locus-tag	class	description
VN11_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VN11_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VN11_RS00020	COG0187	DNA topoisomerase II activity
VN11_RS00030	COG0501	Belongs to the peptidase M48B family
VN11_RS00060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VN11_RS00120	COG0659	secondary active sulfate transmembrane transporter activity
VN11_RS00135	COG0798	PFAM Bile acid sodium symporter
VN11_RS00150	COG0431	NADPH-dependent FMN reductase
VN11_RS00165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VN11_RS00180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VN11_RS00195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VN11_RS00195	COG3453	Protein conserved in bacteria
VN11_RS00210	COG0640	Transcriptional regulator
VN11_RS00230	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VN11_RS00240	COG4772	TonB-dependent receptor
VN11_RS00275	COG0800	Aldolase
VN11_RS00290	COG3186	Phenylalanine-4-hydroxylase
VN11_RS00295	COG1522	sequence-specific DNA binding
VN11_RS00300	COG1752	Esterase of the alpha-beta hydrolase superfamily
VN11_RS00310	COG4771	TonB-dependent receptor
VN11_RS00340	COG1122	ATPase activity
VN11_RS00355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VN11_RS00360	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VN11_RS00370	COG0210	DNA helicase
VN11_RS00390	COG3132	Protein of unknown function, DUF480
VN11_RS00395	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
VN11_RS00400	COG0284	orotidine-5'-phosphate decarboxylase activity
VN11_RS00405	COG5640	endopeptidase activity
VN11_RS00415	COG2937	Belongs to the GPAT DAPAT family
VN11_RS00425	COG0037	tRNA processing
VN11_RS00430	COG2974	May be involved in recombination
VN11_RS00440	COG1803	Methylglyoxal synthase
VN11_RS00445	COG2205	protein histidine kinase activity
VN11_RS00445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VN11_RS00450	COG0493	'glutamate synthase
VN11_RS00455	COG0067	glutamate synthase
VN11_RS00455	COG0069	glutamate synthase activity
VN11_RS00455	COG0070	glutamate synthase
VN11_RS00475	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS00555	COG1111	helicase
VN11_RS00555	COG1205	dead DEAH box helicase
VN11_RS00595	COG0714	Associated with various cellular activities
VN11_RS00615	COG0312	modulator of DNA gyrase
VN11_RS00635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VN11_RS00655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VN11_RS00660	COG2050	protein possibly involved in aromatic compounds catabolism
VN11_RS00680	COG1881	PFAM PEBP family protein
VN11_RS00695	COG1968	undecaprenyl-diphosphatase activity
VN11_RS00700	COG0174	glutamine synthetase
VN11_RS00705	COG0347	Belongs to the P(II) protein family
VN11_RS00710	COG0004	ammonium transporteR
VN11_RS00740	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VN11_RS00760	COG3852	Histidine kinase
VN11_RS00765	COG2204	response regulator
VN11_RS00770	COG2032	superoxide dismutase activity
VN11_RS00775	COG2032	superoxide dismutase activity
VN11_RS00785	COG0183	Belongs to the thiolase family
VN11_RS00820	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VN11_RS00825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VN11_RS00885	COG2837	iron assimilation
VN11_RS00920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VN11_RS00920	COG2205	protein histidine kinase activity
VN11_RS00925	COG3474	cytochrome
VN11_RS00935	COG1960	acyl-CoA dehydrogenase activity
VN11_RS00940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VN11_RS00950	COG0612	Peptidase, M16
VN11_RS00960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VN11_RS00965	COG0596	Alpha beta hydrolase
VN11_RS00975	COG0318	PFAM AMP-dependent synthetase and ligase
VN11_RS00980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VN11_RS00985	COG1181	Belongs to the D-alanine--D-alanine ligase family
VN11_RS00995	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VN11_RS01025	COG0339	signal peptide processing
VN11_RS01040	COG0681	Belongs to the peptidase S26 family
VN11_RS01045	COG2814	Major facilitator Superfamily
VN11_RS01050	COG0583	DNA-binding transcription factor activity
VN11_RS01055	COG0583	DNA-binding transcription factor activity
VN11_RS01060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VN11_RS01065	COG2224	Isocitrate lyase
VN11_RS01070	COG3706	GGDEF domain
VN11_RS01095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VN11_RS01100	COG1960	acyl-CoA dehydrogenase activity
VN11_RS01120	COG0697	spore germination
VN11_RS01130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VN11_RS01145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VN11_RS01155	COG1280	lysine exporter protein (LysE YggA)
VN11_RS01160	COG1607	acyl-coa hydrolase
VN11_RS01170	COG1902	pentaerythritol trinitrate reductase activity
VN11_RS01185	COG1335	isochorismatase
VN11_RS01190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VN11_RS01195	COG1752	Esterase of the alpha-beta hydrolase superfamily
VN11_RS01205	COG3800	Transcriptional regulator
VN11_RS01205	COG1396	sequence-specific DNA binding
VN11_RS01215	COG1960	acyl-CoA dehydrogenase activity
VN11_RS01220	COG1024	Enoyl-CoA hydratase
VN11_RS01225	COG1024	Enoyl-CoA hydratase
VN11_RS01235	COG1764	response to oxidative stress
VN11_RS01245	COG0659	secondary active sulfate transmembrane transporter activity
VN11_RS01255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VN11_RS01275	COG3228	Belongs to the MtfA family
VN11_RS01285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VN11_RS01285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VN11_RS01290	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VN11_RS01310	COG3657	addiction module killer protein
VN11_RS01345	COG3237	CsbD-like
VN11_RS01355	COG0180	Tryptophanyl-tRNA synthetase
VN11_RS01380	COG0477	Major facilitator Superfamily
VN11_RS01385	COG0697	spore germination
VN11_RS01405	COG1136	(ABC) transporter
VN11_RS01405	COG0577	efflux transmembrane transporter activity
VN11_RS01415	COG1136	(ABC) transporter
VN11_RS01420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS01425	COG1131	(ABC) transporter
VN11_RS01435	COG4585	Histidine kinase
VN11_RS01440	COG2197	response regulator
VN11_RS01450	COG0753	catalase activity
VN11_RS01455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VN11_RS01465	COG0628	permease
VN11_RS01485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VN11_RS01500	COG5507	3-demethylubiquinone-9 3-methyltransferase
VN11_RS01530	COG2814	Major facilitator Superfamily
VN11_RS01535	COG0583	DNA-binding transcription factor activity
VN11_RS01540	COG4807	Protein conserved in bacteria
VN11_RS01545	COG4221	oxidoreductase activity
VN11_RS01555	COG0018	arginyl-trna synthetase
VN11_RS01560	COG2003	Belongs to the UPF0758 family
VN11_RS01565	COG2197	response regulator
VN11_RS01570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VN11_RS01575	COG0756	dUTP diphosphatase activity
VN11_RS01590	COG2205	protein histidine kinase activity
VN11_RS01600	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
VN11_RS01605	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VN11_RS01620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VN11_RS01625	COG0708	Exodeoxyribonuclease III
VN11_RS01630	COG2211	Major facilitator Superfamily
VN11_RS01645	COG0739	heme binding
VN11_RS01650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VN11_RS01710	COG2234	aminopeptidase activity
VN11_RS01720	COG4942	peptidase
VN11_RS01725	COG0793	Belongs to the peptidase S41A family
VN11_RS01755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VN11_RS01800	COG0109	protoheme IX farnesyltransferase activity
VN11_RS01830	COG0358	DNA primase activity
VN11_RS01835	COG1295	ribonuclease BN
VN11_RS01850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VN11_RS01860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VN11_RS01865	COG0668	transmembrane transport
VN11_RS01880	COG2133	pyrroloquinoline quinone binding
VN11_RS01890	COG0531	amino acid
VN11_RS01900	COG1737	Transcriptional regulator
VN11_RS01905	COG4948	Mandelate Racemase Muconate Lactonizing
VN11_RS01955	COG5383	Protein conserved in bacteria
VN11_RS01965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VN11_RS01970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VN11_RS01995	COG0778	Nitroreductase
VN11_RS02000	COG2353	YceI-like domain
VN11_RS02015	COG2375	cellular response to nickel ion
VN11_RS02055	COG1401	restriction endodeoxyribonuclease activity
VN11_RS02090	COG2267	carboxylic ester hydrolase activity
VN11_RS02145	COG0488	(ABC) transporter
VN11_RS02150	COG0583	DNA-binding transcription factor activity
VN11_RS02160	COG2814	Major facilitator Superfamily
VN11_RS02165	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VN11_RS02170	COG1113	amino acid transport
VN11_RS02175	COG0741	lytic transglycosylase activity
VN11_RS02200	COG2764	glyoxalase bleomycin resistance protein dioxygenase
VN11_RS02210	COG5507	3-demethylubiquinone-9 3-methyltransferase
VN11_RS02215	COG4941	Belongs to the sigma-70 factor family
VN11_RS02225	COG3275	phosphorelay sensor kinase activity
VN11_RS02230	COG3279	Response regulator of the LytR AlgR family
VN11_RS02245	COG1309	transcriptional regulator
VN11_RS02255	COG2814	Major facilitator Superfamily
VN11_RS02260	COG3590	peptidase
VN11_RS02265	COG5001	Diguanylate cyclase
VN11_RS02270	COG0583	DNA-binding transcription factor activity
VN11_RS02280	COG3384	dioxygenase
VN11_RS02285	COG0025	NhaP-type Na H and K H
VN11_RS02310	COG1360	Flagellar Motor Protein
VN11_RS02340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VN11_RS02355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VN11_RS02355	COG2205	protein histidine kinase activity
VN11_RS02370	COG2813	Specifically methylates the guanine in position
VN11_RS02375	COG1187	pseudouridine synthase activity
VN11_RS02380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VN11_RS02390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VN11_RS02395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VN11_RS02410	COG0583	DNA-binding transcription factor activity
VN11_RS02415	COG2226	methyltransferase
VN11_RS02425	COG4206	TonB-dependent receptor
VN11_RS02440	COG1956	GAF domain-containing protein
VN11_RS02445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VN11_RS02450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VN11_RS02455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VN11_RS02460	COG0785	Cytochrome C biogenesis protein
VN11_RS02460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VN11_RS02465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VN11_RS02470	COG0745	RESPONSE REGULATOR receiver
VN11_RS02475	COG5002	protein histidine kinase activity
VN11_RS02480	COG2205	protein histidine kinase activity
VN11_RS02485	COG0745	RESPONSE REGULATOR receiver
VN11_RS02490	COG0367	asparagine synthase
VN11_RS02500	COG0720	synthase
VN11_RS02515	COG0513	Belongs to the DEAD box helicase family
VN11_RS02525	COG0625	glutathione transferase activity
VN11_RS02565	COG0626	cystathionine gamma-synthase activity
VN11_RS02595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VN11_RS02615	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VN11_RS02620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VN11_RS02655	COG1215	transferase activity, transferring glycosyl groups
VN11_RS02665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VN11_RS02670	COG0110	maltose O-acetyltransferase activity
VN11_RS02680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VN11_RS02690	COG2086	electron transfer activity
VN11_RS02730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VN11_RS02740	COG0277	FAD linked oxidase domain protein
VN11_RS02745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VN11_RS02765	COG1216	Glycosyl transferase, family 2
VN11_RS02780	COG1127	ABC transporter
VN11_RS02785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VN11_RS02800	COG0442	prolyl-tRNA aminoacylation
VN11_RS02810	COG1183	phosphatidylcholine synthase activity
VN11_RS02830	COG0525	valine-tRNA ligase activity
VN11_RS02840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VN11_RS02850	COG0795	lipopolysaccharide-transporting ATPase activity
VN11_RS02860	COG4974	Belongs to the 'phage' integrase family
VN11_RS02875	COG0047	phosphoribosylformylglycinamidine synthase activity
VN11_RS02875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VN11_RS02880	COG5295	Hep Hag repeat protein
VN11_RS02885	COG1404	Belongs to the peptidase S8 family
VN11_RS02890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VN11_RS02895	COG1459	type II secretion system
VN11_RS02900	COG2165	general secretion pathway protein
VN11_RS02905	COG4970	Tfp pilus assembly protein FimT
VN11_RS02910	COG2165	general secretion pathway protein
VN11_RS02915	COG4795	General secretion pathway protein
VN11_RS02920	COG3156	type II secretion system protein K
VN11_RS02925	COG3166	PFAM Fimbrial assembly family protein
VN11_RS02940	COG1450	Type ii and iii secretion system protein
VN11_RS02950	COG0463	Glycosyl transferase, family 2
VN11_RS02965	COG3539	Fimbrial protein
VN11_RS02970	COG3121	Chaperone
VN11_RS02995	COG2194	sulfuric ester hydrolase activity
VN11_RS03015	COG1215	transferase activity, transferring glycosyl groups
VN11_RS03020	COG0457	Tetratricopeptide repeat
VN11_RS03020	COG3118	belongs to the thioredoxin family
VN11_RS03025	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
VN11_RS03030	COG2252	PERMEase
VN11_RS03035	COG0488	(ABC) transporter
VN11_RS03045	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VN11_RS03065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VN11_RS03070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VN11_RS03070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VN11_RS03120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VN11_RS03125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VN11_RS03135	COG3152	Membrane
VN11_RS03140	COG3121	Chaperone
VN11_RS03175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VN11_RS03190	COG0277	FAD linked oxidase domain protein
VN11_RS03220	COG2001	Belongs to the MraZ family
VN11_RS03225	COG0275	rRNA processing
VN11_RS03230	COG3116	cell division
VN11_RS03245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VN11_RS03265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VN11_RS03270	COG1181	Belongs to the D-alanine--D-alanine ligase family
VN11_RS03275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VN11_RS03285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VN11_RS03290	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VN11_RS03300	COG0739	heme binding
VN11_RS03305	COG0653	protein targeting
VN11_RS03310	COG0494	nUDIX hydrolase
VN11_RS03320	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VN11_RS03325	COG2267	carboxylic ester hydrolase activity
VN11_RS03330	COG3275	phosphorelay sensor kinase activity
VN11_RS03340	COG0402	S-adenosylhomocysteine deaminase activity
VN11_RS03360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VN11_RS03370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VN11_RS03380	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VN11_RS03400	COG1607	acyl-coa hydrolase
VN11_RS03405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VN11_RS03425	COG4106	trans-aconitate 2-methyltransferase activity
VN11_RS03430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VN11_RS03455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VN11_RS03460	COG0667	Aldo Keto reductase
VN11_RS03470	COG4771	TonB-dependent receptor
VN11_RS03485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VN11_RS03490	COG4181	ATPase activity
VN11_RS03505	COG0642	Histidine kinase
VN11_RS03515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VN11_RS03520	COG0861	Integral membrane protein TerC family
VN11_RS03525	COG2814	Major facilitator Superfamily
VN11_RS03530	COG1704	LemA family
VN11_RS03545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VN11_RS03550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VN11_RS03560	COG3738	Protein conserved in bacteria
VN11_RS03565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VN11_RS03570	COG2967	ApaG domain
VN11_RS03575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VN11_RS03580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VN11_RS03585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VN11_RS03590	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VN11_RS03600	COG2096	Adenosyltransferase
VN11_RS03610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VN11_RS03615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VN11_RS03620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VN11_RS03625	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VN11_RS03645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VN11_RS03655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VN11_RS03665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VN11_RS03670	COG0583	DNA-binding transcription factor activity
VN11_RS03675	COG3634	alkyl hydroperoxide reductase activity
VN11_RS03685	COG2890	protein-(glutamine-N5) methyltransferase activity
VN11_RS03730	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VN11_RS03755	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VN11_RS03770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VN11_RS03790	COG1404	Belongs to the peptidase S8 family
VN11_RS03810	COG1295	ribonuclease BN
VN11_RS03815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VN11_RS03830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VN11_RS03835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VN11_RS03850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VN11_RS03860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VN11_RS03870	COG0193	aminoacyl-tRNA hydrolase activity
VN11_RS03875	COG0012	GTP binding
VN11_RS03885	COG4206	TonB-dependent receptor
VN11_RS03890	COG4242	Belongs to the peptidase S51 family
VN11_RS03915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VN11_RS03930	COG0250	Participates in transcription elongation, termination and antitermination
VN11_RS03935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VN11_RS03940	COG0081	regulation of translation
VN11_RS03945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VN11_RS03950	COG0222	ribosome binding
VN11_RS03955	COG0085	RNA polymerase activity
VN11_RS03960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VN11_RS03965	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VN11_RS03970	COG0049	tRNA binding
VN11_RS03975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VN11_RS03980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VN11_RS03985	COG0051	transcription antitermination factor activity, RNA binding
VN11_RS03990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VN11_RS03995	COG0088	Forms part of the polypeptide exit tunnel
VN11_RS04000	COG0089	rRNA binding
VN11_RS04005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VN11_RS04010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VN11_RS04015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VN11_RS04020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VN11_RS04025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VN11_RS04030	COG0255	Belongs to the universal ribosomal protein uL29 family
VN11_RS04035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VN11_RS04040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VN11_RS04045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VN11_RS04050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VN11_RS04055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VN11_RS04060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VN11_RS04065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VN11_RS04070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VN11_RS04075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VN11_RS04080	COG1841	ribosomal large subunit assembly
VN11_RS04085	COG0200	Binds to the 23S rRNA
VN11_RS04090	COG0201	protein transport
VN11_RS04095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VN11_RS04100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VN11_RS04105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VN11_RS04110	COG0202	RNA polymerase activity
VN11_RS04115	COG0203	ribosomal protein L17
VN11_RS04130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
VN11_RS04140	COG0154	amidase activity
VN11_RS04155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VN11_RS04160	COG0039	L-malate dehydrogenase activity
VN11_RS04165	COG0564	pseudouridine synthase activity
VN11_RS04170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VN11_RS04185	COG0625	glutathione transferase activity
VN11_RS04195	COG1902	pentaerythritol trinitrate reductase activity
VN11_RS04195	COG0446	pyridine nucleotide-disulphide oxidoreductase
VN11_RS04200	COG2364	Membrane
VN11_RS04205	COG0604	alcohol dehydrogenase
VN11_RS04220	COG1187	pseudouridine synthase activity
VN11_RS04240	COG1063	alcohol dehydrogenase
VN11_RS04250	COG0588	phosphoglycerate mutase activity
VN11_RS04255	COG0285	dihydrofolate synthase activity
VN11_RS04275	COG2833	Protein of unknown function (DUF455)
VN11_RS04285	COG3291	Pkd domain containing protein
VN11_RS04290	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VN11_RS04295	COG0671	phosphoesterase, PA-phosphatase related
VN11_RS04300	COG0438	transferase activity, transferring glycosyl groups
VN11_RS04305	COG4206	TonB-dependent receptor
VN11_RS04310	COG0248	Ppx GppA phosphatase
VN11_RS04315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VN11_RS04330	COG4783	chaperone-mediated protein folding
VN11_RS04345	COG0473	3-isopropylmalate dehydrogenase activity
VN11_RS04425	COG0592	DNA-directed DNA polymerase activity
VN11_RS04440	COG2204	response regulator
VN11_RS04455	COG3772	lysozyme
VN11_RS04580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VN11_RS04580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VN11_RS04655	COG0544	peptidyl-prolyl cis-trans isomerase activity
VN11_RS04660	COG0740	serine-type endopeptidase activity
VN11_RS04665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VN11_RS04705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VN11_RS04710	COG1388	LysM domain
VN11_RS04710	COG3942	CHAP domain
VN11_RS04715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VN11_RS04725	COG0328	RNA-DNA hybrid ribonuclease activity
VN11_RS04730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VN11_RS04735	COG0631	protein serine/threonine phosphatase activity
VN11_RS04750	COG0859	PFAM glycosyl transferase family 9
VN11_RS04755	COG3642	lipopolysaccharide core region biosynthetic process
VN11_RS04760	COG1234	tRNA 3'-trailer cleavage
VN11_RS04770	COG2076	Multidrug Resistance protein
VN11_RS04795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VN11_RS04800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VN11_RS04810	COG0537	adenosine 5'-monophosphoramidase activity
VN11_RS04830	COG0714	Associated with various cellular activities
VN11_RS04845	COG1399	metal-binding, possibly nucleic acid-binding protein
VN11_RS04850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VN11_RS04855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VN11_RS04865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VN11_RS04870	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS04880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VN11_RS04885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VN11_RS04890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VN11_RS04895	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VN11_RS04970	COG0582	viral genome integration into host DNA
VN11_RS05115	COG4774	siderophore transport
VN11_RS05125	COG2223	nitrite transmembrane transporter activity
VN11_RS05145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VN11_RS05150	COG0697	spore germination
VN11_RS05155	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS05160	COG0583	DNA-binding transcription factor activity
VN11_RS05165	COG0583	DNA-binding transcription factor activity
VN11_RS05170	COG0477	Major facilitator Superfamily
VN11_RS05210	COG0583	DNA-binding transcription factor activity
VN11_RS05220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VN11_RS05235	COG0667	Aldo Keto reductase
VN11_RS05255	COG0519	Catalyzes the synthesis of GMP from XMP
VN11_RS05260	COG1678	Uncharacterized ACR, COG1678
VN11_RS05265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VN11_RS05270	COG0540	Belongs to the ATCase OTCase family
VN11_RS05290	COG2239	Acts as a magnesium transporter
VN11_RS05295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VN11_RS05310	COG1660	Displays ATPase and GTPase activities
VN11_RS05315	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
VN11_RS05320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VN11_RS05325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VN11_RS05335	COG1137	ATPase activity
VN11_RS05350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VN11_RS05365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VN11_RS05385	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VN11_RS05400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VN11_RS05410	COG0628	permease
VN11_RS05420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VN11_RS05430	COG2261	transglycosylase associated protein
VN11_RS05440	COG1555	photosystem II stabilization
VN11_RS05460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VN11_RS05465	COG1477	protein flavinylation
VN11_RS05485	COG4771	TonB-dependent receptor
VN11_RS05495	COG3128	pkhd-type hydroxylase
VN11_RS05500	COG4774	siderophore transport
VN11_RS05505	COG2146	nitrite reductase [NAD(P)H] activity
VN11_RS05535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VN11_RS05540	COG0719	Fe-S assembly protein
VN11_RS05545	COG0396	ATPase activity
VN11_RS05550	COG0719	Fe-S assembly protein
VN11_RS05555	COG1959	2 iron, 2 sulfur cluster binding
VN11_RS05565	COG0693	protein deglycase activity
VN11_RS05590	COG1764	response to oxidative stress
VN11_RS05595	COG0384	phenazine biosynthesis protein PhzF
VN11_RS05600	COG0384	phenazine biosynthesis protein PhzF
VN11_RS05605	COG0527	aspartate kinase activity
VN11_RS05630	COG0142	geranyltranstransferase activity
VN11_RS05635	COG0366	Alpha amylase catalytic
VN11_RS05645	COG1082	Xylose isomerase domain protein TIM barrel
VN11_RS05655	COG2211	Major facilitator Superfamily
VN11_RS05655	COG2190	(PTS) system
VN11_RS05685	COG1131	(ABC) transporter
VN11_RS05695	COG0629	single-stranded DNA binding
VN11_RS05720	COG2010	Cytochrome c
VN11_RS05730	COG0673	inositol 2-dehydrogenase activity
VN11_RS05735	COG2211	Major facilitator Superfamily
VN11_RS05745	COG1609	Transcriptional regulator
VN11_RS05775	COG0583	DNA-binding transcription factor activity
VN11_RS05780	COG1073	alpha beta
VN11_RS05790	COG3655	Transcriptional regulator
VN11_RS05795	COG1253	flavin adenine dinucleotide binding
VN11_RS05800	COG1408	metallophosphoesterase
VN11_RS05820	COG2972	Histidine kinase
VN11_RS05830	COG0477	Major facilitator Superfamily
VN11_RS05845	COG1802	Transcriptional regulator
VN11_RS05880	COG3052	prosthetic group binding
VN11_RS05895	COG0579	oxidoreductase
VN11_RS05935	COG3104	oligopeptide transport
VN11_RS05950	COG1297	OPT oligopeptide transporter protein
VN11_RS05955	COG1506	peptidase
VN11_RS05955	COG0823	Involved in the tonB-independent uptake of proteins
VN11_RS05970	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VN11_RS05975	COG2894	cell division
VN11_RS05980	COG0850	regulation of cytokinetic process
VN11_RS05990	COG4585	Histidine kinase
VN11_RS05995	COG2197	response regulator
VN11_RS06020	COG1073	alpha beta
VN11_RS06040	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VN11_RS06050	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VN11_RS06060	COG1595	DNA-templated transcription, initiation
VN11_RS06070	COG1946	Acyl-CoA thioesterase
VN11_RS06090	COG0824	Thioesterase
VN11_RS06095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VN11_RS06100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VN11_RS06105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VN11_RS06110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VN11_RS06115	COG0268	Binds directly to 16S ribosomal RNA
VN11_RS06120	COG0728	peptidoglycan biosynthetic process
VN11_RS06125	COG0196	riboflavin kinase activity
VN11_RS06130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VN11_RS06140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VN11_RS06155	COG4206	TonB-dependent receptor
VN11_RS06175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VN11_RS06185	COG2801	Transposase and inactivated derivatives
VN11_RS06190	COG2963	transposase activity
VN11_RS06195	COG2963	transposase activity
VN11_RS06200	COG2801	Transposase and inactivated derivatives
VN11_RS06220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VN11_RS06225	COG1845	cytochrome c oxidase, subunit III
VN11_RS06230	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VN11_RS06245	COG0326	Molecular chaperone. Has ATPase activity
VN11_RS06265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VN11_RS06285	COG0228	four-way junction DNA binding
VN11_RS06290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VN11_RS06295	COG0336	Belongs to the RNA methyltransferase TrmD family
VN11_RS06300	COG0335	large ribosomal subunit rRNA binding
VN11_RS06320	COG0534	Mate efflux family protein
VN11_RS06345	COG0753	catalase activity
VN11_RS06370	COG0840	transmembrane signaling receptor activity
VN11_RS06375	COG3134	Outer membrane lipoprotein
VN11_RS06395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS06415	COG0024	Methionine aminopeptidase
VN11_RS06440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VN11_RS06465	COG1647	Serine aminopeptidase, S33
VN11_RS06510	COG2814	Major facilitator Superfamily
VN11_RS06530	COG1515	deoxyribonuclease V activity
VN11_RS06535	COG0588	phosphoglycerate mutase activity
VN11_RS06540	COG3590	peptidase
VN11_RS06550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VN11_RS06560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VN11_RS06565	COG0745	RESPONSE REGULATOR receiver
VN11_RS06570	COG2205	protein histidine kinase activity
VN11_RS06575	COG4452	Inner membrane protein CreD
VN11_RS06590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VN11_RS06595	COG0735	belongs to the Fur family
VN11_RS06635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VN11_RS06675	COG5002	protein histidine kinase activity
VN11_RS06675	COG5001	Diguanylate cyclase
VN11_RS06680	COG2199	diguanylate cyclase activity
VN11_RS06685	COG1187	pseudouridine synthase activity
VN11_RS06695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VN11_RS06720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VN11_RS06725	COG1132	(ABC) transporter
VN11_RS06775	COG1695	Transcriptional regulator
VN11_RS06795	COG1981	membrane
VN11_RS06800	COG0825	malonyl-CoA metabolic process
VN11_RS06820	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VN11_RS06830	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VN11_RS06835	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VN11_RS06840	COG0750	zinc metalloprotease
VN11_RS06845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VN11_RS06850	COG0575	Belongs to the CDS family
VN11_RS06855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VN11_RS06860	COG0233	cytoplasmic translational termination
VN11_RS06865	COG0528	UMP kinase activity
VN11_RS06875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VN11_RS06880	COG0052	Belongs to the universal ribosomal protein uS2 family
VN11_RS06900	COG3188	usher protein
VN11_RS06920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VN11_RS06935	COG1393	Belongs to the ArsC family
VN11_RS06940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VN11_RS06950	COG0367	asparagine synthase
VN11_RS06985	COG1566	PFAM secretion protein HlyD family protein
VN11_RS06990	COG2814	Major facilitator Superfamily
VN11_RS07000	COG0583	DNA-binding transcription factor activity
VN11_RS07020	COG0557	exoribonuclease II activity
VN11_RS07030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VN11_RS07035	COG1538	Outer membrane efflux protein
VN11_RS07040	COG0577	efflux transmembrane transporter activity
VN11_RS07040	COG1136	(ABC) transporter
VN11_RS07045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS07065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VN11_RS07070	COG2259	Doxx family
VN11_RS07080	COG3220	belongs to the UPF0276 family
VN11_RS07090	COG0704	Plays a role in the regulation of phosphate uptake
VN11_RS07100	COG0581	inorganic phosphate transmembrane transporter activity
VN11_RS07105	COG0573	inorganic phosphate transmembrane transporter activity
VN11_RS07110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VN11_RS07115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VN11_RS07125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VN11_RS07135	COG1024	Enoyl-CoA hydratase
VN11_RS07145	COG0494	nUDIX hydrolase
VN11_RS07165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VN11_RS07165	COG0116	Belongs to the methyltransferase superfamily
VN11_RS07190	COG2733	membrane
VN11_RS07200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VN11_RS07205	COG1012	belongs to the aldehyde dehydrogenase family
VN11_RS07215	COG0477	Major facilitator Superfamily
VN11_RS07220	COG2703	oxygen carrier activity
VN11_RS07245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VN11_RS07250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VN11_RS07255	COG0174	glutamine synthetase
VN11_RS07265	COG3842	ATPase activity
VN11_RS07270	COG1176	ABC-type spermidine putrescine transport system, permease component I
VN11_RS07275	COG1177	transmembrane transport
VN11_RS07280	COG1012	belongs to the aldehyde dehydrogenase family
VN11_RS07295	COG4535	Mg2 and Co2 transporter CorC
VN11_RS07310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VN11_RS07315	COG1702	phosphate starvation-inducible protein PhoH
VN11_RS07325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VN11_RS07350	COG1131	(ABC) transporter
VN11_RS07355	COG0842	Transport permease protein
VN11_RS07360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VN11_RS07375	COG0741	lytic transglycosylase activity
VN11_RS07380	COG0723	plastoquinol--plastocyanin reductase activity
VN11_RS07385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VN11_RS07390	COG2857	Cytochrome c1
VN11_RS07395	COG0625	glutathione transferase activity
VN11_RS07400	COG2969	positive regulation of protein catabolic process
VN11_RS07435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VN11_RS07445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VN11_RS07460	COG1611	Belongs to the LOG family
VN11_RS07465	COG4969	Belongs to the N-Me-Phe pilin family
VN11_RS07505	COG0556	nucleotide-excision repair
VN11_RS07540	COG3713	MltA-interacting MipA family protein
VN11_RS07555	COG2333	competence protein COMEC
VN11_RS07555	COG0658	competence protein
VN11_RS07560	COG0811	peptide transport
VN11_RS07575	COG1663	tetraacyldisaccharide 4'-kinase activity
VN11_RS07580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VN11_RS07585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VN11_RS07595	COG0322	excinuclease ABC activity
VN11_RS07610	COG1959	2 iron, 2 sulfur cluster binding
VN11_RS07640	COG0577	efflux transmembrane transporter activity
VN11_RS07640	COG1136	(ABC) transporter
VN11_RS07690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VN11_RS07720	COG1917	Cupin 2, conserved barrel domain protein
VN11_RS07720	COG4977	sequence-specific DNA binding
VN11_RS07725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VN11_RS07740	COG0348	domain, Protein
VN11_RS07755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VN11_RS07775	COG0069	glutamate synthase activity
VN11_RS07805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VN11_RS07820	COG1253	flavin adenine dinucleotide binding
VN11_RS07830	COG0306	phosphate transporter
VN11_RS07840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VN11_RS07855	COG0504	CTP synthase activity
VN11_RS07860	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VN11_RS07875	COG0148	phosphopyruvate hydratase activity
VN11_RS07880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VN11_RS07885	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VN11_RS07890	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VN11_RS07900	COG2840	Smr protein MutS2
VN11_RS07905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VN11_RS07910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VN11_RS07935	COG1534	Rna-binding protein
VN11_RS07940	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VN11_RS07945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VN11_RS07955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VN11_RS07960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VN11_RS07965	COG1923	regulation of RNA biosynthetic process
VN11_RS07970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VN11_RS07975	COG1546	Belongs to the CinA family
VN11_RS07980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VN11_RS07985	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VN11_RS07990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VN11_RS07995	COG2137	regulation of response to DNA damage stimulus
VN11_RS08000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VN11_RS08005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VN11_RS08040	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VN11_RS08060	COG3540	Alkaline phosphatase
VN11_RS08080	COG3258	Cytochrome c
VN11_RS08095	COG2223	nitrite transmembrane transporter activity
VN11_RS08110	COG1741	Belongs to the pirin family
VN11_RS08115	COG0583	DNA-binding transcription factor activity
VN11_RS08140	COG0352	thiamine-phosphate diphosphorylase activity
VN11_RS08140	COG0351	phosphomethylpyrimidine kinase
VN11_RS08155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VN11_RS08160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VN11_RS08170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VN11_RS08180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VN11_RS08185	COG0477	Major facilitator Superfamily
VN11_RS08195	COG0617	tRNA 3'-terminal CCA addition
VN11_RS08200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VN11_RS08205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VN11_RS08210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VN11_RS08220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
VN11_RS08225	COG0166	Belongs to the GPI family
VN11_RS08240	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
VN11_RS08250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VN11_RS08255	COG0671	phosphoesterase, PA-phosphatase related
VN11_RS08265	COG0800	Aldolase
VN11_RS08270	COG0129	dihydroxy-acid dehydratase activity
VN11_RS08280	COG0837	glucose binding
VN11_RS08285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VN11_RS08290	COG3842	ATPase activity
VN11_RS08300	COG2009	succinate dehydrogenase
VN11_RS08305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VN11_RS08310	COG1053	succinate dehydrogenase
VN11_RS08330	COG4591	ABC-type transport system involved in lipoprotein release permease component
VN11_RS08345	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VN11_RS08355	COG0552	protein localization to endoplasmic reticulum
VN11_RS08370	COG0742	ribosomal rna small subunit methyltransferase
VN11_RS08375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VN11_RS08385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VN11_RS08390	COG0405	Gamma-glutamyltransferase
VN11_RS08395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VN11_RS08415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VN11_RS08435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VN11_RS08440	COG0415	Belongs to the DNA photolyase family
VN11_RS08445	COG2885	chlorophyll binding
VN11_RS08450	COG4221	oxidoreductase activity
VN11_RS08460	COG0583	DNA-binding transcription factor activity
VN11_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS08665	COG0305	Participates in initiation and elongation during chromosome replication
VN11_RS08705	COG3179	chitinase
VN11_RS08885	COG0582	viral genome integration into host DNA
VN11_RS08895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VN11_RS08905	COG2914	Belongs to the UPF0125 (RnfH) family
VN11_RS08910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VN11_RS08915	COG0735	belongs to the Fur family
VN11_RS08925	COG0583	DNA-binding transcription factor activity
VN11_RS08930	COG0497	DNA recombination
VN11_RS08935	COG1420	regulation of RNA biosynthetic process
VN11_RS08940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VN11_RS08945	COG0443	Heat shock 70 kDa protein
VN11_RS08950	COG0484	heat shock protein binding
VN11_RS08955	COG2207	Transcriptional regulator
VN11_RS08960	COG2223	nitrite transmembrane transporter activity
VN11_RS08970	COG0287	Prephenate dehydrogenase
VN11_RS08970	COG1605	Chorismate mutase
VN11_RS08980	COG1132	(ABC) transporter
VN11_RS09000	COG5001	Diguanylate cyclase
VN11_RS09000	COG2203	Gaf domain
VN11_RS09000	COG4251	negative regulation of phosphorylation
VN11_RS09000	COG3706	GGDEF domain
VN11_RS09010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VN11_RS09015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VN11_RS09030	COG0343	queuine tRNA-ribosyltransferase activity
VN11_RS09035	COG1862	Preprotein translocase
VN11_RS09040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VN11_RS09045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VN11_RS09050	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VN11_RS09060	COG2081	HI0933 family
VN11_RS09065	COG4681	YaeQ
VN11_RS09085	COG0625	glutathione transferase activity
VN11_RS09090	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VN11_RS09095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VN11_RS09100	COG0513	Belongs to the DEAD box helicase family
VN11_RS09110	COG0583	DNA-binding transcription factor activity
VN11_RS09115	COG0488	(ABC) transporter
VN11_RS09140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VN11_RS09155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VN11_RS09160	COG2957	Belongs to the agmatine deiminase family
VN11_RS09170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VN11_RS09175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VN11_RS09185	COG0776	regulation of translation
VN11_RS09195	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VN11_RS09200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VN11_RS09210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VN11_RS09215	COG0183	Belongs to the thiolase family
VN11_RS09220	COG1250	3-hydroxyacyl-CoA dehydrogenase
VN11_RS09220	COG1024	Enoyl-CoA hydratase
VN11_RS09230	COG0105	UTP biosynthetic process
VN11_RS09235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VN11_RS09245	COG1426	Protein conserved in bacteria
VN11_RS09250	COG2976	Protein conserved in bacteria
VN11_RS09255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VN11_RS09260	COG1160	GTP binding
VN11_RS09270	COG0583	DNA-binding transcription factor activity
VN11_RS09275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VN11_RS09280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VN11_RS09280	COG0475	glutathione-regulated potassium exporter activity
VN11_RS09295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VN11_RS09295	COG0519	Catalyzes the synthesis of GMP from XMP
VN11_RS09305	COG1204	response to ionizing radiation
VN11_RS09310	COG2963	transposase activity
VN11_RS09315	COG2801	Transposase and inactivated derivatives
VN11_RS09330	COG0583	DNA-binding transcription factor activity
VN11_RS09350	COG2801	Transposase and inactivated derivatives
VN11_RS09355	COG2963	transposase activity
VN11_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS09390	COG0640	Transcriptional regulator
VN11_RS09400	COG4716	Myosin-crossreactive antigen
VN11_RS09405	COG0300	oxidoreductase activity
VN11_RS09410	COG2207	Transcriptional regulator
VN11_RS09435	COG4206	TonB-dependent receptor
VN11_RS09440	COG0431	NADPH-dependent FMN reductase
VN11_RS09450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VN11_RS09455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VN11_RS09460	COG1473	amidohydrolase
VN11_RS09470	COG0765	amino acid transport
VN11_RS09475	COG1126	abc transporter atp-binding protein
VN11_RS09480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VN11_RS09495	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS09505	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS09520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VN11_RS09525	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS09535	COG1309	transcriptional regulator
VN11_RS09550	COG0697	spore germination
VN11_RS09555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VN11_RS09560	COG0167	dihydroorotate dehydrogenase activity
VN11_RS09575	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS09580	COG1012	belongs to the aldehyde dehydrogenase family
VN11_RS09590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VN11_RS09590	COG2755	lipolytic protein G-D-S-L family
VN11_RS09595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VN11_RS09600	COG0454	-acetyltransferase
VN11_RS09600	COG0456	acetyltransferase
VN11_RS09630	COG0745	RESPONSE REGULATOR receiver
VN11_RS09635	COG4191	Histidine kinase
VN11_RS09635	COG0784	Response regulator, receiver
VN11_RS09640	COG2205	protein histidine kinase activity
VN11_RS09640	COG4999	Histidine kinase
VN11_RS09640	COG3850	Histidine kinase
VN11_RS09640	COG3437	response regulator, receiver
VN11_RS09645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VN11_RS09655	COG2205	protein histidine kinase activity
VN11_RS09655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VN11_RS09665	COG0640	Transcriptional regulator
VN11_RS09700	COG0527	aspartate kinase activity
VN11_RS09700	COG0460	homoserine dehydrogenase
VN11_RS09710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VN11_RS09715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VN11_RS09720	COG0124	histidyl-tRNA synthetase
VN11_RS09735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VN11_RS09740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VN11_RS09745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VN11_RS09750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VN11_RS09750	COG0131	Imidazoleglycerol-phosphate dehydratase
VN11_RS09755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VN11_RS09760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VN11_RS09765	COG0107	imidazoleglycerol-phosphate synthase activity
VN11_RS09770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VN11_RS09770	COG0140	phosphoribosyl-ATP diphosphatase activity
VN11_RS09785	COG0837	glucose binding
VN11_RS09790	COG1446	asparaginase
VN11_RS09795	COG3142	Participates in the control of copper homeostasis
VN11_RS09815	COG0789	Transcriptional regulator
VN11_RS09830	COG3537	Alpha-1,2-mannosidase
VN11_RS09835	COG1609	Transcriptional regulator
VN11_RS09845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VN11_RS09860	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
VN11_RS09865	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
VN11_RS09870	COG0235	Class ii aldolase
VN11_RS09875	COG0531	amino acid
VN11_RS09880	COG0531	amino acid
VN11_RS09890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VN11_RS09895	COG0277	FAD linked oxidase domain protein
VN11_RS09910	COG2205	protein histidine kinase activity
VN11_RS09915	COG0745	RESPONSE REGULATOR receiver
VN11_RS09920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS09940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VN11_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS10000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VN11_RS10005	COG0505	Belongs to the CarA family
VN11_RS10010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VN11_RS10015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VN11_RS10025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VN11_RS10045	COG3209	COG3209 Rhs family protein
VN11_RS10065	COG3279	Response regulator of the LytR AlgR family
VN11_RS10070	COG0501	Belongs to the peptidase M48B family
VN11_RS10075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VN11_RS10085	COG1012	belongs to the aldehyde dehydrogenase family
VN11_RS10095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VN11_RS10105	COG2205	protein histidine kinase activity
VN11_RS10105	COG2198	Histidine kinase
VN11_RS10105	COG0784	Response regulator, receiver
VN11_RS10110	COG1024	Enoyl-CoA hydratase
VN11_RS10115	COG0318	PFAM AMP-dependent synthetase and ligase
VN11_RS10120	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
VN11_RS10125	COG1012	belongs to the aldehyde dehydrogenase family
VN11_RS10130	COG1309	transcriptional regulator
VN11_RS10135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VN11_RS10180	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VN11_RS10190	COG0840	transmembrane signaling receptor activity
VN11_RS10195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VN11_RS10205	COG0840	transmembrane signaling receptor activity
VN11_RS10215	COG0835	chemotaxis
VN11_RS10220	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
VN11_RS10225	COG0840	transmembrane signaling receptor activity
VN11_RS10235	COG0745	RESPONSE REGULATOR receiver
VN11_RS10245	COG0835	chemotaxis
VN11_RS10255	COG1360	Flagellar Motor Protein
VN11_RS10260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VN11_RS10265	COG2198	Histidine kinase
VN11_RS10265	COG0784	Response regulator, receiver
VN11_RS10265	COG0643	Histidine kinase
VN11_RS10270	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VN11_RS10295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VN11_RS10300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VN11_RS10315	COG1987	bacterial-type flagellum assembly
VN11_RS10325	COG3190	flagellar
VN11_RS10375	COG1677	Flagellar hook-basal body complex protein FliE
VN11_RS10395	COG2197	response regulator
VN11_RS10415	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VN11_RS10420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VN11_RS10440	COG1256	bacterial-type flagellum assembly
VN11_RS10455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VN11_RS10465	COG4787	bacterial-type flagellum-dependent cell motility
VN11_RS10485	COG1815	bacterial-type flagellum-dependent cell motility
VN11_RS10490	COG0784	Response regulator, receiver
VN11_RS10490	COG0835	chemotaxis
VN11_RS10510	COG5002	protein histidine kinase activity
VN11_RS10545	COG2915	High frequency lysogenization protein hflD homolog
VN11_RS10550	COG0482	sulfurtransferase activity
VN11_RS10565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VN11_RS10575	COG0542	response to heat
VN11_RS10615	COG0492	ferredoxin-NADP+ reductase activity
VN11_RS10620	COG1674	ftsk spoiiie
VN11_RS10635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VN11_RS10650	COG2819	hydrolase of the alpha beta superfamily
VN11_RS10660	COG4558	Periplasmic binding protein
VN11_RS10665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VN11_RS10670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VN11_RS10680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VN11_RS10700	COG2197	response regulator
VN11_RS10710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VN11_RS10725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VN11_RS10740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VN11_RS10750	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
VN11_RS10765	COG1595	DNA-templated transcription, initiation
VN11_RS10785	COG0784	Response regulator, receiver
VN11_RS10790	COG4251	negative regulation of phosphorylation
VN11_RS10800	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
VN11_RS10810	COG0454	-acetyltransferase
VN11_RS10810	COG0456	acetyltransferase
VN11_RS10830	COG4555	ABC transporter
VN11_RS10850	COG4644	lycopene metabolic process
VN11_RS10900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VN11_RS10925	COG2132	Multicopper oxidase
VN11_RS10980	COG0010	Belongs to the arginase family
VN11_RS10995	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VN11_RS11000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS11025	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VN11_RS11050	COG0704	Plays a role in the regulation of phosphate uptake
VN11_RS11065	COG0573	inorganic phosphate transmembrane transporter activity
VN11_RS11070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VN11_RS11085	COG0492	ferredoxin-NADP+ reductase activity
VN11_RS11090	COG0798	PFAM Bile acid sodium symporter
VN11_RS11105	COG0431	NADPH-dependent FMN reductase
VN11_RS11125	COG2072	flavoprotein involved in K transport
VN11_RS11130	COG2801	Transposase and inactivated derivatives
VN11_RS11135	COG2963	transposase activity
VN11_RS11140	COG2963	transposase activity
VN11_RS11165	COG0789	Transcriptional regulator
VN11_RS11210	COG3422	double-strand break repair
VN11_RS11255	COG1309	transcriptional regulator
VN11_RS11270	COG0789	Transcriptional regulator
VN11_RS11275	COG4771	TonB-dependent receptor
VN11_RS11285	COG2205	protein histidine kinase activity
VN11_RS11365	COG1595	DNA-templated transcription, initiation
VN11_RS11370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VN11_RS11375	COG2814	Major facilitator Superfamily
VN11_RS11395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VN11_RS11400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VN11_RS11405	COG0583	DNA-binding transcription factor activity
VN11_RS11435	COG2207	Transcriptional regulator
VN11_RS11450	COG0596	Alpha beta hydrolase
VN11_RS11470	COG0318	PFAM AMP-dependent synthetase and ligase
VN11_RS11505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VN11_RS11515	COG0346	lactoylglutathione lyase activity
VN11_RS11615	COG3604	Transcriptional regulator
VN11_RS11670	COG5001	Diguanylate cyclase
VN11_RS11670	COG3447	MASE1 domain protein
VN11_RS11670	COG5002	protein histidine kinase activity
VN11_RS11680	COG0577	efflux transmembrane transporter activity
VN11_RS11680	COG1136	(ABC) transporter
VN11_RS11685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS11690	COG0745	RESPONSE REGULATOR receiver
VN11_RS11695	COG2205	protein histidine kinase activity
VN11_RS11715	COG4774	siderophore transport
VN11_RS11735	COG3214	Protein conserved in bacteria
VN11_RS11745	COG4774	siderophore transport
VN11_RS11750	COG2205	protein histidine kinase activity
VN11_RS11750	COG0784	Response regulator, receiver
VN11_RS11790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VN11_RS11795	COG1285	pathogenesis
VN11_RS11800	COG4191	Histidine kinase
VN11_RS11805	COG4566	intracellular signal transduction
VN11_RS11865	COG0243	molybdopterin cofactor binding
VN11_RS11890	COG0477	Major facilitator Superfamily
VN11_RS11915	COG1136	(ABC) transporter
VN11_RS11930	COG4771	TonB-dependent receptor
VN11_RS11945	COG1276	copper resistance
VN11_RS11955	COG5002	protein histidine kinase activity
VN11_RS11960	COG0583	DNA-binding transcription factor activity
VN11_RS11990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VN11_RS12010	COG3537	Alpha-1,2-mannosidase
VN11_RS12035	COG0477	Major facilitator Superfamily
VN11_RS12050	COG3920	Histidine kinase
VN11_RS12095	COG1335	isochorismatase
VN11_RS12125	COG0811	peptide transport
VN11_RS12245	COG0840	transmembrane signaling receptor activity
VN11_RS12250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VN11_RS12270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VN11_RS12275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VN11_RS12280	COG1120	ATPase activity
VN11_RS12290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VN11_RS12295	COG4149	molybdate abc transporter
VN11_RS12300	COG0725	ABC transporter, periplasmic molybdate-binding protein
VN11_RS12305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VN11_RS12320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VN11_RS12325	COG2181	nitrate reductase activity
VN11_RS12330	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
VN11_RS12335	COG1140	nitrate reductase beta subunit
VN11_RS12340	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
VN11_RS12345	COG2223	nitrite transmembrane transporter activity
VN11_RS12355	COG0746	molybdenum cofactor guanylyltransferase activity
VN11_RS12360	COG0314	molybdopterin synthase activity
VN11_RS12370	COG0303	'Molybdopterin
VN11_RS12375	COG0315	cyclic pyranopterin monophosphate synthase activity
VN11_RS12375	COG0521	Mo-molybdopterin cofactor biosynthetic process
VN11_RS12380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VN11_RS12440	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS12445	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
VN11_RS12445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VN11_RS12455	COG1535	isochorismatase
VN11_RS12455	COG3433	isochorismatase activity
VN11_RS12460	COG1021	2,3-dihydroxybenzoate-AMP ligase
VN11_RS12475	COG2409	Drug exporters of the RND superfamily
VN11_RS12480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VN11_RS12540	COG1914	H( )-stimulated, divalent metal cation uptake system
VN11_RS12555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VN11_RS12560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VN11_RS12570	COG4206	TonB-dependent receptor
VN11_RS12575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VN11_RS12610	COG0583	DNA-binding transcription factor activity
VN11_RS12620	COG4772	TonB-dependent receptor
VN11_RS12640	COG2226	methyltransferase
VN11_RS12685	COG4964	Belongs to the GSP D family
VN11_RS12740	COG2814	Major facilitator Superfamily
VN11_RS12750	COG1228	amidohydrolase
VN11_RS12760	COG1335	isochorismatase
VN11_RS12775	COG3850	Histidine kinase
VN11_RS12780	COG2197	response regulator
VN11_RS12785	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
VN11_RS12795	COG0583	DNA-binding transcription factor activity
VN11_RS12810	COG3161	chorismate lyase activity
VN11_RS12815	COG4771	TonB-dependent receptor
VN11_RS12870	COG2885	chlorophyll binding
VN11_RS12915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VN11_RS12920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VN11_RS13030	COG0277	FAD linked oxidase domain protein
VN11_RS13035	COG1304	FMN binding
VN11_RS13040	COG2186	Transcriptional regulator
VN11_RS13050	COG1285	pathogenesis
VN11_RS13130	COG0587	DNA-directed DNA polymerase activity
VN11_RS13145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VN11_RS13160	COG1595	DNA-templated transcription, initiation
VN11_RS13170	COG1629	transport
VN11_RS13170	COG4206	TonB-dependent receptor
VN11_RS13195	COG0531	amino acid
VN11_RS13210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VN11_RS13390	COG4695	Portal protein
VN11_RS13630	COG0745	RESPONSE REGULATOR receiver
VN11_RS13635	COG5002	protein histidine kinase activity
VN11_RS13635	COG5001	Diguanylate cyclase
VN11_RS13635	COG3447	MASE1 domain protein
VN11_RS13640	COG2183	response to ionizing radiation
VN11_RS13655	COG1983	PspC domain protein
VN11_RS13665	COG3243	poly(R)-hydroxyalkanoic acid synthase
VN11_RS13685	COG0534	Mate efflux family protein
VN11_RS13705	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VN11_RS13715	COG0668	transmembrane transport
VN11_RS13720	COG1902	pentaerythritol trinitrate reductase activity
VN11_RS13730	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VN11_RS13740	COG1733	regulation of RNA biosynthetic process
VN11_RS13745	COG2249	NAD(P)H dehydrogenase (quinone) activity
VN11_RS13750	COG0456	acetyltransferase
VN11_RS13775	COG2814	Major facilitator Superfamily
VN11_RS13780	COG0789	Transcriptional regulator
VN11_RS13805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VN11_RS13815	COG4774	siderophore transport
VN11_RS13845	COG0577	efflux transmembrane transporter activity
VN11_RS13845	COG1136	(ABC) transporter
VN11_RS13875	COG1733	regulation of RNA biosynthetic process
VN11_RS13880	COG0604	alcohol dehydrogenase
VN11_RS13885	COG0210	DNA helicase
VN11_RS13905	COG0583	DNA-binding transcription factor activity
VN11_RS13910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VN11_RS13920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VN11_RS13935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VN11_RS13940	COG1605	Chorismate mutase
VN11_RS13940	COG0077	Prephenate dehydratase
VN11_RS13945	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VN11_RS13985	COG1228	amidohydrolase
VN11_RS14000	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VN11_RS14030	COG2957	Belongs to the agmatine deiminase family
VN11_RS14035	COG0583	DNA-binding transcription factor activity
VN11_RS14120	COG4993	Dehydrogenase
VN11_RS14130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
VN11_RS14140	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VN11_RS14150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VN11_RS14155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VN11_RS14175	COG0359	binds to the 23S rRNA
VN11_RS14180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VN11_RS14185	COG0360	Binds together with S18 to 16S ribosomal RNA
VN11_RS14190	COG0316	Belongs to the HesB IscA family
VN11_RS14195	COG0017	Asparaginyl-tRNA synthetase
VN11_RS14215	COG0288	reversible hydration of carbon dioxide
VN11_RS14225	COG3844	kynureninase activity
VN11_RS14230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VN11_RS14235	COG2925	Exonuclease
VN11_RS14260	COG2902	Dehydrogenase
VN11_RS14270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS14275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VN11_RS14280	COG1960	acyl-CoA dehydrogenase activity
VN11_RS14295	COG0646	methionine synthase
VN11_RS14295	COG1410	methionine synthase
VN11_RS14310	COG2900	Belongs to the SlyX family
VN11_RS14325	COG0386	Belongs to the glutathione peroxidase family
VN11_RS14335	COG1725	Transcriptional regulator
VN11_RS14340	COG1131	(ABC) transporter
VN11_RS14375	COG2850	peptidyl-arginine hydroxylation
VN11_RS14385	COG0567	Dehydrogenase, E1 component
VN11_RS14390	COG0508	dehydrogenase complex catalyzes the overall conversion of
VN11_RS14400	COG0583	DNA-binding transcription factor activity
VN11_RS14420	COG3540	Alkaline phosphatase
VN11_RS14430	COG0305	Participates in initiation and elongation during chromosome replication
VN11_RS14450	COG0625	glutathione transferase activity
VN11_RS14470	COG0084	hydrolase, TatD family'
VN11_RS14475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VN11_RS14510	COG0625	glutathione transferase activity
VN11_RS14530	COG1595	DNA-templated transcription, initiation
VN11_RS14535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VN11_RS14550	COG0386	Belongs to the glutathione peroxidase family
VN11_RS14555	COG0339	signal peptide processing
VN11_RS14560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VN11_RS14580	COG0705	Rhomboid family
VN11_RS14585	COG3104	oligopeptide transport
VN11_RS14595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VN11_RS14600	COG4290	ribonuclease
VN11_RS14615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VN11_RS14615	COG0316	Belongs to the HesB IscA family
VN11_RS14620	COG2154	pterin-4-alpha-carbinolamine dehydratase
VN11_RS14630	COG0428	transporter
VN11_RS14640	COG1530	ribonuclease E activity
VN11_RS14655	COG0395	ABC-type sugar transport system, permease component
VN11_RS14680	COG1609	Transcriptional regulator
VN11_RS14685	COG0271	Belongs to the BolA IbaG family
VN11_RS14690	COG2350	Protein conserved in bacteria
VN11_RS14695	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
VN11_RS14700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VN11_RS14705	COG1187	pseudouridine synthase activity
VN11_RS14720	COG0436	Aminotransferase
VN11_RS14725	COG4133	protoheme IX ABC transporter activity
VN11_RS14745	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VN11_RS14760	COG4235	cytochrome complex assembly
VN11_RS14760	COG3088	subunit of a heme lyase
VN11_RS14770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VN11_RS14780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VN11_RS14785	COG4988	ABC transporter
VN11_RS14795	COG1294	oxidase, subunit
VN11_RS14860	COG1649	PFAM Uncharacterised BCR, COG1649
VN11_RS14860	COG0726	polysaccharide deacetylase
VN11_RS14865	COG1215	transferase activity, transferring glycosyl groups
VN11_RS14875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VN11_RS14890	COG0165	Argininosuccinate lyase
VN11_RS14895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VN11_RS14905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VN11_RS14910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VN11_RS14915	COG0137	argininosuccinate synthase activity
VN11_RS14920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VN11_RS14935	COG2166	iron-sulfur cluster assembly
VN11_RS14955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VN11_RS14975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VN11_RS14980	COG0402	S-adenosylhomocysteine deaminase activity
VN11_RS14985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VN11_RS14990	COG1509	lysine 2,3-aminomutase activity
VN11_RS14995	COG3300	MHYT domain
VN11_RS14995	COG5001	Diguanylate cyclase
VN11_RS15010	COG0483	inositol monophosphate 1-phosphatase activity
VN11_RS15015	COG0501	Belongs to the peptidase M48B family
VN11_RS15025	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS15045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VN11_RS15050	COG0860	N-Acetylmuramoyl-L-alanine amidase
VN11_RS15055	COG0802	atpase or kinase
VN11_RS15060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VN11_RS15060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VN11_RS15065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VN11_RS15070	COG1570	exodeoxyribonuclease VII activity
VN11_RS15080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VN11_RS15095	COG4771	TonB-dependent receptor
VN11_RS15100	COG1309	transcriptional regulator
VN11_RS15130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VN11_RS15130	COG2169	Transcriptional regulator
VN11_RS15135	COG2130	NADP-dependent
VN11_RS15150	COG3040	lipid binding
VN11_RS15160	COG1960	acyl-CoA dehydrogenase activity
VN11_RS15170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VN11_RS15185	COG2197	response regulator
VN11_RS15245	COG1309	transcriptional regulator
VN11_RS15250	COG2076	Multidrug Resistance protein
VN11_RS15255	COG1280	lysine exporter protein (LysE YggA)
VN11_RS15260	COG1794	racemase activity, acting on amino acids and derivatives
VN11_RS15275	COG0456	acetyltransferase
VN11_RS15275	COG0454	-acetyltransferase
VN11_RS15290	COG0776	regulation of translation
VN11_RS15295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VN11_RS15295	COG0072	phenylalanine-tRNA ligase activity
VN11_RS15300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VN11_RS15305	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VN11_RS15310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VN11_RS15315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VN11_RS15320	COG4774	siderophore transport
VN11_RS15365	COG1185	polyribonucleotide nucleotidyltransferase activity
VN11_RS15370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VN11_RS15380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VN11_RS15385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VN11_RS15390	COG0195	Participates in both transcription termination and antitermination
VN11_RS15395	COG0779	Required for maturation of 30S ribosomal subunits
VN11_RS15410	COG1007	ATP synthesis coupled electron transport
VN11_RS15425	COG0713	ATP synthesis coupled electron transport
VN11_RS15435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VN11_RS15440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VN11_RS15455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
VN11_RS15460	COG0649	NAD binding
VN11_RS15465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VN11_RS15470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VN11_RS15475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VN11_RS15490	COG0149	triose-phosphate isomerase activity
VN11_RS15500	COG3083	sulfuric ester hydrolase activity
VN11_RS15505	COG0438	transferase activity, transferring glycosyl groups
VN11_RS15510	COG0726	polysaccharide deacetylase
VN11_RS15520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VN11_RS15525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VN11_RS15530	COG0159	tryptophan synthase activity
VN11_RS15540	COG0133	tryptophan synthase activity
VN11_RS15575	COG0135	phosphoribosylanthranilate isomerase activity
VN11_RS15580	COG0101	tRNA pseudouridine synthase activity
VN11_RS15595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VN11_RS15600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VN11_RS15605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VN11_RS15610	COG2890	protein-(glutamine-N5) methyltransferase activity
VN11_RS15615	COG1999	signal sequence binding
VN11_RS15620	COG0688	phosphatidylethanolamine metabolic process
VN11_RS15635	COG0433	COG0433 Predicted ATPase
VN11_RS15640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VN11_RS15650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VN11_RS15655	COG0412	Dienelactone hydrolase
VN11_RS15665	COG0717	Belongs to the dCTP deaminase family
VN11_RS15670	COG0489	protein tyrosine kinase activity
VN11_RS15675	COG4771	TonB-dependent receptor
VN11_RS15680	COG4771	TonB-dependent receptor
VN11_RS15700	COG3590	peptidase
VN11_RS15730	COG0697	spore germination
VN11_RS15740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VN11_RS15745	COG2311	Membrane
VN11_RS15750	COG1047	Peptidyl-prolyl cis-trans
VN11_RS15755	COG0791	NLP P60 protein
VN11_RS15760	COG0791	NLP P60 protein
VN11_RS15765	COG1301	dicarboxylic acid transport
VN11_RS15785	COG1722	exodeoxyribonuclease VII activity
VN11_RS15790	COG0142	geranyltranstransferase activity
VN11_RS15800	COG0312	modulator of DNA gyrase
VN11_RS15805	COG3028	Belongs to the UPF0307 family
VN11_RS15810	COG0312	modulator of DNA gyrase
VN11_RS15830	COG2968	Membrane
VN11_RS15840	COG4771	TonB-dependent receptor
VN11_RS15850	COG0657	acetylesterase activity
VN11_RS15850	COG2755	lipolytic protein G-D-S-L family
VN11_RS15860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VN11_RS15870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VN11_RS15885	COG0495	leucyl-tRNA aminoacylation
VN11_RS15900	COG3118	belongs to the thioredoxin family
VN11_RS15910	COG2203	Gaf domain
VN11_RS15910	COG5001	Diguanylate cyclase
VN11_RS15910	COG3706	GGDEF domain
VN11_RS15910	COG4251	negative regulation of phosphorylation
VN11_RS15935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VN11_RS15945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VN11_RS15950	COG0346	lactoylglutathione lyase activity
VN11_RS15960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VN11_RS15960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VN11_RS15970	COG2878	Part of a membrane complex involved in electron transport
VN11_RS15975	COG0251	oxidation-reduction process
VN11_RS15980	COG0392	lysyltransferase activity
VN11_RS15980	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
VN11_RS16010	COG2824	Alkylphosphonate utilization operon protein PhnA
VN11_RS16015	COG1077	Cell shape determining protein MreB Mrl
VN11_RS16040	COG1595	DNA-templated transcription, initiation
VN11_RS16055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VN11_RS16060	COG3122	Protein conserved in bacteria
VN11_RS16065	COG1451	nucleotide metabolic process
VN11_RS16075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VN11_RS16095	COG0183	Belongs to the thiolase family
VN11_RS16110	COG1960	acyl-CoA dehydrogenase activity
VN11_RS16120	COG1793	dna ligase
VN11_RS16125	COG1201	RNA secondary structure unwinding
VN11_RS16140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VN11_RS16145	COG1278	Cold shock
VN11_RS16150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VN11_RS16155	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
VN11_RS16160	COG1472	Belongs to the glycosyl hydrolase 3 family
VN11_RS16165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
VN11_RS16170	COG2954	triphosphatase activity
VN11_RS16175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VN11_RS16180	COG0745	RESPONSE REGULATOR receiver
VN11_RS16185	COG1381	Involved in DNA repair and RecF pathway recombination
VN11_RS16190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VN11_RS16205	COG0681	Belongs to the peptidase S26 family
VN11_RS16210	COG0481	GTPase activity
VN11_RS16215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VN11_RS16235	COG1741	Belongs to the pirin family
VN11_RS16240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VN11_RS16250	COG1741	Belongs to the pirin family
VN11_RS16255	COG1966	Carbon starvation protein
VN11_RS16260	COG2879	small protein
VN11_RS16280	COG2205	protein histidine kinase activity
VN11_RS16320	COG2814	Major facilitator Superfamily
VN11_RS16325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VN11_RS16325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VN11_RS16335	COG1113	amino acid transport
VN11_RS16340	COG1917	Cupin 2, conserved barrel domain protein
VN11_RS16340	COG2207	Transcriptional regulator
VN11_RS16355	COG1376	ErfK ybiS ycfS ynhG family protein
VN11_RS16375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VN11_RS16385	COG0330	HflC and HflK could
VN11_RS16390	COG0330	HflC and HflK could
VN11_RS16395	COG0604	alcohol dehydrogenase
VN11_RS16410	COG0678	peroxiredoxin activity
VN11_RS16420	COG4953	penicillin-binding protein 1C
VN11_RS16425	COG2373	Large extracellular alpha-helical protein
VN11_RS16430	COG2079	MmgE PrpD family protein
VN11_RS16435	COG2828	Protein conserved in bacteria
VN11_RS16470	COG0259	pyridoxamine-phosphate oxidase activity
VN11_RS16485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VN11_RS16505	COG0477	Major facilitator Superfamily
VN11_RS16525	COG3038	cytochrome b561
VN11_RS16540	COG1760	l-serine dehydratase
VN11_RS16545	COG2267	carboxylic ester hydrolase activity
VN11_RS16550	COG0460	homoserine dehydrogenase
VN11_RS16550	COG0527	aspartate kinase activity
VN11_RS16555	COG0626	cystathionine gamma-synthase activity
VN11_RS16560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VN11_RS16565	COG0739	heme binding
VN11_RS16570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VN11_RS16575	COG1272	protein, Hemolysin III
VN11_RS16590	COG0463	Glycosyl transferase, family 2
VN11_RS16595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VN11_RS16600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VN11_RS16610	COG4206	TonB-dependent receptor
VN11_RS16615	COG1309	transcriptional regulator
VN11_RS16655	COG0509	glycine decarboxylation via glycine cleavage system
VN11_RS16660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VN11_RS16670	COG0330	HflC and HflK could
VN11_RS16680	COG1742	UPF0060 membrane protein
VN11_RS16685	COG3956	TIGRFAM MazG family protein
VN11_RS16690	COG1218	3'(2'),5'-bisphosphate nucleotidase
VN11_RS16695	COG0494	nUDIX hydrolase
VN11_RS16705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VN11_RS16720	COG0643	Histidine kinase
VN11_RS16720	COG0784	Response regulator, receiver
VN11_RS16720	COG2198	Histidine kinase
VN11_RS16725	COG0840	transmembrane signaling receptor activity
VN11_RS16730	COG0835	chemotaxis
VN11_RS16745	COG0189	ligase activity
VN11_RS16760	COG1199	ATP-dependent helicase activity
VN11_RS16770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VN11_RS16775	COG1215	transferase activity, transferring glycosyl groups
VN11_RS16790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VN11_RS16800	COG1643	Atp-dependent helicase
VN11_RS16805	COG0783	Belongs to the Dps family
VN11_RS16810	COG0514	ATP-dependent DNA helicase (RecQ)
VN11_RS16820	COG2132	Multicopper oxidase
VN11_RS16885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VN11_RS16890	COG0602	queuosine metabolic process
VN11_RS16900	COG2885	chlorophyll binding
VN11_RS16905	COG0823	Involved in the tonB-independent uptake of proteins
VN11_RS16920	COG0811	peptide transport
VN11_RS16925	COG0824	Thioesterase
VN11_RS16930	COG2255	four-way junction helicase activity
VN11_RS16940	COG0632	four-way junction helicase activity
VN11_RS16945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VN11_RS16950	COG0217	transcriptional regulatory protein
VN11_RS16970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VN11_RS17000	COG0488	(ABC) transporter
VN11_RS17010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VN11_RS17010	COG4651	solute:proton antiporter activity
VN11_RS17020	COG0745	RESPONSE REGULATOR receiver
VN11_RS17025	COG2205	protein histidine kinase activity
VN11_RS17035	COG0542	response to heat
VN11_RS17040	COG1595	DNA-templated transcription, initiation
VN11_RS17045	COG3712	iron ion homeostasis
VN11_RS17050	COG4771	TonB-dependent receptor
VN11_RS17055	COG1858	cytochrome C peroxidase
VN11_RS17080	COG0028	Belongs to the TPP enzyme family
VN11_RS17105	COG3387	PFAM Glycoside hydrolase 15-related
VN11_RS17110	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
VN11_RS17120	COG3011	Protein conserved in bacteria
VN11_RS17135	COG0564	pseudouridine synthase activity
VN11_RS17140	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VN11_RS17145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VN11_RS17145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VN11_RS17155	COG0045	succinate-CoA ligase (ADP-forming) activity
VN11_RS17180	COG4969	Belongs to the N-Me-Phe pilin family
VN11_RS17190	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VN11_RS17265	COG0745	RESPONSE REGULATOR receiver
VN11_RS17280	COG0189	ligase activity
VN11_RS17300	COG3240	lipase activity
VN11_RS17300	COG4625	pathogenesis
VN11_RS17310	COG2022	thiamine diphosphate biosynthetic process
VN11_RS17315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VN11_RS17320	COG0471	metal ion transport
VN11_RS17320	COG3273	potassium ion transport
VN11_RS17340	COG1970	mechanosensitive ion channel activity
VN11_RS17350	COG1115	amino acid carrier protein
VN11_RS17360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VN11_RS17365	COG1115	amino acid carrier protein
VN11_RS17370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VN11_RS17375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VN11_RS17380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS17405	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VN11_RS17415	COG3588	fructose-bisphosphate aldolase
VN11_RS17420	COG0469	pyruvate kinase activity
VN11_RS17430	COG0126	phosphoglycerate kinase activity
VN11_RS17450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VN11_RS17455	COG3047	cAMP biosynthetic process
VN11_RS17505	COG3093	addiction module antidote protein HigA
VN11_RS17510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VN11_RS17515	COG1301	dicarboxylic acid transport
VN11_RS17545	COG0714	Associated with various cellular activities
VN11_RS17575	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VN11_RS17590	COG5295	Hep Hag repeat protein
VN11_RS17630	COG0254	rRNA binding
VN11_RS17640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VN11_RS17650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VN11_RS17655	COG1758	RNA polymerase activity
VN11_RS17665	COG0243	molybdopterin cofactor binding
VN11_RS17665	COG3383	formate dehydrogenase (NAD+) activity
VN11_RS17670	COG3383	formate dehydrogenase (NAD+) activity
VN11_RS17670	COG0243	molybdopterin cofactor binding
VN11_RS17675	COG0437	4 iron, 4 sulfur cluster binding
VN11_RS17680	COG2864	formate dehydrogenase
VN11_RS17690	COG1921	L-seryl-tRNASec selenium transferase activity
VN11_RS17695	COG3276	selenocysteine insertion sequence binding
VN11_RS17705	COG0709	Synthesizes selenophosphate from selenide and ATP
VN11_RS17710	COG1561	YicC-like family, N-terminal region
VN11_RS17715	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VN11_RS17720	COG0346	lactoylglutathione lyase activity
VN11_RS17730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VN11_RS17745	COG0006	proline dipeptidase activity
VN11_RS17750	COG0006	proline dipeptidase activity
VN11_RS17755	COG3079	Belongs to the UPF0149 family
VN11_RS17770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VN11_RS17780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VN11_RS17790	COG2912	Transglutaminase-like superfamily
VN11_RS17800	COG0352	thiamine-phosphate diphosphorylase activity
VN11_RS17805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VN11_RS17810	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VN11_RS17815	COG1011	Hydrolase
VN11_RS17820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VN11_RS17825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VN11_RS17840	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS17860	COG0671	phosphoesterase, PA-phosphatase related
VN11_RS17870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VN11_RS17875	COG0563	adenylate kinase activity
VN11_RS17895	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
VN11_RS17905	COG0848	biopolymer transport protein
VN11_RS17915	COG2832	Protein of unknown function (DUF454)
VN11_RS17955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VN11_RS17980	COG0745	RESPONSE REGULATOR receiver
VN11_RS17990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VN11_RS17995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VN11_RS18000	COG0405	Gamma-glutamyltransferase
VN11_RS18005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VN11_RS18025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VN11_RS18030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VN11_RS18045	COG0473	3-isopropylmalate dehydrogenase activity
VN11_RS18065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VN11_RS18070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS18085	COG1538	Outer membrane efflux protein
VN11_RS18095	COG1519	Transferase
VN11_RS18100	COG1560	Kdo2-lipid A biosynthetic process
VN11_RS18130	COG1301	dicarboxylic acid transport
VN11_RS18140	COG4191	Histidine kinase
VN11_RS18155	COG0642	Histidine kinase
VN11_RS18170	COG2851	Citrate transporter
VN11_RS18175	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS18200	COG1162	GTPase activity
VN11_RS18205	COG0436	Aminotransferase
VN11_RS18215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VN11_RS18230	COG1228	amidohydrolase
VN11_RS18235	COG0804	urea catabolic process
VN11_RS18245	COG1307	EDD domain protein, DegV family
VN11_RS18270	COG0583	DNA-binding transcription factor activity
VN11_RS18285	COG5001	Diguanylate cyclase
VN11_RS18285	COG4251	negative regulation of phosphorylation
VN11_RS18285	COG3706	GGDEF domain
VN11_RS18285	COG2203	Gaf domain
VN11_RS18290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VN11_RS18295	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VN11_RS18315	COG1902	pentaerythritol trinitrate reductase activity
VN11_RS18335	COG0583	DNA-binding transcription factor activity
VN11_RS18340	COG1064	alcohol dehydrogenase
VN11_RS18365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VN11_RS18370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VN11_RS18380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VN11_RS18385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VN11_RS18400	COG1522	sequence-specific DNA binding
VN11_RS18415	COG4773	Receptor
VN11_RS18420	COG4206	TonB-dependent receptor
VN11_RS18445	COG0617	tRNA 3'-terminal CCA addition
VN11_RS18515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VN11_RS18520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VN11_RS18525	COG1609	Transcriptional regulator
VN11_RS18535	COG0837	glucose binding
VN11_RS18545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
VN11_RS18565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VN11_RS18575	COG4191	Histidine kinase
VN11_RS18580	COG0784	Response regulator, receiver
VN11_RS18585	COG4251	negative regulation of phosphorylation
VN11_RS18590	COG2823	Periplasmic or secreted lipoprotein
VN11_RS18595	COG0673	inositol 2-dehydrogenase activity
VN11_RS18600	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
VN11_RS18620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VN11_RS18625	COG0321	lipoyl(octanoyl) transferase activity
VN11_RS18630	COG2921	Belongs to the UPF0250 family
VN11_RS18645	COG1686	Belongs to the peptidase S11 family
VN11_RS18650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VN11_RS18655	COG2951	lytic endotransglycosylase activity
VN11_RS18665	COG0772	Belongs to the SEDS family
VN11_RS18680	COG1792	Involved in formation and maintenance of cell shape
VN11_RS18685	COG1077	Cell shape determining protein MreB Mrl
VN11_RS18690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VN11_RS18705	COG0308	aminopeptidase N
VN11_RS18710	COG2226	methyltransferase
VN11_RS18740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VN11_RS18745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS18755	COG0673	inositol 2-dehydrogenase activity
VN11_RS18765	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VN11_RS18785	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VN11_RS18795	COG2832	Protein of unknown function (DUF454)
VN11_RS18805	COG0436	Aminotransferase
VN11_RS18810	COG1505	serine-type exopeptidase activity
VN11_RS18845	COG0697	spore germination
VN11_RS18850	COG1666	GTP binding
VN11_RS18865	COG0339	signal peptide processing
VN11_RS18875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VN11_RS18900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VN11_RS18910	COG1136	(ABC) transporter
VN11_RS18920	COG0577	efflux transmembrane transporter activity
VN11_RS18935	COG4191	Histidine kinase
VN11_RS18945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VN11_RS18955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VN11_RS18960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VN11_RS18965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VN11_RS18970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VN11_RS18975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VN11_RS18980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VN11_RS18990	COG0356	it plays a direct role in the translocation of protons across the membrane
VN11_RS19005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VN11_RS19010	COG0508	dehydrogenase complex catalyzes the overall conversion of
VN11_RS19030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VN11_RS19055	COG0181	hydroxymethylbilane synthase activity
VN11_RS19065	COG2972	Histidine kinase
VN11_RS19065	COG0745	RESPONSE REGULATOR receiver
VN11_RS19080	COG4771	TonB-dependent receptor
VN11_RS19110	COG0477	Major facilitator Superfamily
VN11_RS19145	COG0625	glutathione transferase activity
VN11_RS19160	COG2259	Doxx family
VN11_RS19175	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VN11_RS19190	COG3209	COG3209 Rhs family protein
VN11_RS19200	COG3209	COG3209 Rhs family protein
VN11_RS19215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VN11_RS19220	COG1490	D-aminoacyl-tRNA deacylase activity
VN11_RS19265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VN11_RS19265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VN11_RS19270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VN11_RS19275	COG0242	peptide deformylase activity
VN11_RS19285	COG0758	DNA mediated transformation
VN11_RS19290	COG2922	Belongs to the Smg family
VN11_RS19300	COG1714	RDD family
VN11_RS19305	COG1754	DNA topoisomerase type I activity
VN11_RS19305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VN11_RS19310	COG0009	L-threonylcarbamoyladenylate synthase
VN11_RS19325	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS19335	COG0616	signal peptide processing
VN11_RS19340	COG0534	Mate efflux family protein
VN11_RS19355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VN11_RS19360	COG0625	glutathione transferase activity
VN11_RS19370	COG1252	NADH dehydrogenase
VN11_RS19385	COG2860	membrane
VN11_RS19390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VN11_RS19405	COG1846	Transcriptional regulator
VN11_RS19430	COG0459	protein refolding
VN11_RS19435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VN11_RS19440	COG2356	endonuclease I
VN11_RS19445	COG1324	tolerance protein
VN11_RS19455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VN11_RS19465	COG0840	transmembrane signaling receptor activity
VN11_RS19485	COG4585	Histidine kinase
VN11_RS19510	COG3454	Phosphonate metabolism
VN11_RS19515	COG2188	Transcriptional regulator
VN11_RS19520	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VN11_RS19520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VN11_RS19535	COG0583	DNA-binding transcription factor activity
VN11_RS19545	COG1785	Belongs to the alkaline phosphatase family
VN11_RS19550	COG1686	Belongs to the peptidase S11 family
VN11_RS19560	COG2249	NAD(P)H dehydrogenase (quinone) activity
VN11_RS19570	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VN11_RS19580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VN11_RS19590	COG0511	ligase activity, forming carbon-carbon bonds
VN11_RS19595	COG0439	Biotin carboxylase
VN11_RS19610	COG2264	protein methyltransferase activity
VN11_RS19620	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VN11_RS19625	COG4589	Belongs to the CDS family
VN11_RS19640	COG2453	phosphatase
VN11_RS19640	COG0671	phosphoesterase, PA-phosphatase related
VN11_RS19645	COG2267	carboxylic ester hydrolase activity
VN11_RS19650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VN11_RS19655	COG0138	bifunctional purine biosynthesis protein purh
VN11_RS19665	COG0151	Belongs to the GarS family
VN11_RS19675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VN11_RS19680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VN11_RS19685	COG2201	protein-glutamate methylesterase activity
VN11_RS19690	COG2177	Part of the ABC transporter FtsEX involved in
VN11_RS19695	COG2884	Cell division ATP-binding protein ftsE
VN11_RS19705	COG3118	belongs to the thioredoxin family
VN11_RS19710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VN11_RS19715	COG1472	Belongs to the glycosyl hydrolase 3 family
VN11_RS19720	COG1609	Transcriptional regulator
VN11_RS19740	COG3706	GGDEF domain
VN11_RS19750	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
VN11_RS19790	COG1652	LysM domain
VN11_RS19795	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VN11_RS19795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VN11_RS19800	COG1473	amidohydrolase
VN11_RS19805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS19810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VN11_RS19815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VN11_RS19820	COG1289	transmembrane transporter activity
VN11_RS19825	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS19830	COG2814	Major facilitator Superfamily
VN11_RS19860	COG0316	Belongs to the HesB IscA family
VN11_RS19900	COG1051	belongs to the nudix hydrolase family
VN11_RS19915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VN11_RS19920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VN11_RS19925	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
VN11_RS19935	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VN11_RS19940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VN11_RS19945	COG0730	response to heat
VN11_RS19955	COG0134	indole-3-glycerol-phosphate synthase activity
VN11_RS19960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VN11_RS19980	COG1597	lipid kinase activity
VN11_RS19995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VN11_RS20000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VN11_RS20010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VN11_RS20010	COG2111	Na H antiporter
VN11_RS20015	COG1006	Multisubunit Na H antiporter MnhC subunit
VN11_RS20020	COG0651	ATP synthesis coupled electron transport
VN11_RS20025	COG1863	multisubunit Na H antiporter MnhE subunit
VN11_RS20030	COG2212	antiporter activity
VN11_RS20035	COG1320	monovalent cation:proton antiporter activity
VN11_RS20055	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VN11_RS20080	COG3104	oligopeptide transport
VN11_RS20085	COG3483	tryptophan 2,3-dioxygenase activity
VN11_RS20115	COG2378	regulation of single-species biofilm formation
VN11_RS20120	COG0702	epimerase
VN11_RS20130	COG2354	Protein conserved in bacteria
VN11_RS20135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VN11_RS20140	COG1368	sulfuric ester hydrolase activity
VN11_RS20145	COG3264	Mechanosensitive ion channel
VN11_RS20145	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VN11_RS20160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VN11_RS20160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VN11_RS20175	COG3212	peptidase
VN11_RS20195	COG1166	arginine decarboxylase activity
VN11_RS20200	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VN11_RS20220	COG2960	long-chain fatty acid transporting porin activity
VN11_RS20265	COG0606	chelatase, subunit chli
VN11_RS20275	COG0561	phosphatase activity
VN11_RS20280	COG3932	Exopolysaccharide synthesis, ExoD
VN11_RS20305	COG1999	signal sequence binding
VN11_RS20310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VN11_RS20315	COG1845	cytochrome c oxidase, subunit III
VN11_RS20325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VN11_RS20330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VN11_RS20345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VN11_RS20350	COG1104	cysteine desulfurase activity
VN11_RS20380	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
VN11_RS20400	COG2031	fatty acid transporter
VN11_RS20415	COG2207	Transcriptional regulator
VN11_RS20415	COG4753	response regulator
VN11_RS20420	COG0750	zinc metalloprotease
VN11_RS20425	COG0673	inositol 2-dehydrogenase activity
VN11_RS20435	COG1501	Belongs to the glycosyl hydrolase 31 family
VN11_RS20440	COG2222	sugar isomerase
VN11_RS20445	COG1940	carbohydrate kinase activity
VN11_RS20455	COG1349	DNA-binding transcription factor activity
VN11_RS20460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VN11_RS20465	COG2814	Major facilitator Superfamily
VN11_RS20490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VN11_RS20490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VN11_RS20525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VN11_RS20530	COG0156	8-amino-7-oxononanoate synthase activity
VN11_RS20535	COG2267	carboxylic ester hydrolase activity
VN11_RS20540	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS20555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VN11_RS20575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VN11_RS20580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VN11_RS20585	COG2205	protein histidine kinase activity
VN11_RS20590	COG0745	RESPONSE REGULATOR receiver
VN11_RS20595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VN11_RS20620	COG0714	Associated with various cellular activities
VN11_RS20630	COG0754	glutathionylspermidine amidase activity
VN11_RS20640	COG0129	dihydroxy-acid dehydratase activity
VN11_RS20645	COG2311	Membrane
VN11_RS20650	COG1199	ATP-dependent helicase activity
VN11_RS20660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VN11_RS20680	COG3781	membrane
VN11_RS20710	COG0625	glutathione transferase activity
VN11_RS20730	COG2207	Transcriptional regulator
VN11_RS20760	COG4555	ABC transporter
VN11_RS20875	COG4771	TonB-dependent receptor
VN11_RS20885	COG1028	Short-chain dehydrogenase reductase Sdr
VN11_RS20890	COG0583	DNA-binding transcription factor activity
VN11_RS20900	COG2801	Transposase and inactivated derivatives
VN11_RS20905	COG2963	transposase activity
VN11_RS20925	COG0633	Ferredoxin
VN11_RS20925	COG0543	2 iron, 2 sulfur cluster binding
VN11_RS20930	COG1131	(ABC) transporter
VN11_RS20935	COG0842	Transport permease protein
VN11_RS20940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VN11_RS20950	COG0084	hydrolase, TatD family'
VN11_RS20955	COG1643	Atp-dependent helicase
VN11_RS20965	COG1187	pseudouridine synthase activity
VN11_RS20980	COG0667	Aldo Keto reductase
VN11_RS20995	COG1690	Belongs to the RtcB family
VN11_RS21015	COG0583	DNA-binding transcription factor activity
VN11_RS21020	COG2814	Major facilitator Superfamily
VN11_RS21030	COG2267	carboxylic ester hydrolase activity
VN11_RS21035	COG0393	Putative heavy-metal-binding
VN11_RS21040	COG1042	CoA-binding domain protein
VN11_RS21040	COG0045	succinate-CoA ligase (ADP-forming) activity
VN11_RS21040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VN11_RS21045	COG2239	Acts as a magnesium transporter
VN11_RS21060	COG3100	YcgL domain-containing protein
VN11_RS21065	COG1294	oxidase, subunit
VN11_RS21070	COG1271	oxidase subunit
VN11_RS21080	COG1595	DNA-templated transcription, initiation
VN11_RS21095	COG0494	nUDIX hydrolase
VN11_RS21115	COG0408	coproporphyrinogen oxidase activity
VN11_RS21125	COG2323	membrane
VN11_RS21150	COG0589	response to stress
VN11_RS21160	COG0210	DNA helicase
VN11_RS21170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VN11_RS21175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VN11_RS21180	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VN11_RS21195	COG0251	oxidation-reduction process
VN11_RS21230	COG0463	Glycosyl transferase, family 2
VN11_RS21245	COG1475	DNA binding
VN11_RS21250	COG1192	Involved in chromosome partitioning
VN11_RS21255	COG0357	Ribosomal RNA small subunit methyltransferase G
VN11_RS21260	COG2091	lysine biosynthetic process via aminoadipic acid
VN11_RS21310	COG1971	Probably functions as a manganese efflux pump
VN11_RS21315	COG0784	Response regulator, receiver
VN11_RS21315	COG2205	protein histidine kinase activity
VN11_RS21330	COG0729	surface antigen
VN11_RS21340	COG0752	glycyl-tRNA synthetase alpha subunit
VN11_RS21345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VN11_RS21350	COG0519	Catalyzes the synthesis of GMP from XMP
VN11_RS21350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VN11_RS21360	COG0805	protein transport
VN11_RS21370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VN11_RS21380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VN11_RS21390	COG0840	transmembrane signaling receptor activity
VN11_RS21445	COG3135	benzoate transporter
VN11_RS21455	COG0676	glucose-6-phosphate 1-epimerase activity
VN11_RS21460	COG2951	lytic endotransglycosylase activity
VN11_RS21465	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
VN11_RS21470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VN11_RS21475	COG3706	GGDEF domain
VN11_RS21505	COG0302	gtp cyclohydrolase
VN11_RS21520	COG1566	PFAM secretion protein HlyD family protein
VN11_RS21530	COG1289	transmembrane transporter activity
VN11_RS21545	COG1074	ATP-dependent DNA helicase activity
VN11_RS21550	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VN11_RS21555	COG1127	ABC transporter
VN11_RS21560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VN11_RS21565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VN11_RS21580	COG2853	Lipoprotein
VN11_RS21585	COG0386	Belongs to the glutathione peroxidase family
VN11_RS21595	COG1322	Protein conserved in bacteria
VN11_RS21610	COG0583	DNA-binding transcription factor activity
VN11_RS21620	COG0531	amino acid
VN11_RS21630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VN11_RS21635	COG0861	Integral membrane protein TerC family
VN11_RS21645	COG0584	glycerophosphoryl diester phosphodiesterase
VN11_RS21660	COG0706	membrane insertase activity
VN11_RS21665	COG0594	ribonuclease P activity
VN11_RS21670	COG0230	Belongs to the bacterial ribosomal protein bL34 family