LZ605_RS17615	COG1609	Transcriptional regulator
LZ605_RS17620	COG1472	Belongs to the glycosyl hydrolase 3 family
LZ605_RS17625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LZ605_RS17630	COG3118	belongs to the thioredoxin family
LZ605_RS17640	COG2884	Cell division ATP-binding protein ftsE
LZ605_RS17645	COG2177	Part of the ABC transporter FtsEX involved in
LZ605_RS17650	COG2201	protein-glutamate methylesterase activity
LZ605_RS17655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LZ605_RS17660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LZ605_RS17665	COG0151	Belongs to the GarS family
LZ605_RS17675	COG0138	bifunctional purine biosynthesis protein purh
LZ605_RS17680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LZ605_RS17685	COG2267	carboxylic ester hydrolase activity
LZ605_RS17690	COG0671	phosphoesterase, PA-phosphatase related
LZ605_RS17690	COG2453	phosphatase
LZ605_RS17705	COG4589	Belongs to the CDS family
LZ605_RS17710	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LZ605_RS17720	COG2264	protein methyltransferase activity
LZ605_RS17735	COG0439	Biotin carboxylase
LZ605_RS17740	COG0511	ligase activity, forming carbon-carbon bonds
LZ605_RS17745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LZ605_RS17755	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LZ605_RS17765	COG2249	NAD(P)H dehydrogenase (quinone) activity
LZ605_RS17775	COG1686	Belongs to the peptidase S11 family
LZ605_RS17780	COG1785	Belongs to the alkaline phosphatase family
LZ605_RS17790	COG0583	DNA-binding transcription factor activity
LZ605_RS17810	COG4585	Histidine kinase
LZ605_RS17815	COG2197	response regulator
LZ605_RS17830	COG0840	transmembrane signaling receptor activity
LZ605_RS17840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ605_RS17850	COG1324	tolerance protein
LZ605_RS17855	COG2356	endonuclease I
LZ605_RS17860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LZ605_RS17865	COG0459	protein refolding
LZ605_RS17875	COG1846	Transcriptional regulator
LZ605_RS17895	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LZ605_RS17905	COG2860	membrane
LZ605_RS17920	COG1252	NADH dehydrogenase
LZ605_RS17930	COG0625	glutathione transferase activity
LZ605_RS17935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LZ605_RS17950	COG0534	Mate efflux family protein
LZ605_RS17955	COG0616	signal peptide processing
LZ605_RS17965	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS17980	COG0009	L-threonylcarbamoyladenylate synthase
LZ605_RS17985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LZ605_RS17985	COG1754	DNA topoisomerase type I activity
LZ605_RS17990	COG1714	RDD family
LZ605_RS18000	COG2922	Belongs to the Smg family
LZ605_RS18005	COG0758	DNA mediated transformation
LZ605_RS18015	COG0242	peptide deformylase activity
LZ605_RS18020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LZ605_RS18025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LZ605_RS18025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LZ605_RS18070	COG1490	D-aminoacyl-tRNA deacylase activity
LZ605_RS18075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LZ605_RS18115	COG2259	Doxx family
LZ605_RS18120	COG0625	glutathione transferase activity
LZ605_RS18175	COG4771	TonB-dependent receptor
LZ605_RS18185	COG0400	carboxylic ester hydrolase activity
LZ605_RS18190	COG0745	RESPONSE REGULATOR receiver
LZ605_RS18190	COG2972	Histidine kinase
LZ605_RS18200	COG0181	hydroxymethylbilane synthase activity
LZ605_RS18225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LZ605_RS18245	COG0508	dehydrogenase complex catalyzes the overall conversion of
LZ605_RS18250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LZ605_RS18265	COG0356	it plays a direct role in the translocation of protons across the membrane
LZ605_RS18275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LZ605_RS18280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LZ605_RS18285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LZ605_RS18290	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LZ605_RS18295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LZ605_RS18300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LZ605_RS18310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LZ605_RS18325	COG2204	response regulator
LZ605_RS18335	COG0577	efflux transmembrane transporter activity
LZ605_RS18340	COG0577	efflux transmembrane transporter activity
LZ605_RS18340	COG1136	(ABC) transporter
LZ605_RS18345	COG1136	(ABC) transporter
LZ605_RS18355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LZ605_RS18385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LZ605_RS18395	COG0339	signal peptide processing
LZ605_RS18410	COG1666	GTP binding
LZ605_RS18425	COG0697	spore germination
LZ605_RS18430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LZ605_RS18450	COG1505	serine-type exopeptidase activity
LZ605_RS18455	COG0436	Aminotransferase
LZ605_RS18465	COG2832	Protein of unknown function (DUF454)
LZ605_RS18475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LZ605_RS18490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LZ605_RS18505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ605_RS18510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ605_RS18540	COG2226	methyltransferase
LZ605_RS18545	COG0308	aminopeptidase N
LZ605_RS18560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZ605_RS18565	COG1077	Cell shape determining protein MreB Mrl
LZ605_RS18570	COG1792	Involved in formation and maintenance of cell shape
LZ605_RS18585	COG0772	Belongs to the SEDS family
LZ605_RS18590	COG0772	Belongs to the SEDS family
LZ605_RS18595	COG2951	lytic endotransglycosylase activity
LZ605_RS18600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LZ605_RS18605	COG1686	Belongs to the peptidase S11 family
LZ605_RS18615	COG2921	Belongs to the UPF0250 family
LZ605_RS18625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LZ605_RS18645	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LZ605_RS18650	COG0673	inositol 2-dehydrogenase activity
LZ605_RS18655	COG2823	Periplasmic or secreted lipoprotein
LZ605_RS18660	COG4251	negative regulation of phosphorylation
LZ605_RS18665	COG0784	Response regulator, receiver
LZ605_RS18670	COG4191	Histidine kinase
LZ605_RS18680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LZ605_RS18700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LZ605_RS18710	COG0837	glucose binding
LZ605_RS18720	COG1609	Transcriptional regulator
LZ605_RS18725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LZ605_RS18730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LZ605_RS18740	COG3468	outer membrane autotransporter barrel domain protein
LZ605_RS18810	COG0617	tRNA 3'-terminal CCA addition
LZ605_RS18830	COG4773	Receptor
LZ605_RS18840	COG1522	sequence-specific DNA binding
LZ605_RS18855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LZ605_RS18860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LZ605_RS18870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LZ605_RS18875	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LZ605_RS18895	COG1064	alcohol dehydrogenase
LZ605_RS18900	COG0583	DNA-binding transcription factor activity
LZ605_RS18915	COG1902	pentaerythritol trinitrate reductase activity
LZ605_RS18930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LZ605_RS18940	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LZ605_RS18945	COG2203	Gaf domain
LZ605_RS18945	COG3706	GGDEF domain
LZ605_RS18945	COG4251	negative regulation of phosphorylation
LZ605_RS18945	COG5001	Diguanylate cyclase
LZ605_RS18985	COG1307	EDD domain protein, DegV family
LZ605_RS18995	COG0804	urea catabolic process
LZ605_RS19000	COG1228	amidohydrolase
LZ605_RS19015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LZ605_RS19035	COG0436	Aminotransferase
LZ605_RS19040	COG1162	GTPase activity
LZ605_RS19065	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS19070	COG2851	Citrate transporter
LZ605_RS19085	COG0642	Histidine kinase
LZ605_RS19100	COG4191	Histidine kinase
LZ605_RS19110	COG1301	dicarboxylic acid transport
LZ605_RS19140	COG1560	Kdo2-lipid A biosynthetic process
LZ605_RS19145	COG1519	Transferase
LZ605_RS19150	COG0531	amino acid
LZ605_RS19155	COG1538	Outer membrane efflux protein
LZ605_RS19170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ605_RS19175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ605_RS19190	COG0473	3-isopropylmalate dehydrogenase activity
LZ605_RS19205	COG2226	methyltransferase
LZ605_RS19210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LZ605_RS19230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LZ605_RS19240	COG0405	Gamma-glutamyltransferase
LZ605_RS19245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LZ605_RS19250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LZ605_RS19260	COG0745	RESPONSE REGULATOR receiver
LZ605_RS19280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LZ605_RS19320	COG2832	Protein of unknown function (DUF454)
LZ605_RS19330	COG0848	biopolymer transport protein
LZ605_RS19340	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LZ605_RS19360	COG0563	adenylate kinase activity
LZ605_RS19365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LZ605_RS19375	COG0671	phosphoesterase, PA-phosphatase related
LZ605_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
LZ605_RS19415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LZ605_RS19420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LZ605_RS19430	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LZ605_RS19435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LZ605_RS19440	COG0352	thiamine-phosphate diphosphorylase activity
LZ605_RS19445	COG1773	rubredoxin
LZ605_RS19450	COG2912	Transglutaminase-like superfamily
LZ605_RS19460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LZ605_RS19470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LZ605_RS19490	COG3079	Belongs to the UPF0149 family
LZ605_RS19495	COG0006	proline dipeptidase activity
LZ605_RS19500	COG0006	proline dipeptidase activity
LZ605_RS19515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LZ605_RS19525	COG0346	lactoylglutathione lyase activity
LZ605_RS19530	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LZ605_RS19535	COG1561	YicC-like family, N-terminal region
LZ605_RS19540	COG0709	Synthesizes selenophosphate from selenide and ATP
LZ605_RS19550	COG3276	selenocysteine insertion sequence binding
LZ605_RS19555	COG1921	L-seryl-tRNASec selenium transferase activity
LZ605_RS19565	COG2864	formate dehydrogenase
LZ605_RS19570	COG0437	4 iron, 4 sulfur cluster binding
LZ605_RS19585	COG1758	RNA polymerase activity
LZ605_RS19590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LZ605_RS19600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LZ605_RS19610	COG0254	rRNA binding
LZ605_RS19645	COG5295	Hep Hag repeat protein
LZ605_RS19660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LZ605_RS19690	COG0714	Associated with various cellular activities
LZ605_RS19710	COG2304	oxidoreductase activity
LZ605_RS19720	COG1301	dicarboxylic acid transport
LZ605_RS19725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LZ605_RS19770	COG3706	GGDEF domain
LZ605_RS19775	COG3047	cAMP biosynthetic process
LZ605_RS19780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LZ605_RS19795	COG0126	phosphoglycerate kinase activity
LZ605_RS19805	COG0469	pyruvate kinase activity
LZ605_RS19810	COG3588	fructose-bisphosphate aldolase
LZ605_RS19820	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LZ605_RS19845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ605_RS19850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ605_RS19855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LZ605_RS19860	COG1115	amino acid carrier protein
LZ605_RS19865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LZ605_RS19875	COG1970	mechanosensitive ion channel activity
LZ605_RS19895	COG0471	metal ion transport
LZ605_RS19895	COG3273	potassium ion transport
LZ605_RS19900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LZ605_RS19905	COG2022	thiamine diphosphate biosynthetic process
LZ605_RS19935	COG4974	Belongs to the 'phage' integrase family
LZ605_RS20105	COG1802	Transcriptional regulator
LZ605_RS20105	COG4626	Terminase
LZ605_RS20110	COG4695	Portal protein
LZ605_RS20115	COG0740	serine-type endopeptidase activity
LZ605_RS20220	COG3152	Membrane
LZ605_RS20240	COG0189	ligase activity
LZ605_RS20260	COG0745	RESPONSE REGULATOR receiver
LZ605_RS20280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LZ605_RS20320	COG0045	succinate-CoA ligase (ADP-forming) activity
LZ605_RS20330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LZ605_RS20330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LZ605_RS20340	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LZ605_RS20345	COG0564	pseudouridine synthase activity
LZ605_RS20360	COG3011	Protein conserved in bacteria
LZ605_RS20370	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LZ605_RS20375	COG3387	PFAM Glycoside hydrolase 15-related
LZ605_RS20400	COG0028	Belongs to the TPP enzyme family
LZ605_RS20420	COG0542	response to heat
LZ605_RS20430	COG2205	protein histidine kinase activity
LZ605_RS20435	COG0745	RESPONSE REGULATOR receiver
LZ605_RS20445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LZ605_RS20445	COG4651	solute:proton antiporter activity
LZ605_RS20455	COG0488	(ABC) transporter
LZ605_RS20470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LZ605_RS20485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LZ605_RS20505	COG0217	transcriptional regulatory protein
LZ605_RS20510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LZ605_RS20515	COG0632	four-way junction helicase activity
LZ605_RS20525	COG2255	four-way junction helicase activity
LZ605_RS20530	COG0824	Thioesterase
LZ605_RS20535	COG0811	peptide transport
LZ605_RS20550	COG0823	Involved in the tonB-independent uptake of proteins
LZ605_RS20555	COG2885	chlorophyll binding
LZ605_RS20565	COG0602	queuosine metabolic process
LZ605_RS20570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LZ605_RS20585	COG1733	regulation of RNA biosynthetic process
LZ605_RS20640	COG2132	Multicopper oxidase
LZ605_RS20650	COG0514	ATP-dependent DNA helicase (RecQ)
LZ605_RS20655	COG0783	Belongs to the Dps family
LZ605_RS20660	COG1643	Atp-dependent helicase
LZ605_RS20670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LZ605_RS20680	COG1216	Glycosyl transferase, family 2
LZ605_RS20685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LZ605_RS20695	COG1199	ATP-dependent helicase activity
LZ605_RS20700	COG1214	PFAM Peptidase M22, glycoprotease
LZ605_RS20710	COG0189	ligase activity
LZ605_RS20725	COG0835	chemotaxis
LZ605_RS20730	COG0840	transmembrane signaling receptor activity
LZ605_RS20735	COG0643	Histidine kinase
LZ605_RS20735	COG2198	Histidine kinase
LZ605_RS20735	COG0784	Response regulator, receiver
LZ605_RS20750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LZ605_RS20760	COG0494	nUDIX hydrolase
LZ605_RS20765	COG1218	3'(2'),5'-bisphosphate nucleotidase
LZ605_RS20770	COG3956	TIGRFAM MazG family protein
LZ605_RS20785	COG0330	HflC and HflK could
LZ605_RS20795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LZ605_RS20800	COG0509	glycine decarboxylation via glycine cleavage system
LZ605_RS20815	COG0583	DNA-binding transcription factor activity
LZ605_RS20860	COG1309	transcriptional regulator
LZ605_RS20865	COG4206	TonB-dependent receptor
LZ605_RS20875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LZ605_RS20885	COG0463	Glycosyl transferase, family 2
LZ605_RS20900	COG1272	protein, Hemolysin III
LZ605_RS20905	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LZ605_RS20910	COG0739	heme binding
LZ605_RS20915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZ605_RS20920	COG0626	cystathionine gamma-synthase activity
LZ605_RS20925	COG0527	aspartate kinase activity
LZ605_RS20925	COG0460	homoserine dehydrogenase
LZ605_RS20930	COG2267	carboxylic ester hydrolase activity
LZ605_RS20935	COG1760	l-serine dehydratase
LZ605_RS20950	COG3038	cytochrome b561
LZ605_RS20970	COG0477	Major facilitator Superfamily
LZ605_RS20990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LZ605_RS21005	COG0259	pyridoxamine-phosphate oxidase activity
LZ605_RS21040	COG3609	addiction module antidote protein, CC2985 family
LZ605_RS21045	COG2828	Protein conserved in bacteria
LZ605_RS21055	COG2373	Large extracellular alpha-helical protein
LZ605_RS21060	COG4953	penicillin-binding protein 1C
LZ605_RS21070	COG0678	peroxiredoxin activity
LZ605_RS21075	COG0484	heat shock protein binding
LZ605_RS21085	COG0604	alcohol dehydrogenase
LZ605_RS21090	COG0330	HflC and HflK could
LZ605_RS21095	COG0330	HflC and HflK could
LZ605_RS21105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LZ605_RS21115	COG0739	heme binding
LZ605_RS21120	COG1376	ErfK ybiS ycfS ynhG family protein
LZ605_RS21145	COG0753	catalase activity
LZ605_RS21150	COG2207	Transcriptional regulator
LZ605_RS21150	COG1917	Cupin 2, conserved barrel domain protein
LZ605_RS21155	COG1113	amino acid transport
LZ605_RS21165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LZ605_RS21165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LZ605_RS21170	COG2814	Major facilitator Superfamily
LZ605_RS21205	COG0745	RESPONSE REGULATOR receiver
LZ605_RS21210	COG2205	protein histidine kinase activity
LZ605_RS21230	COG2879	small protein
LZ605_RS21235	COG1966	Carbon starvation protein
LZ605_RS21240	COG1741	Belongs to the pirin family
LZ605_RS21250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LZ605_RS21255	COG1741	Belongs to the pirin family
LZ605_RS21275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LZ605_RS21280	COG0481	GTPase activity
LZ605_RS21285	COG0681	Belongs to the peptidase S26 family
LZ605_RS21300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LZ605_RS21305	COG1381	Involved in DNA repair and RecF pathway recombination
LZ605_RS21310	COG0745	RESPONSE REGULATOR receiver
LZ605_RS21315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LZ605_RS21320	COG2954	triphosphatase activity
LZ605_RS21325	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LZ605_RS21330	COG1472	Belongs to the glycosyl hydrolase 3 family
LZ605_RS21335	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LZ605_RS21340	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LZ605_RS21345	COG1278	Cold shock
LZ605_RS21350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LZ605_RS21365	COG1201	RNA secondary structure unwinding
LZ605_RS21370	COG1793	dna ligase
LZ605_RS21380	COG1960	acyl-CoA dehydrogenase activity
LZ605_RS21415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LZ605_RS21425	COG1451	nucleotide metabolic process
LZ605_RS21430	COG3122	Protein conserved in bacteria
LZ605_RS21435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LZ605_RS21475	COG0443	Heat shock 70 kDa protein
LZ605_RS21480	COG2824	Alkylphosphonate utilization operon protein PhnA
LZ605_RS21510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LZ605_RS21510	COG0392	lysyltransferase activity
LZ605_RS21515	COG0251	oxidation-reduction process
LZ605_RS21520	COG2878	Part of a membrane complex involved in electron transport
LZ605_RS21530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZ605_RS21530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZ605_RS21540	COG0346	lactoylglutathione lyase activity
LZ605_RS21555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LZ605_RS21580	COG4251	negative regulation of phosphorylation
LZ605_RS21580	COG5001	Diguanylate cyclase
LZ605_RS21580	COG2203	Gaf domain
LZ605_RS21580	COG3706	GGDEF domain
LZ605_RS21590	COG3118	belongs to the thioredoxin family
LZ605_RS21605	COG0495	leucyl-tRNA aminoacylation
LZ605_RS21620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LZ605_RS21630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LZ605_RS21640	COG0657	acetylesterase activity
LZ605_RS21640	COG2755	lipolytic protein G-D-S-L family
LZ605_RS21660	COG2968	Membrane
LZ605_RS21680	COG0312	modulator of DNA gyrase
LZ605_RS21685	COG3028	Belongs to the UPF0307 family
LZ605_RS21690	COG0312	modulator of DNA gyrase
LZ605_RS21700	COG0142	geranyltranstransferase activity
LZ605_RS21705	COG1722	exodeoxyribonuclease VII activity
LZ605_RS21725	COG1301	dicarboxylic acid transport
LZ605_RS21730	COG0791	NLP P60 protein
LZ605_RS21735	COG0791	NLP P60 protein
LZ605_RS21740	COG1047	Peptidyl-prolyl cis-trans
LZ605_RS21745	COG2311	Membrane
LZ605_RS21750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LZ605_RS21760	COG0697	spore germination
LZ605_RS21790	COG3590	peptidase
LZ605_RS21800	COG4206	TonB-dependent receptor
LZ605_RS21805	COG4771	TonB-dependent receptor
LZ605_RS21810	COG0489	protein tyrosine kinase activity
LZ605_RS21815	COG0717	Belongs to the dCTP deaminase family
LZ605_RS21830	COG0412	Dienelactone hydrolase
LZ605_RS21835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LZ605_RS21845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LZ605_RS21850	COG0433	COG0433 Predicted ATPase
LZ605_RS21865	COG0688	phosphatidylethanolamine metabolic process
LZ605_RS21870	COG1999	signal sequence binding
LZ605_RS21875	COG2890	protein-(glutamine-N5) methyltransferase activity
LZ605_RS21880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LZ605_RS21885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LZ605_RS21890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LZ605_RS21905	COG0101	tRNA pseudouridine synthase activity
LZ605_RS21910	COG0135	phosphoribosylanthranilate isomerase activity
LZ605_RS21945	COG0133	tryptophan synthase activity
LZ605_RS21955	COG0159	tryptophan synthase activity
LZ605_RS21960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LZ605_RS21965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LZ605_RS21975	COG0726	polysaccharide deacetylase
LZ605_RS21980	COG0438	transferase activity, transferring glycosyl groups
LZ605_RS21995	COG0149	triose-phosphate isomerase activity
LZ605_RS22010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ605_RS22015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ605_RS22020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ605_RS22025	COG0649	NAD binding
LZ605_RS22030	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LZ605_RS22045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LZ605_RS22050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LZ605_RS22060	COG0713	ATP synthesis coupled electron transport
LZ605_RS22075	COG1007	ATP synthesis coupled electron transport
LZ605_RS22090	COG0779	Required for maturation of 30S ribosomal subunits
LZ605_RS22095	COG0195	Participates in both transcription termination and antitermination
LZ605_RS22100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LZ605_RS22105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LZ605_RS22115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LZ605_RS22120	COG1185	polyribonucleotide nucleotidyltransferase activity
LZ605_RS22150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LZ605_RS22155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LZ605_RS22160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LZ605_RS22170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LZ605_RS22225	COG1162	GTPase activity
LZ605_RS22270	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
LZ605_RS22290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LZ605_RS22370	COG0730	response to heat
LZ605_RS22450	COG0305	Participates in initiation and elongation during chromosome replication
LZ605_RS22815	COG0305	Participates in initiation and elongation during chromosome replication