locus-tag	class	description
C9J74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C9J74_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C9J74_RS00020	COG0187	DNA topoisomerase II activity
C9J74_RS00025	COG1266	CAAX protease self-immunity
C9J74_RS00030	COG0501	Belongs to the peptidase M48B family
C9J74_RS00105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C9J74_RS00120	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS00160	COG3422	double-strand break repair
C9J74_RS00170	COG0659	secondary active sulfate transmembrane transporter activity
C9J74_RS00185	COG0798	PFAM Bile acid sodium symporter
C9J74_RS00200	COG0431	NADPH-dependent FMN reductase
C9J74_RS00225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C9J74_RS00240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C9J74_RS00240	COG3453	Protein conserved in bacteria
C9J74_RS00260	COG0640	Transcriptional regulator
C9J74_RS00310	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C9J74_RS00320	COG4772	TonB-dependent receptor
C9J74_RS00355	COG0800	Aldolase
C9J74_RS00370	COG3186	Phenylalanine-4-hydroxylase
C9J74_RS00375	COG1522	sequence-specific DNA binding
C9J74_RS00385	COG1752	Esterase of the alpha-beta hydrolase superfamily
C9J74_RS00415	COG1122	ATPase activity
C9J74_RS00435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C9J74_RS00440	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C9J74_RS00445	COG1435	thymidine kinase activity
C9J74_RS00450	COG0210	DNA helicase
C9J74_RS00460	COG3132	Protein of unknown function, DUF480
C9J74_RS00465	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C9J74_RS00470	COG0284	orotidine-5'-phosphate decarboxylase activity
C9J74_RS00480	COG2937	Belongs to the GPAT DAPAT family
C9J74_RS00490	COG0037	tRNA processing
C9J74_RS00495	COG2974	May be involved in recombination
C9J74_RS00505	COG1803	Methylglyoxal synthase
C9J74_RS00510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9J74_RS00510	COG2205	protein histidine kinase activity
C9J74_RS00515	COG0493	'glutamate synthase
C9J74_RS00520	COG0067	glutamate synthase
C9J74_RS00520	COG0070	glutamate synthase
C9J74_RS00520	COG0069	glutamate synthase activity
C9J74_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS00545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C9J74_RS00570	COG1111	helicase
C9J74_RS00570	COG1205	dead DEAH box helicase
C9J74_RS00605	COG0714	Associated with various cellular activities
C9J74_RS00625	COG0312	modulator of DNA gyrase
C9J74_RS00645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C9J74_RS00665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C9J74_RS00670	COG2050	protein possibly involved in aromatic compounds catabolism
C9J74_RS00690	COG1881	PFAM PEBP family protein
C9J74_RS00700	COG1968	undecaprenyl-diphosphatase activity
C9J74_RS00705	COG0174	glutamine synthetase
C9J74_RS00710	COG0347	Belongs to the P(II) protein family
C9J74_RS00715	COG0004	ammonium transporteR
C9J74_RS00725	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C9J74_RS00735	COG3852	Histidine kinase
C9J74_RS00740	COG2204	response regulator
C9J74_RS00745	COG2032	superoxide dismutase activity
C9J74_RS00750	COG2032	superoxide dismutase activity
C9J74_RS00760	COG0183	Belongs to the thiolase family
C9J74_RS00795	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C9J74_RS00800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C9J74_RS00820	COG0798	PFAM Bile acid sodium symporter
C9J74_RS00835	COG0431	NADPH-dependent FMN reductase
C9J74_RS00980	COG2837	iron assimilation
C9J74_RS01025	COG2197	response regulator
C9J74_RS01030	COG2205	protein histidine kinase activity
C9J74_RS01030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9J74_RS01035	COG3474	cytochrome
C9J74_RS01045	COG1960	acyl-CoA dehydrogenase activity
C9J74_RS01050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C9J74_RS01060	COG0612	Peptidase, M16
C9J74_RS01070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C9J74_RS01075	COG0596	Alpha beta hydrolase
C9J74_RS01085	COG0318	PFAM AMP-dependent synthetase and ligase
C9J74_RS01090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C9J74_RS01100	COG1181	Belongs to the D-alanine--D-alanine ligase family
C9J74_RS01110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C9J74_RS01140	COG0339	signal peptide processing
C9J74_RS01155	COG0681	Belongs to the peptidase S26 family
C9J74_RS01160	COG2814	Major facilitator Superfamily
C9J74_RS01165	COG0583	DNA-binding transcription factor activity
C9J74_RS01175	COG0583	DNA-binding transcription factor activity
C9J74_RS01180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C9J74_RS01185	COG2224	Isocitrate lyase
C9J74_RS01190	COG3706	GGDEF domain
C9J74_RS01215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C9J74_RS01220	COG1960	acyl-CoA dehydrogenase activity
C9J74_RS01240	COG0697	spore germination
C9J74_RS01250	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C9J74_RS01265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C9J74_RS01270	COG1280	lysine exporter protein (LysE YggA)
C9J74_RS01275	COG1607	acyl-coa hydrolase
C9J74_RS01285	COG1902	pentaerythritol trinitrate reductase activity
C9J74_RS01300	COG1335	isochorismatase
C9J74_RS01305	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C9J74_RS01315	COG1056	cytidyltransferase-related domain
C9J74_RS01315	COG1051	belongs to the nudix hydrolase family
C9J74_RS01320	COG1752	Esterase of the alpha-beta hydrolase superfamily
C9J74_RS01335	COG3800	Transcriptional regulator
C9J74_RS01335	COG1396	sequence-specific DNA binding
C9J74_RS01345	COG1960	acyl-CoA dehydrogenase activity
C9J74_RS01350	COG1024	Enoyl-CoA hydratase
C9J74_RS01355	COG1024	Enoyl-CoA hydratase
C9J74_RS01365	COG1764	response to oxidative stress
C9J74_RS01385	COG3657	addiction module killer protein
C9J74_RS01410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C9J74_RS01440	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C9J74_RS01440	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C9J74_RS01445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C9J74_RS01470	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9J74_RS01505	COG3237	CsbD-like
C9J74_RS01625	COG4373	Mu-like prophage FluMu protein gp28
C9J74_RS01750	COG2974	May be involved in recombination
C9J74_RS01780	COG0180	Tryptophanyl-tRNA synthetase
C9J74_RS01805	COG0477	Major facilitator Superfamily
C9J74_RS01810	COG0697	spore germination
C9J74_RS01825	COG0577	efflux transmembrane transporter activity
C9J74_RS01825	COG1136	(ABC) transporter
C9J74_RS01835	COG1136	(ABC) transporter
C9J74_RS01840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS01855	COG4585	Histidine kinase
C9J74_RS01860	COG2197	response regulator
C9J74_RS01880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C9J74_RS01890	COG0628	permease
C9J74_RS01910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C9J74_RS01925	COG5507	3-demethylubiquinone-9 3-methyltransferase
C9J74_RS01955	COG2814	Major facilitator Superfamily
C9J74_RS01960	COG0583	DNA-binding transcription factor activity
C9J74_RS01965	COG4807	Protein conserved in bacteria
C9J74_RS01970	COG4221	oxidoreductase activity
C9J74_RS01980	COG0018	arginyl-trna synthetase
C9J74_RS01985	COG2003	Belongs to the UPF0758 family
C9J74_RS01990	COG2197	response regulator
C9J74_RS01995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C9J74_RS02015	COG2205	protein histidine kinase activity
C9J74_RS02025	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C9J74_RS02030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C9J74_RS02045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C9J74_RS02050	COG0708	Exodeoxyribonuclease III
C9J74_RS02055	COG2223	nitrite transmembrane transporter activity
C9J74_RS02070	COG0739	heme binding
C9J74_RS02075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C9J74_RS02135	COG2234	aminopeptidase activity
C9J74_RS02145	COG4942	peptidase
C9J74_RS02150	COG0793	Belongs to the peptidase S41A family
C9J74_RS02160	COG2067	long-chain fatty acid transport protein
C9J74_RS02185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C9J74_RS02230	COG0109	protoheme IX farnesyltransferase activity
C9J74_RS02245	COG0358	DNA primase activity
C9J74_RS02250	COG1295	ribonuclease BN
C9J74_RS02265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C9J74_RS02275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C9J74_RS02280	COG0668	transmembrane transport
C9J74_RS02295	COG2133	pyrroloquinoline quinone binding
C9J74_RS02300	COG4682	membrane
C9J74_RS02310	COG0531	amino acid
C9J74_RS02320	COG1737	Transcriptional regulator
C9J74_RS02325	COG4948	Mandelate Racemase Muconate Lactonizing
C9J74_RS02375	COG5383	Protein conserved in bacteria
C9J74_RS02385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C9J74_RS02390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C9J74_RS02420	COG0778	Nitroreductase
C9J74_RS02425	COG2353	YceI-like domain
C9J74_RS02440	COG2375	cellular response to nickel ion
C9J74_RS02560	COG2267	carboxylic ester hydrolase activity
C9J74_RS02625	COG0488	(ABC) transporter
C9J74_RS02630	COG0583	DNA-binding transcription factor activity
C9J74_RS02640	COG2814	Major facilitator Superfamily
C9J74_RS02645	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C9J74_RS02650	COG1113	amino acid transport
C9J74_RS02655	COG0741	lytic transglycosylase activity
C9J74_RS02680	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C9J74_RS02695	COG4941	Belongs to the sigma-70 factor family
C9J74_RS02730	COG3275	phosphorelay sensor kinase activity
C9J74_RS02735	COG3279	Response regulator of the LytR AlgR family
C9J74_RS02755	COG1309	transcriptional regulator
C9J74_RS02770	COG3590	peptidase
C9J74_RS02775	COG5001	Diguanylate cyclase
C9J74_RS02780	COG0583	DNA-binding transcription factor activity
C9J74_RS02790	COG3384	dioxygenase
C9J74_RS02795	COG0025	NhaP-type Na H and K H
C9J74_RS02820	COG1360	Flagellar Motor Protein
C9J74_RS02850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C9J74_RS02870	COG2205	protein histidine kinase activity
C9J74_RS02870	COG0784	Response regulator, receiver
C9J74_RS02885	COG2813	Specifically methylates the guanine in position
C9J74_RS02890	COG1187	pseudouridine synthase activity
C9J74_RS02895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C9J74_RS02905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C9J74_RS02910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C9J74_RS02925	COG0583	DNA-binding transcription factor activity
C9J74_RS02930	COG2226	methyltransferase
C9J74_RS02955	COG1956	GAF domain-containing protein
C9J74_RS02960	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C9J74_RS02965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C9J74_RS02970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C9J74_RS02975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C9J74_RS02975	COG0785	Cytochrome C biogenesis protein
C9J74_RS02980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C9J74_RS02985	COG0745	RESPONSE REGULATOR receiver
C9J74_RS02990	COG5002	protein histidine kinase activity
C9J74_RS02995	COG2205	protein histidine kinase activity
C9J74_RS03000	COG0745	RESPONSE REGULATOR receiver
C9J74_RS03005	COG0367	asparagine synthase
C9J74_RS03015	COG0720	synthase
C9J74_RS03030	COG0513	Belongs to the DEAD box helicase family
C9J74_RS03045	COG0625	glutathione transferase activity
C9J74_RS03050	COG1573	uracil-dna glycosylase
C9J74_RS03085	COG0626	cystathionine gamma-synthase activity
C9J74_RS03100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C9J74_RS03160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C9J74_RS03185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C9J74_RS03190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C9J74_RS03200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C9J74_RS03210	COG1216	Glycosyl transferase, family 2
C9J74_RS03225	COG1127	ABC transporter
C9J74_RS03230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C9J74_RS03245	COG0442	prolyl-tRNA aminoacylation
C9J74_RS03260	COG1183	phosphatidylcholine synthase activity
C9J74_RS03270	COG0456	acetyltransferase
C9J74_RS03280	COG0525	valine-tRNA ligase activity
C9J74_RS03290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C9J74_RS03300	COG0795	lipopolysaccharide-transporting ATPase activity
C9J74_RS03310	COG4974	Belongs to the 'phage' integrase family
C9J74_RS03315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C9J74_RS03330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C9J74_RS03330	COG0047	phosphoribosylformylglycinamidine synthase activity
C9J74_RS03335	COG5295	Hep Hag repeat protein
C9J74_RS03340	COG1404	Belongs to the peptidase S8 family
C9J74_RS03345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C9J74_RS03350	COG1459	type II secretion system
C9J74_RS03355	COG2165	general secretion pathway protein
C9J74_RS03360	COG4970	Tfp pilus assembly protein FimT
C9J74_RS03365	COG2165	general secretion pathway protein
C9J74_RS03370	COG4795	General secretion pathway protein
C9J74_RS03375	COG3156	type II secretion system protein K
C9J74_RS03380	COG3166	PFAM Fimbrial assembly family protein
C9J74_RS03395	COG1450	Type ii and iii secretion system protein
C9J74_RS03420	COG3539	Fimbrial protein
C9J74_RS03440	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C9J74_RS03450	COG1215	transferase activity, transferring glycosyl groups
C9J74_RS03465	COG2252	PERMEase
C9J74_RS03470	COG0488	(ABC) transporter
C9J74_RS03480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C9J74_RS03495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C9J74_RS03500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C9J74_RS03500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C9J74_RS03535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C9J74_RS03540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C9J74_RS03565	COG3188	usher protein
C9J74_RS03585	COG0488	(ABC) transporter
C9J74_RS03590	COG0277	FAD linked oxidase domain protein
C9J74_RS03595	COG1988	membrane-bound metal-dependent
C9J74_RS03630	COG2001	Belongs to the MraZ family
C9J74_RS03635	COG0275	rRNA processing
C9J74_RS03640	COG3116	cell division
C9J74_RS03650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C9J74_RS03655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C9J74_RS03670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C9J74_RS03675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C9J74_RS03680	COG1181	Belongs to the D-alanine--D-alanine ligase family
C9J74_RS03685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C9J74_RS03695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C9J74_RS03700	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C9J74_RS03710	COG0739	heme binding
C9J74_RS03715	COG0653	protein targeting
C9J74_RS03720	COG0494	nUDIX hydrolase
C9J74_RS03730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C9J74_RS03740	COG3275	phosphorelay sensor kinase activity
C9J74_RS03745	COG3279	Response regulator of the LytR AlgR family
C9J74_RS03765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C9J74_RS03770	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C9J74_RS03780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C9J74_RS03785	COG1607	acyl-coa hydrolase
C9J74_RS03790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C9J74_RS03820	COG4106	trans-aconitate 2-methyltransferase activity
C9J74_RS03825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C9J74_RS03835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C9J74_RS03840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C9J74_RS03845	COG0667	Aldo Keto reductase
C9J74_RS03855	COG4771	TonB-dependent receptor
C9J74_RS03870	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C9J74_RS03875	COG4181	ATPase activity
C9J74_RS03890	COG0642	Histidine kinase
C9J74_RS03905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C9J74_RS03910	COG0861	Integral membrane protein TerC family
C9J74_RS03915	COG2814	Major facilitator Superfamily
C9J74_RS03925	COG1704	LemA family
C9J74_RS03940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C9J74_RS03945	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C9J74_RS03960	COG3738	Protein conserved in bacteria
C9J74_RS03965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C9J74_RS03970	COG2967	ApaG domain
C9J74_RS03975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C9J74_RS03980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C9J74_RS03985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C9J74_RS03990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C9J74_RS04000	COG2096	Adenosyltransferase
C9J74_RS04010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9J74_RS04015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9J74_RS04020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C9J74_RS04025	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C9J74_RS04045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C9J74_RS04055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C9J74_RS04065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C9J74_RS04070	COG0583	DNA-binding transcription factor activity
C9J74_RS04075	COG3634	alkyl hydroperoxide reductase activity
C9J74_RS04130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C9J74_RS04155	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C9J74_RS04170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C9J74_RS04175	COG1404	Belongs to the peptidase S8 family
C9J74_RS04195	COG1295	ribonuclease BN
C9J74_RS04200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C9J74_RS04215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C9J74_RS04220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C9J74_RS04235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C9J74_RS04245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C9J74_RS04250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C9J74_RS04255	COG0193	aminoacyl-tRNA hydrolase activity
C9J74_RS04260	COG0012	GTP binding
C9J74_RS04265	COG4206	TonB-dependent receptor
C9J74_RS04270	COG4242	Belongs to the peptidase S51 family
C9J74_RS04295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C9J74_RS04310	COG0250	Participates in transcription elongation, termination and antitermination
C9J74_RS04315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C9J74_RS04320	COG0081	regulation of translation
C9J74_RS04330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C9J74_RS04335	COG0222	ribosome binding
C9J74_RS04340	COG0085	RNA polymerase activity
C9J74_RS04345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C9J74_RS04350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C9J74_RS04355	COG0049	tRNA binding
C9J74_RS04360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C9J74_RS04365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C9J74_RS04370	COG0051	transcription antitermination factor activity, RNA binding
C9J74_RS04375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C9J74_RS04380	COG0088	Forms part of the polypeptide exit tunnel
C9J74_RS04385	COG0089	rRNA binding
C9J74_RS04390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C9J74_RS04395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C9J74_RS04400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C9J74_RS04405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C9J74_RS04410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C9J74_RS04415	COG0255	Belongs to the universal ribosomal protein uL29 family
C9J74_RS04420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C9J74_RS04425	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C9J74_RS04430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C9J74_RS04435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C9J74_RS04440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C9J74_RS04450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C9J74_RS04455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C9J74_RS04460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C9J74_RS04465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C9J74_RS04470	COG1841	ribosomal large subunit assembly
C9J74_RS04475	COG0200	Binds to the 23S rRNA
C9J74_RS04480	COG0201	protein transport
C9J74_RS04485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C9J74_RS04490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C9J74_RS04495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C9J74_RS04500	COG0202	RNA polymerase activity
C9J74_RS04505	COG0203	ribosomal protein L17
C9J74_RS04520	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C9J74_RS04535	COG0154	amidase activity
C9J74_RS04550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C9J74_RS04555	COG0039	L-malate dehydrogenase activity
C9J74_RS04560	COG0564	pseudouridine synthase activity
C9J74_RS04570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C9J74_RS04585	COG0625	glutathione transferase activity
C9J74_RS04595	COG1902	pentaerythritol trinitrate reductase activity
C9J74_RS04595	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9J74_RS04600	COG2364	Membrane
C9J74_RS04620	COG1187	pseudouridine synthase activity
C9J74_RS04640	COG1063	alcohol dehydrogenase
C9J74_RS04650	COG0588	phosphoglycerate mutase activity
C9J74_RS04655	COG0285	dihydrofolate synthase activity
C9J74_RS04675	COG2833	Protein of unknown function (DUF455)
C9J74_RS04685	COG3291	Pkd domain containing protein
C9J74_RS04690	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C9J74_RS04695	COG0671	phosphoesterase, PA-phosphatase related
C9J74_RS04700	COG0438	transferase activity, transferring glycosyl groups
C9J74_RS04705	COG4771	TonB-dependent receptor
C9J74_RS04710	COG4206	TonB-dependent receptor
C9J74_RS04715	COG0248	Ppx GppA phosphatase
C9J74_RS04720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C9J74_RS04735	COG4783	chaperone-mediated protein folding
C9J74_RS04755	COG0473	3-isopropylmalate dehydrogenase activity
C9J74_RS04825	COG0544	peptidyl-prolyl cis-trans isomerase activity
C9J74_RS04830	COG0740	serine-type endopeptidase activity
C9J74_RS04835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C9J74_RS04875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C9J74_RS04880	COG1388	LysM domain
C9J74_RS04880	COG3942	CHAP domain
C9J74_RS04885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C9J74_RS04895	COG0328	RNA-DNA hybrid ribonuclease activity
C9J74_RS04900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C9J74_RS04905	COG0631	protein serine/threonine phosphatase activity
C9J74_RS04920	COG0859	PFAM glycosyl transferase family 9
C9J74_RS04925	COG3642	lipopolysaccharide core region biosynthetic process
C9J74_RS04930	COG1234	tRNA 3'-trailer cleavage
C9J74_RS04945	COG2076	Multidrug Resistance protein
C9J74_RS04995	COG1432	Conserved Protein
C9J74_RS05030	COG1475	DNA binding
C9J74_RS05050	COG1715	Restriction endonuclease
C9J74_RS05070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C9J74_RS05080	COG0537	adenosine 5'-monophosphoramidase activity
C9J74_RS05100	COG0714	Associated with various cellular activities
C9J74_RS05115	COG1399	metal-binding, possibly nucleic acid-binding protein
C9J74_RS05120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C9J74_RS05125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C9J74_RS05135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C9J74_RS05140	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS05150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C9J74_RS05155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C9J74_RS05160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C9J74_RS05165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C9J74_RS05170	COG0470	DNA polymerase III
C9J74_RS05345	COG4774	siderophore transport
C9J74_RS05360	COG2223	nitrite transmembrane transporter activity
C9J74_RS05375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C9J74_RS05380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C9J74_RS05385	COG0697	spore germination
C9J74_RS05390	COG0583	DNA-binding transcription factor activity
C9J74_RS05395	COG0477	Major facilitator Superfamily
C9J74_RS05430	COG0583	DNA-binding transcription factor activity
C9J74_RS05455	COG0667	Aldo Keto reductase
C9J74_RS05475	COG0456	acetyltransferase
C9J74_RS05485	COG0519	Catalyzes the synthesis of GMP from XMP
C9J74_RS05490	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C9J74_RS05495	COG1678	Uncharacterized ACR, COG1678
C9J74_RS05500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C9J74_RS05505	COG0540	Belongs to the ATCase OTCase family
C9J74_RS05525	COG2239	Acts as a magnesium transporter
C9J74_RS05530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C9J74_RS05545	COG1660	Displays ATPase and GTPase activities
C9J74_RS05550	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C9J74_RS05555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9J74_RS05560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C9J74_RS05570	COG1137	ATPase activity
C9J74_RS05585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C9J74_RS05600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C9J74_RS05620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C9J74_RS05640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C9J74_RS05650	COG0628	permease
C9J74_RS05665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C9J74_RS05675	COG2261	transglycosylase associated protein
C9J74_RS05685	COG1555	photosystem II stabilization
C9J74_RS05705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C9J74_RS05710	COG1477	protein flavinylation
C9J74_RS05730	COG4771	TonB-dependent receptor
C9J74_RS05740	COG3128	pkhd-type hydroxylase
C9J74_RS05750	COG4774	siderophore transport
C9J74_RS05825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C9J74_RS05830	COG0719	Fe-S assembly protein
C9J74_RS05835	COG0396	ATPase activity
C9J74_RS05840	COG0719	Fe-S assembly protein
C9J74_RS05845	COG1959	2 iron, 2 sulfur cluster binding
C9J74_RS05855	COG0693	protein deglycase activity
C9J74_RS05880	COG1764	response to oxidative stress
C9J74_RS05885	COG0384	phenazine biosynthesis protein PhzF
C9J74_RS05890	COG0384	phenazine biosynthesis protein PhzF
C9J74_RS05895	COG0527	aspartate kinase activity
C9J74_RS05905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C9J74_RS05925	COG0142	geranyltranstransferase activity
C9J74_RS05930	COG0366	Alpha amylase catalytic
C9J74_RS05940	COG1082	Xylose isomerase domain protein TIM barrel
C9J74_RS05950	COG2190	(PTS) system
C9J74_RS05950	COG2211	Major facilitator Superfamily
C9J74_RS05980	COG1131	(ABC) transporter
C9J74_RS05985	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C9J74_RS06000	COG0629	single-stranded DNA binding
C9J74_RS06005	COG0583	DNA-binding transcription factor activity
C9J74_RS06040	COG2010	Cytochrome c
C9J74_RS06050	COG0673	inositol 2-dehydrogenase activity
C9J74_RS06055	COG2211	Major facilitator Superfamily
C9J74_RS06065	COG1609	Transcriptional regulator
C9J74_RS06070	COG3706	GGDEF domain
C9J74_RS06110	COG3655	Transcriptional regulator
C9J74_RS06115	COG1253	flavin adenine dinucleotide binding
C9J74_RS06120	COG1408	metallophosphoesterase
C9J74_RS06125	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C9J74_RS06145	COG2259	Doxx family
C9J74_RS06175	COG0477	Major facilitator Superfamily
C9J74_RS06190	COG1802	Transcriptional regulator
C9J74_RS06225	COG3052	prosthetic group binding
C9J74_RS06240	COG0579	oxidoreductase
C9J74_RS06265	COG3104	oligopeptide transport
C9J74_RS06270	COG1297	OPT oligopeptide transporter protein
C9J74_RS06275	COG1506	peptidase
C9J74_RS06275	COG0823	Involved in the tonB-independent uptake of proteins
C9J74_RS06290	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C9J74_RS06295	COG2894	cell division
C9J74_RS06300	COG0850	regulation of cytokinetic process
C9J74_RS06310	COG4585	Histidine kinase
C9J74_RS06315	COG2197	response regulator
C9J74_RS06355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C9J74_RS06370	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C9J74_RS06380	COG1595	DNA-templated transcription, initiation
C9J74_RS06390	COG1946	Acyl-CoA thioesterase
C9J74_RS06410	COG0824	Thioesterase
C9J74_RS06415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C9J74_RS06420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C9J74_RS06425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C9J74_RS06430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C9J74_RS06435	COG0268	Binds directly to 16S ribosomal RNA
C9J74_RS06440	COG0728	peptidoglycan biosynthetic process
C9J74_RS06445	COG0196	riboflavin kinase activity
C9J74_RS06450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C9J74_RS06460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C9J74_RS06485	COG4206	TonB-dependent receptor
C9J74_RS06505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C9J74_RS06520	COG3209	COG3209 Rhs family protein
C9J74_RS06570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C9J74_RS06575	COG1845	cytochrome c oxidase, subunit III
C9J74_RS06580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C9J74_RS06595	COG0326	Molecular chaperone. Has ATPase activity
C9J74_RS06615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C9J74_RS06630	COG0228	four-way junction DNA binding
C9J74_RS06635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C9J74_RS06640	COG0336	Belongs to the RNA methyltransferase TrmD family
C9J74_RS06645	COG0335	large ribosomal subunit rRNA binding
C9J74_RS06665	COG0534	Mate efflux family protein
C9J74_RS06690	COG0753	catalase activity
C9J74_RS06705	COG0840	transmembrane signaling receptor activity
C9J74_RS06710	COG3134	Outer membrane lipoprotein
C9J74_RS06730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS06750	COG4771	TonB-dependent receptor
C9J74_RS06755	COG0739	heme binding
C9J74_RS06765	COG0024	Methionine aminopeptidase
C9J74_RS06790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C9J74_RS06815	COG1647	Serine aminopeptidase, S33
C9J74_RS06840	COG2814	Major facilitator Superfamily
C9J74_RS06845	COG3706	GGDEF domain
C9J74_RS06870	COG0588	phosphoglycerate mutase activity
C9J74_RS06875	COG3590	peptidase
C9J74_RS06885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C9J74_RS06895	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C9J74_RS06900	COG0745	RESPONSE REGULATOR receiver
C9J74_RS06905	COG2205	protein histidine kinase activity
C9J74_RS06910	COG4452	Inner membrane protein CreD
C9J74_RS06925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C9J74_RS06930	COG0735	belongs to the Fur family
C9J74_RS06970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C9J74_RS07010	COG5001	Diguanylate cyclase
C9J74_RS07010	COG5002	protein histidine kinase activity
C9J74_RS07020	COG1187	pseudouridine synthase activity
C9J74_RS07035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C9J74_RS07060	COG1132	(ABC) transporter
C9J74_RS07115	COG1695	Transcriptional regulator
C9J74_RS07135	COG1981	membrane
C9J74_RS07140	COG0825	malonyl-CoA metabolic process
C9J74_RS07165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C9J74_RS07175	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C9J74_RS07180	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9J74_RS07185	COG0750	zinc metalloprotease
C9J74_RS07190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C9J74_RS07195	COG0575	Belongs to the CDS family
C9J74_RS07200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C9J74_RS07205	COG0233	cytoplasmic translational termination
C9J74_RS07210	COG0528	UMP kinase activity
C9J74_RS07220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C9J74_RS07225	COG0052	Belongs to the universal ribosomal protein uS2 family
C9J74_RS07245	COG3188	usher protein
C9J74_RS07265	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C9J74_RS07280	COG1393	Belongs to the ArsC family
C9J74_RS07285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C9J74_RS07295	COG0367	asparagine synthase
C9J74_RS07330	COG1566	PFAM secretion protein HlyD family protein
C9J74_RS07335	COG2814	Major facilitator Superfamily
C9J74_RS07350	COG0583	DNA-binding transcription factor activity
C9J74_RS07370	COG0557	exoribonuclease II activity
C9J74_RS07380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C9J74_RS07385	COG1538	Outer membrane efflux protein
C9J74_RS07390	COG1136	(ABC) transporter
C9J74_RS07390	COG0577	efflux transmembrane transporter activity
C9J74_RS07395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS07415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C9J74_RS07420	COG2259	Doxx family
C9J74_RS07430	COG3220	belongs to the UPF0276 family
C9J74_RS07440	COG0704	Plays a role in the regulation of phosphate uptake
C9J74_RS07450	COG0581	inorganic phosphate transmembrane transporter activity
C9J74_RS07455	COG0573	inorganic phosphate transmembrane transporter activity
C9J74_RS07460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C9J74_RS07465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C9J74_RS07475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C9J74_RS07485	COG1024	Enoyl-CoA hydratase
C9J74_RS07515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C9J74_RS07515	COG0116	Belongs to the methyltransferase superfamily
C9J74_RS07565	COG2733	membrane
C9J74_RS07575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C9J74_RS07580	COG1012	belongs to the aldehyde dehydrogenase family
C9J74_RS07590	COG0477	Major facilitator Superfamily
C9J74_RS07595	COG2703	oxygen carrier activity
C9J74_RS07620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C9J74_RS07630	COG0174	glutamine synthetase
C9J74_RS07640	COG2072	flavoprotein involved in K transport
C9J74_RS07645	COG3842	ATPase activity
C9J74_RS07650	COG1176	ABC-type spermidine putrescine transport system, permease component I
C9J74_RS07655	COG1177	transmembrane transport
C9J74_RS07660	COG1012	belongs to the aldehyde dehydrogenase family
C9J74_RS07675	COG4535	Mg2 and Co2 transporter CorC
C9J74_RS07695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C9J74_RS07700	COG1702	phosphate starvation-inducible protein PhoH
C9J74_RS07705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS07710	COG1131	(ABC) transporter
C9J74_RS07715	COG0842	Transport permease protein
C9J74_RS07720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C9J74_RS07735	COG0741	lytic transglycosylase activity
C9J74_RS07740	COG0723	plastoquinol--plastocyanin reductase activity
C9J74_RS07745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C9J74_RS07750	COG2857	Cytochrome c1
C9J74_RS07755	COG0625	glutathione transferase activity
C9J74_RS07760	COG2969	positive regulation of protein catabolic process
C9J74_RS07795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C9J74_RS07805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C9J74_RS07820	COG1611	Belongs to the LOG family
C9J74_RS07865	COG0556	nucleotide-excision repair
C9J74_RS07920	COG0811	peptide transport
C9J74_RS07935	COG1663	tetraacyldisaccharide 4'-kinase activity
C9J74_RS07940	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C9J74_RS07945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C9J74_RS07955	COG0322	excinuclease ABC activity
C9J74_RS08000	COG1136	(ABC) transporter
C9J74_RS08000	COG0577	efflux transmembrane transporter activity
C9J74_RS08045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C9J74_RS08075	COG0583	DNA-binding transcription factor activity
C9J74_RS08095	COG4977	sequence-specific DNA binding
C9J74_RS08095	COG1917	Cupin 2, conserved barrel domain protein
C9J74_RS08100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C9J74_RS08120	COG0348	domain, Protein
C9J74_RS08135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C9J74_RS08150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C9J74_RS08155	COG0069	glutamate synthase activity
C9J74_RS08185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9J74_RS08200	COG1253	flavin adenine dinucleotide binding
C9J74_RS08220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C9J74_RS08235	COG0504	CTP synthase activity
C9J74_RS08240	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C9J74_RS08255	COG0148	phosphopyruvate hydratase activity
C9J74_RS08260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C9J74_RS08265	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C9J74_RS08270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C9J74_RS08280	COG2840	Smr protein MutS2
C9J74_RS08285	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C9J74_RS08290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C9J74_RS08310	COG1534	Rna-binding protein
C9J74_RS08315	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C9J74_RS08320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C9J74_RS08330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C9J74_RS08335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C9J74_RS08340	COG1923	regulation of RNA biosynthetic process
C9J74_RS08345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C9J74_RS08350	COG1546	Belongs to the CinA family
C9J74_RS08355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C9J74_RS08360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C9J74_RS08365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C9J74_RS08370	COG2137	regulation of response to DNA damage stimulus
C9J74_RS08375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C9J74_RS08380	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C9J74_RS08405	COG4773	Receptor
C9J74_RS08420	COG1940	carbohydrate kinase activity
C9J74_RS08460	COG3540	Alkaline phosphatase
C9J74_RS08475	COG3258	Cytochrome c
C9J74_RS08490	COG2223	nitrite transmembrane transporter activity
C9J74_RS08505	COG1741	Belongs to the pirin family
C9J74_RS08510	COG0583	DNA-binding transcription factor activity
C9J74_RS08540	COG0352	thiamine-phosphate diphosphorylase activity
C9J74_RS08540	COG0351	phosphomethylpyrimidine kinase
C9J74_RS08555	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C9J74_RS08560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C9J74_RS08570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C9J74_RS08580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C9J74_RS08595	COG0617	tRNA 3'-terminal CCA addition
C9J74_RS08605	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C9J74_RS08610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C9J74_RS08620	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C9J74_RS08625	COG0166	Belongs to the GPI family
C9J74_RS08640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C9J74_RS08650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C9J74_RS08655	COG0671	phosphoesterase, PA-phosphatase related
C9J74_RS08665	COG0800	Aldolase
C9J74_RS08670	COG0129	dihydroxy-acid dehydratase activity
C9J74_RS08680	COG0837	glucose binding
C9J74_RS08685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C9J74_RS08705	COG2009	succinate dehydrogenase
C9J74_RS08710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C9J74_RS08715	COG1053	succinate dehydrogenase
C9J74_RS08735	COG4591	ABC-type transport system involved in lipoprotein release permease component
C9J74_RS08750	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C9J74_RS08755	COG1194	a g-specific adenine glycosylase
C9J74_RS08760	COG0552	protein localization to endoplasmic reticulum
C9J74_RS08775	COG0742	ribosomal rna small subunit methyltransferase
C9J74_RS08780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C9J74_RS08790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C9J74_RS08795	COG0405	Gamma-glutamyltransferase
C9J74_RS08800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C9J74_RS08820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C9J74_RS08840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C9J74_RS08850	COG0415	Belongs to the DNA photolyase family
C9J74_RS08855	COG2885	chlorophyll binding
C9J74_RS08860	COG0583	DNA-binding transcription factor activity
C9J74_RS08975	COG1733	regulation of RNA biosynthetic process
C9J74_RS08990	COG0582	viral genome integration into host DNA
C9J74_RS09005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C9J74_RS09020	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9J74_RS09025	COG0735	belongs to the Fur family
C9J74_RS09035	COG0583	DNA-binding transcription factor activity
C9J74_RS09040	COG0497	DNA recombination
C9J74_RS09045	COG1420	regulation of RNA biosynthetic process
C9J74_RS09050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C9J74_RS09055	COG0443	Heat shock 70 kDa protein
C9J74_RS09060	COG0484	heat shock protein binding
C9J74_RS09070	COG2207	Transcriptional regulator
C9J74_RS09075	COG2223	nitrite transmembrane transporter activity
C9J74_RS09085	COG0287	Prephenate dehydrogenase
C9J74_RS09085	COG1605	Chorismate mutase
C9J74_RS09095	COG1132	(ABC) transporter
C9J74_RS09115	COG5001	Diguanylate cyclase
C9J74_RS09125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C9J74_RS09130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C9J74_RS09135	COG0343	queuine tRNA-ribosyltransferase activity
C9J74_RS09140	COG1862	Preprotein translocase
C9J74_RS09150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C9J74_RS09160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C9J74_RS09170	COG2081	HI0933 family
C9J74_RS09175	COG4681	YaeQ
C9J74_RS09180	COG0564	pseudouridine synthase activity
C9J74_RS09195	COG0625	glutathione transferase activity
C9J74_RS09200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C9J74_RS09210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C9J74_RS09215	COG0513	Belongs to the DEAD box helicase family
C9J74_RS09225	COG0583	DNA-binding transcription factor activity
C9J74_RS09230	COG0488	(ABC) transporter
C9J74_RS09255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9J74_RS09270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C9J74_RS09275	COG2957	Belongs to the agmatine deiminase family
C9J74_RS09285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C9J74_RS09290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C9J74_RS09300	COG0776	regulation of translation
C9J74_RS09310	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C9J74_RS09315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C9J74_RS09325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C9J74_RS09330	COG0183	Belongs to the thiolase family
C9J74_RS09335	COG1250	3-hydroxyacyl-CoA dehydrogenase
C9J74_RS09335	COG1024	Enoyl-CoA hydratase
C9J74_RS09345	COG0105	UTP biosynthetic process
C9J74_RS09350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C9J74_RS09360	COG1426	Protein conserved in bacteria
C9J74_RS09370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9J74_RS09375	COG1160	GTP binding
C9J74_RS09385	COG0583	DNA-binding transcription factor activity
C9J74_RS09390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C9J74_RS09395	COG0475	glutathione-regulated potassium exporter activity
C9J74_RS09395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C9J74_RS09415	COG0519	Catalyzes the synthesis of GMP from XMP
C9J74_RS09415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C9J74_RS09440	COG0583	DNA-binding transcription factor activity
C9J74_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS09500	COG0640	Transcriptional regulator
C9J74_RS09520	COG4716	Myosin-crossreactive antigen
C9J74_RS09555	COG0431	NADPH-dependent FMN reductase
C9J74_RS09565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9J74_RS09570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9J74_RS09575	COG1473	amidohydrolase
C9J74_RS09585	COG1126	abc transporter atp-binding protein
C9J74_RS09590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9J74_RS09610	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C9J74_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS09630	COG1309	transcriptional regulator
C9J74_RS09645	COG0697	spore germination
C9J74_RS09650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C9J74_RS09655	COG0167	dihydroorotate dehydrogenase activity
C9J74_RS09670	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
C9J74_RS09685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C9J74_RS09690	COG0489	protein tyrosine kinase activity
C9J74_RS09690	COG3206	protein involved in exopolysaccharide biosynthesis
C9J74_RS09695	COG2244	polysaccharide biosynthetic process
C9J74_RS09700	COG0438	transferase activity, transferring glycosyl groups
C9J74_RS09720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9J74_RS09760	COG0456	acetyltransferase
C9J74_RS09760	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C9J74_RS09785	COG0745	RESPONSE REGULATOR receiver
C9J74_RS09790	COG0784	Response regulator, receiver
C9J74_RS09790	COG4191	Histidine kinase
C9J74_RS09795	COG2205	protein histidine kinase activity
C9J74_RS09795	COG4999	Histidine kinase
C9J74_RS09795	COG3850	Histidine kinase
C9J74_RS09795	COG3437	response regulator, receiver
C9J74_RS09800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C9J74_RS09865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C9J74_RS09870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C9J74_RS09875	COG0124	histidyl-tRNA synthetase
C9J74_RS09890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C9J74_RS09895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C9J74_RS09900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C9J74_RS09905	COG0131	Imidazoleglycerol-phosphate dehydratase
C9J74_RS09905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C9J74_RS09910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C9J74_RS09915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C9J74_RS09920	COG0107	imidazoleglycerol-phosphate synthase activity
C9J74_RS09925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C9J74_RS09925	COG0140	phosphoribosyl-ATP diphosphatase activity
C9J74_RS09945	COG1446	asparaginase
C9J74_RS09950	COG3142	Participates in the control of copper homeostasis
C9J74_RS09965	COG0789	Transcriptional regulator
C9J74_RS09985	COG3537	Alpha-1,2-mannosidase
C9J74_RS09990	COG1609	Transcriptional regulator
C9J74_RS10000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C9J74_RS10015	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C9J74_RS10020	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C9J74_RS10025	COG0235	Class ii aldolase
C9J74_RS10040	COG0531	amino acid
C9J74_RS10045	COG0531	amino acid
C9J74_RS10055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C9J74_RS10060	COG0277	FAD linked oxidase domain protein
C9J74_RS10075	COG2205	protein histidine kinase activity
C9J74_RS10080	COG0745	RESPONSE REGULATOR receiver
C9J74_RS10085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS10090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9J74_RS10105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C9J74_RS10150	COG2249	NAD(P)H dehydrogenase (quinone) activity
C9J74_RS10165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C9J74_RS10170	COG0505	Belongs to the CarA family
C9J74_RS10175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C9J74_RS10180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C9J74_RS10200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C9J74_RS10205	COG4676	Protein conserved in bacteria
C9J74_RS10230	COG1012	belongs to the aldehyde dehydrogenase family
C9J74_RS10250	COG0784	Response regulator, receiver
C9J74_RS10250	COG2205	protein histidine kinase activity
C9J74_RS10250	COG2198	Histidine kinase
C9J74_RS10255	COG1024	Enoyl-CoA hydratase
C9J74_RS10260	COG0318	PFAM AMP-dependent synthetase and ligase
C9J74_RS10265	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C9J74_RS10270	COG1012	belongs to the aldehyde dehydrogenase family
C9J74_RS10275	COG1309	transcriptional regulator
C9J74_RS10280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C9J74_RS10315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C9J74_RS10325	COG0840	transmembrane signaling receptor activity
C9J74_RS10330	COG0840	transmembrane signaling receptor activity
C9J74_RS10340	COG0835	chemotaxis
C9J74_RS10345	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C9J74_RS10350	COG0840	transmembrane signaling receptor activity
C9J74_RS10360	COG0745	RESPONSE REGULATOR receiver
C9J74_RS10370	COG0835	chemotaxis
C9J74_RS10380	COG1360	Flagellar Motor Protein
C9J74_RS10385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C9J74_RS10390	COG0784	Response regulator, receiver
C9J74_RS10390	COG2198	Histidine kinase
C9J74_RS10390	COG0643	Histidine kinase
C9J74_RS10395	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C9J74_RS10420	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C9J74_RS10425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C9J74_RS10445	COG1987	bacterial-type flagellum assembly
C9J74_RS10455	COG3190	flagellar
C9J74_RS10505	COG1677	Flagellar hook-basal body complex protein FliE
C9J74_RS10530	COG2197	response regulator
C9J74_RS10550	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C9J74_RS10590	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C9J74_RS10600	COG4787	bacterial-type flagellum-dependent cell motility
C9J74_RS10615	COG1558	bacterial-type flagellum-dependent cell motility
C9J74_RS10620	COG1815	bacterial-type flagellum-dependent cell motility
C9J74_RS10625	COG0784	Response regulator, receiver
C9J74_RS10625	COG0835	chemotaxis
C9J74_RS10645	COG5002	protein histidine kinase activity
C9J74_RS10680	COG2915	High frequency lysogenization protein hflD homolog
C9J74_RS10685	COG0482	sulfurtransferase activity
C9J74_RS10700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C9J74_RS10710	COG0542	response to heat
C9J74_RS10740	COG0492	ferredoxin-NADP+ reductase activity
C9J74_RS10745	COG1674	ftsk spoiiie
C9J74_RS10760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C9J74_RS10775	COG2819	hydrolase of the alpha beta superfamily
C9J74_RS10785	COG4558	Periplasmic binding protein
C9J74_RS10790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C9J74_RS10795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C9J74_RS10805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C9J74_RS10820	COG2205	protein histidine kinase activity
C9J74_RS10820	COG0784	Response regulator, receiver
C9J74_RS10820	COG2198	Histidine kinase
C9J74_RS10825	COG2197	response regulator
C9J74_RS10835	COG1136	(ABC) transporter
C9J74_RS10835	COG0577	efflux transmembrane transporter activity
C9J74_RS10865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C9J74_RS10875	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C9J74_RS10890	COG1595	DNA-templated transcription, initiation
C9J74_RS10910	COG0784	Response regulator, receiver
C9J74_RS10915	COG4251	negative regulation of phosphorylation
C9J74_RS10930	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C9J74_RS10940	COG0456	acetyltransferase
C9J74_RS10940	COG0454	-acetyltransferase
C9J74_RS11000	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9J74_RS11035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C9J74_RS11130	COG0010	Belongs to the arginase family
C9J74_RS11185	COG2132	Multicopper oxidase
C9J74_RS11255	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C9J74_RS11265	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C9J74_RS11270	COG2080	2 iron, 2 sulfur cluster binding
C9J74_RS11405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C9J74_RS11410	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C9J74_RS11415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C9J74_RS11420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C9J74_RS11425	COG2080	2 iron, 2 sulfur cluster binding
C9J74_RS11445	COG0583	DNA-binding transcription factor activity
C9J74_RS11465	COG1595	DNA-templated transcription, initiation
C9J74_RS11470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C9J74_RS11480	COG1309	transcriptional regulator
C9J74_RS11510	COG3685	Protein conserved in bacteria
C9J74_RS11555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C9J74_RS11575	COG1063	alcohol dehydrogenase
C9J74_RS11610	COG1609	Transcriptional regulator
C9J74_RS11615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C9J74_RS11615	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9J74_RS11620	COG1105	Belongs to the carbohydrate kinase PfkB family
C9J74_RS11625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9J74_RS11625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9J74_RS11635	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C9J74_RS11645	COG4771	TonB-dependent receptor
C9J74_RS11650	COG0738	Major facilitator superfamily
C9J74_RS11655	COG1609	Transcriptional regulator
C9J74_RS11675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9J74_RS11690	COG2828	Protein conserved in bacteria
C9J74_RS11695	COG0583	DNA-binding transcription factor activity
C9J74_RS11735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C9J74_RS11740	COG0583	DNA-binding transcription factor activity
C9J74_RS11765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C9J74_RS11780	COG0596	Alpha beta hydrolase
C9J74_RS11790	COG2205	protein histidine kinase activity
C9J74_RS11800	COG0318	PFAM AMP-dependent synthetase and ligase
C9J74_RS11810	COG2186	Transcriptional regulator
C9J74_RS11830	COG2271	Major facilitator Superfamily
C9J74_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS11845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C9J74_RS11870	COG1404	Belongs to the peptidase S8 family
C9J74_RS11885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C9J74_RS11905	COG0583	DNA-binding transcription factor activity
C9J74_RS11930	COG2204	response regulator
C9J74_RS12025	COG2199	diguanylate cyclase activity
C9J74_RS12035	COG0577	efflux transmembrane transporter activity
C9J74_RS12035	COG1136	(ABC) transporter
C9J74_RS12040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS12050	COG0745	RESPONSE REGULATOR receiver
C9J74_RS12055	COG2205	protein histidine kinase activity
C9J74_RS12065	COG3214	Protein conserved in bacteria
C9J74_RS12075	COG4774	siderophore transport
C9J74_RS12100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C9J74_RS12110	COG4191	Histidine kinase
C9J74_RS12115	COG4566	intracellular signal transduction
C9J74_RS12190	COG0477	Major facilitator Superfamily
C9J74_RS12230	COG0583	DNA-binding transcription factor activity
C9J74_RS12235	COG0656	L-ascorbic acid biosynthetic process
C9J74_RS12270	COG5002	protein histidine kinase activity
C9J74_RS12275	COG0583	DNA-binding transcription factor activity
C9J74_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS12310	COG3537	Alpha-1,2-mannosidase
C9J74_RS12330	COG0477	Major facilitator Superfamily
C9J74_RS12345	COG3920	Histidine kinase
C9J74_RS12345	COG2202	Pas domain
C9J74_RS12390	COG1335	isochorismatase
C9J74_RS12395	COG1335	isochorismatase
C9J74_RS12425	COG0811	peptide transport
C9J74_RS12565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C9J74_RS12570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C9J74_RS12580	COG0840	transmembrane signaling receptor activity
C9J74_RS12585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C9J74_RS12590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C9J74_RS12595	COG4149	molybdate abc transporter
C9J74_RS12600	COG0725	ABC transporter, periplasmic molybdate-binding protein
C9J74_RS12605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C9J74_RS12615	COG0746	molybdenum cofactor guanylyltransferase activity
C9J74_RS12620	COG0314	molybdopterin synthase activity
C9J74_RS12630	COG0303	'Molybdopterin
C9J74_RS12635	COG0521	Mo-molybdopterin cofactor biosynthetic process
C9J74_RS12635	COG0315	cyclic pyranopterin monophosphate synthase activity
C9J74_RS12640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C9J74_RS12680	COG2207	Transcriptional regulator
C9J74_RS12720	COG2205	protein histidine kinase activity
C9J74_RS12730	COG2194	sulfuric ester hydrolase activity
C9J74_RS12750	COG2885	chlorophyll binding
C9J74_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS12775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C9J74_RS12775	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C9J74_RS12785	COG3433	isochorismatase activity
C9J74_RS12785	COG1535	isochorismatase
C9J74_RS12790	COG1021	2,3-dihydroxybenzoate-AMP ligase
C9J74_RS12795	COG1169	isochorismate synthase
C9J74_RS12805	COG2409	Drug exporters of the RND superfamily
C9J74_RS12810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9J74_RS12870	COG1914	H( )-stimulated, divalent metal cation uptake system
C9J74_RS12885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C9J74_RS12890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C9J74_RS12895	COG3321	synthase
C9J74_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS12895	COG0604	alcohol dehydrogenase
C9J74_RS12900	COG4206	TonB-dependent receptor
C9J74_RS12905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C9J74_RS12940	COG0583	DNA-binding transcription factor activity
C9J74_RS12950	COG4772	TonB-dependent receptor
C9J74_RS13015	COG4964	Belongs to the GSP D family
C9J74_RS13070	COG2814	Major facilitator Superfamily
C9J74_RS13080	COG1228	amidohydrolase
C9J74_RS13090	COG1335	isochorismatase
C9J74_RS13105	COG3850	Histidine kinase
C9J74_RS13110	COG2197	response regulator
C9J74_RS13115	COG2814	Major facilitator Superfamily
C9J74_RS13125	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C9J74_RS13135	COG0583	DNA-binding transcription factor activity
C9J74_RS13150	COG3161	chorismate lyase activity
C9J74_RS13190	COG0277	FAD linked oxidase domain protein
C9J74_RS13195	COG1304	FMN binding
C9J74_RS13200	COG2186	Transcriptional regulator
C9J74_RS13210	COG1285	pathogenesis
C9J74_RS13295	COG0587	DNA-directed DNA polymerase activity
C9J74_RS13310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C9J74_RS13315	COG0519	Catalyzes the synthesis of GMP from XMP
C9J74_RS13315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C9J74_RS13330	COG1595	DNA-templated transcription, initiation
C9J74_RS13340	COG1629	transport
C9J74_RS13340	COG4206	TonB-dependent receptor
C9J74_RS13370	COG0531	amino acid
C9J74_RS13385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C9J74_RS13395	COG0789	Transcriptional regulator
C9J74_RS13485	COG2183	response to ionizing radiation
C9J74_RS13510	COG3243	poly(R)-hydroxyalkanoic acid synthase
C9J74_RS13525	COG2226	methyltransferase
C9J74_RS13525	COG1073	alpha beta
C9J74_RS13530	COG0534	Mate efflux family protein
C9J74_RS13550	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C9J74_RS13560	COG0668	transmembrane transport
C9J74_RS13565	COG1902	pentaerythritol trinitrate reductase activity
C9J74_RS13575	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C9J74_RS13580	COG0590	tRNA wobble adenosine to inosine editing
C9J74_RS13585	COG1733	regulation of RNA biosynthetic process
C9J74_RS13590	COG2249	NAD(P)H dehydrogenase (quinone) activity
C9J74_RS13670	COG3702	type iv secretory pathway
C9J74_RS13690	COG2948	multi-organism process
C9J74_RS13700	COG3736	Type IV secretory pathway, component VirB8
C9J74_RS13710	COG3505	Type IV secretory pathway VirD4
C9J74_RS13725	COG2814	Major facilitator Superfamily
C9J74_RS13730	COG0789	Transcriptional regulator
C9J74_RS13760	COG0784	Response regulator, receiver
C9J74_RS13760	COG4191	Histidine kinase
C9J74_RS13775	COG4774	siderophore transport
C9J74_RS13790	COG3133	Outer membrane lipoprotein
C9J74_RS13810	COG1733	regulation of RNA biosynthetic process
C9J74_RS13815	COG0604	alcohol dehydrogenase
C9J74_RS13830	COG0210	DNA helicase
C9J74_RS13850	COG0583	DNA-binding transcription factor activity
C9J74_RS13855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C9J74_RS13865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C9J74_RS13880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C9J74_RS13885	COG1605	Chorismate mutase
C9J74_RS13885	COG0077	Prephenate dehydratase
C9J74_RS13890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C9J74_RS13925	COG1228	amidohydrolase
C9J74_RS13940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C9J74_RS13990	COG2957	Belongs to the agmatine deiminase family
C9J74_RS13995	COG0583	DNA-binding transcription factor activity
C9J74_RS14065	COG4993	Dehydrogenase
C9J74_RS14075	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C9J74_RS14085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C9J74_RS14095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C9J74_RS14100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C9J74_RS14115	COG0359	binds to the 23S rRNA
C9J74_RS14120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C9J74_RS14125	COG0360	Binds together with S18 to 16S ribosomal RNA
C9J74_RS14130	COG0316	Belongs to the HesB IscA family
C9J74_RS14135	COG0017	Asparaginyl-tRNA synthetase
C9J74_RS14155	COG0288	reversible hydration of carbon dioxide
C9J74_RS14165	COG3844	kynureninase activity
C9J74_RS14170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9J74_RS14175	COG2925	Exonuclease
C9J74_RS14200	COG2902	Dehydrogenase
C9J74_RS14210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS14215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9J74_RS14225	COG1960	acyl-CoA dehydrogenase activity
C9J74_RS14240	COG0646	methionine synthase
C9J74_RS14240	COG1410	methionine synthase
C9J74_RS14255	COG2900	Belongs to the SlyX family
C9J74_RS14270	COG0386	Belongs to the glutathione peroxidase family
C9J74_RS14280	COG1725	Transcriptional regulator
C9J74_RS14285	COG1131	(ABC) transporter
C9J74_RS14320	COG2850	peptidyl-arginine hydroxylation
C9J74_RS14330	COG0567	Dehydrogenase, E1 component
C9J74_RS14355	COG3540	Alkaline phosphatase
C9J74_RS14365	COG0305	Participates in initiation and elongation during chromosome replication
C9J74_RS14385	COG0625	glutathione transferase activity
C9J74_RS14405	COG0084	hydrolase, TatD family'
C9J74_RS14410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C9J74_RS14445	COG0625	glutathione transferase activity
C9J74_RS14465	COG1595	DNA-templated transcription, initiation
C9J74_RS14470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C9J74_RS14485	COG0386	Belongs to the glutathione peroxidase family
C9J74_RS14490	COG0339	signal peptide processing
C9J74_RS14495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C9J74_RS14510	COG0705	Rhomboid family
C9J74_RS14515	COG3104	oligopeptide transport
C9J74_RS14525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C9J74_RS14530	COG4290	ribonuclease
C9J74_RS14545	COG0316	Belongs to the HesB IscA family
C9J74_RS14545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C9J74_RS14550	COG2154	pterin-4-alpha-carbinolamine dehydratase
C9J74_RS14560	COG0428	transporter
C9J74_RS14570	COG1530	ribonuclease E activity
C9J74_RS14585	COG0395	ABC-type sugar transport system, permease component
C9J74_RS14615	COG0271	Belongs to the BolA IbaG family
C9J74_RS14620	COG2350	Protein conserved in bacteria
C9J74_RS14625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C9J74_RS14630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C9J74_RS14635	COG1187	pseudouridine synthase activity
C9J74_RS14645	COG2814	Major facilitator Superfamily
C9J74_RS14665	COG0436	Aminotransferase
C9J74_RS14670	COG4133	protoheme IX ABC transporter activity
C9J74_RS14690	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C9J74_RS14705	COG4235	cytochrome complex assembly
C9J74_RS14705	COG3088	subunit of a heme lyase
C9J74_RS14715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C9J74_RS14725	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C9J74_RS14730	COG4988	ABC transporter
C9J74_RS14740	COG1294	oxidase, subunit
C9J74_RS14770	COG1649	PFAM Uncharacterised BCR, COG1649
C9J74_RS14770	COG0726	polysaccharide deacetylase
C9J74_RS14775	COG1215	transferase activity, transferring glycosyl groups
C9J74_RS14785	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C9J74_RS14800	COG0165	Argininosuccinate lyase
C9J74_RS14805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C9J74_RS14815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C9J74_RS14820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C9J74_RS14825	COG0137	argininosuccinate synthase activity
C9J74_RS14830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C9J74_RS14845	COG2166	iron-sulfur cluster assembly
C9J74_RS14865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C9J74_RS14885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C9J74_RS14890	COG0402	S-adenosylhomocysteine deaminase activity
C9J74_RS14895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C9J74_RS14900	COG1509	lysine 2,3-aminomutase activity
C9J74_RS14905	COG3300	MHYT domain
C9J74_RS14905	COG5001	Diguanylate cyclase
C9J74_RS14925	COG0501	Belongs to the peptidase M48B family
C9J74_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS14955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C9J74_RS14960	COG0860	N-Acetylmuramoyl-L-alanine amidase
C9J74_RS14965	COG0802	atpase or kinase
C9J74_RS14970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C9J74_RS14970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C9J74_RS14975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C9J74_RS14980	COG1570	exodeoxyribonuclease VII activity
C9J74_RS14990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C9J74_RS15005	COG4771	TonB-dependent receptor
C9J74_RS15010	COG1309	transcriptional regulator
C9J74_RS15045	COG2169	Transcriptional regulator
C9J74_RS15045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C9J74_RS15050	COG2130	NADP-dependent
C9J74_RS15075	COG1960	acyl-CoA dehydrogenase activity
C9J74_RS15085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C9J74_RS15120	COG2076	Multidrug Resistance protein
C9J74_RS15125	COG5487	UPF0391 membrane protein
C9J74_RS15130	COG1280	lysine exporter protein (LysE YggA)
C9J74_RS15135	COG1794	racemase activity, acting on amino acids and derivatives
C9J74_RS15175	COG0776	regulation of translation
C9J74_RS15180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9J74_RS15180	COG0072	phenylalanine-tRNA ligase activity
C9J74_RS15185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C9J74_RS15190	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C9J74_RS15195	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C9J74_RS15200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C9J74_RS15205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C9J74_RS15245	COG1185	polyribonucleotide nucleotidyltransferase activity
C9J74_RS15250	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C9J74_RS15260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C9J74_RS15265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C9J74_RS15270	COG0195	Participates in both transcription termination and antitermination
C9J74_RS15275	COG0779	Required for maturation of 30S ribosomal subunits
C9J74_RS15290	COG1007	ATP synthesis coupled electron transport
C9J74_RS15305	COG0713	ATP synthesis coupled electron transport
C9J74_RS15315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9J74_RS15320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C9J74_RS15335	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C9J74_RS15340	COG0649	NAD binding
C9J74_RS15345	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9J74_RS15350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9J74_RS15355	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9J74_RS15370	COG0149	triose-phosphate isomerase activity
C9J74_RS15380	COG3083	sulfuric ester hydrolase activity
C9J74_RS15385	COG0438	transferase activity, transferring glycosyl groups
C9J74_RS15390	COG0726	polysaccharide deacetylase
C9J74_RS15395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C9J74_RS15400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C9J74_RS15405	COG0159	tryptophan synthase activity
C9J74_RS15415	COG0133	tryptophan synthase activity
C9J74_RS15450	COG0135	phosphoribosylanthranilate isomerase activity
C9J74_RS15455	COG0101	tRNA pseudouridine synthase activity
C9J74_RS15470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C9J74_RS15475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C9J74_RS15480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C9J74_RS15485	COG2890	protein-(glutamine-N5) methyltransferase activity
C9J74_RS15490	COG1999	signal sequence binding
C9J74_RS15495	COG0688	phosphatidylethanolamine metabolic process
C9J74_RS15510	COG0433	COG0433 Predicted ATPase
C9J74_RS15515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C9J74_RS15525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C9J74_RS15530	COG0412	Dienelactone hydrolase
C9J74_RS15540	COG0717	Belongs to the dCTP deaminase family
C9J74_RS15550	COG0489	protein tyrosine kinase activity
C9J74_RS15555	COG4771	TonB-dependent receptor
C9J74_RS15560	COG4771	TonB-dependent receptor
C9J74_RS15565	COG4771	TonB-dependent receptor
C9J74_RS15570	COG3590	peptidase
C9J74_RS15600	COG0697	spore germination
C9J74_RS15610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C9J74_RS15615	COG2311	Membrane
C9J74_RS15620	COG1047	Peptidyl-prolyl cis-trans
C9J74_RS15625	COG0791	NLP P60 protein
C9J74_RS15630	COG0791	NLP P60 protein
C9J74_RS15635	COG1301	dicarboxylic acid transport
C9J74_RS15655	COG1722	exodeoxyribonuclease VII activity
C9J74_RS15660	COG0142	geranyltranstransferase activity
C9J74_RS15670	COG0312	modulator of DNA gyrase
C9J74_RS15675	COG3028	Belongs to the UPF0307 family
C9J74_RS15680	COG0312	modulator of DNA gyrase
C9J74_RS15700	COG2968	Membrane
C9J74_RS15710	COG4771	TonB-dependent receptor
C9J74_RS15720	COG2755	lipolytic protein G-D-S-L family
C9J74_RS15720	COG0657	acetylesterase activity
C9J74_RS15730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C9J74_RS15740	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C9J74_RS15755	COG0495	leucyl-tRNA aminoacylation
C9J74_RS15765	COG3118	belongs to the thioredoxin family
C9J74_RS15775	COG5001	Diguanylate cyclase
C9J74_RS15775	COG4251	negative regulation of phosphorylation
C9J74_RS15775	COG3706	GGDEF domain
C9J74_RS15775	COG2203	Gaf domain
C9J74_RS15780	COG1943	Transposase
C9J74_RS15805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C9J74_RS15815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C9J74_RS15820	COG0346	lactoylglutathione lyase activity
C9J74_RS15830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9J74_RS15830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9J74_RS15840	COG2878	Part of a membrane complex involved in electron transport
C9J74_RS15845	COG0251	oxidation-reduction process
C9J74_RS15850	COG0392	lysyltransferase activity
C9J74_RS15850	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C9J74_RS15880	COG2824	Alkylphosphonate utilization operon protein PhnA
C9J74_RS15885	COG1077	Cell shape determining protein MreB Mrl
C9J74_RS15930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C9J74_RS15935	COG3122	Protein conserved in bacteria
C9J74_RS15940	COG1451	nucleotide metabolic process
C9J74_RS15950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C9J74_RS15970	COG0183	Belongs to the thiolase family
C9J74_RS15985	COG1960	acyl-CoA dehydrogenase activity
C9J74_RS15995	COG1793	dna ligase
C9J74_RS16000	COG1201	RNA secondary structure unwinding
C9J74_RS16015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9J74_RS16020	COG1278	Cold shock
C9J74_RS16025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C9J74_RS16030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C9J74_RS16035	COG1472	Belongs to the glycosyl hydrolase 3 family
C9J74_RS16040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C9J74_RS16045	COG2954	triphosphatase activity
C9J74_RS16050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C9J74_RS16055	COG0745	RESPONSE REGULATOR receiver
C9J74_RS16060	COG1381	Involved in DNA repair and RecF pathway recombination
C9J74_RS16065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C9J74_RS16080	COG0681	Belongs to the peptidase S26 family
C9J74_RS16085	COG0481	GTPase activity
C9J74_RS16090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C9J74_RS16105	COG1250	3-hydroxyacyl-CoA dehydrogenase
C9J74_RS16105	COG1024	Enoyl-CoA hydratase
C9J74_RS16110	COG1741	Belongs to the pirin family
C9J74_RS16115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C9J74_RS16125	COG1741	Belongs to the pirin family
C9J74_RS16135	COG1966	Carbon starvation protein
C9J74_RS16140	COG2879	small protein
C9J74_RS16150	COG2205	protein histidine kinase activity
C9J74_RS16155	COG0745	RESPONSE REGULATOR receiver
C9J74_RS16190	COG2814	Major facilitator Superfamily
C9J74_RS16195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C9J74_RS16195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C9J74_RS16205	COG1113	amino acid transport
C9J74_RS16210	COG1917	Cupin 2, conserved barrel domain protein
C9J74_RS16210	COG2207	Transcriptional regulator
C9J74_RS16215	COG0753	catalase activity
C9J74_RS16230	COG1376	ErfK ybiS ycfS ynhG family protein
C9J74_RS16235	COG0739	heme binding
C9J74_RS16245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C9J74_RS16255	COG0330	HflC and HflK could
C9J74_RS16260	COG0330	HflC and HflK could
C9J74_RS16265	COG0604	alcohol dehydrogenase
C9J74_RS16280	COG0678	peroxiredoxin activity
C9J74_RS16290	COG4953	penicillin-binding protein 1C
C9J74_RS16295	COG2373	Large extracellular alpha-helical protein
C9J74_RS16300	COG2079	MmgE PrpD family protein
C9J74_RS16305	COG2828	Protein conserved in bacteria
C9J74_RS16315	COG3609	addiction module antidote protein, CC2985 family
C9J74_RS16335	COG3829	transcription factor binding
C9J74_RS16350	COG0259	pyridoxamine-phosphate oxidase activity
C9J74_RS16365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C9J74_RS16385	COG0477	Major facilitator Superfamily
C9J74_RS16410	COG3038	cytochrome b561
C9J74_RS16425	COG1760	l-serine dehydratase
C9J74_RS16430	COG2267	carboxylic ester hydrolase activity
C9J74_RS16435	COG0527	aspartate kinase activity
C9J74_RS16435	COG0460	homoserine dehydrogenase
C9J74_RS16440	COG0626	cystathionine gamma-synthase activity
C9J74_RS16445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C9J74_RS16450	COG0739	heme binding
C9J74_RS16455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C9J74_RS16460	COG1272	protein, Hemolysin III
C9J74_RS16465	COG2982	Protein involved in outer membrane biogenesis
C9J74_RS16475	COG0463	Glycosyl transferase, family 2
C9J74_RS16480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C9J74_RS16485	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C9J74_RS16495	COG4206	TonB-dependent receptor
C9J74_RS16500	COG1309	transcriptional regulator
C9J74_RS16510	COG1960	acyl-CoA dehydrogenase activity
C9J74_RS16540	COG0583	DNA-binding transcription factor activity
C9J74_RS16550	COG0509	glycine decarboxylation via glycine cleavage system
C9J74_RS16555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C9J74_RS16565	COG0330	HflC and HflK could
C9J74_RS16575	COG1742	UPF0060 membrane protein
C9J74_RS16580	COG3956	TIGRFAM MazG family protein
C9J74_RS16590	COG0494	nUDIX hydrolase
C9J74_RS16600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C9J74_RS16615	COG0784	Response regulator, receiver
C9J74_RS16615	COG2198	Histidine kinase
C9J74_RS16615	COG0643	Histidine kinase
C9J74_RS16620	COG0840	transmembrane signaling receptor activity
C9J74_RS16625	COG0835	chemotaxis
C9J74_RS16640	COG0189	ligase activity
C9J74_RS16655	COG1199	ATP-dependent helicase activity
C9J74_RS16665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C9J74_RS16670	COG1215	transferase activity, transferring glycosyl groups
C9J74_RS16685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C9J74_RS16695	COG1643	Atp-dependent helicase
C9J74_RS16700	COG0783	Belongs to the Dps family
C9J74_RS16705	COG0514	ATP-dependent DNA helicase (RecQ)
C9J74_RS16865	COG0789	Transcriptional regulator
C9J74_RS16985	COG0358	DNA primase activity
C9J74_RS17145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C9J74_RS17150	COG0602	queuosine metabolic process
C9J74_RS17160	COG2885	chlorophyll binding
C9J74_RS17165	COG0823	Involved in the tonB-independent uptake of proteins
C9J74_RS17180	COG0811	peptide transport
C9J74_RS17185	COG0824	Thioesterase
C9J74_RS17190	COG2255	four-way junction helicase activity
C9J74_RS17205	COG0632	four-way junction helicase activity
C9J74_RS17210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C9J74_RS17215	COG0217	transcriptional regulatory protein
C9J74_RS17235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C9J74_RS17265	COG0488	(ABC) transporter
C9J74_RS17285	COG4651	solute:proton antiporter activity
C9J74_RS17285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C9J74_RS17295	COG0745	RESPONSE REGULATOR receiver
C9J74_RS17300	COG2205	protein histidine kinase activity
C9J74_RS17315	COG0542	response to heat
C9J74_RS17335	COG0028	Belongs to the TPP enzyme family
C9J74_RS17360	COG3387	PFAM Glycoside hydrolase 15-related
C9J74_RS17365	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C9J74_RS17370	COG3011	Protein conserved in bacteria
C9J74_RS17385	COG0564	pseudouridine synthase activity
C9J74_RS17390	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9J74_RS17400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C9J74_RS17400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C9J74_RS17425	COG1132	(ABC) transporter
C9J74_RS17430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C9J74_RS17435	COG0045	succinate-CoA ligase (ADP-forming) activity
C9J74_RS17465	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C9J74_RS17480	COG0745	RESPONSE REGULATOR receiver
C9J74_RS17495	COG0189	ligase activity
C9J74_RS17525	COG3240	lipase activity
C9J74_RS17525	COG4625	pathogenesis
C9J74_RS17535	COG2022	thiamine diphosphate biosynthetic process
C9J74_RS17540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C9J74_RS17545	COG0471	metal ion transport
C9J74_RS17545	COG3273	potassium ion transport
C9J74_RS17565	COG1970	mechanosensitive ion channel activity
C9J74_RS17575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C9J74_RS17580	COG1115	amino acid carrier protein
C9J74_RS17590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9J74_RS17595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS17625	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C9J74_RS17635	COG3588	fructose-bisphosphate aldolase
C9J74_RS17640	COG0469	pyruvate kinase activity
C9J74_RS17650	COG0126	phosphoglycerate kinase activity
C9J74_RS17665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C9J74_RS17710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C9J74_RS17715	COG1301	dicarboxylic acid transport
C9J74_RS17725	COG2304	oxidoreductase activity
C9J74_RS17745	COG0714	Associated with various cellular activities
C9J74_RS17775	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C9J74_RS17840	COG0254	rRNA binding
C9J74_RS17850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C9J74_RS17860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C9J74_RS17865	COG1758	RNA polymerase activity
C9J74_RS17875	COG3383	formate dehydrogenase (NAD+) activity
C9J74_RS17875	COG0243	molybdopterin cofactor binding
C9J74_RS17880	COG0243	molybdopterin cofactor binding
C9J74_RS17880	COG3383	formate dehydrogenase (NAD+) activity
C9J74_RS17885	COG0437	4 iron, 4 sulfur cluster binding
C9J74_RS17890	COG2864	formate dehydrogenase
C9J74_RS17900	COG1921	L-seryl-tRNASec selenium transferase activity
C9J74_RS17905	COG3276	selenocysteine insertion sequence binding
C9J74_RS17915	COG0709	Synthesizes selenophosphate from selenide and ATP
C9J74_RS17930	COG1561	YicC-like family, N-terminal region
C9J74_RS17935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C9J74_RS17940	COG0346	lactoylglutathione lyase activity
C9J74_RS17950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C9J74_RS17965	COG0006	proline dipeptidase activity
C9J74_RS17970	COG0006	proline dipeptidase activity
C9J74_RS17975	COG3079	Belongs to the UPF0149 family
C9J74_RS17995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C9J74_RS18005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C9J74_RS18015	COG2912	Transglutaminase-like superfamily
C9J74_RS18020	COG1773	rubredoxin
C9J74_RS18030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C9J74_RS18045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C9J74_RS18050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C9J74_RS18060	COG4221	oxidoreductase activity
C9J74_RS18085	COG0671	phosphoesterase, PA-phosphatase related
C9J74_RS18095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C9J74_RS18100	COG0563	adenylate kinase activity
C9J74_RS18120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C9J74_RS18130	COG0848	biopolymer transport protein
C9J74_RS18140	COG2832	Protein of unknown function (DUF454)
C9J74_RS18175	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C9J74_RS18185	COG4771	TonB-dependent receptor
C9J74_RS18195	COG0745	RESPONSE REGULATOR receiver
C9J74_RS18205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C9J74_RS18210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C9J74_RS18215	COG0405	Gamma-glutamyltransferase
C9J74_RS18220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C9J74_RS18240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C9J74_RS18245	COG2226	methyltransferase
C9J74_RS18260	COG0473	3-isopropylmalate dehydrogenase activity
C9J74_RS18300	COG1538	Outer membrane efflux protein
C9J74_RS18310	COG1519	Transferase
C9J74_RS18315	COG1560	Kdo2-lipid A biosynthetic process
C9J74_RS18360	COG1301	dicarboxylic acid transport
C9J74_RS18370	COG4191	Histidine kinase
C9J74_RS18385	COG0642	Histidine kinase
C9J74_RS18400	COG2851	Citrate transporter
C9J74_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS18425	COG1162	GTPase activity
C9J74_RS18430	COG0436	Aminotransferase
C9J74_RS18450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C9J74_RS18465	COG1228	amidohydrolase
C9J74_RS18470	COG0804	urea catabolic process
C9J74_RS18480	COG1307	EDD domain protein, DegV family
C9J74_RS18495	COG2203	Gaf domain
C9J74_RS18495	COG3706	GGDEF domain
C9J74_RS18495	COG4251	negative regulation of phosphorylation
C9J74_RS18495	COG5001	Diguanylate cyclase
C9J74_RS18500	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C9J74_RS18525	COG1902	pentaerythritol trinitrate reductase activity
C9J74_RS18555	COG0583	DNA-binding transcription factor activity
C9J74_RS18560	COG1064	alcohol dehydrogenase
C9J74_RS18580	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C9J74_RS18585	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C9J74_RS18595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C9J74_RS18600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C9J74_RS18615	COG1522	sequence-specific DNA binding
C9J74_RS18625	COG4773	Receptor
C9J74_RS18630	COG4206	TonB-dependent receptor
C9J74_RS18650	COG0617	tRNA 3'-terminal CCA addition
C9J74_RS18670	COG3468	outer membrane autotransporter barrel domain protein
C9J74_RS18680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C9J74_RS18685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C9J74_RS18690	COG1609	Transcriptional regulator
C9J74_RS18700	COG0837	glucose binding
C9J74_RS18710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C9J74_RS18730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C9J74_RS18740	COG4191	Histidine kinase
C9J74_RS18745	COG0784	Response regulator, receiver
C9J74_RS18750	COG4251	negative regulation of phosphorylation
C9J74_RS18755	COG2823	Periplasmic or secreted lipoprotein
C9J74_RS18760	COG0673	inositol 2-dehydrogenase activity
C9J74_RS18765	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C9J74_RS18785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C9J74_RS18790	COG0321	lipoyl(octanoyl) transferase activity
C9J74_RS18795	COG2921	Belongs to the UPF0250 family
C9J74_RS18810	COG1686	Belongs to the peptidase S11 family
C9J74_RS18815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C9J74_RS18820	COG2951	lytic endotransglycosylase activity
C9J74_RS18825	COG0772	Belongs to the SEDS family
C9J74_RS18830	COG0772	Belongs to the SEDS family
C9J74_RS18835	COG0768	penicillin binding
C9J74_RS18845	COG1792	Involved in formation and maintenance of cell shape
C9J74_RS18850	COG1077	Cell shape determining protein MreB Mrl
C9J74_RS18855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C9J74_RS18870	COG0308	aminopeptidase N
C9J74_RS18875	COG2226	methyltransferase
C9J74_RS18905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9J74_RS18920	COG0673	inositol 2-dehydrogenase activity
C9J74_RS18930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C9J74_RS18945	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C9J74_RS18955	COG2832	Protein of unknown function (DUF454)
C9J74_RS18965	COG0436	Aminotransferase
C9J74_RS18970	COG1505	serine-type exopeptidase activity
C9J74_RS19005	COG0697	spore germination
C9J74_RS19010	COG1666	GTP binding
C9J74_RS19040	COG0339	signal peptide processing
C9J74_RS19050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C9J74_RS19065	COG4206	TonB-dependent receptor
C9J74_RS19085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C9J74_RS19095	COG1136	(ABC) transporter
C9J74_RS19105	COG1136	(ABC) transporter
C9J74_RS19105	COG0577	efflux transmembrane transporter activity
C9J74_RS19120	COG4191	Histidine kinase
C9J74_RS19130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C9J74_RS19140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C9J74_RS19145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C9J74_RS19150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C9J74_RS19155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C9J74_RS19160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C9J74_RS19165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C9J74_RS19175	COG0356	it plays a direct role in the translocation of protons across the membrane
C9J74_RS19190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C9J74_RS19195	COG0508	dehydrogenase complex catalyzes the overall conversion of
C9J74_RS19215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C9J74_RS19220	COG1464	Belongs to the NlpA lipoprotein family
C9J74_RS19240	COG0181	hydroxymethylbilane synthase activity
C9J74_RS19250	COG2972	Histidine kinase
C9J74_RS19250	COG0745	RESPONSE REGULATOR receiver
C9J74_RS19270	COG4771	TonB-dependent receptor
C9J74_RS19280	COG0840	transmembrane signaling receptor activity
C9J74_RS19310	COG0477	Major facilitator Superfamily
C9J74_RS19345	COG0625	glutathione transferase activity
C9J74_RS19360	COG2259	Doxx family
C9J74_RS19390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C9J74_RS19400	COG0758	DNA mediated transformation
C9J74_RS19400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C9J74_RS19440	COG1196	nuclear chromosome segregation
C9J74_RS19680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C9J74_RS19685	COG1490	D-aminoacyl-tRNA deacylase activity
C9J74_RS19735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C9J74_RS19735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C9J74_RS19740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C9J74_RS19745	COG0242	peptide deformylase activity
C9J74_RS19755	COG0758	DNA mediated transformation
C9J74_RS19760	COG2922	Belongs to the Smg family
C9J74_RS19770	COG1714	RDD family
C9J74_RS19775	COG1754	DNA topoisomerase type I activity
C9J74_RS19775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C9J74_RS19780	COG0009	L-threonylcarbamoyladenylate synthase
C9J74_RS19795	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS19805	COG0616	signal peptide processing
C9J74_RS19810	COG0534	Mate efflux family protein
C9J74_RS19825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C9J74_RS19830	COG0625	glutathione transferase activity
C9J74_RS19840	COG1252	NADH dehydrogenase
C9J74_RS19855	COG2860	membrane
C9J74_RS19860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C9J74_RS19880	COG1846	Transcriptional regulator
C9J74_RS19910	COG0459	protein refolding
C9J74_RS19915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C9J74_RS19920	COG2356	endonuclease I
C9J74_RS19925	COG1324	tolerance protein
C9J74_RS19935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C9J74_RS19945	COG0840	transmembrane signaling receptor activity
C9J74_RS19965	COG4585	Histidine kinase
C9J74_RS19985	COG0583	DNA-binding transcription factor activity
C9J74_RS19995	COG1785	Belongs to the alkaline phosphatase family
C9J74_RS20000	COG1686	Belongs to the peptidase S11 family
C9J74_RS20010	COG2249	NAD(P)H dehydrogenase (quinone) activity
C9J74_RS20020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C9J74_RS20030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C9J74_RS20040	COG0511	ligase activity, forming carbon-carbon bonds
C9J74_RS20045	COG0439	Biotin carboxylase
C9J74_RS20060	COG2264	protein methyltransferase activity
C9J74_RS20070	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C9J74_RS20075	COG4589	Belongs to the CDS family
C9J74_RS20080	COG0204	Acyl-transferase
C9J74_RS20090	COG0671	phosphoesterase, PA-phosphatase related
C9J74_RS20090	COG2453	phosphatase
C9J74_RS20095	COG2267	carboxylic ester hydrolase activity
C9J74_RS20100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C9J74_RS20105	COG0138	bifunctional purine biosynthesis protein purh
C9J74_RS20115	COG0151	Belongs to the GarS family
C9J74_RS20130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C9J74_RS20135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C9J74_RS20140	COG2201	protein-glutamate methylesterase activity
C9J74_RS20145	COG2177	Part of the ABC transporter FtsEX involved in
C9J74_RS20150	COG2884	Cell division ATP-binding protein ftsE
C9J74_RS20165	COG3118	belongs to the thioredoxin family
C9J74_RS20170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C9J74_RS20175	COG3706	GGDEF domain
C9J74_RS20185	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C9J74_RS20225	COG1652	LysM domain
C9J74_RS20230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C9J74_RS20230	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C9J74_RS20235	COG1473	amidohydrolase
C9J74_RS20240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS20245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9J74_RS20250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9J74_RS20255	COG1289	transmembrane transporter activity
C9J74_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS20265	COG2814	Major facilitator Superfamily
C9J74_RS20295	COG0316	Belongs to the HesB IscA family
C9J74_RS20320	COG0784	Response regulator, receiver
C9J74_RS20320	COG5002	protein histidine kinase activity
C9J74_RS20320	COG2205	protein histidine kinase activity
C9J74_RS20335	COG1051	belongs to the nudix hydrolase family
C9J74_RS20350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C9J74_RS20355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C9J74_RS20360	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C9J74_RS20370	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C9J74_RS20375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C9J74_RS20380	COG0730	response to heat
C9J74_RS20390	COG0134	indole-3-glycerol-phosphate synthase activity
C9J74_RS20395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C9J74_RS20415	COG1597	lipid kinase activity
C9J74_RS20430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C9J74_RS20435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C9J74_RS20445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C9J74_RS20445	COG2111	Na H antiporter
C9J74_RS20450	COG1006	Multisubunit Na H antiporter MnhC subunit
C9J74_RS20455	COG0651	ATP synthesis coupled electron transport
C9J74_RS20460	COG1863	multisubunit Na H antiporter MnhE subunit
C9J74_RS20465	COG2212	antiporter activity
C9J74_RS20470	COG1320	monovalent cation:proton antiporter activity
C9J74_RS20475	COG0530	calcium, potassium:sodium antiporter activity
C9J74_RS20490	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C9J74_RS20515	COG3104	oligopeptide transport
C9J74_RS20520	COG3483	tryptophan 2,3-dioxygenase activity
C9J74_RS20550	COG2378	regulation of single-species biofilm formation
C9J74_RS20565	COG2354	Protein conserved in bacteria
C9J74_RS20570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C9J74_RS20575	COG1368	sulfuric ester hydrolase activity
C9J74_RS20580	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C9J74_RS20580	COG3264	Mechanosensitive ion channel
C9J74_RS20595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C9J74_RS20630	COG1166	arginine decarboxylase activity
C9J74_RS20635	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C9J74_RS20655	COG2960	long-chain fatty acid transporting porin activity
C9J74_RS20690	COG0606	chelatase, subunit chli
C9J74_RS20710	COG0561	phosphatase activity
C9J74_RS20715	COG3932	Exopolysaccharide synthesis, ExoD
C9J74_RS20740	COG1999	signal sequence binding
C9J74_RS20745	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C9J74_RS20750	COG1845	cytochrome c oxidase, subunit III
C9J74_RS20760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C9J74_RS20765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C9J74_RS20780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C9J74_RS20810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C9J74_RS20830	COG2031	fatty acid transporter
C9J74_RS20855	COG0673	inositol 2-dehydrogenase activity
C9J74_RS20865	COG1501	Belongs to the glycosyl hydrolase 31 family
C9J74_RS20870	COG2222	sugar isomerase
C9J74_RS20875	COG1940	carbohydrate kinase activity
C9J74_RS20885	COG1349	DNA-binding transcription factor activity
C9J74_RS20890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C9J74_RS20895	COG2814	Major facilitator Superfamily
C9J74_RS20940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C9J74_RS20945	COG0156	8-amino-7-oxononanoate synthase activity
C9J74_RS20950	COG2267	carboxylic ester hydrolase activity
C9J74_RS20970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C9J74_RS20995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9J74_RS21000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9J74_RS21005	COG2205	protein histidine kinase activity
C9J74_RS21010	COG0745	RESPONSE REGULATOR receiver
C9J74_RS21015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C9J74_RS21040	COG0714	Associated with various cellular activities
C9J74_RS21055	COG0754	glutathionylspermidine amidase activity
C9J74_RS21065	COG0129	dihydroxy-acid dehydratase activity
C9J74_RS21070	COG1199	ATP-dependent helicase activity
C9J74_RS21080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C9J74_RS21100	COG3781	membrane
C9J74_RS21130	COG0625	glutathione transferase activity
C9J74_RS21150	COG2207	Transcriptional regulator
C9J74_RS21165	COG4555	ABC transporter
C9J74_RS21195	COG0543	2 iron, 2 sulfur cluster binding
C9J74_RS21195	COG0633	Ferredoxin
C9J74_RS21200	COG1131	(ABC) transporter
C9J74_RS21205	COG0842	Transport permease protein
C9J74_RS21215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C9J74_RS21225	COG0084	hydrolase, TatD family'
C9J74_RS21230	COG1643	Atp-dependent helicase
C9J74_RS21240	COG1187	pseudouridine synthase activity
C9J74_RS21250	COG0667	Aldo Keto reductase
C9J74_RS21270	COG1690	Belongs to the RtcB family
C9J74_RS21280	COG1959	2 iron, 2 sulfur cluster binding
C9J74_RS21290	COG0583	DNA-binding transcription factor activity
C9J74_RS21295	COG2814	Major facilitator Superfamily
C9J74_RS21300	COG0656	L-ascorbic acid biosynthetic process
C9J74_RS21305	COG2267	carboxylic ester hydrolase activity
C9J74_RS21315	COG0045	succinate-CoA ligase (ADP-forming) activity
C9J74_RS21315	COG1042	CoA-binding domain protein
C9J74_RS21315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C9J74_RS21320	COG2239	Acts as a magnesium transporter
C9J74_RS21335	COG3177	Filamentation induced by cAMP protein fic
C9J74_RS21335	COG0666	response to abiotic stimulus
C9J74_RS21340	COG3100	YcgL domain-containing protein
C9J74_RS21345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C9J74_RS21350	COG1028	Short-chain dehydrogenase reductase Sdr
C9J74_RS21385	COG2986	histidine ammonia-lyase
C9J74_RS21400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C9J74_RS21415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C9J74_RS21430	COG1294	oxidase, subunit
C9J74_RS21435	COG1271	oxidase subunit
C9J74_RS21465	COG1595	DNA-templated transcription, initiation
C9J74_RS21500	COG0408	coproporphyrinogen oxidase activity
C9J74_RS21510	COG2323	membrane
C9J74_RS21525	COG0589	response to stress
C9J74_RS21540	COG0210	DNA helicase
C9J74_RS21550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C9J74_RS21555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C9J74_RS21560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C9J74_RS21575	COG0251	oxidation-reduction process
C9J74_RS21610	COG0463	Glycosyl transferase, family 2
C9J74_RS21625	COG1475	DNA binding
C9J74_RS21630	COG1192	Involved in chromosome partitioning
C9J74_RS21635	COG0357	Ribosomal RNA small subunit methyltransferase G
C9J74_RS21640	COG2091	lysine biosynthetic process via aminoadipic acid
C9J74_RS21680	COG1943	Transposase
C9J74_RS21685	COG1971	Probably functions as a manganese efflux pump
C9J74_RS21700	COG2911	Protein conserved in bacteria
C9J74_RS21705	COG0729	surface antigen
C9J74_RS21715	COG0752	glycyl-tRNA synthetase alpha subunit
C9J74_RS21720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C9J74_RS21725	COG0519	Catalyzes the synthesis of GMP from XMP
C9J74_RS21725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C9J74_RS21735	COG0805	protein transport
C9J74_RS21745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C9J74_RS21755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C9J74_RS21765	COG0840	transmembrane signaling receptor activity
C9J74_RS21820	COG3135	benzoate transporter
C9J74_RS21835	COG2951	lytic endotransglycosylase activity
C9J74_RS21840	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C9J74_RS21845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C9J74_RS21850	COG3706	GGDEF domain
C9J74_RS21880	COG0302	gtp cyclohydrolase
C9J74_RS21895	COG1566	PFAM secretion protein HlyD family protein
C9J74_RS21905	COG1289	transmembrane transporter activity
C9J74_RS21920	COG1074	ATP-dependent DNA helicase activity
C9J74_RS21925	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C9J74_RS21930	COG1127	ABC transporter
C9J74_RS21935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C9J74_RS21940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C9J74_RS21955	COG2853	Lipoprotein
C9J74_RS21960	COG0386	Belongs to the glutathione peroxidase family
C9J74_RS21970	COG1322	Protein conserved in bacteria
C9J74_RS21980	COG0604	alcohol dehydrogenase
C9J74_RS21985	COG0583	DNA-binding transcription factor activity
C9J74_RS22005	COG0667	Aldo Keto reductase
C9J74_RS22010	COG0531	amino acid
C9J74_RS22030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C9J74_RS22035	COG0861	Integral membrane protein TerC family
C9J74_RS22045	COG0584	glycerophosphoryl diester phosphodiesterase
C9J74_RS22060	COG0706	membrane insertase activity
C9J74_RS22065	COG0594	ribonuclease P activity
C9J74_RS22070	COG0230	Belongs to the bacterial ribosomal protein bL34 family