locus-tag	class	description
F0Q13_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0Q13_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0Q13_RS00020	COG0187	DNA topoisomerase II activity
F0Q13_RS00030	COG0501	Belongs to the peptidase M48B family
F0Q13_RS00060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0Q13_RS00140	COG0659	secondary active sulfate transmembrane transporter activity
F0Q13_RS00155	COG0798	PFAM Bile acid sodium symporter
F0Q13_RS00170	COG0431	NADPH-dependent FMN reductase
F0Q13_RS00185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0Q13_RS00205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0Q13_RS00220	COG3453	Protein conserved in bacteria
F0Q13_RS00220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0Q13_RS00240	COG0640	Transcriptional regulator
F0Q13_RS00260	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F0Q13_RS00270	COG4772	TonB-dependent receptor
F0Q13_RS00295	COG0800	Aldolase
F0Q13_RS00310	COG3186	Phenylalanine-4-hydroxylase
F0Q13_RS00315	COG1522	sequence-specific DNA binding
F0Q13_RS00325	COG1752	Esterase of the alpha-beta hydrolase superfamily
F0Q13_RS00355	COG1122	ATPase activity
F0Q13_RS00375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0Q13_RS00380	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F0Q13_RS00395	COG0210	DNA helicase
F0Q13_RS00405	COG3132	Protein of unknown function, DUF480
F0Q13_RS00410	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
F0Q13_RS00415	COG0284	orotidine-5'-phosphate decarboxylase activity
F0Q13_RS00425	COG2937	Belongs to the GPAT DAPAT family
F0Q13_RS00435	COG0037	tRNA processing
F0Q13_RS00440	COG2974	May be involved in recombination
F0Q13_RS00455	COG1803	Methylglyoxal synthase
F0Q13_RS00460	COG2205	protein histidine kinase activity
F0Q13_RS00460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0Q13_RS00465	COG0493	'glutamate synthase
F0Q13_RS00470	COG0067	glutamate synthase
F0Q13_RS00470	COG0069	glutamate synthase activity
F0Q13_RS00470	COG0070	glutamate synthase
F0Q13_RS00490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0Q13_RS00505	COG2814	Major facilitator Superfamily
F0Q13_RS00535	COG1111	helicase
F0Q13_RS00535	COG1205	dead DEAH box helicase
F0Q13_RS00570	COG0714	Associated with various cellular activities
F0Q13_RS00590	COG0312	modulator of DNA gyrase
F0Q13_RS00600	COG3550	peptidyl-serine autophosphorylation
F0Q13_RS00620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F0Q13_RS00640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0Q13_RS00675	COG1968	undecaprenyl-diphosphatase activity
F0Q13_RS00680	COG0174	glutamine synthetase
F0Q13_RS00685	COG0347	Belongs to the P(II) protein family
F0Q13_RS00690	COG0004	ammonium transporteR
F0Q13_RS00700	COG3279	Response regulator of the LytR AlgR family
F0Q13_RS00705	COG2972	Histidine kinase
F0Q13_RS00715	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F0Q13_RS00735	COG3852	Histidine kinase
F0Q13_RS00740	COG2204	response regulator
F0Q13_RS00745	COG2032	superoxide dismutase activity
F0Q13_RS00750	COG2032	superoxide dismutase activity
F0Q13_RS00760	COG0183	Belongs to the thiolase family
F0Q13_RS00795	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F0Q13_RS00800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F0Q13_RS00815	COG3550	peptidyl-serine autophosphorylation
F0Q13_RS00840	COG1401	restriction endodeoxyribonuclease activity
F0Q13_RS00840	COG1401	restriction endodeoxyribonuclease activity
F0Q13_RS00850	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F0Q13_RS00855	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
F0Q13_RS00875	COG2837	iron assimilation
F0Q13_RS00915	COG2197	response regulator
F0Q13_RS00920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0Q13_RS00920	COG2205	protein histidine kinase activity
F0Q13_RS00925	COG3474	cytochrome
F0Q13_RS00935	COG1960	acyl-CoA dehydrogenase activity
F0Q13_RS00940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F0Q13_RS00950	COG0612	Peptidase, M16
F0Q13_RS00960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0Q13_RS00965	COG0596	Alpha beta hydrolase
F0Q13_RS00975	COG0318	PFAM AMP-dependent synthetase and ligase
F0Q13_RS00980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0Q13_RS00990	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0Q13_RS01000	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F0Q13_RS01030	COG0339	signal peptide processing
F0Q13_RS01045	COG0681	Belongs to the peptidase S26 family
F0Q13_RS01050	COG2814	Major facilitator Superfamily
F0Q13_RS01055	COG0583	DNA-binding transcription factor activity
F0Q13_RS01060	COG0583	DNA-binding transcription factor activity
F0Q13_RS01065	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F0Q13_RS01070	COG2224	Isocitrate lyase
F0Q13_RS01075	COG3706	GGDEF domain
F0Q13_RS01100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F0Q13_RS01105	COG1960	acyl-CoA dehydrogenase activity
F0Q13_RS01125	COG0697	spore germination
F0Q13_RS01135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F0Q13_RS01155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0Q13_RS01165	COG1280	lysine exporter protein (LysE YggA)
F0Q13_RS01170	COG1607	acyl-coa hydrolase
F0Q13_RS01180	COG1902	pentaerythritol trinitrate reductase activity
F0Q13_RS01205	COG1335	isochorismatase
F0Q13_RS01210	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0Q13_RS01215	COG1752	Esterase of the alpha-beta hydrolase superfamily
F0Q13_RS01220	COG3800	Transcriptional regulator
F0Q13_RS01220	COG1396	sequence-specific DNA binding
F0Q13_RS01230	COG1960	acyl-CoA dehydrogenase activity
F0Q13_RS01235	COG1024	Enoyl-CoA hydratase
F0Q13_RS01240	COG1024	Enoyl-CoA hydratase
F0Q13_RS01260	COG1764	response to oxidative stress
F0Q13_RS01270	COG0659	secondary active sulfate transmembrane transporter activity
F0Q13_RS01280	COG3657	addiction module killer protein
F0Q13_RS01285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0Q13_RS01295	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS01300	COG2205	protein histidine kinase activity
F0Q13_RS01305	COG3228	Belongs to the MtfA family
F0Q13_RS01315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F0Q13_RS01315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F0Q13_RS01320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F0Q13_RS01385	COG3237	CsbD-like
F0Q13_RS01395	COG0180	Tryptophanyl-tRNA synthetase
F0Q13_RS01420	COG0477	Major facilitator Superfamily
F0Q13_RS01425	COG0697	spore germination
F0Q13_RS01435	COG4771	TonB-dependent receptor
F0Q13_RS01440	COG0577	efflux transmembrane transporter activity
F0Q13_RS01440	COG1136	(ABC) transporter
F0Q13_RS01450	COG1136	(ABC) transporter
F0Q13_RS01455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS01470	COG4585	Histidine kinase
F0Q13_RS01475	COG2197	response regulator
F0Q13_RS01495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0Q13_RS01505	COG0628	permease
F0Q13_RS01525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0Q13_RS01540	COG5507	3-demethylubiquinone-9 3-methyltransferase
F0Q13_RS01545	COG0823	Involved in the tonB-independent uptake of proteins
F0Q13_RS01545	COG1506	peptidase
F0Q13_RS01555	COG2197	response regulator
F0Q13_RS01570	COG2814	Major facilitator Superfamily
F0Q13_RS01575	COG0583	DNA-binding transcription factor activity
F0Q13_RS01580	COG4807	Protein conserved in bacteria
F0Q13_RS01585	COG4221	oxidoreductase activity
F0Q13_RS01600	COG0018	arginyl-trna synthetase
F0Q13_RS01605	COG2003	Belongs to the UPF0758 family
F0Q13_RS01610	COG2197	response regulator
F0Q13_RS01615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F0Q13_RS01620	COG0756	dUTP diphosphatase activity
F0Q13_RS01635	COG2205	protein histidine kinase activity
F0Q13_RS01645	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F0Q13_RS01650	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F0Q13_RS01665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0Q13_RS01670	COG0708	Exodeoxyribonuclease III
F0Q13_RS01675	COG2211	Major facilitator Superfamily
F0Q13_RS01690	COG0739	heme binding
F0Q13_RS01750	COG2234	aminopeptidase activity
F0Q13_RS01760	COG4942	peptidase
F0Q13_RS01765	COG0793	Belongs to the peptidase S41A family
F0Q13_RS01795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F0Q13_RS01840	COG0109	protoheme IX farnesyltransferase activity
F0Q13_RS01860	COG0358	DNA primase activity
F0Q13_RS01865	COG1295	ribonuclease BN
F0Q13_RS01880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0Q13_RS01890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0Q13_RS01895	COG0668	transmembrane transport
F0Q13_RS01910	COG2133	pyrroloquinoline quinone binding
F0Q13_RS01915	COG4682	membrane
F0Q13_RS01925	COG0531	amino acid
F0Q13_RS01935	COG1737	Transcriptional regulator
F0Q13_RS01940	COG4948	Mandelate Racemase Muconate Lactonizing
F0Q13_RS01990	COG5383	Protein conserved in bacteria
F0Q13_RS02000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F0Q13_RS02010	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F0Q13_RS02040	COG0778	Nitroreductase
F0Q13_RS02045	COG2353	YceI-like domain
F0Q13_RS02060	COG2375	cellular response to nickel ion
F0Q13_RS02145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0Q13_RS02185	COG2267	carboxylic ester hydrolase activity
F0Q13_RS02255	COG0583	DNA-binding transcription factor activity
F0Q13_RS02265	COG2814	Major facilitator Superfamily
F0Q13_RS02270	COG4943	cyclic-guanylate-specific phosphodiesterase activity
F0Q13_RS02275	COG1113	amino acid transport
F0Q13_RS02280	COG0741	lytic transglycosylase activity
F0Q13_RS02305	COG2764	glyoxalase bleomycin resistance protein dioxygenase
F0Q13_RS02315	COG5507	3-demethylubiquinone-9 3-methyltransferase
F0Q13_RS02320	COG4941	Belongs to the sigma-70 factor family
F0Q13_RS02405	COG3501	Rhs element vgr protein
F0Q13_RS02485	COG3275	phosphorelay sensor kinase activity
F0Q13_RS02490	COG3279	Response regulator of the LytR AlgR family
F0Q13_RS02510	COG1309	transcriptional regulator
F0Q13_RS02520	COG2814	Major facilitator Superfamily
F0Q13_RS02525	COG3590	peptidase
F0Q13_RS02530	COG5001	Diguanylate cyclase
F0Q13_RS02535	COG0583	DNA-binding transcription factor activity
F0Q13_RS02545	COG3384	dioxygenase
F0Q13_RS02550	COG0025	NhaP-type Na H and K H
F0Q13_RS02575	COG1360	Flagellar Motor Protein
F0Q13_RS02605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0Q13_RS02620	COG2205	protein histidine kinase activity
F0Q13_RS02620	COG0784	Response regulator, receiver
F0Q13_RS02635	COG2813	Specifically methylates the guanine in position
F0Q13_RS02640	COG1187	pseudouridine synthase activity
F0Q13_RS02645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0Q13_RS02655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0Q13_RS02660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0Q13_RS02675	COG0583	DNA-binding transcription factor activity
F0Q13_RS02680	COG2226	methyltransferase
F0Q13_RS02705	COG1956	GAF domain-containing protein
F0Q13_RS02710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0Q13_RS02715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0Q13_RS02720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0Q13_RS02725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0Q13_RS02725	COG0785	Cytochrome C biogenesis protein
F0Q13_RS02730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0Q13_RS02735	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS02740	COG5002	protein histidine kinase activity
F0Q13_RS02745	COG2205	protein histidine kinase activity
F0Q13_RS02750	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS02755	COG0367	asparagine synthase
F0Q13_RS02765	COG0720	synthase
F0Q13_RS02780	COG0513	Belongs to the DEAD box helicase family
F0Q13_RS02790	COG0625	glutathione transferase activity
F0Q13_RS02795	COG1573	uracil-dna glycosylase
F0Q13_RS02830	COG0626	cystathionine gamma-synthase activity
F0Q13_RS02845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0Q13_RS02850	COG0297	glycogen (starch) synthase activity
F0Q13_RS02855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0Q13_RS02920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0Q13_RS02925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0Q13_RS02955	COG1127	ABC transporter
F0Q13_RS02960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0Q13_RS02975	COG0442	prolyl-tRNA aminoacylation
F0Q13_RS02985	COG1183	phosphatidylcholine synthase activity
F0Q13_RS02995	COG0456	acetyltransferase
F0Q13_RS03005	COG0525	valine-tRNA ligase activity
F0Q13_RS03020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0Q13_RS03030	COG0795	lipopolysaccharide-transporting ATPase activity
F0Q13_RS03045	COG4974	Belongs to the 'phage' integrase family
F0Q13_RS03050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0Q13_RS03060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0Q13_RS03060	COG0047	phosphoribosylformylglycinamidine synthase activity
F0Q13_RS03065	COG5295	Hep Hag repeat protein
F0Q13_RS03070	COG1404	Belongs to the peptidase S8 family
F0Q13_RS03075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0Q13_RS03080	COG1459	type II secretion system
F0Q13_RS03085	COG2165	general secretion pathway protein
F0Q13_RS03090	COG4970	Tfp pilus assembly protein FimT
F0Q13_RS03095	COG2165	general secretion pathway protein
F0Q13_RS03100	COG4795	General secretion pathway protein
F0Q13_RS03105	COG3156	type II secretion system protein K
F0Q13_RS03110	COG3166	PFAM Fimbrial assembly family protein
F0Q13_RS03125	COG1450	Type ii and iii secretion system protein
F0Q13_RS03135	COG0463	Glycosyl transferase, family 2
F0Q13_RS03150	COG3539	Fimbrial protein
F0Q13_RS03170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0Q13_RS03180	COG1215	transferase activity, transferring glycosyl groups
F0Q13_RS03195	COG2252	PERMEase
F0Q13_RS03205	COG0488	(ABC) transporter
F0Q13_RS03215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0Q13_RS03230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F0Q13_RS03235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0Q13_RS03235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0Q13_RS03265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F0Q13_RS03270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0Q13_RS03285	COG0277	FAD linked oxidase domain protein
F0Q13_RS03290	COG1988	membrane-bound metal-dependent
F0Q13_RS03325	COG2001	Belongs to the MraZ family
F0Q13_RS03330	COG0275	rRNA processing
F0Q13_RS03335	COG3116	cell division
F0Q13_RS03345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0Q13_RS03350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F0Q13_RS03370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0Q13_RS03375	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0Q13_RS03380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F0Q13_RS03390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F0Q13_RS03395	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F0Q13_RS03405	COG0739	heme binding
F0Q13_RS03410	COG0653	protein targeting
F0Q13_RS03415	COG0494	nUDIX hydrolase
F0Q13_RS03425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F0Q13_RS03435	COG3275	phosphorelay sensor kinase activity
F0Q13_RS03440	COG3279	Response regulator of the LytR AlgR family
F0Q13_RS03445	COG5002	protein histidine kinase activity
F0Q13_RS03445	COG3850	Histidine kinase
F0Q13_RS03450	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS03475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0Q13_RS03480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F0Q13_RS03490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F0Q13_RS03495	COG1607	acyl-coa hydrolase
F0Q13_RS03500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0Q13_RS03520	COG4106	trans-aconitate 2-methyltransferase activity
F0Q13_RS03525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0Q13_RS03535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0Q13_RS03540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0Q13_RS03545	COG0667	Aldo Keto reductase
F0Q13_RS03555	COG4771	TonB-dependent receptor
F0Q13_RS03585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F0Q13_RS03590	COG4181	ATPase activity
F0Q13_RS03605	COG0642	Histidine kinase
F0Q13_RS03615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F0Q13_RS03620	COG0861	Integral membrane protein TerC family
F0Q13_RS03625	COG2814	Major facilitator Superfamily
F0Q13_RS03630	COG1704	LemA family
F0Q13_RS03645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0Q13_RS03650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F0Q13_RS03665	COG3738	Protein conserved in bacteria
F0Q13_RS03670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F0Q13_RS03675	COG2967	ApaG domain
F0Q13_RS03680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F0Q13_RS03685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F0Q13_RS03690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0Q13_RS03695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F0Q13_RS03705	COG2096	Adenosyltransferase
F0Q13_RS03715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0Q13_RS03720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0Q13_RS03725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0Q13_RS03730	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
F0Q13_RS03750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0Q13_RS03760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0Q13_RS03770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0Q13_RS03775	COG0583	DNA-binding transcription factor activity
F0Q13_RS03780	COG3634	alkyl hydroperoxide reductase activity
F0Q13_RS03800	COG0583	DNA-binding transcription factor activity
F0Q13_RS03835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F0Q13_RS03860	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F0Q13_RS03875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0Q13_RS03895	COG1404	Belongs to the peptidase S8 family
F0Q13_RS03915	COG1295	ribonuclease BN
F0Q13_RS03920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0Q13_RS03935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F0Q13_RS03940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F0Q13_RS03955	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F0Q13_RS03965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0Q13_RS03970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F0Q13_RS03975	COG0193	aminoacyl-tRNA hydrolase activity
F0Q13_RS03985	COG0012	GTP binding
F0Q13_RS03990	COG4206	TonB-dependent receptor
F0Q13_RS03995	COG4242	Belongs to the peptidase S51 family
F0Q13_RS04020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0Q13_RS04035	COG0250	Participates in transcription elongation, termination and antitermination
F0Q13_RS04040	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F0Q13_RS04045	COG0081	regulation of translation
F0Q13_RS04050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0Q13_RS04055	COG0222	ribosome binding
F0Q13_RS04060	COG0085	RNA polymerase activity
F0Q13_RS04065	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F0Q13_RS04070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F0Q13_RS04075	COG0049	tRNA binding
F0Q13_RS04080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0Q13_RS04085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0Q13_RS04090	COG0051	transcription antitermination factor activity, RNA binding
F0Q13_RS04095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0Q13_RS04100	COG0088	Forms part of the polypeptide exit tunnel
F0Q13_RS04105	COG0089	rRNA binding
F0Q13_RS04110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F0Q13_RS04115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0Q13_RS04120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F0Q13_RS04125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0Q13_RS04130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0Q13_RS04135	COG0255	Belongs to the universal ribosomal protein uL29 family
F0Q13_RS04140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F0Q13_RS04145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F0Q13_RS04150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F0Q13_RS04155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F0Q13_RS04160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0Q13_RS04165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F0Q13_RS04170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F0Q13_RS04175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0Q13_RS04180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0Q13_RS04185	COG1841	ribosomal large subunit assembly
F0Q13_RS04190	COG0200	Binds to the 23S rRNA
F0Q13_RS04195	COG0201	protein transport
F0Q13_RS04200	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0Q13_RS04205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0Q13_RS04210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0Q13_RS04215	COG0202	RNA polymerase activity
F0Q13_RS04220	COG0203	ribosomal protein L17
F0Q13_RS04235	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F0Q13_RS04245	COG0154	amidase activity
F0Q13_RS04260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0Q13_RS04265	COG0039	L-malate dehydrogenase activity
F0Q13_RS04270	COG0564	pseudouridine synthase activity
F0Q13_RS04275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0Q13_RS04290	COG0625	glutathione transferase activity
F0Q13_RS04300	COG1902	pentaerythritol trinitrate reductase activity
F0Q13_RS04300	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0Q13_RS04305	COG2364	Membrane
F0Q13_RS04315	COG0604	alcohol dehydrogenase
F0Q13_RS04330	COG1187	pseudouridine synthase activity
F0Q13_RS04350	COG1063	alcohol dehydrogenase
F0Q13_RS04360	COG0588	phosphoglycerate mutase activity
F0Q13_RS04365	COG0285	dihydrofolate synthase activity
F0Q13_RS04385	COG2833	Protein of unknown function (DUF455)
F0Q13_RS04395	COG3291	Pkd domain containing protein
F0Q13_RS04400	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0Q13_RS04410	COG0438	transferase activity, transferring glycosyl groups
F0Q13_RS04415	COG4771	TonB-dependent receptor
F0Q13_RS04420	COG4206	TonB-dependent receptor
F0Q13_RS04425	COG0248	Ppx GppA phosphatase
F0Q13_RS04430	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F0Q13_RS04445	COG4783	chaperone-mediated protein folding
F0Q13_RS04460	COG0473	3-isopropylmalate dehydrogenase activity
F0Q13_RS04540	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F0Q13_RS04580	COG0592	DNA-directed DNA polymerase activity
F0Q13_RS04765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0Q13_RS04765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0Q13_RS04830	COG0544	peptidyl-prolyl cis-trans isomerase activity
F0Q13_RS04835	COG0740	serine-type endopeptidase activity
F0Q13_RS04840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0Q13_RS04880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0Q13_RS04885	COG3942	CHAP domain
F0Q13_RS04885	COG1388	LysM domain
F0Q13_RS04890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0Q13_RS04900	COG0328	RNA-DNA hybrid ribonuclease activity
F0Q13_RS04905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0Q13_RS04910	COG0631	protein serine/threonine phosphatase activity
F0Q13_RS04930	COG0859	PFAM glycosyl transferase family 9
F0Q13_RS04935	COG3642	lipopolysaccharide core region biosynthetic process
F0Q13_RS04940	COG1234	tRNA 3'-trailer cleavage
F0Q13_RS04955	COG2076	Multidrug Resistance protein
F0Q13_RS04980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F0Q13_RS04985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F0Q13_RS04995	COG0537	adenosine 5'-monophosphoramidase activity
F0Q13_RS05015	COG0714	Associated with various cellular activities
F0Q13_RS05030	COG1399	metal-binding, possibly nucleic acid-binding protein
F0Q13_RS05035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F0Q13_RS05040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0Q13_RS05050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F0Q13_RS05055	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS05065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0Q13_RS05070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F0Q13_RS05075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0Q13_RS05080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0Q13_RS05115	COG4774	siderophore transport
F0Q13_RS05125	COG2223	nitrite transmembrane transporter activity
F0Q13_RS05150	COG0583	DNA-binding transcription factor activity
F0Q13_RS05155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0Q13_RS05160	COG0697	spore germination
F0Q13_RS05170	COG0477	Major facilitator Superfamily
F0Q13_RS05180	COG2205	protein histidine kinase activity
F0Q13_RS05190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS05235	COG0583	DNA-binding transcription factor activity
F0Q13_RS05245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F0Q13_RS05260	COG0667	Aldo Keto reductase
F0Q13_RS05285	COG2818	Glycosylase
F0Q13_RS05290	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
F0Q13_RS05295	COG1678	Uncharacterized ACR, COG1678
F0Q13_RS05300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0Q13_RS05305	COG0540	Belongs to the ATCase OTCase family
F0Q13_RS05325	COG2239	Acts as a magnesium transporter
F0Q13_RS05330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0Q13_RS05345	COG1660	Displays ATPase and GTPase activities
F0Q13_RS05350	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F0Q13_RS05355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0Q13_RS05360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0Q13_RS05370	COG1137	ATPase activity
F0Q13_RS05385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F0Q13_RS05400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0Q13_RS05420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F0Q13_RS05440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0Q13_RS05450	COG0628	permease
F0Q13_RS05460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F0Q13_RS05470	COG2261	transglycosylase associated protein
F0Q13_RS05480	COG1555	photosystem II stabilization
F0Q13_RS05500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0Q13_RS05505	COG1477	protein flavinylation
F0Q13_RS05525	COG4771	TonB-dependent receptor
F0Q13_RS05535	COG3128	pkhd-type hydroxylase
F0Q13_RS05545	COG4774	siderophore transport
F0Q13_RS05600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0Q13_RS05605	COG0719	Fe-S assembly protein
F0Q13_RS05610	COG0396	ATPase activity
F0Q13_RS05615	COG0719	Fe-S assembly protein
F0Q13_RS05620	COG1959	2 iron, 2 sulfur cluster binding
F0Q13_RS05650	COG1764	response to oxidative stress
F0Q13_RS05655	COG0384	phenazine biosynthesis protein PhzF
F0Q13_RS05660	COG0384	phenazine biosynthesis protein PhzF
F0Q13_RS05665	COG0527	aspartate kinase activity
F0Q13_RS05675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F0Q13_RS05690	COG0142	geranyltranstransferase activity
F0Q13_RS05695	COG0366	Alpha amylase catalytic
F0Q13_RS05705	COG1082	Xylose isomerase domain protein TIM barrel
F0Q13_RS05715	COG2190	(PTS) system
F0Q13_RS05715	COG2211	Major facilitator Superfamily
F0Q13_RS05745	COG1131	(ABC) transporter
F0Q13_RS05760	COG0629	single-stranded DNA binding
F0Q13_RS05785	COG2010	Cytochrome c
F0Q13_RS05795	COG0673	inositol 2-dehydrogenase activity
F0Q13_RS05800	COG2211	Major facilitator Superfamily
F0Q13_RS05810	COG1609	Transcriptional regulator
F0Q13_RS05820	COG0583	DNA-binding transcription factor activity
F0Q13_RS05860	COG3655	Transcriptional regulator
F0Q13_RS05865	COG1253	flavin adenine dinucleotide binding
F0Q13_RS05870	COG1408	metallophosphoesterase
F0Q13_RS05885	COG0477	Major facilitator Superfamily
F0Q13_RS05900	COG1802	Transcriptional regulator
F0Q13_RS05935	COG3052	prosthetic group binding
F0Q13_RS05950	COG0579	oxidoreductase
F0Q13_RS05980	COG3104	oligopeptide transport
F0Q13_RS05990	COG1297	OPT oligopeptide transporter protein
F0Q13_RS05995	COG1506	peptidase
F0Q13_RS05995	COG0823	Involved in the tonB-independent uptake of proteins
F0Q13_RS06010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F0Q13_RS06015	COG2894	cell division
F0Q13_RS06030	COG4585	Histidine kinase
F0Q13_RS06035	COG2197	response regulator
F0Q13_RS06075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
F0Q13_RS06085	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
F0Q13_RS06095	COG1595	DNA-templated transcription, initiation
F0Q13_RS06105	COG1946	Acyl-CoA thioesterase
F0Q13_RS06125	COG0824	Thioesterase
F0Q13_RS06130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0Q13_RS06135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F0Q13_RS06140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F0Q13_RS06145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0Q13_RS06150	COG0268	Binds directly to 16S ribosomal RNA
F0Q13_RS06160	COG0196	riboflavin kinase activity
F0Q13_RS06165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F0Q13_RS06175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F0Q13_RS06200	COG4206	TonB-dependent receptor
F0Q13_RS06220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0Q13_RS06235	COG3209	COG3209 Rhs family protein
F0Q13_RS06255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F0Q13_RS06260	COG1845	cytochrome c oxidase, subunit III
F0Q13_RS06265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F0Q13_RS06280	COG0326	Molecular chaperone. Has ATPase activity
F0Q13_RS06300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F0Q13_RS06315	COG0228	four-way junction DNA binding
F0Q13_RS06320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F0Q13_RS06325	COG0336	Belongs to the RNA methyltransferase TrmD family
F0Q13_RS06330	COG0335	large ribosomal subunit rRNA binding
F0Q13_RS06350	COG0534	Mate efflux family protein
F0Q13_RS06375	COG0753	catalase activity
F0Q13_RS06400	COG0840	transmembrane signaling receptor activity
F0Q13_RS06420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS06445	COG0024	Methionine aminopeptidase
F0Q13_RS06500	COG1647	Serine aminopeptidase, S33
F0Q13_RS06525	COG2814	Major facilitator Superfamily
F0Q13_RS06530	COG3706	GGDEF domain
F0Q13_RS06550	COG0588	phosphoglycerate mutase activity
F0Q13_RS06555	COG3590	peptidase
F0Q13_RS06565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F0Q13_RS06575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F0Q13_RS06580	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS06585	COG2205	protein histidine kinase activity
F0Q13_RS06590	COG4452	Inner membrane protein CreD
F0Q13_RS06605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0Q13_RS06610	COG0735	belongs to the Fur family
F0Q13_RS06660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0Q13_RS06700	COG5002	protein histidine kinase activity
F0Q13_RS06700	COG5001	Diguanylate cyclase
F0Q13_RS06710	COG1187	pseudouridine synthase activity
F0Q13_RS06715	COG3706	GGDEF domain
F0Q13_RS06720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0Q13_RS06740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0Q13_RS06745	COG1132	(ABC) transporter
F0Q13_RS06790	COG1695	Transcriptional regulator
F0Q13_RS06815	COG0825	malonyl-CoA metabolic process
F0Q13_RS06840	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0Q13_RS06850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0Q13_RS06855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0Q13_RS06860	COG0750	zinc metalloprotease
F0Q13_RS06865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F0Q13_RS06870	COG0575	Belongs to the CDS family
F0Q13_RS06875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0Q13_RS06880	COG0233	cytoplasmic translational termination
F0Q13_RS06885	COG0528	UMP kinase activity
F0Q13_RS06890	COG3706	GGDEF domain
F0Q13_RS06895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F0Q13_RS06900	COG0052	Belongs to the universal ribosomal protein uS2 family
F0Q13_RS06920	COG3188	usher protein
F0Q13_RS06940	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F0Q13_RS06955	COG1393	Belongs to the ArsC family
F0Q13_RS06960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0Q13_RS06970	COG0367	asparagine synthase
F0Q13_RS06975	COG0475	glutathione-regulated potassium exporter activity
F0Q13_RS07010	COG1566	PFAM secretion protein HlyD family protein
F0Q13_RS07015	COG2814	Major facilitator Superfamily
F0Q13_RS07030	COG0583	DNA-binding transcription factor activity
F0Q13_RS07050	COG0557	exoribonuclease II activity
F0Q13_RS07060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0Q13_RS07065	COG1538	Outer membrane efflux protein
F0Q13_RS07070	COG0577	efflux transmembrane transporter activity
F0Q13_RS07070	COG1136	(ABC) transporter
F0Q13_RS07075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS07080	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS07085	COG2205	protein histidine kinase activity
F0Q13_RS07090	COG3706	GGDEF domain
F0Q13_RS07100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0Q13_RS07105	COG2259	Doxx family
F0Q13_RS07115	COG3220	belongs to the UPF0276 family
F0Q13_RS07125	COG0704	Plays a role in the regulation of phosphate uptake
F0Q13_RS07135	COG0581	inorganic phosphate transmembrane transporter activity
F0Q13_RS07140	COG0573	inorganic phosphate transmembrane transporter activity
F0Q13_RS07145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0Q13_RS07150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0Q13_RS07160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F0Q13_RS07170	COG1024	Enoyl-CoA hydratase
F0Q13_RS07180	COG0494	nUDIX hydrolase
F0Q13_RS07200	COG0116	Belongs to the methyltransferase superfamily
F0Q13_RS07200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0Q13_RS07225	COG2733	membrane
F0Q13_RS07240	COG1012	belongs to the aldehyde dehydrogenase family
F0Q13_RS07250	COG0477	Major facilitator Superfamily
F0Q13_RS07255	COG2703	oxygen carrier activity
F0Q13_RS07280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0Q13_RS07290	COG0174	glutamine synthetase
F0Q13_RS07300	COG2072	flavoprotein involved in K transport
F0Q13_RS07305	COG3842	ATPase activity
F0Q13_RS07310	COG1176	ABC-type spermidine putrescine transport system, permease component I
F0Q13_RS07315	COG1177	transmembrane transport
F0Q13_RS07320	COG1012	belongs to the aldehyde dehydrogenase family
F0Q13_RS07335	COG4535	Mg2 and Co2 transporter CorC
F0Q13_RS07350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0Q13_RS07355	COG1702	phosphate starvation-inducible protein PhoH
F0Q13_RS07360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS07365	COG0842	Transport permease protein
F0Q13_RS07365	COG1129	ABC transporter
F0Q13_RS07370	COG0842	Transport permease protein
F0Q13_RS07375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0Q13_RS07390	COG0741	lytic transglycosylase activity
F0Q13_RS07395	COG0723	plastoquinol--plastocyanin reductase activity
F0Q13_RS07400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F0Q13_RS07405	COG2857	Cytochrome c1
F0Q13_RS07410	COG0625	glutathione transferase activity
F0Q13_RS07415	COG2969	positive regulation of protein catabolic process
F0Q13_RS07450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0Q13_RS07460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F0Q13_RS07475	COG1611	Belongs to the LOG family
F0Q13_RS07520	COG0556	nucleotide-excision repair
F0Q13_RS07550	COG3713	MltA-interacting MipA family protein
F0Q13_RS07560	COG2205	protein histidine kinase activity
F0Q13_RS07565	COG0658	competence protein
F0Q13_RS07565	COG2333	competence protein COMEC
F0Q13_RS07570	COG0811	peptide transport
F0Q13_RS07575	COG0848	biopolymer transport protein
F0Q13_RS07585	COG1663	tetraacyldisaccharide 4'-kinase activity
F0Q13_RS07590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F0Q13_RS07595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0Q13_RS07605	COG0322	excinuclease ABC activity
F0Q13_RS07645	COG0577	efflux transmembrane transporter activity
F0Q13_RS07645	COG1136	(ABC) transporter
F0Q13_RS07690	COG0456	acetyltransferase
F0Q13_RS07690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0Q13_RS07695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F0Q13_RS07730	COG1917	Cupin 2, conserved barrel domain protein
F0Q13_RS07730	COG4977	sequence-specific DNA binding
F0Q13_RS07735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0Q13_RS07770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0Q13_RS07785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F0Q13_RS07790	COG0069	glutamate synthase activity
F0Q13_RS07800	COG0644	oxidoreductase
F0Q13_RS07820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0Q13_RS07835	COG1253	flavin adenine dinucleotide binding
F0Q13_RS07855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0Q13_RS07870	COG0504	CTP synthase activity
F0Q13_RS07875	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F0Q13_RS07890	COG0148	phosphopyruvate hydratase activity
F0Q13_RS07895	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F0Q13_RS07900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F0Q13_RS07905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F0Q13_RS07915	COG2840	Smr protein MutS2
F0Q13_RS07920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F0Q13_RS07925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0Q13_RS07950	COG1534	Rna-binding protein
F0Q13_RS07955	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F0Q13_RS07960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F0Q13_RS07970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F0Q13_RS07975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0Q13_RS07980	COG1923	regulation of RNA biosynthetic process
F0Q13_RS07985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0Q13_RS07990	COG1546	Belongs to the CinA family
F0Q13_RS07995	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F0Q13_RS08000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0Q13_RS08005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F0Q13_RS08010	COG2137	regulation of response to DNA damage stimulus
F0Q13_RS08015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0Q13_RS08020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F0Q13_RS08045	COG4773	Receptor
F0Q13_RS08080	COG3540	Alkaline phosphatase
F0Q13_RS08100	COG3258	Cytochrome c
F0Q13_RS08115	COG2223	nitrite transmembrane transporter activity
F0Q13_RS08130	COG1741	Belongs to the pirin family
F0Q13_RS08135	COG0583	DNA-binding transcription factor activity
F0Q13_RS08160	COG0352	thiamine-phosphate diphosphorylase activity
F0Q13_RS08160	COG0351	phosphomethylpyrimidine kinase
F0Q13_RS08175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F0Q13_RS08180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F0Q13_RS08190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0Q13_RS08200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F0Q13_RS08205	COG0477	Major facilitator Superfamily
F0Q13_RS08220	COG0617	tRNA 3'-terminal CCA addition
F0Q13_RS08230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F0Q13_RS08235	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F0Q13_RS08245	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F0Q13_RS08250	COG0166	Belongs to the GPI family
F0Q13_RS08265	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
F0Q13_RS08275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F0Q13_RS08280	COG0671	phosphoesterase, PA-phosphatase related
F0Q13_RS08290	COG0800	Aldolase
F0Q13_RS08295	COG0129	dihydroxy-acid dehydratase activity
F0Q13_RS08305	COG0837	glucose binding
F0Q13_RS08310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F0Q13_RS08330	COG2009	succinate dehydrogenase
F0Q13_RS08335	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F0Q13_RS08340	COG1053	succinate dehydrogenase
F0Q13_RS08360	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0Q13_RS08375	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F0Q13_RS08385	COG0552	protein localization to endoplasmic reticulum
F0Q13_RS08400	COG0742	ribosomal rna small subunit methyltransferase
F0Q13_RS08405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F0Q13_RS08415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0Q13_RS08420	COG0405	Gamma-glutamyltransferase
F0Q13_RS08425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0Q13_RS08435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F0Q13_RS08455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F0Q13_RS08465	COG0415	Belongs to the DNA photolyase family
F0Q13_RS08470	COG2885	chlorophyll binding
F0Q13_RS08480	COG0583	DNA-binding transcription factor activity
F0Q13_RS08580	COG1404	Belongs to the peptidase S8 family
F0Q13_RS08605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F0Q13_RS08615	COG2914	Belongs to the UPF0125 (RnfH) family
F0Q13_RS08620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0Q13_RS08625	COG0735	belongs to the Fur family
F0Q13_RS08635	COG0583	DNA-binding transcription factor activity
F0Q13_RS08640	COG0497	DNA recombination
F0Q13_RS08645	COG1420	regulation of RNA biosynthetic process
F0Q13_RS08650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0Q13_RS08655	COG0443	Heat shock 70 kDa protein
F0Q13_RS08660	COG0484	heat shock protein binding
F0Q13_RS08675	COG2207	Transcriptional regulator
F0Q13_RS08680	COG2223	nitrite transmembrane transporter activity
F0Q13_RS08690	COG1605	Chorismate mutase
F0Q13_RS08690	COG0287	Prephenate dehydrogenase
F0Q13_RS08700	COG1132	(ABC) transporter
F0Q13_RS08730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F0Q13_RS08735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F0Q13_RS08740	COG0343	queuine tRNA-ribosyltransferase activity
F0Q13_RS08745	COG1862	Preprotein translocase
F0Q13_RS08755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0Q13_RS08760	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0Q13_RS08770	COG2081	HI0933 family
F0Q13_RS08775	COG4681	YaeQ
F0Q13_RS08780	COG0564	pseudouridine synthase activity
F0Q13_RS08795	COG0625	glutathione transferase activity
F0Q13_RS08800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F0Q13_RS08805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0Q13_RS08810	COG0513	Belongs to the DEAD box helicase family
F0Q13_RS08820	COG0583	DNA-binding transcription factor activity
F0Q13_RS08870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS08885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0Q13_RS08890	COG2957	Belongs to the agmatine deiminase family
F0Q13_RS08900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0Q13_RS08905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0Q13_RS08915	COG0776	regulation of translation
F0Q13_RS08925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F0Q13_RS08940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F0Q13_RS08945	COG0183	Belongs to the thiolase family
F0Q13_RS08950	COG1024	Enoyl-CoA hydratase
F0Q13_RS08950	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0Q13_RS08960	COG0105	UTP biosynthetic process
F0Q13_RS08965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F0Q13_RS08980	COG2976	Protein conserved in bacteria
F0Q13_RS08985	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0Q13_RS08990	COG1160	GTP binding
F0Q13_RS09010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0Q13_RS09015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0Q13_RS09015	COG0475	glutathione-regulated potassium exporter activity
F0Q13_RS09030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0Q13_RS09030	COG0519	Catalyzes the synthesis of GMP from XMP
F0Q13_RS09050	COG0583	DNA-binding transcription factor activity
F0Q13_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS09090	COG0640	Transcriptional regulator
F0Q13_RS09105	COG4716	Myosin-crossreactive antigen
F0Q13_RS09125	COG0431	NADPH-dependent FMN reductase
F0Q13_RS09135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0Q13_RS09140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0Q13_RS09145	COG1473	amidohydrolase
F0Q13_RS09180	COG4943	cyclic-guanylate-specific phosphodiesterase activity
F0Q13_RS09185	COG0583	DNA-binding transcription factor activity
F0Q13_RS09190	COG0477	Major facilitator Superfamily
F0Q13_RS09195	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS09205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0Q13_RS09225	COG1309	transcriptional regulator
F0Q13_RS09240	COG0697	spore germination
F0Q13_RS09245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F0Q13_RS09250	COG0167	dihydroorotate dehydrogenase activity
F0Q13_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS09270	COG1012	belongs to the aldehyde dehydrogenase family
F0Q13_RS09280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0Q13_RS09285	COG0489	protein tyrosine kinase activity
F0Q13_RS09285	COG3206	protein involved in exopolysaccharide biosynthesis
F0Q13_RS09320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0Q13_RS09355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0Q13_RS09385	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS09390	COG4191	Histidine kinase
F0Q13_RS09390	COG0784	Response regulator, receiver
F0Q13_RS09395	COG2205	protein histidine kinase activity
F0Q13_RS09395	COG3437	response regulator, receiver
F0Q13_RS09395	COG3850	Histidine kinase
F0Q13_RS09395	COG4999	Histidine kinase
F0Q13_RS09400	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0Q13_RS09410	COG5002	protein histidine kinase activity
F0Q13_RS09420	COG0640	Transcriptional regulator
F0Q13_RS09460	COG0527	aspartate kinase activity
F0Q13_RS09460	COG0460	homoserine dehydrogenase
F0Q13_RS09465	COG0083	homoserine kinase activity
F0Q13_RS09475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0Q13_RS09480	COG0124	histidyl-tRNA synthetase
F0Q13_RS09495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0Q13_RS09500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F0Q13_RS09505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0Q13_RS09510	COG0131	Imidazoleglycerol-phosphate dehydratase
F0Q13_RS09510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0Q13_RS09515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F0Q13_RS09520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0Q13_RS09525	COG0107	imidazoleglycerol-phosphate synthase activity
F0Q13_RS09530	COG0140	phosphoribosyl-ATP diphosphatase activity
F0Q13_RS09530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F0Q13_RS09550	COG1446	asparaginase
F0Q13_RS09555	COG3142	Participates in the control of copper homeostasis
F0Q13_RS09575	COG0789	Transcriptional regulator
F0Q13_RS09590	COG3537	Alpha-1,2-mannosidase
F0Q13_RS09595	COG1609	Transcriptional regulator
F0Q13_RS09605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0Q13_RS09625	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
F0Q13_RS09630	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
F0Q13_RS09635	COG0235	Class ii aldolase
F0Q13_RS09640	COG0531	amino acid
F0Q13_RS09645	COG0531	amino acid
F0Q13_RS09660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0Q13_RS09665	COG0277	FAD linked oxidase domain protein
F0Q13_RS09680	COG2205	protein histidine kinase activity
F0Q13_RS09685	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS09690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS09695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS09715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0Q13_RS09735	COG1024	Enoyl-CoA hydratase
F0Q13_RS09760	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0Q13_RS09770	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS09775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0Q13_RS09780	COG0505	Belongs to the CarA family
F0Q13_RS09785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0Q13_RS09790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0Q13_RS09800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F0Q13_RS09810	COG4676	Protein conserved in bacteria
F0Q13_RS09820	COG0671	phosphoesterase, PA-phosphatase related
F0Q13_RS09830	COG3279	Response regulator of the LytR AlgR family
F0Q13_RS09845	COG1012	belongs to the aldehyde dehydrogenase family
F0Q13_RS09855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F0Q13_RS09870	COG2198	Histidine kinase
F0Q13_RS09870	COG0784	Response regulator, receiver
F0Q13_RS09870	COG2205	protein histidine kinase activity
F0Q13_RS09875	COG1024	Enoyl-CoA hydratase
F0Q13_RS09880	COG0318	PFAM AMP-dependent synthetase and ligase
F0Q13_RS09885	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F0Q13_RS09890	COG1012	belongs to the aldehyde dehydrogenase family
F0Q13_RS09895	COG1309	transcriptional regulator
F0Q13_RS09900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0Q13_RS09930	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
F0Q13_RS09945	COG0840	transmembrane signaling receptor activity
F0Q13_RS09955	COG0835	chemotaxis
F0Q13_RS09960	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
F0Q13_RS09965	COG0840	transmembrane signaling receptor activity
F0Q13_RS09975	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS09985	COG0835	chemotaxis
F0Q13_RS09995	COG1360	Flagellar Motor Protein
F0Q13_RS10000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F0Q13_RS10005	COG0784	Response regulator, receiver
F0Q13_RS10005	COG0643	Histidine kinase
F0Q13_RS10005	COG2198	Histidine kinase
F0Q13_RS10010	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
F0Q13_RS10035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F0Q13_RS10040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F0Q13_RS10055	COG1987	bacterial-type flagellum assembly
F0Q13_RS10065	COG3190	flagellar
F0Q13_RS10115	COG1677	Flagellar hook-basal body complex protein FliE
F0Q13_RS10140	COG2197	response regulator
F0Q13_RS10195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F0Q13_RS10205	COG4787	bacterial-type flagellum-dependent cell motility
F0Q13_RS10220	COG1558	bacterial-type flagellum-dependent cell motility
F0Q13_RS10225	COG1815	bacterial-type flagellum-dependent cell motility
F0Q13_RS10230	COG0835	chemotaxis
F0Q13_RS10230	COG0784	Response regulator, receiver
F0Q13_RS10250	COG5002	protein histidine kinase activity
F0Q13_RS10295	COG2915	High frequency lysogenization protein hflD homolog
F0Q13_RS10300	COG0482	sulfurtransferase activity
F0Q13_RS10315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F0Q13_RS10325	COG0542	response to heat
F0Q13_RS10360	COG0492	ferredoxin-NADP+ reductase activity
F0Q13_RS10365	COG1674	ftsk spoiiie
F0Q13_RS10380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F0Q13_RS10395	COG2819	hydrolase of the alpha beta superfamily
F0Q13_RS10405	COG4558	Periplasmic binding protein
F0Q13_RS10410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0Q13_RS10415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0Q13_RS10430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0Q13_RS10445	COG0784	Response regulator, receiver
F0Q13_RS10445	COG5002	protein histidine kinase activity
F0Q13_RS10450	COG2197	response regulator
F0Q13_RS10480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0Q13_RS10490	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F0Q13_RS10505	COG1595	DNA-templated transcription, initiation
F0Q13_RS10525	COG0784	Response regulator, receiver
F0Q13_RS10530	COG4251	negative regulation of phosphorylation
F0Q13_RS10540	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
F0Q13_RS10670	COG0789	Transcriptional regulator
F0Q13_RS10675	COG2608	mercury ion transmembrane transporter activity
F0Q13_RS10680	COG2608	mercury ion transmembrane transporter activity
F0Q13_RS10690	COG0789	Transcriptional regulator
F0Q13_RS10725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F0Q13_RS10755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F0Q13_RS10760	COG4644	lycopene metabolic process
F0Q13_RS10780	COG0697	spore germination
F0Q13_RS10835	COG2217	Heavy metal translocating P-type atpase
F0Q13_RS10850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS10855	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS10870	COG0010	Belongs to the arginase family
F0Q13_RS10925	COG2132	Multicopper oxidase
F0Q13_RS10950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0Q13_RS11005	COG4644	lycopene metabolic process
F0Q13_RS11035	COG0583	DNA-binding transcription factor activity
F0Q13_RS11065	COG1309	transcriptional regulator
F0Q13_RS11180	COG1309	transcriptional regulator
F0Q13_RS11240	COG1609	Transcriptional regulator
F0Q13_RS11245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0Q13_RS11245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0Q13_RS11250	COG1105	Belongs to the carbohydrate kinase PfkB family
F0Q13_RS11255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0Q13_RS11255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0Q13_RS11280	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F0Q13_RS11285	COG0583	DNA-binding transcription factor activity
F0Q13_RS11300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F0Q13_RS11325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0Q13_RS11330	COG5265	(ABC) transporter
F0Q13_RS11350	COG4555	ABC transporter
F0Q13_RS11375	COG2207	Transcriptional regulator
F0Q13_RS11400	COG0642	Histidine kinase
F0Q13_RS11410	COG0318	PFAM AMP-dependent synthetase and ligase
F0Q13_RS11420	COG2186	Transcriptional regulator
F0Q13_RS11440	COG2271	Major facilitator Superfamily
F0Q13_RS11445	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS11485	COG0583	DNA-binding transcription factor activity
F0Q13_RS11490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0Q13_RS11510	COG0583	DNA-binding transcription factor activity
F0Q13_RS11535	COG2204	response regulator
F0Q13_RS11610	COG5002	protein histidine kinase activity
F0Q13_RS11610	COG3447	MASE1 domain protein
F0Q13_RS11610	COG5001	Diguanylate cyclase
F0Q13_RS11615	COG0577	efflux transmembrane transporter activity
F0Q13_RS11615	COG1136	(ABC) transporter
F0Q13_RS11620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS11630	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS11635	COG2205	protein histidine kinase activity
F0Q13_RS11655	COG4774	siderophore transport
F0Q13_RS11675	COG3214	Protein conserved in bacteria
F0Q13_RS11685	COG4774	siderophore transport
F0Q13_RS11710	COG3188	usher protein
F0Q13_RS11735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0Q13_RS11740	COG1285	pathogenesis
F0Q13_RS11745	COG4191	Histidine kinase
F0Q13_RS11750	COG4566	intracellular signal transduction
F0Q13_RS11800	COG0243	molybdopterin cofactor binding
F0Q13_RS11805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F0Q13_RS11850	COG1136	(ABC) transporter
F0Q13_RS11865	COG4771	TonB-dependent receptor
F0Q13_RS11895	COG0583	DNA-binding transcription factor activity
F0Q13_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS11930	COG0642	Histidine kinase
F0Q13_RS11935	COG3537	Alpha-1,2-mannosidase
F0Q13_RS11940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0Q13_RS11955	COG0477	Major facilitator Superfamily
F0Q13_RS11975	COG2202	Pas domain
F0Q13_RS11975	COG3920	Histidine kinase
F0Q13_RS12020	COG1335	isochorismatase
F0Q13_RS12025	COG1335	isochorismatase
F0Q13_RS12060	COG0811	peptide transport
F0Q13_RS12135	COG3451	type IV secretory pathway VirB4
F0Q13_RS12145	COG3838	Conjugal transfer protein Trbc
F0Q13_RS12150	COG4962	Type ii secretion system protein e
F0Q13_RS12170	COG0583	DNA-binding transcription factor activity
F0Q13_RS12180	COG2226	methyltransferase
F0Q13_RS12200	COG0701	Predicted permease
F0Q13_RS12205	COG1695	Transcriptional regulator
F0Q13_RS12215	COG4959	Type IV secretory pathway protease TraF
F0Q13_RS12230	COG1192	Involved in chromosome partitioning
F0Q13_RS12270	COG5489	Protein of unknown function (DUF736)
F0Q13_RS12305	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F0Q13_RS12410	COG0840	transmembrane signaling receptor activity
F0Q13_RS12415	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0Q13_RS12420	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F0Q13_RS12425	COG4149	molybdate abc transporter
F0Q13_RS12430	COG0725	ABC transporter, periplasmic molybdate-binding protein
F0Q13_RS12435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0Q13_RS12450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0Q13_RS12455	COG2181	nitrate reductase activity
F0Q13_RS12460	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
F0Q13_RS12465	COG1140	nitrate reductase beta subunit
F0Q13_RS12470	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F0Q13_RS12475	COG2223	nitrite transmembrane transporter activity
F0Q13_RS12485	COG0746	molybdenum cofactor guanylyltransferase activity
F0Q13_RS12490	COG0314	molybdopterin synthase activity
F0Q13_RS12500	COG0303	'Molybdopterin
F0Q13_RS12505	COG0521	Mo-molybdopterin cofactor biosynthetic process
F0Q13_RS12505	COG0315	cyclic pyranopterin monophosphate synthase activity
F0Q13_RS12510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0Q13_RS12540	COG2207	Transcriptional regulator
F0Q13_RS12635	COG1943	Transposase
F0Q13_RS12640	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS12645	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
F0Q13_RS12645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0Q13_RS12650	COG3433	isochorismatase activity
F0Q13_RS12650	COG1535	isochorismatase
F0Q13_RS12655	COG1535	isochorismatase
F0Q13_RS12655	COG3433	isochorismatase activity
F0Q13_RS12660	COG1021	2,3-dihydroxybenzoate-AMP ligase
F0Q13_RS12665	COG1169	isochorismate synthase
F0Q13_RS12675	COG2409	Drug exporters of the RND superfamily
F0Q13_RS12680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0Q13_RS12745	COG1914	H( )-stimulated, divalent metal cation uptake system
F0Q13_RS12760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0Q13_RS12765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0Q13_RS12780	COG4206	TonB-dependent receptor
F0Q13_RS12785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0Q13_RS12830	COG4772	TonB-dependent receptor
F0Q13_RS12850	COG2226	methyltransferase
F0Q13_RS12895	COG4964	Belongs to the GSP D family
F0Q13_RS12950	COG2814	Major facilitator Superfamily
F0Q13_RS12960	COG1228	amidohydrolase
F0Q13_RS12970	COG1335	isochorismatase
F0Q13_RS12985	COG3850	Histidine kinase
F0Q13_RS12990	COG2197	response regulator
F0Q13_RS13000	COG2814	Major facilitator Superfamily
F0Q13_RS13010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F0Q13_RS13020	COG0583	DNA-binding transcription factor activity
F0Q13_RS13040	COG3161	chorismate lyase activity
F0Q13_RS13085	COG0277	FAD linked oxidase domain protein
F0Q13_RS13090	COG1304	FMN binding
F0Q13_RS13095	COG2186	Transcriptional regulator
F0Q13_RS13110	COG1285	pathogenesis
F0Q13_RS13140	COG2814	Major facilitator Superfamily
F0Q13_RS13195	COG0587	DNA-directed DNA polymerase activity
F0Q13_RS13210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F0Q13_RS13215	COG0519	Catalyzes the synthesis of GMP from XMP
F0Q13_RS13215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0Q13_RS13230	COG1595	DNA-templated transcription, initiation
F0Q13_RS13240	COG1629	transport
F0Q13_RS13240	COG4206	TonB-dependent receptor
F0Q13_RS13265	COG1982	Orn Lys Arg decarboxylase major
F0Q13_RS13270	COG0531	amino acid
F0Q13_RS13285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0Q13_RS13295	COG0789	Transcriptional regulator
F0Q13_RS13360	COG3706	GGDEF domain
F0Q13_RS13385	COG5002	protein histidine kinase activity
F0Q13_RS13385	COG5001	Diguanylate cyclase
F0Q13_RS13385	COG3447	MASE1 domain protein
F0Q13_RS13390	COG2183	response to ionizing radiation
F0Q13_RS13420	COG3243	poly(R)-hydroxyalkanoic acid synthase
F0Q13_RS13435	COG1073	alpha beta
F0Q13_RS13435	COG2226	methyltransferase
F0Q13_RS13440	COG0534	Mate efflux family protein
F0Q13_RS13460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F0Q13_RS13470	COG0668	transmembrane transport
F0Q13_RS13475	COG1902	pentaerythritol trinitrate reductase activity
F0Q13_RS13485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F0Q13_RS13495	COG1733	regulation of RNA biosynthetic process
F0Q13_RS13500	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0Q13_RS13615	COG3702	type iv secretory pathway
F0Q13_RS13635	COG2948	multi-organism process
F0Q13_RS13645	COG3736	Type IV secretory pathway, component VirB8
F0Q13_RS13655	COG3505	Type IV secretory pathway VirD4
F0Q13_RS13665	COG2814	Major facilitator Superfamily
F0Q13_RS13670	COG0789	Transcriptional regulator
F0Q13_RS13675	COG1902	pentaerythritol trinitrate reductase activity
F0Q13_RS13675	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0Q13_RS13695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0Q13_RS13705	COG4774	siderophore transport
F0Q13_RS13715	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS13735	COG0577	efflux transmembrane transporter activity
F0Q13_RS13735	COG1136	(ABC) transporter
F0Q13_RS13770	COG1733	regulation of RNA biosynthetic process
F0Q13_RS13775	COG0604	alcohol dehydrogenase
F0Q13_RS13790	COG0210	DNA helicase
F0Q13_RS13800	COG0484	heat shock protein binding
F0Q13_RS13805	COG1196	nuclear chromosome segregation
F0Q13_RS13830	COG0583	DNA-binding transcription factor activity
F0Q13_RS13835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F0Q13_RS13845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0Q13_RS13860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F0Q13_RS13865	COG0077	Prephenate dehydratase
F0Q13_RS13865	COG1605	Chorismate mutase
F0Q13_RS13870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0Q13_RS13915	COG1228	amidohydrolase
F0Q13_RS13930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F0Q13_RS13985	COG2957	Belongs to the agmatine deiminase family
F0Q13_RS13990	COG0583	DNA-binding transcription factor activity
F0Q13_RS14070	COG4993	Dehydrogenase
F0Q13_RS14080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F0Q13_RS14090	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F0Q13_RS14100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0Q13_RS14105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0Q13_RS14120	COG0359	binds to the 23S rRNA
F0Q13_RS14125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0Q13_RS14130	COG0360	Binds together with S18 to 16S ribosomal RNA
F0Q13_RS14140	COG0316	Belongs to the HesB IscA family
F0Q13_RS14145	COG0017	Asparaginyl-tRNA synthetase
F0Q13_RS14165	COG0288	reversible hydration of carbon dioxide
F0Q13_RS14175	COG3844	kynureninase activity
F0Q13_RS14180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0Q13_RS14185	COG2925	Exonuclease
F0Q13_RS14195	COG0667	Aldo Keto reductase
F0Q13_RS14215	COG2902	Dehydrogenase
F0Q13_RS14225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS14230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS14240	COG1960	acyl-CoA dehydrogenase activity
F0Q13_RS14255	COG0646	methionine synthase
F0Q13_RS14255	COG1410	methionine synthase
F0Q13_RS14260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F0Q13_RS14260	COG2755	lipolytic protein G-D-S-L family
F0Q13_RS14270	COG2900	Belongs to the SlyX family
F0Q13_RS14285	COG0386	Belongs to the glutathione peroxidase family
F0Q13_RS14290	COG1725	Transcriptional regulator
F0Q13_RS14295	COG1131	(ABC) transporter
F0Q13_RS14320	COG0114	fumarate hydratase activity
F0Q13_RS14330	COG2850	peptidyl-arginine hydroxylation
F0Q13_RS14340	COG0567	Dehydrogenase, E1 component
F0Q13_RS14365	COG3540	Alkaline phosphatase
F0Q13_RS14375	COG0305	Participates in initiation and elongation during chromosome replication
F0Q13_RS14395	COG0625	glutathione transferase activity
F0Q13_RS14415	COG0084	hydrolase, TatD family'
F0Q13_RS14420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F0Q13_RS14455	COG0625	glutathione transferase activity
F0Q13_RS14475	COG1595	DNA-templated transcription, initiation
F0Q13_RS14480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0Q13_RS14500	COG0386	Belongs to the glutathione peroxidase family
F0Q13_RS14505	COG0339	signal peptide processing
F0Q13_RS14515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0Q13_RS14535	COG0705	Rhomboid family
F0Q13_RS14540	COG3104	oligopeptide transport
F0Q13_RS14550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F0Q13_RS14555	COG4290	ribonuclease
F0Q13_RS14570	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F0Q13_RS14570	COG0316	Belongs to the HesB IscA family
F0Q13_RS14575	COG2154	pterin-4-alpha-carbinolamine dehydratase
F0Q13_RS14585	COG0428	transporter
F0Q13_RS14595	COG1530	ribonuclease E activity
F0Q13_RS14610	COG0395	ABC-type sugar transport system, permease component
F0Q13_RS14640	COG0271	Belongs to the BolA IbaG family
F0Q13_RS14645	COG2350	Protein conserved in bacteria
F0Q13_RS14650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F0Q13_RS14655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F0Q13_RS14660	COG1187	pseudouridine synthase activity
F0Q13_RS14670	COG2814	Major facilitator Superfamily
F0Q13_RS14695	COG0436	Aminotransferase
F0Q13_RS14700	COG4133	protoheme IX ABC transporter activity
F0Q13_RS14720	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F0Q13_RS14735	COG3088	subunit of a heme lyase
F0Q13_RS14735	COG4235	cytochrome complex assembly
F0Q13_RS14745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F0Q13_RS14755	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F0Q13_RS14760	COG4988	ABC transporter
F0Q13_RS14770	COG1294	oxidase, subunit
F0Q13_RS14800	COG0726	polysaccharide deacetylase
F0Q13_RS14800	COG1649	PFAM Uncharacterised BCR, COG1649
F0Q13_RS14805	COG1215	transferase activity, transferring glycosyl groups
F0Q13_RS14815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F0Q13_RS14830	COG0165	Argininosuccinate lyase
F0Q13_RS14835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F0Q13_RS14845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0Q13_RS14850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0Q13_RS14855	COG0137	argininosuccinate synthase activity
F0Q13_RS14860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F0Q13_RS14875	COG2166	iron-sulfur cluster assembly
F0Q13_RS14895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0Q13_RS14915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0Q13_RS14920	COG0402	S-adenosylhomocysteine deaminase activity
F0Q13_RS14925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0Q13_RS14930	COG1509	lysine 2,3-aminomutase activity
F0Q13_RS14935	COG3300	MHYT domain
F0Q13_RS14935	COG5001	Diguanylate cyclase
F0Q13_RS14950	COG0483	inositol monophosphate 1-phosphatase activity
F0Q13_RS14955	COG0501	Belongs to the peptidase M48B family
F0Q13_RS14965	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS14985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F0Q13_RS14990	COG0860	N-Acetylmuramoyl-L-alanine amidase
F0Q13_RS14995	COG0802	atpase or kinase
F0Q13_RS15000	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F0Q13_RS15000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F0Q13_RS15005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0Q13_RS15010	COG1570	exodeoxyribonuclease VII activity
F0Q13_RS15020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F0Q13_RS15035	COG4771	TonB-dependent receptor
F0Q13_RS15040	COG1309	transcriptional regulator
F0Q13_RS15080	COG2169	Transcriptional regulator
F0Q13_RS15080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0Q13_RS15085	COG2130	NADP-dependent
F0Q13_RS15115	COG1960	acyl-CoA dehydrogenase activity
F0Q13_RS15125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0Q13_RS15155	COG1309	transcriptional regulator
F0Q13_RS15160	COG2076	Multidrug Resistance protein
F0Q13_RS15165	COG5487	UPF0391 membrane protein
F0Q13_RS15170	COG1280	lysine exporter protein (LysE YggA)
F0Q13_RS15175	COG0740	serine-type endopeptidase activity
F0Q13_RS15190	COG1794	racemase activity, acting on amino acids and derivatives
F0Q13_RS15245	COG0776	regulation of translation
F0Q13_RS15255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F0Q13_RS15260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0Q13_RS15265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0Q13_RS15270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F0Q13_RS15275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F0Q13_RS15310	COG1185	polyribonucleotide nucleotidyltransferase activity
F0Q13_RS15315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F0Q13_RS15325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0Q13_RS15330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0Q13_RS15335	COG0195	Participates in both transcription termination and antitermination
F0Q13_RS15340	COG0779	Required for maturation of 30S ribosomal subunits
F0Q13_RS15355	COG1007	ATP synthesis coupled electron transport
F0Q13_RS15370	COG0713	ATP synthesis coupled electron transport
F0Q13_RS15380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0Q13_RS15385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F0Q13_RS15400	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F0Q13_RS15405	COG0649	NAD binding
F0Q13_RS15410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0Q13_RS15415	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0Q13_RS15420	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0Q13_RS15435	COG0149	triose-phosphate isomerase activity
F0Q13_RS15445	COG3119	arylsulfatase activity
F0Q13_RS15450	COG0438	transferase activity, transferring glycosyl groups
F0Q13_RS15455	COG0726	polysaccharide deacetylase
F0Q13_RS15460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0Q13_RS15465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0Q13_RS15470	COG0159	tryptophan synthase activity
F0Q13_RS15480	COG0133	tryptophan synthase activity
F0Q13_RS15500	COG0135	phosphoribosylanthranilate isomerase activity
F0Q13_RS15505	COG0101	tRNA pseudouridine synthase activity
F0Q13_RS15520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0Q13_RS15525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0Q13_RS15530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0Q13_RS15535	COG2890	protein-(glutamine-N5) methyltransferase activity
F0Q13_RS15540	COG1999	signal sequence binding
F0Q13_RS15545	COG0688	phosphatidylethanolamine metabolic process
F0Q13_RS15560	COG0433	COG0433 Predicted ATPase
F0Q13_RS15565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0Q13_RS15575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0Q13_RS15580	COG0412	Dienelactone hydrolase
F0Q13_RS15595	COG0717	Belongs to the dCTP deaminase family
F0Q13_RS15600	COG0489	protein tyrosine kinase activity
F0Q13_RS15605	COG4771	TonB-dependent receptor
F0Q13_RS15610	COG4771	TonB-dependent receptor
F0Q13_RS15620	COG4771	TonB-dependent receptor
F0Q13_RS15625	COG3590	peptidase
F0Q13_RS15655	COG0697	spore germination
F0Q13_RS15665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0Q13_RS15670	COG2311	Membrane
F0Q13_RS15675	COG1047	Peptidyl-prolyl cis-trans
F0Q13_RS15680	COG0791	NLP P60 protein
F0Q13_RS15685	COG0791	NLP P60 protein
F0Q13_RS15690	COG1301	dicarboxylic acid transport
F0Q13_RS15710	COG1722	exodeoxyribonuclease VII activity
F0Q13_RS15715	COG0142	geranyltranstransferase activity
F0Q13_RS15725	COG0312	modulator of DNA gyrase
F0Q13_RS15730	COG3028	Belongs to the UPF0307 family
F0Q13_RS15735	COG0312	modulator of DNA gyrase
F0Q13_RS15745	COG1530	ribonuclease E activity
F0Q13_RS15755	COG2968	Membrane
F0Q13_RS15765	COG4771	TonB-dependent receptor
F0Q13_RS15780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F0Q13_RS15790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0Q13_RS15805	COG0495	leucyl-tRNA aminoacylation
F0Q13_RS15815	COG3118	belongs to the thioredoxin family
F0Q13_RS15825	COG2203	Gaf domain
F0Q13_RS15825	COG4251	negative regulation of phosphorylation
F0Q13_RS15825	COG3706	GGDEF domain
F0Q13_RS15825	COG5001	Diguanylate cyclase
F0Q13_RS15830	COG1943	Transposase
F0Q13_RS15850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F0Q13_RS15860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0Q13_RS15865	COG0346	lactoylglutathione lyase activity
F0Q13_RS15875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0Q13_RS15875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0Q13_RS15885	COG2878	Part of a membrane complex involved in electron transport
F0Q13_RS15890	COG0251	oxidation-reduction process
F0Q13_RS15895	COG0392	lysyltransferase activity
F0Q13_RS15895	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F0Q13_RS15925	COG2824	Alkylphosphonate utilization operon protein PhnA
F0Q13_RS15930	COG0443	Heat shock 70 kDa protein
F0Q13_RS15975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F0Q13_RS15980	COG3122	Protein conserved in bacteria
F0Q13_RS15985	COG1451	nucleotide metabolic process
F0Q13_RS15995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0Q13_RS16015	COG0183	Belongs to the thiolase family
F0Q13_RS16030	COG1960	acyl-CoA dehydrogenase activity
F0Q13_RS16040	COG1793	dna ligase
F0Q13_RS16045	COG1201	RNA secondary structure unwinding
F0Q13_RS16060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0Q13_RS16065	COG1278	Cold shock
F0Q13_RS16070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F0Q13_RS16080	COG1472	Belongs to the glycosyl hydrolase 3 family
F0Q13_RS16085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F0Q13_RS16090	COG2954	triphosphatase activity
F0Q13_RS16095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0Q13_RS16100	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS16105	COG1381	Involved in DNA repair and RecF pathway recombination
F0Q13_RS16110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0Q13_RS16125	COG0681	Belongs to the peptidase S26 family
F0Q13_RS16130	COG0481	GTPase activity
F0Q13_RS16135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0Q13_RS16155	COG1741	Belongs to the pirin family
F0Q13_RS16160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0Q13_RS16170	COG1741	Belongs to the pirin family
F0Q13_RS16175	COG1966	Carbon starvation protein
F0Q13_RS16180	COG2879	small protein
F0Q13_RS16195	COG2205	protein histidine kinase activity
F0Q13_RS16200	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS16235	COG2814	Major facilitator Superfamily
F0Q13_RS16240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0Q13_RS16240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0Q13_RS16250	COG1113	amino acid transport
F0Q13_RS16255	COG2207	Transcriptional regulator
F0Q13_RS16255	COG1917	Cupin 2, conserved barrel domain protein
F0Q13_RS16275	COG1376	ErfK ybiS ycfS ynhG family protein
F0Q13_RS16280	COG0739	heme binding
F0Q13_RS16290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0Q13_RS16300	COG0330	HflC and HflK could
F0Q13_RS16305	COG0330	HflC and HflK could
F0Q13_RS16310	COG0604	alcohol dehydrogenase
F0Q13_RS16325	COG0678	peroxiredoxin activity
F0Q13_RS16335	COG4953	penicillin-binding protein 1C
F0Q13_RS16340	COG2373	Large extracellular alpha-helical protein
F0Q13_RS16345	COG2079	MmgE PrpD family protein
F0Q13_RS16350	COG2828	Protein conserved in bacteria
F0Q13_RS16360	COG3609	addiction module antidote protein, CC2985 family
F0Q13_RS16400	COG0259	pyridoxamine-phosphate oxidase activity
F0Q13_RS16415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0Q13_RS16435	COG0477	Major facilitator Superfamily
F0Q13_RS16460	COG3038	cytochrome b561
F0Q13_RS16475	COG1760	l-serine dehydratase
F0Q13_RS16480	COG2267	carboxylic ester hydrolase activity
F0Q13_RS16485	COG0527	aspartate kinase activity
F0Q13_RS16485	COG0460	homoserine dehydrogenase
F0Q13_RS16490	COG0626	cystathionine gamma-synthase activity
F0Q13_RS16495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F0Q13_RS16500	COG0739	heme binding
F0Q13_RS16505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F0Q13_RS16510	COG1272	protein, Hemolysin III
F0Q13_RS16525	COG0463	Glycosyl transferase, family 2
F0Q13_RS16530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0Q13_RS16535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F0Q13_RS16545	COG4206	TonB-dependent receptor
F0Q13_RS16550	COG1309	transcriptional regulator
F0Q13_RS16560	COG1960	acyl-CoA dehydrogenase activity
F0Q13_RS16600	COG0583	DNA-binding transcription factor activity
F0Q13_RS16615	COG0509	glycine decarboxylation via glycine cleavage system
F0Q13_RS16620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0Q13_RS16630	COG0330	HflC and HflK could
F0Q13_RS16640	COG1742	UPF0060 membrane protein
F0Q13_RS16645	COG3956	TIGRFAM MazG family protein
F0Q13_RS16650	COG1218	3'(2'),5'-bisphosphate nucleotidase
F0Q13_RS16655	COG0494	nUDIX hydrolase
F0Q13_RS16665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F0Q13_RS16680	COG2198	Histidine kinase
F0Q13_RS16680	COG0784	Response regulator, receiver
F0Q13_RS16680	COG0643	Histidine kinase
F0Q13_RS16685	COG0840	transmembrane signaling receptor activity
F0Q13_RS16690	COG0835	chemotaxis
F0Q13_RS16705	COG0189	ligase activity
F0Q13_RS16725	COG1199	ATP-dependent helicase activity
F0Q13_RS16735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0Q13_RS16740	COG0463	Glycosyl transferase, family 2
F0Q13_RS16750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0Q13_RS16760	COG1643	Atp-dependent helicase
F0Q13_RS16765	COG0783	Belongs to the Dps family
F0Q13_RS16770	COG0514	ATP-dependent DNA helicase (RecQ)
F0Q13_RS16840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F0Q13_RS16845	COG0602	queuosine metabolic process
F0Q13_RS16855	COG2885	chlorophyll binding
F0Q13_RS16860	COG0823	Involved in the tonB-independent uptake of proteins
F0Q13_RS16875	COG0811	peptide transport
F0Q13_RS16880	COG0824	Thioesterase
F0Q13_RS16885	COG2255	four-way junction helicase activity
F0Q13_RS16895	COG0632	four-way junction helicase activity
F0Q13_RS16900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F0Q13_RS16905	COG0217	transcriptional regulatory protein
F0Q13_RS16925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0Q13_RS16955	COG0488	(ABC) transporter
F0Q13_RS16965	COG4651	solute:proton antiporter activity
F0Q13_RS16965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0Q13_RS16975	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS16980	COG2205	protein histidine kinase activity
F0Q13_RS16990	COG0542	response to heat
F0Q13_RS17015	COG0028	Belongs to the TPP enzyme family
F0Q13_RS17040	COG3387	PFAM Glycoside hydrolase 15-related
F0Q13_RS17045	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F0Q13_RS17050	COG3011	Protein conserved in bacteria
F0Q13_RS17065	COG0564	pseudouridine synthase activity
F0Q13_RS17070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0Q13_RS17080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0Q13_RS17080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0Q13_RS17090	COG0045	succinate-CoA ligase (ADP-forming) activity
F0Q13_RS17130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F0Q13_RS17140	COG2205	protein histidine kinase activity
F0Q13_RS17145	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS17160	COG0189	ligase activity
F0Q13_RS17185	COG3152	Membrane
F0Q13_RS17210	COG2022	thiamine diphosphate biosynthetic process
F0Q13_RS17215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F0Q13_RS17220	COG0471	metal ion transport
F0Q13_RS17220	COG3273	potassium ion transport
F0Q13_RS17240	COG1970	mechanosensitive ion channel activity
F0Q13_RS17250	COG1115	amino acid carrier protein
F0Q13_RS17260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0Q13_RS17265	COG1115	amino acid carrier protein
F0Q13_RS17270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0Q13_RS17275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS17280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS17305	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F0Q13_RS17315	COG3588	fructose-bisphosphate aldolase
F0Q13_RS17320	COG0469	pyruvate kinase activity
F0Q13_RS17330	COG0126	phosphoglycerate kinase activity
F0Q13_RS17345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0Q13_RS17350	COG3047	cAMP biosynthetic process
F0Q13_RS17390	COG3093	addiction module antidote protein HigA
F0Q13_RS17400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0Q13_RS17405	COG1301	dicarboxylic acid transport
F0Q13_RS17415	COG2304	oxidoreductase activity
F0Q13_RS17435	COG0714	Associated with various cellular activities
F0Q13_RS17465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F0Q13_RS17480	COG5295	Hep Hag repeat protein
F0Q13_RS17525	COG0254	rRNA binding
F0Q13_RS17540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0Q13_RS17550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0Q13_RS17555	COG1758	RNA polymerase activity
F0Q13_RS17570	COG0437	4 iron, 4 sulfur cluster binding
F0Q13_RS17575	COG2864	formate dehydrogenase
F0Q13_RS17585	COG1921	L-seryl-tRNASec selenium transferase activity
F0Q13_RS17590	COG3276	selenocysteine insertion sequence binding
F0Q13_RS17600	COG0709	Synthesizes selenophosphate from selenide and ATP
F0Q13_RS17615	COG1561	YicC-like family, N-terminal region
F0Q13_RS17620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F0Q13_RS17625	COG0346	lactoylglutathione lyase activity
F0Q13_RS17635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0Q13_RS17650	COG0006	proline dipeptidase activity
F0Q13_RS17655	COG0006	proline dipeptidase activity
F0Q13_RS17660	COG3079	Belongs to the UPF0149 family
F0Q13_RS17680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0Q13_RS17690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F0Q13_RS17700	COG2912	Transglutaminase-like superfamily
F0Q13_RS17705	COG1773	rubredoxin
F0Q13_RS17715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F0Q13_RS17730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0Q13_RS17735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0Q13_RS17750	COG4221	oxidoreductase activity
F0Q13_RS17775	COG0671	phosphoesterase, PA-phosphatase related
F0Q13_RS17785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0Q13_RS17790	COG0563	adenylate kinase activity
F0Q13_RS17815	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F0Q13_RS17825	COG0848	biopolymer transport protein
F0Q13_RS17835	COG2832	Protein of unknown function (DUF454)
F0Q13_RS17870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F0Q13_RS17895	COG0823	Involved in the tonB-independent uptake of proteins
F0Q13_RS17905	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F0Q13_RS17910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0Q13_RS17915	COG0405	Gamma-glutamyltransferase
F0Q13_RS17920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F0Q13_RS17940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0Q13_RS17945	COG2226	methyltransferase
F0Q13_RS17960	COG0473	3-isopropylmalate dehydrogenase activity
F0Q13_RS17975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS17980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS17995	COG1538	Outer membrane efflux protein
F0Q13_RS18000	COG0531	amino acid
F0Q13_RS18005	COG1519	Transferase
F0Q13_RS18010	COG1560	Kdo2-lipid A biosynthetic process
F0Q13_RS18060	COG1301	dicarboxylic acid transport
F0Q13_RS18070	COG4191	Histidine kinase
F0Q13_RS18085	COG0642	Histidine kinase
F0Q13_RS18100	COG2851	Citrate transporter
F0Q13_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS18125	COG1162	GTPase activity
F0Q13_RS18130	COG0436	Aminotransferase
F0Q13_RS18150	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F0Q13_RS18165	COG1228	amidohydrolase
F0Q13_RS18170	COG0804	urea catabolic process
F0Q13_RS18180	COG1307	EDD domain protein, DegV family
F0Q13_RS18220	COG5001	Diguanylate cyclase
F0Q13_RS18220	COG4251	negative regulation of phosphorylation
F0Q13_RS18220	COG3706	GGDEF domain
F0Q13_RS18220	COG2203	Gaf domain
F0Q13_RS18225	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F0Q13_RS18235	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F0Q13_RS18245	COG4206	TonB-dependent receptor
F0Q13_RS18255	COG1902	pentaerythritol trinitrate reductase activity
F0Q13_RS18280	COG0583	DNA-binding transcription factor activity
F0Q13_RS18285	COG1064	alcohol dehydrogenase
F0Q13_RS18295	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F0Q13_RS18315	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F0Q13_RS18320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F0Q13_RS18330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0Q13_RS18335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0Q13_RS18350	COG1522	sequence-specific DNA binding
F0Q13_RS18360	COG4773	Receptor
F0Q13_RS18370	COG4206	TonB-dependent receptor
F0Q13_RS18395	COG0617	tRNA 3'-terminal CCA addition
F0Q13_RS18425	COG3468	outer membrane autotransporter barrel domain protein
F0Q13_RS18435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0Q13_RS18440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0Q13_RS18445	COG1609	Transcriptional regulator
F0Q13_RS18455	COG0837	glucose binding
F0Q13_RS18465	COG3525	Glycosyl hydrolase, family 20, catalytic domain
F0Q13_RS18485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0Q13_RS18495	COG4191	Histidine kinase
F0Q13_RS18500	COG0784	Response regulator, receiver
F0Q13_RS18505	COG4251	negative regulation of phosphorylation
F0Q13_RS18510	COG2823	Periplasmic or secreted lipoprotein
F0Q13_RS18515	COG0673	inositol 2-dehydrogenase activity
F0Q13_RS18525	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F0Q13_RS18545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F0Q13_RS18550	COG0321	lipoyl(octanoyl) transferase activity
F0Q13_RS18555	COG2921	Belongs to the UPF0250 family
F0Q13_RS18565	COG1686	Belongs to the peptidase S11 family
F0Q13_RS18570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0Q13_RS18575	COG2951	lytic endotransglycosylase activity
F0Q13_RS18580	COG0772	Belongs to the SEDS family
F0Q13_RS18585	COG0772	Belongs to the SEDS family
F0Q13_RS18590	COG0768	penicillin binding
F0Q13_RS18600	COG1792	Involved in formation and maintenance of cell shape
F0Q13_RS18605	COG1077	Cell shape determining protein MreB Mrl
F0Q13_RS18610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0Q13_RS18625	COG0308	aminopeptidase N
F0Q13_RS18630	COG2226	methyltransferase
F0Q13_RS18660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS18680	COG0673	inositol 2-dehydrogenase activity
F0Q13_RS18690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F0Q13_RS18710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F0Q13_RS18720	COG2832	Protein of unknown function (DUF454)
F0Q13_RS18735	COG1505	serine-type exopeptidase activity
F0Q13_RS18770	COG0697	spore germination
F0Q13_RS18775	COG1666	GTP binding
F0Q13_RS18805	COG0339	signal peptide processing
F0Q13_RS18815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0Q13_RS18835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0Q13_RS18845	COG1136	(ABC) transporter
F0Q13_RS18850	COG0577	efflux transmembrane transporter activity
F0Q13_RS18850	COG1136	(ABC) transporter
F0Q13_RS18855	COG0577	efflux transmembrane transporter activity
F0Q13_RS18865	COG2204	response regulator
F0Q13_RS18870	COG4191	Histidine kinase
F0Q13_RS18880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F0Q13_RS18890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0Q13_RS18895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F0Q13_RS18900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F0Q13_RS18905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0Q13_RS18910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0Q13_RS18915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0Q13_RS18925	COG0356	it plays a direct role in the translocation of protons across the membrane
F0Q13_RS18940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0Q13_RS18945	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0Q13_RS18965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0Q13_RS18990	COG0181	hydroxymethylbilane synthase activity
F0Q13_RS19000	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS19000	COG2972	Histidine kinase
F0Q13_RS19015	COG4771	TonB-dependent receptor
F0Q13_RS19030	COG0840	transmembrane signaling receptor activity
F0Q13_RS19060	COG0477	Major facilitator Superfamily
F0Q13_RS19085	COG0583	DNA-binding transcription factor activity
F0Q13_RS19090	COG0477	Major facilitator Superfamily
F0Q13_RS19110	COG4206	TonB-dependent receptor
F0Q13_RS19135	COG0625	glutathione transferase activity
F0Q13_RS19150	COG2259	Doxx family
F0Q13_RS19205	COG3550	peptidyl-serine autophosphorylation
F0Q13_RS19210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0Q13_RS19215	COG1490	D-aminoacyl-tRNA deacylase activity
F0Q13_RS19260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0Q13_RS19260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0Q13_RS19265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0Q13_RS19270	COG0242	peptide deformylase activity
F0Q13_RS19280	COG0758	DNA mediated transformation
F0Q13_RS19285	COG2922	Belongs to the Smg family
F0Q13_RS19295	COG1714	RDD family
F0Q13_RS19300	COG1754	DNA topoisomerase type I activity
F0Q13_RS19300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0Q13_RS19305	COG0009	L-threonylcarbamoyladenylate synthase
F0Q13_RS19320	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS19330	COG0616	signal peptide processing
F0Q13_RS19335	COG0534	Mate efflux family protein
F0Q13_RS19350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F0Q13_RS19355	COG0625	glutathione transferase activity
F0Q13_RS19365	COG1252	NADH dehydrogenase
F0Q13_RS19380	COG2860	membrane
F0Q13_RS19390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS19395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS19405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0Q13_RS19425	COG1846	Transcriptional regulator
F0Q13_RS19435	COG0625	glutathione transferase activity
F0Q13_RS19445	COG0459	protein refolding
F0Q13_RS19450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0Q13_RS19455	COG2356	endonuclease I
F0Q13_RS19460	COG1324	tolerance protein
F0Q13_RS19470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0Q13_RS19480	COG0840	transmembrane signaling receptor activity
F0Q13_RS19500	COG4585	Histidine kinase
F0Q13_RS19520	COG0583	DNA-binding transcription factor activity
F0Q13_RS19530	COG1785	Belongs to the alkaline phosphatase family
F0Q13_RS19535	COG1686	Belongs to the peptidase S11 family
F0Q13_RS19545	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0Q13_RS19565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F0Q13_RS19575	COG0511	ligase activity, forming carbon-carbon bonds
F0Q13_RS19580	COG0439	Biotin carboxylase
F0Q13_RS19595	COG2264	protein methyltransferase activity
F0Q13_RS19605	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F0Q13_RS19610	COG4589	Belongs to the CDS family
F0Q13_RS19615	COG0204	Acyl-transferase
F0Q13_RS19625	COG2453	phosphatase
F0Q13_RS19625	COG0671	phosphoesterase, PA-phosphatase related
F0Q13_RS19630	COG2267	carboxylic ester hydrolase activity
F0Q13_RS19635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F0Q13_RS19640	COG0138	bifunctional purine biosynthesis protein purh
F0Q13_RS19655	COG0151	Belongs to the GarS family
F0Q13_RS19660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0Q13_RS19665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0Q13_RS19670	COG2201	protein-glutamate methylesterase activity
F0Q13_RS19675	COG2177	Part of the ABC transporter FtsEX involved in
F0Q13_RS19680	COG2884	Cell division ATP-binding protein ftsE
F0Q13_RS19690	COG3118	belongs to the thioredoxin family
F0Q13_RS19695	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F0Q13_RS19700	COG3706	GGDEF domain
F0Q13_RS19710	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
F0Q13_RS19755	COG1652	LysM domain
F0Q13_RS19760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0Q13_RS19760	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0Q13_RS19765	COG1473	amidohydrolase
F0Q13_RS19770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0Q13_RS19775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0Q13_RS19790	COG1289	transmembrane transporter activity
F0Q13_RS19795	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS19800	COG2814	Major facilitator Superfamily
F0Q13_RS19830	COG0316	Belongs to the HesB IscA family
F0Q13_RS19870	COG1051	belongs to the nudix hydrolase family
F0Q13_RS19885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0Q13_RS19890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0Q13_RS19895	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
F0Q13_RS19905	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F0Q13_RS19910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0Q13_RS19915	COG0730	response to heat
F0Q13_RS19925	COG0134	indole-3-glycerol-phosphate synthase activity
F0Q13_RS19930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0Q13_RS19960	COG1597	lipid kinase activity
F0Q13_RS19975	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F0Q13_RS19980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0Q13_RS19990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0Q13_RS19990	COG2111	Na H antiporter
F0Q13_RS19995	COG1006	Multisubunit Na H antiporter MnhC subunit
F0Q13_RS20000	COG0651	ATP synthesis coupled electron transport
F0Q13_RS20005	COG1863	multisubunit Na H antiporter MnhE subunit
F0Q13_RS20010	COG2212	antiporter activity
F0Q13_RS20015	COG1320	monovalent cation:proton antiporter activity
F0Q13_RS20020	COG0530	calcium, potassium:sodium antiporter activity
F0Q13_RS20035	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
F0Q13_RS20050	COG4804	nuclease activity
F0Q13_RS20065	COG3104	oligopeptide transport
F0Q13_RS20070	COG3483	tryptophan 2,3-dioxygenase activity
F0Q13_RS20100	COG2378	regulation of single-species biofilm formation
F0Q13_RS20115	COG2354	Protein conserved in bacteria
F0Q13_RS20120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F0Q13_RS20125	COG1368	sulfuric ester hydrolase activity
F0Q13_RS20130	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F0Q13_RS20130	COG3264	Mechanosensitive ion channel
F0Q13_RS20145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0Q13_RS20165	COG0745	RESPONSE REGULATOR receiver
F0Q13_RS20180	COG1166	arginine decarboxylase activity
F0Q13_RS20185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F0Q13_RS20210	COG2960	long-chain fatty acid transporting porin activity
F0Q13_RS20245	COG0577	efflux transmembrane transporter activity
F0Q13_RS20250	COG1136	(ABC) transporter
F0Q13_RS20250	COG0577	efflux transmembrane transporter activity
F0Q13_RS20280	COG0606	chelatase, subunit chli
F0Q13_RS20295	COG0561	phosphatase activity
F0Q13_RS20300	COG3932	Exopolysaccharide synthesis, ExoD
F0Q13_RS20325	COG1999	signal sequence binding
F0Q13_RS20330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F0Q13_RS20335	COG1845	cytochrome c oxidase, subunit III
F0Q13_RS20345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F0Q13_RS20350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0Q13_RS20365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0Q13_RS20370	COG1104	cysteine desulfurase activity
F0Q13_RS20390	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
F0Q13_RS20415	COG2031	fatty acid transporter
F0Q13_RS20430	COG2207	Transcriptional regulator
F0Q13_RS20430	COG4753	response regulator
F0Q13_RS20460	COG0673	inositol 2-dehydrogenase activity
F0Q13_RS20470	COG1501	Belongs to the glycosyl hydrolase 31 family
F0Q13_RS20475	COG2222	sugar isomerase
F0Q13_RS20480	COG1940	carbohydrate kinase activity
F0Q13_RS20490	COG1349	DNA-binding transcription factor activity
F0Q13_RS20495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0Q13_RS20500	COG2814	Major facilitator Superfamily
F0Q13_RS20515	COG1040	competence protein
F0Q13_RS20535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0Q13_RS20540	COG0156	8-amino-7-oxononanoate synthase activity
F0Q13_RS20545	COG2267	carboxylic ester hydrolase activity
F0Q13_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS20580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F0Q13_RS20605	COG0714	Associated with various cellular activities
F0Q13_RS20615	COG0754	glutathionylspermidine amidase activity
F0Q13_RS20625	COG0129	dihydroxy-acid dehydratase activity
F0Q13_RS20630	COG2311	Membrane
F0Q13_RS20635	COG1199	ATP-dependent helicase activity
F0Q13_RS20645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0Q13_RS20665	COG3781	membrane
F0Q13_RS20685	COG3291	Pkd domain containing protein
F0Q13_RS20700	COG0625	glutathione transferase activity
F0Q13_RS20720	COG2207	Transcriptional regulator
F0Q13_RS20735	COG4555	ABC transporter
F0Q13_RS20870	COG4771	TonB-dependent receptor
F0Q13_RS20875	COG4221	oxidoreductase activity
F0Q13_RS20880	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS20885	COG0583	DNA-binding transcription factor activity
F0Q13_RS20925	COG0633	Ferredoxin
F0Q13_RS20925	COG0543	2 iron, 2 sulfur cluster binding
F0Q13_RS20930	COG1131	(ABC) transporter
F0Q13_RS20935	COG0842	Transport permease protein
F0Q13_RS20945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F0Q13_RS20955	COG0084	hydrolase, TatD family'
F0Q13_RS20960	COG1643	Atp-dependent helicase
F0Q13_RS20970	COG1187	pseudouridine synthase activity
F0Q13_RS20990	COG0667	Aldo Keto reductase
F0Q13_RS21005	COG1690	Belongs to the RtcB family
F0Q13_RS21025	COG0583	DNA-binding transcription factor activity
F0Q13_RS21030	COG2814	Major facilitator Superfamily
F0Q13_RS21035	COG0656	L-ascorbic acid biosynthetic process
F0Q13_RS21040	COG2267	carboxylic ester hydrolase activity
F0Q13_RS21045	COG0393	Putative heavy-metal-binding
F0Q13_RS21050	COG1042	CoA-binding domain protein
F0Q13_RS21050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0Q13_RS21050	COG0045	succinate-CoA ligase (ADP-forming) activity
F0Q13_RS21055	COG2239	Acts as a magnesium transporter
F0Q13_RS21070	COG3100	YcgL domain-containing protein
F0Q13_RS21080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0Q13_RS21085	COG1028	Short-chain dehydrogenase reductase Sdr
F0Q13_RS21125	COG2986	histidine ammonia-lyase
F0Q13_RS21135	COG0463	Glycosyl transferase, family 2
F0Q13_RS21140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0Q13_RS21150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0Q13_RS21155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0Q13_RS21170	COG1294	oxidase, subunit
F0Q13_RS21175	COG1271	oxidase subunit
F0Q13_RS21220	COG0494	nUDIX hydrolase
F0Q13_RS21240	COG0408	coproporphyrinogen oxidase activity
F0Q13_RS21250	COG2323	membrane
F0Q13_RS21265	COG0589	response to stress
F0Q13_RS21285	COG0210	DNA helicase
F0Q13_RS21295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0Q13_RS21300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0Q13_RS21305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0Q13_RS21320	COG0251	oxidation-reduction process
F0Q13_RS21360	COG0463	Glycosyl transferase, family 2
F0Q13_RS21375	COG1475	DNA binding
F0Q13_RS21380	COG1192	Involved in chromosome partitioning
F0Q13_RS21385	COG0357	Ribosomal RNA small subunit methyltransferase G
F0Q13_RS21390	COG2091	lysine biosynthetic process via aminoadipic acid
F0Q13_RS21450	COG1971	Probably functions as a manganese efflux pump
F0Q13_RS21455	COG0784	Response regulator, receiver
F0Q13_RS21455	COG2205	protein histidine kinase activity
F0Q13_RS21465	COG2911	Protein conserved in bacteria
F0Q13_RS21470	COG0729	surface antigen
F0Q13_RS21480	COG0752	glycyl-tRNA synthetase alpha subunit
F0Q13_RS21490	COG0519	Catalyzes the synthesis of GMP from XMP
F0Q13_RS21490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0Q13_RS21500	COG0805	protein transport
F0Q13_RS21510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0Q13_RS21520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F0Q13_RS21530	COG0840	transmembrane signaling receptor activity
F0Q13_RS21585	COG3135	benzoate transporter
F0Q13_RS21600	COG2951	lytic endotransglycosylase activity
F0Q13_RS21605	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F0Q13_RS21610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F0Q13_RS21615	COG3706	GGDEF domain
F0Q13_RS21645	COG0302	gtp cyclohydrolase
F0Q13_RS21660	COG1566	PFAM secretion protein HlyD family protein
F0Q13_RS21670	COG1289	transmembrane transporter activity
F0Q13_RS21680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0Q13_RS21685	COG1074	ATP-dependent DNA helicase activity
F0Q13_RS21690	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F0Q13_RS21695	COG1127	ABC transporter
F0Q13_RS21700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0Q13_RS21705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0Q13_RS21720	COG2853	Lipoprotein
F0Q13_RS21725	COG0386	Belongs to the glutathione peroxidase family
F0Q13_RS21735	COG1322	Protein conserved in bacteria
F0Q13_RS21745	COG0604	alcohol dehydrogenase
F0Q13_RS21750	COG0583	DNA-binding transcription factor activity
F0Q13_RS21770	COG0531	amino acid
F0Q13_RS21780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0Q13_RS21785	COG0861	Integral membrane protein TerC family
F0Q13_RS21795	COG0584	glycerophosphoryl diester phosphodiesterase
F0Q13_RS21810	COG0706	membrane insertase activity
F0Q13_RS21815	COG0594	ribonuclease P activity
F0Q13_RS21820	COG0230	Belongs to the bacterial ribosomal protein bL34 family