locus-tag	class	description
G6Z48_RS00005	COG0442	prolyl-tRNA aminoacylation
G6Z48_RS00015	COG1183	phosphatidylcholine synthase activity
G6Z48_RS00025	COG0456	acetyltransferase
G6Z48_RS00035	COG0525	valine-tRNA ligase activity
G6Z48_RS00045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G6Z48_RS00055	COG0795	lipopolysaccharide-transporting ATPase activity
G6Z48_RS00070	COG4974	Belongs to the 'phage' integrase family
G6Z48_RS00075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G6Z48_RS00085	COG0047	phosphoribosylformylglycinamidine synthase activity
G6Z48_RS00085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G6Z48_RS00090	COG5295	Hep Hag repeat protein
G6Z48_RS00095	COG1404	Belongs to the peptidase S8 family
G6Z48_RS00100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G6Z48_RS00105	COG1459	type II secretion system
G6Z48_RS00110	COG2165	general secretion pathway protein
G6Z48_RS00115	COG4970	Tfp pilus assembly protein FimT
G6Z48_RS00120	COG2165	general secretion pathway protein
G6Z48_RS00125	COG4795	General secretion pathway protein
G6Z48_RS00130	COG3156	type II secretion system protein K
G6Z48_RS00135	COG3166	PFAM Fimbrial assembly family protein
G6Z48_RS00150	COG1450	Type ii and iii secretion system protein
G6Z48_RS00175	COG3539	Fimbrial protein
G6Z48_RS00195	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G6Z48_RS00205	COG1215	transferase activity, transferring glycosyl groups
G6Z48_RS00220	COG2252	PERMEase
G6Z48_RS00225	COG0488	(ABC) transporter
G6Z48_RS00235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G6Z48_RS00255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G6Z48_RS00260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G6Z48_RS00260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G6Z48_RS00295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G6Z48_RS00300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6Z48_RS00310	COG3121	Chaperone
G6Z48_RS00325	COG3188	usher protein
G6Z48_RS00335	COG2755	lipolytic protein G-D-S-L family
G6Z48_RS00335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G6Z48_RS00340	COG0277	FAD linked oxidase domain protein
G6Z48_RS00345	COG1988	membrane-bound metal-dependent
G6Z48_RS00380	COG2001	Belongs to the MraZ family
G6Z48_RS00385	COG0275	rRNA processing
G6Z48_RS00390	COG3116	cell division
G6Z48_RS00405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G6Z48_RS00425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G6Z48_RS00430	COG1181	Belongs to the D-alanine--D-alanine ligase family
G6Z48_RS00435	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G6Z48_RS00445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G6Z48_RS00450	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G6Z48_RS00460	COG0739	heme binding
G6Z48_RS00465	COG0653	protein targeting
G6Z48_RS00470	COG0494	nUDIX hydrolase
G6Z48_RS00480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G6Z48_RS00490	COG3275	phosphorelay sensor kinase activity
G6Z48_RS00495	COG3279	Response regulator of the LytR AlgR family
G6Z48_RS00515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G6Z48_RS00520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G6Z48_RS00535	COG1607	acyl-coa hydrolase
G6Z48_RS00540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G6Z48_RS00570	COG4106	trans-aconitate 2-methyltransferase activity
G6Z48_RS00575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G6Z48_RS00595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6Z48_RS00600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G6Z48_RS00605	COG0667	Aldo Keto reductase
G6Z48_RS00615	COG4771	TonB-dependent receptor
G6Z48_RS00635	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G6Z48_RS00640	COG4181	ATPase activity
G6Z48_RS00655	COG0642	Histidine kinase
G6Z48_RS00665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G6Z48_RS00670	COG0861	Integral membrane protein TerC family
G6Z48_RS00675	COG2814	Major facilitator Superfamily
G6Z48_RS00680	COG1704	LemA family
G6Z48_RS00695	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G6Z48_RS00700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G6Z48_RS00710	COG3738	Protein conserved in bacteria
G6Z48_RS00715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G6Z48_RS00720	COG2967	ApaG domain
G6Z48_RS00725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G6Z48_RS00730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G6Z48_RS00735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6Z48_RS00740	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G6Z48_RS00750	COG2096	Adenosyltransferase
G6Z48_RS00760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6Z48_RS00765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6Z48_RS00770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G6Z48_RS00775	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
G6Z48_RS00795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6Z48_RS00805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6Z48_RS00820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6Z48_RS00825	COG0583	DNA-binding transcription factor activity
G6Z48_RS00830	COG3634	alkyl hydroperoxide reductase activity
G6Z48_RS00870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G6Z48_RS00870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G6Z48_RS00885	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G6Z48_RS00910	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
G6Z48_RS00925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G6Z48_RS00930	COG1404	Belongs to the peptidase S8 family
G6Z48_RS00950	COG1295	ribonuclease BN
G6Z48_RS00955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6Z48_RS00970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G6Z48_RS00975	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G6Z48_RS00990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G6Z48_RS01000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G6Z48_RS01005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G6Z48_RS01010	COG0193	aminoacyl-tRNA hydrolase activity
G6Z48_RS01015	COG0012	GTP binding
G6Z48_RS01025	COG2197	response regulator
G6Z48_RS01030	COG0784	Response regulator, receiver
G6Z48_RS01030	COG2205	protein histidine kinase activity
G6Z48_RS01035	COG2203	Gaf domain
G6Z48_RS01035	COG2200	EAL domain
G6Z48_RS01035	COG2199	diguanylate cyclase activity
G6Z48_RS01040	COG2205	protein histidine kinase activity
G6Z48_RS01040	COG0784	Response regulator, receiver
G6Z48_RS01045	COG4206	TonB-dependent receptor
G6Z48_RS01050	COG4242	Belongs to the peptidase S51 family
G6Z48_RS01075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G6Z48_RS01090	COG0250	Participates in transcription elongation, termination and antitermination
G6Z48_RS01095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G6Z48_RS01100	COG0081	regulation of translation
G6Z48_RS01105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G6Z48_RS01110	COG0222	ribosome binding
G6Z48_RS01115	COG0085	RNA polymerase activity
G6Z48_RS01120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G6Z48_RS01125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G6Z48_RS01130	COG0049	tRNA binding
G6Z48_RS01135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G6Z48_RS01140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G6Z48_RS01145	COG0051	transcription antitermination factor activity, RNA binding
G6Z48_RS01150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G6Z48_RS01155	COG0088	Forms part of the polypeptide exit tunnel
G6Z48_RS01160	COG0089	rRNA binding
G6Z48_RS01165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G6Z48_RS01170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G6Z48_RS01175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G6Z48_RS01180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G6Z48_RS01185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G6Z48_RS01190	COG0255	Belongs to the universal ribosomal protein uL29 family
G6Z48_RS01195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G6Z48_RS01200	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G6Z48_RS01205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G6Z48_RS01210	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G6Z48_RS01215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G6Z48_RS01220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G6Z48_RS01225	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G6Z48_RS01230	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G6Z48_RS01235	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G6Z48_RS01240	COG1841	ribosomal large subunit assembly
G6Z48_RS01245	COG0200	Binds to the 23S rRNA
G6Z48_RS01250	COG0201	protein transport
G6Z48_RS01255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G6Z48_RS01260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G6Z48_RS01265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G6Z48_RS01270	COG0202	RNA polymerase activity
G6Z48_RS01275	COG0203	ribosomal protein L17
G6Z48_RS01290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G6Z48_RS01300	COG0154	amidase activity
G6Z48_RS01315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G6Z48_RS01320	COG0039	L-malate dehydrogenase activity
G6Z48_RS01325	COG0564	pseudouridine synthase activity
G6Z48_RS01330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6Z48_RS01345	COG0625	glutathione transferase activity
G6Z48_RS01355	COG0446	pyridine nucleotide-disulphide oxidoreductase
G6Z48_RS01355	COG1902	pentaerythritol trinitrate reductase activity
G6Z48_RS01360	COG2364	Membrane
G6Z48_RS01365	COG0604	alcohol dehydrogenase
G6Z48_RS01380	COG1187	pseudouridine synthase activity
G6Z48_RS01400	COG1063	alcohol dehydrogenase
G6Z48_RS01410	COG0406	alpha-ribazole phosphatase activity
G6Z48_RS01415	COG0285	dihydrofolate synthase activity
G6Z48_RS01435	COG2833	Protein of unknown function (DUF455)
G6Z48_RS01445	COG3291	Pkd domain containing protein
G6Z48_RS01450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G6Z48_RS01460	COG0438	transferase activity, transferring glycosyl groups
G6Z48_RS01475	COG0248	Ppx GppA phosphatase
G6Z48_RS01480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G6Z48_RS01495	COG4783	chaperone-mediated protein folding
G6Z48_RS01510	COG0473	3-isopropylmalate dehydrogenase activity
G6Z48_RS01595	COG0592	DNA-directed DNA polymerase activity
G6Z48_RS01610	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS01625	COG3772	lysozyme
G6Z48_RS01770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G6Z48_RS01770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G6Z48_RS01855	COG0544	peptidyl-prolyl cis-trans isomerase activity
G6Z48_RS01860	COG0740	serine-type endopeptidase activity
G6Z48_RS01865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G6Z48_RS01905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6Z48_RS01910	COG3942	CHAP domain
G6Z48_RS01910	COG1388	LysM domain
G6Z48_RS01915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G6Z48_RS01925	COG0328	RNA-DNA hybrid ribonuclease activity
G6Z48_RS01930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G6Z48_RS01935	COG0631	protein serine/threonine phosphatase activity
G6Z48_RS01955	COG0859	PFAM glycosyl transferase family 9
G6Z48_RS01960	COG3642	lipopolysaccharide core region biosynthetic process
G6Z48_RS01965	COG1234	tRNA 3'-trailer cleavage
G6Z48_RS01980	COG2076	Multidrug Resistance protein
G6Z48_RS02020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G6Z48_RS02030	COG0537	adenosine 5'-monophosphoramidase activity
G6Z48_RS02050	COG0714	Associated with various cellular activities
G6Z48_RS02065	COG1399	metal-binding, possibly nucleic acid-binding protein
G6Z48_RS02070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G6Z48_RS02075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G6Z48_RS02085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G6Z48_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS02100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G6Z48_RS02105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G6Z48_RS02110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G6Z48_RS02115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G6Z48_RS02270	COG4774	siderophore transport
G6Z48_RS02280	COG2223	nitrite transmembrane transporter activity
G6Z48_RS02295	COG2226	methyltransferase
G6Z48_RS02305	COG0583	DNA-binding transcription factor activity
G6Z48_RS02310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z48_RS02315	COG0697	spore germination
G6Z48_RS02325	COG0477	Major facilitator Superfamily
G6Z48_RS02360	COG0583	DNA-binding transcription factor activity
G6Z48_RS02370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G6Z48_RS02385	COG0667	Aldo Keto reductase
G6Z48_RS02405	COG2818	Glycosylase
G6Z48_RS02410	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
G6Z48_RS02415	COG1678	Uncharacterized ACR, COG1678
G6Z48_RS02420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G6Z48_RS02425	COG0540	Belongs to the ATCase OTCase family
G6Z48_RS02445	COG2239	Acts as a magnesium transporter
G6Z48_RS02450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G6Z48_RS02465	COG1660	Displays ATPase and GTPase activities
G6Z48_RS02470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G6Z48_RS02475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G6Z48_RS02480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G6Z48_RS02490	COG1137	ATPase activity
G6Z48_RS02505	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G6Z48_RS02520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G6Z48_RS02540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G6Z48_RS02560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G6Z48_RS02570	COG0628	permease
G6Z48_RS02580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G6Z48_RS02590	COG2261	transglycosylase associated protein
G6Z48_RS02600	COG1555	photosystem II stabilization
G6Z48_RS02620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G6Z48_RS02625	COG1477	protein flavinylation
G6Z48_RS02645	COG4771	TonB-dependent receptor
G6Z48_RS02655	COG3128	pkhd-type hydroxylase
G6Z48_RS02665	COG4774	siderophore transport
G6Z48_RS02675	COG2146	nitrite reductase [NAD(P)H] activity
G6Z48_RS02690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G6Z48_RS02695	COG0719	Fe-S assembly protein
G6Z48_RS02700	COG0396	ATPase activity
G6Z48_RS02710	COG0719	Fe-S assembly protein
G6Z48_RS02715	COG1959	2 iron, 2 sulfur cluster binding
G6Z48_RS02725	COG0693	protein deglycase activity
G6Z48_RS02750	COG1764	response to oxidative stress
G6Z48_RS02755	COG0384	phenazine biosynthesis protein PhzF
G6Z48_RS02760	COG0384	phenazine biosynthesis protein PhzF
G6Z48_RS02765	COG0527	aspartate kinase activity
G6Z48_RS02775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G6Z48_RS02790	COG0142	geranyltranstransferase activity
G6Z48_RS02795	COG0366	Alpha amylase catalytic
G6Z48_RS02805	COG1082	Xylose isomerase domain protein TIM barrel
G6Z48_RS02815	COG2211	Major facilitator Superfamily
G6Z48_RS02815	COG2190	(PTS) system
G6Z48_RS02850	COG1131	(ABC) transporter
G6Z48_RS02860	COG0629	single-stranded DNA binding
G6Z48_RS02885	COG2010	Cytochrome c
G6Z48_RS02895	COG0673	inositol 2-dehydrogenase activity
G6Z48_RS02900	COG2211	Major facilitator Superfamily
G6Z48_RS02910	COG1609	Transcriptional regulator
G6Z48_RS02925	COG3706	GGDEF domain
G6Z48_RS02950	COG0640	Transcriptional regulator
G6Z48_RS02965	COG3655	Transcriptional regulator
G6Z48_RS02970	COG1253	flavin adenine dinucleotide binding
G6Z48_RS02975	COG1408	metallophosphoesterase
G6Z48_RS02980	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G6Z48_RS03000	COG2259	Doxx family
G6Z48_RS03015	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS03045	COG1802	Transcriptional regulator
G6Z48_RS03080	COG3052	prosthetic group binding
G6Z48_RS03095	COG0579	oxidoreductase
G6Z48_RS03120	COG3104	oligopeptide transport
G6Z48_RS03135	COG1297	OPT oligopeptide transporter protein
G6Z48_RS03140	COG1506	peptidase
G6Z48_RS03140	COG0823	Involved in the tonB-independent uptake of proteins
G6Z48_RS03155	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G6Z48_RS03160	COG2894	cell division
G6Z48_RS03175	COG4585	Histidine kinase
G6Z48_RS03180	COG2197	response regulator
G6Z48_RS03220	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G6Z48_RS03230	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G6Z48_RS03240	COG1595	DNA-templated transcription, initiation
G6Z48_RS03250	COG1946	Acyl-CoA thioesterase
G6Z48_RS03270	COG0824	Thioesterase
G6Z48_RS03275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G6Z48_RS03280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G6Z48_RS03285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G6Z48_RS03290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G6Z48_RS03295	COG0268	Binds directly to 16S ribosomal RNA
G6Z48_RS03300	COG0728	peptidoglycan biosynthetic process
G6Z48_RS03305	COG0196	riboflavin kinase activity
G6Z48_RS03310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G6Z48_RS03320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G6Z48_RS03345	COG4206	TonB-dependent receptor
G6Z48_RS03365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G6Z48_RS03405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G6Z48_RS03410	COG1845	cytochrome c oxidase, subunit III
G6Z48_RS03415	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G6Z48_RS03430	COG0326	Molecular chaperone. Has ATPase activity
G6Z48_RS03450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G6Z48_RS03465	COG0228	four-way junction DNA binding
G6Z48_RS03470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G6Z48_RS03475	COG0336	Belongs to the RNA methyltransferase TrmD family
G6Z48_RS03480	COG0335	large ribosomal subunit rRNA binding
G6Z48_RS03500	COG0534	Mate efflux family protein
G6Z48_RS03520	COG0753	catalase activity
G6Z48_RS03575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G6Z48_RS03675	COG1192	Involved in chromosome partitioning
G6Z48_RS03760	COG2831	hemolysin activation secretion protein
G6Z48_RS03835	COG0840	transmembrane signaling receptor activity
G6Z48_RS03855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS03875	COG0024	Methionine aminopeptidase
G6Z48_RS03925	COG1647	Serine aminopeptidase, S33
G6Z48_RS03955	COG2814	Major facilitator Superfamily
G6Z48_RS03960	COG3706	GGDEF domain
G6Z48_RS03985	COG0588	phosphoglycerate mutase activity
G6Z48_RS03990	COG3590	peptidase
G6Z48_RS03995	COG2801	Transposase and inactivated derivatives
G6Z48_RS03995	COG3415	Transposase
G6Z48_RS04005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G6Z48_RS04015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G6Z48_RS04020	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS04025	COG2205	protein histidine kinase activity
G6Z48_RS04030	COG4452	Inner membrane protein CreD
G6Z48_RS04045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6Z48_RS04050	COG0735	belongs to the Fur family
G6Z48_RS04090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G6Z48_RS04130	COG5001	Diguanylate cyclase
G6Z48_RS04130	COG5002	protein histidine kinase activity
G6Z48_RS04140	COG1187	pseudouridine synthase activity
G6Z48_RS04145	COG3706	GGDEF domain
G6Z48_RS04150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G6Z48_RS04175	COG1132	(ABC) transporter
G6Z48_RS04225	COG1695	Transcriptional regulator
G6Z48_RS04250	COG0825	malonyl-CoA metabolic process
G6Z48_RS04275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G6Z48_RS04285	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G6Z48_RS04290	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6Z48_RS04295	COG0750	zinc metalloprotease
G6Z48_RS04300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G6Z48_RS04305	COG0575	Belongs to the CDS family
G6Z48_RS04310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G6Z48_RS04315	COG0233	cytoplasmic translational termination
G6Z48_RS04320	COG0528	UMP kinase activity
G6Z48_RS04325	COG3706	GGDEF domain
G6Z48_RS04330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G6Z48_RS04335	COG0052	Belongs to the universal ribosomal protein uS2 family
G6Z48_RS04355	COG3188	usher protein
G6Z48_RS04375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G6Z48_RS04390	COG1393	Belongs to the ArsC family
G6Z48_RS04395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6Z48_RS04400	COG0367	asparagine synthase
G6Z48_RS04405	COG0475	glutathione-regulated potassium exporter activity
G6Z48_RS04440	COG1566	PFAM secretion protein HlyD family protein
G6Z48_RS04445	COG2814	Major facilitator Superfamily
G6Z48_RS04460	COG0583	DNA-binding transcription factor activity
G6Z48_RS04480	COG0557	exoribonuclease II activity
G6Z48_RS04490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6Z48_RS04495	COG1538	Outer membrane efflux protein
G6Z48_RS04500	COG1136	(ABC) transporter
G6Z48_RS04500	COG0577	efflux transmembrane transporter activity
G6Z48_RS04505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS04510	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS04520	COG3706	GGDEF domain
G6Z48_RS04525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G6Z48_RS04530	COG2259	Doxx family
G6Z48_RS04540	COG3220	belongs to the UPF0276 family
G6Z48_RS04550	COG0704	Plays a role in the regulation of phosphate uptake
G6Z48_RS04560	COG0581	inorganic phosphate transmembrane transporter activity
G6Z48_RS04565	COG0573	inorganic phosphate transmembrane transporter activity
G6Z48_RS04570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G6Z48_RS04575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G6Z48_RS04585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G6Z48_RS04595	COG1024	Enoyl-CoA hydratase
G6Z48_RS04605	COG0494	nUDIX hydrolase
G6Z48_RS04625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G6Z48_RS04625	COG0116	Belongs to the methyltransferase superfamily
G6Z48_RS04645	COG2733	membrane
G6Z48_RS04660	COG1012	belongs to the aldehyde dehydrogenase family
G6Z48_RS04670	COG0477	Major facilitator Superfamily
G6Z48_RS04675	COG2703	oxygen carrier activity
G6Z48_RS04695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z48_RS04700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G6Z48_RS04705	COG0174	glutamine synthetase
G6Z48_RS04715	COG2072	flavoprotein involved in K transport
G6Z48_RS04720	COG3842	ATPase activity
G6Z48_RS04725	COG1176	ABC-type spermidine putrescine transport system, permease component I
G6Z48_RS04730	COG1177	transmembrane transport
G6Z48_RS04735	COG1012	belongs to the aldehyde dehydrogenase family
G6Z48_RS04750	COG4535	Mg2 and Co2 transporter CorC
G6Z48_RS04770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G6Z48_RS04775	COG1702	phosphate starvation-inducible protein PhoH
G6Z48_RS04780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS04785	COG1131	(ABC) transporter
G6Z48_RS04790	COG0842	Transport permease protein
G6Z48_RS04795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G6Z48_RS04810	COG0741	lytic transglycosylase activity
G6Z48_RS04815	COG0723	plastoquinol--plastocyanin reductase activity
G6Z48_RS04820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G6Z48_RS04825	COG2857	Cytochrome c1
G6Z48_RS04830	COG0625	glutathione transferase activity
G6Z48_RS04835	COG2969	positive regulation of protein catabolic process
G6Z48_RS04870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6Z48_RS04880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G6Z48_RS04895	COG1611	Belongs to the LOG family
G6Z48_RS04940	COG0556	nucleotide-excision repair
G6Z48_RS04980	COG3713	MltA-interacting MipA family protein
G6Z48_RS04990	COG2205	protein histidine kinase activity
G6Z48_RS05000	COG0811	peptide transport
G6Z48_RS05015	COG1663	tetraacyldisaccharide 4'-kinase activity
G6Z48_RS05020	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G6Z48_RS05025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G6Z48_RS05035	COG0322	excinuclease ABC activity
G6Z48_RS05050	COG0582	viral genome integration into host DNA
G6Z48_RS05060	COG1396	sequence-specific DNA binding
G6Z48_RS05065	COG0583	DNA-binding transcription factor activity
G6Z48_RS05090	COG0633	Ferredoxin
G6Z48_RS05095	COG0789	Transcriptional regulator
G6Z48_RS05105	COG0640	Transcriptional regulator
G6Z48_RS05110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6Z48_RS05145	COG1937	Protein conserved in bacteria
G6Z48_RS05150	COG2814	Major facilitator Superfamily
G6Z48_RS05155	COG1230	cation diffusion facilitator family transporter
G6Z48_RS05160	COG0640	Transcriptional regulator
G6Z48_RS05170	COG2217	Heavy metal translocating P-type atpase
G6Z48_RS05185	COG2814	Major facilitator Superfamily
G6Z48_RS05200	COG2186	Transcriptional regulator
G6Z48_RS05220	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G6Z48_RS05270	COG2003	Belongs to the UPF0758 family
G6Z48_RS05325	COG3311	Transcriptional regulator
G6Z48_RS05330	COG1569	PIN domain
G6Z48_RS05485	COG0789	Transcriptional regulator
G6Z48_RS05530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G6Z48_RS05540	COG0789	Transcriptional regulator
G6Z48_RS05555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G6Z48_RS05560	COG0629	single-stranded DNA binding
G6Z48_RS05635	COG1136	(ABC) transporter
G6Z48_RS05635	COG0577	efflux transmembrane transporter activity
G6Z48_RS05715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G6Z48_RS05745	COG0583	DNA-binding transcription factor activity
G6Z48_RS05765	COG1917	Cupin 2, conserved barrel domain protein
G6Z48_RS05765	COG4977	sequence-specific DNA binding
G6Z48_RS05770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G6Z48_RS05790	COG0348	domain, Protein
G6Z48_RS05805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G6Z48_RS05820	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G6Z48_RS05825	COG0069	glutamate synthase activity
G6Z48_RS05855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6Z48_RS05870	COG1253	flavin adenine dinucleotide binding
G6Z48_RS05890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G6Z48_RS05905	COG0504	CTP synthase activity
G6Z48_RS05910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G6Z48_RS05925	COG0148	phosphopyruvate hydratase activity
G6Z48_RS05930	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G6Z48_RS05935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G6Z48_RS05940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G6Z48_RS05950	COG2840	Smr protein MutS2
G6Z48_RS05955	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G6Z48_RS05960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G6Z48_RS05985	COG1534	Rna-binding protein
G6Z48_RS05990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G6Z48_RS05995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G6Z48_RS06005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G6Z48_RS06010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G6Z48_RS06015	COG1923	regulation of RNA biosynthetic process
G6Z48_RS06020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G6Z48_RS06025	COG1546	Belongs to the CinA family
G6Z48_RS06030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G6Z48_RS06035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G6Z48_RS06040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G6Z48_RS06045	COG2137	regulation of response to DNA damage stimulus
G6Z48_RS06050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G6Z48_RS06055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G6Z48_RS06105	COG3540	Alkaline phosphatase
G6Z48_RS06125	COG3258	Cytochrome c
G6Z48_RS06140	COG2223	nitrite transmembrane transporter activity
G6Z48_RS06155	COG1741	Belongs to the pirin family
G6Z48_RS06160	COG0583	DNA-binding transcription factor activity
G6Z48_RS06185	COG0351	phosphomethylpyrimidine kinase
G6Z48_RS06185	COG0352	thiamine-phosphate diphosphorylase activity
G6Z48_RS06200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G6Z48_RS06205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G6Z48_RS06215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6Z48_RS06225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G6Z48_RS06230	COG0477	Major facilitator Superfamily
G6Z48_RS06240	COG0617	tRNA 3'-terminal CCA addition
G6Z48_RS06245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G6Z48_RS06250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G6Z48_RS06255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G6Z48_RS06265	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G6Z48_RS06270	COG0166	Belongs to the GPI family
G6Z48_RS06275	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G6Z48_RS06285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G6Z48_RS06290	COG0671	phosphoesterase, PA-phosphatase related
G6Z48_RS06300	COG0800	Aldolase
G6Z48_RS06305	COG0129	dihydroxy-acid dehydratase activity
G6Z48_RS06315	COG0837	glucose binding
G6Z48_RS06340	COG2009	succinate dehydrogenase
G6Z48_RS06345	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G6Z48_RS06350	COG1053	succinate dehydrogenase
G6Z48_RS06370	COG4591	ABC-type transport system involved in lipoprotein release permease component
G6Z48_RS06385	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G6Z48_RS06395	COG0552	protein localization to endoplasmic reticulum
G6Z48_RS06420	COG0742	ribosomal rna small subunit methyltransferase
G6Z48_RS06425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G6Z48_RS06435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G6Z48_RS06440	COG0405	Gamma-glutamyltransferase
G6Z48_RS06445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G6Z48_RS06465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G6Z48_RS06485	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G6Z48_RS06495	COG0415	Belongs to the DNA photolyase family
G6Z48_RS06500	COG2885	chlorophyll binding
G6Z48_RS06505	COG0583	DNA-binding transcription factor activity
G6Z48_RS06605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G6Z48_RS06615	COG2914	Belongs to the UPF0125 (RnfH) family
G6Z48_RS06620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6Z48_RS06625	COG0735	belongs to the Fur family
G6Z48_RS06635	COG0583	DNA-binding transcription factor activity
G6Z48_RS06640	COG0497	DNA recombination
G6Z48_RS06645	COG1420	regulation of RNA biosynthetic process
G6Z48_RS06650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G6Z48_RS06655	COG0443	Heat shock 70 kDa protein
G6Z48_RS06660	COG0484	heat shock protein binding
G6Z48_RS06665	COG2207	Transcriptional regulator
G6Z48_RS06670	COG2223	nitrite transmembrane transporter activity
G6Z48_RS06675	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G6Z48_RS06680	COG1605	Chorismate mutase
G6Z48_RS06680	COG0287	Prephenate dehydrogenase
G6Z48_RS06690	COG1132	(ABC) transporter
G6Z48_RS06720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G6Z48_RS06725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G6Z48_RS06735	COG0343	queuine tRNA-ribosyltransferase activity
G6Z48_RS06740	COG1862	Preprotein translocase
G6Z48_RS06750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G6Z48_RS06755	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G6Z48_RS06765	COG2081	HI0933 family
G6Z48_RS06770	COG4681	YaeQ
G6Z48_RS06790	COG0625	glutathione transferase activity
G6Z48_RS06795	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G6Z48_RS06805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G6Z48_RS06810	COG0513	Belongs to the DEAD box helicase family
G6Z48_RS06820	COG0583	DNA-binding transcription factor activity
G6Z48_RS06850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z48_RS06865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G6Z48_RS06870	COG2957	Belongs to the agmatine deiminase family
G6Z48_RS06880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G6Z48_RS06885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G6Z48_RS06895	COG0776	regulation of translation
G6Z48_RS06905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G6Z48_RS06910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G6Z48_RS06920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G6Z48_RS06925	COG0183	Belongs to the thiolase family
G6Z48_RS06930	COG1024	Enoyl-CoA hydratase
G6Z48_RS06930	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6Z48_RS06940	COG0105	UTP biosynthetic process
G6Z48_RS06945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G6Z48_RS06950	COG0859	PFAM glycosyl transferase family 9
G6Z48_RS06950	COG0457	Tetratricopeptide repeat
G6Z48_RS06955	COG1426	Protein conserved in bacteria
G6Z48_RS06955	COG1426	Protein conserved in bacteria
G6Z48_RS06965	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6Z48_RS06970	COG1160	GTP binding
G6Z48_RS06990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G6Z48_RS06995	COG0475	glutathione-regulated potassium exporter activity
G6Z48_RS06995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G6Z48_RS07010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G6Z48_RS07010	COG0519	Catalyzes the synthesis of GMP from XMP
G6Z48_RS07015	COG0582	viral genome integration into host DNA
G6Z48_RS07035	COG2003	Belongs to the UPF0758 family
G6Z48_RS07055	COG1475	DNA binding
G6Z48_RS07070	COG5489	Protein of unknown function (DUF736)
G6Z48_RS07075	COG1396	sequence-specific DNA binding
G6Z48_RS07100	COG1192	Involved in chromosome partitioning
G6Z48_RS07125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G6Z48_RS07140	COG0556	nucleotide-excision repair
G6Z48_RS07165	COG0583	DNA-binding transcription factor activity
G6Z48_RS07185	COG4962	Type ii secretion system protein e
G6Z48_RS07190	COG3838	Conjugal transfer protein Trbc
G6Z48_RS07200	COG3451	type IV secretory pathway VirB4
G6Z48_RS07215	COG3846	protein secretion by the type IV secretion system
G6Z48_RS07285	COG1006	Multisubunit Na H antiporter MnhC subunit
G6Z48_RS07305	COG1320	monovalent cation:proton antiporter activity
G6Z48_RS07320	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G6Z48_RS07325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6Z48_RS07340	COG0183	Belongs to the thiolase family
G6Z48_RS07345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6Z48_RS07360	COG0598	Magnesium transport protein CorA
G6Z48_RS07365	COG0625	glutathione transferase activity
G6Z48_RS07370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6Z48_RS07390	COG0135	phosphoribosylanthranilate isomerase activity
G6Z48_RS07435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G6Z48_RS07450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G6Z48_RS07460	COG0583	DNA-binding transcription factor activity
G6Z48_RS07500	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS07510	COG0596	Alpha beta hydrolase
G6Z48_RS07525	COG0640	Transcriptional regulator
G6Z48_RS07540	COG4716	Myosin-crossreactive antigen
G6Z48_RS07570	COG4206	TonB-dependent receptor
G6Z48_RS07575	COG0431	NADPH-dependent FMN reductase
G6Z48_RS07585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6Z48_RS07590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6Z48_RS07595	COG1473	amidohydrolase
G6Z48_RS07640	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G6Z48_RS07645	COG0583	DNA-binding transcription factor activity
G6Z48_RS07650	COG0477	Major facilitator Superfamily
G6Z48_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS07665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G6Z48_RS07685	COG1309	transcriptional regulator
G6Z48_RS07700	COG0697	spore germination
G6Z48_RS07705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G6Z48_RS07710	COG0167	dihydroorotate dehydrogenase activity
G6Z48_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS07730	COG1012	belongs to the aldehyde dehydrogenase family
G6Z48_RS07770	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS07775	COG0784	Response regulator, receiver
G6Z48_RS07775	COG4191	Histidine kinase
G6Z48_RS07780	COG4999	Histidine kinase
G6Z48_RS07780	COG3850	Histidine kinase
G6Z48_RS07780	COG3437	response regulator, receiver
G6Z48_RS07780	COG2205	protein histidine kinase activity
G6Z48_RS07785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G6Z48_RS07795	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS07800	COG0640	Transcriptional regulator
G6Z48_RS07840	COG0460	homoserine dehydrogenase
G6Z48_RS07840	COG0527	aspartate kinase activity
G6Z48_RS07845	COG0083	homoserine kinase activity
G6Z48_RS07855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G6Z48_RS07860	COG0124	histidyl-tRNA synthetase
G6Z48_RS07870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G6Z48_RS07875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G6Z48_RS07880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G6Z48_RS07885	COG0131	Imidazoleglycerol-phosphate dehydratase
G6Z48_RS07885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G6Z48_RS07890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G6Z48_RS07895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G6Z48_RS07900	COG0107	imidazoleglycerol-phosphate synthase activity
G6Z48_RS07905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G6Z48_RS07905	COG0140	phosphoribosyl-ATP diphosphatase activity
G6Z48_RS07925	COG1446	asparaginase
G6Z48_RS07930	COG3142	Participates in the control of copper homeostasis
G6Z48_RS07940	COG2217	Heavy metal translocating P-type atpase
G6Z48_RS07945	COG0789	Transcriptional regulator
G6Z48_RS07965	COG3537	Alpha-1,2-mannosidase
G6Z48_RS07970	COG1609	Transcriptional regulator
G6Z48_RS07980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6Z48_RS07995	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
G6Z48_RS08000	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
G6Z48_RS08005	COG0235	Class ii aldolase
G6Z48_RS08020	COG0531	amino acid
G6Z48_RS08025	COG0531	amino acid
G6Z48_RS08035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6Z48_RS08040	COG0277	FAD linked oxidase domain protein
G6Z48_RS08055	COG2205	protein histidine kinase activity
G6Z48_RS08060	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS08065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS08085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G6Z48_RS08130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G6Z48_RS08145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G6Z48_RS08150	COG0505	Belongs to the CarA family
G6Z48_RS08155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G6Z48_RS08160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6Z48_RS08175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G6Z48_RS08180	COG4676	Protein conserved in bacteria
G6Z48_RS08190	COG3279	Response regulator of the LytR AlgR family
G6Z48_RS08205	COG1012	belongs to the aldehyde dehydrogenase family
G6Z48_RS08225	COG2205	protein histidine kinase activity
G6Z48_RS08225	COG0784	Response regulator, receiver
G6Z48_RS08225	COG2198	Histidine kinase
G6Z48_RS08230	COG1024	Enoyl-CoA hydratase
G6Z48_RS08235	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z48_RS08240	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G6Z48_RS08245	COG1012	belongs to the aldehyde dehydrogenase family
G6Z48_RS08250	COG1309	transcriptional regulator
G6Z48_RS08255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G6Z48_RS08300	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G6Z48_RS08310	COG0840	transmembrane signaling receptor activity
G6Z48_RS08315	COG0840	transmembrane signaling receptor activity
G6Z48_RS08325	COG0835	chemotaxis
G6Z48_RS08330	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G6Z48_RS08335	COG0840	transmembrane signaling receptor activity
G6Z48_RS08345	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS08355	COG0835	chemotaxis
G6Z48_RS08365	COG1360	Flagellar Motor Protein
G6Z48_RS08370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G6Z48_RS08375	COG0643	Histidine kinase
G6Z48_RS08375	COG0784	Response regulator, receiver
G6Z48_RS08375	COG2198	Histidine kinase
G6Z48_RS08380	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G6Z48_RS08405	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G6Z48_RS08410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G6Z48_RS08430	COG1987	bacterial-type flagellum assembly
G6Z48_RS08440	COG3190	flagellar
G6Z48_RS08490	COG1677	Flagellar hook-basal body complex protein FliE
G6Z48_RS08520	COG2197	response regulator
G6Z48_RS08540	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G6Z48_RS08550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G6Z48_RS08580	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G6Z48_RS08590	COG4787	bacterial-type flagellum-dependent cell motility
G6Z48_RS08605	COG1558	bacterial-type flagellum-dependent cell motility
G6Z48_RS08610	COG1815	bacterial-type flagellum-dependent cell motility
G6Z48_RS08615	COG0784	Response regulator, receiver
G6Z48_RS08615	COG0835	chemotaxis
G6Z48_RS08635	COG5002	protein histidine kinase activity
G6Z48_RS08670	COG2915	High frequency lysogenization protein hflD homolog
G6Z48_RS08675	COG0482	sulfurtransferase activity
G6Z48_RS08690	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G6Z48_RS08700	COG0542	response to heat
G6Z48_RS08730	COG0492	ferredoxin-NADP+ reductase activity
G6Z48_RS08735	COG1674	ftsk spoiiie
G6Z48_RS08750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G6Z48_RS08765	COG2819	hydrolase of the alpha beta superfamily
G6Z48_RS08775	COG4558	Periplasmic binding protein
G6Z48_RS08780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6Z48_RS08785	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G6Z48_RS08795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G6Z48_RS08810	COG0784	Response regulator, receiver
G6Z48_RS08810	COG5002	protein histidine kinase activity
G6Z48_RS08840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G6Z48_RS08850	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G6Z48_RS08865	COG1595	DNA-templated transcription, initiation
G6Z48_RS08885	COG0784	Response regulator, receiver
G6Z48_RS08890	COG4251	negative regulation of phosphorylation
G6Z48_RS08900	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
G6Z48_RS09100	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G6Z48_RS09105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G6Z48_RS09110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G6Z48_RS09115	COG2080	2 iron, 2 sulfur cluster binding
G6Z48_RS09125	COG1764	response to oxidative stress
G6Z48_RS09135	COG0583	DNA-binding transcription factor activity
G6Z48_RS09155	COG1595	DNA-templated transcription, initiation
G6Z48_RS09160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G6Z48_RS09175	COG0300	oxidoreductase activity
G6Z48_RS09220	COG3685	Protein conserved in bacteria
G6Z48_RS09245	COG3546	catalase activity
G6Z48_RS09250	COG3685	Protein conserved in bacteria
G6Z48_RS09275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G6Z48_RS09295	COG1063	alcohol dehydrogenase
G6Z48_RS09325	COG1609	Transcriptional regulator
G6Z48_RS09330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G6Z48_RS09330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G6Z48_RS09335	COG1105	Belongs to the carbohydrate kinase PfkB family
G6Z48_RS09340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G6Z48_RS09340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G6Z48_RS09355	COG1733	regulation of RNA biosynthetic process
G6Z48_RS09360	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
G6Z48_RS09375	COG4771	TonB-dependent receptor
G6Z48_RS09380	COG0738	Major facilitator superfamily
G6Z48_RS09385	COG1609	Transcriptional regulator
G6Z48_RS09390	COG1472	Belongs to the glycosyl hydrolase 3 family
G6Z48_RS09405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6Z48_RS09420	COG2828	Protein conserved in bacteria
G6Z48_RS09425	COG0583	DNA-binding transcription factor activity
G6Z48_RS09455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G6Z48_RS09460	COG0583	DNA-binding transcription factor activity
G6Z48_RS09490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G6Z48_RS09515	COG2205	protein histidine kinase activity
G6Z48_RS09525	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z48_RS09540	COG2186	Transcriptional regulator
G6Z48_RS09560	COG2271	Major facilitator Superfamily
G6Z48_RS09565	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS09575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6Z48_RS09600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6Z48_RS09620	COG0583	DNA-binding transcription factor activity
G6Z48_RS09645	COG2204	response regulator
G6Z48_RS09725	COG0708	Exodeoxyribonuclease III
G6Z48_RS09730	COG0366	Alpha amylase catalytic
G6Z48_RS09735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6Z48_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS09755	COG0577	efflux transmembrane transporter activity
G6Z48_RS09755	COG1136	(ABC) transporter
G6Z48_RS09760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS09770	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS09775	COG2205	protein histidine kinase activity
G6Z48_RS09785	COG3214	Protein conserved in bacteria
G6Z48_RS09795	COG4774	siderophore transport
G6Z48_RS09815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G6Z48_RS09820	COG1285	pathogenesis
G6Z48_RS09825	COG4191	Histidine kinase
G6Z48_RS09830	COG4566	intracellular signal transduction
G6Z48_RS09890	COG0243	molybdopterin cofactor binding
G6Z48_RS09915	COG0477	Major facilitator Superfamily
G6Z48_RS09955	COG0583	DNA-binding transcription factor activity
G6Z48_RS09960	COG0656	L-ascorbic acid biosynthetic process
G6Z48_RS09980	COG0583	DNA-binding transcription factor activity
G6Z48_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS10010	COG0642	Histidine kinase
G6Z48_RS10015	COG3537	Alpha-1,2-mannosidase
G6Z48_RS10030	COG0477	Major facilitator Superfamily
G6Z48_RS10050	COG3920	Histidine kinase
G6Z48_RS10050	COG2202	Pas domain
G6Z48_RS10095	COG1335	isochorismatase
G6Z48_RS10100	COG1335	isochorismatase
G6Z48_RS10130	COG0811	peptide transport
G6Z48_RS10225	COG1595	DNA-templated transcription, initiation
G6Z48_RS10270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G6Z48_RS10275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G6Z48_RS10285	COG0840	transmembrane signaling receptor activity
G6Z48_RS10290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G6Z48_RS10295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G6Z48_RS10300	COG4149	molybdate abc transporter
G6Z48_RS10305	COG0725	ABC transporter, periplasmic molybdate-binding protein
G6Z48_RS10310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G6Z48_RS10325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6Z48_RS10330	COG2181	nitrate reductase activity
G6Z48_RS10335	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G6Z48_RS10340	COG1140	nitrate reductase beta subunit
G6Z48_RS10345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G6Z48_RS10350	COG2223	nitrite transmembrane transporter activity
G6Z48_RS10360	COG0746	molybdenum cofactor guanylyltransferase activity
G6Z48_RS10365	COG0314	molybdopterin synthase activity
G6Z48_RS10375	COG0303	'Molybdopterin
G6Z48_RS10380	COG0521	Mo-molybdopterin cofactor biosynthetic process
G6Z48_RS10380	COG0315	cyclic pyranopterin monophosphate synthase activity
G6Z48_RS10385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G6Z48_RS10440	COG2207	Transcriptional regulator
G6Z48_RS10480	COG2205	protein histidine kinase activity
G6Z48_RS10490	COG2194	sulfuric ester hydrolase activity
G6Z48_RS10525	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS10530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G6Z48_RS10530	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G6Z48_RS10535	COG1535	isochorismatase
G6Z48_RS10535	COG3433	isochorismatase activity
G6Z48_RS10540	COG3433	isochorismatase activity
G6Z48_RS10540	COG1535	isochorismatase
G6Z48_RS10545	COG1021	2,3-dihydroxybenzoate-AMP ligase
G6Z48_RS10550	COG1169	isochorismate synthase
G6Z48_RS10560	COG2409	Drug exporters of the RND superfamily
G6Z48_RS10565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6Z48_RS10635	COG1914	H( )-stimulated, divalent metal cation uptake system
G6Z48_RS10650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G6Z48_RS10655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G6Z48_RS10660	COG0604	alcohol dehydrogenase
G6Z48_RS10660	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS10660	COG3321	synthase
G6Z48_RS10665	COG2801	Transposase and inactivated derivatives
G6Z48_RS10665	COG3415	Transposase
G6Z48_RS10670	COG4206	TonB-dependent receptor
G6Z48_RS10675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G6Z48_RS10720	COG4772	TonB-dependent receptor
G6Z48_RS10740	COG2226	methyltransferase
G6Z48_RS10785	COG4964	Belongs to the GSP D family
G6Z48_RS10840	COG2814	Major facilitator Superfamily
G6Z48_RS10850	COG1228	amidohydrolase
G6Z48_RS10860	COG1335	isochorismatase
G6Z48_RS10875	COG3850	Histidine kinase
G6Z48_RS10880	COG2197	response regulator
G6Z48_RS10885	COG2814	Major facilitator Superfamily
G6Z48_RS10895	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G6Z48_RS10905	COG0583	DNA-binding transcription factor activity
G6Z48_RS10920	COG3161	chorismate lyase activity
G6Z48_RS10960	COG0277	FAD linked oxidase domain protein
G6Z48_RS10965	COG1304	FMN binding
G6Z48_RS10970	COG2186	Transcriptional regulator
G6Z48_RS10980	COG1285	pathogenesis
G6Z48_RS11005	COG2814	Major facilitator Superfamily
G6Z48_RS11060	COG0587	DNA-directed DNA polymerase activity
G6Z48_RS11075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G6Z48_RS11080	COG0519	Catalyzes the synthesis of GMP from XMP
G6Z48_RS11080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G6Z48_RS11095	COG1595	DNA-templated transcription, initiation
G6Z48_RS11105	COG1629	transport
G6Z48_RS11105	COG4206	TonB-dependent receptor
G6Z48_RS11130	COG1982	Orn Lys Arg decarboxylase major
G6Z48_RS11135	COG0531	amino acid
G6Z48_RS11150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6Z48_RS11160	COG0789	Transcriptional regulator
G6Z48_RS11335	COG0740	serine-type endopeptidase activity
G6Z48_RS11385	COG3179	chitinase
G6Z48_RS11395	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
G6Z48_RS11585	COG5001	Diguanylate cyclase
G6Z48_RS11585	COG3447	MASE1 domain protein
G6Z48_RS11585	COG5002	protein histidine kinase activity
G6Z48_RS11590	COG2183	response to ionizing radiation
G6Z48_RS11605	COG1983	PspC domain protein
G6Z48_RS11615	COG3243	poly(R)-hydroxyalkanoic acid synthase
G6Z48_RS11630	COG1073	alpha beta
G6Z48_RS11630	COG2226	methyltransferase
G6Z48_RS11635	COG0534	Mate efflux family protein
G6Z48_RS11655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G6Z48_RS11665	COG0668	transmembrane transport
G6Z48_RS11680	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G6Z48_RS11690	COG1733	regulation of RNA biosynthetic process
G6Z48_RS11695	COG2249	NAD(P)H dehydrogenase (quinone) activity
G6Z48_RS11775	COG3702	type iv secretory pathway
G6Z48_RS11795	COG2948	multi-organism process
G6Z48_RS11805	COG3736	Type IV secretory pathway, component VirB8
G6Z48_RS11815	COG3505	Type IV secretory pathway VirD4
G6Z48_RS11830	COG2814	Major facilitator Superfamily
G6Z48_RS11835	COG0789	Transcriptional regulator
G6Z48_RS11870	COG0784	Response regulator, receiver
G6Z48_RS11870	COG4191	Histidine kinase
G6Z48_RS11885	COG4774	siderophore transport
G6Z48_RS11905	COG1733	regulation of RNA biosynthetic process
G6Z48_RS11910	COG0604	alcohol dehydrogenase
G6Z48_RS11920	COG0210	DNA helicase
G6Z48_RS11935	COG0583	DNA-binding transcription factor activity
G6Z48_RS11940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G6Z48_RS11945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G6Z48_RS11960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G6Z48_RS11965	COG1605	Chorismate mutase
G6Z48_RS11965	COG0077	Prephenate dehydratase
G6Z48_RS11970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G6Z48_RS12020	COG1228	amidohydrolase
G6Z48_RS12035	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G6Z48_RS12085	COG2957	Belongs to the agmatine deiminase family
G6Z48_RS12090	COG0583	DNA-binding transcription factor activity
G6Z48_RS12140	COG3415	Transposase
G6Z48_RS12140	COG2801	Transposase and inactivated derivatives
G6Z48_RS12145	COG4993	Dehydrogenase
G6Z48_RS12155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G6Z48_RS12165	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G6Z48_RS12175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G6Z48_RS12180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G6Z48_RS12195	COG0359	binds to the 23S rRNA
G6Z48_RS12200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G6Z48_RS12205	COG0360	Binds together with S18 to 16S ribosomal RNA
G6Z48_RS12215	COG0316	Belongs to the HesB IscA family
G6Z48_RS12220	COG0017	Asparaginyl-tRNA synthetase
G6Z48_RS12240	COG0288	reversible hydration of carbon dioxide
G6Z48_RS12250	COG3844	kynureninase activity
G6Z48_RS12255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6Z48_RS12260	COG2925	Exonuclease
G6Z48_RS12285	COG2902	Dehydrogenase
G6Z48_RS12295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS12300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z48_RS12315	COG1960	acyl-CoA dehydrogenase activity
G6Z48_RS12320	COG2226	methyltransferase
G6Z48_RS12330	COG1410	methionine synthase
G6Z48_RS12330	COG0646	methionine synthase
G6Z48_RS12345	COG2900	Belongs to the SlyX family
G6Z48_RS12360	COG0386	Belongs to the glutathione peroxidase family
G6Z48_RS12370	COG1725	Transcriptional regulator
G6Z48_RS12375	COG1131	(ABC) transporter
G6Z48_RS12400	COG0114	fumarate hydratase activity
G6Z48_RS12415	COG2850	peptidyl-arginine hydroxylation
G6Z48_RS12425	COG0567	Dehydrogenase, E1 component
G6Z48_RS12450	COG3540	Alkaline phosphatase
G6Z48_RS12460	COG0305	Participates in initiation and elongation during chromosome replication
G6Z48_RS12480	COG0625	glutathione transferase activity
G6Z48_RS12500	COG0084	hydrolase, TatD family'
G6Z48_RS12505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G6Z48_RS12540	COG0625	glutathione transferase activity
G6Z48_RS12555	COG1595	DNA-templated transcription, initiation
G6Z48_RS12560	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6Z48_RS12575	COG0386	Belongs to the glutathione peroxidase family
G6Z48_RS12580	COG0339	signal peptide processing
G6Z48_RS12590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G6Z48_RS12610	COG0705	Rhomboid family
G6Z48_RS12615	COG3104	oligopeptide transport
G6Z48_RS12625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G6Z48_RS12630	COG4290	ribonuclease
G6Z48_RS12645	COG0316	Belongs to the HesB IscA family
G6Z48_RS12645	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G6Z48_RS12650	COG2154	pterin-4-alpha-carbinolamine dehydratase
G6Z48_RS12660	COG0428	transporter
G6Z48_RS12670	COG1530	ribonuclease E activity
G6Z48_RS12685	COG0395	ABC-type sugar transport system, permease component
G6Z48_RS12715	COG0271	Belongs to the BolA IbaG family
G6Z48_RS12720	COG2350	Protein conserved in bacteria
G6Z48_RS12725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G6Z48_RS12730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G6Z48_RS12735	COG1187	pseudouridine synthase activity
G6Z48_RS12745	COG2814	Major facilitator Superfamily
G6Z48_RS12765	COG0436	Aminotransferase
G6Z48_RS12770	COG4133	protoheme IX ABC transporter activity
G6Z48_RS12790	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G6Z48_RS12805	COG3088	subunit of a heme lyase
G6Z48_RS12805	COG4235	cytochrome complex assembly
G6Z48_RS12815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G6Z48_RS12825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G6Z48_RS12830	COG4988	ABC transporter
G6Z48_RS12840	COG1294	oxidase, subunit
G6Z48_RS12870	COG0726	polysaccharide deacetylase
G6Z48_RS12870	COG1649	PFAM Uncharacterised BCR, COG1649
G6Z48_RS12875	COG1215	transferase activity, transferring glycosyl groups
G6Z48_RS12885	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G6Z48_RS12900	COG0165	Argininosuccinate lyase
G6Z48_RS12905	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G6Z48_RS12915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G6Z48_RS12920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6Z48_RS12925	COG0137	argininosuccinate synthase activity
G6Z48_RS12930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G6Z48_RS12945	COG2166	iron-sulfur cluster assembly
G6Z48_RS12965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G6Z48_RS12985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G6Z48_RS12990	COG0402	S-adenosylhomocysteine deaminase activity
G6Z48_RS12995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G6Z48_RS13000	COG1509	lysine 2,3-aminomutase activity
G6Z48_RS13005	COG5001	Diguanylate cyclase
G6Z48_RS13005	COG3300	MHYT domain
G6Z48_RS13025	COG0501	Belongs to the peptidase M48B family
G6Z48_RS13035	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS13055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G6Z48_RS13060	COG0860	N-Acetylmuramoyl-L-alanine amidase
G6Z48_RS13065	COG0802	atpase or kinase
G6Z48_RS13070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G6Z48_RS13070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G6Z48_RS13075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G6Z48_RS13080	COG1570	exodeoxyribonuclease VII activity
G6Z48_RS13095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G6Z48_RS13115	COG4771	TonB-dependent receptor
G6Z48_RS13140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G6Z48_RS13140	COG2169	Transcriptional regulator
G6Z48_RS13145	COG2130	NADP-dependent
G6Z48_RS13170	COG1960	acyl-CoA dehydrogenase activity
G6Z48_RS13180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G6Z48_RS13215	COG2076	Multidrug Resistance protein
G6Z48_RS13220	COG5487	UPF0391 membrane protein
G6Z48_RS13225	COG1280	lysine exporter protein (LysE YggA)
G6Z48_RS13230	COG0740	serine-type endopeptidase activity
G6Z48_RS13245	COG1794	racemase activity, acting on amino acids and derivatives
G6Z48_RS13280	COG0776	regulation of translation
G6Z48_RS13285	COG0072	phenylalanine-tRNA ligase activity
G6Z48_RS13285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z48_RS13290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G6Z48_RS13295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G6Z48_RS13300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G6Z48_RS13305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G6Z48_RS13310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G6Z48_RS13340	COG1185	polyribonucleotide nucleotidyltransferase activity
G6Z48_RS13345	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G6Z48_RS13355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G6Z48_RS13360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G6Z48_RS13365	COG0195	Participates in both transcription termination and antitermination
G6Z48_RS13370	COG0779	Required for maturation of 30S ribosomal subunits
G6Z48_RS13385	COG1007	ATP synthesis coupled electron transport
G6Z48_RS13400	COG0713	ATP synthesis coupled electron transport
G6Z48_RS13410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6Z48_RS13415	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G6Z48_RS13430	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G6Z48_RS13435	COG0649	NAD binding
G6Z48_RS13440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6Z48_RS13445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6Z48_RS13450	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6Z48_RS13465	COG0149	triose-phosphate isomerase activity
G6Z48_RS13480	COG3083	sulfuric ester hydrolase activity
G6Z48_RS13485	COG0438	transferase activity, transferring glycosyl groups
G6Z48_RS13490	COG0726	polysaccharide deacetylase
G6Z48_RS13495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G6Z48_RS13500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G6Z48_RS13505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G6Z48_RS13510	COG0159	tryptophan synthase activity
G6Z48_RS13520	COG0133	tryptophan synthase activity
G6Z48_RS13540	COG0135	phosphoribosylanthranilate isomerase activity
G6Z48_RS13545	COG0101	tRNA pseudouridine synthase activity
G6Z48_RS13560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G6Z48_RS13570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G6Z48_RS13575	COG2890	protein-(glutamine-N5) methyltransferase activity
G6Z48_RS13580	COG1999	signal sequence binding
G6Z48_RS13585	COG0688	phosphatidylethanolamine metabolic process
G6Z48_RS13600	COG0433	COG0433 Predicted ATPase
G6Z48_RS13605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6Z48_RS13615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G6Z48_RS13620	COG0412	Dienelactone hydrolase
G6Z48_RS13635	COG0717	Belongs to the dCTP deaminase family
G6Z48_RS13640	COG0489	protein tyrosine kinase activity
G6Z48_RS13645	COG4771	TonB-dependent receptor
G6Z48_RS13650	COG4771	TonB-dependent receptor
G6Z48_RS13655	COG3590	peptidase
G6Z48_RS13690	COG0697	spore germination
G6Z48_RS13700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z48_RS13705	COG2311	Membrane
G6Z48_RS13710	COG1047	Peptidyl-prolyl cis-trans
G6Z48_RS13715	COG0791	NLP P60 protein
G6Z48_RS13720	COG0791	NLP P60 protein
G6Z48_RS13725	COG1301	dicarboxylic acid transport
G6Z48_RS13745	COG1722	exodeoxyribonuclease VII activity
G6Z48_RS13750	COG0142	geranyltranstransferase activity
G6Z48_RS13760	COG0312	modulator of DNA gyrase
G6Z48_RS13765	COG3028	Belongs to the UPF0307 family
G6Z48_RS13770	COG0312	modulator of DNA gyrase
G6Z48_RS13780	COG1530	ribonuclease E activity
G6Z48_RS13790	COG2968	Membrane
G6Z48_RS13800	COG4771	TonB-dependent receptor
G6Z48_RS13815	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G6Z48_RS13825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G6Z48_RS13840	COG0495	leucyl-tRNA aminoacylation
G6Z48_RS13850	COG3118	belongs to the thioredoxin family
G6Z48_RS13860	COG2203	Gaf domain
G6Z48_RS13860	COG3706	GGDEF domain
G6Z48_RS13860	COG5001	Diguanylate cyclase
G6Z48_RS13860	COG4251	negative regulation of phosphorylation
G6Z48_RS13880	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G6Z48_RS13890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G6Z48_RS13895	COG0346	lactoylglutathione lyase activity
G6Z48_RS13905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z48_RS13905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6Z48_RS13915	COG2878	Part of a membrane complex involved in electron transport
G6Z48_RS13920	COG0251	oxidation-reduction process
G6Z48_RS13925	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G6Z48_RS13925	COG0392	lysyltransferase activity
G6Z48_RS13955	COG2824	Alkylphosphonate utilization operon protein PhnA
G6Z48_RS13960	COG0443	Heat shock 70 kDa protein
G6Z48_RS14000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G6Z48_RS14005	COG3122	Protein conserved in bacteria
G6Z48_RS14010	COG1451	nucleotide metabolic process
G6Z48_RS14020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6Z48_RS14040	COG0183	Belongs to the thiolase family
G6Z48_RS14055	COG1960	acyl-CoA dehydrogenase activity
G6Z48_RS14065	COG1793	dna ligase
G6Z48_RS14070	COG1201	RNA secondary structure unwinding
G6Z48_RS14085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6Z48_RS14090	COG1278	Cold shock
G6Z48_RS14095	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G6Z48_RS14105	COG1472	Belongs to the glycosyl hydrolase 3 family
G6Z48_RS14110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G6Z48_RS14115	COG2954	triphosphatase activity
G6Z48_RS14120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G6Z48_RS14125	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS14140	COG1381	Involved in DNA repair and RecF pathway recombination
G6Z48_RS14145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G6Z48_RS14160	COG0681	Belongs to the peptidase S26 family
G6Z48_RS14165	COG0481	GTPase activity
G6Z48_RS14170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G6Z48_RS14190	COG1741	Belongs to the pirin family
G6Z48_RS14195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G6Z48_RS14205	COG1741	Belongs to the pirin family
G6Z48_RS14210	COG1966	Carbon starvation protein
G6Z48_RS14215	COG2879	small protein
G6Z48_RS14230	COG2205	protein histidine kinase activity
G6Z48_RS14270	COG2814	Major facilitator Superfamily
G6Z48_RS14275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G6Z48_RS14275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G6Z48_RS14285	COG1113	amino acid transport
G6Z48_RS14290	COG2207	Transcriptional regulator
G6Z48_RS14290	COG1917	Cupin 2, conserved barrel domain protein
G6Z48_RS14295	COG0753	catalase activity
G6Z48_RS14325	COG1376	ErfK ybiS ycfS ynhG family protein
G6Z48_RS14330	COG0739	heme binding
G6Z48_RS14340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G6Z48_RS14350	COG0330	HflC and HflK could
G6Z48_RS14355	COG0330	HflC and HflK could
G6Z48_RS14360	COG0604	alcohol dehydrogenase
G6Z48_RS14375	COG0678	peroxiredoxin activity
G6Z48_RS14385	COG4953	penicillin-binding protein 1C
G6Z48_RS14390	COG2373	Large extracellular alpha-helical protein
G6Z48_RS14395	COG2079	MmgE PrpD family protein
G6Z48_RS14400	COG2828	Protein conserved in bacteria
G6Z48_RS14420	COG3829	transcription factor binding
G6Z48_RS14440	COG0259	pyridoxamine-phosphate oxidase activity
G6Z48_RS14455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G6Z48_RS14475	COG0477	Major facilitator Superfamily
G6Z48_RS14480	COG5002	protein histidine kinase activity
G6Z48_RS14480	COG2198	Histidine kinase
G6Z48_RS14480	COG0784	Response regulator, receiver
G6Z48_RS14495	COG3038	cytochrome b561
G6Z48_RS14510	COG1760	l-serine dehydratase
G6Z48_RS14515	COG0596	Alpha beta hydrolase
G6Z48_RS14520	COG0527	aspartate kinase activity
G6Z48_RS14520	COG0460	homoserine dehydrogenase
G6Z48_RS14525	COG0626	cystathionine gamma-synthase activity
G6Z48_RS14530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G6Z48_RS14535	COG0739	heme binding
G6Z48_RS14540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G6Z48_RS14545	COG1272	protein, Hemolysin III
G6Z48_RS14565	COG0463	Glycosyl transferase, family 2
G6Z48_RS14570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G6Z48_RS14575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G6Z48_RS14590	COG1309	transcriptional regulator
G6Z48_RS14600	COG1960	acyl-CoA dehydrogenase activity
G6Z48_RS14630	COG0583	DNA-binding transcription factor activity
G6Z48_RS14640	COG0509	glycine decarboxylation via glycine cleavage system
G6Z48_RS14645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G6Z48_RS14655	COG0330	HflC and HflK could
G6Z48_RS14665	COG1742	UPF0060 membrane protein
G6Z48_RS14670	COG3956	TIGRFAM MazG family protein
G6Z48_RS14680	COG0494	nUDIX hydrolase
G6Z48_RS14690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G6Z48_RS14705	COG0643	Histidine kinase
G6Z48_RS14705	COG2198	Histidine kinase
G6Z48_RS14705	COG0784	Response regulator, receiver
G6Z48_RS14710	COG0840	transmembrane signaling receptor activity
G6Z48_RS14715	COG0835	chemotaxis
G6Z48_RS14730	COG0189	ligase activity
G6Z48_RS14745	COG1199	ATP-dependent helicase activity
G6Z48_RS14755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G6Z48_RS14760	COG1215	transferase activity, transferring glycosyl groups
G6Z48_RS14775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G6Z48_RS14785	COG1643	Atp-dependent helicase
G6Z48_RS14790	COG0783	Belongs to the Dps family
G6Z48_RS14795	COG0514	ATP-dependent DNA helicase (RecQ)
G6Z48_RS14805	COG2132	Multicopper oxidase
G6Z48_RS14995	COG0305	Participates in initiation and elongation during chromosome replication
G6Z48_RS15120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G6Z48_RS15125	COG0602	queuosine metabolic process
G6Z48_RS15135	COG2885	chlorophyll binding
G6Z48_RS15140	COG0823	Involved in the tonB-independent uptake of proteins
G6Z48_RS15155	COG0811	peptide transport
G6Z48_RS15160	COG0824	Thioesterase
G6Z48_RS15165	COG2255	four-way junction helicase activity
G6Z48_RS15175	COG0632	four-way junction helicase activity
G6Z48_RS15180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G6Z48_RS15185	COG0217	transcriptional regulatory protein
G6Z48_RS15205	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G6Z48_RS15235	COG0488	(ABC) transporter
G6Z48_RS15260	COG4651	solute:proton antiporter activity
G6Z48_RS15260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G6Z48_RS15270	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS15275	COG2205	protein histidine kinase activity
G6Z48_RS15285	COG0542	response to heat
G6Z48_RS15310	COG0028	Belongs to the TPP enzyme family
G6Z48_RS15335	COG3387	PFAM Glycoside hydrolase 15-related
G6Z48_RS15340	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G6Z48_RS15345	COG3011	Protein conserved in bacteria
G6Z48_RS15360	COG0564	pseudouridine synthase activity
G6Z48_RS15365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6Z48_RS15375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G6Z48_RS15375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G6Z48_RS15385	COG0045	succinate-CoA ligase (ADP-forming) activity
G6Z48_RS15420	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G6Z48_RS15440	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS15455	COG0189	ligase activity
G6Z48_RS15550	COG3240	lipase activity
G6Z48_RS15550	COG4625	pathogenesis
G6Z48_RS15560	COG2022	thiamine diphosphate biosynthetic process
G6Z48_RS15565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G6Z48_RS15570	COG0471	metal ion transport
G6Z48_RS15570	COG3273	potassium ion transport
G6Z48_RS15590	COG1970	mechanosensitive ion channel activity
G6Z48_RS15600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6Z48_RS15605	COG1115	amino acid carrier protein
G6Z48_RS15615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z48_RS15620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS15645	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G6Z48_RS15655	COG3588	fructose-bisphosphate aldolase
G6Z48_RS15660	COG0469	pyruvate kinase activity
G6Z48_RS15670	COG0126	phosphoglycerate kinase activity
G6Z48_RS15685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G6Z48_RS15730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G6Z48_RS15735	COG1301	dicarboxylic acid transport
G6Z48_RS15765	COG0714	Associated with various cellular activities
G6Z48_RS15795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G6Z48_RS15845	COG0254	rRNA binding
G6Z48_RS15855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G6Z48_RS15865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G6Z48_RS15870	COG1758	RNA polymerase activity
G6Z48_RS15885	COG0437	4 iron, 4 sulfur cluster binding
G6Z48_RS15890	COG2864	formate dehydrogenase
G6Z48_RS15905	COG1921	L-seryl-tRNASec selenium transferase activity
G6Z48_RS15910	COG3276	selenocysteine insertion sequence binding
G6Z48_RS15920	COG0709	Synthesizes selenophosphate from selenide and ATP
G6Z48_RS15925	COG1561	YicC-like family, N-terminal region
G6Z48_RS15930	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G6Z48_RS15935	COG0346	lactoylglutathione lyase activity
G6Z48_RS15945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G6Z48_RS15960	COG0006	proline dipeptidase activity
G6Z48_RS15965	COG0006	proline dipeptidase activity
G6Z48_RS15970	COG3079	Belongs to the UPF0149 family
G6Z48_RS15990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G6Z48_RS16000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G6Z48_RS16010	COG2912	Transglutaminase-like superfamily
G6Z48_RS16015	COG1773	rubredoxin
G6Z48_RS16020	COG0352	thiamine-phosphate diphosphorylase activity
G6Z48_RS16025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G6Z48_RS16030	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
G6Z48_RS16040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G6Z48_RS16045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G6Z48_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS16075	COG0671	phosphoesterase, PA-phosphatase related
G6Z48_RS16085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G6Z48_RS16090	COG0563	adenylate kinase activity
G6Z48_RS16110	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G6Z48_RS16120	COG0848	biopolymer transport protein
G6Z48_RS16130	COG2832	Protein of unknown function (DUF454)
G6Z48_RS16165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G6Z48_RS16190	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS16200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G6Z48_RS16205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G6Z48_RS16210	COG0405	Gamma-glutamyltransferase
G6Z48_RS16215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G6Z48_RS16235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6Z48_RS16240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G6Z48_RS16255	COG0473	3-isopropylmalate dehydrogenase activity
G6Z48_RS16270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z48_RS16275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS16285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G6Z48_RS16290	COG1538	Outer membrane efflux protein
G6Z48_RS16295	COG0531	amino acid
G6Z48_RS16300	COG1519	Transferase
G6Z48_RS16305	COG1560	Kdo2-lipid A biosynthetic process
G6Z48_RS16345	COG1301	dicarboxylic acid transport
G6Z48_RS16355	COG4191	Histidine kinase
G6Z48_RS16370	COG0642	Histidine kinase
G6Z48_RS16385	COG2851	Citrate transporter
G6Z48_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS16410	COG1162	GTPase activity
G6Z48_RS16415	COG0436	Aminotransferase
G6Z48_RS16435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G6Z48_RS16450	COG1228	amidohydrolase
G6Z48_RS16455	COG0804	urea catabolic process
G6Z48_RS16465	COG1307	EDD domain protein, DegV family
G6Z48_RS16505	COG2203	Gaf domain
G6Z48_RS16505	COG3706	GGDEF domain
G6Z48_RS16505	COG5001	Diguanylate cyclase
G6Z48_RS16505	COG4251	negative regulation of phosphorylation
G6Z48_RS16510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G6Z48_RS16520	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G6Z48_RS16540	COG1902	pentaerythritol trinitrate reductase activity
G6Z48_RS16565	COG0583	DNA-binding transcription factor activity
G6Z48_RS16570	COG1064	alcohol dehydrogenase
G6Z48_RS16590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G6Z48_RS16595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G6Z48_RS16605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G6Z48_RS16610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G6Z48_RS16625	COG1522	sequence-specific DNA binding
G6Z48_RS16635	COG4773	Receptor
G6Z48_RS16660	COG0617	tRNA 3'-terminal CCA addition
G6Z48_RS16700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G6Z48_RS16705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G6Z48_RS16710	COG1609	Transcriptional regulator
G6Z48_RS16720	COG0837	glucose binding
G6Z48_RS16730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G6Z48_RS16750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G6Z48_RS16775	COG4191	Histidine kinase
G6Z48_RS16780	COG0784	Response regulator, receiver
G6Z48_RS16785	COG4251	negative regulation of phosphorylation
G6Z48_RS16790	COG2823	Periplasmic or secreted lipoprotein
G6Z48_RS16795	COG0673	inositol 2-dehydrogenase activity
G6Z48_RS16800	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G6Z48_RS16820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G6Z48_RS16830	COG2921	Belongs to the UPF0250 family
G6Z48_RS16840	COG1686	Belongs to the peptidase S11 family
G6Z48_RS16845	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G6Z48_RS16850	COG2951	lytic endotransglycosylase activity
G6Z48_RS16855	COG0772	Belongs to the SEDS family
G6Z48_RS16860	COG0772	Belongs to the SEDS family
G6Z48_RS16875	COG1792	Involved in formation and maintenance of cell shape
G6Z48_RS16880	COG1077	Cell shape determining protein MreB Mrl
G6Z48_RS16885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6Z48_RS16900	COG0308	aminopeptidase N
G6Z48_RS16905	COG2226	methyltransferase
G6Z48_RS16935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z48_RS16950	COG0673	inositol 2-dehydrogenase activity
G6Z48_RS16960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G6Z48_RS16975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G6Z48_RS16985	COG2832	Protein of unknown function (DUF454)
G6Z48_RS17000	COG1505	serine-type exopeptidase activity
G6Z48_RS17025	COG0697	spore germination
G6Z48_RS17030	COG1666	GTP binding
G6Z48_RS17045	COG0339	signal peptide processing
G6Z48_RS17055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G6Z48_RS17075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G6Z48_RS17085	COG1136	(ABC) transporter
G6Z48_RS17090	COG0577	efflux transmembrane transporter activity
G6Z48_RS17090	COG1136	(ABC) transporter
G6Z48_RS17095	COG0577	efflux transmembrane transporter activity
G6Z48_RS17105	COG2204	response regulator
G6Z48_RS17110	COG4191	Histidine kinase
G6Z48_RS17120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G6Z48_RS17130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G6Z48_RS17135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G6Z48_RS17140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G6Z48_RS17145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G6Z48_RS17150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G6Z48_RS17155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G6Z48_RS17165	COG0356	it plays a direct role in the translocation of protons across the membrane
G6Z48_RS17180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6Z48_RS17185	COG0508	dehydrogenase complex catalyzes the overall conversion of
G6Z48_RS17205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G6Z48_RS17230	COG0181	hydroxymethylbilane synthase activity
G6Z48_RS17240	COG2972	Histidine kinase
G6Z48_RS17240	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS17245	COG0400	carboxylic ester hydrolase activity
G6Z48_RS17255	COG4771	TonB-dependent receptor
G6Z48_RS17290	COG0477	Major facilitator Superfamily
G6Z48_RS17335	COG4206	TonB-dependent receptor
G6Z48_RS17355	COG0625	glutathione transferase activity
G6Z48_RS17370	COG2259	Doxx family
G6Z48_RS17390	COG3311	Transcriptional regulator
G6Z48_RS17485	COG0582	viral genome integration into host DNA
G6Z48_RS17505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G6Z48_RS17565	COG1196	nuclear chromosome segregation
G6Z48_RS17850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6Z48_RS17855	COG1490	D-aminoacyl-tRNA deacylase activity
G6Z48_RS17865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G6Z48_RS17905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G6Z48_RS17905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6Z48_RS17910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G6Z48_RS17915	COG0242	peptide deformylase activity
G6Z48_RS17925	COG0758	DNA mediated transformation
G6Z48_RS17930	COG2922	Belongs to the Smg family
G6Z48_RS17940	COG1714	RDD family
G6Z48_RS17945	COG1754	DNA topoisomerase type I activity
G6Z48_RS17945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G6Z48_RS17950	COG0009	L-threonylcarbamoyladenylate synthase
G6Z48_RS17965	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS17975	COG0616	signal peptide processing
G6Z48_RS17980	COG0534	Mate efflux family protein
G6Z48_RS17995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G6Z48_RS18000	COG0625	glutathione transferase activity
G6Z48_RS18010	COG1252	NADH dehydrogenase
G6Z48_RS18030	COG2860	membrane
G6Z48_RS18035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G6Z48_RS18055	COG1846	Transcriptional regulator
G6Z48_RS18060	COG2205	protein histidine kinase activity
G6Z48_RS18065	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS18085	COG0459	protein refolding
G6Z48_RS18090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G6Z48_RS18095	COG2356	endonuclease I
G6Z48_RS18100	COG1324	tolerance protein
G6Z48_RS18110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6Z48_RS18140	COG4585	Histidine kinase
G6Z48_RS18160	COG0583	DNA-binding transcription factor activity
G6Z48_RS18175	COG1785	Belongs to the alkaline phosphatase family
G6Z48_RS18180	COG1686	Belongs to the peptidase S11 family
G6Z48_RS18190	COG2249	NAD(P)H dehydrogenase (quinone) activity
G6Z48_RS18200	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G6Z48_RS18210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G6Z48_RS18215	COG0511	ligase activity, forming carbon-carbon bonds
G6Z48_RS18220	COG0439	Biotin carboxylase
G6Z48_RS18235	COG2264	protein methyltransferase activity
G6Z48_RS18245	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G6Z48_RS18250	COG4589	Belongs to the CDS family
G6Z48_RS18255	COG0204	Acyl-transferase
G6Z48_RS18265	COG0671	phosphoesterase, PA-phosphatase related
G6Z48_RS18265	COG2453	phosphatase
G6Z48_RS18270	COG2267	carboxylic ester hydrolase activity
G6Z48_RS18275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G6Z48_RS18280	COG0138	bifunctional purine biosynthesis protein purh
G6Z48_RS18285	COG0151	Belongs to the GarS family
G6Z48_RS18300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6Z48_RS18305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G6Z48_RS18310	COG2201	protein-glutamate methylesterase activity
G6Z48_RS18315	COG2177	Part of the ABC transporter FtsEX involved in
G6Z48_RS18320	COG2884	Cell division ATP-binding protein ftsE
G6Z48_RS18330	COG3118	belongs to the thioredoxin family
G6Z48_RS18335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G6Z48_RS18340	COG3706	GGDEF domain
G6Z48_RS18350	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G6Z48_RS18385	COG1652	LysM domain
G6Z48_RS18390	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G6Z48_RS18390	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G6Z48_RS18395	COG1473	amidohydrolase
G6Z48_RS18400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS18405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z48_RS18410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z48_RS18415	COG1289	transmembrane transporter activity
G6Z48_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS18425	COG2814	Major facilitator Superfamily
G6Z48_RS18455	COG0316	Belongs to the HesB IscA family
G6Z48_RS18480	COG0784	Response regulator, receiver
G6Z48_RS18480	COG2205	protein histidine kinase activity
G6Z48_RS18480	COG5002	protein histidine kinase activity
G6Z48_RS18495	COG1051	belongs to the nudix hydrolase family
G6Z48_RS18510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G6Z48_RS18515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G6Z48_RS18520	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G6Z48_RS18530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G6Z48_RS18535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G6Z48_RS18540	COG0730	response to heat
G6Z48_RS18550	COG0134	indole-3-glycerol-phosphate synthase activity
G6Z48_RS18555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G6Z48_RS18575	COG1597	lipid kinase activity
G6Z48_RS18590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G6Z48_RS18595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G6Z48_RS18605	COG2111	Na H antiporter
G6Z48_RS18605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G6Z48_RS18610	COG1006	Multisubunit Na H antiporter MnhC subunit
G6Z48_RS18615	COG0651	ATP synthesis coupled electron transport
G6Z48_RS18620	COG1863	multisubunit Na H antiporter MnhE subunit
G6Z48_RS18625	COG2212	antiporter activity
G6Z48_RS18630	COG1320	monovalent cation:proton antiporter activity
G6Z48_RS18635	COG0530	calcium, potassium:sodium antiporter activity
G6Z48_RS18650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G6Z48_RS18665	COG4804	nuclease activity
G6Z48_RS18680	COG3104	oligopeptide transport
G6Z48_RS18685	COG3483	tryptophan 2,3-dioxygenase activity
G6Z48_RS18715	COG2378	regulation of single-species biofilm formation
G6Z48_RS18730	COG2354	Protein conserved in bacteria
G6Z48_RS18735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G6Z48_RS18740	COG1368	sulfuric ester hydrolase activity
G6Z48_RS18745	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
G6Z48_RS18745	COG3264	Mechanosensitive ion channel
G6Z48_RS18750	COG3415	Transposase
G6Z48_RS18750	COG2801	Transposase and inactivated derivatives
G6Z48_RS18765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G6Z48_RS18785	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS18805	COG1166	arginine decarboxylase activity
G6Z48_RS18810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G6Z48_RS18830	COG2960	long-chain fatty acid transporting porin activity
G6Z48_RS18905	COG0606	chelatase, subunit chli
G6Z48_RS18915	COG2801	Transposase and inactivated derivatives
G6Z48_RS18915	COG3415	Transposase
G6Z48_RS18935	COG0561	phosphatase activity
G6Z48_RS18940	COG3932	Exopolysaccharide synthesis, ExoD
G6Z48_RS18970	COG1999	signal sequence binding
G6Z48_RS18975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G6Z48_RS18980	COG1845	cytochrome c oxidase, subunit III
G6Z48_RS18990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G6Z48_RS18995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z48_RS19010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z48_RS19015	COG1104	cysteine desulfurase activity
G6Z48_RS19070	COG2031	fatty acid transporter
G6Z48_RS19115	COG0673	inositol 2-dehydrogenase activity
G6Z48_RS19125	COG1501	Belongs to the glycosyl hydrolase 31 family
G6Z48_RS19130	COG2222	sugar isomerase
G6Z48_RS19135	COG1940	carbohydrate kinase activity
G6Z48_RS19145	COG1349	DNA-binding transcription factor activity
G6Z48_RS19150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G6Z48_RS19155	COG2814	Major facilitator Superfamily
G6Z48_RS19190	COG1040	competence protein
G6Z48_RS19210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G6Z48_RS19215	COG0156	8-amino-7-oxononanoate synthase activity
G6Z48_RS19220	COG2267	carboxylic ester hydrolase activity
G6Z48_RS19260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6Z48_RS19265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6Z48_RS19270	COG2205	protein histidine kinase activity
G6Z48_RS19275	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS19280	COG3541	Predicted nucleotidyltransferase
G6Z48_RS19285	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G6Z48_RS19310	COG0714	Associated with various cellular activities
G6Z48_RS19325	COG0754	glutathionylspermidine amidase activity
G6Z48_RS19335	COG0129	dihydroxy-acid dehydratase activity
G6Z48_RS19340	COG1199	ATP-dependent helicase activity
G6Z48_RS19350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G6Z48_RS19370	COG3781	membrane
G6Z48_RS19400	COG0625	glutathione transferase activity
G6Z48_RS19420	COG2207	Transcriptional regulator
G6Z48_RS19435	COG4555	ABC transporter
G6Z48_RS19465	COG0543	2 iron, 2 sulfur cluster binding
G6Z48_RS19465	COG0633	Ferredoxin
G6Z48_RS19470	COG1131	(ABC) transporter
G6Z48_RS19475	COG0842	Transport permease protein
G6Z48_RS19485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G6Z48_RS19495	COG0084	hydrolase, TatD family'
G6Z48_RS19500	COG1643	Atp-dependent helicase
G6Z48_RS19510	COG1187	pseudouridine synthase activity
G6Z48_RS19525	COG0667	Aldo Keto reductase
G6Z48_RS19540	COG1690	Belongs to the RtcB family
G6Z48_RS19555	COG0840	transmembrane signaling receptor activity
G6Z48_RS19560	COG0583	DNA-binding transcription factor activity
G6Z48_RS19565	COG2814	Major facilitator Superfamily
G6Z48_RS19575	COG2267	carboxylic ester hydrolase activity
G6Z48_RS19580	COG0393	Putative heavy-metal-binding
G6Z48_RS19585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G6Z48_RS19585	COG0045	succinate-CoA ligase (ADP-forming) activity
G6Z48_RS19585	COG1042	CoA-binding domain protein
G6Z48_RS19590	COG2239	Acts as a magnesium transporter
G6Z48_RS19600	COG0666	response to abiotic stimulus
G6Z48_RS19600	COG3177	Filamentation induced by cAMP protein fic
G6Z48_RS19605	COG3100	YcgL domain-containing protein
G6Z48_RS19615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G6Z48_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS19660	COG2986	histidine ammonia-lyase
G6Z48_RS19670	COG0463	Glycosyl transferase, family 2
G6Z48_RS19685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G6Z48_RS19690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G6Z48_RS19705	COG1294	oxidase, subunit
G6Z48_RS19710	COG1271	oxidase subunit
G6Z48_RS19720	COG1595	DNA-templated transcription, initiation
G6Z48_RS19755	COG0408	coproporphyrinogen oxidase activity
G6Z48_RS19765	COG2323	membrane
G6Z48_RS19780	COG0589	response to stress
G6Z48_RS19805	COG0210	DNA helicase
G6Z48_RS19815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6Z48_RS19820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G6Z48_RS19825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G6Z48_RS19830	COG1819	glycosyl
G6Z48_RS19845	COG0251	oxidation-reduction process
G6Z48_RS19880	COG0463	Glycosyl transferase, family 2
G6Z48_RS19895	COG1475	DNA binding
G6Z48_RS19900	COG1192	Involved in chromosome partitioning
G6Z48_RS19905	COG0357	Ribosomal RNA small subunit methyltransferase G
G6Z48_RS19910	COG2091	lysine biosynthetic process via aminoadipic acid
G6Z48_RS19950	COG1971	Probably functions as a manganese efflux pump
G6Z48_RS19955	COG0784	Response regulator, receiver
G6Z48_RS19955	COG2205	protein histidine kinase activity
G6Z48_RS19965	COG0443	Heat shock 70 kDa protein
G6Z48_RS19975	COG2911	Protein conserved in bacteria
G6Z48_RS19980	COG0729	surface antigen
G6Z48_RS19990	COG0752	glycyl-tRNA synthetase alpha subunit
G6Z48_RS20000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G6Z48_RS20000	COG0519	Catalyzes the synthesis of GMP from XMP
G6Z48_RS20010	COG0805	protein transport
G6Z48_RS20020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G6Z48_RS20030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G6Z48_RS20040	COG0840	transmembrane signaling receptor activity
G6Z48_RS20095	COG3135	benzoate transporter
G6Z48_RS20110	COG2951	lytic endotransglycosylase activity
G6Z48_RS20115	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
G6Z48_RS20120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G6Z48_RS20125	COG3706	GGDEF domain
G6Z48_RS20155	COG0302	gtp cyclohydrolase
G6Z48_RS20170	COG1566	PFAM secretion protein HlyD family protein
G6Z48_RS20180	COG1289	transmembrane transporter activity
G6Z48_RS20195	COG1074	ATP-dependent DNA helicase activity
G6Z48_RS20200	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G6Z48_RS20205	COG1127	ABC transporter
G6Z48_RS20210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G6Z48_RS20215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G6Z48_RS20230	COG2853	Lipoprotein
G6Z48_RS20235	COG0386	Belongs to the glutathione peroxidase family
G6Z48_RS20245	COG1322	Protein conserved in bacteria
G6Z48_RS20255	COG0604	alcohol dehydrogenase
G6Z48_RS20260	COG0583	DNA-binding transcription factor activity
G6Z48_RS20280	COG0531	amino acid
G6Z48_RS20290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G6Z48_RS20295	COG0861	Integral membrane protein TerC family
G6Z48_RS20305	COG0584	glycerophosphoryl diester phosphodiesterase
G6Z48_RS20320	COG3415	Transposase
G6Z48_RS20320	COG2801	Transposase and inactivated derivatives
G6Z48_RS20325	COG0706	membrane insertase activity
G6Z48_RS20330	COG0594	ribonuclease P activity
G6Z48_RS20335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G6Z48_RS20340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G6Z48_RS20350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G6Z48_RS20355	COG0187	DNA topoisomerase II activity
G6Z48_RS20360	COG1266	CAAX protease self-immunity
G6Z48_RS20365	COG0501	Belongs to the peptidase M48B family
G6Z48_RS20445	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G6Z48_RS20455	COG4772	TonB-dependent receptor
G6Z48_RS20490	COG0800	Aldolase
G6Z48_RS20505	COG3186	Phenylalanine-4-hydroxylase
G6Z48_RS20510	COG1522	sequence-specific DNA binding
G6Z48_RS20515	COG1752	Esterase of the alpha-beta hydrolase superfamily
G6Z48_RS20525	COG4771	TonB-dependent receptor
G6Z48_RS20545	COG1119	ATPase activity
G6Z48_RS20560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G6Z48_RS20565	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G6Z48_RS20585	COG0210	DNA helicase
G6Z48_RS20595	COG3132	Protein of unknown function, DUF480
G6Z48_RS20600	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
G6Z48_RS20605	COG0284	orotidine-5'-phosphate decarboxylase activity
G6Z48_RS20615	COG2937	Belongs to the GPAT DAPAT family
G6Z48_RS20625	COG0037	tRNA processing
G6Z48_RS20630	COG2974	May be involved in recombination
G6Z48_RS20640	COG1803	Methylglyoxal synthase
G6Z48_RS20645	COG2205	protein histidine kinase activity
G6Z48_RS20645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z48_RS20650	COG0493	'glutamate synthase
G6Z48_RS20655	COG0067	glutamate synthase
G6Z48_RS20655	COG0069	glutamate synthase activity
G6Z48_RS20655	COG0070	glutamate synthase
G6Z48_RS20675	COG1028	Short-chain dehydrogenase reductase Sdr
G6Z48_RS20690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G6Z48_RS20715	COG1205	dead DEAH box helicase
G6Z48_RS20715	COG1111	helicase
G6Z48_RS20750	COG0714	Associated with various cellular activities
G6Z48_RS20770	COG0312	modulator of DNA gyrase
G6Z48_RS20780	COG3550	peptidyl-serine autophosphorylation
G6Z48_RS20800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G6Z48_RS20820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6Z48_RS20845	COG1881	PFAM PEBP family protein
G6Z48_RS20860	COG1968	undecaprenyl-diphosphatase activity
G6Z48_RS20865	COG0174	glutamine synthetase
G6Z48_RS20870	COG0347	Belongs to the P(II) protein family
G6Z48_RS20875	COG0004	ammonium transporteR
G6Z48_RS20880	COG3023	N-Acetylmuramoyl-L-alanine amidase
G6Z48_RS20890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G6Z48_RS20905	COG3852	Histidine kinase
G6Z48_RS20910	COG2204	response regulator
G6Z48_RS20915	COG2032	superoxide dismutase activity
G6Z48_RS20920	COG2032	superoxide dismutase activity
G6Z48_RS20930	COG0183	Belongs to the thiolase family
G6Z48_RS20965	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G6Z48_RS20970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G6Z48_RS20990	COG0798	PFAM Bile acid sodium symporter
G6Z48_RS21005	COG0431	NADPH-dependent FMN reductase
G6Z48_RS21055	COG0798	PFAM Bile acid sodium symporter
G6Z48_RS21070	COG0431	NADPH-dependent FMN reductase
G6Z48_RS21080	COG5290	Psort location Cytoplasmic, score
G6Z48_RS21100	COG2837	iron assimilation
G6Z48_RS21140	COG2197	response regulator
G6Z48_RS21145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6Z48_RS21145	COG2205	protein histidine kinase activity
G6Z48_RS21150	COG3474	cytochrome
G6Z48_RS21160	COG1960	acyl-CoA dehydrogenase activity
G6Z48_RS21165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G6Z48_RS21175	COG0612	Peptidase, M16
G6Z48_RS21185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G6Z48_RS21190	COG0596	Alpha beta hydrolase
G6Z48_RS21200	COG0318	PFAM AMP-dependent synthetase and ligase
G6Z48_RS21205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6Z48_RS21215	COG1181	Belongs to the D-alanine--D-alanine ligase family
G6Z48_RS21225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G6Z48_RS21240	COG1215	transferase activity, transferring glycosyl groups
G6Z48_RS21245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G6Z48_RS21275	COG0339	signal peptide processing
G6Z48_RS21290	COG0681	Belongs to the peptidase S26 family
G6Z48_RS21295	COG2814	Major facilitator Superfamily
G6Z48_RS21300	COG3415	Transposase
G6Z48_RS21300	COG2801	Transposase and inactivated derivatives
G6Z48_RS21305	COG0583	DNA-binding transcription factor activity
G6Z48_RS21310	COG0583	DNA-binding transcription factor activity
G6Z48_RS21315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G6Z48_RS21320	COG2224	Isocitrate lyase
G6Z48_RS21325	COG3706	GGDEF domain
G6Z48_RS21350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G6Z48_RS21355	COG1960	acyl-CoA dehydrogenase activity
G6Z48_RS21375	COG0697	spore germination
G6Z48_RS21385	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G6Z48_RS21395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G6Z48_RS21410	COG1607	acyl-coa hydrolase
G6Z48_RS21420	COG1902	pentaerythritol trinitrate reductase activity
G6Z48_RS21435	COG1335	isochorismatase
G6Z48_RS21440	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G6Z48_RS21450	COG1056	cytidyltransferase-related domain
G6Z48_RS21450	COG1051	belongs to the nudix hydrolase family
G6Z48_RS21455	COG1752	Esterase of the alpha-beta hydrolase superfamily
G6Z48_RS21465	COG3800	Transcriptional regulator
G6Z48_RS21465	COG1396	sequence-specific DNA binding
G6Z48_RS21475	COG1960	acyl-CoA dehydrogenase activity
G6Z48_RS21480	COG1024	Enoyl-CoA hydratase
G6Z48_RS21485	COG1024	Enoyl-CoA hydratase
G6Z48_RS21495	COG1764	response to oxidative stress
G6Z48_RS21520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G6Z48_RS21530	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS21535	COG2205	protein histidine kinase activity
G6Z48_RS21540	COG3228	Belongs to the MtfA family
G6Z48_RS21550	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G6Z48_RS21550	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G6Z48_RS21555	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G6Z48_RS21570	COG3657	addiction module killer protein
G6Z48_RS21615	COG3237	CsbD-like
G6Z48_RS21625	COG0180	Tryptophanyl-tRNA synthetase
G6Z48_RS21650	COG0477	Major facilitator Superfamily
G6Z48_RS21655	COG0697	spore germination
G6Z48_RS21665	COG4206	TonB-dependent receptor
G6Z48_RS21670	COG0577	efflux transmembrane transporter activity
G6Z48_RS21670	COG1136	(ABC) transporter
G6Z48_RS21680	COG1136	(ABC) transporter
G6Z48_RS21700	COG4585	Histidine kinase
G6Z48_RS21705	COG2197	response regulator
G6Z48_RS21720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G6Z48_RS21735	COG0628	permease
G6Z48_RS21755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G6Z48_RS21770	COG5507	3-demethylubiquinone-9 3-methyltransferase
G6Z48_RS21785	COG2197	response regulator
G6Z48_RS21800	COG2814	Major facilitator Superfamily
G6Z48_RS21805	COG0583	DNA-binding transcription factor activity
G6Z48_RS21810	COG4807	Protein conserved in bacteria
G6Z48_RS21820	COG4221	oxidoreductase activity
G6Z48_RS21830	COG0018	arginyl-trna synthetase
G6Z48_RS21835	COG2003	Belongs to the UPF0758 family
G6Z48_RS21840	COG2197	response regulator
G6Z48_RS21845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G6Z48_RS21850	COG0756	dUTP diphosphatase activity
G6Z48_RS21865	COG2205	protein histidine kinase activity
G6Z48_RS21875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G6Z48_RS21880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G6Z48_RS21895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G6Z48_RS21900	COG0708	Exodeoxyribonuclease III
G6Z48_RS21905	COG2223	nitrite transmembrane transporter activity
G6Z48_RS21920	COG0739	heme binding
G6Z48_RS21925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G6Z48_RS21985	COG2234	aminopeptidase activity
G6Z48_RS21995	COG4942	peptidase
G6Z48_RS22000	COG0793	Belongs to the peptidase S41A family
G6Z48_RS22035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G6Z48_RS22080	COG0109	protoheme IX farnesyltransferase activity
G6Z48_RS22100	COG0358	DNA primase activity
G6Z48_RS22105	COG1295	ribonuclease BN
G6Z48_RS22120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G6Z48_RS22130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G6Z48_RS22135	COG0668	transmembrane transport
G6Z48_RS22150	COG2133	pyrroloquinoline quinone binding
G6Z48_RS22155	COG4682	membrane
G6Z48_RS22165	COG0531	amino acid
G6Z48_RS22175	COG1737	Transcriptional regulator
G6Z48_RS22180	COG4948	Mandelate Racemase Muconate Lactonizing
G6Z48_RS22200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G6Z48_RS22230	COG5383	Protein conserved in bacteria
G6Z48_RS22240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G6Z48_RS22245	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G6Z48_RS22275	COG0778	Nitroreductase
G6Z48_RS22280	COG2353	YceI-like domain
G6Z48_RS22295	COG2375	cellular response to nickel ion
G6Z48_RS22405	COG2267	carboxylic ester hydrolase activity
G6Z48_RS22460	COG2801	Transposase and inactivated derivatives
G6Z48_RS22460	COG3415	Transposase
G6Z48_RS22480	COG0583	DNA-binding transcription factor activity
G6Z48_RS22490	COG2814	Major facilitator Superfamily
G6Z48_RS22495	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G6Z48_RS22500	COG1113	amino acid transport
G6Z48_RS22505	COG0741	lytic transglycosylase activity
G6Z48_RS22530	COG2764	glyoxalase bleomycin resistance protein dioxygenase
G6Z48_RS22540	COG5507	3-demethylubiquinone-9 3-methyltransferase
G6Z48_RS22545	COG4941	Belongs to the sigma-70 factor family
G6Z48_RS22575	COG3275	phosphorelay sensor kinase activity
G6Z48_RS22580	COG3279	Response regulator of the LytR AlgR family
G6Z48_RS22600	COG1309	transcriptional regulator
G6Z48_RS22615	COG3590	peptidase
G6Z48_RS22620	COG5001	Diguanylate cyclase
G6Z48_RS22625	COG0583	DNA-binding transcription factor activity
G6Z48_RS22635	COG3384	dioxygenase
G6Z48_RS22640	COG0025	NhaP-type Na H and K H
G6Z48_RS22665	COG1360	Flagellar Motor Protein
G6Z48_RS22695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6Z48_RS22710	COG5002	protein histidine kinase activity
G6Z48_RS22725	COG2813	Specifically methylates the guanine in position
G6Z48_RS22730	COG1187	pseudouridine synthase activity
G6Z48_RS22735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6Z48_RS22745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G6Z48_RS22750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G6Z48_RS22765	COG0583	DNA-binding transcription factor activity
G6Z48_RS22770	COG2226	methyltransferase
G6Z48_RS22795	COG1956	GAF domain-containing protein
G6Z48_RS22800	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G6Z48_RS22805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6Z48_RS22810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6Z48_RS22815	COG0785	Cytochrome C biogenesis protein
G6Z48_RS22815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6Z48_RS22820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6Z48_RS22825	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS22830	COG2205	protein histidine kinase activity
G6Z48_RS22835	COG2205	protein histidine kinase activity
G6Z48_RS22840	COG0745	RESPONSE REGULATOR receiver
G6Z48_RS22845	COG0367	asparagine synthase
G6Z48_RS22855	COG0720	synthase
G6Z48_RS22870	COG0513	Belongs to the DEAD box helicase family
G6Z48_RS22880	COG0625	glutathione transferase activity
G6Z48_RS22885	COG1573	uracil-dna glycosylase
G6Z48_RS22920	COG0626	cystathionine gamma-synthase activity
G6Z48_RS22935	COG0110	maltose O-acetyltransferase activity
G6Z48_RS22940	COG1216	Glycosyl transferase, family 2
G6Z48_RS22940	COG0438	transferase activity, transferring glycosyl groups
G6Z48_RS22945	COG3754	Rhamnan synthesis protein F
G6Z48_RS22955	COG2226	methyltransferase
G6Z48_RS22975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6Z48_RS22980	COG0300	oxidoreductase activity
G6Z48_RS22990	COG0546	phosphoglycolate phosphatase activity
G6Z48_RS22990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G6Z48_RS23005	COG2076	Multidrug Resistance protein
G6Z48_RS23080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G6Z48_RS23085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G6Z48_RS23120	COG1127	ABC transporter
G6Z48_RS23125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component