locus-tag	class	description
H7X90_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7X90_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7X90_RS00020	COG0187	DNA topoisomerase II activity
H7X90_RS00025	COG1266	CAAX protease self-immunity
H7X90_RS00030	COG0501	Belongs to the peptidase M48B family
H7X90_RS00105	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7X90_RS00115	COG4772	TonB-dependent receptor
H7X90_RS00150	COG0800	Aldolase
H7X90_RS00170	COG3186	Phenylalanine-4-hydroxylase
H7X90_RS00175	COG1522	sequence-specific DNA binding
H7X90_RS00185	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7X90_RS00215	COG1122	ATPase activity
H7X90_RS00235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7X90_RS00240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H7X90_RS00260	COG0210	DNA helicase
H7X90_RS00270	COG3132	Protein of unknown function, DUF480
H7X90_RS00275	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H7X90_RS00280	COG0284	orotidine-5'-phosphate decarboxylase activity
H7X90_RS00290	COG2937	Belongs to the GPAT DAPAT family
H7X90_RS00300	COG0037	tRNA processing
H7X90_RS00305	COG2974	May be involved in recombination
H7X90_RS00315	COG1803	Methylglyoxal synthase
H7X90_RS00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7X90_RS00320	COG2205	protein histidine kinase activity
H7X90_RS00325	COG0493	'glutamate synthase
H7X90_RS00330	COG0069	glutamate synthase activity
H7X90_RS00330	COG0067	glutamate synthase
H7X90_RS00330	COG0070	glutamate synthase
H7X90_RS00350	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS00365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7X90_RS00390	COG1205	dead DEAH box helicase
H7X90_RS00390	COG1111	helicase
H7X90_RS00425	COG0714	Associated with various cellular activities
H7X90_RS00445	COG0312	modulator of DNA gyrase
H7X90_RS00455	COG3550	peptidyl-serine autophosphorylation
H7X90_RS00475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7X90_RS00495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7X90_RS00520	COG1881	PFAM PEBP family protein
H7X90_RS00535	COG1968	undecaprenyl-diphosphatase activity
H7X90_RS00540	COG0174	glutamine synthetase
H7X90_RS00545	COG0347	Belongs to the P(II) protein family
H7X90_RS00550	COG0004	ammonium transporteR
H7X90_RS00555	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7X90_RS00565	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7X90_RS00580	COG3852	Histidine kinase
H7X90_RS00585	COG2204	response regulator
H7X90_RS00590	COG2032	superoxide dismutase activity
H7X90_RS00595	COG2032	superoxide dismutase activity
H7X90_RS00610	COG0183	Belongs to the thiolase family
H7X90_RS00645	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7X90_RS00650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7X90_RS00670	COG0798	PFAM Bile acid sodium symporter
H7X90_RS00685	COG0431	NADPH-dependent FMN reductase
H7X90_RS00725	COG2837	iron assimilation
H7X90_RS00765	COG2197	response regulator
H7X90_RS00770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7X90_RS00770	COG2205	protein histidine kinase activity
H7X90_RS00775	COG3474	cytochrome
H7X90_RS00785	COG1960	acyl-CoA dehydrogenase activity
H7X90_RS00790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7X90_RS00800	COG0612	Peptidase, M16
H7X90_RS00810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7X90_RS00815	COG0596	Alpha beta hydrolase
H7X90_RS00825	COG0318	PFAM AMP-dependent synthetase and ligase
H7X90_RS00830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7X90_RS00840	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7X90_RS00850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7X90_RS00865	COG1215	transferase activity, transferring glycosyl groups
H7X90_RS00870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7X90_RS00900	COG0339	signal peptide processing
H7X90_RS00915	COG0681	Belongs to the peptidase S26 family
H7X90_RS00920	COG2814	Major facilitator Superfamily
H7X90_RS00925	COG0583	DNA-binding transcription factor activity
H7X90_RS00930	COG0583	DNA-binding transcription factor activity
H7X90_RS00935	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7X90_RS00940	COG2224	Isocitrate lyase
H7X90_RS00945	COG3706	GGDEF domain
H7X90_RS00970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7X90_RS00975	COG1960	acyl-CoA dehydrogenase activity
H7X90_RS00995	COG0697	spore germination
H7X90_RS01005	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7X90_RS01015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7X90_RS01025	COG1280	lysine exporter protein (LysE YggA)
H7X90_RS01030	COG1607	acyl-coa hydrolase
H7X90_RS01040	COG1902	pentaerythritol trinitrate reductase activity
H7X90_RS01055	COG1335	isochorismatase
H7X90_RS01060	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7X90_RS01070	COG1051	belongs to the nudix hydrolase family
H7X90_RS01070	COG1056	cytidyltransferase-related domain
H7X90_RS01075	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7X90_RS01085	COG3800	Transcriptional regulator
H7X90_RS01085	COG1396	sequence-specific DNA binding
H7X90_RS01095	COG1960	acyl-CoA dehydrogenase activity
H7X90_RS01100	COG1024	Enoyl-CoA hydratase
H7X90_RS01105	COG1024	Enoyl-CoA hydratase
H7X90_RS01115	COG1764	response to oxidative stress
H7X90_RS01140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7X90_RS01160	COG3228	Belongs to the MtfA family
H7X90_RS01170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H7X90_RS01170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H7X90_RS01175	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H7X90_RS01200	COG3657	addiction module killer protein
H7X90_RS01240	COG3237	CsbD-like
H7X90_RS01250	COG0180	Tryptophanyl-tRNA synthetase
H7X90_RS01275	COG0477	Major facilitator Superfamily
H7X90_RS01285	COG4152	abc transporter atp-binding protein
H7X90_RS01300	COG0697	spore germination
H7X90_RS01315	COG1136	(ABC) transporter
H7X90_RS01315	COG0577	efflux transmembrane transporter activity
H7X90_RS01325	COG1136	(ABC) transporter
H7X90_RS01345	COG4585	Histidine kinase
H7X90_RS01350	COG2197	response regulator
H7X90_RS01365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7X90_RS01380	COG0628	permease
H7X90_RS01400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7X90_RS01415	COG5507	3-demethylubiquinone-9 3-methyltransferase
H7X90_RS01430	COG2197	response regulator
H7X90_RS01445	COG2814	Major facilitator Superfamily
H7X90_RS01450	COG0583	DNA-binding transcription factor activity
H7X90_RS01455	COG4807	Protein conserved in bacteria
H7X90_RS01465	COG4221	oxidoreductase activity
H7X90_RS01475	COG0018	arginyl-trna synthetase
H7X90_RS01510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7X90_RS01520	COG0602	queuosine metabolic process
H7X90_RS01555	COG0210	DNA helicase
H7X90_RS01605	COG2197	response regulator
H7X90_RS01610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7X90_RS01630	COG2205	protein histidine kinase activity
H7X90_RS01640	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H7X90_RS01645	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H7X90_RS01660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7X90_RS01665	COG0708	Exodeoxyribonuclease III
H7X90_RS01670	COG2223	nitrite transmembrane transporter activity
H7X90_RS01685	COG0739	heme binding
H7X90_RS01690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7X90_RS01750	COG2234	aminopeptidase activity
H7X90_RS01760	COG4942	peptidase
H7X90_RS01765	COG0793	Belongs to the peptidase S41A family
H7X90_RS01800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7X90_RS01845	COG0109	protoheme IX farnesyltransferase activity
H7X90_RS01865	COG0358	DNA primase activity
H7X90_RS01870	COG1295	ribonuclease BN
H7X90_RS01885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7X90_RS01895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7X90_RS01900	COG0668	transmembrane transport
H7X90_RS01915	COG2133	pyrroloquinoline quinone binding
H7X90_RS01920	COG4682	membrane
H7X90_RS01930	COG0531	amino acid
H7X90_RS01940	COG1737	Transcriptional regulator
H7X90_RS01945	COG4948	Mandelate Racemase Muconate Lactonizing
H7X90_RS01965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7X90_RS01995	COG5383	Protein conserved in bacteria
H7X90_RS02005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7X90_RS02010	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7X90_RS02040	COG0778	Nitroreductase
H7X90_RS02045	COG2353	YceI-like domain
H7X90_RS02065	COG2375	cellular response to nickel ion
H7X90_RS02085	COG2131	deaminase
H7X90_RS02160	COG2267	carboxylic ester hydrolase activity
H7X90_RS02215	COG2801	Transposase and inactivated derivatives
H7X90_RS02215	COG3415	Transposase
H7X90_RS02230	COG0488	(ABC) transporter
H7X90_RS02235	COG0583	DNA-binding transcription factor activity
H7X90_RS02245	COG2814	Major facilitator Superfamily
H7X90_RS02250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H7X90_RS02255	COG1113	amino acid transport
H7X90_RS02260	COG0741	lytic transglycosylase activity
H7X90_RS02275	COG3795	YCII-related domain
H7X90_RS02285	COG2764	glyoxalase bleomycin resistance protein dioxygenase
H7X90_RS02295	COG5507	3-demethylubiquinone-9 3-methyltransferase
H7X90_RS02300	COG4941	Belongs to the sigma-70 factor family
H7X90_RS02330	COG3275	phosphorelay sensor kinase activity
H7X90_RS02335	COG3279	Response regulator of the LytR AlgR family
H7X90_RS02355	COG1309	transcriptional regulator
H7X90_RS02370	COG3590	peptidase
H7X90_RS02375	COG5001	Diguanylate cyclase
H7X90_RS02380	COG0583	DNA-binding transcription factor activity
H7X90_RS02390	COG3384	dioxygenase
H7X90_RS02395	COG0025	NhaP-type Na H and K H
H7X90_RS02420	COG1360	Flagellar Motor Protein
H7X90_RS02450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7X90_RS02465	COG5002	protein histidine kinase activity
H7X90_RS02480	COG2813	Specifically methylates the guanine in position
H7X90_RS02485	COG1187	pseudouridine synthase activity
H7X90_RS02490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7X90_RS02500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7X90_RS02505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7X90_RS02520	COG0583	DNA-binding transcription factor activity
H7X90_RS02525	COG2226	methyltransferase
H7X90_RS02550	COG1956	GAF domain-containing protein
H7X90_RS02555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7X90_RS02560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7X90_RS02565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7X90_RS02570	COG0785	Cytochrome C biogenesis protein
H7X90_RS02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7X90_RS02575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7X90_RS02580	COG0745	RESPONSE REGULATOR receiver
H7X90_RS02585	COG2205	protein histidine kinase activity
H7X90_RS02590	COG2205	protein histidine kinase activity
H7X90_RS02595	COG0745	RESPONSE REGULATOR receiver
H7X90_RS02600	COG0367	asparagine synthase
H7X90_RS02610	COG0720	synthase
H7X90_RS02625	COG0513	Belongs to the DEAD box helicase family
H7X90_RS02635	COG0625	glutathione transferase activity
H7X90_RS02680	COG0626	cystathionine gamma-synthase activity
H7X90_RS02705	COG0438	transferase activity, transferring glycosyl groups
H7X90_RS02710	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H7X90_RS02720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7X90_RS02760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7X90_RS02770	COG2086	electron transfer activity
H7X90_RS02800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7X90_RS02805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7X90_RS02850	COG1216	Glycosyl transferase, family 2
H7X90_RS02865	COG1127	ABC transporter
H7X90_RS02870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7X90_RS02885	COG0442	prolyl-tRNA aminoacylation
H7X90_RS02895	COG1183	phosphatidylcholine synthase activity
H7X90_RS02905	COG0456	acetyltransferase
H7X90_RS02915	COG0525	valine-tRNA ligase activity
H7X90_RS02925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7X90_RS02935	COG0795	lipopolysaccharide-transporting ATPase activity
H7X90_RS02950	COG4974	Belongs to the 'phage' integrase family
H7X90_RS02955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7X90_RS02965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7X90_RS02965	COG0047	phosphoribosylformylglycinamidine synthase activity
H7X90_RS02970	COG5295	Hep Hag repeat protein
H7X90_RS02975	COG1404	Belongs to the peptidase S8 family
H7X90_RS02980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7X90_RS02985	COG1459	type II secretion system
H7X90_RS02990	COG2165	general secretion pathway protein
H7X90_RS02995	COG4970	Tfp pilus assembly protein FimT
H7X90_RS03000	COG2165	general secretion pathway protein
H7X90_RS03005	COG4795	General secretion pathway protein
H7X90_RS03010	COG3156	type II secretion system protein K
H7X90_RS03015	COG3166	PFAM Fimbrial assembly family protein
H7X90_RS03030	COG1450	Type ii and iii secretion system protein
H7X90_RS03040	COG0463	Glycosyl transferase, family 2
H7X90_RS03045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7X90_RS03055	COG3539	Fimbrial protein
H7X90_RS03075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7X90_RS03085	COG1215	transferase activity, transferring glycosyl groups
H7X90_RS03100	COG2252	PERMEase
H7X90_RS03105	COG0488	(ABC) transporter
H7X90_RS03115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7X90_RS03135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7X90_RS03140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7X90_RS03140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7X90_RS03175	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7X90_RS03180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7X90_RS03190	COG3121	Chaperone
H7X90_RS03205	COG3188	usher protein
H7X90_RS03215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7X90_RS03215	COG2755	lipolytic protein G-D-S-L family
H7X90_RS03220	COG0277	FAD linked oxidase domain protein
H7X90_RS03225	COG1988	membrane-bound metal-dependent
H7X90_RS03270	COG2001	Belongs to the MraZ family
H7X90_RS03275	COG0275	rRNA processing
H7X90_RS03280	COG3116	cell division
H7X90_RS03290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7X90_RS03295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7X90_RS03315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7X90_RS03320	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7X90_RS03325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7X90_RS03335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7X90_RS03340	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7X90_RS03350	COG0739	heme binding
H7X90_RS03355	COG0653	protein targeting
H7X90_RS03360	COG0494	nUDIX hydrolase
H7X90_RS03370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7X90_RS03380	COG3275	phosphorelay sensor kinase activity
H7X90_RS03385	COG3279	Response regulator of the LytR AlgR family
H7X90_RS03405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7X90_RS03410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7X90_RS03425	COG1607	acyl-coa hydrolase
H7X90_RS03430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7X90_RS03460	COG4106	trans-aconitate 2-methyltransferase activity
H7X90_RS03465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7X90_RS03485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7X90_RS03490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7X90_RS03495	COG0667	Aldo Keto reductase
H7X90_RS03505	COG4771	TonB-dependent receptor
H7X90_RS03520	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7X90_RS03525	COG4181	ATPase activity
H7X90_RS03540	COG0642	Histidine kinase
H7X90_RS03550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7X90_RS03555	COG0861	Integral membrane protein TerC family
H7X90_RS03560	COG2814	Major facilitator Superfamily
H7X90_RS03565	COG1704	LemA family
H7X90_RS03580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7X90_RS03585	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7X90_RS03595	COG3738	Protein conserved in bacteria
H7X90_RS03600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7X90_RS03605	COG2967	ApaG domain
H7X90_RS03610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7X90_RS03615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7X90_RS03620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7X90_RS03625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7X90_RS03635	COG2096	Adenosyltransferase
H7X90_RS03645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7X90_RS03650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7X90_RS03655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7X90_RS03660	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7X90_RS03680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7X90_RS03690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7X90_RS03700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7X90_RS03705	COG0583	DNA-binding transcription factor activity
H7X90_RS03710	COG3634	alkyl hydroperoxide reductase activity
H7X90_RS03750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7X90_RS03750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7X90_RS03765	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7X90_RS03805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7X90_RS03810	COG1404	Belongs to the peptidase S8 family
H7X90_RS03830	COG1295	ribonuclease BN
H7X90_RS03835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7X90_RS03850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7X90_RS03855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7X90_RS03870	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7X90_RS03880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7X90_RS03885	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7X90_RS03890	COG0193	aminoacyl-tRNA hydrolase activity
H7X90_RS03895	COG0012	GTP binding
H7X90_RS03905	COG2197	response regulator
H7X90_RS03910	COG2205	protein histidine kinase activity
H7X90_RS03910	COG0784	Response regulator, receiver
H7X90_RS03915	COG2200	EAL domain
H7X90_RS03915	COG2199	diguanylate cyclase activity
H7X90_RS03915	COG2203	Gaf domain
H7X90_RS03920	COG0784	Response regulator, receiver
H7X90_RS03920	COG2205	protein histidine kinase activity
H7X90_RS03925	COG4206	TonB-dependent receptor
H7X90_RS03930	COG4242	Belongs to the peptidase S51 family
H7X90_RS03955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7X90_RS03970	COG0250	Participates in transcription elongation, termination and antitermination
H7X90_RS03975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7X90_RS03980	COG0081	regulation of translation
H7X90_RS03985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7X90_RS03990	COG0222	ribosome binding
H7X90_RS03995	COG0085	RNA polymerase activity
H7X90_RS04000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7X90_RS04005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7X90_RS04010	COG0049	tRNA binding
H7X90_RS04015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7X90_RS04020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7X90_RS04025	COG0051	transcription antitermination factor activity, RNA binding
H7X90_RS04030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7X90_RS04035	COG0088	Forms part of the polypeptide exit tunnel
H7X90_RS04040	COG0089	rRNA binding
H7X90_RS04045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7X90_RS04050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7X90_RS04055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7X90_RS04060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7X90_RS04065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7X90_RS04070	COG0255	Belongs to the universal ribosomal protein uL29 family
H7X90_RS04075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7X90_RS04080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7X90_RS04085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7X90_RS04090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7X90_RS04095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7X90_RS04100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7X90_RS04105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7X90_RS04110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7X90_RS04115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7X90_RS04120	COG1841	ribosomal large subunit assembly
H7X90_RS04125	COG0200	Binds to the 23S rRNA
H7X90_RS04130	COG0201	protein transport
H7X90_RS04135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7X90_RS04140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7X90_RS04145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7X90_RS04150	COG0202	RNA polymerase activity
H7X90_RS04155	COG0203	ribosomal protein L17
H7X90_RS04170	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H7X90_RS04180	COG0154	amidase activity
H7X90_RS04195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7X90_RS04200	COG0039	L-malate dehydrogenase activity
H7X90_RS04205	COG0564	pseudouridine synthase activity
H7X90_RS04215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7X90_RS04230	COG0625	glutathione transferase activity
H7X90_RS04240	COG1902	pentaerythritol trinitrate reductase activity
H7X90_RS04240	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7X90_RS04245	COG2364	Membrane
H7X90_RS04250	COG0604	alcohol dehydrogenase
H7X90_RS04265	COG1187	pseudouridine synthase activity
H7X90_RS04285	COG1063	alcohol dehydrogenase
H7X90_RS04295	COG0406	alpha-ribazole phosphatase activity
H7X90_RS04300	COG0285	dihydrofolate synthase activity
H7X90_RS04320	COG2833	Protein of unknown function (DUF455)
H7X90_RS04330	COG3291	Pkd domain containing protein
H7X90_RS04335	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7X90_RS04345	COG0438	transferase activity, transferring glycosyl groups
H7X90_RS04360	COG0248	Ppx GppA phosphatase
H7X90_RS04365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7X90_RS04380	COG4783	chaperone-mediated protein folding
H7X90_RS04395	COG0473	3-isopropylmalate dehydrogenase activity
H7X90_RS04455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7X90_RS04495	COG0592	DNA-directed DNA polymerase activity
H7X90_RS04520	COG2204	response regulator
H7X90_RS04680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7X90_RS04680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7X90_RS04745	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7X90_RS04750	COG0740	serine-type endopeptidase activity
H7X90_RS04755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7X90_RS04795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7X90_RS04800	COG1388	LysM domain
H7X90_RS04800	COG3942	CHAP domain
H7X90_RS04805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7X90_RS04815	COG0328	RNA-DNA hybrid ribonuclease activity
H7X90_RS04820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7X90_RS04825	COG0631	protein serine/threonine phosphatase activity
H7X90_RS04845	COG0859	PFAM glycosyl transferase family 9
H7X90_RS04850	COG3642	lipopolysaccharide core region biosynthetic process
H7X90_RS04855	COG1234	tRNA 3'-trailer cleavage
H7X90_RS04870	COG2076	Multidrug Resistance protein
H7X90_RS04975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7X90_RS04985	COG0537	adenosine 5'-monophosphoramidase activity
H7X90_RS05005	COG0714	Associated with various cellular activities
H7X90_RS05020	COG1399	metal-binding, possibly nucleic acid-binding protein
H7X90_RS05025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7X90_RS05030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7X90_RS05040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7X90_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS05055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7X90_RS05060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7X90_RS05065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7X90_RS05070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7X90_RS05220	COG4774	siderophore transport
H7X90_RS05230	COG2223	nitrite transmembrane transporter activity
H7X90_RS05245	COG2226	methyltransferase
H7X90_RS05255	COG0583	DNA-binding transcription factor activity
H7X90_RS05260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7X90_RS05265	COG0697	spore germination
H7X90_RS05275	COG0477	Major facilitator Superfamily
H7X90_RS05310	COG0583	DNA-binding transcription factor activity
H7X90_RS05320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7X90_RS05335	COG0667	Aldo Keto reductase
H7X90_RS05355	COG0519	Catalyzes the synthesis of GMP from XMP
H7X90_RS05360	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H7X90_RS05365	COG1678	Uncharacterized ACR, COG1678
H7X90_RS05370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7X90_RS05375	COG0540	Belongs to the ATCase OTCase family
H7X90_RS05395	COG2239	Acts as a magnesium transporter
H7X90_RS05400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7X90_RS05415	COG1660	Displays ATPase and GTPase activities
H7X90_RS05420	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H7X90_RS05425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7X90_RS05430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7X90_RS05440	COG1137	ATPase activity
H7X90_RS05455	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7X90_RS05470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7X90_RS05490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7X90_RS05510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7X90_RS05520	COG0628	permease
H7X90_RS05530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7X90_RS05540	COG2261	transglycosylase associated protein
H7X90_RS05550	COG1555	photosystem II stabilization
H7X90_RS05570	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7X90_RS05575	COG1477	protein flavinylation
H7X90_RS05595	COG4771	TonB-dependent receptor
H7X90_RS05605	COG3128	pkhd-type hydroxylase
H7X90_RS05615	COG4774	siderophore transport
H7X90_RS05625	COG2146	nitrite reductase [NAD(P)H] activity
H7X90_RS05640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7X90_RS05645	COG0719	Fe-S assembly protein
H7X90_RS05650	COG0396	ATPase activity
H7X90_RS05660	COG0719	Fe-S assembly protein
H7X90_RS05665	COG1959	2 iron, 2 sulfur cluster binding
H7X90_RS05675	COG0693	protein deglycase activity
H7X90_RS05700	COG1764	response to oxidative stress
H7X90_RS05705	COG0384	phenazine biosynthesis protein PhzF
H7X90_RS05710	COG0384	phenazine biosynthesis protein PhzF
H7X90_RS05715	COG0527	aspartate kinase activity
H7X90_RS05740	COG0142	geranyltranstransferase activity
H7X90_RS05745	COG0366	Alpha amylase catalytic
H7X90_RS05755	COG1082	Xylose isomerase domain protein TIM barrel
H7X90_RS05765	COG2211	Major facilitator Superfamily
H7X90_RS05765	COG2190	(PTS) system
H7X90_RS05800	COG1131	(ABC) transporter
H7X90_RS05810	COG0629	single-stranded DNA binding
H7X90_RS05950	COG4974	Belongs to the 'phage' integrase family
H7X90_RS05995	COG0471	metal ion transport
H7X90_RS05995	COG0490	domain, Protein
H7X90_RS06030	COG2610	gluconate transmembrane transporter activity
H7X90_RS06060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7X90_RS06065	COG0625	glutathione transferase activity
H7X90_RS06070	COG0598	Magnesium transport protein CorA
H7X90_RS06135	COG0673	inositol 2-dehydrogenase activity
H7X90_RS06140	COG2211	Major facilitator Superfamily
H7X90_RS06150	COG1609	Transcriptional regulator
H7X90_RS06190	COG0640	Transcriptional regulator
H7X90_RS06205	COG3655	Transcriptional regulator
H7X90_RS06210	COG1253	flavin adenine dinucleotide binding
H7X90_RS06215	COG1408	metallophosphoesterase
H7X90_RS06220	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H7X90_RS06240	COG2259	Doxx family
H7X90_RS06270	COG0477	Major facilitator Superfamily
H7X90_RS06285	COG1802	Transcriptional regulator
H7X90_RS06320	COG3052	prosthetic group binding
H7X90_RS06335	COG0579	oxidoreductase
H7X90_RS06365	COG3104	oligopeptide transport
H7X90_RS06380	COG1297	OPT oligopeptide transporter protein
H7X90_RS06385	COG1506	peptidase
H7X90_RS06385	COG0823	Involved in the tonB-independent uptake of proteins
H7X90_RS06400	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7X90_RS06405	COG2894	cell division
H7X90_RS06420	COG4585	Histidine kinase
H7X90_RS06425	COG2197	response regulator
H7X90_RS06465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7X90_RS06475	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7X90_RS06485	COG1595	DNA-templated transcription, initiation
H7X90_RS06495	COG1946	Acyl-CoA thioesterase
H7X90_RS06515	COG0824	Thioesterase
H7X90_RS06520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7X90_RS06525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7X90_RS06530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7X90_RS06535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7X90_RS06540	COG0268	Binds directly to 16S ribosomal RNA
H7X90_RS06545	COG0728	peptidoglycan biosynthetic process
H7X90_RS06550	COG0196	riboflavin kinase activity
H7X90_RS06555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7X90_RS06565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7X90_RS06590	COG4206	TonB-dependent receptor
H7X90_RS06610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7X90_RS06655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7X90_RS06660	COG1845	cytochrome c oxidase, subunit III
H7X90_RS06665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7X90_RS06680	COG0326	Molecular chaperone. Has ATPase activity
H7X90_RS06700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7X90_RS06715	COG0228	four-way junction DNA binding
H7X90_RS06720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7X90_RS06725	COG0336	Belongs to the RNA methyltransferase TrmD family
H7X90_RS06730	COG0335	large ribosomal subunit rRNA binding
H7X90_RS06750	COG0534	Mate efflux family protein
H7X90_RS06770	COG0753	catalase activity
H7X90_RS07010	COG0840	transmembrane signaling receptor activity
H7X90_RS07030	COG5001	Diguanylate cyclase
H7X90_RS07030	COG3300	MHYT domain
H7X90_RS07065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H7X90_RS07075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7X90_RS07160	COG2826	transposase and inactivated derivatives, IS30 family
H7X90_RS07220	COG1192	Involved in chromosome partitioning
H7X90_RS07285	COG0666	response to abiotic stimulus
H7X90_RS07295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7X90_RS07345	COG2831	hemolysin activation secretion protein
H7X90_RS07370	COG0840	transmembrane signaling receptor activity
H7X90_RS07390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7X90_RS07410	COG0024	Methionine aminopeptidase
H7X90_RS07435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7X90_RS07450	COG2076	Multidrug Resistance protein
H7X90_RS07460	COG1647	Serine aminopeptidase, S33
H7X90_RS07485	COG2814	Major facilitator Superfamily
H7X90_RS07490	COG3706	GGDEF domain
H7X90_RS07515	COG0588	phosphoglycerate mutase activity
H7X90_RS07520	COG3590	peptidase
H7X90_RS07525	COG2801	Transposase and inactivated derivatives
H7X90_RS07525	COG3415	Transposase
H7X90_RS07535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7X90_RS07545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7X90_RS07550	COG0745	RESPONSE REGULATOR receiver
H7X90_RS07555	COG2205	protein histidine kinase activity
H7X90_RS07560	COG4452	Inner membrane protein CreD
H7X90_RS07575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7X90_RS07580	COG0735	belongs to the Fur family
H7X90_RS07620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7X90_RS07660	COG5002	protein histidine kinase activity
H7X90_RS07660	COG5001	Diguanylate cyclase
H7X90_RS07670	COG1187	pseudouridine synthase activity
H7X90_RS07680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7X90_RS07705	COG1132	(ABC) transporter
H7X90_RS07755	COG1695	Transcriptional regulator
H7X90_RS07775	COG1981	membrane
H7X90_RS07780	COG0825	malonyl-CoA metabolic process
H7X90_RS07805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7X90_RS07815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7X90_RS07820	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7X90_RS07825	COG0750	zinc metalloprotease
H7X90_RS07830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7X90_RS07835	COG0575	Belongs to the CDS family
H7X90_RS07840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7X90_RS07845	COG0233	cytoplasmic translational termination
H7X90_RS07850	COG0528	UMP kinase activity
H7X90_RS07860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7X90_RS07865	COG0052	Belongs to the universal ribosomal protein uS2 family
H7X90_RS07885	COG3188	usher protein
H7X90_RS07905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7X90_RS07915	COG1393	Belongs to the ArsC family
H7X90_RS07920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7X90_RS07925	COG0367	asparagine synthase
H7X90_RS07930	COG0475	glutathione-regulated potassium exporter activity
H7X90_RS07965	COG1566	PFAM secretion protein HlyD family protein
H7X90_RS07970	COG2814	Major facilitator Superfamily
H7X90_RS08005	COG0557	exoribonuclease II activity
H7X90_RS08015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7X90_RS08020	COG1538	Outer membrane efflux protein
H7X90_RS08025	COG1136	(ABC) transporter
H7X90_RS08025	COG0577	efflux transmembrane transporter activity
H7X90_RS08030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7X90_RS08050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7X90_RS08055	COG2259	Doxx family
H7X90_RS08065	COG3220	belongs to the UPF0276 family
H7X90_RS08075	COG0704	Plays a role in the regulation of phosphate uptake
H7X90_RS08085	COG0581	inorganic phosphate transmembrane transporter activity
H7X90_RS08090	COG0573	inorganic phosphate transmembrane transporter activity
H7X90_RS08095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7X90_RS08100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7X90_RS08110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7X90_RS08120	COG1024	Enoyl-CoA hydratase
H7X90_RS08150	COG0116	Belongs to the methyltransferase superfamily
H7X90_RS08150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7X90_RS08170	COG2733	membrane
H7X90_RS08180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7X90_RS08185	COG1012	belongs to the aldehyde dehydrogenase family
H7X90_RS08195	COG0477	Major facilitator Superfamily
H7X90_RS08200	COG2703	oxygen carrier activity
H7X90_RS08220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7X90_RS08225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7X90_RS08230	COG0174	glutamine synthetase
H7X90_RS08240	COG2072	flavoprotein involved in K transport
H7X90_RS08245	COG3842	ATPase activity
H7X90_RS08250	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7X90_RS08255	COG1177	transmembrane transport
H7X90_RS08260	COG1012	belongs to the aldehyde dehydrogenase family
H7X90_RS08275	COG4535	Mg2 and Co2 transporter CorC
H7X90_RS08295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7X90_RS08300	COG1702	phosphate starvation-inducible protein PhoH
H7X90_RS08310	COG1131	(ABC) transporter
H7X90_RS08315	COG0842	Transport permease protein
H7X90_RS08320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7X90_RS08335	COG0741	lytic transglycosylase activity
H7X90_RS08340	COG0723	plastoquinol--plastocyanin reductase activity
H7X90_RS08345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7X90_RS08350	COG2857	Cytochrome c1
H7X90_RS08355	COG0625	glutathione transferase activity
H7X90_RS08360	COG2969	positive regulation of protein catabolic process
H7X90_RS08395	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7X90_RS08405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7X90_RS08420	COG1611	Belongs to the LOG family
H7X90_RS08460	COG4970	Tfp pilus assembly protein FimT
H7X90_RS08465	COG0556	nucleotide-excision repair
H7X90_RS08505	COG3713	MltA-interacting MipA family protein
H7X90_RS08525	COG0811	peptide transport
H7X90_RS08540	COG1663	tetraacyldisaccharide 4'-kinase activity
H7X90_RS08545	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7X90_RS08550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7X90_RS08560	COG0322	excinuclease ABC activity
H7X90_RS08595	COG1136	(ABC) transporter
H7X90_RS08595	COG0577	efflux transmembrane transporter activity
H7X90_RS08680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7X90_RS08705	COG0583	DNA-binding transcription factor activity
H7X90_RS08725	COG4977	sequence-specific DNA binding
H7X90_RS08725	COG1917	Cupin 2, conserved barrel domain protein
H7X90_RS08730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7X90_RS08750	COG0348	domain, Protein
H7X90_RS08765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7X90_RS08780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H7X90_RS08785	COG0069	glutamate synthase activity
H7X90_RS08810	COG1054	Belongs to the UPF0176 family
H7X90_RS08815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7X90_RS08830	COG1253	flavin adenine dinucleotide binding
H7X90_RS08850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7X90_RS08865	COG0504	CTP synthase activity
H7X90_RS08870	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7X90_RS08885	COG0148	phosphopyruvate hydratase activity
H7X90_RS08890	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7X90_RS08895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7X90_RS08900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7X90_RS08910	COG2840	Smr protein MutS2
H7X90_RS08915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7X90_RS08920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7X90_RS08945	COG1534	Rna-binding protein
H7X90_RS08950	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7X90_RS08955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7X90_RS08965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7X90_RS08970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7X90_RS08975	COG1923	regulation of RNA biosynthetic process
H7X90_RS08980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7X90_RS08985	COG1546	Belongs to the CinA family
H7X90_RS08990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7X90_RS08995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7X90_RS09000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7X90_RS09005	COG2137	regulation of response to DNA damage stimulus
H7X90_RS09010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7X90_RS09015	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7X90_RS09065	COG3540	Alkaline phosphatase
H7X90_RS09080	COG3258	Cytochrome c
H7X90_RS09095	COG2223	nitrite transmembrane transporter activity
H7X90_RS09110	COG1741	Belongs to the pirin family
H7X90_RS09140	COG0352	thiamine-phosphate diphosphorylase activity
H7X90_RS09140	COG0351	phosphomethylpyrimidine kinase
H7X90_RS09155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7X90_RS09160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7X90_RS09170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7X90_RS09180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7X90_RS09185	COG0477	Major facilitator Superfamily
H7X90_RS09195	COG0617	tRNA 3'-terminal CCA addition
H7X90_RS09200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7X90_RS09205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7X90_RS09210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7X90_RS09220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H7X90_RS09225	COG0166	Belongs to the GPI family
H7X90_RS09230	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H7X90_RS09240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7X90_RS09245	COG0671	phosphoesterase, PA-phosphatase related
H7X90_RS09255	COG0800	Aldolase
H7X90_RS09260	COG0129	dihydroxy-acid dehydratase activity
H7X90_RS09270	COG0837	glucose binding
H7X90_RS09295	COG2009	succinate dehydrogenase
H7X90_RS09300	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7X90_RS09305	COG1053	succinate dehydrogenase
H7X90_RS09325	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7X90_RS09340	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7X90_RS09350	COG0552	protein localization to endoplasmic reticulum
H7X90_RS09365	COG0742	ribosomal rna small subunit methyltransferase
H7X90_RS09370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7X90_RS09380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7X90_RS09385	COG0405	Gamma-glutamyltransferase
H7X90_RS09390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7X90_RS09410	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7X90_RS09430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7X90_RS09440	COG0415	Belongs to the DNA photolyase family
H7X90_RS09445	COG2885	chlorophyll binding
H7X90_RS09450	COG0583	DNA-binding transcription factor activity
H7X90_RS09545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7X90_RS09555	COG2914	Belongs to the UPF0125 (RnfH) family
H7X90_RS09560	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7X90_RS09565	COG0735	belongs to the Fur family
H7X90_RS09575	COG0583	DNA-binding transcription factor activity
H7X90_RS09580	COG0497	DNA recombination
H7X90_RS09585	COG1420	regulation of RNA biosynthetic process
H7X90_RS09590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7X90_RS09595	COG0443	Heat shock 70 kDa protein
H7X90_RS09600	COG0484	heat shock protein binding
H7X90_RS09605	COG2207	Transcriptional regulator
H7X90_RS09610	COG2223	nitrite transmembrane transporter activity
H7X90_RS09615	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7X90_RS09620	COG1605	Chorismate mutase
H7X90_RS09620	COG0287	Prephenate dehydrogenase
H7X90_RS09630	COG1132	(ABC) transporter
H7X90_RS09650	COG5001	Diguanylate cyclase
H7X90_RS09660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7X90_RS09665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7X90_RS09670	COG0343	queuine tRNA-ribosyltransferase activity
H7X90_RS09675	COG1862	Preprotein translocase
H7X90_RS09685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7X90_RS09690	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7X90_RS09700	COG2081	HI0933 family
H7X90_RS09705	COG4681	YaeQ
H7X90_RS09710	COG0564	pseudouridine synthase activity
H7X90_RS09725	COG0625	glutathione transferase activity
H7X90_RS09730	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7X90_RS09735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7X90_RS09740	COG0513	Belongs to the DEAD box helicase family
H7X90_RS09750	COG0583	DNA-binding transcription factor activity
H7X90_RS09755	COG0488	(ABC) transporter
H7X90_RS09780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7X90_RS09795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7X90_RS09800	COG2957	Belongs to the agmatine deiminase family
H7X90_RS09810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7X90_RS09815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7X90_RS09825	COG0776	regulation of translation
H7X90_RS09835	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7X90_RS09840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7X90_RS09850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7X90_RS09855	COG0183	Belongs to the thiolase family
H7X90_RS09860	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7X90_RS09860	COG1024	Enoyl-CoA hydratase
H7X90_RS09870	COG0105	UTP biosynthetic process
H7X90_RS09875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7X90_RS09880	COG0859	PFAM glycosyl transferase family 9
H7X90_RS09880	COG0457	Tetratricopeptide repeat
H7X90_RS09885	COG1426	Protein conserved in bacteria
H7X90_RS09885	COG1426	Protein conserved in bacteria
H7X90_RS09895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7X90_RS09900	COG1160	GTP binding
H7X90_RS09920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7X90_RS09925	COG0475	glutathione-regulated potassium exporter activity
H7X90_RS09925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7X90_RS09940	COG0519	Catalyzes the synthesis of GMP from XMP
H7X90_RS09940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7X90_RS09980	COG0583	DNA-binding transcription factor activity
H7X90_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS10005	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS10035	COG0640	Transcriptional regulator
H7X90_RS10050	COG4716	Myosin-crossreactive antigen
H7X90_RS10085	COG0431	NADPH-dependent FMN reductase
H7X90_RS10095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7X90_RS10100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7X90_RS10105	COG1473	amidohydrolase
H7X90_RS10115	COG1126	abc transporter atp-binding protein
H7X90_RS10120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7X90_RS10145	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H7X90_RS10150	COG0583	DNA-binding transcription factor activity
H7X90_RS10155	COG0477	Major facilitator Superfamily
H7X90_RS10160	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS10170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7X90_RS10190	COG1309	transcriptional regulator
H7X90_RS10205	COG0697	spore germination
H7X90_RS10210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7X90_RS10215	COG0167	dihydroorotate dehydrogenase activity
H7X90_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS10235	COG1012	belongs to the aldehyde dehydrogenase family
H7X90_RS10280	COG4191	Histidine kinase
H7X90_RS10280	COG0784	Response regulator, receiver
H7X90_RS10285	COG3850	Histidine kinase
H7X90_RS10285	COG4999	Histidine kinase
H7X90_RS10285	COG3437	response regulator, receiver
H7X90_RS10285	COG2205	protein histidine kinase activity
H7X90_RS10290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7X90_RS10300	COG0745	RESPONSE REGULATOR receiver
H7X90_RS10305	COG0640	Transcriptional regulator
H7X90_RS10345	COG0460	homoserine dehydrogenase
H7X90_RS10345	COG0527	aspartate kinase activity
H7X90_RS10355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7X90_RS10360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7X90_RS10365	COG0124	histidyl-tRNA synthetase
H7X90_RS10375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7X90_RS10380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7X90_RS10385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7X90_RS10390	COG0131	Imidazoleglycerol-phosphate dehydratase
H7X90_RS10390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7X90_RS10395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7X90_RS10400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7X90_RS10405	COG0107	imidazoleglycerol-phosphate synthase activity
H7X90_RS10410	COG0140	phosphoribosyl-ATP diphosphatase activity
H7X90_RS10410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7X90_RS10430	COG1446	asparaginase
H7X90_RS10435	COG3142	Participates in the control of copper homeostasis
H7X90_RS10455	COG0789	Transcriptional regulator
H7X90_RS10470	COG3537	Alpha-1,2-mannosidase
H7X90_RS10475	COG1609	Transcriptional regulator
H7X90_RS10485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7X90_RS10500	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H7X90_RS10505	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H7X90_RS10510	COG0235	Class ii aldolase
H7X90_RS10525	COG0531	amino acid
H7X90_RS10530	COG0531	amino acid
H7X90_RS10540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7X90_RS10545	COG0277	FAD linked oxidase domain protein
H7X90_RS10560	COG2205	protein histidine kinase activity
H7X90_RS10565	COG0745	RESPONSE REGULATOR receiver
H7X90_RS10570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7X90_RS10575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7X90_RS10590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7X90_RS10635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7X90_RS10650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7X90_RS10655	COG0505	Belongs to the CarA family
H7X90_RS10660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7X90_RS10665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7X90_RS10680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7X90_RS10685	COG4676	Protein conserved in bacteria
H7X90_RS10695	COG3279	Response regulator of the LytR AlgR family
H7X90_RS10710	COG1012	belongs to the aldehyde dehydrogenase family
H7X90_RS10735	COG2205	protein histidine kinase activity
H7X90_RS10735	COG2198	Histidine kinase
H7X90_RS10735	COG0784	Response regulator, receiver
H7X90_RS10740	COG1024	Enoyl-CoA hydratase
H7X90_RS10745	COG0318	PFAM AMP-dependent synthetase and ligase
H7X90_RS10750	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7X90_RS10755	COG1012	belongs to the aldehyde dehydrogenase family
H7X90_RS10760	COG1309	transcriptional regulator
H7X90_RS10765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7X90_RS10770	COG2801	Transposase and inactivated derivatives
H7X90_RS10770	COG3415	Transposase
H7X90_RS10815	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H7X90_RS10825	COG0840	transmembrane signaling receptor activity
H7X90_RS10835	COG0840	transmembrane signaling receptor activity
H7X90_RS10845	COG0835	chemotaxis
H7X90_RS10850	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H7X90_RS10855	COG0840	transmembrane signaling receptor activity
H7X90_RS10865	COG0745	RESPONSE REGULATOR receiver
H7X90_RS10875	COG0835	chemotaxis
H7X90_RS10885	COG1360	Flagellar Motor Protein
H7X90_RS10890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7X90_RS10895	COG2198	Histidine kinase
H7X90_RS10895	COG0784	Response regulator, receiver
H7X90_RS10895	COG0643	Histidine kinase
H7X90_RS10900	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7X90_RS10925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7X90_RS10930	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7X90_RS10950	COG1987	bacterial-type flagellum assembly
H7X90_RS10960	COG3190	flagellar
H7X90_RS11010	COG1677	Flagellar hook-basal body complex protein FliE
H7X90_RS11030	COG2197	response regulator
H7X90_RS11050	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7X90_RS11060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7X90_RS11090	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7X90_RS11100	COG4787	bacterial-type flagellum-dependent cell motility
H7X90_RS11115	COG1558	bacterial-type flagellum-dependent cell motility
H7X90_RS11120	COG1815	bacterial-type flagellum-dependent cell motility
H7X90_RS11125	COG0835	chemotaxis
H7X90_RS11125	COG0784	Response regulator, receiver
H7X90_RS11145	COG5002	protein histidine kinase activity
H7X90_RS11180	COG2915	High frequency lysogenization protein hflD homolog
H7X90_RS11185	COG0482	sulfurtransferase activity
H7X90_RS11200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7X90_RS11210	COG0542	response to heat
H7X90_RS11240	COG0492	ferredoxin-NADP+ reductase activity
H7X90_RS11245	COG1674	ftsk spoiiie
H7X90_RS11260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7X90_RS11270	COG2819	hydrolase of the alpha beta superfamily
H7X90_RS11280	COG4558	Periplasmic binding protein
H7X90_RS11285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7X90_RS11290	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H7X90_RS11300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7X90_RS11315	COG0784	Response regulator, receiver
H7X90_RS11315	COG5002	protein histidine kinase activity
H7X90_RS11345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7X90_RS11355	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H7X90_RS11370	COG1595	DNA-templated transcription, initiation
H7X90_RS11390	COG0784	Response regulator, receiver
H7X90_RS11395	COG4251	negative regulation of phosphorylation
H7X90_RS11405	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H7X90_RS11415	COG0456	acetyltransferase
H7X90_RS11415	COG0454	-acetyltransferase
H7X90_RS11420	COG2205	protein histidine kinase activity
H7X90_RS11500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7X90_RS11505	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7X90_RS11510	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7X90_RS11515	COG2080	2 iron, 2 sulfur cluster binding
H7X90_RS11525	COG1764	response to oxidative stress
H7X90_RS11535	COG0583	DNA-binding transcription factor activity
H7X90_RS11555	COG1595	DNA-templated transcription, initiation
H7X90_RS11560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7X90_RS11645	COG3685	Protein conserved in bacteria
H7X90_RS11670	COG3546	catalase activity
H7X90_RS11675	COG3685	Protein conserved in bacteria
H7X90_RS11700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7X90_RS11720	COG1063	alcohol dehydrogenase
H7X90_RS11750	COG1609	Transcriptional regulator
H7X90_RS11755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7X90_RS11755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7X90_RS11760	COG1105	Belongs to the carbohydrate kinase PfkB family
H7X90_RS11765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7X90_RS11765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7X90_RS11780	COG1733	regulation of RNA biosynthetic process
H7X90_RS11785	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7X90_RS11800	COG4771	TonB-dependent receptor
H7X90_RS11805	COG0738	Major facilitator superfamily
H7X90_RS11810	COG1609	Transcriptional regulator
H7X90_RS11815	COG1472	Belongs to the glycosyl hydrolase 3 family
H7X90_RS11830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7X90_RS11845	COG2828	Protein conserved in bacteria
H7X90_RS11850	COG0583	DNA-binding transcription factor activity
H7X90_RS11875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7X90_RS11880	COG0583	DNA-binding transcription factor activity
H7X90_RS11910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7X90_RS11935	COG2205	protein histidine kinase activity
H7X90_RS11945	COG0318	PFAM AMP-dependent synthetase and ligase
H7X90_RS11960	COG2186	Transcriptional regulator
H7X90_RS11980	COG2271	Major facilitator Superfamily
H7X90_RS11985	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS11995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7X90_RS12025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7X90_RS12045	COG0583	DNA-binding transcription factor activity
H7X90_RS12070	COG2204	response regulator
H7X90_RS12150	COG0708	Exodeoxyribonuclease III
H7X90_RS12155	COG0366	Alpha amylase catalytic
H7X90_RS12160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7X90_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS12180	COG0577	efflux transmembrane transporter activity
H7X90_RS12180	COG1136	(ABC) transporter
H7X90_RS12185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7X90_RS12195	COG0745	RESPONSE REGULATOR receiver
H7X90_RS12200	COG2205	protein histidine kinase activity
H7X90_RS12210	COG3214	Protein conserved in bacteria
H7X90_RS12220	COG4774	siderophore transport
H7X90_RS12240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7X90_RS12245	COG1285	pathogenesis
H7X90_RS12250	COG4191	Histidine kinase
H7X90_RS12255	COG4566	intracellular signal transduction
H7X90_RS12315	COG0243	molybdopterin cofactor binding
H7X90_RS12335	COG3415	Transposase
H7X90_RS12335	COG2801	Transposase and inactivated derivatives
H7X90_RS12345	COG0477	Major facilitator Superfamily
H7X90_RS12370	COG1136	(ABC) transporter
H7X90_RS12385	COG0583	DNA-binding transcription factor activity
H7X90_RS12390	COG0656	L-ascorbic acid biosynthetic process
H7X90_RS12410	COG0583	DNA-binding transcription factor activity
H7X90_RS12415	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS12445	COG3537	Alpha-1,2-mannosidase
H7X90_RS12460	COG0477	Major facilitator Superfamily
H7X90_RS12480	COG2202	Pas domain
H7X90_RS12480	COG3920	Histidine kinase
H7X90_RS12525	COG1335	isochorismatase
H7X90_RS12530	COG1335	isochorismatase
H7X90_RS12560	COG0811	peptide transport
H7X90_RS12705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7X90_RS12710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7X90_RS12720	COG0840	transmembrane signaling receptor activity
H7X90_RS12725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7X90_RS12730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7X90_RS12735	COG4149	molybdate abc transporter
H7X90_RS12740	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7X90_RS12745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7X90_RS12760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7X90_RS12765	COG2181	nitrate reductase activity
H7X90_RS12770	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H7X90_RS12775	COG1140	nitrate reductase beta subunit
H7X90_RS12780	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H7X90_RS12785	COG2223	nitrite transmembrane transporter activity
H7X90_RS12795	COG0746	molybdenum cofactor guanylyltransferase activity
H7X90_RS12800	COG0314	molybdopterin synthase activity
H7X90_RS12810	COG0303	'Molybdopterin
H7X90_RS12815	COG0315	cyclic pyranopterin monophosphate synthase activity
H7X90_RS12815	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7X90_RS12820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7X90_RS12875	COG2207	Transcriptional regulator
H7X90_RS12915	COG2205	protein histidine kinase activity
H7X90_RS12925	COG2194	sulfuric ester hydrolase activity
H7X90_RS12945	COG2885	chlorophyll binding
H7X90_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS12965	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H7X90_RS12965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7X90_RS12970	COG1535	isochorismatase
H7X90_RS12970	COG3433	isochorismatase activity
H7X90_RS12975	COG3433	isochorismatase activity
H7X90_RS12975	COG1535	isochorismatase
H7X90_RS12980	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7X90_RS12985	COG1169	isochorismate synthase
H7X90_RS12995	COG2409	Drug exporters of the RND superfamily
H7X90_RS13000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7X90_RS13070	COG1914	H( )-stimulated, divalent metal cation uptake system
H7X90_RS13085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7X90_RS13090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7X90_RS13095	COG3321	synthase
H7X90_RS13095	COG0604	alcohol dehydrogenase
H7X90_RS13095	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS13105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7X90_RS13150	COG4772	TonB-dependent receptor
H7X90_RS13170	COG2226	methyltransferase
H7X90_RS13215	COG4964	Belongs to the GSP D family
H7X90_RS13270	COG2814	Major facilitator Superfamily
H7X90_RS13280	COG1228	amidohydrolase
H7X90_RS13290	COG1335	isochorismatase
H7X90_RS13305	COG3850	Histidine kinase
H7X90_RS13310	COG2197	response regulator
H7X90_RS13315	COG2814	Major facilitator Superfamily
H7X90_RS13325	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7X90_RS13335	COG0583	DNA-binding transcription factor activity
H7X90_RS13350	COG3161	chorismate lyase activity
H7X90_RS13390	COG0277	FAD linked oxidase domain protein
H7X90_RS13395	COG1304	FMN binding
H7X90_RS13400	COG2186	Transcriptional regulator
H7X90_RS13410	COG1285	pathogenesis
H7X90_RS13435	COG2814	Major facilitator Superfamily
H7X90_RS13490	COG0587	DNA-directed DNA polymerase activity
H7X90_RS13505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7X90_RS13510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7X90_RS13510	COG0519	Catalyzes the synthesis of GMP from XMP
H7X90_RS13525	COG1595	DNA-templated transcription, initiation
H7X90_RS13535	COG4206	TonB-dependent receptor
H7X90_RS13535	COG1629	transport
H7X90_RS13565	COG0531	amino acid
H7X90_RS13580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7X90_RS13590	COG0789	Transcriptional regulator
H7X90_RS13670	COG5002	protein histidine kinase activity
H7X90_RS13670	COG3447	MASE1 domain protein
H7X90_RS13670	COG5001	Diguanylate cyclase
H7X90_RS13675	COG2183	response to ionizing radiation
H7X90_RS13690	COG1983	PspC domain protein
H7X90_RS13700	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7X90_RS13715	COG0534	Mate efflux family protein
H7X90_RS13735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7X90_RS13745	COG0668	transmembrane transport
H7X90_RS13750	COG1902	pentaerythritol trinitrate reductase activity
H7X90_RS13760	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7X90_RS13770	COG1733	regulation of RNA biosynthetic process
H7X90_RS13775	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7X90_RS13855	COG3702	type iv secretory pathway
H7X90_RS13875	COG2948	multi-organism process
H7X90_RS13885	COG3736	Type IV secretory pathway, component VirB8
H7X90_RS13895	COG3505	Type IV secretory pathway VirD4
H7X90_RS13910	COG2814	Major facilitator Superfamily
H7X90_RS13915	COG0789	Transcriptional regulator
H7X90_RS13950	COG0784	Response regulator, receiver
H7X90_RS13950	COG4191	Histidine kinase
H7X90_RS13965	COG4774	siderophore transport
H7X90_RS13985	COG1733	regulation of RNA biosynthetic process
H7X90_RS13990	COG0604	alcohol dehydrogenase
H7X90_RS14000	COG0210	DNA helicase
H7X90_RS14010	COG3209	COG3209 Rhs family protein
H7X90_RS14030	COG0583	DNA-binding transcription factor activity
H7X90_RS14035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7X90_RS14045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7X90_RS14060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7X90_RS14065	COG1605	Chorismate mutase
H7X90_RS14065	COG0077	Prephenate dehydratase
H7X90_RS14070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7X90_RS14115	COG1228	amidohydrolase
H7X90_RS14130	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7X90_RS14180	COG2957	Belongs to the agmatine deiminase family
H7X90_RS14185	COG0583	DNA-binding transcription factor activity
H7X90_RS14230	COG3415	Transposase
H7X90_RS14230	COG2801	Transposase and inactivated derivatives
H7X90_RS14240	COG4993	Dehydrogenase
H7X90_RS14250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7X90_RS14260	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H7X90_RS14270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7X90_RS14275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7X90_RS14290	COG0359	binds to the 23S rRNA
H7X90_RS14295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7X90_RS14300	COG0360	Binds together with S18 to 16S ribosomal RNA
H7X90_RS14310	COG0316	Belongs to the HesB IscA family
H7X90_RS14315	COG0017	Asparaginyl-tRNA synthetase
H7X90_RS14335	COG0288	reversible hydration of carbon dioxide
H7X90_RS14345	COG3844	kynureninase activity
H7X90_RS14350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7X90_RS14355	COG2925	Exonuclease
H7X90_RS14380	COG2902	Dehydrogenase
H7X90_RS14390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7X90_RS14395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7X90_RS14410	COG1960	acyl-CoA dehydrogenase activity
H7X90_RS14415	COG2226	methyltransferase
H7X90_RS14425	COG1410	methionine synthase
H7X90_RS14425	COG0646	methionine synthase
H7X90_RS14440	COG2900	Belongs to the SlyX family
H7X90_RS14455	COG0386	Belongs to the glutathione peroxidase family
H7X90_RS14465	COG1725	Transcriptional regulator
H7X90_RS14470	COG1131	(ABC) transporter
H7X90_RS14495	COG0114	fumarate hydratase activity
H7X90_RS14505	COG2850	peptidyl-arginine hydroxylation
H7X90_RS14515	COG0567	Dehydrogenase, E1 component
H7X90_RS14540	COG3540	Alkaline phosphatase
H7X90_RS14550	COG0305	Participates in initiation and elongation during chromosome replication
H7X90_RS14570	COG0625	glutathione transferase activity
H7X90_RS14590	COG0084	hydrolase, TatD family'
H7X90_RS14595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7X90_RS14630	COG0625	glutathione transferase activity
H7X90_RS14645	COG1595	DNA-templated transcription, initiation
H7X90_RS14650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7X90_RS14665	COG0386	Belongs to the glutathione peroxidase family
H7X90_RS14670	COG0339	signal peptide processing
H7X90_RS14680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7X90_RS14700	COG0705	Rhomboid family
H7X90_RS14705	COG3104	oligopeptide transport
H7X90_RS14715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7X90_RS14720	COG4290	ribonuclease
H7X90_RS14735	COG0316	Belongs to the HesB IscA family
H7X90_RS14735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7X90_RS14740	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7X90_RS14750	COG0428	transporter
H7X90_RS14760	COG1530	ribonuclease E activity
H7X90_RS14775	COG0395	ABC-type sugar transport system, permease component
H7X90_RS14805	COG0271	Belongs to the BolA IbaG family
H7X90_RS14810	COG2350	Protein conserved in bacteria
H7X90_RS14815	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7X90_RS14820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7X90_RS14825	COG1187	pseudouridine synthase activity
H7X90_RS14835	COG2814	Major facilitator Superfamily
H7X90_RS14855	COG0436	Aminotransferase
H7X90_RS14860	COG4133	protoheme IX ABC transporter activity
H7X90_RS14880	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7X90_RS14895	COG4235	cytochrome complex assembly
H7X90_RS14895	COG3088	subunit of a heme lyase
H7X90_RS14905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7X90_RS14915	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7X90_RS14920	COG4988	ABC transporter
H7X90_RS14930	COG1294	oxidase, subunit
H7X90_RS14960	COG0726	polysaccharide deacetylase
H7X90_RS14960	COG1649	PFAM Uncharacterised BCR, COG1649
H7X90_RS14965	COG1215	transferase activity, transferring glycosyl groups
H7X90_RS14975	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7X90_RS14990	COG0165	Argininosuccinate lyase
H7X90_RS14995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7X90_RS15005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7X90_RS15010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7X90_RS15015	COG0137	argininosuccinate synthase activity
H7X90_RS15020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7X90_RS15035	COG2166	iron-sulfur cluster assembly
H7X90_RS15055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7X90_RS15075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7X90_RS15080	COG0402	S-adenosylhomocysteine deaminase activity
H7X90_RS15085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7X90_RS15090	COG1509	lysine 2,3-aminomutase activity
H7X90_RS15095	COG5001	Diguanylate cyclase
H7X90_RS15095	COG3300	MHYT domain
H7X90_RS15115	COG0501	Belongs to the peptidase M48B family
H7X90_RS15125	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS15145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7X90_RS15150	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7X90_RS15155	COG0802	atpase or kinase
H7X90_RS15160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7X90_RS15160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7X90_RS15165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7X90_RS15170	COG1570	exodeoxyribonuclease VII activity
H7X90_RS15185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7X90_RS15205	COG4771	TonB-dependent receptor
H7X90_RS15210	COG1309	transcriptional regulator
H7X90_RS15245	COG2169	Transcriptional regulator
H7X90_RS15245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7X90_RS15250	COG2130	NADP-dependent
H7X90_RS15275	COG1960	acyl-CoA dehydrogenase activity
H7X90_RS15285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7X90_RS15315	COG1309	transcriptional regulator
H7X90_RS15320	COG2076	Multidrug Resistance protein
H7X90_RS15325	COG5487	UPF0391 membrane protein
H7X90_RS15330	COG1280	lysine exporter protein (LysE YggA)
H7X90_RS15335	COG1794	racemase activity, acting on amino acids and derivatives
H7X90_RS15370	COG0776	regulation of translation
H7X90_RS15375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7X90_RS15375	COG0072	phenylalanine-tRNA ligase activity
H7X90_RS15380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7X90_RS15385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7X90_RS15390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7X90_RS15395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7X90_RS15400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7X90_RS15435	COG1185	polyribonucleotide nucleotidyltransferase activity
H7X90_RS15440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7X90_RS15450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7X90_RS15455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7X90_RS15460	COG0195	Participates in both transcription termination and antitermination
H7X90_RS15465	COG0779	Required for maturation of 30S ribosomal subunits
H7X90_RS15480	COG1007	ATP synthesis coupled electron transport
H7X90_RS15495	COG0713	ATP synthesis coupled electron transport
H7X90_RS15505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7X90_RS15510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7X90_RS15525	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H7X90_RS15530	COG0649	NAD binding
H7X90_RS15535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7X90_RS15540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7X90_RS15545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7X90_RS15560	COG0149	triose-phosphate isomerase activity
H7X90_RS15570	COG3083	sulfuric ester hydrolase activity
H7X90_RS15575	COG0438	transferase activity, transferring glycosyl groups
H7X90_RS15580	COG0726	polysaccharide deacetylase
H7X90_RS15585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7X90_RS15590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7X90_RS15595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7X90_RS15600	COG0159	tryptophan synthase activity
H7X90_RS15610	COG0133	tryptophan synthase activity
H7X90_RS15630	COG0135	phosphoribosylanthranilate isomerase activity
H7X90_RS15635	COG0101	tRNA pseudouridine synthase activity
H7X90_RS15650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7X90_RS15660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7X90_RS15665	COG2890	protein-(glutamine-N5) methyltransferase activity
H7X90_RS15670	COG1999	signal sequence binding
H7X90_RS15675	COG0688	phosphatidylethanolamine metabolic process
H7X90_RS15690	COG0433	COG0433 Predicted ATPase
H7X90_RS15695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7X90_RS15705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7X90_RS15710	COG0412	Dienelactone hydrolase
H7X90_RS15725	COG0717	Belongs to the dCTP deaminase family
H7X90_RS15730	COG0489	protein tyrosine kinase activity
H7X90_RS15735	COG4771	TonB-dependent receptor
H7X90_RS15740	COG4771	TonB-dependent receptor
H7X90_RS15750	COG3590	peptidase
H7X90_RS15785	COG0697	spore germination
H7X90_RS15795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7X90_RS15800	COG2311	Membrane
H7X90_RS15805	COG1047	Peptidyl-prolyl cis-trans
H7X90_RS15810	COG0791	NLP P60 protein
H7X90_RS15815	COG0791	NLP P60 protein
H7X90_RS15820	COG1301	dicarboxylic acid transport
H7X90_RS15840	COG1722	exodeoxyribonuclease VII activity
H7X90_RS15845	COG0142	geranyltranstransferase activity
H7X90_RS15855	COG0312	modulator of DNA gyrase
H7X90_RS15860	COG3028	Belongs to the UPF0307 family
H7X90_RS15865	COG0312	modulator of DNA gyrase
H7X90_RS15885	COG2968	Membrane
H7X90_RS15910	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7X90_RS15920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7X90_RS15935	COG0495	leucyl-tRNA aminoacylation
H7X90_RS15945	COG3118	belongs to the thioredoxin family
H7X90_RS15955	COG2203	Gaf domain
H7X90_RS15955	COG5001	Diguanylate cyclase
H7X90_RS15955	COG4251	negative regulation of phosphorylation
H7X90_RS15955	COG3706	GGDEF domain
H7X90_RS15975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7X90_RS15985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7X90_RS15990	COG0346	lactoylglutathione lyase activity
H7X90_RS16000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7X90_RS16000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7X90_RS16010	COG2878	Part of a membrane complex involved in electron transport
H7X90_RS16015	COG0251	oxidation-reduction process
H7X90_RS16020	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7X90_RS16020	COG0392	lysyltransferase activity
H7X90_RS16050	COG2824	Alkylphosphonate utilization operon protein PhnA
H7X90_RS16055	COG0443	Heat shock 70 kDa protein
H7X90_RS16095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7X90_RS16100	COG3122	Protein conserved in bacteria
H7X90_RS16105	COG1451	nucleotide metabolic process
H7X90_RS16115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7X90_RS16135	COG0183	Belongs to the thiolase family
H7X90_RS16150	COG1960	acyl-CoA dehydrogenase activity
H7X90_RS16160	COG1793	dna ligase
H7X90_RS16165	COG1201	RNA secondary structure unwinding
H7X90_RS16180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7X90_RS16185	COG1278	Cold shock
H7X90_RS16190	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7X90_RS16195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7X90_RS16200	COG1472	Belongs to the glycosyl hydrolase 3 family
H7X90_RS16205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7X90_RS16210	COG2954	triphosphatase activity
H7X90_RS16215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7X90_RS16220	COG0745	RESPONSE REGULATOR receiver
H7X90_RS16225	COG1381	Involved in DNA repair and RecF pathway recombination
H7X90_RS16230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7X90_RS16245	COG0681	Belongs to the peptidase S26 family
H7X90_RS16250	COG0481	GTPase activity
H7X90_RS16255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7X90_RS16270	COG1024	Enoyl-CoA hydratase
H7X90_RS16270	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7X90_RS16275	COG1741	Belongs to the pirin family
H7X90_RS16280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7X90_RS16290	COG1741	Belongs to the pirin family
H7X90_RS16295	COG1966	Carbon starvation protein
H7X90_RS16300	COG2879	small protein
H7X90_RS16315	COG2205	protein histidine kinase activity
H7X90_RS16355	COG2814	Major facilitator Superfamily
H7X90_RS16360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7X90_RS16360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7X90_RS16370	COG1113	amino acid transport
H7X90_RS16375	COG1917	Cupin 2, conserved barrel domain protein
H7X90_RS16375	COG2207	Transcriptional regulator
H7X90_RS16380	COG0753	catalase activity
H7X90_RS16410	COG1376	ErfK ybiS ycfS ynhG family protein
H7X90_RS16415	COG0739	heme binding
H7X90_RS16425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7X90_RS16435	COG0330	HflC and HflK could
H7X90_RS16440	COG0330	HflC and HflK could
H7X90_RS16445	COG0604	alcohol dehydrogenase
H7X90_RS16460	COG0678	peroxiredoxin activity
H7X90_RS16470	COG4953	penicillin-binding protein 1C
H7X90_RS16475	COG2373	Large extracellular alpha-helical protein
H7X90_RS16480	COG2079	MmgE PrpD family protein
H7X90_RS16485	COG2828	Protein conserved in bacteria
H7X90_RS16495	COG3609	addiction module antidote protein, CC2985 family
H7X90_RS16525	COG0259	pyridoxamine-phosphate oxidase activity
H7X90_RS16540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7X90_RS16560	COG0477	Major facilitator Superfamily
H7X90_RS16570	COG5002	protein histidine kinase activity
H7X90_RS16570	COG0784	Response regulator, receiver
H7X90_RS16570	COG2198	Histidine kinase
H7X90_RS16585	COG3038	cytochrome b561
H7X90_RS16600	COG1760	l-serine dehydratase
H7X90_RS16605	COG2267	carboxylic ester hydrolase activity
H7X90_RS16610	COG0460	homoserine dehydrogenase
H7X90_RS16610	COG0527	aspartate kinase activity
H7X90_RS16615	COG0626	cystathionine gamma-synthase activity
H7X90_RS16620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7X90_RS16625	COG0739	heme binding
H7X90_RS16630	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H7X90_RS16635	COG1272	protein, Hemolysin III
H7X90_RS16655	COG0463	Glycosyl transferase, family 2
H7X90_RS16660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7X90_RS16665	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7X90_RS16680	COG1309	transcriptional regulator
H7X90_RS16690	COG1960	acyl-CoA dehydrogenase activity
H7X90_RS16720	COG0583	DNA-binding transcription factor activity
H7X90_RS16730	COG0509	glycine decarboxylation via glycine cleavage system
H7X90_RS16735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7X90_RS16745	COG0330	HflC and HflK could
H7X90_RS16755	COG1742	UPF0060 membrane protein
H7X90_RS16760	COG3956	TIGRFAM MazG family protein
H7X90_RS16770	COG0494	nUDIX hydrolase
H7X90_RS16780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7X90_RS16795	COG2198	Histidine kinase
H7X90_RS16795	COG0784	Response regulator, receiver
H7X90_RS16795	COG0643	Histidine kinase
H7X90_RS16800	COG0840	transmembrane signaling receptor activity
H7X90_RS16805	COG0835	chemotaxis
H7X90_RS16820	COG0189	ligase activity
H7X90_RS16835	COG1199	ATP-dependent helicase activity
H7X90_RS16845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7X90_RS16850	COG1215	transferase activity, transferring glycosyl groups
H7X90_RS16865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7X90_RS16875	COG1643	Atp-dependent helicase
H7X90_RS16880	COG0783	Belongs to the Dps family
H7X90_RS16885	COG0514	ATP-dependent DNA helicase (RecQ)
H7X90_RS16950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7X90_RS16955	COG0602	queuosine metabolic process
H7X90_RS16965	COG2885	chlorophyll binding
H7X90_RS16985	COG0811	peptide transport
H7X90_RS16990	COG0824	Thioesterase
H7X90_RS16995	COG2255	four-way junction helicase activity
H7X90_RS17005	COG0632	four-way junction helicase activity
H7X90_RS17010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7X90_RS17015	COG0217	transcriptional regulatory protein
H7X90_RS17035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7X90_RS17065	COG0488	(ABC) transporter
H7X90_RS17090	COG4651	solute:proton antiporter activity
H7X90_RS17090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7X90_RS17100	COG0745	RESPONSE REGULATOR receiver
H7X90_RS17105	COG2205	protein histidine kinase activity
H7X90_RS17115	COG0542	response to heat
H7X90_RS17135	COG0028	Belongs to the TPP enzyme family
H7X90_RS17160	COG3387	PFAM Glycoside hydrolase 15-related
H7X90_RS17165	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H7X90_RS17170	COG3011	Protein conserved in bacteria
H7X90_RS17185	COG0564	pseudouridine synthase activity
H7X90_RS17190	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7X90_RS17205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7X90_RS17205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7X90_RS17215	COG0045	succinate-CoA ligase (ADP-forming) activity
H7X90_RS17250	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7X90_RS17275	COG0745	RESPONSE REGULATOR receiver
H7X90_RS17290	COG0189	ligase activity
H7X90_RS17310	COG0583	DNA-binding transcription factor activity
H7X90_RS17315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7X90_RS17320	COG0501	Belongs to the peptidase M48B family
H7X90_RS17365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7X90_RS17375	COG0542	response to heat
H7X90_RS17380	COG0071	Belongs to the small heat shock protein (HSP20) family
H7X90_RS17405	COG0583	DNA-binding transcription factor activity
H7X90_RS17420	COG1192	Involved in chromosome partitioning
H7X90_RS17465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7X90_RS17575	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H7X90_RS17590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7X90_RS17650	COG2003	Belongs to the UPF0758 family
H7X90_RS17720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7X90_RS17775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7X90_RS17805	COG2826	transposase and inactivated derivatives, IS30 family
H7X90_RS17825	COG0789	Transcriptional regulator
H7X90_RS17855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7X90_RS17865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7X90_RS17880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7X90_RS17895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7X90_RS17900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7X90_RS17905	COG1017	nitric oxide dioxygenase activity
H7X90_RS17905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7X90_RS17915	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H7X90_RS18020	COG0582	viral genome integration into host DNA
H7X90_RS18030	COG4625	pathogenesis
H7X90_RS18030	COG3240	lipase activity
H7X90_RS18040	COG2022	thiamine diphosphate biosynthetic process
H7X90_RS18045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7X90_RS18050	COG3273	potassium ion transport
H7X90_RS18050	COG0471	metal ion transport
H7X90_RS18070	COG1970	mechanosensitive ion channel activity
H7X90_RS18080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7X90_RS18085	COG1115	amino acid carrier protein
H7X90_RS18095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7X90_RS18100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7X90_RS18125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H7X90_RS18135	COG3588	fructose-bisphosphate aldolase
H7X90_RS18140	COG0469	pyruvate kinase activity
H7X90_RS18150	COG0126	phosphoglycerate kinase activity
H7X90_RS18165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7X90_RS18210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7X90_RS18215	COG1301	dicarboxylic acid transport
H7X90_RS18245	COG0714	Associated with various cellular activities
H7X90_RS18275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7X90_RS18315	COG3111	PFAM Bacterial OB fold (BOF) protein
H7X90_RS18325	COG0254	rRNA binding
H7X90_RS18335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7X90_RS18345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7X90_RS18350	COG1758	RNA polymerase activity
H7X90_RS18365	COG0437	4 iron, 4 sulfur cluster binding
H7X90_RS18370	COG2864	formate dehydrogenase
H7X90_RS18380	COG1921	L-seryl-tRNASec selenium transferase activity
H7X90_RS18385	COG3276	selenocysteine insertion sequence binding
H7X90_RS18395	COG0709	Synthesizes selenophosphate from selenide and ATP
H7X90_RS18400	COG1561	YicC-like family, N-terminal region
H7X90_RS18405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7X90_RS18410	COG0346	lactoylglutathione lyase activity
H7X90_RS18420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7X90_RS18435	COG0006	proline dipeptidase activity
H7X90_RS18440	COG0006	proline dipeptidase activity
H7X90_RS18445	COG3079	Belongs to the UPF0149 family
H7X90_RS18465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7X90_RS18475	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7X90_RS18485	COG2912	Transglutaminase-like superfamily
H7X90_RS18490	COG1773	rubredoxin
H7X90_RS18500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7X90_RS18505	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H7X90_RS18515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7X90_RS18520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7X90_RS18530	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS18550	COG0671	phosphoesterase, PA-phosphatase related
H7X90_RS18560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7X90_RS18565	COG0563	adenylate kinase activity
H7X90_RS18585	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H7X90_RS18595	COG0848	biopolymer transport protein
H7X90_RS18605	COG2832	Protein of unknown function (DUF454)
H7X90_RS18640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7X90_RS18665	COG0745	RESPONSE REGULATOR receiver
H7X90_RS18675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7X90_RS18680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7X90_RS18685	COG0405	Gamma-glutamyltransferase
H7X90_RS18690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7X90_RS18710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7X90_RS18715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7X90_RS18730	COG0473	3-isopropylmalate dehydrogenase activity
H7X90_RS18740	COG0583	DNA-binding transcription factor activity
H7X90_RS18745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7X90_RS18750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7X90_RS18760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7X90_RS18765	COG1538	Outer membrane efflux protein
H7X90_RS18770	COG0531	amino acid
H7X90_RS18775	COG1519	Transferase
H7X90_RS18780	COG1560	Kdo2-lipid A biosynthetic process
H7X90_RS18815	COG1301	dicarboxylic acid transport
H7X90_RS18825	COG4191	Histidine kinase
H7X90_RS18840	COG0642	Histidine kinase
H7X90_RS18855	COG2851	Citrate transporter
H7X90_RS18860	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS18880	COG1162	GTPase activity
H7X90_RS18885	COG0436	Aminotransferase
H7X90_RS18905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7X90_RS18920	COG1228	amidohydrolase
H7X90_RS18925	COG0804	urea catabolic process
H7X90_RS18935	COG1307	EDD domain protein, DegV family
H7X90_RS18975	COG2203	Gaf domain
H7X90_RS18975	COG3706	GGDEF domain
H7X90_RS18975	COG4251	negative regulation of phosphorylation
H7X90_RS18975	COG5001	Diguanylate cyclase
H7X90_RS18980	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7X90_RS18990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7X90_RS19010	COG1902	pentaerythritol trinitrate reductase activity
H7X90_RS19035	COG0583	DNA-binding transcription factor activity
H7X90_RS19040	COG1064	alcohol dehydrogenase
H7X90_RS19060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7X90_RS19065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7X90_RS19075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7X90_RS19080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7X90_RS19095	COG1522	sequence-specific DNA binding
H7X90_RS19105	COG4773	Receptor
H7X90_RS19135	COG0617	tRNA 3'-terminal CCA addition
H7X90_RS19170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7X90_RS19175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7X90_RS19180	COG1609	Transcriptional regulator
H7X90_RS19190	COG0837	glucose binding
H7X90_RS19200	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H7X90_RS19220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7X90_RS19245	COG4191	Histidine kinase
H7X90_RS19250	COG0784	Response regulator, receiver
H7X90_RS19255	COG4251	negative regulation of phosphorylation
H7X90_RS19260	COG2823	Periplasmic or secreted lipoprotein
H7X90_RS19265	COG0673	inositol 2-dehydrogenase activity
H7X90_RS19270	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H7X90_RS19290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7X90_RS19300	COG2921	Belongs to the UPF0250 family
H7X90_RS19310	COG1686	Belongs to the peptidase S11 family
H7X90_RS19315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7X90_RS19320	COG2951	lytic endotransglycosylase activity
H7X90_RS19325	COG0772	Belongs to the SEDS family
H7X90_RS19330	COG0772	Belongs to the SEDS family
H7X90_RS19345	COG1792	Involved in formation and maintenance of cell shape
H7X90_RS19350	COG1077	Cell shape determining protein MreB Mrl
H7X90_RS19355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7X90_RS19370	COG0308	aminopeptidase N
H7X90_RS19375	COG2226	methyltransferase
H7X90_RS19405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7X90_RS19420	COG0673	inositol 2-dehydrogenase activity
H7X90_RS19430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7X90_RS19445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7X90_RS19455	COG2832	Protein of unknown function (DUF454)
H7X90_RS19465	COG0436	Aminotransferase
H7X90_RS19470	COG1505	serine-type exopeptidase activity
H7X90_RS19495	COG0697	spore germination
H7X90_RS19500	COG1666	GTP binding
H7X90_RS19515	COG0339	signal peptide processing
H7X90_RS19525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7X90_RS19545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7X90_RS19555	COG1136	(ABC) transporter
H7X90_RS19560	COG1136	(ABC) transporter
H7X90_RS19560	COG0577	efflux transmembrane transporter activity
H7X90_RS19565	COG0577	efflux transmembrane transporter activity
H7X90_RS19575	COG2204	response regulator
H7X90_RS19580	COG4191	Histidine kinase
H7X90_RS19590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7X90_RS19600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7X90_RS19605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7X90_RS19610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7X90_RS19615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7X90_RS19620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7X90_RS19625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7X90_RS19635	COG0356	it plays a direct role in the translocation of protons across the membrane
H7X90_RS19650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7X90_RS19655	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7X90_RS19675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7X90_RS19700	COG0181	hydroxymethylbilane synthase activity
H7X90_RS19710	COG0745	RESPONSE REGULATOR receiver
H7X90_RS19710	COG2972	Histidine kinase
H7X90_RS19715	COG0400	carboxylic ester hydrolase activity
H7X90_RS19725	COG4771	TonB-dependent receptor
H7X90_RS19755	COG0477	Major facilitator Superfamily
H7X90_RS19800	COG4206	TonB-dependent receptor
H7X90_RS19820	COG0625	glutathione transferase activity
H7X90_RS19835	COG2259	Doxx family
H7X90_RS19860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7X90_RS19930	COG0210	DNA helicase
H7X90_RS19940	COG0210	DNA helicase
H7X90_RS19980	COG2003	Belongs to the UPF0758 family
H7X90_RS20035	COG0582	viral genome integration into host DNA
H7X90_RS20050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7X90_RS20055	COG1490	D-aminoacyl-tRNA deacylase activity
H7X90_RS20065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7X90_RS20105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7X90_RS20105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7X90_RS20110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7X90_RS20115	COG0242	peptide deformylase activity
H7X90_RS20125	COG0758	DNA mediated transformation
H7X90_RS20130	COG2922	Belongs to the Smg family
H7X90_RS20140	COG1714	RDD family
H7X90_RS20145	COG1754	DNA topoisomerase type I activity
H7X90_RS20145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7X90_RS20150	COG0009	L-threonylcarbamoyladenylate synthase
H7X90_RS20165	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS20175	COG0616	signal peptide processing
H7X90_RS20180	COG0534	Mate efflux family protein
H7X90_RS20195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7X90_RS20200	COG0625	glutathione transferase activity
H7X90_RS20210	COG1252	NADH dehydrogenase
H7X90_RS20230	COG2860	membrane
H7X90_RS20235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7X90_RS20255	COG1846	Transcriptional regulator
H7X90_RS20285	COG0459	protein refolding
H7X90_RS20290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7X90_RS20295	COG2356	endonuclease I
H7X90_RS20300	COG1324	tolerance protein
H7X90_RS20310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7X90_RS20320	COG0840	transmembrane signaling receptor activity
H7X90_RS20340	COG4585	Histidine kinase
H7X90_RS20360	COG0583	DNA-binding transcription factor activity
H7X90_RS20375	COG1785	Belongs to the alkaline phosphatase family
H7X90_RS20380	COG1686	Belongs to the peptidase S11 family
H7X90_RS20390	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7X90_RS20400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7X90_RS20410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7X90_RS20415	COG0511	ligase activity, forming carbon-carbon bonds
H7X90_RS20420	COG0439	Biotin carboxylase
H7X90_RS20435	COG2264	protein methyltransferase activity
H7X90_RS20445	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7X90_RS20450	COG4589	Belongs to the CDS family
H7X90_RS20455	COG0204	Acyl-transferase
H7X90_RS20465	COG0671	phosphoesterase, PA-phosphatase related
H7X90_RS20465	COG2453	phosphatase
H7X90_RS20470	COG2267	carboxylic ester hydrolase activity
H7X90_RS20475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7X90_RS20480	COG0138	bifunctional purine biosynthesis protein purh
H7X90_RS20485	COG0151	Belongs to the GarS family
H7X90_RS20500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7X90_RS20505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7X90_RS20510	COG2201	protein-glutamate methylesterase activity
H7X90_RS20515	COG2177	Part of the ABC transporter FtsEX involved in
H7X90_RS20520	COG2884	Cell division ATP-binding protein ftsE
H7X90_RS20530	COG3118	belongs to the thioredoxin family
H7X90_RS20535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H7X90_RS20540	COG3706	GGDEF domain
H7X90_RS20550	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7X90_RS20585	COG1652	LysM domain
H7X90_RS20590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7X90_RS20590	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7X90_RS20595	COG1473	amidohydrolase
H7X90_RS20600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7X90_RS20605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7X90_RS20610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7X90_RS20615	COG1289	transmembrane transporter activity
H7X90_RS20620	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS20625	COG2814	Major facilitator Superfamily
H7X90_RS20655	COG0316	Belongs to the HesB IscA family
H7X90_RS20695	COG1051	belongs to the nudix hydrolase family
H7X90_RS20710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7X90_RS20715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7X90_RS20720	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H7X90_RS20730	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H7X90_RS20735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7X90_RS20740	COG0730	response to heat
H7X90_RS20750	COG0134	indole-3-glycerol-phosphate synthase activity
H7X90_RS20755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7X90_RS20775	COG1597	lipid kinase activity
H7X90_RS20790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7X90_RS20795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7X90_RS20805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7X90_RS20805	COG2111	Na H antiporter
H7X90_RS20810	COG1006	Multisubunit Na H antiporter MnhC subunit
H7X90_RS20815	COG0651	ATP synthesis coupled electron transport
H7X90_RS20820	COG1863	multisubunit Na H antiporter MnhE subunit
H7X90_RS20825	COG2212	antiporter activity
H7X90_RS20830	COG1320	monovalent cation:proton antiporter activity
H7X90_RS20835	COG0530	calcium, potassium:sodium antiporter activity
H7X90_RS20850	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7X90_RS20865	COG4804	nuclease activity
H7X90_RS20880	COG3104	oligopeptide transport
H7X90_RS20885	COG3483	tryptophan 2,3-dioxygenase activity
H7X90_RS20915	COG2378	regulation of single-species biofilm formation
H7X90_RS20930	COG2354	Protein conserved in bacteria
H7X90_RS20935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7X90_RS20940	COG1368	sulfuric ester hydrolase activity
H7X90_RS20945	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7X90_RS20945	COG3264	Mechanosensitive ion channel
H7X90_RS20950	COG2801	Transposase and inactivated derivatives
H7X90_RS20950	COG3415	Transposase
H7X90_RS20965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7X90_RS21005	COG1166	arginine decarboxylase activity
H7X90_RS21010	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7X90_RS21030	COG2960	long-chain fatty acid transporting porin activity
H7X90_RS21085	COG0606	chelatase, subunit chli
H7X90_RS21090	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H7X90_RS21130	COG0561	phosphatase activity
H7X90_RS21135	COG3932	Exopolysaccharide synthesis, ExoD
H7X90_RS21160	COG1999	signal sequence binding
H7X90_RS21165	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7X90_RS21170	COG1845	cytochrome c oxidase, subunit III
H7X90_RS21180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7X90_RS21185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7X90_RS21200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7X90_RS21260	COG2031	fatty acid transporter
H7X90_RS21295	COG3415	Transposase
H7X90_RS21295	COG2801	Transposase and inactivated derivatives
H7X90_RS21310	COG0673	inositol 2-dehydrogenase activity
H7X90_RS21320	COG1501	Belongs to the glycosyl hydrolase 31 family
H7X90_RS21325	COG2222	sugar isomerase
H7X90_RS21330	COG1940	carbohydrate kinase activity
H7X90_RS21340	COG1349	DNA-binding transcription factor activity
H7X90_RS21345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7X90_RS21350	COG2814	Major facilitator Superfamily
H7X90_RS21375	COG3210	domain, Protein
H7X90_RS21400	COG1040	competence protein
H7X90_RS21420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7X90_RS21425	COG0156	8-amino-7-oxononanoate synthase activity
H7X90_RS21430	COG2267	carboxylic ester hydrolase activity
H7X90_RS21435	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS21450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7X90_RS21470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7X90_RS21475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7X90_RS21480	COG2205	protein histidine kinase activity
H7X90_RS21485	COG0745	RESPONSE REGULATOR receiver
H7X90_RS21490	COG3541	Predicted nucleotidyltransferase
H7X90_RS21495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7X90_RS21520	COG0714	Associated with various cellular activities
H7X90_RS21535	COG0754	glutathionylspermidine amidase activity
H7X90_RS21550	COG0129	dihydroxy-acid dehydratase activity
H7X90_RS21555	COG1199	ATP-dependent helicase activity
H7X90_RS21565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7X90_RS21585	COG3781	membrane
H7X90_RS21615	COG0625	glutathione transferase activity
H7X90_RS21635	COG2207	Transcriptional regulator
H7X90_RS21650	COG4555	ABC transporter
H7X90_RS21680	COG0543	2 iron, 2 sulfur cluster binding
H7X90_RS21680	COG0633	Ferredoxin
H7X90_RS21685	COG1131	(ABC) transporter
H7X90_RS21690	COG0842	Transport permease protein
H7X90_RS21700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7X90_RS21710	COG0084	hydrolase, TatD family'
H7X90_RS21715	COG1643	Atp-dependent helicase
H7X90_RS21725	COG1187	pseudouridine synthase activity
H7X90_RS21740	COG0667	Aldo Keto reductase
H7X90_RS21755	COG1690	Belongs to the RtcB family
H7X90_RS21770	COG0840	transmembrane signaling receptor activity
H7X90_RS21775	COG0583	DNA-binding transcription factor activity
H7X90_RS21780	COG2814	Major facilitator Superfamily
H7X90_RS21785	COG0656	L-ascorbic acid biosynthetic process
H7X90_RS21805	COG2267	carboxylic ester hydrolase activity
H7X90_RS21835	COG1042	CoA-binding domain protein
H7X90_RS21835	COG0045	succinate-CoA ligase (ADP-forming) activity
H7X90_RS21835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7X90_RS21840	COG2239	Acts as a magnesium transporter
H7X90_RS21850	COG0666	response to abiotic stimulus
H7X90_RS21850	COG3177	Filamentation induced by cAMP protein fic
H7X90_RS21855	COG3100	YcgL domain-containing protein
H7X90_RS21865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7X90_RS21870	COG1028	Short-chain dehydrogenase reductase Sdr
H7X90_RS21890	COG0644	oxidoreductase
H7X90_RS21910	COG2986	histidine ammonia-lyase
H7X90_RS21920	COG0463	Glycosyl transferase, family 2
H7X90_RS21935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7X90_RS21940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7X90_RS21955	COG1294	oxidase, subunit
H7X90_RS21960	COG1271	oxidase subunit
H7X90_RS22015	COG0408	coproporphyrinogen oxidase activity
H7X90_RS22025	COG2323	membrane
H7X90_RS22040	COG0589	response to stress
H7X90_RS22065	COG0210	DNA helicase
H7X90_RS22075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7X90_RS22080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7X90_RS22085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7X90_RS22090	COG1819	glycosyl
H7X90_RS22105	COG0251	oxidation-reduction process
H7X90_RS22140	COG0463	Glycosyl transferase, family 2
H7X90_RS22155	COG1475	DNA binding
H7X90_RS22160	COG1192	Involved in chromosome partitioning
H7X90_RS22165	COG0357	Ribosomal RNA small subunit methyltransferase G
H7X90_RS22170	COG2091	lysine biosynthetic process via aminoadipic acid
H7X90_RS22210	COG1971	Probably functions as a manganese efflux pump
H7X90_RS22215	COG2205	protein histidine kinase activity
H7X90_RS22215	COG0784	Response regulator, receiver
H7X90_RS22225	COG0443	Heat shock 70 kDa protein
H7X90_RS22240	COG2911	Protein conserved in bacteria
H7X90_RS22245	COG0729	surface antigen
H7X90_RS22255	COG0752	glycyl-tRNA synthetase alpha subunit
H7X90_RS22260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7X90_RS22265	COG0519	Catalyzes the synthesis of GMP from XMP
H7X90_RS22265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7X90_RS22275	COG0805	protein transport
H7X90_RS22285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7X90_RS22295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7X90_RS22300	COG0596	Alpha beta hydrolase
H7X90_RS22300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7X90_RS22305	COG0840	transmembrane signaling receptor activity
H7X90_RS22365	COG3135	benzoate transporter
H7X90_RS22380	COG2951	lytic endotransglycosylase activity
H7X90_RS22385	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H7X90_RS22390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7X90_RS22395	COG3706	GGDEF domain
H7X90_RS22425	COG0302	gtp cyclohydrolase
H7X90_RS22450	COG1289	transmembrane transporter activity
H7X90_RS22465	COG1074	ATP-dependent DNA helicase activity
H7X90_RS22470	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7X90_RS22475	COG1127	ABC transporter
H7X90_RS22480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7X90_RS22485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7X90_RS22500	COG2853	Lipoprotein
H7X90_RS22505	COG0386	Belongs to the glutathione peroxidase family
H7X90_RS22515	COG1322	Protein conserved in bacteria
H7X90_RS22525	COG0604	alcohol dehydrogenase
H7X90_RS22530	COG0583	DNA-binding transcription factor activity
H7X90_RS22550	COG0531	amino acid
H7X90_RS22560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7X90_RS22565	COG0861	Integral membrane protein TerC family
H7X90_RS22575	COG0584	glycerophosphoryl diester phosphodiesterase
H7X90_RS22590	COG0706	membrane insertase activity
H7X90_RS22595	COG0594	ribonuclease P activity
H7X90_RS22600	COG0230	Belongs to the bacterial ribosomal protein bL34 family