locus-tag	class	description
HGN30_RS00015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGN30_RS00020	COG0739	heme binding
HGN30_RS00035	COG2223	nitrite transmembrane transporter activity
HGN30_RS00040	COG0708	Exodeoxyribonuclease III
HGN30_RS00045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HGN30_RS00060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HGN30_RS00065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HGN30_RS00075	COG2205	protein histidine kinase activity
HGN30_RS00090	COG0756	dUTP diphosphatase activity
HGN30_RS00095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGN30_RS00100	COG2197	response regulator
HGN30_RS00105	COG2003	Belongs to the UPF0758 family
HGN30_RS00110	COG0018	arginyl-trna synthetase
HGN30_RS00120	COG4221	oxidoreductase activity
HGN30_RS00130	COG4807	Protein conserved in bacteria
HGN30_RS00135	COG0583	DNA-binding transcription factor activity
HGN30_RS00140	COG2814	Major facilitator Superfamily
HGN30_RS00155	COG2197	response regulator
HGN30_RS00170	COG5507	3-demethylubiquinone-9 3-methyltransferase
HGN30_RS00185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGN30_RS00205	COG0628	permease
HGN30_RS00220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGN30_RS00235	COG2197	response regulator
HGN30_RS00240	COG4585	Histidine kinase
HGN30_RS00260	COG1136	(ABC) transporter
HGN30_RS00270	COG0577	efflux transmembrane transporter activity
HGN30_RS00270	COG1136	(ABC) transporter
HGN30_RS00275	COG4206	TonB-dependent receptor
HGN30_RS00285	COG0697	spore germination
HGN30_RS00300	COG4152	abc transporter atp-binding protein
HGN30_RS00310	COG0477	Major facilitator Superfamily
HGN30_RS00335	COG0180	Tryptophanyl-tRNA synthetase
HGN30_RS00345	COG3237	CsbD-like
HGN30_RS00385	COG3657	addiction module killer protein
HGN30_RS00400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HGN30_RS00405	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HGN30_RS00405	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HGN30_RS00415	COG3228	Belongs to the MtfA family
HGN30_RS00420	COG2205	protein histidine kinase activity
HGN30_RS00425	COG0745	RESPONSE REGULATOR receiver
HGN30_RS00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGN30_RS00460	COG1764	response to oxidative stress
HGN30_RS00470	COG1024	Enoyl-CoA hydratase
HGN30_RS00475	COG1024	Enoyl-CoA hydratase
HGN30_RS00480	COG1960	acyl-CoA dehydrogenase activity
HGN30_RS00490	COG1396	sequence-specific DNA binding
HGN30_RS00490	COG3800	Transcriptional regulator
HGN30_RS00500	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGN30_RS00505	COG1051	belongs to the nudix hydrolase family
HGN30_RS00505	COG1056	cytidyltransferase-related domain
HGN30_RS00515	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HGN30_RS00520	COG1335	isochorismatase
HGN30_RS00535	COG1902	pentaerythritol trinitrate reductase activity
HGN30_RS00545	COG1607	acyl-coa hydrolase
HGN30_RS00550	COG1280	lysine exporter protein (LysE YggA)
HGN30_RS00560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGN30_RS00570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HGN30_RS00580	COG0697	spore germination
HGN30_RS00600	COG1960	acyl-CoA dehydrogenase activity
HGN30_RS00605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HGN30_RS00630	COG3706	GGDEF domain
HGN30_RS00635	COG2224	Isocitrate lyase
HGN30_RS00640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HGN30_RS00645	COG0583	DNA-binding transcription factor activity
HGN30_RS00650	COG0583	DNA-binding transcription factor activity
HGN30_RS00655	COG2814	Major facilitator Superfamily
HGN30_RS00660	COG0681	Belongs to the peptidase S26 family
HGN30_RS00675	COG0339	signal peptide processing
HGN30_RS00705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HGN30_RS00710	COG1215	transferase activity, transferring glycosyl groups
HGN30_RS00725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HGN30_RS00735	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGN30_RS00745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGN30_RS00750	COG0318	PFAM AMP-dependent synthetase and ligase
HGN30_RS00760	COG0596	Alpha beta hydrolase
HGN30_RS00765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGN30_RS00775	COG0612	Peptidase, M16
HGN30_RS00785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HGN30_RS00790	COG1960	acyl-CoA dehydrogenase activity
HGN30_RS00800	COG3474	cytochrome
HGN30_RS00805	COG2205	protein histidine kinase activity
HGN30_RS00805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGN30_RS00810	COG2197	response regulator
HGN30_RS00850	COG2837	iron assimilation
HGN30_RS00925	COG2814	Major facilitator Superfamily
HGN30_RS00970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGN30_RS00975	COG0210	DNA helicase
HGN30_RS01000	COG0431	NADPH-dependent FMN reductase
HGN30_RS01010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGN30_RS01015	COG0798	PFAM Bile acid sodium symporter
HGN30_RS01035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HGN30_RS01040	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HGN30_RS01075	COG0183	Belongs to the thiolase family
HGN30_RS01085	COG2032	superoxide dismutase activity
HGN30_RS01090	COG2032	superoxide dismutase activity
HGN30_RS01095	COG2204	response regulator
HGN30_RS01100	COG3852	Histidine kinase
HGN30_RS01115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HGN30_RS01125	COG0004	ammonium transporteR
HGN30_RS01130	COG0347	Belongs to the P(II) protein family
HGN30_RS01135	COG0174	glutamine synthetase
HGN30_RS01140	COG1968	undecaprenyl-diphosphatase activity
HGN30_RS01155	COG1881	PFAM PEBP family protein
HGN30_RS01180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGN30_RS01200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGN30_RS01220	COG3550	peptidyl-serine autophosphorylation
HGN30_RS01230	COG0312	modulator of DNA gyrase
HGN30_RS01250	COG0714	Associated with various cellular activities
HGN30_RS01285	COG1205	dead DEAH box helicase
HGN30_RS01285	COG1111	helicase
HGN30_RS01310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGN30_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS01345	COG0069	glutamate synthase activity
HGN30_RS01345	COG0067	glutamate synthase
HGN30_RS01345	COG0070	glutamate synthase
HGN30_RS01350	COG0493	'glutamate synthase
HGN30_RS01355	COG2205	protein histidine kinase activity
HGN30_RS01355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGN30_RS01360	COG1803	Methylglyoxal synthase
HGN30_RS01370	COG2974	May be involved in recombination
HGN30_RS01375	COG0037	tRNA processing
HGN30_RS01385	COG2937	Belongs to the GPAT DAPAT family
HGN30_RS01395	COG0284	orotidine-5'-phosphate decarboxylase activity
HGN30_RS01400	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HGN30_RS01405	COG3132	Protein of unknown function, DUF480
HGN30_RS01415	COG0210	DNA helicase
HGN30_RS01435	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HGN30_RS01440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HGN30_RS01455	COG1119	ATPase activity
HGN30_RS01485	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGN30_RS01490	COG1522	sequence-specific DNA binding
HGN30_RS01495	COG3186	Phenylalanine-4-hydroxylase
HGN30_RS01510	COG0800	Aldolase
HGN30_RS01545	COG4772	TonB-dependent receptor
HGN30_RS01555	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HGN30_RS01630	COG0501	Belongs to the peptidase M48B family
HGN30_RS01635	COG1266	CAAX protease self-immunity
HGN30_RS01640	COG0187	DNA topoisomerase II activity
HGN30_RS01645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGN30_RS01655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGN30_RS01660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HGN30_RS01665	COG0594	ribonuclease P activity
HGN30_RS01670	COG0706	membrane insertase activity
HGN30_RS01685	COG0584	glycerophosphoryl diester phosphodiesterase
HGN30_RS01695	COG0861	Integral membrane protein TerC family
HGN30_RS01700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HGN30_RS01705	COG2378	regulation of single-species biofilm formation
HGN30_RS01720	COG0531	amino acid
HGN30_RS01740	COG0583	DNA-binding transcription factor activity
HGN30_RS01745	COG0604	alcohol dehydrogenase
HGN30_RS01755	COG1322	Protein conserved in bacteria
HGN30_RS01765	COG0386	Belongs to the glutathione peroxidase family
HGN30_RS01770	COG2853	Lipoprotein
HGN30_RS01785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HGN30_RS01790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HGN30_RS01795	COG1127	ABC transporter
HGN30_RS01800	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HGN30_RS01805	COG1074	ATP-dependent DNA helicase activity
HGN30_RS01820	COG1289	transmembrane transporter activity
HGN30_RS01830	COG1566	PFAM secretion protein HlyD family protein
HGN30_RS01845	COG0302	gtp cyclohydrolase
HGN30_RS01875	COG3706	GGDEF domain
HGN30_RS01880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HGN30_RS01885	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HGN30_RS01890	COG2951	lytic endotransglycosylase activity
HGN30_RS01905	COG3135	benzoate transporter
HGN30_RS01970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HGN30_RS01980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HGN30_RS01990	COG0805	protein transport
HGN30_RS02000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HGN30_RS02000	COG0519	Catalyzes the synthesis of GMP from XMP
HGN30_RS02010	COG0752	glycyl-tRNA synthetase alpha subunit
HGN30_RS02020	COG0729	surface antigen
HGN30_RS02025	COG2911	Protein conserved in bacteria
HGN30_RS02035	COG0443	Heat shock 70 kDa protein
HGN30_RS02045	COG2205	protein histidine kinase activity
HGN30_RS02045	COG0784	Response regulator, receiver
HGN30_RS02050	COG1971	Probably functions as a manganese efflux pump
HGN30_RS02090	COG2091	lysine biosynthetic process via aminoadipic acid
HGN30_RS02095	COG0357	Ribosomal RNA small subunit methyltransferase G
HGN30_RS02100	COG1192	Involved in chromosome partitioning
HGN30_RS02105	COG1475	DNA binding
HGN30_RS02120	COG0463	Glycosyl transferase, family 2
HGN30_RS02155	COG0251	oxidation-reduction process
HGN30_RS02170	COG1819	glycosyl
HGN30_RS02175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HGN30_RS02180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HGN30_RS02185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGN30_RS02195	COG0210	DNA helicase
HGN30_RS02215	COG0589	response to stress
HGN30_RS02240	COG2323	membrane
HGN30_RS02250	COG0408	coproporphyrinogen oxidase activity
HGN30_RS02290	COG1595	DNA-templated transcription, initiation
HGN30_RS02300	COG1271	oxidase subunit
HGN30_RS02305	COG1294	oxidase, subunit
HGN30_RS02320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGN30_RS02325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGN30_RS02340	COG0463	Glycosyl transferase, family 2
HGN30_RS02350	COG2986	histidine ammonia-lyase
HGN30_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS02395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGN30_RS02405	COG3100	YcgL domain-containing protein
HGN30_RS02410	COG0666	response to abiotic stimulus
HGN30_RS02410	COG3177	Filamentation induced by cAMP protein fic
HGN30_RS02420	COG2239	Acts as a magnesium transporter
HGN30_RS02425	COG0045	succinate-CoA ligase (ADP-forming) activity
HGN30_RS02425	COG1042	CoA-binding domain protein
HGN30_RS02425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGN30_RS02460	COG2267	carboxylic ester hydrolase activity
HGN30_RS02465	COG0656	L-ascorbic acid biosynthetic process
HGN30_RS02470	COG2814	Major facilitator Superfamily
HGN30_RS02475	COG0583	DNA-binding transcription factor activity
HGN30_RS02480	COG0840	transmembrane signaling receptor activity
HGN30_RS02495	COG1690	Belongs to the RtcB family
HGN30_RS02510	COG0667	Aldo Keto reductase
HGN30_RS02525	COG1187	pseudouridine synthase activity
HGN30_RS02535	COG1643	Atp-dependent helicase
HGN30_RS02540	COG0084	hydrolase, TatD family'
HGN30_RS02550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HGN30_RS02560	COG0842	Transport permease protein
HGN30_RS02565	COG1131	(ABC) transporter
HGN30_RS02570	COG0633	Ferredoxin
HGN30_RS02570	COG0543	2 iron, 2 sulfur cluster binding
HGN30_RS02600	COG4555	ABC transporter
HGN30_RS02615	COG2207	Transcriptional regulator
HGN30_RS02635	COG0625	glutathione transferase activity
HGN30_RS02665	COG3781	membrane
HGN30_RS02685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HGN30_RS02695	COG1199	ATP-dependent helicase activity
HGN30_RS02705	COG0129	dihydroxy-acid dehydratase activity
HGN30_RS02715	COG0754	glutathionylspermidine amidase activity
HGN30_RS02730	COG0714	Associated with various cellular activities
HGN30_RS02755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HGN30_RS02760	COG3541	Predicted nucleotidyltransferase
HGN30_RS02765	COG0745	RESPONSE REGULATOR receiver
HGN30_RS02770	COG2205	protein histidine kinase activity
HGN30_RS02775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS02780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGN30_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS02820	COG2267	carboxylic ester hydrolase activity
HGN30_RS02825	COG0156	8-amino-7-oxononanoate synthase activity
HGN30_RS02830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HGN30_RS02850	COG1040	competence protein
HGN30_RS02920	COG2814	Major facilitator Superfamily
HGN30_RS02925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HGN30_RS02930	COG1349	DNA-binding transcription factor activity
HGN30_RS02940	COG1940	carbohydrate kinase activity
HGN30_RS02945	COG2222	sugar isomerase
HGN30_RS02950	COG1501	Belongs to the glycosyl hydrolase 31 family
HGN30_RS02960	COG0673	inositol 2-dehydrogenase activity
HGN30_RS02995	COG2031	fatty acid transporter
HGN30_RS03050	COG1104	cysteine desulfurase activity
HGN30_RS03055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGN30_RS03070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGN30_RS03075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HGN30_RS03085	COG1845	cytochrome c oxidase, subunit III
HGN30_RS03090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HGN30_RS03095	COG1999	signal sequence binding
HGN30_RS03125	COG3932	Exopolysaccharide synthesis, ExoD
HGN30_RS03130	COG0561	phosphatase activity
HGN30_RS03160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS03195	COG0464	growth
HGN30_RS03240	COG0606	chelatase, subunit chli
HGN30_RS03300	COG2960	long-chain fatty acid transporting porin activity
HGN30_RS03325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HGN30_RS03330	COG1166	arginine decarboxylase activity
HGN30_RS03350	COG0745	RESPONSE REGULATOR receiver
HGN30_RS03370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HGN30_RS03390	COG3264	Mechanosensitive ion channel
HGN30_RS03390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HGN30_RS03395	COG1368	sulfuric ester hydrolase activity
HGN30_RS03400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HGN30_RS03405	COG2354	Protein conserved in bacteria
HGN30_RS03420	COG2378	regulation of single-species biofilm formation
HGN30_RS03455	COG3483	tryptophan 2,3-dioxygenase activity
HGN30_RS03460	COG3104	oligopeptide transport
HGN30_RS03485	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HGN30_RS03500	COG0530	calcium, potassium:sodium antiporter activity
HGN30_RS03505	COG1320	monovalent cation:proton antiporter activity
HGN30_RS03510	COG2212	antiporter activity
HGN30_RS03515	COG1863	multisubunit Na H antiporter MnhE subunit
HGN30_RS03520	COG0651	ATP synthesis coupled electron transport
HGN30_RS03525	COG1006	Multisubunit Na H antiporter MnhC subunit
HGN30_RS03530	COG2111	Na H antiporter
HGN30_RS03530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGN30_RS03540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HGN30_RS03545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HGN30_RS03560	COG1597	lipid kinase activity
HGN30_RS03580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HGN30_RS03585	COG0134	indole-3-glycerol-phosphate synthase activity
HGN30_RS03595	COG0730	response to heat
HGN30_RS03600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGN30_RS03605	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HGN30_RS03615	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HGN30_RS03620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGN30_RS03625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HGN30_RS03640	COG1051	belongs to the nudix hydrolase family
HGN30_RS03680	COG0316	Belongs to the HesB IscA family
HGN30_RS03710	COG2814	Major facilitator Superfamily
HGN30_RS03715	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS03720	COG1289	transmembrane transporter activity
HGN30_RS03725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGN30_RS03730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGN30_RS03735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS03740	COG1473	amidohydrolase
HGN30_RS03745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HGN30_RS03745	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HGN30_RS03750	COG1652	LysM domain
HGN30_RS03785	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HGN30_RS03795	COG3706	GGDEF domain
HGN30_RS03800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HGN30_RS03805	COG3118	belongs to the thioredoxin family
HGN30_RS03815	COG2884	Cell division ATP-binding protein ftsE
HGN30_RS03820	COG2177	Part of the ABC transporter FtsEX involved in
HGN30_RS03825	COG2201	protein-glutamate methylesterase activity
HGN30_RS03830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HGN30_RS03835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGN30_RS03850	COG0151	Belongs to the GarS family
HGN30_RS03855	COG0138	bifunctional purine biosynthesis protein purh
HGN30_RS03860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGN30_RS03865	COG2267	carboxylic ester hydrolase activity
HGN30_RS03870	COG0671	phosphoesterase, PA-phosphatase related
HGN30_RS03870	COG2453	phosphatase
HGN30_RS03880	COG0204	Acyl-transferase
HGN30_RS03885	COG4589	Belongs to the CDS family
HGN30_RS03890	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HGN30_RS03900	COG2264	protein methyltransferase activity
HGN30_RS03915	COG0439	Biotin carboxylase
HGN30_RS03920	COG0511	ligase activity, forming carbon-carbon bonds
HGN30_RS03925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HGN30_RS03935	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HGN30_RS03945	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGN30_RS03955	COG1686	Belongs to the peptidase S11 family
HGN30_RS03960	COG1785	Belongs to the alkaline phosphatase family
HGN30_RS03975	COG0583	DNA-binding transcription factor activity
HGN30_RS03995	COG4585	Histidine kinase
HGN30_RS04015	COG0840	transmembrane signaling receptor activity
HGN30_RS04025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGN30_RS04035	COG1324	tolerance protein
HGN30_RS04040	COG2356	endonuclease I
HGN30_RS04045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HGN30_RS04050	COG0459	protein refolding
HGN30_RS04070	COG0745	RESPONSE REGULATOR receiver
HGN30_RS04075	COG2205	protein histidine kinase activity
HGN30_RS04080	COG1846	Transcriptional regulator
HGN30_RS04100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGN30_RS04105	COG2860	membrane
HGN30_RS04125	COG1252	NADH dehydrogenase
HGN30_RS04135	COG0625	glutathione transferase activity
HGN30_RS04140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGN30_RS04155	COG0534	Mate efflux family protein
HGN30_RS04160	COG0616	signal peptide processing
HGN30_RS04170	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS04185	COG0009	L-threonylcarbamoyladenylate synthase
HGN30_RS04190	COG1754	DNA topoisomerase type I activity
HGN30_RS04190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGN30_RS04195	COG1714	RDD family
HGN30_RS04205	COG2922	Belongs to the Smg family
HGN30_RS04210	COG0758	DNA mediated transformation
HGN30_RS04220	COG0242	peptide deformylase activity
HGN30_RS04225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGN30_RS04230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGN30_RS04230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGN30_RS04270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGN30_RS04280	COG1490	D-aminoacyl-tRNA deacylase activity
HGN30_RS04285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGN30_RS04305	COG2259	Doxx family
HGN30_RS04320	COG0625	glutathione transferase activity
HGN30_RS04340	COG4206	TonB-dependent receptor
HGN30_RS04385	COG0477	Major facilitator Superfamily
HGN30_RS04415	COG4771	TonB-dependent receptor
HGN30_RS04425	COG0400	carboxylic ester hydrolase activity
HGN30_RS04430	COG2972	Histidine kinase
HGN30_RS04430	COG0745	RESPONSE REGULATOR receiver
HGN30_RS04440	COG0181	hydroxymethylbilane synthase activity
HGN30_RS04460	COG1464	Belongs to the NlpA lipoprotein family
HGN30_RS04465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGN30_RS04485	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGN30_RS04490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGN30_RS04505	COG0356	it plays a direct role in the translocation of protons across the membrane
HGN30_RS04515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HGN30_RS04520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGN30_RS04525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HGN30_RS04530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HGN30_RS04535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGN30_RS04540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HGN30_RS04550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGN30_RS04560	COG4191	Histidine kinase
HGN30_RS04565	COG2204	response regulator
HGN30_RS04575	COG0577	efflux transmembrane transporter activity
HGN30_RS04580	COG1136	(ABC) transporter
HGN30_RS04580	COG0577	efflux transmembrane transporter activity
HGN30_RS04585	COG1136	(ABC) transporter
HGN30_RS04595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGN30_RS04615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGN30_RS04625	COG0339	signal peptide processing
HGN30_RS04640	COG1666	GTP binding
HGN30_RS04645	COG0697	spore germination
HGN30_RS04670	COG1505	serine-type exopeptidase activity
HGN30_RS04685	COG2832	Protein of unknown function (DUF454)
HGN30_RS04695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HGN30_RS04710	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HGN30_RS04720	COG0673	inositol 2-dehydrogenase activity
HGN30_RS04735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGN30_RS04765	COG2226	methyltransferase
HGN30_RS04770	COG0308	aminopeptidase N
HGN30_RS04785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGN30_RS04790	COG1077	Cell shape determining protein MreB Mrl
HGN30_RS04795	COG1792	Involved in formation and maintenance of cell shape
HGN30_RS04810	COG0772	Belongs to the SEDS family
HGN30_RS04815	COG0772	Belongs to the SEDS family
HGN30_RS04820	COG2951	lytic endotransglycosylase activity
HGN30_RS04825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HGN30_RS04830	COG1686	Belongs to the peptidase S11 family
HGN30_RS04840	COG2921	Belongs to the UPF0250 family
HGN30_RS04850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HGN30_RS04870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HGN30_RS04875	COG0673	inositol 2-dehydrogenase activity
HGN30_RS04880	COG2823	Periplasmic or secreted lipoprotein
HGN30_RS04885	COG4251	negative regulation of phosphorylation
HGN30_RS04890	COG0784	Response regulator, receiver
HGN30_RS04895	COG4191	Histidine kinase
HGN30_RS04910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HGN30_RS04930	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HGN30_RS04940	COG0837	glucose binding
HGN30_RS04950	COG1609	Transcriptional regulator
HGN30_RS04955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGN30_RS04960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HGN30_RS04995	COG0617	tRNA 3'-terminal CCA addition
HGN30_RS05020	COG4773	Receptor
HGN30_RS05030	COG1522	sequence-specific DNA binding
HGN30_RS05045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGN30_RS05050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGN30_RS05060	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HGN30_RS05065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HGN30_RS05085	COG1064	alcohol dehydrogenase
HGN30_RS05090	COG0583	DNA-binding transcription factor activity
HGN30_RS05115	COG1902	pentaerythritol trinitrate reductase activity
HGN30_RS05130	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HGN30_RS05140	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HGN30_RS05145	COG2203	Gaf domain
HGN30_RS05145	COG4251	negative regulation of phosphorylation
HGN30_RS05145	COG3706	GGDEF domain
HGN30_RS05145	COG5001	Diguanylate cyclase
HGN30_RS05185	COG1307	EDD domain protein, DegV family
HGN30_RS05195	COG0804	urea catabolic process
HGN30_RS05200	COG1228	amidohydrolase
HGN30_RS05215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HGN30_RS05235	COG0436	Aminotransferase
HGN30_RS05240	COG1162	GTPase activity
HGN30_RS05260	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS05265	COG2851	Citrate transporter
HGN30_RS05280	COG0642	Histidine kinase
HGN30_RS05295	COG4191	Histidine kinase
HGN30_RS05305	COG1301	dicarboxylic acid transport
HGN30_RS05345	COG1560	Kdo2-lipid A biosynthetic process
HGN30_RS05350	COG1519	Transferase
HGN30_RS05355	COG0531	amino acid
HGN30_RS05360	COG1538	Outer membrane efflux protein
HGN30_RS05365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGN30_RS05375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS05380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGN30_RS05395	COG0473	3-isopropylmalate dehydrogenase activity
HGN30_RS05410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGN30_RS05415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HGN30_RS05435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HGN30_RS05440	COG0405	Gamma-glutamyltransferase
HGN30_RS05445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGN30_RS05450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HGN30_RS05460	COG0745	RESPONSE REGULATOR receiver
HGN30_RS05485	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HGN30_RS05520	COG2832	Protein of unknown function (DUF454)
HGN30_RS05530	COG0848	biopolymer transport protein
HGN30_RS05540	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HGN30_RS05560	COG0563	adenylate kinase activity
HGN30_RS05565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGN30_RS05575	COG0671	phosphoesterase, PA-phosphatase related
HGN30_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS05605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGN30_RS05610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGN30_RS05620	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HGN30_RS05625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGN30_RS05630	COG0352	thiamine-phosphate diphosphorylase activity
HGN30_RS05635	COG1773	rubredoxin
HGN30_RS05640	COG2912	Transglutaminase-like superfamily
HGN30_RS05650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGN30_RS05660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGN30_RS05680	COG3079	Belongs to the UPF0149 family
HGN30_RS05685	COG0006	proline dipeptidase activity
HGN30_RS05690	COG0006	proline dipeptidase activity
HGN30_RS05705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGN30_RS05715	COG0346	lactoylglutathione lyase activity
HGN30_RS05720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HGN30_RS05725	COG1561	YicC-like family, N-terminal region
HGN30_RS05730	COG0709	Synthesizes selenophosphate from selenide and ATP
HGN30_RS05740	COG3276	selenocysteine insertion sequence binding
HGN30_RS05745	COG1921	L-seryl-tRNASec selenium transferase activity
HGN30_RS05755	COG2864	formate dehydrogenase
HGN30_RS05760	COG0437	4 iron, 4 sulfur cluster binding
HGN30_RS05775	COG1758	RNA polymerase activity
HGN30_RS05780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGN30_RS05790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGN30_RS05800	COG0254	rRNA binding
HGN30_RS05850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HGN30_RS05880	COG0714	Associated with various cellular activities
HGN30_RS05910	COG1301	dicarboxylic acid transport
HGN30_RS05915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGN30_RS05960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGN30_RS05975	COG0126	phosphoglycerate kinase activity
HGN30_RS05985	COG0469	pyruvate kinase activity
HGN30_RS05990	COG3588	fructose-bisphosphate aldolase
HGN30_RS06000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HGN30_RS06025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS06030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGN30_RS06040	COG1115	amino acid carrier protein
HGN30_RS06045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGN30_RS06055	COG1970	mechanosensitive ion channel activity
HGN30_RS06075	COG3273	potassium ion transport
HGN30_RS06075	COG0471	metal ion transport
HGN30_RS06080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGN30_RS06085	COG2022	thiamine diphosphate biosynthetic process
HGN30_RS06095	COG3240	lipase activity
HGN30_RS06095	COG4625	pathogenesis
HGN30_RS06120	COG0189	ligase activity
HGN30_RS06135	COG0745	RESPONSE REGULATOR receiver
HGN30_RS06155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HGN30_RS06190	COG0045	succinate-CoA ligase (ADP-forming) activity
HGN30_RS06200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGN30_RS06200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HGN30_RS06210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGN30_RS06215	COG0564	pseudouridine synthase activity
HGN30_RS06230	COG3011	Protein conserved in bacteria
HGN30_RS06235	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HGN30_RS06240	COG3387	PFAM Glycoside hydrolase 15-related
HGN30_RS06265	COG0028	Belongs to the TPP enzyme family
HGN30_RS06290	COG0542	response to heat
HGN30_RS06300	COG2205	protein histidine kinase activity
HGN30_RS06305	COG0745	RESPONSE REGULATOR receiver
HGN30_RS06315	COG4651	solute:proton antiporter activity
HGN30_RS06315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGN30_RS06325	COG0488	(ABC) transporter
HGN30_RS06355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HGN30_RS06375	COG0217	transcriptional regulatory protein
HGN30_RS06380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HGN30_RS06385	COG0632	four-way junction helicase activity
HGN30_RS06395	COG2255	four-way junction helicase activity
HGN30_RS06400	COG0824	Thioesterase
HGN30_RS06405	COG0811	peptide transport
HGN30_RS06420	COG0823	Involved in the tonB-independent uptake of proteins
HGN30_RS06425	COG2885	chlorophyll binding
HGN30_RS06435	COG0602	queuosine metabolic process
HGN30_RS06440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HGN30_RS06505	COG0514	ATP-dependent DNA helicase (RecQ)
HGN30_RS06510	COG0783	Belongs to the Dps family
HGN30_RS06515	COG1643	Atp-dependent helicase
HGN30_RS06525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGN30_RS06540	COG1215	transferase activity, transferring glycosyl groups
HGN30_RS06545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGN30_RS06555	COG1199	ATP-dependent helicase activity
HGN30_RS06560	COG1214	PFAM Peptidase M22, glycoprotease
HGN30_RS06570	COG0189	ligase activity
HGN30_RS06585	COG0835	chemotaxis
HGN30_RS06590	COG0840	transmembrane signaling receptor activity
HGN30_RS06595	COG0784	Response regulator, receiver
HGN30_RS06595	COG2198	Histidine kinase
HGN30_RS06595	COG0643	Histidine kinase
HGN30_RS06610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGN30_RS06620	COG0494	nUDIX hydrolase
HGN30_RS06630	COG3956	TIGRFAM MazG family protein
HGN30_RS06635	COG1742	UPF0060 membrane protein
HGN30_RS06645	COG0330	HflC and HflK could
HGN30_RS06655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGN30_RS06660	COG0509	glycine decarboxylation via glycine cleavage system
HGN30_RS06670	COG0583	DNA-binding transcription factor activity
HGN30_RS06700	COG1960	acyl-CoA dehydrogenase activity
HGN30_RS06710	COG1309	transcriptional regulator
HGN30_RS06725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HGN30_RS06730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGN30_RS06735	COG0463	Glycosyl transferase, family 2
HGN30_RS06750	COG1272	protein, Hemolysin III
HGN30_RS06755	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HGN30_RS06760	COG0739	heme binding
HGN30_RS06765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGN30_RS06770	COG0626	cystathionine gamma-synthase activity
HGN30_RS06775	COG0460	homoserine dehydrogenase
HGN30_RS06775	COG0527	aspartate kinase activity
HGN30_RS06780	COG2267	carboxylic ester hydrolase activity
HGN30_RS06790	COG1760	l-serine dehydratase
HGN30_RS06805	COG3038	cytochrome b561
HGN30_RS06825	COG0477	Major facilitator Superfamily
HGN30_RS06845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HGN30_RS06860	COG0259	pyridoxamine-phosphate oxidase activity
HGN30_RS06880	COG3829	transcription factor binding
HGN30_RS06900	COG3609	addiction module antidote protein, CC2985 family
HGN30_RS06910	COG2828	Protein conserved in bacteria
HGN30_RS06915	COG2079	MmgE PrpD family protein
HGN30_RS06920	COG2373	Large extracellular alpha-helical protein
HGN30_RS06925	COG4953	penicillin-binding protein 1C
HGN30_RS06935	COG0678	peroxiredoxin activity
HGN30_RS06950	COG0604	alcohol dehydrogenase
HGN30_RS06955	COG0330	HflC and HflK could
HGN30_RS06960	COG0330	HflC and HflK could
HGN30_RS06970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HGN30_RS06980	COG0739	heme binding
HGN30_RS06985	COG1376	ErfK ybiS ycfS ynhG family protein
HGN30_RS07015	COG0753	catalase activity
HGN30_RS07020	COG1917	Cupin 2, conserved barrel domain protein
HGN30_RS07020	COG2207	Transcriptional regulator
HGN30_RS07025	COG1113	amino acid transport
HGN30_RS07035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGN30_RS07035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGN30_RS07040	COG2814	Major facilitator Superfamily
HGN30_RS07080	COG2205	protein histidine kinase activity
HGN30_RS07095	COG2879	small protein
HGN30_RS07100	COG1966	Carbon starvation protein
HGN30_RS07105	COG1741	Belongs to the pirin family
HGN30_RS07115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HGN30_RS07120	COG1741	Belongs to the pirin family
HGN30_RS07140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGN30_RS07145	COG0481	GTPase activity
HGN30_RS07150	COG0681	Belongs to the peptidase S26 family
HGN30_RS07165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HGN30_RS07170	COG1381	Involved in DNA repair and RecF pathway recombination
HGN30_RS07175	COG0745	RESPONSE REGULATOR receiver
HGN30_RS07180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGN30_RS07185	COG2954	triphosphatase activity
HGN30_RS07190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HGN30_RS07195	COG1472	Belongs to the glycosyl hydrolase 3 family
HGN30_RS07205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HGN30_RS07210	COG1278	Cold shock
HGN30_RS07215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGN30_RS07230	COG1201	RNA secondary structure unwinding
HGN30_RS07235	COG1793	dna ligase
HGN30_RS07245	COG1960	acyl-CoA dehydrogenase activity
HGN30_RS07260	COG0183	Belongs to the thiolase family
HGN30_RS07280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGN30_RS07290	COG1451	nucleotide metabolic process
HGN30_RS07295	COG3122	Protein conserved in bacteria
HGN30_RS07300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HGN30_RS07340	COG0443	Heat shock 70 kDa protein
HGN30_RS07345	COG2824	Alkylphosphonate utilization operon protein PhnA
HGN30_RS07375	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HGN30_RS07375	COG0392	lysyltransferase activity
HGN30_RS07380	COG0251	oxidation-reduction process
HGN30_RS07390	COG2878	Part of a membrane complex involved in electron transport
HGN30_RS07400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGN30_RS07400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGN30_RS07410	COG0346	lactoylglutathione lyase activity
HGN30_RS07415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGN30_RS07425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HGN30_RS07445	COG5001	Diguanylate cyclase
HGN30_RS07445	COG3706	GGDEF domain
HGN30_RS07445	COG4251	negative regulation of phosphorylation
HGN30_RS07445	COG2203	Gaf domain
HGN30_RS07455	COG3118	belongs to the thioredoxin family
HGN30_RS07465	COG0495	leucyl-tRNA aminoacylation
HGN30_RS07480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HGN30_RS07490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HGN30_RS07560	COG4974	Belongs to the 'phage' integrase family
HGN30_RS07580	COG2968	Membrane
HGN30_RS07590	COG1530	ribonuclease E activity
HGN30_RS07600	COG0312	modulator of DNA gyrase
HGN30_RS07605	COG3028	Belongs to the UPF0307 family
HGN30_RS07610	COG0312	modulator of DNA gyrase
HGN30_RS07620	COG0142	geranyltranstransferase activity
HGN30_RS07625	COG1722	exodeoxyribonuclease VII activity
HGN30_RS07645	COG1301	dicarboxylic acid transport
HGN30_RS07650	COG0791	NLP P60 protein
HGN30_RS07655	COG0791	NLP P60 protein
HGN30_RS07660	COG1047	Peptidyl-prolyl cis-trans
HGN30_RS07665	COG2311	Membrane
HGN30_RS07670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGN30_RS07680	COG0697	spore germination
HGN30_RS07715	COG3590	peptidase
HGN30_RS07725	COG4771	TonB-dependent receptor
HGN30_RS07730	COG4771	TonB-dependent receptor
HGN30_RS07735	COG0489	protein tyrosine kinase activity
HGN30_RS07740	COG0717	Belongs to the dCTP deaminase family
HGN30_RS07755	COG0412	Dienelactone hydrolase
HGN30_RS07760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGN30_RS07770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGN30_RS07775	COG0433	COG0433 Predicted ATPase
HGN30_RS07790	COG0688	phosphatidylethanolamine metabolic process
HGN30_RS07795	COG1999	signal sequence binding
HGN30_RS07800	COG2890	protein-(glutamine-N5) methyltransferase activity
HGN30_RS07805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HGN30_RS07815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HGN30_RS07830	COG0101	tRNA pseudouridine synthase activity
HGN30_RS07855	COG0133	tryptophan synthase activity
HGN30_RS07865	COG0159	tryptophan synthase activity
HGN30_RS07870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HGN30_RS07875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGN30_RS07880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGN30_RS07885	COG0726	polysaccharide deacetylase
HGN30_RS07890	COG0438	transferase activity, transferring glycosyl groups
HGN30_RS07895	COG3083	sulfuric ester hydrolase activity
HGN30_RS07905	COG0149	triose-phosphate isomerase activity
HGN30_RS07920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGN30_RS07925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGN30_RS07930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGN30_RS07935	COG0649	NAD binding
HGN30_RS07940	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HGN30_RS07955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HGN30_RS07960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGN30_RS07970	COG0713	ATP synthesis coupled electron transport
HGN30_RS07985	COG1007	ATP synthesis coupled electron transport
HGN30_RS08000	COG0779	Required for maturation of 30S ribosomal subunits
HGN30_RS08005	COG0195	Participates in both transcription termination and antitermination
HGN30_RS08010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HGN30_RS08015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGN30_RS08025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGN30_RS08030	COG1185	polyribonucleotide nucleotidyltransferase activity
HGN30_RS08065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGN30_RS08070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGN30_RS08075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HGN30_RS08080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HGN30_RS08085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HGN30_RS08090	COG0072	phenylalanine-tRNA ligase activity
HGN30_RS08090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGN30_RS08095	COG0776	regulation of translation
HGN30_RS08130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HGN30_RS08155	COG1794	racemase activity, acting on amino acids and derivatives
HGN30_RS08160	COG1280	lysine exporter protein (LysE YggA)
HGN30_RS08165	COG5487	UPF0391 membrane protein
HGN30_RS08170	COG2076	Multidrug Resistance protein
HGN30_RS08205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGN30_RS08215	COG1960	acyl-CoA dehydrogenase activity
HGN30_RS08240	COG2130	NADP-dependent
HGN30_RS08245	COG2169	Transcriptional regulator
HGN30_RS08245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGN30_RS08410	COG0305	Participates in initiation and elongation during chromosome replication
HGN30_RS08450	COG3179	chitinase
HGN30_RS08615	COG0582	viral genome integration into host DNA
HGN30_RS08640	COG1309	transcriptional regulator
HGN30_RS08645	COG4771	TonB-dependent receptor
HGN30_RS08665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HGN30_RS08675	COG1570	exodeoxyribonuclease VII activity
HGN30_RS08680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HGN30_RS08685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HGN30_RS08685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HGN30_RS08690	COG0802	atpase or kinase
HGN30_RS08695	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGN30_RS08700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGN30_RS08720	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS08730	COG0501	Belongs to the peptidase M48B family
HGN30_RS08750	COG3300	MHYT domain
HGN30_RS08750	COG5001	Diguanylate cyclase
HGN30_RS08755	COG1509	lysine 2,3-aminomutase activity
HGN30_RS08760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGN30_RS08765	COG0402	S-adenosylhomocysteine deaminase activity
HGN30_RS08770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGN30_RS08790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HGN30_RS08810	COG2166	iron-sulfur cluster assembly
HGN30_RS08825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HGN30_RS08830	COG0137	argininosuccinate synthase activity
HGN30_RS08835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGN30_RS08840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HGN30_RS08850	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HGN30_RS08855	COG0165	Argininosuccinate lyase
HGN30_RS08870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HGN30_RS08880	COG1215	transferase activity, transferring glycosyl groups
HGN30_RS08885	COG1649	PFAM Uncharacterised BCR, COG1649
HGN30_RS08885	COG0726	polysaccharide deacetylase
HGN30_RS08915	COG1294	oxidase, subunit
HGN30_RS08925	COG4988	ABC transporter
HGN30_RS08930	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HGN30_RS08940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HGN30_RS08950	COG3088	subunit of a heme lyase
HGN30_RS08950	COG4235	cytochrome complex assembly
HGN30_RS08965	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HGN30_RS08985	COG4133	protoheme IX ABC transporter activity
HGN30_RS08990	COG0436	Aminotransferase
HGN30_RS09010	COG2814	Major facilitator Superfamily
HGN30_RS09020	COG1187	pseudouridine synthase activity
HGN30_RS09025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGN30_RS09030	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGN30_RS09035	COG2350	Protein conserved in bacteria
HGN30_RS09040	COG0271	Belongs to the BolA IbaG family
HGN30_RS09065	COG1175	transmembrane transport
HGN30_RS09070	COG0395	ABC-type sugar transport system, permease component
HGN30_RS09085	COG1530	ribonuclease E activity
HGN30_RS09095	COG0428	transporter
HGN30_RS09105	COG2154	pterin-4-alpha-carbinolamine dehydratase
HGN30_RS09110	COG0316	Belongs to the HesB IscA family
HGN30_RS09110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HGN30_RS09125	COG4290	ribonuclease
HGN30_RS09130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HGN30_RS09140	COG3104	oligopeptide transport
HGN30_RS09145	COG0705	Rhomboid family
HGN30_RS09165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGN30_RS09170	COG0339	signal peptide processing
HGN30_RS09175	COG0386	Belongs to the glutathione peroxidase family
HGN30_RS09190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HGN30_RS09195	COG1595	DNA-templated transcription, initiation
HGN30_RS09210	COG0625	glutathione transferase activity
HGN30_RS09245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HGN30_RS09250	COG0084	hydrolase, TatD family'
HGN30_RS09270	COG0625	glutathione transferase activity
HGN30_RS09290	COG0305	Participates in initiation and elongation during chromosome replication
HGN30_RS09300	COG3540	Alkaline phosphatase
HGN30_RS09325	COG0567	Dehydrogenase, E1 component
HGN30_RS09335	COG2850	peptidyl-arginine hydroxylation
HGN30_RS09345	COG0114	fumarate hydratase activity
HGN30_RS09370	COG1131	(ABC) transporter
HGN30_RS09375	COG1725	Transcriptional regulator
HGN30_RS09385	COG0386	Belongs to the glutathione peroxidase family
HGN30_RS09400	COG2900	Belongs to the SlyX family
HGN30_RS09420	COG2226	methyltransferase
HGN30_RS09425	COG1960	acyl-CoA dehydrogenase activity
HGN30_RS09440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGN30_RS09445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS09455	COG2902	Dehydrogenase
HGN30_RS09480	COG2925	Exonuclease
HGN30_RS09485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGN30_RS09490	COG3844	kynureninase activity
HGN30_RS09500	COG0288	reversible hydration of carbon dioxide
HGN30_RS09520	COG0017	Asparaginyl-tRNA synthetase
HGN30_RS09525	COG0316	Belongs to the HesB IscA family
HGN30_RS09535	COG0360	Binds together with S18 to 16S ribosomal RNA
HGN30_RS09540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HGN30_RS09545	COG0359	binds to the 23S rRNA
HGN30_RS09560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGN30_RS09565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGN30_RS09575	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HGN30_RS09585	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HGN30_RS09595	COG4993	Dehydrogenase
HGN30_RS09660	COG0583	DNA-binding transcription factor activity
HGN30_RS09665	COG2957	Belongs to the agmatine deiminase family
HGN30_RS09700	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HGN30_RS09715	COG1228	amidohydrolase
HGN30_RS09760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HGN30_RS09765	COG1605	Chorismate mutase
HGN30_RS09765	COG0077	Prephenate dehydratase
HGN30_RS09770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HGN30_RS09785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGN30_RS09795	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HGN30_RS09800	COG0583	DNA-binding transcription factor activity
HGN30_RS09825	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HGN30_RS09825	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HGN30_RS09835	COG0210	DNA helicase
HGN30_RS09850	COG0604	alcohol dehydrogenase
HGN30_RS09855	COG1733	regulation of RNA biosynthetic process
HGN30_RS09875	COG4774	siderophore transport
HGN30_RS09890	COG4191	Histidine kinase
HGN30_RS09890	COG0784	Response regulator, receiver
HGN30_RS09925	COG0789	Transcriptional regulator
HGN30_RS09930	COG2814	Major facilitator Superfamily
HGN30_RS09945	COG3505	Type IV secretory pathway VirD4
HGN30_RS09955	COG3736	Type IV secretory pathway, component VirB8
HGN30_RS09965	COG2948	multi-organism process
HGN30_RS09985	COG3702	type iv secretory pathway
HGN30_RS10055	COG0456	acetyltransferase
HGN30_RS10060	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGN30_RS10065	COG1733	regulation of RNA biosynthetic process
HGN30_RS10075	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HGN30_RS10085	COG1902	pentaerythritol trinitrate reductase activity
HGN30_RS10090	COG0668	transmembrane transport
HGN30_RS10100	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HGN30_RS10120	COG0534	Mate efflux family protein
HGN30_RS10125	COG2226	methyltransferase
HGN30_RS10125	COG1073	alpha beta
HGN30_RS10140	COG3243	poly(R)-hydroxyalkanoic acid synthase
HGN30_RS10150	COG1983	PspC domain protein
HGN30_RS10165	COG2183	response to ionizing radiation
HGN30_RS10255	COG0789	Transcriptional regulator
HGN30_RS10265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGN30_RS10280	COG0531	amino acid
HGN30_RS10285	COG1982	Orn Lys Arg decarboxylase major
HGN30_RS10310	COG1629	transport
HGN30_RS10310	COG4206	TonB-dependent receptor
HGN30_RS10320	COG1595	DNA-templated transcription, initiation
HGN30_RS10335	COG0519	Catalyzes the synthesis of GMP from XMP
HGN30_RS10335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HGN30_RS10340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HGN30_RS10355	COG0587	DNA-directed DNA polymerase activity
HGN30_RS10410	COG2814	Major facilitator Superfamily
HGN30_RS10435	COG1285	pathogenesis
HGN30_RS10445	COG2186	Transcriptional regulator
HGN30_RS10450	COG1304	FMN binding
HGN30_RS10455	COG0277	FAD linked oxidase domain protein
HGN30_RS10495	COG3161	chorismate lyase activity
HGN30_RS10510	COG0583	DNA-binding transcription factor activity
HGN30_RS10520	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HGN30_RS10530	COG2814	Major facilitator Superfamily
HGN30_RS10535	COG2197	response regulator
HGN30_RS10540	COG3850	Histidine kinase
HGN30_RS10555	COG1335	isochorismatase
HGN30_RS10565	COG1228	amidohydrolase
HGN30_RS10575	COG2814	Major facilitator Superfamily
HGN30_RS10630	COG4964	Belongs to the GSP D family
HGN30_RS10675	COG2226	methyltransferase
HGN30_RS10695	COG4772	TonB-dependent receptor
HGN30_RS10705	COG0583	DNA-binding transcription factor activity
HGN30_RS10740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGN30_RS10750	COG0604	alcohol dehydrogenase
HGN30_RS10750	COG3321	synthase
HGN30_RS10750	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS10755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGN30_RS10760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGN30_RS10775	COG1914	H( )-stimulated, divalent metal cation uptake system
HGN30_RS10790	COG4771	TonB-dependent receptor
HGN30_RS10840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGN30_RS10845	COG2409	Drug exporters of the RND superfamily
HGN30_RS10860	COG1021	2,3-dihydroxybenzoate-AMP ligase
HGN30_RS10865	COG3433	isochorismatase activity
HGN30_RS10865	COG1535	isochorismatase
HGN30_RS10870	COG3433	isochorismatase activity
HGN30_RS10870	COG1535	isochorismatase
HGN30_RS10875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HGN30_RS10875	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HGN30_RS10880	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS10895	COG2885	chlorophyll binding
HGN30_RS10915	COG2194	sulfuric ester hydrolase activity
HGN30_RS10925	COG2205	protein histidine kinase activity
HGN30_RS10975	COG2207	Transcriptional regulator
HGN30_RS11010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HGN30_RS11015	COG0521	Mo-molybdopterin cofactor biosynthetic process
HGN30_RS11015	COG0315	cyclic pyranopterin monophosphate synthase activity
HGN30_RS11020	COG0303	'Molybdopterin
HGN30_RS11030	COG0314	molybdopterin synthase activity
HGN30_RS11035	COG0746	molybdenum cofactor guanylyltransferase activity
HGN30_RS11045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGN30_RS11050	COG0725	ABC transporter, periplasmic molybdate-binding protein
HGN30_RS11055	COG4149	molybdate abc transporter
HGN30_RS11060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HGN30_RS11065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HGN30_RS11070	COG0840	transmembrane signaling receptor activity
HGN30_RS11080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HGN30_RS11085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HGN30_RS11225	COG0811	peptide transport
HGN30_RS11255	COG1335	isochorismatase
HGN30_RS11260	COG1335	isochorismatase
HGN30_RS11305	COG3920	Histidine kinase
HGN30_RS11305	COG2202	Pas domain
HGN30_RS11325	COG0477	Major facilitator Superfamily
HGN30_RS11340	COG3537	Alpha-1,2-mannosidase
HGN30_RS11345	COG0642	Histidine kinase
HGN30_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS11375	COG0583	DNA-binding transcription factor activity
HGN30_RS11380	COG5002	protein histidine kinase activity
HGN30_RS11395	COG2372	response to copper ion
HGN30_RS11415	COG0656	L-ascorbic acid biosynthetic process
HGN30_RS11420	COG0583	DNA-binding transcription factor activity
HGN30_RS11435	COG1136	(ABC) transporter
HGN30_RS11485	COG0243	molybdopterin cofactor binding
HGN30_RS11540	COG4566	intracellular signal transduction
HGN30_RS11545	COG4191	Histidine kinase
HGN30_RS11550	COG1285	pathogenesis
HGN30_RS11555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HGN30_RS11585	COG5002	protein histidine kinase activity
HGN30_RS11590	COG0596	Alpha beta hydrolase
HGN30_RS11600	COG4774	siderophore transport
HGN30_RS11610	COG3214	Protein conserved in bacteria
HGN30_RS11620	COG2205	protein histidine kinase activity
HGN30_RS11625	COG0745	RESPONSE REGULATOR receiver
HGN30_RS11635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS11640	COG1136	(ABC) transporter
HGN30_RS11640	COG0577	efflux transmembrane transporter activity
HGN30_RS11650	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS11660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGN30_RS11665	COG0366	Alpha amylase catalytic
HGN30_RS11670	COG0708	Exodeoxyribonuclease III
HGN30_RS11745	COG2204	response regulator
HGN30_RS11770	COG0583	DNA-binding transcription factor activity
HGN30_RS11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGN30_RS11820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGN30_RS11830	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS11835	COG2271	Major facilitator Superfamily
HGN30_RS11855	COG2186	Transcriptional regulator
HGN30_RS11870	COG0318	PFAM AMP-dependent synthetase and ligase
HGN30_RS11880	COG0642	Histidine kinase
HGN30_RS11905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGN30_RS11935	COG0583	DNA-binding transcription factor activity
HGN30_RS11940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HGN30_RS11965	COG0583	DNA-binding transcription factor activity
HGN30_RS11970	COG2828	Protein conserved in bacteria
HGN30_RS11985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGN30_RS12000	COG1472	Belongs to the glycosyl hydrolase 3 family
HGN30_RS12005	COG1609	Transcriptional regulator
HGN30_RS12010	COG0738	Major facilitator superfamily
HGN30_RS12015	COG4771	TonB-dependent receptor
HGN30_RS12030	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HGN30_RS12035	COG1733	regulation of RNA biosynthetic process
HGN30_RS12050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HGN30_RS12050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HGN30_RS12055	COG1105	Belongs to the carbohydrate kinase PfkB family
HGN30_RS12060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGN30_RS12060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGN30_RS12065	COG1609	Transcriptional regulator
HGN30_RS12095	COG1063	alcohol dehydrogenase
HGN30_RS12115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGN30_RS12140	COG3685	Protein conserved in bacteria
HGN30_RS12145	COG3546	catalase activity
HGN30_RS12170	COG3685	Protein conserved in bacteria
HGN30_RS12215	COG0300	oxidoreductase activity
HGN30_RS12230	COG1309	transcriptional regulator
HGN30_RS12270	COG4221	oxidoreductase activity
HGN30_RS12315	COG2080	2 iron, 2 sulfur cluster binding
HGN30_RS12320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HGN30_RS12325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HGN30_RS12330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HGN30_RS12415	COG4644	lycopene metabolic process
HGN30_RS12460	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HGN30_RS12510	COG0789	Transcriptional regulator
HGN30_RS12515	COG2608	mercury ion transmembrane transporter activity
HGN30_RS12520	COG2608	mercury ion transmembrane transporter activity
HGN30_RS12555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HGN30_RS12605	COG0789	Transcriptional regulator
HGN30_RS12610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HGN30_RS12615	COG4644	lycopene metabolic process
HGN30_RS12660	COG2217	Heavy metal translocating P-type atpase
HGN30_RS12675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS12680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGN30_RS12695	COG0010	Belongs to the arginase family
HGN30_RS12750	COG2132	Multicopper oxidase
HGN30_RS12785	COG0494	nUDIX hydrolase
HGN30_RS12790	COG0459	protein refolding
HGN30_RS12795	COG1185	polyribonucleotide nucleotidyltransferase activity
HGN30_RS12805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGN30_RS12810	COG0589	response to stress
HGN30_RS12815	COG0659	secondary active sulfate transmembrane transporter activity
HGN30_RS12880	COG2205	protein histidine kinase activity
HGN30_RS12885	COG0454	-acetyltransferase
HGN30_RS12885	COG0456	acetyltransferase
HGN30_RS12895	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HGN30_RS12905	COG4251	negative regulation of phosphorylation
HGN30_RS12910	COG0784	Response regulator, receiver
HGN30_RS12930	COG1595	DNA-templated transcription, initiation
HGN30_RS12945	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HGN30_RS12955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGN30_RS12970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGN30_RS13000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGN30_RS13010	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HGN30_RS13015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGN30_RS13020	COG4558	Periplasmic binding protein
HGN30_RS13030	COG2819	hydrolase of the alpha beta superfamily
HGN30_RS13045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HGN30_RS13060	COG1674	ftsk spoiiie
HGN30_RS13065	COG0492	ferredoxin-NADP+ reductase activity
HGN30_RS13095	COG0542	response to heat
HGN30_RS13105	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGN30_RS13120	COG0482	sulfurtransferase activity
HGN30_RS13125	COG2915	High frequency lysogenization protein hflD homolog
HGN30_RS13160	COG5002	protein histidine kinase activity
HGN30_RS13180	COG0835	chemotaxis
HGN30_RS13180	COG0784	Response regulator, receiver
HGN30_RS13185	COG1815	bacterial-type flagellum-dependent cell motility
HGN30_RS13190	COG1558	bacterial-type flagellum-dependent cell motility
HGN30_RS13205	COG4787	bacterial-type flagellum-dependent cell motility
HGN30_RS13215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HGN30_RS13250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGN30_RS13255	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HGN30_RS13275	COG2197	response regulator
HGN30_RS13295	COG1677	Flagellar hook-basal body complex protein FliE
HGN30_RS13345	COG3190	flagellar
HGN30_RS13355	COG1987	bacterial-type flagellum assembly
HGN30_RS13375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGN30_RS13380	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGN30_RS13405	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HGN30_RS13410	COG0643	Histidine kinase
HGN30_RS13410	COG2198	Histidine kinase
HGN30_RS13410	COG0784	Response regulator, receiver
HGN30_RS13415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HGN30_RS13420	COG1360	Flagellar Motor Protein
HGN30_RS13430	COG0835	chemotaxis
HGN30_RS13440	COG0745	RESPONSE REGULATOR receiver
HGN30_RS13450	COG0840	transmembrane signaling receptor activity
HGN30_RS13455	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HGN30_RS13460	COG0835	chemotaxis
HGN30_RS13470	COG0840	transmembrane signaling receptor activity
HGN30_RS13475	COG0840	transmembrane signaling receptor activity
HGN30_RS13485	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HGN30_RS13535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGN30_RS13540	COG1309	transcriptional regulator
HGN30_RS13545	COG1012	belongs to the aldehyde dehydrogenase family
HGN30_RS13550	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HGN30_RS13555	COG0318	PFAM AMP-dependent synthetase and ligase
HGN30_RS13560	COG1024	Enoyl-CoA hydratase
HGN30_RS13585	COG1012	belongs to the aldehyde dehydrogenase family
HGN30_RS13600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HGN30_RS13605	COG3279	Response regulator of the LytR AlgR family
HGN30_RS13620	COG4676	Protein conserved in bacteria
HGN30_RS13625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGN30_RS13640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGN30_RS13645	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGN30_RS13650	COG0505	Belongs to the CarA family
HGN30_RS13655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HGN30_RS13670	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGN30_RS13715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGN30_RS13735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS13740	COG0745	RESPONSE REGULATOR receiver
HGN30_RS13745	COG2205	protein histidine kinase activity
HGN30_RS13760	COG0277	FAD linked oxidase domain protein
HGN30_RS13765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGN30_RS13775	COG0531	amino acid
HGN30_RS13780	COG0531	amino acid
HGN30_RS13795	COG0235	Class ii aldolase
HGN30_RS13800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HGN30_RS13805	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HGN30_RS13820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGN30_RS13830	COG1609	Transcriptional regulator
HGN30_RS13835	COG3537	Alpha-1,2-mannosidase
HGN30_RS13850	COG0789	Transcriptional regulator
HGN30_RS13855	COG2217	Heavy metal translocating P-type atpase
HGN30_RS13865	COG3142	Participates in the control of copper homeostasis
HGN30_RS13870	COG1446	asparaginase
HGN30_RS13890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HGN30_RS13890	COG0140	phosphoribosyl-ATP diphosphatase activity
HGN30_RS13895	COG0107	imidazoleglycerol-phosphate synthase activity
HGN30_RS13900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HGN30_RS13905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HGN30_RS13910	COG0131	Imidazoleglycerol-phosphate dehydratase
HGN30_RS13910	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HGN30_RS13915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGN30_RS13920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HGN30_RS13925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HGN30_RS13935	COG0124	histidyl-tRNA synthetase
HGN30_RS13940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGN30_RS13945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGN30_RS13950	COG0083	homoserine kinase activity
HGN30_RS13955	COG0527	aspartate kinase activity
HGN30_RS13955	COG0460	homoserine dehydrogenase
HGN30_RS13995	COG0640	Transcriptional regulator
HGN30_RS14000	COG0745	RESPONSE REGULATOR receiver
HGN30_RS14010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HGN30_RS14015	COG2205	protein histidine kinase activity
HGN30_RS14015	COG3437	response regulator, receiver
HGN30_RS14015	COG3850	Histidine kinase
HGN30_RS14015	COG4999	Histidine kinase
HGN30_RS14020	COG0784	Response regulator, receiver
HGN30_RS14020	COG4191	Histidine kinase
HGN30_RS14085	COG1266	CAAX protease self-immunity
HGN30_RS14175	COG0740	serine-type endopeptidase activity
HGN30_RS14180	COG4695	Portal protein
HGN30_RS14185	COG1802	Transcriptional regulator
HGN30_RS14185	COG4626	Terminase
HGN30_RS14345	COG1012	belongs to the aldehyde dehydrogenase family
HGN30_RS14350	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS14365	COG0167	dihydroorotate dehydrogenase activity
HGN30_RS14370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGN30_RS14375	COG0697	spore germination
HGN30_RS14390	COG1309	transcriptional regulator
HGN30_RS14410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGN30_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS14425	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HGN30_RS14460	COG1473	amidohydrolase
HGN30_RS14465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGN30_RS14470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGN30_RS14480	COG0431	NADPH-dependent FMN reductase
HGN30_RS14485	COG4206	TonB-dependent receptor
HGN30_RS14520	COG4716	Myosin-crossreactive antigen
HGN30_RS14535	COG0640	Transcriptional regulator
HGN30_RS14565	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS14595	COG0583	DNA-binding transcription factor activity
HGN30_RS14655	COG2948	multi-organism process
HGN30_RS14670	COG3846	protein secretion by the type IV secretion system
HGN30_RS14685	COG3451	type IV secretory pathway VirB4
HGN30_RS14700	COG4962	Type ii secretion system protein e
HGN30_RS14720	COG0583	DNA-binding transcription factor activity
HGN30_RS14740	COG1733	regulation of RNA biosynthetic process
HGN30_RS14755	COG1733	regulation of RNA biosynthetic process
HGN30_RS14765	COG4959	Type IV secretory pathway protease TraF
HGN30_RS14780	COG1192	Involved in chromosome partitioning
HGN30_RS14815	COG5489	Protein of unknown function (DUF736)
HGN30_RS14820	COG1475	DNA binding
HGN30_RS14870	COG0084	hydrolase, TatD family'
HGN30_RS14880	COG0582	viral genome integration into host DNA
HGN30_RS14885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HGN30_RS14885	COG0519	Catalyzes the synthesis of GMP from XMP
HGN30_RS14900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGN30_RS14900	COG0475	glutathione-regulated potassium exporter activity
HGN30_RS14905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGN30_RS14925	COG1160	GTP binding
HGN30_RS14930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGN30_RS14940	COG1426	Protein conserved in bacteria
HGN30_RS14940	COG1426	Protein conserved in bacteria
HGN30_RS14945	COG0859	PFAM glycosyl transferase family 9
HGN30_RS14945	COG0457	Tetratricopeptide repeat
HGN30_RS14950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HGN30_RS14955	COG0105	UTP biosynthetic process
HGN30_RS14965	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGN30_RS14965	COG1024	Enoyl-CoA hydratase
HGN30_RS14970	COG0183	Belongs to the thiolase family
HGN30_RS14975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGN30_RS14985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGN30_RS14990	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HGN30_RS15000	COG0776	regulation of translation
HGN30_RS15010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HGN30_RS15015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HGN30_RS15025	COG2957	Belongs to the agmatine deiminase family
HGN30_RS15030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGN30_RS15045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGN30_RS15075	COG0583	DNA-binding transcription factor activity
HGN30_RS15085	COG0513	Belongs to the DEAD box helicase family
HGN30_RS15090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGN30_RS15095	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HGN30_RS15100	COG0625	glutathione transferase activity
HGN30_RS15120	COG4681	YaeQ
HGN30_RS15125	COG2081	HI0933 family
HGN30_RS15135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HGN30_RS15140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGN30_RS15150	COG1862	Preprotein translocase
HGN30_RS15155	COG0343	queuine tRNA-ribosyltransferase activity
HGN30_RS15160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HGN30_RS15165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGN30_RS15195	COG1132	(ABC) transporter
HGN30_RS15205	COG1605	Chorismate mutase
HGN30_RS15205	COG0287	Prephenate dehydrogenase
HGN30_RS15215	COG2223	nitrite transmembrane transporter activity
HGN30_RS15220	COG2207	Transcriptional regulator
HGN30_RS15225	COG0484	heat shock protein binding
HGN30_RS15230	COG0443	Heat shock 70 kDa protein
HGN30_RS15235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HGN30_RS15240	COG1420	regulation of RNA biosynthetic process
HGN30_RS15245	COG0497	DNA recombination
HGN30_RS15250	COG0583	DNA-binding transcription factor activity
HGN30_RS15260	COG0735	belongs to the Fur family
HGN30_RS15265	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGN30_RS15270	COG2914	Belongs to the UPF0125 (RnfH) family
HGN30_RS15280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HGN30_RS15295	COG0582	viral genome integration into host DNA
HGN30_RS15310	COG2204	response regulator
HGN30_RS15410	COG0583	DNA-binding transcription factor activity
HGN30_RS15415	COG2885	chlorophyll binding
HGN30_RS15420	COG0415	Belongs to the DNA photolyase family
HGN30_RS15430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HGN30_RS15450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HGN30_RS15470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGN30_RS15475	COG0405	Gamma-glutamyltransferase
HGN30_RS15480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGN30_RS15490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HGN30_RS15495	COG0742	ribosomal rna small subunit methyltransferase
HGN30_RS15510	COG0552	protein localization to endoplasmic reticulum
HGN30_RS15520	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HGN30_RS15535	COG4591	ABC-type transport system involved in lipoprotein release permease component
HGN30_RS15555	COG1053	succinate dehydrogenase
HGN30_RS15560	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HGN30_RS15565	COG2009	succinate dehydrogenase
HGN30_RS15590	COG0837	glucose binding
HGN30_RS15600	COG0129	dihydroxy-acid dehydratase activity
HGN30_RS15605	COG0800	Aldolase
HGN30_RS15615	COG0671	phosphoesterase, PA-phosphatase related
HGN30_RS15620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HGN30_RS15630	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HGN30_RS15635	COG0166	Belongs to the GPI family
HGN30_RS15640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HGN30_RS15650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HGN30_RS15655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HGN30_RS15660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HGN30_RS15665	COG0617	tRNA 3'-terminal CCA addition
HGN30_RS15675	COG0477	Major facilitator Superfamily
HGN30_RS15680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HGN30_RS15690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGN30_RS15700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HGN30_RS15705	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HGN30_RS15720	COG0352	thiamine-phosphate diphosphorylase activity
HGN30_RS15720	COG0351	phosphomethylpyrimidine kinase
HGN30_RS15745	COG0583	DNA-binding transcription factor activity
HGN30_RS15750	COG1741	Belongs to the pirin family
HGN30_RS15765	COG2223	nitrite transmembrane transporter activity
HGN30_RS15780	COG3258	Cytochrome c
HGN30_RS15795	COG3540	Alkaline phosphatase
HGN30_RS15845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HGN30_RS15850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGN30_RS15855	COG2137	regulation of response to DNA damage stimulus
HGN30_RS15860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HGN30_RS15865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HGN30_RS15870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HGN30_RS15875	COG1546	Belongs to the CinA family
HGN30_RS15880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGN30_RS15885	COG1923	regulation of RNA biosynthetic process
HGN30_RS15890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGN30_RS15895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HGN30_RS15905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGN30_RS15910	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HGN30_RS15915	COG1534	Rna-binding protein
HGN30_RS15940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGN30_RS15945	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HGN30_RS15950	COG2840	Smr protein MutS2
HGN30_RS15960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HGN30_RS15965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HGN30_RS15970	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HGN30_RS15975	COG0148	phosphopyruvate hydratase activity
HGN30_RS15990	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HGN30_RS15995	COG0504	CTP synthase activity
HGN30_RS16010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGN30_RS16030	COG1253	flavin adenine dinucleotide binding
HGN30_RS16045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGN30_RS16075	COG0069	glutamate synthase activity
HGN30_RS16080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HGN30_RS16325	COG0305	Participates in initiation and elongation during chromosome replication
HGN30_RS16445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGN30_RS16460	COG0348	domain, Protein
HGN30_RS16480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGN30_RS16485	COG4977	sequence-specific DNA binding
HGN30_RS16485	COG1917	Cupin 2, conserved barrel domain protein
HGN30_RS16505	COG0583	DNA-binding transcription factor activity
HGN30_RS16530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGN30_RS16585	COG0577	efflux transmembrane transporter activity
HGN30_RS16585	COG1136	(ABC) transporter
HGN30_RS16620	COG0322	excinuclease ABC activity
HGN30_RS16630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGN30_RS16635	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HGN30_RS16640	COG1663	tetraacyldisaccharide 4'-kinase activity
HGN30_RS16655	COG0811	peptide transport
HGN30_RS16665	COG2205	protein histidine kinase activity
HGN30_RS16675	COG3713	MltA-interacting MipA family protein
HGN30_RS16715	COG0556	nucleotide-excision repair
HGN30_RS16730	COG4968	Prepilin-type N-terminal cleavage methylation domain
HGN30_RS16760	COG1611	Belongs to the LOG family
HGN30_RS16775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HGN30_RS16785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HGN30_RS16820	COG2969	positive regulation of protein catabolic process
HGN30_RS16825	COG0625	glutathione transferase activity
HGN30_RS16830	COG2857	Cytochrome c1
HGN30_RS16835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HGN30_RS16840	COG0723	plastoquinol--plastocyanin reductase activity
HGN30_RS16845	COG0741	lytic transglycosylase activity
HGN30_RS16860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGN30_RS16865	COG0842	Transport permease protein
HGN30_RS16870	COG1131	(ABC) transporter
HGN30_RS16880	COG1702	phosphate starvation-inducible protein PhoH
HGN30_RS16885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HGN30_RS16905	COG4535	Mg2 and Co2 transporter CorC
HGN30_RS16920	COG1012	belongs to the aldehyde dehydrogenase family
HGN30_RS16925	COG1177	transmembrane transport
HGN30_RS16930	COG1176	ABC-type spermidine putrescine transport system, permease component I
HGN30_RS16935	COG3842	ATPase activity
HGN30_RS16940	COG2072	flavoprotein involved in K transport
HGN30_RS16950	COG0174	glutamine synthetase
HGN30_RS16955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HGN30_RS16960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGN30_RS16980	COG2703	oxygen carrier activity
HGN30_RS16985	COG0477	Major facilitator Superfamily
HGN30_RS16995	COG1012	belongs to the aldehyde dehydrogenase family
HGN30_RS17010	COG2733	membrane
HGN30_RS17030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HGN30_RS17030	COG0116	Belongs to the methyltransferase superfamily
HGN30_RS17050	COG0494	nUDIX hydrolase
HGN30_RS17060	COG1024	Enoyl-CoA hydratase
HGN30_RS17070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGN30_RS17080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HGN30_RS17085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HGN30_RS17090	COG0573	inorganic phosphate transmembrane transporter activity
HGN30_RS17095	COG0581	inorganic phosphate transmembrane transporter activity
HGN30_RS17105	COG0704	Plays a role in the regulation of phosphate uptake
HGN30_RS17115	COG3220	belongs to the UPF0276 family
HGN30_RS17125	COG2259	Doxx family
HGN30_RS17130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGN30_RS17135	COG3706	GGDEF domain
HGN30_RS17145	COG0745	RESPONSE REGULATOR receiver
HGN30_RS17150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS17155	COG1136	(ABC) transporter
HGN30_RS17155	COG0577	efflux transmembrane transporter activity
HGN30_RS17160	COG1538	Outer membrane efflux protein
HGN30_RS17165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGN30_RS17175	COG0557	exoribonuclease II activity
HGN30_RS17205	COG0583	DNA-binding transcription factor activity
HGN30_RS17220	COG2814	Major facilitator Superfamily
HGN30_RS17225	COG1566	PFAM secretion protein HlyD family protein
HGN30_RS17260	COG0475	glutathione-regulated potassium exporter activity
HGN30_RS17265	COG0367	asparagine synthase
HGN30_RS17270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGN30_RS17275	COG1393	Belongs to the ArsC family
HGN30_RS17290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HGN30_RS17310	COG3188	usher protein
HGN30_RS17330	COG0052	Belongs to the universal ribosomal protein uS2 family
HGN30_RS17335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HGN30_RS17340	COG3706	GGDEF domain
HGN30_RS17345	COG0528	UMP kinase activity
HGN30_RS17350	COG0233	cytoplasmic translational termination
HGN30_RS17355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGN30_RS17360	COG0575	Belongs to the CDS family
HGN30_RS17365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HGN30_RS17370	COG0750	zinc metalloprotease
HGN30_RS17375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGN30_RS17380	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGN30_RS17390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGN30_RS17415	COG0825	malonyl-CoA metabolic process
HGN30_RS17440	COG1695	Transcriptional regulator
HGN30_RS17490	COG1132	(ABC) transporter
HGN30_RS17515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGN30_RS17520	COG3706	GGDEF domain
HGN30_RS17525	COG1187	pseudouridine synthase activity
HGN30_RS17535	COG5002	protein histidine kinase activity
HGN30_RS17535	COG5001	Diguanylate cyclase
HGN30_RS17575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGN30_RS17615	COG0735	belongs to the Fur family
HGN30_RS17620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGN30_RS17635	COG4452	Inner membrane protein CreD
HGN30_RS17640	COG2205	protein histidine kinase activity
HGN30_RS17645	COG0745	RESPONSE REGULATOR receiver
HGN30_RS17650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HGN30_RS17660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGN30_RS17680	COG3590	peptidase
HGN30_RS17685	COG0588	phosphoglycerate mutase activity
HGN30_RS17710	COG3706	GGDEF domain
HGN30_RS17715	COG2814	Major facilitator Superfamily
HGN30_RS17740	COG1647	Serine aminopeptidase, S33
HGN30_RS17790	COG0024	Methionine aminopeptidase
HGN30_RS17800	COG0739	heme binding
HGN30_RS17805	COG4771	TonB-dependent receptor
HGN30_RS17825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGN30_RS17845	COG0840	transmembrane signaling receptor activity
HGN30_RS17880	COG3210	domain, Protein
HGN30_RS17920	COG3210	domain, Protein
HGN30_RS17925	COG2831	hemolysin activation secretion protein
HGN30_RS17945	COG0753	catalase activity
HGN30_RS17965	COG0534	Mate efflux family protein
HGN30_RS17985	COG0335	large ribosomal subunit rRNA binding
HGN30_RS17990	COG0336	Belongs to the RNA methyltransferase TrmD family
HGN30_RS17995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGN30_RS18000	COG0228	four-way junction DNA binding
HGN30_RS18015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGN30_RS18035	COG0326	Molecular chaperone. Has ATPase activity
HGN30_RS18050	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HGN30_RS18055	COG1845	cytochrome c oxidase, subunit III
HGN30_RS18060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HGN30_RS18105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGN30_RS18125	COG4206	TonB-dependent receptor
HGN30_RS18150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HGN30_RS18160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGN30_RS18165	COG0196	riboflavin kinase activity
HGN30_RS18170	COG0728	peptidoglycan biosynthetic process
HGN30_RS18175	COG0268	Binds directly to 16S ribosomal RNA
HGN30_RS18180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HGN30_RS18185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HGN30_RS18190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGN30_RS18195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HGN30_RS18200	COG0824	Thioesterase
HGN30_RS18220	COG1946	Acyl-CoA thioesterase
HGN30_RS18230	COG1595	DNA-templated transcription, initiation
HGN30_RS18240	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HGN30_RS18250	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HGN30_RS18290	COG2197	response regulator
HGN30_RS18295	COG4585	Histidine kinase
HGN30_RS18310	COG2894	cell division
HGN30_RS18315	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HGN30_RS18330	COG0823	Involved in the tonB-independent uptake of proteins
HGN30_RS18330	COG1506	peptidase
HGN30_RS18335	COG1297	OPT oligopeptide transporter protein
HGN30_RS18350	COG3104	oligopeptide transport
HGN30_RS18375	COG0579	oxidoreductase
HGN30_RS18390	COG3052	prosthetic group binding
HGN30_RS18425	COG1802	Transcriptional regulator
HGN30_RS18440	COG0477	Major facilitator Superfamily
HGN30_RS18455	COG0745	RESPONSE REGULATOR receiver
HGN30_RS18470	COG2259	Doxx family
HGN30_RS18490	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HGN30_RS18495	COG1408	metallophosphoesterase
HGN30_RS18500	COG1253	flavin adenine dinucleotide binding
HGN30_RS18505	COG3655	Transcriptional regulator
HGN30_RS18520	COG0640	Transcriptional regulator
HGN30_RS18545	COG3706	GGDEF domain
HGN30_RS18560	COG1609	Transcriptional regulator
HGN30_RS18570	COG2211	Major facilitator Superfamily
HGN30_RS18575	COG0673	inositol 2-dehydrogenase activity
HGN30_RS18585	COG2010	Cytochrome c
HGN30_RS18610	COG0629	single-stranded DNA binding
HGN30_RS18620	COG1131	(ABC) transporter
HGN30_RS18655	COG2190	(PTS) system
HGN30_RS18655	COG2211	Major facilitator Superfamily
HGN30_RS18665	COG1082	Xylose isomerase domain protein TIM barrel
HGN30_RS18675	COG0366	Alpha amylase catalytic
HGN30_RS18680	COG0142	geranyltranstransferase activity
HGN30_RS18705	COG0527	aspartate kinase activity
HGN30_RS18710	COG0384	phenazine biosynthesis protein PhzF
HGN30_RS18715	COG0384	phenazine biosynthesis protein PhzF
HGN30_RS18720	COG1764	response to oxidative stress
HGN30_RS18745	COG0693	protein deglycase activity
HGN30_RS18755	COG1959	2 iron, 2 sulfur cluster binding
HGN30_RS18760	COG0719	Fe-S assembly protein
HGN30_RS18765	COG0396	ATPase activity
HGN30_RS18770	COG0719	Fe-S assembly protein
HGN30_RS18775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGN30_RS18790	COG2146	nitrite reductase [NAD(P)H] activity
HGN30_RS18800	COG4774	siderophore transport
HGN30_RS18810	COG3128	pkhd-type hydroxylase
HGN30_RS18820	COG4771	TonB-dependent receptor
HGN30_RS18840	COG1477	protein flavinylation
HGN30_RS18845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HGN30_RS18865	COG1555	photosystem II stabilization
HGN30_RS18875	COG2261	transglycosylase associated protein
HGN30_RS18880	COG3178	'Phosphotransferase
HGN30_RS18885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HGN30_RS18895	COG0628	permease
HGN30_RS18905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HGN30_RS18925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGN30_RS18945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HGN30_RS18960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HGN30_RS18975	COG1137	ATPase activity
HGN30_RS18985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HGN30_RS18990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGN30_RS18995	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HGN30_RS19000	COG1660	Displays ATPase and GTPase activities
HGN30_RS19015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGN30_RS19020	COG2239	Acts as a magnesium transporter
HGN30_RS19040	COG0540	Belongs to the ATCase OTCase family
HGN30_RS19045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGN30_RS19050	COG1678	Uncharacterized ACR, COG1678
HGN30_RS19055	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HGN30_RS19060	COG0519	Catalyzes the synthesis of GMP from XMP
HGN30_RS19080	COG0667	Aldo Keto reductase
HGN30_RS19100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HGN30_RS19110	COG0583	DNA-binding transcription factor activity
HGN30_RS19145	COG0477	Major facilitator Superfamily
HGN30_RS19150	COG0583	DNA-binding transcription factor activity
HGN30_RS19155	COG0697	spore germination
HGN30_RS19160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGN30_RS19165	COG0583	DNA-binding transcription factor activity
HGN30_RS19175	COG2226	methyltransferase
HGN30_RS19190	COG2223	nitrite transmembrane transporter activity
HGN30_RS19205	COG4774	siderophore transport
HGN30_RS19360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HGN30_RS19365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HGN30_RS19370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HGN30_RS19375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGN30_RS19385	COG1028	Short-chain dehydrogenase reductase Sdr
HGN30_RS19390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGN30_RS19400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGN30_RS19405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HGN30_RS19410	COG1399	metal-binding, possibly nucleic acid-binding protein
HGN30_RS19430	COG0714	Associated with various cellular activities
HGN30_RS19450	COG0537	adenosine 5'-monophosphoramidase activity
HGN30_RS19460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HGN30_RS19490	COG2076	Multidrug Resistance protein
HGN30_RS19505	COG1234	tRNA 3'-trailer cleavage
HGN30_RS19510	COG3642	lipopolysaccharide core region biosynthetic process
HGN30_RS19515	COG0859	PFAM glycosyl transferase family 9
HGN30_RS19535	COG0631	protein serine/threonine phosphatase activity
HGN30_RS19540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGN30_RS19545	COG0328	RNA-DNA hybrid ribonuclease activity
HGN30_RS19555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGN30_RS19560	COG3942	CHAP domain
HGN30_RS19560	COG1388	LysM domain
HGN30_RS19565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGN30_RS19605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGN30_RS19610	COG0740	serine-type endopeptidase activity
HGN30_RS19615	COG0544	peptidyl-prolyl cis-trans isomerase activity
HGN30_RS19680	COG0473	3-isopropylmalate dehydrogenase activity
HGN30_RS19695	COG4783	chaperone-mediated protein folding
HGN30_RS19710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HGN30_RS19715	COG0248	Ppx GppA phosphatase
HGN30_RS19730	COG0438	transferase activity, transferring glycosyl groups
HGN30_RS19740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGN30_RS19745	COG3291	Pkd domain containing protein
HGN30_RS19755	COG2833	Protein of unknown function (DUF455)
HGN30_RS19775	COG0285	dihydrofolate synthase activity
HGN30_RS19780	COG0406	alpha-ribazole phosphatase activity
HGN30_RS19790	COG1063	alcohol dehydrogenase
HGN30_RS19810	COG1187	pseudouridine synthase activity
HGN30_RS19825	COG0604	alcohol dehydrogenase
HGN30_RS19830	COG2364	Membrane
HGN30_RS19835	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGN30_RS19835	COG1902	pentaerythritol trinitrate reductase activity
HGN30_RS19845	COG0625	glutathione transferase activity
HGN30_RS19860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGN30_RS19865	COG0564	pseudouridine synthase activity
HGN30_RS19870	COG0039	L-malate dehydrogenase activity
HGN30_RS19875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGN30_RS19890	COG0154	amidase activity
HGN30_RS19900	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HGN30_RS19915	COG0203	ribosomal protein L17
HGN30_RS19920	COG0202	RNA polymerase activity
HGN30_RS19925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGN30_RS19930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HGN30_RS19935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGN30_RS19940	COG0201	protein transport
HGN30_RS19945	COG0200	Binds to the 23S rRNA
HGN30_RS19950	COG1841	ribosomal large subunit assembly
HGN30_RS19955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGN30_RS19960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HGN30_RS19965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGN30_RS19970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGN30_RS19975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HGN30_RS19980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HGN30_RS19985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HGN30_RS19990	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HGN30_RS19995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HGN30_RS20000	COG0255	Belongs to the universal ribosomal protein uL29 family
HGN30_RS20005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HGN30_RS20010	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HGN30_RS20015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HGN30_RS20020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HGN30_RS20025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HGN30_RS20030	COG0089	rRNA binding
HGN30_RS20035	COG0088	Forms part of the polypeptide exit tunnel
HGN30_RS20040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGN30_RS20045	COG0051	transcription antitermination factor activity, RNA binding
HGN30_RS20050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGN30_RS20055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGN30_RS20060	COG0049	tRNA binding
HGN30_RS20065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGN30_RS20070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGN30_RS20075	COG0085	RNA polymerase activity
HGN30_RS20080	COG0222	ribosome binding
HGN30_RS20085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGN30_RS20090	COG0081	regulation of translation
HGN30_RS20095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HGN30_RS20100	COG0250	Participates in transcription elongation, termination and antitermination
HGN30_RS20115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGN30_RS20140	COG4242	Belongs to the peptidase S51 family
HGN30_RS20145	COG4206	TonB-dependent receptor
HGN30_RS20150	COG0012	GTP binding
HGN30_RS20155	COG0193	aminoacyl-tRNA hydrolase activity
HGN30_RS20160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HGN30_RS20165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGN30_RS20175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HGN30_RS20190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HGN30_RS20195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGN30_RS20210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGN30_RS20215	COG1295	ribonuclease BN
HGN30_RS20235	COG1404	Belongs to the peptidase S8 family
HGN30_RS20240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGN30_RS20255	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HGN30_RS20280	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HGN30_RS20295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGN30_RS20295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGN30_RS20335	COG3634	alkyl hydroperoxide reductase activity
HGN30_RS20340	COG0583	DNA-binding transcription factor activity
HGN30_RS20345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGN30_RS20355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGN30_RS20365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGN30_RS20385	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HGN30_RS20390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HGN30_RS20395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGN30_RS20400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGN30_RS20410	COG2096	Adenosyltransferase
HGN30_RS20420	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HGN30_RS20425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGN30_RS20430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HGN30_RS20435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGN30_RS20440	COG2967	ApaG domain
HGN30_RS20445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HGN30_RS20450	COG3738	Protein conserved in bacteria
HGN30_RS20460	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HGN30_RS20465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HGN30_RS20480	COG1704	LemA family
HGN30_RS20485	COG2814	Major facilitator Superfamily
HGN30_RS20490	COG0861	Integral membrane protein TerC family
HGN30_RS20495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HGN30_RS20505	COG0642	Histidine kinase
HGN30_RS20520	COG4181	ATPase activity
HGN30_RS20525	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HGN30_RS20540	COG4771	TonB-dependent receptor
HGN30_RS20550	COG0667	Aldo Keto reductase
HGN30_RS20555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HGN30_RS20560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGN30_RS20580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGN30_RS20585	COG4106	trans-aconitate 2-methyltransferase activity
HGN30_RS20615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGN30_RS20620	COG1607	acyl-coa hydrolase
HGN30_RS20635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HGN30_RS20640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HGN30_RS20660	COG3279	Response regulator of the LytR AlgR family
HGN30_RS20665	COG3275	phosphorelay sensor kinase activity
HGN30_RS20675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HGN30_RS20685	COG0494	nUDIX hydrolase
HGN30_RS20690	COG0653	protein targeting
HGN30_RS20695	COG0739	heme binding
HGN30_RS20705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HGN30_RS20710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGN30_RS20720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HGN30_RS20725	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGN30_RS20730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGN30_RS20750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HGN30_RS20765	COG3116	cell division
HGN30_RS20770	COG0275	rRNA processing
HGN30_RS20775	COG2001	Belongs to the MraZ family
HGN30_RS20820	COG1988	membrane-bound metal-dependent
HGN30_RS20825	COG0277	FAD linked oxidase domain protein
HGN30_RS20830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HGN30_RS20830	COG2755	lipolytic protein G-D-S-L family
HGN30_RS20845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGN30_RS20850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HGN30_RS20880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGN30_RS20880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGN30_RS20885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGN30_RS20905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGN30_RS20915	COG0488	(ABC) transporter
HGN30_RS20920	COG2252	PERMEase
HGN30_RS20935	COG1215	transferase activity, transferring glycosyl groups
HGN30_RS20945	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HGN30_RS20965	COG3539	Fimbrial protein
HGN30_RS20975	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HGN30_RS20990	COG1450	Type ii and iii secretion system protein
HGN30_RS21005	COG3166	PFAM Fimbrial assembly family protein
HGN30_RS21010	COG3156	type II secretion system protein K
HGN30_RS21015	COG4795	General secretion pathway protein
HGN30_RS21020	COG2165	general secretion pathway protein
HGN30_RS21025	COG4970	Tfp pilus assembly protein FimT
HGN30_RS21030	COG2165	general secretion pathway protein
HGN30_RS21035	COG1459	type II secretion system
HGN30_RS21040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HGN30_RS21045	COG1404	Belongs to the peptidase S8 family
HGN30_RS21050	COG5295	Hep Hag repeat protein
HGN30_RS21055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGN30_RS21055	COG0047	phosphoribosylformylglycinamidine synthase activity
HGN30_RS21065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGN30_RS21070	COG4974	Belongs to the 'phage' integrase family
HGN30_RS21085	COG0795	lipopolysaccharide-transporting ATPase activity
HGN30_RS21095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGN30_RS21105	COG0525	valine-tRNA ligase activity
HGN30_RS21115	COG0456	acetyltransferase
HGN30_RS21125	COG1183	phosphatidylcholine synthase activity
HGN30_RS21135	COG0442	prolyl-tRNA aminoacylation
HGN30_RS21150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HGN30_RS21155	COG1127	ABC transporter
HGN30_RS21180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGN30_RS21215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGN30_RS21220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGN30_RS21260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HGN30_RS21270	COG0438	transferase activity, transferring glycosyl groups
HGN30_RS21285	COG0626	cystathionine gamma-synthase activity
HGN30_RS21320	COG1573	uracil-dna glycosylase
HGN30_RS21325	COG0625	glutathione transferase activity
HGN30_RS21335	COG0513	Belongs to the DEAD box helicase family
HGN30_RS21350	COG0720	synthase
HGN30_RS21360	COG0367	asparagine synthase
HGN30_RS21365	COG0745	RESPONSE REGULATOR receiver
HGN30_RS21370	COG2205	protein histidine kinase activity
HGN30_RS21375	COG2205	protein histidine kinase activity
HGN30_RS21380	COG0745	RESPONSE REGULATOR receiver
HGN30_RS21385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGN30_RS21390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGN30_RS21390	COG0785	Cytochrome C biogenesis protein
HGN30_RS21395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGN30_RS21400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGN30_RS21405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HGN30_RS21410	COG1956	GAF domain-containing protein
HGN30_RS21425	COG4206	TonB-dependent receptor
HGN30_RS21430	COG0546	phosphoglycolate phosphatase activity
HGN30_RS21435	COG2226	methyltransferase
HGN30_RS21440	COG0583	DNA-binding transcription factor activity
HGN30_RS21455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGN30_RS21460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGN30_RS21470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGN30_RS21475	COG1187	pseudouridine synthase activity
HGN30_RS21480	COG2813	Specifically methylates the guanine in position
HGN30_RS21495	COG5002	protein histidine kinase activity
HGN30_RS21510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGN30_RS21540	COG1360	Flagellar Motor Protein
HGN30_RS21565	COG0025	NhaP-type Na H and K H
HGN30_RS21570	COG3384	dioxygenase
HGN30_RS21580	COG0583	DNA-binding transcription factor activity
HGN30_RS21585	COG5001	Diguanylate cyclase
HGN30_RS21590	COG3590	peptidase
HGN30_RS21605	COG1309	transcriptional regulator
HGN30_RS21625	COG3279	Response regulator of the LytR AlgR family
HGN30_RS21630	COG3275	phosphorelay sensor kinase activity
HGN30_RS21660	COG4941	Belongs to the sigma-70 factor family
HGN30_RS21665	COG5507	3-demethylubiquinone-9 3-methyltransferase
HGN30_RS21675	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HGN30_RS21700	COG0741	lytic transglycosylase activity
HGN30_RS21705	COG1113	amino acid transport
HGN30_RS21710	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HGN30_RS21715	COG2814	Major facilitator Superfamily
HGN30_RS21725	COG0583	DNA-binding transcription factor activity
HGN30_RS21795	COG2267	carboxylic ester hydrolase activity
HGN30_RS21865	COG0270	DNA (cytosine-5-)-methyltransferase activity
HGN30_RS21920	COG2375	cellular response to nickel ion
HGN30_RS21935	COG2353	YceI-like domain
HGN30_RS21940	COG0778	Nitroreductase
HGN30_RS21970	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HGN30_RS21975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HGN30_RS21985	COG5383	Protein conserved in bacteria
HGN30_RS22015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGN30_RS22035	COG4948	Mandelate Racemase Muconate Lactonizing
HGN30_RS22040	COG1737	Transcriptional regulator
HGN30_RS22050	COG0531	amino acid
HGN30_RS22060	COG4682	membrane
HGN30_RS22065	COG2133	pyrroloquinoline quinone binding
HGN30_RS22080	COG0668	transmembrane transport
HGN30_RS22085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HGN30_RS22095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HGN30_RS22110	COG1295	ribonuclease BN
HGN30_RS22115	COG0358	DNA primase activity
HGN30_RS22135	COG0109	protoheme IX farnesyltransferase activity
HGN30_RS22180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HGN30_RS22205	COG2067	long-chain fatty acid transport protein
HGN30_RS22215	COG0793	Belongs to the peptidase S41A family
HGN30_RS22220	COG4942	peptidase
HGN30_RS22230	COG2234	aminopeptidase activity