locus-tag	class	description
SMAL_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMAL_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMAL_RS00020	COG0187	DNA topoisomerase II activity
SMAL_RS00025	COG1266	CAAX protease self-immunity
SMAL_RS00030	COG0501	Belongs to the peptidase M48B family
SMAL_RS00060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMAL_RS00100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMAL_RS00110	COG4772	TonB-dependent receptor
SMAL_RS00145	COG0800	Aldolase
SMAL_RS00160	COG3186	Phenylalanine-4-hydroxylase
SMAL_RS00165	COG1522	sequence-specific DNA binding
SMAL_RS00175	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMAL_RS00205	COG1122	ATPase activity
SMAL_RS00225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMAL_RS00230	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
SMAL_RS00235	COG1435	thymidine kinase activity
SMAL_RS00250	COG0210	DNA helicase
SMAL_RS00260	COG3132	Protein of unknown function, DUF480
SMAL_RS00265	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SMAL_RS00270	COG0284	orotidine-5'-phosphate decarboxylase activity
SMAL_RS00280	COG2937	Belongs to the GPAT DAPAT family
SMAL_RS00290	COG0037	tRNA processing
SMAL_RS00295	COG2974	May be involved in recombination
SMAL_RS00305	COG1803	Methylglyoxal synthase
SMAL_RS00315	COG0493	'glutamate synthase
SMAL_RS00320	COG0067	glutamate synthase
SMAL_RS00320	COG0069	glutamate synthase activity
SMAL_RS00320	COG0070	glutamate synthase
SMAL_RS00340	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS00355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMAL_RS00370	COG2814	Major facilitator Superfamily
SMAL_RS00400	COG1205	dead DEAH box helicase
SMAL_RS00400	COG1111	helicase
SMAL_RS00435	COG0714	Associated with various cellular activities
SMAL_RS00455	COG0312	modulator of DNA gyrase
SMAL_RS00465	COG3550	peptidyl-serine autophosphorylation
SMAL_RS00485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMAL_RS00505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMAL_RS00540	COG1968	undecaprenyl-diphosphatase activity
SMAL_RS00545	COG0174	glutamine synthetase
SMAL_RS00550	COG0347	Belongs to the P(II) protein family
SMAL_RS00555	COG0004	ammonium transporteR
SMAL_RS00560	COG2831	hemolysin activation secretion protein
SMAL_RS00565	COG3210	domain, Protein
SMAL_RS00565	COG3210	domain, Protein
SMAL_RS00580	COG3279	Response regulator of the LytR AlgR family
SMAL_RS00595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SMAL_RS00610	COG3852	Histidine kinase
SMAL_RS00615	COG2204	response regulator
SMAL_RS00620	COG2032	superoxide dismutase activity
SMAL_RS00625	COG2032	superoxide dismutase activity
SMAL_RS00640	COG0183	Belongs to the thiolase family
SMAL_RS00675	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SMAL_RS00680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMAL_RS00695	COG3550	peptidyl-serine autophosphorylation
SMAL_RS00735	COG2837	iron assimilation
SMAL_RS00780	COG2197	response regulator
SMAL_RS00785	COG2205	protein histidine kinase activity
SMAL_RS00785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMAL_RS00790	COG3474	cytochrome
SMAL_RS00800	COG1960	acyl-CoA dehydrogenase activity
SMAL_RS00805	COG0583	DNA-binding transcription factor activity
SMAL_RS00815	COG1942	4-Oxalocrotonate Tautomerase
SMAL_RS00820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SMAL_RS00830	COG0612	Peptidase, M16
SMAL_RS00840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMAL_RS00845	COG0596	Alpha beta hydrolase
SMAL_RS00855	COG0318	PFAM AMP-dependent synthetase and ligase
SMAL_RS00860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMAL_RS00870	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMAL_RS00880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMAL_RS00890	COG0564	pseudouridine synthase activity
SMAL_RS00925	COG0681	Belongs to the peptidase S26 family
SMAL_RS00930	COG2814	Major facilitator Superfamily
SMAL_RS00935	COG0583	DNA-binding transcription factor activity
SMAL_RS00940	COG0583	DNA-binding transcription factor activity
SMAL_RS00945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SMAL_RS00950	COG2224	Isocitrate lyase
SMAL_RS00955	COG3706	GGDEF domain
SMAL_RS00995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SMAL_RS01000	COG1960	acyl-CoA dehydrogenase activity
SMAL_RS01020	COG0697	spore germination
SMAL_RS01030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SMAL_RS01045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMAL_RS01050	COG1280	lysine exporter protein (LysE YggA)
SMAL_RS01055	COG1607	acyl-coa hydrolase
SMAL_RS01060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SMAL_RS01065	COG1902	pentaerythritol trinitrate reductase activity
SMAL_RS01080	COG1335	isochorismatase
SMAL_RS01085	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMAL_RS01090	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMAL_RS01100	COG3800	Transcriptional regulator
SMAL_RS01100	COG1396	sequence-specific DNA binding
SMAL_RS01110	COG1960	acyl-CoA dehydrogenase activity
SMAL_RS01115	COG1024	Enoyl-CoA hydratase
SMAL_RS01120	COG1024	Enoyl-CoA hydratase
SMAL_RS01130	COG1764	response to oxidative stress
SMAL_RS01140	COG0659	secondary active sulfate transmembrane transporter activity
SMAL_RS01145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMAL_RS01165	COG3228	Belongs to the MtfA family
SMAL_RS01175	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SMAL_RS01175	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SMAL_RS01180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SMAL_RS01195	COG3657	addiction module killer protein
SMAL_RS01220	COG3237	CsbD-like
SMAL_RS01230	COG0180	Tryptophanyl-tRNA synthetase
SMAL_RS01255	COG0477	Major facilitator Superfamily
SMAL_RS01260	COG0697	spore germination
SMAL_RS01275	COG1136	(ABC) transporter
SMAL_RS01275	COG0577	efflux transmembrane transporter activity
SMAL_RS01285	COG1136	(ABC) transporter
SMAL_RS01290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS01305	COG4585	Histidine kinase
SMAL_RS01310	COG2197	response regulator
SMAL_RS01325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMAL_RS01335	COG0628	permease
SMAL_RS01355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMAL_RS01370	COG5507	3-demethylubiquinone-9 3-methyltransferase
SMAL_RS01380	COG2197	response regulator
SMAL_RS01395	COG2814	Major facilitator Superfamily
SMAL_RS01400	COG0583	DNA-binding transcription factor activity
SMAL_RS01405	COG4807	Protein conserved in bacteria
SMAL_RS01410	COG4221	oxidoreductase activity
SMAL_RS01420	COG0018	arginyl-trna synthetase
SMAL_RS01425	COG2003	Belongs to the UPF0758 family
SMAL_RS01435	COG2197	response regulator
SMAL_RS01440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMAL_RS01460	COG2205	protein histidine kinase activity
SMAL_RS01470	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMAL_RS01475	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMAL_RS01490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMAL_RS01495	COG0708	Exodeoxyribonuclease III
SMAL_RS01500	COG2223	nitrite transmembrane transporter activity
SMAL_RS01515	COG0739	heme binding
SMAL_RS01580	COG2234	aminopeptidase activity
SMAL_RS01590	COG4942	peptidase
SMAL_RS01595	COG0793	Belongs to the peptidase S41A family
SMAL_RS01625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMAL_RS01630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMAL_RS01670	COG0109	protoheme IX farnesyltransferase activity
SMAL_RS01690	COG0358	DNA primase activity
SMAL_RS01695	COG1295	ribonuclease BN
SMAL_RS01710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMAL_RS01720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SMAL_RS01725	COG0668	transmembrane transport
SMAL_RS01740	COG2133	pyrroloquinoline quinone binding
SMAL_RS01745	COG4682	membrane
SMAL_RS01755	COG0531	amino acid
SMAL_RS01765	COG1737	Transcriptional regulator
SMAL_RS01770	COG4948	Mandelate Racemase Muconate Lactonizing
SMAL_RS01820	COG5383	Protein conserved in bacteria
SMAL_RS01830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SMAL_RS01835	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SMAL_RS01865	COG0778	Nitroreductase
SMAL_RS01870	COG2353	YceI-like domain
SMAL_RS01880	COG3415	Transposase
SMAL_RS01880	COG2801	Transposase and inactivated derivatives
SMAL_RS01890	COG2375	cellular response to nickel ion
SMAL_RS01955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMAL_RS02005	COG2267	carboxylic ester hydrolase activity
SMAL_RS02065	COG0488	(ABC) transporter
SMAL_RS02070	COG0583	DNA-binding transcription factor activity
SMAL_RS02080	COG2814	Major facilitator Superfamily
SMAL_RS02085	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SMAL_RS02090	COG1113	amino acid transport
SMAL_RS02095	COG0741	lytic transglycosylase activity
SMAL_RS02120	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SMAL_RS02130	COG5507	3-demethylubiquinone-9 3-methyltransferase
SMAL_RS02135	COG4941	Belongs to the sigma-70 factor family
SMAL_RS02165	COG3275	phosphorelay sensor kinase activity
SMAL_RS02170	COG3279	Response regulator of the LytR AlgR family
SMAL_RS02190	COG1309	transcriptional regulator
SMAL_RS02205	COG3590	peptidase
SMAL_RS02210	COG5001	Diguanylate cyclase
SMAL_RS02215	COG0583	DNA-binding transcription factor activity
SMAL_RS02225	COG3384	dioxygenase
SMAL_RS02230	COG0025	NhaP-type Na H and K H
SMAL_RS02285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMAL_RS02300	COG2205	protein histidine kinase activity
SMAL_RS02315	COG2813	Specifically methylates the guanine in position
SMAL_RS02320	COG1187	pseudouridine synthase activity
SMAL_RS02325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMAL_RS02335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMAL_RS02340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMAL_RS02355	COG0583	DNA-binding transcription factor activity
SMAL_RS02360	COG2226	methyltransferase
SMAL_RS02385	COG1956	GAF domain-containing protein
SMAL_RS02390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMAL_RS02395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMAL_RS02400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMAL_RS02405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMAL_RS02405	COG0785	Cytochrome C biogenesis protein
SMAL_RS02410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMAL_RS02415	COG0745	RESPONSE REGULATOR receiver
SMAL_RS02420	COG5002	protein histidine kinase activity
SMAL_RS02425	COG2205	protein histidine kinase activity
SMAL_RS02430	COG0745	RESPONSE REGULATOR receiver
SMAL_RS02435	COG0367	asparagine synthase
SMAL_RS02445	COG0720	synthase
SMAL_RS02465	COG0513	Belongs to the DEAD box helicase family
SMAL_RS02475	COG0625	glutathione transferase activity
SMAL_RS02505	COG0626	cystathionine gamma-synthase activity
SMAL_RS02530	COG1215	transferase activity, transferring glycosyl groups
SMAL_RS02550	COG0300	oxidoreductase activity
SMAL_RS02555	COG0277	FAD linked oxidase domain protein
SMAL_RS02560	COG0546	phosphoglycolate phosphatase activity
SMAL_RS02560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMAL_RS02595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMAL_RS02605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMAL_RS02610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMAL_RS02640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMAL_RS02675	COG1127	ABC transporter
SMAL_RS02680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMAL_RS02695	COG0442	prolyl-tRNA aminoacylation
SMAL_RS02705	COG1183	phosphatidylcholine synthase activity
SMAL_RS02715	COG0456	acetyltransferase
SMAL_RS02725	COG0525	valine-tRNA ligase activity
SMAL_RS02740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMAL_RS02750	COG0795	lipopolysaccharide-transporting ATPase activity
SMAL_RS02760	COG4974	Belongs to the 'phage' integrase family
SMAL_RS02765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMAL_RS02775	COG0047	phosphoribosylformylglycinamidine synthase activity
SMAL_RS02775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMAL_RS02780	COG5295	Hep Hag repeat protein
SMAL_RS02785	COG1404	Belongs to the peptidase S8 family
SMAL_RS02790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMAL_RS02795	COG1459	type II secretion system
SMAL_RS02800	COG2165	general secretion pathway protein
SMAL_RS02805	COG4970	Tfp pilus assembly protein FimT
SMAL_RS02810	COG2165	general secretion pathway protein
SMAL_RS02815	COG4795	General secretion pathway protein
SMAL_RS02820	COG3156	type II secretion system protein K
SMAL_RS02825	COG3166	PFAM Fimbrial assembly family protein
SMAL_RS02840	COG1450	Type ii and iii secretion system protein
SMAL_RS02865	COG3539	Fimbrial protein
SMAL_RS02885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMAL_RS02895	COG1215	transferase activity, transferring glycosyl groups
SMAL_RS02910	COG2252	PERMEase
SMAL_RS02915	COG0488	(ABC) transporter
SMAL_RS02925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMAL_RS02940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMAL_RS02945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMAL_RS02945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMAL_RS02975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMAL_RS02980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMAL_RS02995	COG0277	FAD linked oxidase domain protein
SMAL_RS03000	COG1988	membrane-bound metal-dependent
SMAL_RS03030	COG2001	Belongs to the MraZ family
SMAL_RS03035	COG0275	rRNA processing
SMAL_RS03040	COG3116	cell division
SMAL_RS03050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMAL_RS03055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMAL_RS03075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMAL_RS03080	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMAL_RS03085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SMAL_RS03095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMAL_RS03100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SMAL_RS03110	COG0739	heme binding
SMAL_RS03115	COG0653	protein targeting
SMAL_RS03120	COG0494	nUDIX hydrolase
SMAL_RS03130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMAL_RS03140	COG3275	phosphorelay sensor kinase activity
SMAL_RS03145	COG3279	Response regulator of the LytR AlgR family
SMAL_RS03155	COG5002	protein histidine kinase activity
SMAL_RS03155	COG3850	Histidine kinase
SMAL_RS03160	COG0745	RESPONSE REGULATOR receiver
SMAL_RS03185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMAL_RS03190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMAL_RS03200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMAL_RS03205	COG1607	acyl-coa hydrolase
SMAL_RS03210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMAL_RS03240	COG4106	trans-aconitate 2-methyltransferase activity
SMAL_RS03245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMAL_RS03265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMAL_RS03270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SMAL_RS03275	COG0667	Aldo Keto reductase
SMAL_RS03285	COG4771	TonB-dependent receptor
SMAL_RS03305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SMAL_RS03310	COG4181	ATPase activity
SMAL_RS03325	COG0642	Histidine kinase
SMAL_RS03335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMAL_RS03340	COG0861	Integral membrane protein TerC family
SMAL_RS03345	COG2814	Major facilitator Superfamily
SMAL_RS03350	COG1704	LemA family
SMAL_RS03365	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMAL_RS03370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMAL_RS03385	COG3738	Protein conserved in bacteria
SMAL_RS03390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SMAL_RS03395	COG2967	ApaG domain
SMAL_RS03400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMAL_RS03405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMAL_RS03410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMAL_RS03415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SMAL_RS03425	COG2096	Adenosyltransferase
SMAL_RS03435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMAL_RS03440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMAL_RS03445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMAL_RS03450	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
SMAL_RS03470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMAL_RS03480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMAL_RS03490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMAL_RS03495	COG0583	DNA-binding transcription factor activity
SMAL_RS03500	COG3634	alkyl hydroperoxide reductase activity
SMAL_RS03560	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SMAL_RS03585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SMAL_RS03600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMAL_RS03620	COG1404	Belongs to the peptidase S8 family
SMAL_RS03640	COG1295	ribonuclease BN
SMAL_RS03645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMAL_RS03655	COG2801	Transposase and inactivated derivatives
SMAL_RS03655	COG3415	Transposase
SMAL_RS03665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMAL_RS03670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMAL_RS03685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMAL_RS03695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMAL_RS03705	COG0193	aminoacyl-tRNA hydrolase activity
SMAL_RS03710	COG0012	GTP binding
SMAL_RS03735	COG2197	response regulator
SMAL_RS03740	COG0784	Response regulator, receiver
SMAL_RS03740	COG2205	protein histidine kinase activity
SMAL_RS03745	COG3706	GGDEF domain
SMAL_RS03745	COG4251	negative regulation of phosphorylation
SMAL_RS03745	COG2203	Gaf domain
SMAL_RS03745	COG5001	Diguanylate cyclase
SMAL_RS03750	COG0784	Response regulator, receiver
SMAL_RS03750	COG2205	protein histidine kinase activity
SMAL_RS03755	COG4206	TonB-dependent receptor
SMAL_RS03760	COG4242	Belongs to the peptidase S51 family
SMAL_RS03785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMAL_RS03800	COG0250	Participates in transcription elongation, termination and antitermination
SMAL_RS03805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMAL_RS03810	COG0081	regulation of translation
SMAL_RS03815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMAL_RS03820	COG0222	ribosome binding
SMAL_RS03825	COG0085	RNA polymerase activity
SMAL_RS03830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMAL_RS03835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMAL_RS03840	COG0049	tRNA binding
SMAL_RS03845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMAL_RS03850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMAL_RS03855	COG0051	transcription antitermination factor activity, RNA binding
SMAL_RS03860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMAL_RS03865	COG0088	Forms part of the polypeptide exit tunnel
SMAL_RS03870	COG0089	rRNA binding
SMAL_RS03875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMAL_RS03880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMAL_RS03885	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMAL_RS03890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMAL_RS03895	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMAL_RS03900	COG0255	Belongs to the universal ribosomal protein uL29 family
SMAL_RS03905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMAL_RS03910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMAL_RS03915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMAL_RS03920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMAL_RS03925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMAL_RS03930	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMAL_RS03935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMAL_RS03940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMAL_RS03945	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMAL_RS03950	COG1841	ribosomal large subunit assembly
SMAL_RS03955	COG0200	Binds to the 23S rRNA
SMAL_RS03960	COG0201	protein transport
SMAL_RS03965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMAL_RS03970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMAL_RS03975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMAL_RS03980	COG0202	RNA polymerase activity
SMAL_RS03985	COG0203	ribosomal protein L17
SMAL_RS04000	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMAL_RS04010	COG0154	amidase activity
SMAL_RS04025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMAL_RS04030	COG0039	L-malate dehydrogenase activity
SMAL_RS04035	COG0564	pseudouridine synthase activity
SMAL_RS04040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMAL_RS04055	COG0625	glutathione transferase activity
SMAL_RS04065	COG1902	pentaerythritol trinitrate reductase activity
SMAL_RS04065	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMAL_RS04070	COG2364	Membrane
SMAL_RS04075	COG0604	alcohol dehydrogenase
SMAL_RS04090	COG1187	pseudouridine synthase activity
SMAL_RS04110	COG1063	alcohol dehydrogenase
SMAL_RS04120	COG0588	phosphoglycerate mutase activity
SMAL_RS04125	COG0285	dihydrofolate synthase activity
SMAL_RS04145	COG2833	Protein of unknown function (DUF455)
SMAL_RS04155	COG3291	Pkd domain containing protein
SMAL_RS04160	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMAL_RS04165	COG0671	phosphoesterase, PA-phosphatase related
SMAL_RS04170	COG0438	transferase activity, transferring glycosyl groups
SMAL_RS04180	COG4206	TonB-dependent receptor
SMAL_RS04185	COG0248	Ppx GppA phosphatase
SMAL_RS04190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMAL_RS04205	COG4783	chaperone-mediated protein folding
SMAL_RS04220	COG0473	3-isopropylmalate dehydrogenase activity
SMAL_RS04285	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMAL_RS04290	COG0740	serine-type endopeptidase activity
SMAL_RS04295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMAL_RS04335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMAL_RS04340	COG3942	CHAP domain
SMAL_RS04340	COG1388	LysM domain
SMAL_RS04345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMAL_RS04350	COG2226	methyltransferase
SMAL_RS04360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMAL_RS04365	COG0631	protein serine/threonine phosphatase activity
SMAL_RS04390	COG0859	PFAM glycosyl transferase family 9
SMAL_RS04395	COG3642	lipopolysaccharide core region biosynthetic process
SMAL_RS04400	COG1234	tRNA 3'-trailer cleavage
SMAL_RS04410	COG2076	Multidrug Resistance protein
SMAL_RS04435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMAL_RS04440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMAL_RS04450	COG0537	adenosine 5'-monophosphoramidase activity
SMAL_RS04470	COG0714	Associated with various cellular activities
SMAL_RS04485	COG1399	metal-binding, possibly nucleic acid-binding protein
SMAL_RS04490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMAL_RS04495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMAL_RS04505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMAL_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS04520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMAL_RS04525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMAL_RS04530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMAL_RS04535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMAL_RS04555	COG1942	4-Oxalocrotonate Tautomerase
SMAL_RS04700	COG4774	siderophore transport
SMAL_RS04710	COG2223	nitrite transmembrane transporter activity
SMAL_RS04730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMAL_RS04735	COG0697	spore germination
SMAL_RS04745	COG0477	Major facilitator Superfamily
SMAL_RS04755	COG2205	protein histidine kinase activity
SMAL_RS04765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS04805	COG0583	DNA-binding transcription factor activity
SMAL_RS04815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMAL_RS04830	COG0667	Aldo Keto reductase
SMAL_RS04845	COG0456	acetyltransferase
SMAL_RS04855	COG2818	Glycosylase
SMAL_RS04860	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SMAL_RS04865	COG1678	Uncharacterized ACR, COG1678
SMAL_RS04870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMAL_RS04875	COG0540	Belongs to the ATCase OTCase family
SMAL_RS04895	COG2239	Acts as a magnesium transporter
SMAL_RS04900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMAL_RS04915	COG1660	Displays ATPase and GTPase activities
SMAL_RS04920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SMAL_RS04925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMAL_RS04930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMAL_RS04940	COG1137	ATPase activity
SMAL_RS04955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SMAL_RS04970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMAL_RS04990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMAL_RS05010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMAL_RS05020	COG0628	permease
SMAL_RS05035	COG2801	Transposase and inactivated derivatives
SMAL_RS05040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMAL_RS05050	COG2261	transglycosylase associated protein
SMAL_RS05060	COG1555	photosystem II stabilization
SMAL_RS05080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SMAL_RS05085	COG1477	protein flavinylation
SMAL_RS05105	COG4771	TonB-dependent receptor
SMAL_RS05115	COG3128	pkhd-type hydroxylase
SMAL_RS05125	COG4774	siderophore transport
SMAL_RS05135	COG2146	nitrite reductase [NAD(P)H] activity
SMAL_RS05150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMAL_RS05155	COG0719	Fe-S assembly protein
SMAL_RS05160	COG0396	ATPase activity
SMAL_RS05170	COG0719	Fe-S assembly protein
SMAL_RS05175	COG1959	2 iron, 2 sulfur cluster binding
SMAL_RS05205	COG1764	response to oxidative stress
SMAL_RS05210	COG0384	phenazine biosynthesis protein PhzF
SMAL_RS05215	COG0384	phenazine biosynthesis protein PhzF
SMAL_RS05220	COG0527	aspartate kinase activity
SMAL_RS05230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMAL_RS05245	COG0142	geranyltranstransferase activity
SMAL_RS05250	COG0366	Alpha amylase catalytic
SMAL_RS05260	COG1082	Xylose isomerase domain protein TIM barrel
SMAL_RS05270	COG2211	Major facilitator Superfamily
SMAL_RS05270	COG2190	(PTS) system
SMAL_RS05310	COG1131	(ABC) transporter
SMAL_RS05315	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SMAL_RS05330	COG0629	single-stranded DNA binding
SMAL_RS05335	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SMAL_RS05340	COG1322	Protein conserved in bacteria
SMAL_RS05345	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SMAL_RS05350	COG0300	oxidoreductase activity
SMAL_RS05390	COG0673	inositol 2-dehydrogenase activity
SMAL_RS05395	COG2211	Major facilitator Superfamily
SMAL_RS05405	COG1609	Transcriptional regulator
SMAL_RS05420	COG0583	DNA-binding transcription factor activity
SMAL_RS05445	COG0519	Catalyzes the synthesis of GMP from XMP
SMAL_RS05450	COG0583	DNA-binding transcription factor activity
SMAL_RS05455	COG1073	alpha beta
SMAL_RS05465	COG0640	Transcriptional regulator
SMAL_RS05480	COG3655	Transcriptional regulator
SMAL_RS05485	COG1253	flavin adenine dinucleotide binding
SMAL_RS05505	COG0477	Major facilitator Superfamily
SMAL_RS05520	COG1802	Transcriptional regulator
SMAL_RS05555	COG3052	prosthetic group binding
SMAL_RS05570	COG0579	oxidoreductase
SMAL_RS05595	COG3104	oligopeptide transport
SMAL_RS05605	COG1297	OPT oligopeptide transporter protein
SMAL_RS05610	COG0823	Involved in the tonB-independent uptake of proteins
SMAL_RS05610	COG1506	peptidase
SMAL_RS05625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SMAL_RS05630	COG2894	cell division
SMAL_RS05635	COG0850	regulation of cytokinetic process
SMAL_RS05645	COG4585	Histidine kinase
SMAL_RS05650	COG2197	response regulator
SMAL_RS05690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMAL_RS05700	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SMAL_RS05710	COG1595	DNA-templated transcription, initiation
SMAL_RS05720	COG1946	Acyl-CoA thioesterase
SMAL_RS05740	COG0824	Thioesterase
SMAL_RS05745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMAL_RS05750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMAL_RS05755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMAL_RS05760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMAL_RS05765	COG0268	Binds directly to 16S ribosomal RNA
SMAL_RS05770	COG0728	peptidoglycan biosynthetic process
SMAL_RS05775	COG0196	riboflavin kinase activity
SMAL_RS05780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMAL_RS05790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMAL_RS05815	COG4206	TonB-dependent receptor
SMAL_RS05835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMAL_RS05865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMAL_RS05870	COG1845	cytochrome c oxidase, subunit III
SMAL_RS05875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SMAL_RS05890	COG0326	Molecular chaperone. Has ATPase activity
SMAL_RS05910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMAL_RS05925	COG0228	four-way junction DNA binding
SMAL_RS05930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMAL_RS05935	COG0336	Belongs to the RNA methyltransferase TrmD family
SMAL_RS05940	COG0335	large ribosomal subunit rRNA binding
SMAL_RS05960	COG0534	Mate efflux family protein
SMAL_RS05985	COG0753	catalase activity
SMAL_RS06005	COG0840	transmembrane signaling receptor activity
SMAL_RS06025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS06050	COG0024	Methionine aminopeptidase
SMAL_RS06075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMAL_RS06100	COG1647	Serine aminopeptidase, S33
SMAL_RS06105	COG0642	Histidine kinase
SMAL_RS06125	COG2814	Major facilitator Superfamily
SMAL_RS06130	COG3706	GGDEF domain
SMAL_RS06150	COG0588	phosphoglycerate mutase activity
SMAL_RS06155	COG3590	peptidase
SMAL_RS06165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMAL_RS06175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SMAL_RS06180	COG0745	RESPONSE REGULATOR receiver
SMAL_RS06185	COG2205	protein histidine kinase activity
SMAL_RS06190	COG4452	Inner membrane protein CreD
SMAL_RS06205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMAL_RS06210	COG0735	belongs to the Fur family
SMAL_RS06250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMAL_RS06290	COG5001	Diguanylate cyclase
SMAL_RS06290	COG5002	protein histidine kinase activity
SMAL_RS06295	COG2199	diguanylate cyclase activity
SMAL_RS06300	COG1187	pseudouridine synthase activity
SMAL_RS06310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMAL_RS06335	COG1132	(ABC) transporter
SMAL_RS06380	COG1695	Transcriptional regulator
SMAL_RS06400	COG1981	membrane
SMAL_RS06405	COG0825	malonyl-CoA metabolic process
SMAL_RS06430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMAL_RS06440	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMAL_RS06445	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMAL_RS06450	COG0750	zinc metalloprotease
SMAL_RS06460	COG0575	Belongs to the CDS family
SMAL_RS06465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMAL_RS06470	COG0233	cytoplasmic translational termination
SMAL_RS06475	COG0528	UMP kinase activity
SMAL_RS06485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMAL_RS06490	COG0052	Belongs to the universal ribosomal protein uS2 family
SMAL_RS06530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SMAL_RS06545	COG1393	Belongs to the ArsC family
SMAL_RS06550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMAL_RS06560	COG0367	asparagine synthase
SMAL_RS06565	COG0475	glutathione-regulated potassium exporter activity
SMAL_RS06600	COG1566	PFAM secretion protein HlyD family protein
SMAL_RS06605	COG2814	Major facilitator Superfamily
SMAL_RS06620	COG0583	DNA-binding transcription factor activity
SMAL_RS06640	COG0557	exoribonuclease II activity
SMAL_RS06650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMAL_RS06655	COG1538	Outer membrane efflux protein
SMAL_RS06660	COG0577	efflux transmembrane transporter activity
SMAL_RS06660	COG1136	(ABC) transporter
SMAL_RS06665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS06675	COG2205	protein histidine kinase activity
SMAL_RS06685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMAL_RS06690	COG2259	Doxx family
SMAL_RS06700	COG3220	belongs to the UPF0276 family
SMAL_RS06710	COG0704	Plays a role in the regulation of phosphate uptake
SMAL_RS06720	COG0581	inorganic phosphate transmembrane transporter activity
SMAL_RS06725	COG0573	inorganic phosphate transmembrane transporter activity
SMAL_RS06730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMAL_RS06740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMAL_RS06750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMAL_RS06760	COG1024	Enoyl-CoA hydratase
SMAL_RS06770	COG0494	nUDIX hydrolase
SMAL_RS06790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMAL_RS06790	COG0116	Belongs to the methyltransferase superfamily
SMAL_RS06815	COG2733	membrane
SMAL_RS06825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMAL_RS06830	COG1012	belongs to the aldehyde dehydrogenase family
SMAL_RS06840	COG0477	Major facilitator Superfamily
SMAL_RS06845	COG2703	oxygen carrier activity
SMAL_RS06870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMAL_RS06875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMAL_RS06880	COG0174	glutamine synthetase
SMAL_RS06890	COG2072	flavoprotein involved in K transport
SMAL_RS06895	COG3842	ATPase activity
SMAL_RS06900	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMAL_RS06905	COG1177	transmembrane transport
SMAL_RS06910	COG1012	belongs to the aldehyde dehydrogenase family
SMAL_RS06925	COG4535	Mg2 and Co2 transporter CorC
SMAL_RS06940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMAL_RS06945	COG1702	phosphate starvation-inducible protein PhoH
SMAL_RS06955	COG1131	(ABC) transporter
SMAL_RS06960	COG0842	Transport permease protein
SMAL_RS06965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMAL_RS06980	COG0741	lytic transglycosylase activity
SMAL_RS06985	COG0723	plastoquinol--plastocyanin reductase activity
SMAL_RS06990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMAL_RS06995	COG2857	Cytochrome c1
SMAL_RS07000	COG0625	glutathione transferase activity
SMAL_RS07005	COG2969	positive regulation of protein catabolic process
SMAL_RS07040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMAL_RS07050	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SMAL_RS07065	COG1611	Belongs to the LOG family
SMAL_RS07110	COG0556	nucleotide-excision repair
SMAL_RS07150	COG3713	MltA-interacting MipA family protein
SMAL_RS07160	COG2205	protein histidine kinase activity
SMAL_RS07170	COG0811	peptide transport
SMAL_RS07185	COG1663	tetraacyldisaccharide 4'-kinase activity
SMAL_RS07190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMAL_RS07195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMAL_RS07205	COG0322	excinuclease ABC activity
SMAL_RS07245	COG0577	efflux transmembrane transporter activity
SMAL_RS07245	COG1136	(ABC) transporter
SMAL_RS07285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMAL_RS07320	COG1917	Cupin 2, conserved barrel domain protein
SMAL_RS07320	COG4977	sequence-specific DNA binding
SMAL_RS07325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMAL_RS07345	COG0348	domain, Protein
SMAL_RS07360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMAL_RS07375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SMAL_RS07380	COG0069	glutamate synthase activity
SMAL_RS07410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMAL_RS07425	COG1253	flavin adenine dinucleotide binding
SMAL_RS07435	COG0306	phosphate transporter
SMAL_RS07445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMAL_RS07460	COG0504	CTP synthase activity
SMAL_RS07465	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMAL_RS07480	COG0148	phosphopyruvate hydratase activity
SMAL_RS07485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SMAL_RS07490	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMAL_RS07495	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMAL_RS07505	COG2840	Smr protein MutS2
SMAL_RS07510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMAL_RS07515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMAL_RS07545	COG1534	Rna-binding protein
SMAL_RS07550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SMAL_RS07565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMAL_RS07570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMAL_RS07575	COG1923	regulation of RNA biosynthetic process
SMAL_RS07580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMAL_RS07585	COG1546	Belongs to the CinA family
SMAL_RS07590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMAL_RS07595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMAL_RS07600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMAL_RS07605	COG2137	regulation of response to DNA damage stimulus
SMAL_RS07610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMAL_RS07615	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SMAL_RS07635	COG4773	Receptor
SMAL_RS07650	COG1940	carbohydrate kinase activity
SMAL_RS07690	COG3540	Alkaline phosphatase
SMAL_RS07705	COG3258	Cytochrome c
SMAL_RS07720	COG2223	nitrite transmembrane transporter activity
SMAL_RS07735	COG1741	Belongs to the pirin family
SMAL_RS07740	COG0583	DNA-binding transcription factor activity
SMAL_RS07765	COG0352	thiamine-phosphate diphosphorylase activity
SMAL_RS07765	COG0351	phosphomethylpyrimidine kinase
SMAL_RS07780	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SMAL_RS07785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMAL_RS07795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMAL_RS07805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SMAL_RS07810	COG0477	Major facilitator Superfamily
SMAL_RS07820	COG0617	tRNA 3'-terminal CCA addition
SMAL_RS07825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMAL_RS07830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMAL_RS07835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMAL_RS07845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMAL_RS07850	COG0166	Belongs to the GPI family
SMAL_RS07855	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SMAL_RS07865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMAL_RS07870	COG0671	phosphoesterase, PA-phosphatase related
SMAL_RS07880	COG0800	Aldolase
SMAL_RS07885	COG0129	dihydroxy-acid dehydratase activity
SMAL_RS07895	COG0837	glucose binding
SMAL_RS07905	COG3842	ATPase activity
SMAL_RS07915	COG2009	succinate dehydrogenase
SMAL_RS07920	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SMAL_RS07925	COG1053	succinate dehydrogenase
SMAL_RS07945	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMAL_RS07960	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SMAL_RS07970	COG0552	protein localization to endoplasmic reticulum
SMAL_RS07985	COG0742	ribosomal rna small subunit methyltransferase
SMAL_RS07990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMAL_RS08000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMAL_RS08005	COG0405	Gamma-glutamyltransferase
SMAL_RS08010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMAL_RS08020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMAL_RS08040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMAL_RS08050	COG0415	Belongs to the DNA photolyase family
SMAL_RS08055	COG2885	chlorophyll binding
SMAL_RS08060	COG0583	DNA-binding transcription factor activity
SMAL_RS08150	COG1404	Belongs to the peptidase S8 family
SMAL_RS08185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMAL_RS08200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMAL_RS08205	COG0735	belongs to the Fur family
SMAL_RS08215	COG0583	DNA-binding transcription factor activity
SMAL_RS08220	COG0497	DNA recombination
SMAL_RS08225	COG1420	regulation of RNA biosynthetic process
SMAL_RS08230	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMAL_RS08235	COG0443	Heat shock 70 kDa protein
SMAL_RS08240	COG0484	heat shock protein binding
SMAL_RS08245	COG2207	Transcriptional regulator
SMAL_RS08250	COG2223	nitrite transmembrane transporter activity
SMAL_RS08255	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
SMAL_RS08260	COG0287	Prephenate dehydrogenase
SMAL_RS08260	COG1605	Chorismate mutase
SMAL_RS08270	COG1132	(ABC) transporter
SMAL_RS08290	COG4251	negative regulation of phosphorylation
SMAL_RS08290	COG2203	Gaf domain
SMAL_RS08290	COG3706	GGDEF domain
SMAL_RS08290	COG5001	Diguanylate cyclase
SMAL_RS08300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMAL_RS08305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMAL_RS08310	COG0343	queuine tRNA-ribosyltransferase activity
SMAL_RS08315	COG1862	Preprotein translocase
SMAL_RS08325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMAL_RS08330	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMAL_RS08340	COG2081	HI0933 family
SMAL_RS08345	COG4681	YaeQ
SMAL_RS08350	COG0564	pseudouridine synthase activity
SMAL_RS08365	COG0625	glutathione transferase activity
SMAL_RS08370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SMAL_RS08375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMAL_RS08380	COG0513	Belongs to the DEAD box helicase family
SMAL_RS08390	COG0583	DNA-binding transcription factor activity
SMAL_RS08395	COG0488	(ABC) transporter
SMAL_RS08425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL_RS08440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMAL_RS08445	COG2957	Belongs to the agmatine deiminase family
SMAL_RS08455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMAL_RS08460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMAL_RS08470	COG0776	regulation of translation
SMAL_RS08480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SMAL_RS08495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMAL_RS08500	COG0183	Belongs to the thiolase family
SMAL_RS08505	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMAL_RS08505	COG1024	Enoyl-CoA hydratase
SMAL_RS08515	COG0105	UTP biosynthetic process
SMAL_RS08520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMAL_RS08530	COG1426	Protein conserved in bacteria
SMAL_RS08530	COG1426	Protein conserved in bacteria
SMAL_RS08535	COG2976	Protein conserved in bacteria
SMAL_RS08540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMAL_RS08545	COG1160	GTP binding
SMAL_RS08565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMAL_RS08570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMAL_RS08570	COG0475	glutathione-regulated potassium exporter activity
SMAL_RS08590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMAL_RS08590	COG0519	Catalyzes the synthesis of GMP from XMP
SMAL_RS08605	COG0583	DNA-binding transcription factor activity
SMAL_RS08625	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS08635	COG0640	Transcriptional regulator
SMAL_RS08650	COG0300	oxidoreductase activity
SMAL_RS08655	COG2207	Transcriptional regulator
SMAL_RS08685	COG0431	NADPH-dependent FMN reductase
SMAL_RS08695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMAL_RS08700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMAL_RS08705	COG1473	amidohydrolase
SMAL_RS08715	COG0765	amino acid transport
SMAL_RS08720	COG1126	abc transporter atp-binding protein
SMAL_RS08725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMAL_RS08740	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS08770	COG0583	DNA-binding transcription factor activity
SMAL_RS08775	COG0477	Major facilitator Superfamily
SMAL_RS08780	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS08790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMAL_RS08810	COG1309	transcriptional regulator
SMAL_RS08825	COG0697	spore germination
SMAL_RS08830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMAL_RS08835	COG0167	dihydroorotate dehydrogenase activity
SMAL_RS08850	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS08855	COG1012	belongs to the aldehyde dehydrogenase family
SMAL_RS08865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMAL_RS08900	COG0784	Response regulator, receiver
SMAL_RS08900	COG4191	Histidine kinase
SMAL_RS08905	COG3850	Histidine kinase
SMAL_RS08905	COG3437	response regulator, receiver
SMAL_RS08905	COG4999	Histidine kinase
SMAL_RS08905	COG2205	protein histidine kinase activity
SMAL_RS08910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMAL_RS08920	COG5002	protein histidine kinase activity
SMAL_RS08930	COG0640	Transcriptional regulator
SMAL_RS08980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMAL_RS08985	COG0124	histidyl-tRNA synthetase
SMAL_RS09000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMAL_RS09005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMAL_RS09010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMAL_RS09015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMAL_RS09015	COG0131	Imidazoleglycerol-phosphate dehydratase
SMAL_RS09020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMAL_RS09025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMAL_RS09030	COG0107	imidazoleglycerol-phosphate synthase activity
SMAL_RS09035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMAL_RS09035	COG0140	phosphoribosyl-ATP diphosphatase activity
SMAL_RS09055	COG1446	asparaginase
SMAL_RS09060	COG3142	Participates in the control of copper homeostasis
SMAL_RS09075	COG0789	Transcriptional regulator
SMAL_RS09090	COG3537	Alpha-1,2-mannosidase
SMAL_RS09095	COG1609	Transcriptional regulator
SMAL_RS09105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMAL_RS09120	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SMAL_RS09125	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SMAL_RS09130	COG0235	Class ii aldolase
SMAL_RS09140	COG0531	amino acid
SMAL_RS09145	COG0531	amino acid
SMAL_RS09155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMAL_RS09160	COG0277	FAD linked oxidase domain protein
SMAL_RS09175	COG2205	protein histidine kinase activity
SMAL_RS09180	COG0745	RESPONSE REGULATOR receiver
SMAL_RS09185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS09210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMAL_RS09255	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMAL_RS09270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMAL_RS09275	COG0505	Belongs to the CarA family
SMAL_RS09280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMAL_RS09285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMAL_RS09305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMAL_RS09315	COG4676	Protein conserved in bacteria
SMAL_RS09330	COG3279	Response regulator of the LytR AlgR family
SMAL_RS09335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMAL_RS09345	COG1012	belongs to the aldehyde dehydrogenase family
SMAL_RS09355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMAL_RS09365	COG2198	Histidine kinase
SMAL_RS09365	COG0784	Response regulator, receiver
SMAL_RS09365	COG2205	protein histidine kinase activity
SMAL_RS09370	COG1024	Enoyl-CoA hydratase
SMAL_RS09375	COG0318	PFAM AMP-dependent synthetase and ligase
SMAL_RS09380	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SMAL_RS09385	COG1012	belongs to the aldehyde dehydrogenase family
SMAL_RS09390	COG1309	transcriptional regulator
SMAL_RS09395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMAL_RS09430	COG2267	carboxylic ester hydrolase activity
SMAL_RS09440	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SMAL_RS09450	COG0840	transmembrane signaling receptor activity
SMAL_RS09455	COG0840	transmembrane signaling receptor activity
SMAL_RS09465	COG0835	chemotaxis
SMAL_RS09470	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SMAL_RS09475	COG0840	transmembrane signaling receptor activity
SMAL_RS09485	COG0745	RESPONSE REGULATOR receiver
SMAL_RS09495	COG0835	chemotaxis
SMAL_RS09505	COG1360	Flagellar Motor Protein
SMAL_RS09510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SMAL_RS09515	COG0784	Response regulator, receiver
SMAL_RS09515	COG0643	Histidine kinase
SMAL_RS09515	COG2198	Histidine kinase
SMAL_RS09520	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SMAL_RS09545	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMAL_RS09550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMAL_RS09565	COG1987	bacterial-type flagellum assembly
SMAL_RS09575	COG3190	flagellar
SMAL_RS09625	COG1677	Flagellar hook-basal body complex protein FliE
SMAL_RS09650	COG2801	Transposase and inactivated derivatives
SMAL_RS09650	COG3415	Transposase
SMAL_RS09655	COG3415	Transposase
SMAL_RS09655	COG2801	Transposase and inactivated derivatives
SMAL_RS09660	COG2197	response regulator
SMAL_RS09680	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SMAL_RS09685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMAL_RS09720	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SMAL_RS09730	COG4787	bacterial-type flagellum-dependent cell motility
SMAL_RS09750	COG1815	bacterial-type flagellum-dependent cell motility
SMAL_RS09755	COG0835	chemotaxis
SMAL_RS09755	COG0784	Response regulator, receiver
SMAL_RS09775	COG5002	protein histidine kinase activity
SMAL_RS09810	COG2915	High frequency lysogenization protein hflD homolog
SMAL_RS09815	COG0482	sulfurtransferase activity
SMAL_RS09830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMAL_RS09840	COG0542	response to heat
SMAL_RS09880	COG0492	ferredoxin-NADP+ reductase activity
SMAL_RS09885	COG1674	ftsk spoiiie
SMAL_RS09900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMAL_RS09905	COG3152	Membrane
SMAL_RS09915	COG2819	hydrolase of the alpha beta superfamily
SMAL_RS09925	COG4558	Periplasmic binding protein
SMAL_RS09930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMAL_RS09935	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SMAL_RS09945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMAL_RS09960	COG2198	Histidine kinase
SMAL_RS09960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMAL_RS09960	COG0784	Response regulator, receiver
SMAL_RS09960	COG2205	protein histidine kinase activity
SMAL_RS09975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMAL_RS09990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMAL_RS10000	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SMAL_RS10015	COG1595	DNA-templated transcription, initiation
SMAL_RS10025	COG0702	epimerase
SMAL_RS10030	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SMAL_RS10040	COG0456	acetyltransferase
SMAL_RS10050	COG2259	Doxx family
SMAL_RS10055	COG0583	DNA-binding transcription factor activity
SMAL_RS10060	COG1741	Belongs to the pirin family
SMAL_RS10090	COG1431	PFAM Stem cell self-renewal protein Piwi
SMAL_RS10110	COG0431	NADPH-dependent FMN reductase
SMAL_RS10125	COG0798	PFAM Bile acid sodium symporter
SMAL_RS10130	COG0492	ferredoxin-NADP+ reductase activity
SMAL_RS10170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMAL_RS10175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMAL_RS10180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SMAL_RS10185	COG2080	2 iron, 2 sulfur cluster binding
SMAL_RS10190	COG1764	response to oxidative stress
SMAL_RS10200	COG0583	DNA-binding transcription factor activity
SMAL_RS10220	COG1595	DNA-templated transcription, initiation
SMAL_RS10225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SMAL_RS10235	COG1309	transcriptional regulator
SMAL_RS10250	COG1902	pentaerythritol trinitrate reductase activity
SMAL_RS10255	COG4221	oxidoreductase activity
SMAL_RS10260	COG0604	alcohol dehydrogenase
SMAL_RS10280	COG0667	Aldo Keto reductase
SMAL_RS10355	COG0649	NAD binding
SMAL_RS10360	COG1609	Transcriptional regulator
SMAL_RS10365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMAL_RS10365	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMAL_RS10370	COG1105	Belongs to the carbohydrate kinase PfkB family
SMAL_RS10375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMAL_RS10375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMAL_RS10385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SMAL_RS10405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMAL_RS10410	COG0583	DNA-binding transcription factor activity
SMAL_RS10425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMAL_RS10440	COG5265	(ABC) transporter
SMAL_RS10460	COG4555	ABC transporter
SMAL_RS10480	COG2207	Transcriptional regulator
SMAL_RS10505	COG2205	protein histidine kinase activity
SMAL_RS10515	COG0318	PFAM AMP-dependent synthetase and ligase
SMAL_RS10525	COG2186	Transcriptional regulator
SMAL_RS10545	COG2271	Major facilitator Superfamily
SMAL_RS10550	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS10590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMAL_RS10600	COG0346	lactoylglutathione lyase activity
SMAL_RS10605	COG2226	methyltransferase
SMAL_RS10615	COG0583	DNA-binding transcription factor activity
SMAL_RS10775	COG5001	Diguanylate cyclase
SMAL_RS10775	COG3447	MASE1 domain protein
SMAL_RS10775	COG5002	protein histidine kinase activity
SMAL_RS10780	COG0577	efflux transmembrane transporter activity
SMAL_RS10780	COG1136	(ABC) transporter
SMAL_RS10785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS10795	COG0745	RESPONSE REGULATOR receiver
SMAL_RS10800	COG2205	protein histidine kinase activity
SMAL_RS10820	COG4774	siderophore transport
SMAL_RS10840	COG3214	Protein conserved in bacteria
SMAL_RS10850	COG4774	siderophore transport
SMAL_RS10865	COG0596	Alpha beta hydrolase
SMAL_RS10880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMAL_RS10885	COG1285	pathogenesis
SMAL_RS10890	COG4191	Histidine kinase
SMAL_RS10895	COG4566	intracellular signal transduction
SMAL_RS10940	COG0243	molybdopterin cofactor binding
SMAL_RS10945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SMAL_RS10965	COG0477	Major facilitator Superfamily
SMAL_RS10990	COG1136	(ABC) transporter
SMAL_RS11005	COG4771	TonB-dependent receptor
SMAL_RS11015	COG2372	response to copper ion
SMAL_RS11025	COG0745	RESPONSE REGULATOR receiver
SMAL_RS11030	COG5002	protein histidine kinase activity
SMAL_RS11035	COG0583	DNA-binding transcription factor activity
SMAL_RS11040	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS11070	COG3537	Alpha-1,2-mannosidase
SMAL_RS11075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMAL_RS11090	COG0477	Major facilitator Superfamily
SMAL_RS11110	COG3920	Histidine kinase
SMAL_RS11110	COG2202	Pas domain
SMAL_RS11115	COG0745	RESPONSE REGULATOR receiver
SMAL_RS11155	COG1335	isochorismatase
SMAL_RS11160	COG1335	isochorismatase
SMAL_RS11170	COG0488	(ABC) transporter
SMAL_RS11195	COG0811	peptide transport
SMAL_RS11225	COG4795	General secretion pathway protein
SMAL_RS11320	COG0840	transmembrane signaling receptor activity
SMAL_RS11325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SMAL_RS11330	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SMAL_RS11335	COG4149	molybdate abc transporter
SMAL_RS11340	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMAL_RS11345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMAL_RS11360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMAL_RS11365	COG2181	nitrate reductase activity
SMAL_RS11370	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SMAL_RS11375	COG1140	nitrate reductase beta subunit
SMAL_RS11380	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SMAL_RS11385	COG2223	nitrite transmembrane transporter activity
SMAL_RS11395	COG0746	molybdenum cofactor guanylyltransferase activity
SMAL_RS11400	COG0314	molybdopterin synthase activity
SMAL_RS11410	COG0303	'Molybdopterin
SMAL_RS11415	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMAL_RS11415	COG0315	cyclic pyranopterin monophosphate synthase activity
SMAL_RS11420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMAL_RS11460	COG2207	Transcriptional regulator
SMAL_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS11555	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SMAL_RS11555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMAL_RS11560	COG3433	isochorismatase activity
SMAL_RS11560	COG1535	isochorismatase
SMAL_RS11565	COG1535	isochorismatase
SMAL_RS11565	COG3433	isochorismatase activity
SMAL_RS11570	COG1021	2,3-dihydroxybenzoate-AMP ligase
SMAL_RS11575	COG1169	isochorismate synthase
SMAL_RS11585	COG2409	Drug exporters of the RND superfamily
SMAL_RS11590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMAL_RS11655	COG1914	H( )-stimulated, divalent metal cation uptake system
SMAL_RS11660	COG3118	belongs to the thioredoxin family
SMAL_RS11670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMAL_RS11675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMAL_RS11680	COG0604	alcohol dehydrogenase
SMAL_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS11680	COG3321	synthase
SMAL_RS11685	COG4206	TonB-dependent receptor
SMAL_RS11690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMAL_RS11735	COG4772	TonB-dependent receptor
SMAL_RS11755	COG2226	methyltransferase
SMAL_RS11800	COG4964	Belongs to the GSP D family
SMAL_RS11855	COG2814	Major facilitator Superfamily
SMAL_RS11865	COG1228	amidohydrolase
SMAL_RS11890	COG3850	Histidine kinase
SMAL_RS11895	COG2197	response regulator
SMAL_RS11900	COG4946	Tricorn protease homolog
SMAL_RS11900	COG1506	peptidase
SMAL_RS11900	COG0823	Involved in the tonB-independent uptake of proteins
SMAL_RS11905	COG4565	transcriptional regulatory protein
SMAL_RS11910	COG3275	phosphorelay sensor kinase activity
SMAL_RS11915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SMAL_RS11925	COG0583	DNA-binding transcription factor activity
SMAL_RS11940	COG3161	chorismate lyase activity
SMAL_RS11985	COG0277	FAD linked oxidase domain protein
SMAL_RS11990	COG1304	FMN binding
SMAL_RS11995	COG2186	Transcriptional regulator
SMAL_RS12005	COG1285	pathogenesis
SMAL_RS12040	COG2814	Major facilitator Superfamily
SMAL_RS12095	COG0587	DNA-directed DNA polymerase activity
SMAL_RS12110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMAL_RS12115	COG0519	Catalyzes the synthesis of GMP from XMP
SMAL_RS12115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMAL_RS12130	COG1595	DNA-templated transcription, initiation
SMAL_RS12140	COG4206	TonB-dependent receptor
SMAL_RS12140	COG1629	transport
SMAL_RS12165	COG0531	amino acid
SMAL_RS12180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMAL_RS12190	COG0789	Transcriptional regulator
SMAL_RS12275	COG5002	protein histidine kinase activity
SMAL_RS12275	COG5001	Diguanylate cyclase
SMAL_RS12275	COG3447	MASE1 domain protein
SMAL_RS12280	COG2183	response to ionizing radiation
SMAL_RS12305	COG3243	poly(R)-hydroxyalkanoic acid synthase
SMAL_RS12320	COG2226	methyltransferase
SMAL_RS12320	COG1073	alpha beta
SMAL_RS12335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SMAL_RS12345	COG0668	transmembrane transport
SMAL_RS12350	COG1902	pentaerythritol trinitrate reductase activity
SMAL_RS12360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SMAL_RS12370	COG1733	regulation of RNA biosynthetic process
SMAL_RS12375	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMAL_RS12465	COG2948	multi-organism process
SMAL_RS12475	COG3736	Type IV secretory pathway, component VirB8
SMAL_RS12500	COG2814	Major facilitator Superfamily
SMAL_RS12505	COG0789	Transcriptional regulator
SMAL_RS12510	COG1902	pentaerythritol trinitrate reductase activity
SMAL_RS12510	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMAL_RS12530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMAL_RS12540	COG4774	siderophore transport
SMAL_RS12550	COG0745	RESPONSE REGULATOR receiver
SMAL_RS12570	COG0577	efflux transmembrane transporter activity
SMAL_RS12570	COG1136	(ABC) transporter
SMAL_RS12600	COG1733	regulation of RNA biosynthetic process
SMAL_RS12605	COG0604	alcohol dehydrogenase
SMAL_RS12620	COG0210	DNA helicase
SMAL_RS12890	COG0583	DNA-binding transcription factor activity
SMAL_RS12895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMAL_RS12905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMAL_RS12920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMAL_RS12925	COG1605	Chorismate mutase
SMAL_RS12925	COG0077	Prephenate dehydratase
SMAL_RS12930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMAL_RS12970	COG1228	amidohydrolase
SMAL_RS12985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SMAL_RS13030	COG2957	Belongs to the agmatine deiminase family
SMAL_RS13035	COG0583	DNA-binding transcription factor activity
SMAL_RS13090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMAL_RS13110	COG4993	Dehydrogenase
SMAL_RS13120	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMAL_RS13130	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SMAL_RS13140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMAL_RS13145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMAL_RS13160	COG0359	binds to the 23S rRNA
SMAL_RS13165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMAL_RS13170	COG0360	Binds together with S18 to 16S ribosomal RNA
SMAL_RS13180	COG0316	Belongs to the HesB IscA family
SMAL_RS13185	COG0017	Asparaginyl-tRNA synthetase
SMAL_RS13200	COG2808	Putative FMN-binding domain
SMAL_RS13205	COG0288	reversible hydration of carbon dioxide
SMAL_RS13215	COG3844	kynureninase activity
SMAL_RS13220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMAL_RS13225	COG2925	Exonuclease
SMAL_RS13250	COG2902	Dehydrogenase
SMAL_RS13260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS13265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL_RS13270	COG1960	acyl-CoA dehydrogenase activity
SMAL_RS13285	COG0646	methionine synthase
SMAL_RS13285	COG1410	methionine synthase
SMAL_RS13300	COG2900	Belongs to the SlyX family
SMAL_RS13315	COG0386	Belongs to the glutathione peroxidase family
SMAL_RS13320	COG1725	Transcriptional regulator
SMAL_RS13325	COG1131	(ABC) transporter
SMAL_RS13350	COG0114	fumarate hydratase activity
SMAL_RS13360	COG2850	peptidyl-arginine hydroxylation
SMAL_RS13370	COG0567	Dehydrogenase, E1 component
SMAL_RS13395	COG3540	Alkaline phosphatase
SMAL_RS13405	COG0305	Participates in initiation and elongation during chromosome replication
SMAL_RS13425	COG0625	glutathione transferase activity
SMAL_RS13445	COG0084	hydrolase, TatD family'
SMAL_RS13450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMAL_RS13485	COG0625	glutathione transferase activity
SMAL_RS13500	COG1595	DNA-templated transcription, initiation
SMAL_RS13505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMAL_RS13520	COG0386	Belongs to the glutathione peroxidase family
SMAL_RS13525	COG0339	signal peptide processing
SMAL_RS13530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMAL_RS13550	COG0705	Rhomboid family
SMAL_RS13555	COG3104	oligopeptide transport
SMAL_RS13565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMAL_RS13570	COG4290	ribonuclease
SMAL_RS13585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SMAL_RS13585	COG0316	Belongs to the HesB IscA family
SMAL_RS13590	COG2154	pterin-4-alpha-carbinolamine dehydratase
SMAL_RS13600	COG0428	transporter
SMAL_RS13610	COG1530	ribonuclease E activity
SMAL_RS13625	COG0395	ABC-type sugar transport system, permease component
SMAL_RS13650	COG1609	Transcriptional regulator
SMAL_RS13655	COG0271	Belongs to the BolA IbaG family
SMAL_RS13660	COG2350	Protein conserved in bacteria
SMAL_RS13670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMAL_RS13675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMAL_RS13680	COG1187	pseudouridine synthase activity
SMAL_RS13690	COG2814	Major facilitator Superfamily
SMAL_RS13715	COG0436	Aminotransferase
SMAL_RS13720	COG4133	protoheme IX ABC transporter activity
SMAL_RS13740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SMAL_RS13755	COG3088	subunit of a heme lyase
SMAL_RS13755	COG4235	cytochrome complex assembly
SMAL_RS13765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMAL_RS13775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SMAL_RS13780	COG4988	ABC transporter
SMAL_RS13790	COG1294	oxidase, subunit
SMAL_RS13820	COG0726	polysaccharide deacetylase
SMAL_RS13820	COG1649	PFAM Uncharacterised BCR, COG1649
SMAL_RS13825	COG1215	transferase activity, transferring glycosyl groups
SMAL_RS13835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMAL_RS13850	COG0165	Argininosuccinate lyase
SMAL_RS13855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMAL_RS13865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMAL_RS13870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMAL_RS13875	COG0137	argininosuccinate synthase activity
SMAL_RS13880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMAL_RS13895	COG2166	iron-sulfur cluster assembly
SMAL_RS13915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMAL_RS13935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMAL_RS13940	COG0402	S-adenosylhomocysteine deaminase activity
SMAL_RS13945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMAL_RS13950	COG1509	lysine 2,3-aminomutase activity
SMAL_RS13955	COG3300	MHYT domain
SMAL_RS13955	COG5001	Diguanylate cyclase
SMAL_RS13970	COG0483	inositol monophosphate 1-phosphatase activity
SMAL_RS13975	COG0501	Belongs to the peptidase M48B family
SMAL_RS13985	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS14005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMAL_RS14010	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMAL_RS14015	COG0802	atpase or kinase
SMAL_RS14020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMAL_RS14020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMAL_RS14025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMAL_RS14030	COG1570	exodeoxyribonuclease VII activity
SMAL_RS14040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMAL_RS14055	COG4771	TonB-dependent receptor
SMAL_RS14060	COG1309	transcriptional regulator
SMAL_RS14095	COG2169	Transcriptional regulator
SMAL_RS14095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMAL_RS14100	COG2130	NADP-dependent
SMAL_RS14130	COG1960	acyl-CoA dehydrogenase activity
SMAL_RS14140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMAL_RS14170	COG1309	transcriptional regulator
SMAL_RS14175	COG2076	Multidrug Resistance protein
SMAL_RS14185	COG1280	lysine exporter protein (LysE YggA)
SMAL_RS14190	COG0740	serine-type endopeptidase activity
SMAL_RS14205	COG1794	racemase activity, acting on amino acids and derivatives
SMAL_RS14225	COG0456	acetyltransferase
SMAL_RS14225	COG0454	-acetyltransferase
SMAL_RS14240	COG0776	regulation of translation
SMAL_RS14250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMAL_RS14255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMAL_RS14260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMAL_RS14265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMAL_RS14270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMAL_RS14300	COG1185	polyribonucleotide nucleotidyltransferase activity
SMAL_RS14305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMAL_RS14315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMAL_RS14320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMAL_RS14325	COG0195	Participates in both transcription termination and antitermination
SMAL_RS14330	COG0779	Required for maturation of 30S ribosomal subunits
SMAL_RS14345	COG1007	ATP synthesis coupled electron transport
SMAL_RS14360	COG0713	ATP synthesis coupled electron transport
SMAL_RS14370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAL_RS14375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMAL_RS14390	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SMAL_RS14395	COG0649	NAD binding
SMAL_RS14400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAL_RS14405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAL_RS14410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAL_RS14425	COG0149	triose-phosphate isomerase activity
SMAL_RS14435	COG3083	sulfuric ester hydrolase activity
SMAL_RS14440	COG0438	transferase activity, transferring glycosyl groups
SMAL_RS14445	COG0726	polysaccharide deacetylase
SMAL_RS14450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMAL_RS14455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMAL_RS14460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMAL_RS14465	COG0159	tryptophan synthase activity
SMAL_RS14475	COG0133	tryptophan synthase activity
SMAL_RS14510	COG0135	phosphoribosylanthranilate isomerase activity
SMAL_RS14515	COG0101	tRNA pseudouridine synthase activity
SMAL_RS14530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMAL_RS14535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMAL_RS14540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMAL_RS14545	COG2890	protein-(glutamine-N5) methyltransferase activity
SMAL_RS14550	COG1999	signal sequence binding
SMAL_RS14555	COG0688	phosphatidylethanolamine metabolic process
SMAL_RS14570	COG0433	COG0433 Predicted ATPase
SMAL_RS14575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMAL_RS14585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMAL_RS14590	COG0412	Dienelactone hydrolase
SMAL_RS14605	COG0717	Belongs to the dCTP deaminase family
SMAL_RS14610	COG0489	protein tyrosine kinase activity
SMAL_RS14615	COG4771	TonB-dependent receptor
SMAL_RS14620	COG4771	TonB-dependent receptor
SMAL_RS14630	COG3590	peptidase
SMAL_RS14665	COG0697	spore germination
SMAL_RS14680	COG2311	Membrane
SMAL_RS14685	COG1047	Peptidyl-prolyl cis-trans
SMAL_RS14690	COG0791	NLP P60 protein
SMAL_RS14695	COG0791	NLP P60 protein
SMAL_RS14700	COG1301	dicarboxylic acid transport
SMAL_RS14720	COG1722	exodeoxyribonuclease VII activity
SMAL_RS14725	COG0142	geranyltranstransferase activity
SMAL_RS14735	COG0312	modulator of DNA gyrase
SMAL_RS14740	COG3028	Belongs to the UPF0307 family
SMAL_RS14745	COG0312	modulator of DNA gyrase
SMAL_RS14765	COG2968	Membrane
SMAL_RS14775	COG4771	TonB-dependent receptor
SMAL_RS14785	COG2755	lipolytic protein G-D-S-L family
SMAL_RS14785	COG0657	acetylesterase activity
SMAL_RS14795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMAL_RS14805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMAL_RS14820	COG0495	leucyl-tRNA aminoacylation
SMAL_RS14830	COG3118	belongs to the thioredoxin family
SMAL_RS14840	COG5001	Diguanylate cyclase
SMAL_RS14840	COG4251	negative regulation of phosphorylation
SMAL_RS14840	COG3706	GGDEF domain
SMAL_RS14840	COG2203	Gaf domain
SMAL_RS14865	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SMAL_RS14875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMAL_RS14880	COG0346	lactoylglutathione lyase activity
SMAL_RS14890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMAL_RS14890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMAL_RS14900	COG2878	Part of a membrane complex involved in electron transport
SMAL_RS14905	COG0251	oxidation-reduction process
SMAL_RS14910	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SMAL_RS14910	COG0392	lysyltransferase activity
SMAL_RS14940	COG2824	Alkylphosphonate utilization operon protein PhnA
SMAL_RS14945	COG1077	Cell shape determining protein MreB Mrl
SMAL_RS14985	COG2801	Transposase and inactivated derivatives
SMAL_RS14995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SMAL_RS15000	COG3122	Protein conserved in bacteria
SMAL_RS15005	COG1451	nucleotide metabolic process
SMAL_RS15015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMAL_RS15035	COG0183	Belongs to the thiolase family
SMAL_RS15050	COG1960	acyl-CoA dehydrogenase activity
SMAL_RS15060	COG1793	dna ligase
SMAL_RS15065	COG1201	RNA secondary structure unwinding
SMAL_RS15080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SMAL_RS15085	COG1278	Cold shock
SMAL_RS15090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMAL_RS15095	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SMAL_RS15100	COG1472	Belongs to the glycosyl hydrolase 3 family
SMAL_RS15105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SMAL_RS15110	COG2954	triphosphatase activity
SMAL_RS15115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMAL_RS15120	COG0745	RESPONSE REGULATOR receiver
SMAL_RS15125	COG1381	Involved in DNA repair and RecF pathway recombination
SMAL_RS15130	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMAL_RS15145	COG0681	Belongs to the peptidase S26 family
SMAL_RS15150	COG0481	GTPase activity
SMAL_RS15155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMAL_RS15175	COG1741	Belongs to the pirin family
SMAL_RS15180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMAL_RS15190	COG1741	Belongs to the pirin family
SMAL_RS15195	COG1966	Carbon starvation protein
SMAL_RS15200	COG2879	small protein
SMAL_RS15215	COG2205	protein histidine kinase activity
SMAL_RS15220	COG0745	RESPONSE REGULATOR receiver
SMAL_RS15255	COG2814	Major facilitator Superfamily
SMAL_RS15260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMAL_RS15260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMAL_RS15270	COG1113	amino acid transport
SMAL_RS15275	COG2207	Transcriptional regulator
SMAL_RS15275	COG1917	Cupin 2, conserved barrel domain protein
SMAL_RS15300	COG1401	restriction endodeoxyribonuclease activity
SMAL_RS15310	COG1376	ErfK ybiS ycfS ynhG family protein
SMAL_RS15315	COG0739	heme binding
SMAL_RS15325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMAL_RS15335	COG0330	HflC and HflK could
SMAL_RS15340	COG0330	HflC and HflK could
SMAL_RS15345	COG0604	alcohol dehydrogenase
SMAL_RS15360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMAL_RS15360	COG0678	peroxiredoxin activity
SMAL_RS15370	COG4953	penicillin-binding protein 1C
SMAL_RS15375	COG2373	Large extracellular alpha-helical protein
SMAL_RS15380	COG2079	MmgE PrpD family protein
SMAL_RS15385	COG2828	Protein conserved in bacteria
SMAL_RS15395	COG3609	addiction module antidote protein, CC2985 family
SMAL_RS15425	COG0259	pyridoxamine-phosphate oxidase activity
SMAL_RS15440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMAL_RS15460	COG0477	Major facilitator Superfamily
SMAL_RS15480	COG3038	cytochrome b561
SMAL_RS15495	COG1760	l-serine dehydratase
SMAL_RS15500	COG2267	carboxylic ester hydrolase activity
SMAL_RS15505	COG0527	aspartate kinase activity
SMAL_RS15505	COG0460	homoserine dehydrogenase
SMAL_RS15510	COG0626	cystathionine gamma-synthase activity
SMAL_RS15515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMAL_RS15520	COG0739	heme binding
SMAL_RS15525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMAL_RS15530	COG1272	protein, Hemolysin III
SMAL_RS15535	COG2982	Protein involved in outer membrane biogenesis
SMAL_RS15545	COG0463	Glycosyl transferase, family 2
SMAL_RS15550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMAL_RS15555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMAL_RS15565	COG4206	TonB-dependent receptor
SMAL_RS15570	COG1309	transcriptional regulator
SMAL_RS15580	COG1960	acyl-CoA dehydrogenase activity
SMAL_RS15610	COG0583	DNA-binding transcription factor activity
SMAL_RS15620	COG0509	glycine decarboxylation via glycine cleavage system
SMAL_RS15625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMAL_RS15635	COG0330	HflC and HflK could
SMAL_RS15645	COG1742	UPF0060 membrane protein
SMAL_RS15650	COG3956	TIGRFAM MazG family protein
SMAL_RS15655	COG1218	3'(2'),5'-bisphosphate nucleotidase
SMAL_RS15660	COG0494	nUDIX hydrolase
SMAL_RS15670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMAL_RS15685	COG0643	Histidine kinase
SMAL_RS15685	COG0784	Response regulator, receiver
SMAL_RS15685	COG2198	Histidine kinase
SMAL_RS15690	COG0840	transmembrane signaling receptor activity
SMAL_RS15695	COG0835	chemotaxis
SMAL_RS15710	COG0189	ligase activity
SMAL_RS15720	COG1214	PFAM Peptidase M22, glycoprotease
SMAL_RS15725	COG1199	ATP-dependent helicase activity
SMAL_RS15735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMAL_RS15740	COG1215	transferase activity, transferring glycosyl groups
SMAL_RS15755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMAL_RS15765	COG1643	Atp-dependent helicase
SMAL_RS15770	COG0783	Belongs to the Dps family
SMAL_RS15775	COG0514	ATP-dependent DNA helicase (RecQ)
SMAL_RS15785	COG2132	Multicopper oxidase
SMAL_RS15840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMAL_RS15845	COG0602	queuosine metabolic process
SMAL_RS15855	COG2885	chlorophyll binding
SMAL_RS15860	COG0823	Involved in the tonB-independent uptake of proteins
SMAL_RS15880	COG0824	Thioesterase
SMAL_RS15885	COG2255	four-way junction helicase activity
SMAL_RS15895	COG0632	four-way junction helicase activity
SMAL_RS15900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMAL_RS15905	COG0217	transcriptional regulatory protein
SMAL_RS15925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMAL_RS15955	COG0488	(ABC) transporter
SMAL_RS15965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMAL_RS15965	COG4651	solute:proton antiporter activity
SMAL_RS15975	COG0745	RESPONSE REGULATOR receiver
SMAL_RS15980	COG2205	protein histidine kinase activity
SMAL_RS15990	COG0542	response to heat
SMAL_RS16010	COG0028	Belongs to the TPP enzyme family
SMAL_RS16035	COG3387	PFAM Glycoside hydrolase 15-related
SMAL_RS16040	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SMAL_RS16045	COG3011	Protein conserved in bacteria
SMAL_RS16060	COG0564	pseudouridine synthase activity
SMAL_RS16065	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMAL_RS16075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMAL_RS16075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMAL_RS16085	COG0045	succinate-CoA ligase (ADP-forming) activity
SMAL_RS16105	COG0463	Glycosyl transferase, family 2
SMAL_RS16110	COG0438	transferase activity, transferring glycosyl groups
SMAL_RS16120	COG0438	transferase activity, transferring glycosyl groups
SMAL_RS16125	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SMAL_RS16155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SMAL_RS16165	COG2205	protein histidine kinase activity
SMAL_RS16170	COG0745	RESPONSE REGULATOR receiver
SMAL_RS16185	COG0189	ligase activity
SMAL_RS16200	COG3152	Membrane
SMAL_RS16220	COG2022	thiamine diphosphate biosynthetic process
SMAL_RS16225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMAL_RS16230	COG3273	potassium ion transport
SMAL_RS16230	COG0471	metal ion transport
SMAL_RS16250	COG1970	mechanosensitive ion channel activity
SMAL_RS16260	COG1115	amino acid carrier protein
SMAL_RS16270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMAL_RS16275	COG1115	amino acid carrier protein
SMAL_RS16280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMAL_RS16285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL_RS16290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS16310	COG2801	Transposase and inactivated derivatives
SMAL_RS16325	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMAL_RS16335	COG3588	fructose-bisphosphate aldolase
SMAL_RS16340	COG0469	pyruvate kinase activity
SMAL_RS16350	COG0126	phosphoglycerate kinase activity
SMAL_RS16365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMAL_RS16370	COG3047	cAMP biosynthetic process
SMAL_RS16410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMAL_RS16415	COG1301	dicarboxylic acid transport
SMAL_RS16425	COG2304	oxidoreductase activity
SMAL_RS16445	COG0714	Associated with various cellular activities
SMAL_RS16475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMAL_RS16535	COG0254	rRNA binding
SMAL_RS16545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMAL_RS16555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SMAL_RS16560	COG1758	RNA polymerase activity
SMAL_RS16570	COG3383	formate dehydrogenase (NAD+) activity
SMAL_RS16570	COG0243	molybdopterin cofactor binding
SMAL_RS16575	COG3383	formate dehydrogenase (NAD+) activity
SMAL_RS16575	COG0243	molybdopterin cofactor binding
SMAL_RS16580	COG0437	4 iron, 4 sulfur cluster binding
SMAL_RS16585	COG2864	formate dehydrogenase
SMAL_RS16595	COG1921	L-seryl-tRNASec selenium transferase activity
SMAL_RS16600	COG3276	selenocysteine insertion sequence binding
SMAL_RS16610	COG0709	Synthesizes selenophosphate from selenide and ATP
SMAL_RS16615	COG3177	Filamentation induced by cAMP protein fic
SMAL_RS16620	COG1561	YicC-like family, N-terminal region
SMAL_RS16625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SMAL_RS16630	COG0346	lactoylglutathione lyase activity
SMAL_RS16640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMAL_RS16655	COG0006	proline dipeptidase activity
SMAL_RS16660	COG0006	proline dipeptidase activity
SMAL_RS16665	COG3079	Belongs to the UPF0149 family
SMAL_RS16680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMAL_RS16690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMAL_RS16700	COG2912	Transglutaminase-like superfamily
SMAL_RS16705	COG1773	rubredoxin
SMAL_RS16715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMAL_RS16730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMAL_RS16735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMAL_RS16750	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS16770	COG0671	phosphoesterase, PA-phosphatase related
SMAL_RS16780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMAL_RS16785	COG0563	adenylate kinase activity
SMAL_RS16810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SMAL_RS16820	COG0848	biopolymer transport protein
SMAL_RS16830	COG2832	Protein of unknown function (DUF454)
SMAL_RS16865	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMAL_RS16890	COG0745	RESPONSE REGULATOR receiver
SMAL_RS16900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMAL_RS16905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SMAL_RS16910	COG0405	Gamma-glutamyltransferase
SMAL_RS16915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMAL_RS16935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMAL_RS16940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SMAL_RS16955	COG0473	3-isopropylmalate dehydrogenase activity
SMAL_RS16985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMAL_RS16990	COG1538	Outer membrane efflux protein
SMAL_RS16995	COG0531	amino acid
SMAL_RS17000	COG1519	Transferase
SMAL_RS17005	COG1560	Kdo2-lipid A biosynthetic process
SMAL_RS17040	COG1301	dicarboxylic acid transport
SMAL_RS17050	COG4191	Histidine kinase
SMAL_RS17065	COG0642	Histidine kinase
SMAL_RS17080	COG2851	Citrate transporter
SMAL_RS17085	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS17105	COG1162	GTPase activity
SMAL_RS17110	COG0436	Aminotransferase
SMAL_RS17130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SMAL_RS17145	COG1228	amidohydrolase
SMAL_RS17150	COG0804	urea catabolic process
SMAL_RS17160	COG1307	EDD domain protein, DegV family
SMAL_RS17200	COG5001	Diguanylate cyclase
SMAL_RS17200	COG4251	negative regulation of phosphorylation
SMAL_RS17200	COG2203	Gaf domain
SMAL_RS17200	COG3706	GGDEF domain
SMAL_RS17205	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SMAL_RS17215	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SMAL_RS17235	COG1902	pentaerythritol trinitrate reductase activity
SMAL_RS17255	COG0583	DNA-binding transcription factor activity
SMAL_RS17260	COG1064	alcohol dehydrogenase
SMAL_RS17285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMAL_RS17290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMAL_RS17305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SMAL_RS17320	COG1522	sequence-specific DNA binding
SMAL_RS17330	COG4773	Receptor
SMAL_RS17335	COG4206	TonB-dependent receptor
SMAL_RS17355	COG0617	tRNA 3'-terminal CCA addition
SMAL_RS17375	COG3468	outer membrane autotransporter barrel domain protein
SMAL_RS17385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMAL_RS17390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMAL_RS17395	COG1609	Transcriptional regulator
SMAL_RS17405	COG0837	glucose binding
SMAL_RS17415	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SMAL_RS17435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMAL_RS17445	COG4191	Histidine kinase
SMAL_RS17450	COG0784	Response regulator, receiver
SMAL_RS17455	COG4251	negative regulation of phosphorylation
SMAL_RS17460	COG2823	Periplasmic or secreted lipoprotein
SMAL_RS17465	COG0673	inositol 2-dehydrogenase activity
SMAL_RS17470	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SMAL_RS17490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SMAL_RS17495	COG0321	lipoyl(octanoyl) transferase activity
SMAL_RS17500	COG2921	Belongs to the UPF0250 family
SMAL_RS17510	COG1686	Belongs to the peptidase S11 family
SMAL_RS17515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMAL_RS17520	COG2951	lytic endotransglycosylase activity
SMAL_RS17525	COG0772	Belongs to the SEDS family
SMAL_RS17530	COG0772	Belongs to the SEDS family
SMAL_RS17535	COG0768	penicillin binding
SMAL_RS17545	COG1792	Involved in formation and maintenance of cell shape
SMAL_RS17550	COG1077	Cell shape determining protein MreB Mrl
SMAL_RS17555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMAL_RS17560	COG1368	sulfuric ester hydrolase activity
SMAL_RS17565	COG0546	phosphoglycolate phosphatase activity
SMAL_RS17575	COG0308	aminopeptidase N
SMAL_RS17580	COG2226	methyltransferase
SMAL_RS17605	COG1943	Transposase
SMAL_RS17615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL_RS17620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS17630	COG0673	inositol 2-dehydrogenase activity
SMAL_RS17640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMAL_RS17660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMAL_RS17670	COG2832	Protein of unknown function (DUF454)
SMAL_RS17680	COG0436	Aminotransferase
SMAL_RS17685	COG1505	serine-type exopeptidase activity
SMAL_RS17700	COG2011	ABC-type metal ion transport system permease component
SMAL_RS17710	COG0697	spore germination
SMAL_RS17715	COG1666	GTP binding
SMAL_RS17745	COG0339	signal peptide processing
SMAL_RS17755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMAL_RS17775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMAL_RS17785	COG1136	(ABC) transporter
SMAL_RS17790	COG1136	(ABC) transporter
SMAL_RS17790	COG0577	efflux transmembrane transporter activity
SMAL_RS17795	COG0577	efflux transmembrane transporter activity
SMAL_RS17810	COG4191	Histidine kinase
SMAL_RS17820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMAL_RS17830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMAL_RS17835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMAL_RS17840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMAL_RS17845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMAL_RS17850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMAL_RS17855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMAL_RS17865	COG0356	it plays a direct role in the translocation of protons across the membrane
SMAL_RS17880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMAL_RS17885	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMAL_RS17905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMAL_RS17930	COG0181	hydroxymethylbilane synthase activity
SMAL_RS17940	COG2972	Histidine kinase
SMAL_RS17940	COG0745	RESPONSE REGULATOR receiver
SMAL_RS17945	COG0400	carboxylic ester hydrolase activity
SMAL_RS17955	COG4771	TonB-dependent receptor
SMAL_RS17965	COG0840	transmembrane signaling receptor activity
SMAL_RS18005	COG0477	Major facilitator Superfamily
SMAL_RS18035	COG0583	DNA-binding transcription factor activity
SMAL_RS18040	COG0477	Major facilitator Superfamily
SMAL_RS18060	COG4206	TonB-dependent receptor
SMAL_RS18080	COG0625	glutathione transferase activity
SMAL_RS18095	COG2259	Doxx family
SMAL_RS18135	COG3550	peptidyl-serine autophosphorylation
SMAL_RS18140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMAL_RS18145	COG1490	D-aminoacyl-tRNA deacylase activity
SMAL_RS18195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMAL_RS18195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMAL_RS18200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMAL_RS18205	COG0242	peptide deformylase activity
SMAL_RS18215	COG0758	DNA mediated transformation
SMAL_RS18220	COG2922	Belongs to the Smg family
SMAL_RS18230	COG1714	RDD family
SMAL_RS18235	COG1754	DNA topoisomerase type I activity
SMAL_RS18235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMAL_RS18240	COG0009	L-threonylcarbamoyladenylate synthase
SMAL_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS18265	COG0616	signal peptide processing
SMAL_RS18270	COG0534	Mate efflux family protein
SMAL_RS18285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMAL_RS18290	COG0625	glutathione transferase activity
SMAL_RS18300	COG1252	NADH dehydrogenase
SMAL_RS18325	COG2860	membrane
SMAL_RS18335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL_RS18340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL_RS18350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMAL_RS18370	COG1846	Transcriptional regulator
SMAL_RS18395	COG0625	glutathione transferase activity
SMAL_RS18410	COG0459	protein refolding
SMAL_RS18415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMAL_RS18420	COG2356	endonuclease I
SMAL_RS18425	COG1324	tolerance protein
SMAL_RS18435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMAL_RS18445	COG0840	transmembrane signaling receptor activity
SMAL_RS18465	COG0583	DNA-binding transcription factor activity
SMAL_RS18475	COG1785	Belongs to the alkaline phosphatase family
SMAL_RS18485	COG1686	Belongs to the peptidase S11 family
SMAL_RS18495	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMAL_RS18505	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMAL_RS18515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMAL_RS18525	COG0511	ligase activity, forming carbon-carbon bonds
SMAL_RS18530	COG0439	Biotin carboxylase
SMAL_RS18545	COG2264	protein methyltransferase activity
SMAL_RS18555	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
SMAL_RS18560	COG4589	Belongs to the CDS family
SMAL_RS18575	COG0671	phosphoesterase, PA-phosphatase related
SMAL_RS18575	COG2453	phosphatase
SMAL_RS18580	COG2267	carboxylic ester hydrolase activity
SMAL_RS18585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMAL_RS18595	COG0138	bifunctional purine biosynthesis protein purh
SMAL_RS18610	COG0151	Belongs to the GarS family
SMAL_RS18615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMAL_RS18630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMAL_RS18635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMAL_RS18640	COG2201	protein-glutamate methylesterase activity
SMAL_RS18645	COG2177	Part of the ABC transporter FtsEX involved in
SMAL_RS18650	COG2884	Cell division ATP-binding protein ftsE
SMAL_RS18660	COG3118	belongs to the thioredoxin family
SMAL_RS18665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMAL_RS18670	COG3706	GGDEF domain
SMAL_RS18680	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
SMAL_RS18715	COG1652	LysM domain
SMAL_RS18720	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMAL_RS18720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMAL_RS18725	COG1473	amidohydrolase
SMAL_RS18730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS18735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL_RS18750	COG1289	transmembrane transporter activity
SMAL_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS18760	COG2814	Major facilitator Superfamily
SMAL_RS18790	COG0316	Belongs to the HesB IscA family
SMAL_RS18830	COG1051	belongs to the nudix hydrolase family
SMAL_RS18845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMAL_RS18850	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMAL_RS18855	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SMAL_RS18865	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SMAL_RS18870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMAL_RS18875	COG0730	response to heat
SMAL_RS18885	COG0134	indole-3-glycerol-phosphate synthase activity
SMAL_RS18890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMAL_RS18905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMAL_RS18910	COG1597	lipid kinase activity
SMAL_RS18925	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMAL_RS18930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMAL_RS18940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMAL_RS18940	COG2111	Na H antiporter
SMAL_RS18945	COG1006	Multisubunit Na H antiporter MnhC subunit
SMAL_RS18950	COG0651	ATP synthesis coupled electron transport
SMAL_RS18955	COG1863	multisubunit Na H antiporter MnhE subunit
SMAL_RS18960	COG2212	antiporter activity
SMAL_RS18965	COG1320	monovalent cation:proton antiporter activity
SMAL_RS18970	COG0530	calcium, potassium:sodium antiporter activity
SMAL_RS18985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SMAL_RS19000	COG4804	nuclease activity
SMAL_RS19015	COG3104	oligopeptide transport
SMAL_RS19020	COG3483	tryptophan 2,3-dioxygenase activity
SMAL_RS19055	COG2378	regulation of single-species biofilm formation
SMAL_RS19070	COG2354	Protein conserved in bacteria
SMAL_RS19080	COG1368	sulfuric ester hydrolase activity
SMAL_RS19085	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMAL_RS19085	COG3264	Mechanosensitive ion channel
SMAL_RS19100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SMAL_RS19135	COG1166	arginine decarboxylase activity
SMAL_RS19140	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMAL_RS19160	COG2960	long-chain fatty acid transporting porin activity
SMAL_RS19205	COG0606	chelatase, subunit chli
SMAL_RS19220	COG0561	phosphatase activity
SMAL_RS19225	COG3932	Exopolysaccharide synthesis, ExoD
SMAL_RS19250	COG1999	signal sequence binding
SMAL_RS19255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SMAL_RS19260	COG1845	cytochrome c oxidase, subunit III
SMAL_RS19270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMAL_RS19275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMAL_RS19290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMAL_RS19295	COG1104	cysteine desulfurase activity
SMAL_RS19325	COG2031	fatty acid transporter
SMAL_RS19355	COG0673	inositol 2-dehydrogenase activity
SMAL_RS19365	COG1501	Belongs to the glycosyl hydrolase 31 family
SMAL_RS19370	COG2222	sugar isomerase
SMAL_RS19375	COG1940	carbohydrate kinase activity
SMAL_RS19385	COG1349	DNA-binding transcription factor activity
SMAL_RS19390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SMAL_RS19395	COG2814	Major facilitator Superfamily
SMAL_RS19410	COG1040	competence protein
SMAL_RS19435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMAL_RS19440	COG0156	8-amino-7-oxononanoate synthase activity
SMAL_RS19445	COG2267	carboxylic ester hydrolase activity
SMAL_RS19465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMAL_RS19490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMAL_RS19495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMAL_RS19500	COG2205	protein histidine kinase activity
SMAL_RS19505	COG0745	RESPONSE REGULATOR receiver
SMAL_RS19510	COG3541	Predicted nucleotidyltransferase
SMAL_RS19515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMAL_RS19540	COG0714	Associated with various cellular activities
SMAL_RS19550	COG0754	glutathionylspermidine amidase activity
SMAL_RS19560	COG0129	dihydroxy-acid dehydratase activity
SMAL_RS19575	COG1199	ATP-dependent helicase activity
SMAL_RS19585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMAL_RS19605	COG3781	membrane
SMAL_RS19635	COG0625	glutathione transferase activity
SMAL_RS19655	COG2207	Transcriptional regulator
SMAL_RS19670	COG4555	ABC transporter
SMAL_RS19700	COG0633	Ferredoxin
SMAL_RS19700	COG0543	2 iron, 2 sulfur cluster binding
SMAL_RS19705	COG1131	(ABC) transporter
SMAL_RS19710	COG0842	Transport permease protein
SMAL_RS19720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SMAL_RS19730	COG0084	hydrolase, TatD family'
SMAL_RS19735	COG1643	Atp-dependent helicase
SMAL_RS19745	COG1187	pseudouridine synthase activity
SMAL_RS19760	COG0667	Aldo Keto reductase
SMAL_RS19775	COG1690	Belongs to the RtcB family
SMAL_RS19795	COG0583	DNA-binding transcription factor activity
SMAL_RS19800	COG2814	Major facilitator Superfamily
SMAL_RS19805	COG0656	L-ascorbic acid biosynthetic process
SMAL_RS19810	COG2267	carboxylic ester hydrolase activity
SMAL_RS19815	COG0393	Putative heavy-metal-binding
SMAL_RS19820	COG1042	CoA-binding domain protein
SMAL_RS19820	COG0045	succinate-CoA ligase (ADP-forming) activity
SMAL_RS19820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMAL_RS19825	COG2239	Acts as a magnesium transporter
SMAL_RS19835	COG3177	Filamentation induced by cAMP protein fic
SMAL_RS19835	COG0666	response to abiotic stimulus
SMAL_RS19840	COG3100	YcgL domain-containing protein
SMAL_RS19850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMAL_RS19855	COG1028	Short-chain dehydrogenase reductase Sdr
SMAL_RS19875	COG0644	oxidoreductase
SMAL_RS19895	COG2986	histidine ammonia-lyase
SMAL_RS19905	COG0463	Glycosyl transferase, family 2
SMAL_RS19920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMAL_RS19925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMAL_RS19940	COG1294	oxidase, subunit
SMAL_RS19945	COG1271	oxidase subunit
SMAL_RS19965	COG1595	DNA-templated transcription, initiation
SMAL_RS20000	COG0408	coproporphyrinogen oxidase activity
SMAL_RS20010	COG2323	membrane
SMAL_RS20025	COG0589	response to stress
SMAL_RS20040	COG0210	DNA helicase
SMAL_RS20050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMAL_RS20055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMAL_RS20060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMAL_RS20075	COG0251	oxidation-reduction process
SMAL_RS20105	COG2801	Transposase and inactivated derivatives
SMAL_RS20105	COG3415	Transposase
SMAL_RS20115	COG0463	Glycosyl transferase, family 2
SMAL_RS20130	COG1475	DNA binding
SMAL_RS20135	COG1192	Involved in chromosome partitioning
SMAL_RS20140	COG0357	Ribosomal RNA small subunit methyltransferase G
SMAL_RS20145	COG2091	lysine biosynthetic process via aminoadipic acid
SMAL_RS20185	COG1943	Transposase
SMAL_RS20190	COG1971	Probably functions as a manganese efflux pump
SMAL_RS20195	COG2205	protein histidine kinase activity
SMAL_RS20195	COG0784	Response regulator, receiver
SMAL_RS20205	COG2911	Protein conserved in bacteria
SMAL_RS20210	COG0729	surface antigen
SMAL_RS20220	COG0752	glycyl-tRNA synthetase alpha subunit
SMAL_RS20225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMAL_RS20230	COG0519	Catalyzes the synthesis of GMP from XMP
SMAL_RS20230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMAL_RS20240	COG0805	protein transport
SMAL_RS20250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMAL_RS20260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMAL_RS20270	COG0840	transmembrane signaling receptor activity
SMAL_RS20325	COG3135	benzoate transporter
SMAL_RS20340	COG2951	lytic endotransglycosylase activity
SMAL_RS20345	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SMAL_RS20350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SMAL_RS20355	COG3706	GGDEF domain
SMAL_RS20385	COG0302	gtp cyclohydrolase
SMAL_RS20400	COG1566	PFAM secretion protein HlyD family protein
SMAL_RS20410	COG1289	transmembrane transporter activity
SMAL_RS20425	COG1074	ATP-dependent DNA helicase activity
SMAL_RS20430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SMAL_RS20435	COG1127	ABC transporter
SMAL_RS20440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMAL_RS20445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMAL_RS20460	COG2853	Lipoprotein
SMAL_RS20465	COG0386	Belongs to the glutathione peroxidase family
SMAL_RS20475	COG1322	Protein conserved in bacteria
SMAL_RS20510	COG0531	amino acid
SMAL_RS20530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMAL_RS20535	COG0861	Integral membrane protein TerC family
SMAL_RS20545	COG0584	glycerophosphoryl diester phosphodiesterase
SMAL_RS20570	COG0706	membrane insertase activity
SMAL_RS20575	COG0594	ribonuclease P activity
SMAL_RS20580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMAL_RS20635	COG5295	Hep Hag repeat protein