locus-tag	class	description
YH67_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
YH67_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YH67_RS00020	COG0187	DNA topoisomerase II activity
YH67_RS00030	COG0501	Belongs to the peptidase M48B family
YH67_RS00085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
YH67_RS00095	COG4772	TonB-dependent receptor
YH67_RS00130	COG0800	Aldolase
YH67_RS00135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YH67_RS00155	COG2272	Belongs to the type-B carboxylesterase lipase family
YH67_RS00170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YH67_RS00185	COG3507	Belongs to the glycosyl hydrolase 43 family
YH67_RS00190	COG1609	Transcriptional regulator
YH67_RS00200	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS00205	COG2755	lipolytic protein G-D-S-L family
YH67_RS00215	COG3186	Phenylalanine-4-hydroxylase
YH67_RS00220	COG1522	sequence-specific DNA binding
YH67_RS00230	COG1752	Esterase of the alpha-beta hydrolase superfamily
YH67_RS00245	COG0671	phosphoesterase, PA-phosphatase related
YH67_RS00260	COG1119	ATPase activity
YH67_RS00275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
YH67_RS00280	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
YH67_RS00290	COG1435	thymidine kinase activity
YH67_RS00305	COG3132	Protein of unknown function, DUF480
YH67_RS00310	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
YH67_RS00315	COG0284	orotidine-5'-phosphate decarboxylase activity
YH67_RS00325	COG2937	Belongs to the GPAT DAPAT family
YH67_RS00335	COG0037	tRNA processing
YH67_RS00340	COG2974	May be involved in recombination
YH67_RS00350	COG1803	Methylglyoxal synthase
YH67_RS00355	COG2205	protein histidine kinase activity
YH67_RS00355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YH67_RS00360	COG0493	'glutamate synthase
YH67_RS00365	COG0070	glutamate synthase
YH67_RS00365	COG0069	glutamate synthase activity
YH67_RS00365	COG0067	glutamate synthase
YH67_RS00385	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS00415	COG1111	helicase
YH67_RS00415	COG1205	dead DEAH box helicase
YH67_RS00455	COG0714	Associated with various cellular activities
YH67_RS00475	COG0312	modulator of DNA gyrase
YH67_RS00505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YH67_RS00525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YH67_RS00565	COG1968	undecaprenyl-diphosphatase activity
YH67_RS00570	COG0174	glutamine synthetase
YH67_RS00575	COG0347	Belongs to the P(II) protein family
YH67_RS00580	COG0004	ammonium transporteR
YH67_RS00585	COG3023	N-Acetylmuramoyl-L-alanine amidase
YH67_RS00590	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YH67_RS00605	COG3852	Histidine kinase
YH67_RS00610	COG2204	response regulator
YH67_RS00615	COG2032	superoxide dismutase activity
YH67_RS00620	COG2032	superoxide dismutase activity
YH67_RS00630	COG0183	Belongs to the thiolase family
YH67_RS00665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
YH67_RS00670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
YH67_RS00690	COG0798	PFAM Bile acid sodium symporter
YH67_RS00695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
YH67_RS00705	COG0431	NADPH-dependent FMN reductase
YH67_RS00740	COG2837	iron assimilation
YH67_RS00780	COG2197	response regulator
YH67_RS00785	COG2205	protein histidine kinase activity
YH67_RS00785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YH67_RS00790	COG3474	cytochrome
YH67_RS00800	COG1960	acyl-CoA dehydrogenase activity
YH67_RS00805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YH67_RS00815	COG0612	Peptidase, M16
YH67_RS00825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YH67_RS00830	COG0596	Alpha beta hydrolase
YH67_RS00840	COG0318	PFAM AMP-dependent synthetase and ligase
YH67_RS00845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YH67_RS00850	COG1181	Belongs to the D-alanine--D-alanine ligase family
YH67_RS00890	COG0339	signal peptide processing
YH67_RS00905	COG0681	Belongs to the peptidase S26 family
YH67_RS00910	COG2814	Major facilitator Superfamily
YH67_RS00915	COG0583	DNA-binding transcription factor activity
YH67_RS00920	COG0583	DNA-binding transcription factor activity
YH67_RS00925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YH67_RS00930	COG2224	Isocitrate lyase
YH67_RS00935	COG3706	GGDEF domain
YH67_RS00960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
YH67_RS00965	COG1960	acyl-CoA dehydrogenase activity
YH67_RS00985	COG0697	spore germination
YH67_RS00995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YH67_RS01010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YH67_RS01015	COG1280	lysine exporter protein (LysE YggA)
YH67_RS01020	COG1607	acyl-coa hydrolase
YH67_RS01030	COG1902	pentaerythritol trinitrate reductase activity
YH67_RS01045	COG1335	isochorismatase
YH67_RS01050	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YH67_RS01055	COG1752	Esterase of the alpha-beta hydrolase superfamily
YH67_RS01060	COG1396	sequence-specific DNA binding
YH67_RS01060	COG3800	Transcriptional regulator
YH67_RS01070	COG1960	acyl-CoA dehydrogenase activity
YH67_RS01075	COG1024	Enoyl-CoA hydratase
YH67_RS01080	COG1024	Enoyl-CoA hydratase
YH67_RS01090	COG1764	response to oxidative stress
YH67_RS01100	COG0659	secondary active sulfate transmembrane transporter activity
YH67_RS01110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YH67_RS01130	COG3228	Belongs to the MtfA family
YH67_RS01140	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
YH67_RS01140	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
YH67_RS01145	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
YH67_RS01160	COG3657	addiction module killer protein
YH67_RS01200	COG3237	CsbD-like
YH67_RS01210	COG0180	Tryptophanyl-tRNA synthetase
YH67_RS01235	COG0477	Major facilitator Superfamily
YH67_RS01240	COG0697	spore germination
YH67_RS01255	COG1136	(ABC) transporter
YH67_RS01255	COG0577	efflux transmembrane transporter activity
YH67_RS01265	COG1136	(ABC) transporter
YH67_RS01270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS01275	COG1131	(ABC) transporter
YH67_RS01285	COG4585	Histidine kinase
YH67_RS01290	COG2197	response regulator
YH67_RS01305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
YH67_RS01310	COG0546	phosphoglycolate phosphatase activity
YH67_RS01320	COG0628	permease
YH67_RS01340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YH67_RS01355	COG5507	3-demethylubiquinone-9 3-methyltransferase
YH67_RS01385	COG2814	Major facilitator Superfamily
YH67_RS01390	COG0583	DNA-binding transcription factor activity
YH67_RS01395	COG4807	Protein conserved in bacteria
YH67_RS01405	COG4221	oxidoreductase activity
YH67_RS01415	COG0018	arginyl-trna synthetase
YH67_RS01420	COG2003	Belongs to the UPF0758 family
YH67_RS01425	COG2197	response regulator
YH67_RS01430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YH67_RS01435	COG0756	dUTP diphosphatase activity
YH67_RS01450	COG2205	protein histidine kinase activity
YH67_RS01460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
YH67_RS01465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
YH67_RS01480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
YH67_RS01485	COG0708	Exodeoxyribonuclease III
YH67_RS01490	COG2223	nitrite transmembrane transporter activity
YH67_RS01505	COG0739	heme binding
YH67_RS01580	COG4942	peptidase
YH67_RS01585	COG0793	Belongs to the peptidase S41A family
YH67_RS01615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YH67_RS01645	COG3346	SURF1 family
YH67_RS01660	COG0109	protoheme IX farnesyltransferase activity
YH67_RS01675	COG0358	DNA primase activity
YH67_RS01680	COG1295	ribonuclease BN
YH67_RS01695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
YH67_RS01705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YH67_RS01710	COG0668	transmembrane transport
YH67_RS01725	COG2133	pyrroloquinoline quinone binding
YH67_RS01730	COG4682	membrane
YH67_RS01740	COG0531	amino acid
YH67_RS01750	COG1737	Transcriptional regulator
YH67_RS01755	COG4948	Mandelate Racemase Muconate Lactonizing
YH67_RS01805	COG5383	Protein conserved in bacteria
YH67_RS01815	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
YH67_RS01820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YH67_RS01850	COG0778	Nitroreductase
YH67_RS01855	COG2353	YceI-like domain
YH67_RS01865	COG2375	cellular response to nickel ion
YH67_RS01920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YH67_RS01940	COG2801	Transposase and inactivated derivatives
YH67_RS02005	COG2267	carboxylic ester hydrolase activity
YH67_RS02065	COG0488	(ABC) transporter
YH67_RS02070	COG0583	DNA-binding transcription factor activity
YH67_RS02080	COG2814	Major facilitator Superfamily
YH67_RS02085	COG4943	cyclic-guanylate-specific phosphodiesterase activity
YH67_RS02090	COG1113	amino acid transport
YH67_RS02095	COG0741	lytic transglycosylase activity
YH67_RS02120	COG2764	glyoxalase bleomycin resistance protein dioxygenase
YH67_RS02130	COG5507	3-demethylubiquinone-9 3-methyltransferase
YH67_RS02135	COG4941	Belongs to the sigma-70 factor family
YH67_RS02165	COG3275	phosphorelay sensor kinase activity
YH67_RS02170	COG3279	Response regulator of the LytR AlgR family
YH67_RS02190	COG3590	peptidase
YH67_RS02195	COG5001	Diguanylate cyclase
YH67_RS02200	COG0583	DNA-binding transcription factor activity
YH67_RS02210	COG3384	dioxygenase
YH67_RS02215	COG0025	NhaP-type Na H and K H
YH67_RS02240	COG1360	Flagellar Motor Protein
YH67_RS02270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YH67_RS02285	COG5002	protein histidine kinase activity
YH67_RS02300	COG2813	Specifically methylates the guanine in position
YH67_RS02305	COG1187	pseudouridine synthase activity
YH67_RS02310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YH67_RS02320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YH67_RS02325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
YH67_RS02340	COG0583	DNA-binding transcription factor activity
YH67_RS02345	COG2226	methyltransferase
YH67_RS02370	COG1956	GAF domain-containing protein
YH67_RS02375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YH67_RS02380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YH67_RS02385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YH67_RS02390	COG0785	Cytochrome C biogenesis protein
YH67_RS02390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YH67_RS02395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YH67_RS02400	COG0745	RESPONSE REGULATOR receiver
YH67_RS02405	COG5002	protein histidine kinase activity
YH67_RS02410	COG2205	protein histidine kinase activity
YH67_RS02415	COG0745	RESPONSE REGULATOR receiver
YH67_RS02420	COG0367	asparagine synthase
YH67_RS02430	COG0720	synthase
YH67_RS02445	COG0513	Belongs to the DEAD box helicase family
YH67_RS02455	COG0625	glutathione transferase activity
YH67_RS02460	COG1573	uracil-dna glycosylase
YH67_RS02495	COG0626	cystathionine gamma-synthase activity
YH67_RS02510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YH67_RS02525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YH67_RS02535	COG2076	Multidrug Resistance protein
YH67_RS02550	COG0318	PFAM AMP-dependent synthetase and ligase
YH67_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS02610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YH67_RS02615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YH67_RS02645	COG1127	ABC transporter
YH67_RS02650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YH67_RS02665	COG0442	prolyl-tRNA aminoacylation
YH67_RS02675	COG1183	phosphatidylcholine synthase activity
YH67_RS02685	COG0456	acetyltransferase
YH67_RS02695	COG0525	valine-tRNA ligase activity
YH67_RS02705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
YH67_RS02715	COG0795	lipopolysaccharide-transporting ATPase activity
YH67_RS02725	COG4974	Belongs to the 'phage' integrase family
YH67_RS02730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YH67_RS02740	COG0047	phosphoribosylformylglycinamidine synthase activity
YH67_RS02740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
YH67_RS02745	COG5295	Hep Hag repeat protein
YH67_RS02750	COG1404	Belongs to the peptidase S8 family
YH67_RS02755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YH67_RS02760	COG1459	type II secretion system
YH67_RS02765	COG2165	general secretion pathway protein
YH67_RS02770	COG4970	Tfp pilus assembly protein FimT
YH67_RS02775	COG2165	general secretion pathway protein
YH67_RS02780	COG4795	General secretion pathway protein
YH67_RS02785	COG3156	type II secretion system protein K
YH67_RS02790	COG3166	PFAM Fimbrial assembly family protein
YH67_RS02805	COG1450	Type ii and iii secretion system protein
YH67_RS02815	COG0463	Glycosyl transferase, family 2
YH67_RS02830	COG3539	Fimbrial protein
YH67_RS02850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YH67_RS02860	COG1215	transferase activity, transferring glycosyl groups
YH67_RS02875	COG2252	PERMEase
YH67_RS02880	COG0488	(ABC) transporter
YH67_RS02890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YH67_RS02905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
YH67_RS02910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YH67_RS02910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YH67_RS02935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
YH67_RS02940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YH67_RS02960	COG3468	outer membrane autotransporter barrel domain protein
YH67_RS02975	COG0277	FAD linked oxidase domain protein
YH67_RS02980	COG1988	membrane-bound metal-dependent
YH67_RS03010	COG2001	Belongs to the MraZ family
YH67_RS03015	COG0275	rRNA processing
YH67_RS03020	COG3116	cell division
YH67_RS03030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YH67_RS03035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YH67_RS03050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
YH67_RS03055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YH67_RS03060	COG1181	Belongs to the D-alanine--D-alanine ligase family
YH67_RS03065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YH67_RS03075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YH67_RS03080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
YH67_RS03090	COG0739	heme binding
YH67_RS03095	COG0653	protein targeting
YH67_RS03100	COG0494	nUDIX hydrolase
YH67_RS03110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
YH67_RS03115	COG2267	carboxylic ester hydrolase activity
YH67_RS03120	COG3275	phosphorelay sensor kinase activity
YH67_RS03130	COG0402	S-adenosylhomocysteine deaminase activity
YH67_RS03150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YH67_RS03155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
YH67_RS03165	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
YH67_RS03170	COG1607	acyl-coa hydrolase
YH67_RS03175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
YH67_RS03195	COG4106	trans-aconitate 2-methyltransferase activity
YH67_RS03200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YH67_RS03220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YH67_RS03225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YH67_RS03230	COG0667	Aldo Keto reductase
YH67_RS03240	COG4771	TonB-dependent receptor
YH67_RS03255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YH67_RS03260	COG4181	ATPase activity
YH67_RS03275	COG0642	Histidine kinase
YH67_RS03285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YH67_RS03290	COG0861	Integral membrane protein TerC family
YH67_RS03295	COG2814	Major facilitator Superfamily
YH67_RS03300	COG1704	LemA family
YH67_RS03315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
YH67_RS03320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
YH67_RS03335	COG3738	Protein conserved in bacteria
YH67_RS03340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
YH67_RS03345	COG2967	ApaG domain
YH67_RS03350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YH67_RS03355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
YH67_RS03360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YH67_RS03365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YH67_RS03375	COG2096	Adenosyltransferase
YH67_RS03385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YH67_RS03390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YH67_RS03395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YH67_RS03400	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
YH67_RS03420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YH67_RS03430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
YH67_RS03440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YH67_RS03445	COG0583	DNA-binding transcription factor activity
YH67_RS03450	COG3634	alkyl hydroperoxide reductase activity
YH67_RS03510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YH67_RS03535	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YH67_RS03550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YH67_RS03570	COG1404	Belongs to the peptidase S8 family
YH67_RS03590	COG1295	ribonuclease BN
YH67_RS03595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YH67_RS03610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
YH67_RS03615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
YH67_RS03630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
YH67_RS03640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YH67_RS03645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
YH67_RS03650	COG0193	aminoacyl-tRNA hydrolase activity
YH67_RS03655	COG0012	GTP binding
YH67_RS03670	COG4206	TonB-dependent receptor
YH67_RS03675	COG4242	Belongs to the peptidase S51 family
YH67_RS03700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YH67_RS03715	COG0250	Participates in transcription elongation, termination and antitermination
YH67_RS03720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
YH67_RS03725	COG0081	regulation of translation
YH67_RS03730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
YH67_RS03735	COG0222	ribosome binding
YH67_RS03740	COG0085	RNA polymerase activity
YH67_RS03745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YH67_RS03750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YH67_RS03755	COG0049	tRNA binding
YH67_RS03760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YH67_RS03765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YH67_RS03770	COG0051	transcription antitermination factor activity, RNA binding
YH67_RS03775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
YH67_RS03780	COG0088	Forms part of the polypeptide exit tunnel
YH67_RS03785	COG0089	rRNA binding
YH67_RS03790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
YH67_RS03795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YH67_RS03800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
YH67_RS03805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YH67_RS03810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YH67_RS03815	COG0255	Belongs to the universal ribosomal protein uL29 family
YH67_RS03820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YH67_RS03825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YH67_RS03830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
YH67_RS03835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
YH67_RS03840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
YH67_RS03845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YH67_RS03850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
YH67_RS03855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
YH67_RS03860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
YH67_RS03865	COG1841	ribosomal large subunit assembly
YH67_RS03870	COG0200	Binds to the 23S rRNA
YH67_RS03875	COG0201	protein transport
YH67_RS03880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
YH67_RS03885	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
YH67_RS03890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YH67_RS03895	COG0202	RNA polymerase activity
YH67_RS03900	COG0203	ribosomal protein L17
YH67_RS03915	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
YH67_RS03925	COG0154	amidase activity
YH67_RS03945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YH67_RS03950	COG0039	L-malate dehydrogenase activity
YH67_RS03955	COG0564	pseudouridine synthase activity
YH67_RS03960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YH67_RS03975	COG0625	glutathione transferase activity
YH67_RS03985	COG1902	pentaerythritol trinitrate reductase activity
YH67_RS03985	COG0446	pyridine nucleotide-disulphide oxidoreductase
YH67_RS03990	COG2364	Membrane
YH67_RS03995	COG0604	alcohol dehydrogenase
YH67_RS04010	COG1187	pseudouridine synthase activity
YH67_RS04030	COG1063	alcohol dehydrogenase
YH67_RS04040	COG0588	phosphoglycerate mutase activity
YH67_RS04045	COG0285	dihydrofolate synthase activity
YH67_RS04065	COG2833	Protein of unknown function (DUF455)
YH67_RS04075	COG3291	Pkd domain containing protein
YH67_RS04080	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YH67_RS04090	COG0438	transferase activity, transferring glycosyl groups
YH67_RS04100	COG4206	TonB-dependent receptor
YH67_RS04105	COG0248	Ppx GppA phosphatase
YH67_RS04110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YH67_RS04125	COG4783	chaperone-mediated protein folding
YH67_RS04140	COG0473	3-isopropylmalate dehydrogenase activity
YH67_RS04210	COG0544	peptidyl-prolyl cis-trans isomerase activity
YH67_RS04215	COG0740	serine-type endopeptidase activity
YH67_RS04220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
YH67_RS04260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YH67_RS04265	COG3942	CHAP domain
YH67_RS04265	COG1388	LysM domain
YH67_RS04270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YH67_RS04280	COG0328	RNA-DNA hybrid ribonuclease activity
YH67_RS04285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YH67_RS04290	COG0631	protein serine/threonine phosphatase activity
YH67_RS04305	COG0859	PFAM glycosyl transferase family 9
YH67_RS04310	COG3642	lipopolysaccharide core region biosynthetic process
YH67_RS04315	COG1234	tRNA 3'-trailer cleavage
YH67_RS04325	COG2076	Multidrug Resistance protein
YH67_RS04350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YH67_RS04355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
YH67_RS04365	COG0537	adenosine 5'-monophosphoramidase activity
YH67_RS04385	COG0714	Associated with various cellular activities
YH67_RS04400	COG1399	metal-binding, possibly nucleic acid-binding protein
YH67_RS04405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YH67_RS04410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YH67_RS04425	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS04435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YH67_RS04440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
YH67_RS04445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YH67_RS04450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YH67_RS04565	COG1388	LysM domain
YH67_RS04615	COG4774	siderophore transport
YH67_RS04625	COG2223	nitrite transmembrane transporter activity
YH67_RS04640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
YH67_RS04650	COG0583	DNA-binding transcription factor activity
YH67_RS04655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YH67_RS04660	COG0697	spore germination
YH67_RS04665	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS04670	COG0583	DNA-binding transcription factor activity
YH67_RS04680	COG2205	protein histidine kinase activity
YH67_RS04690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS04730	COG0583	DNA-binding transcription factor activity
YH67_RS04740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YH67_RS04755	COG0667	Aldo Keto reductase
YH67_RS04770	COG0456	acetyltransferase
YH67_RS04780	COG0519	Catalyzes the synthesis of GMP from XMP
YH67_RS04785	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
YH67_RS04790	COG1678	Uncharacterized ACR, COG1678
YH67_RS04795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
YH67_RS04800	COG0540	Belongs to the ATCase OTCase family
YH67_RS04820	COG2239	Acts as a magnesium transporter
YH67_RS04825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YH67_RS04840	COG1660	Displays ATPase and GTPase activities
YH67_RS04845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
YH67_RS04850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YH67_RS04855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YH67_RS04865	COG1137	ATPase activity
YH67_RS04880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YH67_RS04895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
YH67_RS04915	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YH67_RS04935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
YH67_RS04945	COG0628	permease
YH67_RS04955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
YH67_RS04965	COG2261	transglycosylase associated protein
YH67_RS04975	COG1555	photosystem II stabilization
YH67_RS04995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
YH67_RS05000	COG1477	protein flavinylation
YH67_RS05020	COG4771	TonB-dependent receptor
YH67_RS05030	COG3128	pkhd-type hydroxylase
YH67_RS05040	COG4774	siderophore transport
YH67_RS05050	COG2146	nitrite reductase [NAD(P)H] activity
YH67_RS05070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YH67_RS05075	COG0719	Fe-S assembly protein
YH67_RS05080	COG0396	ATPase activity
YH67_RS05085	COG0719	Fe-S assembly protein
YH67_RS05090	COG1959	2 iron, 2 sulfur cluster binding
YH67_RS05100	COG0693	protein deglycase activity
YH67_RS05125	COG1764	response to oxidative stress
YH67_RS05130	COG0384	phenazine biosynthesis protein PhzF
YH67_RS05135	COG0384	phenazine biosynthesis protein PhzF
YH67_RS05140	COG0527	aspartate kinase activity
YH67_RS05150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
YH67_RS05165	COG0142	geranyltranstransferase activity
YH67_RS05170	COG0366	Alpha amylase catalytic
YH67_RS05180	COG1082	Xylose isomerase domain protein TIM barrel
YH67_RS05190	COG2190	(PTS) system
YH67_RS05190	COG2211	Major facilitator Superfamily
YH67_RS05215	COG1131	(ABC) transporter
YH67_RS05225	COG0629	single-stranded DNA binding
YH67_RS05265	COG0583	DNA-binding transcription factor activity
YH67_RS05300	COG2010	Cytochrome c
YH67_RS05310	COG0673	inositol 2-dehydrogenase activity
YH67_RS05315	COG2211	Major facilitator Superfamily
YH67_RS05325	COG1609	Transcriptional regulator
YH67_RS05360	COG3655	Transcriptional regulator
YH67_RS05365	COG1253	flavin adenine dinucleotide binding
YH67_RS05370	COG1408	metallophosphoesterase
YH67_RS05375	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
YH67_RS05395	COG2259	Doxx family
YH67_RS05435	COG1802	Transcriptional regulator
YH67_RS05470	COG3052	prosthetic group binding
YH67_RS05485	COG0579	oxidoreductase
YH67_RS05510	COG3104	oligopeptide transport
YH67_RS05520	COG1297	OPT oligopeptide transporter protein
YH67_RS05525	COG1506	peptidase
YH67_RS05525	COG0823	Involved in the tonB-independent uptake of proteins
YH67_RS05540	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
YH67_RS05545	COG2894	cell division
YH67_RS05560	COG4585	Histidine kinase
YH67_RS05565	COG2197	response regulator
YH67_RS05600	COG0330	HflC and HflK could
YH67_RS05605	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
YH67_RS05615	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
YH67_RS05625	COG1595	DNA-templated transcription, initiation
YH67_RS05635	COG1946	Acyl-CoA thioesterase
YH67_RS05655	COG0824	Thioesterase
YH67_RS05660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YH67_RS05665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
YH67_RS05670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
YH67_RS05675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
YH67_RS05680	COG0268	Binds directly to 16S ribosomal RNA
YH67_RS05685	COG0728	peptidoglycan biosynthetic process
YH67_RS05690	COG0196	riboflavin kinase activity
YH67_RS05695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
YH67_RS05705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
YH67_RS05730	COG4206	TonB-dependent receptor
YH67_RS05750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YH67_RS05770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YH67_RS05775	COG1845	cytochrome c oxidase, subunit III
YH67_RS05780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YH67_RS05795	COG0326	Molecular chaperone. Has ATPase activity
YH67_RS05815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YH67_RS05830	COG0228	four-way junction DNA binding
YH67_RS05835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
YH67_RS05840	COG0336	Belongs to the RNA methyltransferase TrmD family
YH67_RS05845	COG0335	large ribosomal subunit rRNA binding
YH67_RS05865	COG0534	Mate efflux family protein
YH67_RS05890	COG0753	catalase activity
YH67_RS05995	COG2200	EAL domain
YH67_RS06000	COG2186	Transcriptional regulator
YH67_RS06025	COG0612	Peptidase, M16
YH67_RS06075	COG1475	DNA binding
YH67_RS06110	COG0840	transmembrane signaling receptor activity
YH67_RS06115	COG3134	Outer membrane lipoprotein
YH67_RS06130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS06155	COG0024	Methionine aminopeptidase
YH67_RS06180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YH67_RS06205	COG1647	Serine aminopeptidase, S33
YH67_RS06230	COG2814	Major facilitator Superfamily
YH67_RS06235	COG3706	GGDEF domain
YH67_RS06255	COG0588	phosphoglycerate mutase activity
YH67_RS06260	COG3590	peptidase
YH67_RS06270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YH67_RS06280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YH67_RS06285	COG0745	RESPONSE REGULATOR receiver
YH67_RS06290	COG2205	protein histidine kinase activity
YH67_RS06295	COG4452	Inner membrane protein CreD
YH67_RS06310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YH67_RS06315	COG0735	belongs to the Fur family
YH67_RS06395	COG5002	protein histidine kinase activity
YH67_RS06395	COG5001	Diguanylate cyclase
YH67_RS06405	COG1187	pseudouridine synthase activity
YH67_RS06415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
YH67_RS06435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YH67_RS06440	COG1132	(ABC) transporter
YH67_RS06490	COG1695	Transcriptional regulator
YH67_RS06510	COG1981	membrane
YH67_RS06515	COG0825	malonyl-CoA metabolic process
YH67_RS06540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YH67_RS06550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YH67_RS06560	COG0750	zinc metalloprotease
YH67_RS06565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
YH67_RS06570	COG0575	Belongs to the CDS family
YH67_RS06575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
YH67_RS06580	COG0233	cytoplasmic translational termination
YH67_RS06585	COG0528	UMP kinase activity
YH67_RS06595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
YH67_RS06600	COG0052	Belongs to the universal ribosomal protein uS2 family
YH67_RS06620	COG3188	usher protein
YH67_RS06640	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
YH67_RS06655	COG1393	Belongs to the ArsC family
YH67_RS06660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YH67_RS06670	COG0367	asparagine synthase
YH67_RS06675	COG0475	glutathione-regulated potassium exporter activity
YH67_RS06710	COG1566	PFAM secretion protein HlyD family protein
YH67_RS06715	COG2814	Major facilitator Superfamily
YH67_RS06730	COG0583	DNA-binding transcription factor activity
YH67_RS06750	COG0557	exoribonuclease II activity
YH67_RS06760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YH67_RS06765	COG1538	Outer membrane efflux protein
YH67_RS06770	COG0577	efflux transmembrane transporter activity
YH67_RS06770	COG1136	(ABC) transporter
YH67_RS06775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS06795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YH67_RS06800	COG2259	Doxx family
YH67_RS06810	COG3220	belongs to the UPF0276 family
YH67_RS06820	COG0704	Plays a role in the regulation of phosphate uptake
YH67_RS06830	COG0581	inorganic phosphate transmembrane transporter activity
YH67_RS06835	COG0573	inorganic phosphate transmembrane transporter activity
YH67_RS06840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YH67_RS06845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YH67_RS06855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YH67_RS06865	COG1024	Enoyl-CoA hydratase
YH67_RS06895	COG0116	Belongs to the methyltransferase superfamily
YH67_RS06895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YH67_RS06915	COG2733	membrane
YH67_RS06925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
YH67_RS06930	COG1012	belongs to the aldehyde dehydrogenase family
YH67_RS06940	COG0477	Major facilitator Superfamily
YH67_RS06945	COG2703	oxygen carrier activity
YH67_RS06970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YH67_RS06975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
YH67_RS06980	COG0174	glutamine synthetase
YH67_RS06990	COG2072	flavoprotein involved in K transport
YH67_RS06995	COG3842	ATPase activity
YH67_RS07000	COG1176	ABC-type spermidine putrescine transport system, permease component I
YH67_RS07005	COG1177	transmembrane transport
YH67_RS07010	COG1012	belongs to the aldehyde dehydrogenase family
YH67_RS07025	COG4535	Mg2 and Co2 transporter CorC
YH67_RS07045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
YH67_RS07050	COG1702	phosphate starvation-inducible protein PhoH
YH67_RS07055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS07060	COG1131	(ABC) transporter
YH67_RS07065	COG0842	Transport permease protein
YH67_RS07070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YH67_RS07085	COG0741	lytic transglycosylase activity
YH67_RS07090	COG0723	plastoquinol--plastocyanin reductase activity
YH67_RS07095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
YH67_RS07100	COG2857	Cytochrome c1
YH67_RS07105	COG0625	glutathione transferase activity
YH67_RS07110	COG2969	positive regulation of protein catabolic process
YH67_RS07145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YH67_RS07155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YH67_RS07170	COG1611	Belongs to the LOG family
YH67_RS07215	COG0556	nucleotide-excision repair
YH67_RS07250	COG3713	MltA-interacting MipA family protein
YH67_RS07270	COG0811	peptide transport
YH67_RS07275	COG0848	biopolymer transport protein
YH67_RS07285	COG1663	tetraacyldisaccharide 4'-kinase activity
YH67_RS07290	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
YH67_RS07295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
YH67_RS07305	COG0322	excinuclease ABC activity
YH67_RS07345	COG0577	efflux transmembrane transporter activity
YH67_RS07345	COG1136	(ABC) transporter
YH67_RS07395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YH67_RS07430	COG4977	sequence-specific DNA binding
YH67_RS07430	COG1917	Cupin 2, conserved barrel domain protein
YH67_RS07435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YH67_RS07455	COG0348	domain, Protein
YH67_RS07470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YH67_RS07485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
YH67_RS07490	COG0069	glutamate synthase activity
YH67_RS07515	COG1054	Belongs to the UPF0176 family
YH67_RS07520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YH67_RS07535	COG1253	flavin adenine dinucleotide binding
YH67_RS07545	COG0306	phosphate transporter
YH67_RS07555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YH67_RS07570	COG0504	CTP synthase activity
YH67_RS07575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
YH67_RS07590	COG0148	phosphopyruvate hydratase activity
YH67_RS07595	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
YH67_RS07600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
YH67_RS07605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
YH67_RS07615	COG2840	Smr protein MutS2
YH67_RS07620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
YH67_RS07625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
YH67_RS07645	COG1534	Rna-binding protein
YH67_RS07650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
YH67_RS07665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YH67_RS07670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
YH67_RS07675	COG1923	regulation of RNA biosynthetic process
YH67_RS07680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YH67_RS07685	COG1546	Belongs to the CinA family
YH67_RS07690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YH67_RS07695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
YH67_RS07700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
YH67_RS07705	COG2137	regulation of response to DNA damage stimulus
YH67_RS07710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YH67_RS07715	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YH67_RS07740	COG4773	Receptor
YH67_RS07755	COG1940	carbohydrate kinase activity
YH67_RS07795	COG3540	Alkaline phosphatase
YH67_RS07810	COG3258	Cytochrome c
YH67_RS07825	COG2223	nitrite transmembrane transporter activity
YH67_RS07840	COG1741	Belongs to the pirin family
YH67_RS07845	COG0583	DNA-binding transcription factor activity
YH67_RS07875	COG0351	phosphomethylpyrimidine kinase
YH67_RS07875	COG0352	thiamine-phosphate diphosphorylase activity
YH67_RS07890	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
YH67_RS07895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YH67_RS07905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YH67_RS07915	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
YH67_RS07920	COG0477	Major facilitator Superfamily
YH67_RS07930	COG0617	tRNA 3'-terminal CCA addition
YH67_RS07935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YH67_RS07940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
YH67_RS07945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
YH67_RS07955	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
YH67_RS07960	COG0166	Belongs to the GPI family
YH67_RS07975	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
YH67_RS07985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
YH67_RS07990	COG0671	phosphoesterase, PA-phosphatase related
YH67_RS08000	COG0800	Aldolase
YH67_RS08005	COG0129	dihydroxy-acid dehydratase activity
YH67_RS08015	COG0837	glucose binding
YH67_RS08020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YH67_RS08035	COG2009	succinate dehydrogenase
YH67_RS08040	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YH67_RS08045	COG1053	succinate dehydrogenase
YH67_RS08065	COG4591	ABC-type transport system involved in lipoprotein release permease component
YH67_RS08080	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
YH67_RS08090	COG0552	protein localization to endoplasmic reticulum
YH67_RS08105	COG0742	ribosomal rna small subunit methyltransferase
YH67_RS08110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
YH67_RS08120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YH67_RS08125	COG0405	Gamma-glutamyltransferase
YH67_RS08130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YH67_RS08150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
YH67_RS08170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YH67_RS08175	COG0415	Belongs to the DNA photolyase family
YH67_RS08180	COG2885	chlorophyll binding
YH67_RS08185	COG0583	DNA-binding transcription factor activity
YH67_RS08260	COG4977	sequence-specific DNA binding
YH67_RS08260	COG1917	Cupin 2, conserved barrel domain protein
YH67_RS08290	COG1404	Belongs to the peptidase S8 family
YH67_RS08320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
YH67_RS08330	COG2914	Belongs to the UPF0125 (RnfH) family
YH67_RS08335	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YH67_RS08340	COG0735	belongs to the Fur family
YH67_RS08350	COG0583	DNA-binding transcription factor activity
YH67_RS08355	COG0497	DNA recombination
YH67_RS08360	COG1420	regulation of RNA biosynthetic process
YH67_RS08365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
YH67_RS08370	COG0443	Heat shock 70 kDa protein
YH67_RS08375	COG0484	heat shock protein binding
YH67_RS08385	COG2207	Transcriptional regulator
YH67_RS08390	COG2223	nitrite transmembrane transporter activity
YH67_RS08400	COG1605	Chorismate mutase
YH67_RS08400	COG0287	Prephenate dehydrogenase
YH67_RS08410	COG1132	(ABC) transporter
YH67_RS08430	COG5001	Diguanylate cyclase
YH67_RS08430	COG4251	negative regulation of phosphorylation
YH67_RS08430	COG2203	Gaf domain
YH67_RS08430	COG3706	GGDEF domain
YH67_RS08440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YH67_RS08445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
YH67_RS08450	COG0343	queuine tRNA-ribosyltransferase activity
YH67_RS08455	COG1862	Preprotein translocase
YH67_RS08465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YH67_RS08470	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
YH67_RS08480	COG2081	HI0933 family
YH67_RS08485	COG4681	YaeQ
YH67_RS08505	COG0625	glutathione transferase activity
YH67_RS08510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
YH67_RS08515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
YH67_RS08520	COG0513	Belongs to the DEAD box helicase family
YH67_RS08530	COG0583	DNA-binding transcription factor activity
YH67_RS08535	COG0488	(ABC) transporter
YH67_RS08560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YH67_RS08575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YH67_RS08580	COG2957	Belongs to the agmatine deiminase family
YH67_RS08590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YH67_RS08595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
YH67_RS08605	COG0776	regulation of translation
YH67_RS08615	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
YH67_RS08630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YH67_RS08635	COG0183	Belongs to the thiolase family
YH67_RS08640	COG1250	3-hydroxyacyl-CoA dehydrogenase
YH67_RS08640	COG1024	Enoyl-CoA hydratase
YH67_RS08650	COG0105	UTP biosynthetic process
YH67_RS08655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
YH67_RS08665	COG1426	Protein conserved in bacteria
YH67_RS08670	COG2976	Protein conserved in bacteria
YH67_RS08675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YH67_RS08680	COG1160	GTP binding
YH67_RS08690	COG0583	DNA-binding transcription factor activity
YH67_RS08695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YH67_RS08700	COG0475	glutathione-regulated potassium exporter activity
YH67_RS08700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YH67_RS08720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
YH67_RS08720	COG0519	Catalyzes the synthesis of GMP from XMP
YH67_RS08735	COG0583	DNA-binding transcription factor activity
YH67_RS08760	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS08775	COG0596	Alpha beta hydrolase
YH67_RS08790	COG0640	Transcriptional regulator
YH67_RS08805	COG4716	Myosin-crossreactive antigen
YH67_RS08830	COG0431	NADPH-dependent FMN reductase
YH67_RS08840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YH67_RS08845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YH67_RS08850	COG1473	amidohydrolase
YH67_RS08860	COG0765	amino acid transport
YH67_RS08865	COG1126	abc transporter atp-binding protein
YH67_RS08870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YH67_RS08890	COG4943	cyclic-guanylate-specific phosphodiesterase activity
YH67_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS08915	COG1309	transcriptional regulator
YH67_RS08930	COG0697	spore germination
YH67_RS08935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YH67_RS08940	COG0167	dihydroorotate dehydrogenase activity
YH67_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS08960	COG1012	belongs to the aldehyde dehydrogenase family
YH67_RS08975	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YH67_RS09040	COG0745	RESPONSE REGULATOR receiver
YH67_RS09045	COG4191	Histidine kinase
YH67_RS09045	COG0784	Response regulator, receiver
YH67_RS09050	COG3437	response regulator, receiver
YH67_RS09050	COG3850	Histidine kinase
YH67_RS09050	COG4999	Histidine kinase
YH67_RS09050	COG2205	protein histidine kinase activity
YH67_RS09055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YH67_RS09065	COG5002	protein histidine kinase activity
YH67_RS09075	COG0640	Transcriptional regulator
YH67_RS09125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YH67_RS09130	COG0124	histidyl-tRNA synthetase
YH67_RS09145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
YH67_RS09150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YH67_RS09155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YH67_RS09160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YH67_RS09160	COG0131	Imidazoleglycerol-phosphate dehydratase
YH67_RS09165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YH67_RS09170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
YH67_RS09175	COG0107	imidazoleglycerol-phosphate synthase activity
YH67_RS09180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YH67_RS09180	COG0140	phosphoribosyl-ATP diphosphatase activity
YH67_RS09200	COG1446	asparaginase
YH67_RS09205	COG3142	Participates in the control of copper homeostasis
YH67_RS09220	COG0789	Transcriptional regulator
YH67_RS09235	COG3537	Alpha-1,2-mannosidase
YH67_RS09240	COG1609	Transcriptional regulator
YH67_RS09250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YH67_RS09265	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
YH67_RS09270	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
YH67_RS09275	COG0235	Class ii aldolase
YH67_RS09280	COG0531	amino acid
YH67_RS09285	COG0531	amino acid
YH67_RS09295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YH67_RS09300	COG0277	FAD linked oxidase domain protein
YH67_RS09315	COG2205	protein histidine kinase activity
YH67_RS09320	COG0745	RESPONSE REGULATOR receiver
YH67_RS09325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS09330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YH67_RS09350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YH67_RS09395	COG2249	NAD(P)H dehydrogenase (quinone) activity
YH67_RS09410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
YH67_RS09415	COG0505	Belongs to the CarA family
YH67_RS09420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YH67_RS09425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YH67_RS09445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YH67_RS09450	COG4676	Protein conserved in bacteria
YH67_RS09460	COG3279	Response regulator of the LytR AlgR family
YH67_RS09465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
YH67_RS09475	COG1012	belongs to the aldehyde dehydrogenase family
YH67_RS09495	COG2205	protein histidine kinase activity
YH67_RS09495	COG2198	Histidine kinase
YH67_RS09495	COG0784	Response regulator, receiver
YH67_RS09500	COG1024	Enoyl-CoA hydratase
YH67_RS09505	COG0318	PFAM AMP-dependent synthetase and ligase
YH67_RS09510	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
YH67_RS09515	COG1012	belongs to the aldehyde dehydrogenase family
YH67_RS09520	COG1309	transcriptional regulator
YH67_RS09525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YH67_RS09560	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
YH67_RS09570	COG0840	transmembrane signaling receptor activity
YH67_RS09575	COG0840	transmembrane signaling receptor activity
YH67_RS09585	COG0835	chemotaxis
YH67_RS09590	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
YH67_RS09595	COG0840	transmembrane signaling receptor activity
YH67_RS09605	COG0745	RESPONSE REGULATOR receiver
YH67_RS09615	COG0835	chemotaxis
YH67_RS09625	COG1360	Flagellar Motor Protein
YH67_RS09630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YH67_RS09635	COG2198	Histidine kinase
YH67_RS09635	COG0784	Response regulator, receiver
YH67_RS09635	COG0643	Histidine kinase
YH67_RS09640	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YH67_RS09665	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YH67_RS09670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YH67_RS09685	COG1987	bacterial-type flagellum assembly
YH67_RS09695	COG3190	flagellar
YH67_RS09745	COG1677	Flagellar hook-basal body complex protein FliE
YH67_RS09765	COG2197	response regulator
YH67_RS09785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
YH67_RS09825	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
YH67_RS09835	COG4787	bacterial-type flagellum-dependent cell motility
YH67_RS09850	COG1558	bacterial-type flagellum-dependent cell motility
YH67_RS09855	COG1815	bacterial-type flagellum-dependent cell motility
YH67_RS09860	COG0835	chemotaxis
YH67_RS09860	COG0784	Response regulator, receiver
YH67_RS09880	COG5002	protein histidine kinase activity
YH67_RS09915	COG2915	High frequency lysogenization protein hflD homolog
YH67_RS09920	COG0482	sulfurtransferase activity
YH67_RS09935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
YH67_RS09945	COG0542	response to heat
YH67_RS09980	COG0492	ferredoxin-NADP+ reductase activity
YH67_RS09985	COG1674	ftsk spoiiie
YH67_RS09995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
YH67_RS10000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YH67_RS10020	COG2819	hydrolase of the alpha beta superfamily
YH67_RS10030	COG4558	Periplasmic binding protein
YH67_RS10035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YH67_RS10040	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YH67_RS10050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YH67_RS10065	COG5002	protein histidine kinase activity
YH67_RS10065	COG0784	Response regulator, receiver
YH67_RS10100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YH67_RS10110	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
YH67_RS10125	COG1595	DNA-templated transcription, initiation
YH67_RS10145	COG0784	Response regulator, receiver
YH67_RS10150	COG4251	negative regulation of phosphorylation
YH67_RS10160	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
YH67_RS10260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
YH67_RS10265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
YH67_RS10270	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
YH67_RS10275	COG2080	2 iron, 2 sulfur cluster binding
YH67_RS10285	COG1764	response to oxidative stress
YH67_RS10295	COG0583	DNA-binding transcription factor activity
YH67_RS10315	COG1595	DNA-templated transcription, initiation
YH67_RS10320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YH67_RS10395	COG3685	Protein conserved in bacteria
YH67_RS10420	COG3546	catalase activity
YH67_RS10425	COG3685	Protein conserved in bacteria
YH67_RS10445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YH67_RS10465	COG1063	alcohol dehydrogenase
YH67_RS10490	COG1609	Transcriptional regulator
YH67_RS10495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YH67_RS10495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YH67_RS10500	COG1105	Belongs to the carbohydrate kinase PfkB family
YH67_RS10505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YH67_RS10505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YH67_RS10525	COG2211	Major facilitator Superfamily
YH67_RS10530	COG1472	Belongs to the glycosyl hydrolase 3 family
YH67_RS10545	COG3661	Belongs to the glycosyl hydrolase 67 family
YH67_RS10555	COG1472	Belongs to the glycosyl hydrolase 3 family
YH67_RS10560	COG0477	Major facilitator Superfamily
YH67_RS10570	COG1070	Carbohydrate kinase
YH67_RS10595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
YH67_RS10620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YH67_RS10635	COG2828	Protein conserved in bacteria
YH67_RS10640	COG0583	DNA-binding transcription factor activity
YH67_RS10660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
YH67_RS10665	COG0583	DNA-binding transcription factor activity
YH67_RS10680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
YH67_RS10710	COG0642	Histidine kinase
YH67_RS10720	COG0318	PFAM AMP-dependent synthetase and ligase
YH67_RS10730	COG5265	(ABC) transporter
YH67_RS10770	COG2186	Transcriptional regulator
YH67_RS10790	COG2271	Major facilitator Superfamily
YH67_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS10830	COG1404	Belongs to the peptidase S8 family
YH67_RS10845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YH67_RS10860	COG2226	methyltransferase
YH67_RS10870	COG0583	DNA-binding transcription factor activity
YH67_RS10895	COG2204	response regulator
YH67_RS10960	COG5002	protein histidine kinase activity
YH67_RS10960	COG5001	Diguanylate cyclase
YH67_RS10960	COG3447	MASE1 domain protein
YH67_RS10965	COG0577	efflux transmembrane transporter activity
YH67_RS10965	COG1136	(ABC) transporter
YH67_RS10970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS10980	COG0745	RESPONSE REGULATOR receiver
YH67_RS10985	COG2205	protein histidine kinase activity
YH67_RS10995	COG3214	Protein conserved in bacteria
YH67_RS11005	COG4774	siderophore transport
YH67_RS11030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
YH67_RS11035	COG1285	pathogenesis
YH67_RS11040	COG4191	Histidine kinase
YH67_RS11045	COG4566	intracellular signal transduction
YH67_RS11115	COG0477	Major facilitator Superfamily
YH67_RS11155	COG4771	TonB-dependent receptor
YH67_RS11180	COG5002	protein histidine kinase activity
YH67_RS11185	COG0583	DNA-binding transcription factor activity
YH67_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS11215	COG0642	Histidine kinase
YH67_RS11220	COG3537	Alpha-1,2-mannosidase
YH67_RS11225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YH67_RS11240	COG0477	Major facilitator Superfamily
YH67_RS11255	COG3920	Histidine kinase
YH67_RS11255	COG2202	Pas domain
YH67_RS11320	COG0811	peptide transport
YH67_RS11445	COG0840	transmembrane signaling receptor activity
YH67_RS11450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
YH67_RS11460	COG4149	molybdate abc transporter
YH67_RS11465	COG0725	ABC transporter, periplasmic molybdate-binding protein
YH67_RS11470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YH67_RS11485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YH67_RS11490	COG2181	nitrate reductase activity
YH67_RS11495	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
YH67_RS11500	COG1140	nitrate reductase beta subunit
YH67_RS11505	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
YH67_RS11510	COG2223	nitrite transmembrane transporter activity
YH67_RS11520	COG0746	molybdenum cofactor guanylyltransferase activity
YH67_RS11525	COG0314	molybdopterin synthase activity
YH67_RS11535	COG0303	'Molybdopterin
YH67_RS11540	COG0521	Mo-molybdopterin cofactor biosynthetic process
YH67_RS11540	COG0315	cyclic pyranopterin monophosphate synthase activity
YH67_RS11545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YH67_RS11585	COG2207	Transcriptional regulator
YH67_RS11625	COG2205	protein histidine kinase activity
YH67_RS11635	COG2194	sulfuric ester hydrolase activity
YH67_RS11655	COG2885	chlorophyll binding
YH67_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS11680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YH67_RS11680	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
YH67_RS11685	COG3433	isochorismatase activity
YH67_RS11685	COG1535	isochorismatase
YH67_RS11690	COG1535	isochorismatase
YH67_RS11690	COG3433	isochorismatase activity
YH67_RS11695	COG1021	2,3-dihydroxybenzoate-AMP ligase
YH67_RS11710	COG2409	Drug exporters of the RND superfamily
YH67_RS11715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YH67_RS11775	COG1914	H( )-stimulated, divalent metal cation uptake system
YH67_RS11790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YH67_RS11795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YH67_RS11800	COG0604	alcohol dehydrogenase
YH67_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS11800	COG3321	synthase
YH67_RS11805	COG4206	TonB-dependent receptor
YH67_RS11810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YH67_RS11845	COG0583	DNA-binding transcription factor activity
YH67_RS11855	COG4772	TonB-dependent receptor
YH67_RS11875	COG2226	methyltransferase
YH67_RS11920	COG4964	Belongs to the GSP D family
YH67_RS11975	COG2814	Major facilitator Superfamily
YH67_RS11985	COG1228	amidohydrolase
YH67_RS11995	COG1335	isochorismatase
YH67_RS12010	COG3850	Histidine kinase
YH67_RS12015	COG2197	response regulator
YH67_RS12020	COG2814	Major facilitator Superfamily
YH67_RS12030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
YH67_RS12040	COG0583	DNA-binding transcription factor activity
YH67_RS12055	COG3161	chorismate lyase activity
YH67_RS12095	COG0277	FAD linked oxidase domain protein
YH67_RS12100	COG1304	FMN binding
YH67_RS12105	COG2186	Transcriptional regulator
YH67_RS12115	COG1285	pathogenesis
YH67_RS12140	COG2814	Major facilitator Superfamily
YH67_RS12195	COG0587	DNA-directed DNA polymerase activity
YH67_RS12210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YH67_RS12215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
YH67_RS12215	COG0519	Catalyzes the synthesis of GMP from XMP
YH67_RS12230	COG1595	DNA-templated transcription, initiation
YH67_RS12240	COG4206	TonB-dependent receptor
YH67_RS12240	COG1629	transport
YH67_RS12270	COG0531	amino acid
YH67_RS12285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YH67_RS12295	COG0789	Transcriptional regulator
YH67_RS12360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YH67_RS12365	COG3706	GGDEF domain
YH67_RS12390	COG3447	MASE1 domain protein
YH67_RS12390	COG5002	protein histidine kinase activity
YH67_RS12390	COG5001	Diguanylate cyclase
YH67_RS12395	COG2183	response to ionizing radiation
YH67_RS12420	COG3243	poly(R)-hydroxyalkanoic acid synthase
YH67_RS12440	COG0534	Mate efflux family protein
YH67_RS12460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
YH67_RS12470	COG0668	transmembrane transport
YH67_RS12475	COG1902	pentaerythritol trinitrate reductase activity
YH67_RS12485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YH67_RS12495	COG1733	regulation of RNA biosynthetic process
YH67_RS12500	COG2249	NAD(P)H dehydrogenase (quinone) activity
YH67_RS12505	COG0456	acetyltransferase
YH67_RS12585	COG2948	multi-organism process
YH67_RS12595	COG3736	Type IV secretory pathway, component VirB8
YH67_RS12615	COG2814	Major facilitator Superfamily
YH67_RS12620	COG0789	Transcriptional regulator
YH67_RS12645	COG4191	Histidine kinase
YH67_RS12645	COG0784	Response regulator, receiver
YH67_RS12660	COG4774	siderophore transport
YH67_RS12670	COG0745	RESPONSE REGULATOR receiver
YH67_RS12705	COG1733	regulation of RNA biosynthetic process
YH67_RS12710	COG0604	alcohol dehydrogenase
YH67_RS12720	COG0210	DNA helicase
YH67_RS12735	COG0583	DNA-binding transcription factor activity
YH67_RS12740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
YH67_RS12750	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
YH67_RS12765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
YH67_RS12770	COG1605	Chorismate mutase
YH67_RS12770	COG0077	Prephenate dehydratase
YH67_RS12775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
YH67_RS12810	COG1228	amidohydrolase
YH67_RS12825	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
YH67_RS12880	COG2957	Belongs to the agmatine deiminase family
YH67_RS12885	COG0583	DNA-binding transcription factor activity
YH67_RS12940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
YH67_RS12950	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
YH67_RS12960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
YH67_RS12965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YH67_RS12980	COG0359	binds to the 23S rRNA
YH67_RS12985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YH67_RS12990	COG0360	Binds together with S18 to 16S ribosomal RNA
YH67_RS12995	COG0316	Belongs to the HesB IscA family
YH67_RS13000	COG0017	Asparaginyl-tRNA synthetase
YH67_RS13020	COG0288	reversible hydration of carbon dioxide
YH67_RS13030	COG3844	kynureninase activity
YH67_RS13035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YH67_RS13040	COG2925	Exonuclease
YH67_RS13050	COG0667	Aldo Keto reductase
YH67_RS13070	COG2902	Dehydrogenase
YH67_RS13080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS13085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YH67_RS13095	COG1960	acyl-CoA dehydrogenase activity
YH67_RS13110	COG1410	methionine synthase
YH67_RS13110	COG0646	methionine synthase
YH67_RS13120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
YH67_RS13120	COG2755	lipolytic protein G-D-S-L family
YH67_RS13130	COG2900	Belongs to the SlyX family
YH67_RS13145	COG0386	Belongs to the glutathione peroxidase family
YH67_RS13150	COG1725	Transcriptional regulator
YH67_RS13155	COG1131	(ABC) transporter
YH67_RS13190	COG2850	peptidyl-arginine hydroxylation
YH67_RS13200	COG0567	Dehydrogenase, E1 component
YH67_RS13225	COG3540	Alkaline phosphatase
YH67_RS13235	COG0305	Participates in initiation and elongation during chromosome replication
YH67_RS13255	COG0625	glutathione transferase activity
YH67_RS13275	COG0084	hydrolase, TatD family'
YH67_RS13280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YH67_RS13315	COG0625	glutathione transferase activity
YH67_RS13335	COG1595	DNA-templated transcription, initiation
YH67_RS13340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YH67_RS13355	COG0386	Belongs to the glutathione peroxidase family
YH67_RS13360	COG0339	signal peptide processing
YH67_RS13365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YH67_RS13385	COG0705	Rhomboid family
YH67_RS13390	COG3104	oligopeptide transport
YH67_RS13400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YH67_RS13405	COG4290	ribonuclease
YH67_RS13420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
YH67_RS13420	COG0316	Belongs to the HesB IscA family
YH67_RS13425	COG2154	pterin-4-alpha-carbinolamine dehydratase
YH67_RS13435	COG0428	transporter
YH67_RS13445	COG1530	ribonuclease E activity
YH67_RS13460	COG0395	ABC-type sugar transport system, permease component
YH67_RS13490	COG0271	Belongs to the BolA IbaG family
YH67_RS13495	COG2350	Protein conserved in bacteria
YH67_RS13500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
YH67_RS13505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
YH67_RS13510	COG1187	pseudouridine synthase activity
YH67_RS13520	COG2814	Major facilitator Superfamily
YH67_RS13545	COG0436	Aminotransferase
YH67_RS13550	COG4133	protoheme IX ABC transporter activity
YH67_RS13570	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
YH67_RS13585	COG4235	cytochrome complex assembly
YH67_RS13585	COG3088	subunit of a heme lyase
YH67_RS13595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YH67_RS13605	COG1132	(ABC) transporter
YH67_RS13610	COG4988	ABC transporter
YH67_RS13620	COG1294	oxidase, subunit
YH67_RS13650	COG0726	polysaccharide deacetylase
YH67_RS13650	COG1649	PFAM Uncharacterised BCR, COG1649
YH67_RS13655	COG1215	transferase activity, transferring glycosyl groups
YH67_RS13665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
YH67_RS13680	COG0165	Argininosuccinate lyase
YH67_RS13685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YH67_RS13695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YH67_RS13700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YH67_RS13705	COG0137	argininosuccinate synthase activity
YH67_RS13710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YH67_RS13725	COG2166	iron-sulfur cluster assembly
YH67_RS13745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
YH67_RS13765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YH67_RS13770	COG0402	S-adenosylhomocysteine deaminase activity
YH67_RS13775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YH67_RS13780	COG1509	lysine 2,3-aminomutase activity
YH67_RS13785	COG5001	Diguanylate cyclase
YH67_RS13785	COG3300	MHYT domain
YH67_RS13805	COG0501	Belongs to the peptidase M48B family
YH67_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS13835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YH67_RS13840	COG0860	N-Acetylmuramoyl-L-alanine amidase
YH67_RS13845	COG0802	atpase or kinase
YH67_RS13850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YH67_RS13850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YH67_RS13855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YH67_RS13860	COG1570	exodeoxyribonuclease VII activity
YH67_RS13870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
YH67_RS13885	COG4771	TonB-dependent receptor
YH67_RS13890	COG1309	transcriptional regulator
YH67_RS13930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YH67_RS13930	COG2169	Transcriptional regulator
YH67_RS13935	COG2130	NADP-dependent
YH67_RS13960	COG1960	acyl-CoA dehydrogenase activity
YH67_RS13970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
YH67_RS14000	COG1309	transcriptional regulator
YH67_RS14005	COG2076	Multidrug Resistance protein
YH67_RS14010	COG1280	lysine exporter protein (LysE YggA)
YH67_RS14015	COG0740	serine-type endopeptidase activity
YH67_RS14030	COG1794	racemase activity, acting on amino acids and derivatives
YH67_RS14050	COG0456	acetyltransferase
YH67_RS14050	COG0454	-acetyltransferase
YH67_RS14065	COG0776	regulation of translation
YH67_RS14070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YH67_RS14070	COG0072	phenylalanine-tRNA ligase activity
YH67_RS14075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
YH67_RS14080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
YH67_RS14085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
YH67_RS14090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YH67_RS14120	COG1185	polyribonucleotide nucleotidyltransferase activity
YH67_RS14125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
YH67_RS14130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
YH67_RS14135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
YH67_RS14140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YH67_RS14145	COG0195	Participates in both transcription termination and antitermination
YH67_RS14150	COG0779	Required for maturation of 30S ribosomal subunits
YH67_RS14165	COG1007	ATP synthesis coupled electron transport
YH67_RS14180	COG0713	ATP synthesis coupled electron transport
YH67_RS14190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YH67_RS14195	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
YH67_RS14210	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
YH67_RS14215	COG0649	NAD binding
YH67_RS14220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YH67_RS14225	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YH67_RS14230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YH67_RS14245	COG0149	triose-phosphate isomerase activity
YH67_RS14255	COG3119	arylsulfatase activity
YH67_RS14260	COG0438	transferase activity, transferring glycosyl groups
YH67_RS14265	COG0726	polysaccharide deacetylase
YH67_RS14270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YH67_RS14275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
YH67_RS14280	COG0159	tryptophan synthase activity
YH67_RS14290	COG0133	tryptophan synthase activity
YH67_RS14300	COG0860	N-Acetylmuramoyl-L-alanine amidase
YH67_RS14300	COG3409	Peptidoglycan-binding domain 1 protein
YH67_RS14310	COG0135	phosphoribosylanthranilate isomerase activity
YH67_RS14315	COG0101	tRNA pseudouridine synthase activity
YH67_RS14330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YH67_RS14335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YH67_RS14340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
YH67_RS14345	COG2890	protein-(glutamine-N5) methyltransferase activity
YH67_RS14350	COG1999	signal sequence binding
YH67_RS14355	COG0688	phosphatidylethanolamine metabolic process
YH67_RS14370	COG0433	COG0433 Predicted ATPase
YH67_RS14375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YH67_RS14385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YH67_RS14390	COG0412	Dienelactone hydrolase
YH67_RS14400	COG0717	Belongs to the dCTP deaminase family
YH67_RS14405	COG0489	protein tyrosine kinase activity
YH67_RS14410	COG4771	TonB-dependent receptor
YH67_RS14415	COG4771	TonB-dependent receptor
YH67_RS14425	COG4771	TonB-dependent receptor
YH67_RS14430	COG3590	peptidase
YH67_RS14460	COG0697	spore germination
YH67_RS14470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YH67_RS14475	COG2311	Membrane
YH67_RS14480	COG1047	Peptidyl-prolyl cis-trans
YH67_RS14485	COG0791	NLP P60 protein
YH67_RS14490	COG0791	NLP P60 protein
YH67_RS14495	COG1301	dicarboxylic acid transport
YH67_RS14515	COG1722	exodeoxyribonuclease VII activity
YH67_RS14520	COG0142	geranyltranstransferase activity
YH67_RS14530	COG0312	modulator of DNA gyrase
YH67_RS14535	COG3028	Belongs to the UPF0307 family
YH67_RS14540	COG0312	modulator of DNA gyrase
YH67_RS14560	COG2968	Membrane
YH67_RS14570	COG4771	TonB-dependent receptor
YH67_RS14585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
YH67_RS14595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
YH67_RS14610	COG0495	leucyl-tRNA aminoacylation
YH67_RS14620	COG3118	belongs to the thioredoxin family
YH67_RS14630	COG4251	negative regulation of phosphorylation
YH67_RS14630	COG5001	Diguanylate cyclase
YH67_RS14630	COG3706	GGDEF domain
YH67_RS14630	COG2203	Gaf domain
YH67_RS14655	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YH67_RS14665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YH67_RS14670	COG0346	lactoylglutathione lyase activity
YH67_RS14680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YH67_RS14680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YH67_RS14690	COG2878	Part of a membrane complex involved in electron transport
YH67_RS14695	COG0251	oxidation-reduction process
YH67_RS14700	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
YH67_RS14700	COG0392	lysyltransferase activity
YH67_RS14730	COG2824	Alkylphosphonate utilization operon protein PhnA
YH67_RS14735	COG0443	Heat shock 70 kDa protein
YH67_RS14775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
YH67_RS14780	COG3122	Protein conserved in bacteria
YH67_RS14785	COG1451	nucleotide metabolic process
YH67_RS14795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YH67_RS14815	COG0183	Belongs to the thiolase family
YH67_RS14830	COG1960	acyl-CoA dehydrogenase activity
YH67_RS14840	COG1793	dna ligase
YH67_RS14845	COG1201	RNA secondary structure unwinding
YH67_RS14860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YH67_RS14865	COG1278	Cold shock
YH67_RS14870	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
YH67_RS14875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
YH67_RS14880	COG1472	Belongs to the glycosyl hydrolase 3 family
YH67_RS14885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
YH67_RS14890	COG2954	triphosphatase activity
YH67_RS14895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YH67_RS14900	COG0745	RESPONSE REGULATOR receiver
YH67_RS14905	COG1381	Involved in DNA repair and RecF pathway recombination
YH67_RS14910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
YH67_RS14925	COG0681	Belongs to the peptidase S26 family
YH67_RS14930	COG0481	GTPase activity
YH67_RS14935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YH67_RS14955	COG1741	Belongs to the pirin family
YH67_RS14960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YH67_RS14970	COG1741	Belongs to the pirin family
YH67_RS14975	COG1966	Carbon starvation protein
YH67_RS14980	COG2879	small protein
YH67_RS14995	COG2205	protein histidine kinase activity
YH67_RS15000	COG0745	RESPONSE REGULATOR receiver
YH67_RS15035	COG2814	Major facilitator Superfamily
YH67_RS15040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YH67_RS15040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YH67_RS15050	COG1113	amino acid transport
YH67_RS15055	COG2207	Transcriptional regulator
YH67_RS15055	COG1917	Cupin 2, conserved barrel domain protein
YH67_RS15060	COG0753	catalase activity
YH67_RS15075	COG1376	ErfK ybiS ycfS ynhG family protein
YH67_RS15080	COG0739	heme binding
YH67_RS15090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
YH67_RS15100	COG0330	HflC and HflK could
YH67_RS15105	COG0330	HflC and HflK could
YH67_RS15110	COG0604	alcohol dehydrogenase
YH67_RS15125	COG0678	peroxiredoxin activity
YH67_RS15135	COG4953	penicillin-binding protein 1C
YH67_RS15140	COG2373	Large extracellular alpha-helical protein
YH67_RS15145	COG2079	MmgE PrpD family protein
YH67_RS15150	COG2828	Protein conserved in bacteria
YH67_RS15160	COG3609	addiction module antidote protein, CC2985 family
YH67_RS15180	COG3829	transcription factor binding
YH67_RS15185	COG0259	pyridoxamine-phosphate oxidase activity
YH67_RS15200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
YH67_RS15220	COG0477	Major facilitator Superfamily
YH67_RS15225	COG2198	Histidine kinase
YH67_RS15225	COG0784	Response regulator, receiver
YH67_RS15225	COG5002	protein histidine kinase activity
YH67_RS15230	COG5002	protein histidine kinase activity
YH67_RS15230	COG0784	Response regulator, receiver
YH67_RS15240	COG3038	cytochrome b561
YH67_RS15255	COG1760	l-serine dehydratase
YH67_RS15260	COG2267	carboxylic ester hydrolase activity
YH67_RS15265	COG0527	aspartate kinase activity
YH67_RS15265	COG0460	homoserine dehydrogenase
YH67_RS15270	COG0626	cystathionine gamma-synthase activity
YH67_RS15275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YH67_RS15280	COG0739	heme binding
YH67_RS15285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
YH67_RS15290	COG1272	protein, Hemolysin III
YH67_RS15295	COG2982	Protein involved in outer membrane biogenesis
YH67_RS15305	COG0463	Glycosyl transferase, family 2
YH67_RS15310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YH67_RS15315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
YH67_RS15325	COG4771	TonB-dependent receptor
YH67_RS15330	COG1309	transcriptional regulator
YH67_RS15370	COG0583	DNA-binding transcription factor activity
YH67_RS15380	COG0509	glycine decarboxylation via glycine cleavage system
YH67_RS15385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
YH67_RS15395	COG0330	HflC and HflK could
YH67_RS15405	COG1742	UPF0060 membrane protein
YH67_RS15410	COG3956	TIGRFAM MazG family protein
YH67_RS15415	COG1218	3'(2'),5'-bisphosphate nucleotidase
YH67_RS15420	COG0494	nUDIX hydrolase
YH67_RS15430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YH67_RS15445	COG0784	Response regulator, receiver
YH67_RS15445	COG0643	Histidine kinase
YH67_RS15445	COG2198	Histidine kinase
YH67_RS15450	COG0840	transmembrane signaling receptor activity
YH67_RS15455	COG0835	chemotaxis
YH67_RS15470	COG0189	ligase activity
YH67_RS15485	COG1199	ATP-dependent helicase activity
YH67_RS15495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YH67_RS15500	COG1216	Glycosyl transferase, family 2
YH67_RS15510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YH67_RS15520	COG1643	Atp-dependent helicase
YH67_RS15525	COG0783	Belongs to the Dps family
YH67_RS15530	COG0514	ATP-dependent DNA helicase (RecQ)
YH67_RS15540	COG2132	Multicopper oxidase
YH67_RS15625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YH67_RS15630	COG0602	queuosine metabolic process
YH67_RS15640	COG2885	chlorophyll binding
YH67_RS15645	COG0823	Involved in the tonB-independent uptake of proteins
YH67_RS15660	COG0811	peptide transport
YH67_RS15665	COG0824	Thioesterase
YH67_RS15670	COG2255	four-way junction helicase activity
YH67_RS15680	COG0632	four-way junction helicase activity
YH67_RS15685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
YH67_RS15690	COG0217	transcriptional regulatory protein
YH67_RS15710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
YH67_RS15740	COG0488	(ABC) transporter
YH67_RS15750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YH67_RS15750	COG4651	solute:proton antiporter activity
YH67_RS15760	COG0745	RESPONSE REGULATOR receiver
YH67_RS15765	COG2205	protein histidine kinase activity
YH67_RS15775	COG0542	response to heat
YH67_RS15795	COG0028	Belongs to the TPP enzyme family
YH67_RS15820	COG3387	PFAM Glycoside hydrolase 15-related
YH67_RS15825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
YH67_RS15830	COG3011	Protein conserved in bacteria
YH67_RS15845	COG0564	pseudouridine synthase activity
YH67_RS15850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YH67_RS15860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YH67_RS15860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YH67_RS15870	COG0045	succinate-CoA ligase (ADP-forming) activity
YH67_RS15905	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
YH67_RS15920	COG2205	protein histidine kinase activity
YH67_RS15925	COG0745	RESPONSE REGULATOR receiver
YH67_RS15940	COG0189	ligase activity
YH67_RS15965	COG3152	Membrane
YH67_RS15980	COG4625	pathogenesis
YH67_RS15980	COG3240	lipase activity
YH67_RS15990	COG2022	thiamine diphosphate biosynthetic process
YH67_RS15995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
YH67_RS16000	COG0471	metal ion transport
YH67_RS16000	COG3273	potassium ion transport
YH67_RS16020	COG1970	mechanosensitive ion channel activity
YH67_RS16030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YH67_RS16035	COG1115	amino acid carrier protein
YH67_RS16040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YH67_RS16045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YH67_RS16050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS16075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YH67_RS16085	COG3588	fructose-bisphosphate aldolase
YH67_RS16090	COG0469	pyruvate kinase activity
YH67_RS16100	COG0126	phosphoglycerate kinase activity
YH67_RS16115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
YH67_RS16120	COG3047	cAMP biosynthetic process
YH67_RS16160	COG3093	addiction module antidote protein HigA
YH67_RS16170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YH67_RS16175	COG1301	dicarboxylic acid transport
YH67_RS16185	COG2304	oxidoreductase activity
YH67_RS16205	COG0714	Associated with various cellular activities
YH67_RS16235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YH67_RS16250	COG5295	Hep Hag repeat protein
YH67_RS16290	COG0254	rRNA binding
YH67_RS16300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YH67_RS16310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YH67_RS16315	COG1758	RNA polymerase activity
YH67_RS16325	COG3383	formate dehydrogenase (NAD+) activity
YH67_RS16325	COG0243	molybdopterin cofactor binding
YH67_RS16330	COG0243	molybdopterin cofactor binding
YH67_RS16330	COG3383	formate dehydrogenase (NAD+) activity
YH67_RS16335	COG0437	4 iron, 4 sulfur cluster binding
YH67_RS16340	COG2864	formate dehydrogenase
YH67_RS16350	COG1921	L-seryl-tRNASec selenium transferase activity
YH67_RS16355	COG3276	selenocysteine insertion sequence binding
YH67_RS16365	COG0709	Synthesizes selenophosphate from selenide and ATP
YH67_RS16370	COG1561	YicC-like family, N-terminal region
YH67_RS16375	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
YH67_RS16380	COG0346	lactoylglutathione lyase activity
YH67_RS16390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YH67_RS16405	COG0006	proline dipeptidase activity
YH67_RS16410	COG0006	proline dipeptidase activity
YH67_RS16415	COG3079	Belongs to the UPF0149 family
YH67_RS16430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YH67_RS16440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
YH67_RS16450	COG2912	Transglutaminase-like superfamily
YH67_RS16455	COG1773	rubredoxin
YH67_RS16465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YH67_RS16470	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
YH67_RS16480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YH67_RS16485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YH67_RS16495	COG4221	oxidoreductase activity
YH67_RS16520	COG0671	phosphoesterase, PA-phosphatase related
YH67_RS16530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YH67_RS16535	COG0563	adenylate kinase activity
YH67_RS16555	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
YH67_RS16565	COG0848	biopolymer transport protein
YH67_RS16575	COG2832	Protein of unknown function (DUF454)
YH67_RS16610	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YH67_RS16620	COG4771	TonB-dependent receptor
YH67_RS16630	COG0745	RESPONSE REGULATOR receiver
YH67_RS16640	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
YH67_RS16645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YH67_RS16650	COG0405	Gamma-glutamyltransferase
YH67_RS16655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
YH67_RS16675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YH67_RS16680	COG2226	methyltransferase
YH67_RS16695	COG0473	3-isopropylmalate dehydrogenase activity
YH67_RS16710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YH67_RS16715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS16730	COG1538	Outer membrane efflux protein
YH67_RS16735	COG0531	amino acid
YH67_RS16740	COG1519	Transferase
YH67_RS16745	COG1560	Kdo2-lipid A biosynthetic process
YH67_RS16780	COG1301	dicarboxylic acid transport
YH67_RS16790	COG4191	Histidine kinase
YH67_RS16805	COG0642	Histidine kinase
YH67_RS16820	COG2851	Citrate transporter
YH67_RS16825	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS16845	COG1162	GTPase activity
YH67_RS16850	COG0436	Aminotransferase
YH67_RS16860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
YH67_RS16870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YH67_RS16885	COG1228	amidohydrolase
YH67_RS16890	COG0804	urea catabolic process
YH67_RS16900	COG1307	EDD domain protein, DegV family
YH67_RS16940	COG2203	Gaf domain
YH67_RS16940	COG3706	GGDEF domain
YH67_RS16940	COG5001	Diguanylate cyclase
YH67_RS16940	COG4251	negative regulation of phosphorylation
YH67_RS16945	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
YH67_RS16955	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
YH67_RS16965	COG4206	TonB-dependent receptor
YH67_RS16975	COG1902	pentaerythritol trinitrate reductase activity
YH67_RS16995	COG0583	DNA-binding transcription factor activity
YH67_RS17000	COG1064	alcohol dehydrogenase
YH67_RS17020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
YH67_RS17025	COG0218	Necessary for normal cell division and for the maintenance of normal septation
YH67_RS17040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YH67_RS17055	COG1522	sequence-specific DNA binding
YH67_RS17065	COG4773	Receptor
YH67_RS17090	COG0617	tRNA 3'-terminal CCA addition
YH67_RS17115	COG3468	outer membrane autotransporter barrel domain protein
YH67_RS17125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YH67_RS17130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YH67_RS17135	COG1609	Transcriptional regulator
YH67_RS17145	COG0837	glucose binding
YH67_RS17155	COG3525	Glycosyl hydrolase, family 20, catalytic domain
YH67_RS17175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YH67_RS17185	COG4191	Histidine kinase
YH67_RS17190	COG0784	Response regulator, receiver
YH67_RS17195	COG4251	negative regulation of phosphorylation
YH67_RS17200	COG2823	Periplasmic or secreted lipoprotein
YH67_RS17205	COG0673	inositol 2-dehydrogenase activity
YH67_RS17210	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
YH67_RS17230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
YH67_RS17235	COG0321	lipoyl(octanoyl) transferase activity
YH67_RS17240	COG2921	Belongs to the UPF0250 family
YH67_RS17250	COG1686	Belongs to the peptidase S11 family
YH67_RS17255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YH67_RS17260	COG2951	lytic endotransglycosylase activity
YH67_RS17270	COG0772	Belongs to the SEDS family
YH67_RS17275	COG0772	Belongs to the SEDS family
YH67_RS17280	COG0768	penicillin binding
YH67_RS17290	COG1792	Involved in formation and maintenance of cell shape
YH67_RS17295	COG1077	Cell shape determining protein MreB Mrl
YH67_RS17300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YH67_RS17315	COG0308	aminopeptidase N
YH67_RS17320	COG2226	methyltransferase
YH67_RS17345	COG1943	Transposase
YH67_RS17355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YH67_RS17360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS17370	COG0673	inositol 2-dehydrogenase activity
YH67_RS17380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
YH67_RS17400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
YH67_RS17410	COG2832	Protein of unknown function (DUF454)
YH67_RS17420	COG0436	Aminotransferase
YH67_RS17425	COG1505	serine-type exopeptidase activity
YH67_RS17450	COG0697	spore germination
YH67_RS17455	COG1666	GTP binding
YH67_RS17485	COG0339	signal peptide processing
YH67_RS17495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YH67_RS17515	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YH67_RS17525	COG1136	(ABC) transporter
YH67_RS17530	COG1136	(ABC) transporter
YH67_RS17530	COG0577	efflux transmembrane transporter activity
YH67_RS17535	COG0577	efflux transmembrane transporter activity
YH67_RS17545	COG2204	response regulator
YH67_RS17550	COG4191	Histidine kinase
YH67_RS17560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
YH67_RS17570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
YH67_RS17575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
YH67_RS17580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
YH67_RS17585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
YH67_RS17590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
YH67_RS17595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
YH67_RS17605	COG0356	it plays a direct role in the translocation of protons across the membrane
YH67_RS17620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YH67_RS17625	COG0508	dehydrogenase complex catalyzes the overall conversion of
YH67_RS17645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YH67_RS17670	COG0181	hydroxymethylbilane synthase activity
YH67_RS17680	COG2972	Histidine kinase
YH67_RS17680	COG0745	RESPONSE REGULATOR receiver
YH67_RS17695	COG4771	TonB-dependent receptor
YH67_RS17705	COG0840	transmembrane signaling receptor activity
YH67_RS17735	COG0477	Major facilitator Superfamily
YH67_RS17760	COG0583	DNA-binding transcription factor activity
YH67_RS17765	COG0477	Major facilitator Superfamily
YH67_RS17800	COG0625	glutathione transferase activity
YH67_RS17805	COG2259	Doxx family
YH67_RS17850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YH67_RS17855	COG1490	D-aminoacyl-tRNA deacylase activity
YH67_RS17900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
YH67_RS17900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
YH67_RS17905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
YH67_RS17910	COG0242	peptide deformylase activity
YH67_RS17920	COG0758	DNA mediated transformation
YH67_RS17925	COG2922	Belongs to the Smg family
YH67_RS17935	COG1714	RDD family
YH67_RS17940	COG1754	DNA topoisomerase type I activity
YH67_RS17940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YH67_RS17945	COG0009	L-threonylcarbamoyladenylate synthase
YH67_RS17960	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS17970	COG0616	signal peptide processing
YH67_RS17975	COG0534	Mate efflux family protein
YH67_RS17990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YH67_RS17995	COG0625	glutathione transferase activity
YH67_RS18005	COG1252	NADH dehydrogenase
YH67_RS18020	COG2860	membrane
YH67_RS18030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YH67_RS18050	COG1846	Transcriptional regulator
YH67_RS18080	COG0459	protein refolding
YH67_RS18085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
YH67_RS18090	COG2356	endonuclease I
YH67_RS18095	COG1324	tolerance protein
YH67_RS18105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YH67_RS18115	COG0840	transmembrane signaling receptor activity
YH67_RS18135	COG4585	Histidine kinase
YH67_RS18155	COG0583	DNA-binding transcription factor activity
YH67_RS18170	COG1686	Belongs to the peptidase S11 family
YH67_RS18180	COG2249	NAD(P)H dehydrogenase (quinone) activity
YH67_RS18190	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
YH67_RS18200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
YH67_RS18210	COG0511	ligase activity, forming carbon-carbon bonds
YH67_RS18215	COG0439	Biotin carboxylase
YH67_RS18230	COG2264	protein methyltransferase activity
YH67_RS18240	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
YH67_RS18245	COG4589	Belongs to the CDS family
YH67_RS18260	COG0671	phosphoesterase, PA-phosphatase related
YH67_RS18260	COG2453	phosphatase
YH67_RS18265	COG2267	carboxylic ester hydrolase activity
YH67_RS18270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YH67_RS18275	COG0138	bifunctional purine biosynthesis protein purh
YH67_RS18285	COG0151	Belongs to the GarS family
YH67_RS18300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YH67_RS18305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YH67_RS18310	COG2201	protein-glutamate methylesterase activity
YH67_RS18315	COG2177	Part of the ABC transporter FtsEX involved in
YH67_RS18320	COG2884	Cell division ATP-binding protein ftsE
YH67_RS18330	COG3118	belongs to the thioredoxin family
YH67_RS18335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YH67_RS18340	COG3706	GGDEF domain
YH67_RS18350	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
YH67_RS18385	COG1652	LysM domain
YH67_RS18390	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
YH67_RS18390	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
YH67_RS18395	COG1473	amidohydrolase
YH67_RS18400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS18405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YH67_RS18420	COG1289	transmembrane transporter activity
YH67_RS18425	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS18430	COG2814	Major facilitator Superfamily
YH67_RS18460	COG0316	Belongs to the HesB IscA family
YH67_RS18485	COG5002	protein histidine kinase activity
YH67_RS18485	COG2205	protein histidine kinase activity
YH67_RS18485	COG0784	Response regulator, receiver
YH67_RS18505	COG1051	belongs to the nudix hydrolase family
YH67_RS18520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
YH67_RS18525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
YH67_RS18530	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
YH67_RS18540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
YH67_RS18545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YH67_RS18550	COG0730	response to heat
YH67_RS18560	COG0134	indole-3-glycerol-phosphate synthase activity
YH67_RS18565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YH67_RS18595	COG1597	lipid kinase activity
YH67_RS18610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YH67_RS18615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
YH67_RS18625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YH67_RS18625	COG2111	Na H antiporter
YH67_RS18630	COG1006	Multisubunit Na H antiporter MnhC subunit
YH67_RS18635	COG0651	ATP synthesis coupled electron transport
YH67_RS18640	COG1863	multisubunit Na H antiporter MnhE subunit
YH67_RS18645	COG2212	antiporter activity
YH67_RS18650	COG1320	monovalent cation:proton antiporter activity
YH67_RS18655	COG0530	calcium, potassium:sodium antiporter activity
YH67_RS18670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
YH67_RS18685	COG4804	nuclease activity
YH67_RS18700	COG3104	oligopeptide transport
YH67_RS18705	COG3483	tryptophan 2,3-dioxygenase activity
YH67_RS18740	COG2378	regulation of single-species biofilm formation
YH67_RS18755	COG2354	Protein conserved in bacteria
YH67_RS18760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YH67_RS18765	COG1368	sulfuric ester hydrolase activity
YH67_RS18770	COG3264	Mechanosensitive ion channel
YH67_RS18770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
YH67_RS18785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YH67_RS18820	COG1166	arginine decarboxylase activity
YH67_RS18825	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
YH67_RS18845	COG2960	long-chain fatty acid transporting porin activity
YH67_RS18880	COG0606	chelatase, subunit chli
YH67_RS18950	COG0606	chelatase, subunit chli
YH67_RS18965	COG0561	phosphatase activity
YH67_RS18970	COG3932	Exopolysaccharide synthesis, ExoD
YH67_RS18995	COG1999	signal sequence binding
YH67_RS19000	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YH67_RS19005	COG1845	cytochrome c oxidase, subunit III
YH67_RS19015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YH67_RS19020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YH67_RS19035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YH67_RS19065	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
YH67_RS19085	COG2031	fatty acid transporter
YH67_RS19150	COG0673	inositol 2-dehydrogenase activity
YH67_RS19160	COG1501	Belongs to the glycosyl hydrolase 31 family
YH67_RS19165	COG2222	sugar isomerase
YH67_RS19170	COG1940	carbohydrate kinase activity
YH67_RS19180	COG1349	DNA-binding transcription factor activity
YH67_RS19185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YH67_RS19190	COG2814	Major facilitator Superfamily
YH67_RS19220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
YH67_RS19225	COG0156	8-amino-7-oxononanoate synthase activity
YH67_RS19230	COG2267	carboxylic ester hydrolase activity
YH67_RS19235	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS19250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YH67_RS19270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YH67_RS19275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YH67_RS19280	COG2205	protein histidine kinase activity
YH67_RS19285	COG0745	RESPONSE REGULATOR receiver
YH67_RS19290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YH67_RS19315	COG0714	Associated with various cellular activities
YH67_RS19330	COG0754	glutathionylspermidine amidase activity
YH67_RS19340	COG0129	dihydroxy-acid dehydratase activity
YH67_RS19350	COG1199	ATP-dependent helicase activity
YH67_RS19360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YH67_RS19380	COG3781	membrane
YH67_RS19410	COG0625	glutathione transferase activity
YH67_RS19430	COG2207	Transcriptional regulator
YH67_RS19445	COG4555	ABC transporter
YH67_RS19470	COG0543	2 iron, 2 sulfur cluster binding
YH67_RS19470	COG0633	Ferredoxin
YH67_RS19475	COG1131	(ABC) transporter
YH67_RS19480	COG0842	Transport permease protein
YH67_RS19490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YH67_RS19500	COG0084	hydrolase, TatD family'
YH67_RS19505	COG1643	Atp-dependent helicase
YH67_RS19515	COG1187	pseudouridine synthase activity
YH67_RS19530	COG0667	Aldo Keto reductase
YH67_RS19545	COG1690	Belongs to the RtcB family
YH67_RS19555	COG1959	2 iron, 2 sulfur cluster binding
YH67_RS19560	COG0840	transmembrane signaling receptor activity
YH67_RS19565	COG0583	DNA-binding transcription factor activity
YH67_RS19570	COG2814	Major facilitator Superfamily
YH67_RS19575	COG0656	L-ascorbic acid biosynthetic process
YH67_RS19580	COG2198	Histidine kinase
YH67_RS19580	COG2205	protein histidine kinase activity
YH67_RS19580	COG0784	Response regulator, receiver
YH67_RS19595	COG2267	carboxylic ester hydrolase activity
YH67_RS19600	COG0393	Putative heavy-metal-binding
YH67_RS19605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YH67_RS19605	COG1042	CoA-binding domain protein
YH67_RS19605	COG0045	succinate-CoA ligase (ADP-forming) activity
YH67_RS19610	COG2239	Acts as a magnesium transporter
YH67_RS19625	COG3100	YcgL domain-containing protein
YH67_RS19640	COG1028	Short-chain dehydrogenase reductase Sdr
YH67_RS19660	COG0644	oxidoreductase
YH67_RS19680	COG2986	histidine ammonia-lyase
YH67_RS19690	COG0463	Glycosyl transferase, family 2
YH67_RS19705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YH67_RS19710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YH67_RS19725	COG1294	oxidase, subunit
YH67_RS19730	COG1271	oxidase subunit
YH67_RS19765	COG1595	DNA-templated transcription, initiation
YH67_RS19780	COG0494	nUDIX hydrolase
YH67_RS19800	COG0408	coproporphyrinogen oxidase activity
YH67_RS19810	COG2323	membrane
YH67_RS19825	COG0589	response to stress
YH67_RS19845	COG0210	DNA helicase
YH67_RS19855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YH67_RS19860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
YH67_RS19865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
YH67_RS19880	COG0251	oxidation-reduction process
YH67_RS19920	COG0463	Glycosyl transferase, family 2
YH67_RS19935	COG1475	DNA binding
YH67_RS19940	COG1192	Involved in chromosome partitioning
YH67_RS19945	COG0357	Ribosomal RNA small subunit methyltransferase G
YH67_RS19950	COG2091	lysine biosynthetic process via aminoadipic acid
YH67_RS19990	COG1943	Transposase
YH67_RS19995	COG1971	Probably functions as a manganese efflux pump
YH67_RS20000	COG2205	protein histidine kinase activity
YH67_RS20000	COG0784	Response regulator, receiver
YH67_RS20010	COG2911	Protein conserved in bacteria
YH67_RS20015	COG0729	surface antigen
YH67_RS20025	COG0752	glycyl-tRNA synthetase alpha subunit
YH67_RS20030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YH67_RS20035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
YH67_RS20035	COG0519	Catalyzes the synthesis of GMP from XMP
YH67_RS20045	COG0805	protein transport
YH67_RS20055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YH67_RS20065	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
YH67_RS20070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
YH67_RS20070	COG0596	Alpha beta hydrolase
YH67_RS20075	COG0840	transmembrane signaling receptor activity
YH67_RS20130	COG3135	benzoate transporter
YH67_RS20145	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
YH67_RS20150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
YH67_RS20155	COG3706	GGDEF domain
YH67_RS20185	COG0302	gtp cyclohydrolase
YH67_RS20210	COG1289	transmembrane transporter activity
YH67_RS20225	COG1074	ATP-dependent DNA helicase activity
YH67_RS20230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YH67_RS20235	COG1127	ABC transporter
YH67_RS20240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YH67_RS20245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YH67_RS20260	COG2853	Lipoprotein
YH67_RS20265	COG0386	Belongs to the glutathione peroxidase family
YH67_RS20275	COG1322	Protein conserved in bacteria
YH67_RS20290	COG0583	DNA-binding transcription factor activity
YH67_RS20310	COG0667	Aldo Keto reductase
YH67_RS20315	COG0531	amino acid
YH67_RS20325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
YH67_RS20330	COG0861	Integral membrane protein TerC family
YH67_RS20340	COG0584	glycerophosphoryl diester phosphodiesterase
YH67_RS20365	COG0706	membrane insertase activity
YH67_RS20370	COG0594	ribonuclease P activity
YH67_RS20375	COG0230	Belongs to the bacterial ribosomal protein bL34 family