locus-tag	class	description
EZ304_RS00010	COG0745	RESPONSE REGULATOR receiver
EZ304_RS00015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS00020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS00040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EZ304_RS00080	COG2249	NAD(P)H dehydrogenase (quinone) activity
EZ304_RS00090	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS00095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EZ304_RS00100	COG0505	Belongs to the CarA family
EZ304_RS00105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EZ304_RS00110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZ304_RS00120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EZ304_RS00130	COG4676	Protein conserved in bacteria
EZ304_RS00145	COG1012	belongs to the aldehyde dehydrogenase family
EZ304_RS00155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EZ304_RS00165	COG2205	protein histidine kinase activity
EZ304_RS00165	COG0784	Response regulator, receiver
EZ304_RS00165	COG2198	Histidine kinase
EZ304_RS00175	COG1024	Enoyl-CoA hydratase
EZ304_RS00180	COG0318	PFAM AMP-dependent synthetase and ligase
EZ304_RS00185	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EZ304_RS00190	COG1012	belongs to the aldehyde dehydrogenase family
EZ304_RS00195	COG1309	transcriptional regulator
EZ304_RS00200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EZ304_RS00255	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EZ304_RS00265	COG0840	transmembrane signaling receptor activity
EZ304_RS00275	COG0840	transmembrane signaling receptor activity
EZ304_RS00285	COG0835	chemotaxis
EZ304_RS00290	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EZ304_RS00295	COG0840	transmembrane signaling receptor activity
EZ304_RS00305	COG0745	RESPONSE REGULATOR receiver
EZ304_RS00315	COG0835	chemotaxis
EZ304_RS00325	COG1360	Flagellar Motor Protein
EZ304_RS00330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EZ304_RS00335	COG0643	Histidine kinase
EZ304_RS00335	COG2198	Histidine kinase
EZ304_RS00335	COG0784	Response regulator, receiver
EZ304_RS00340	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EZ304_RS00365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EZ304_RS00370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EZ304_RS00395	COG1987	bacterial-type flagellum assembly
EZ304_RS00405	COG3190	flagellar
EZ304_RS00455	COG1677	Flagellar hook-basal body complex protein FliE
EZ304_RS00480	COG2197	response regulator
EZ304_RS00500	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EZ304_RS00505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EZ304_RS00540	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EZ304_RS00550	COG4787	bacterial-type flagellum-dependent cell motility
EZ304_RS00565	COG1558	bacterial-type flagellum-dependent cell motility
EZ304_RS00575	COG0784	Response regulator, receiver
EZ304_RS00575	COG0835	chemotaxis
EZ304_RS00595	COG5002	protein histidine kinase activity
EZ304_RS00635	COG2915	High frequency lysogenization protein hflD homolog
EZ304_RS00640	COG0482	sulfurtransferase activity
EZ304_RS00655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EZ304_RS00665	COG0542	response to heat
EZ304_RS00700	COG0492	ferredoxin-NADP+ reductase activity
EZ304_RS00705	COG1674	ftsk spoiiie
EZ304_RS00715	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EZ304_RS00720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EZ304_RS00735	COG2819	hydrolase of the alpha beta superfamily
EZ304_RS00745	COG4558	Periplasmic binding protein
EZ304_RS00750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZ304_RS00755	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EZ304_RS00765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EZ304_RS00805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZ304_RS00820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZ304_RS00830	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EZ304_RS00845	COG1595	DNA-templated transcription, initiation
EZ304_RS00865	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EZ304_RS01015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EZ304_RS01020	COG0583	DNA-binding transcription factor activity
EZ304_RS01055	COG0322	excinuclease ABC activity
EZ304_RS01085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZ304_RS01090	COG5265	(ABC) transporter
EZ304_RS01130	COG2207	Transcriptional regulator
EZ304_RS01145	COG0596	Alpha beta hydrolase
EZ304_RS01155	COG2205	protein histidine kinase activity
EZ304_RS01165	COG0318	PFAM AMP-dependent synthetase and ligase
EZ304_RS01210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZ304_RS01230	COG0583	DNA-binding transcription factor activity
EZ304_RS01255	COG2204	response regulator
EZ304_RS01355	COG2084	Dehydrogenase
EZ304_RS01405	COG5002	protein histidine kinase activity
EZ304_RS01405	COG3447	MASE1 domain protein
EZ304_RS01405	COG5001	Diguanylate cyclase
EZ304_RS01410	COG0577	efflux transmembrane transporter activity
EZ304_RS01410	COG1136	(ABC) transporter
EZ304_RS01415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS01425	COG0745	RESPONSE REGULATOR receiver
EZ304_RS01430	COG2205	protein histidine kinase activity
EZ304_RS01450	COG4774	siderophore transport
EZ304_RS01475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZ304_RS01480	COG3214	Protein conserved in bacteria
EZ304_RS01490	COG4774	siderophore transport
EZ304_RS01495	COG3121	Chaperone
EZ304_RS01505	COG3121	Chaperone
EZ304_RS01515	COG3188	usher protein
EZ304_RS01540	COG2197	response regulator
EZ304_RS01555	COG0784	Response regulator, receiver
EZ304_RS01555	COG2205	protein histidine kinase activity
EZ304_RS01585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EZ304_RS01590	COG1285	pathogenesis
EZ304_RS01595	COG4191	Histidine kinase
EZ304_RS01600	COG4566	intracellular signal transduction
EZ304_RS01660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EZ304_RS01680	COG0477	Major facilitator Superfamily
EZ304_RS01720	COG0583	DNA-binding transcription factor activity
EZ304_RS01725	COG0656	L-ascorbic acid biosynthetic process
EZ304_RS01745	COG2372	response to copper ion
EZ304_RS01760	COG5002	protein histidine kinase activity
EZ304_RS01765	COG0583	DNA-binding transcription factor activity
EZ304_RS01770	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS01795	COG0642	Histidine kinase
EZ304_RS01800	COG3537	Alpha-1,2-mannosidase
EZ304_RS01820	COG0477	Major facilitator Superfamily
EZ304_RS01840	COG3920	Histidine kinase
EZ304_RS01840	COG2202	Pas domain
EZ304_RS01845	COG2205	protein histidine kinase activity
EZ304_RS01845	COG0784	Response regulator, receiver
EZ304_RS01845	COG2198	Histidine kinase
EZ304_RS01875	COG4771	TonB-dependent receptor
EZ304_RS01880	COG1429	ligase activity, forming nitrogen-metal bonds
EZ304_RS01905	COG1335	isochorismatase
EZ304_RS01910	COG1335	isochorismatase
EZ304_RS01940	COG0811	peptide transport
EZ304_RS02065	COG0840	transmembrane signaling receptor activity
EZ304_RS02070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EZ304_RS02090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EZ304_RS02095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZ304_RS02100	COG1120	ATPase activity
EZ304_RS02110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EZ304_RS02115	COG4149	molybdate abc transporter
EZ304_RS02120	COG0725	ABC transporter, periplasmic molybdate-binding protein
EZ304_RS02125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZ304_RS02140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZ304_RS02145	COG2181	nitrate reductase activity
EZ304_RS02150	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EZ304_RS02155	COG1140	nitrate reductase beta subunit
EZ304_RS02160	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EZ304_RS02165	COG2223	nitrite transmembrane transporter activity
EZ304_RS02175	COG0746	molybdenum cofactor guanylyltransferase activity
EZ304_RS02180	COG0314	molybdopterin synthase activity
EZ304_RS02190	COG0303	'Molybdopterin
EZ304_RS02195	COG0521	Mo-molybdopterin cofactor biosynthetic process
EZ304_RS02195	COG0315	cyclic pyranopterin monophosphate synthase activity
EZ304_RS02200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EZ304_RS02285	COG2205	protein histidine kinase activity
EZ304_RS02295	COG2194	sulfuric ester hydrolase activity
EZ304_RS02315	COG2885	chlorophyll binding
EZ304_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS02340	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EZ304_RS02340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZ304_RS02350	COG3433	isochorismatase activity
EZ304_RS02350	COG1535	isochorismatase
EZ304_RS02355	COG1021	2,3-dihydroxybenzoate-AMP ligase
EZ304_RS02360	COG1169	isochorismate synthase
EZ304_RS02370	COG2409	Drug exporters of the RND superfamily
EZ304_RS02375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZ304_RS02435	COG1914	H( )-stimulated, divalent metal cation uptake system
EZ304_RS02450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZ304_RS02455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZ304_RS02460	COG0604	alcohol dehydrogenase
EZ304_RS02460	COG3321	synthase
EZ304_RS02460	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS02465	COG4206	TonB-dependent receptor
EZ304_RS02470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EZ304_RS02480	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EZ304_RS02485	COG2205	protein histidine kinase activity
EZ304_RS02490	COG0745	RESPONSE REGULATOR receiver
EZ304_RS02535	COG4772	TonB-dependent receptor
EZ304_RS02555	COG2226	methyltransferase
EZ304_RS02600	COG4964	Belongs to the GSP D family
EZ304_RS02655	COG2814	Major facilitator Superfamily
EZ304_RS02665	COG1228	amidohydrolase
EZ304_RS02675	COG1335	isochorismatase
EZ304_RS02690	COG3850	Histidine kinase
EZ304_RS02695	COG2197	response regulator
EZ304_RS02700	COG2814	Major facilitator Superfamily
EZ304_RS02725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EZ304_RS02735	COG0583	DNA-binding transcription factor activity
EZ304_RS02750	COG3161	chorismate lyase activity
EZ304_RS02795	COG0277	FAD linked oxidase domain protein
EZ304_RS02800	COG1304	FMN binding
EZ304_RS02805	COG2186	Transcriptional regulator
EZ304_RS02815	COG1285	pathogenesis
EZ304_RS02905	COG0587	DNA-directed DNA polymerase activity
EZ304_RS02920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EZ304_RS02925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZ304_RS02925	COG0519	Catalyzes the synthesis of GMP from XMP
EZ304_RS02950	COG4206	TonB-dependent receptor
EZ304_RS02950	COG1629	transport
EZ304_RS02980	COG0531	amino acid
EZ304_RS02995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZ304_RS03005	COG0789	Transcriptional regulator
EZ304_RS03090	COG5002	protein histidine kinase activity
EZ304_RS03090	COG5001	Diguanylate cyclase
EZ304_RS03090	COG3447	MASE1 domain protein
EZ304_RS03095	COG2183	response to ionizing radiation
EZ304_RS03120	COG3243	poly(R)-hydroxyalkanoic acid synthase
EZ304_RS03140	COG0534	Mate efflux family protein
EZ304_RS03160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EZ304_RS03175	COG0668	transmembrane transport
EZ304_RS03180	COG1902	pentaerythritol trinitrate reductase activity
EZ304_RS03190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EZ304_RS03200	COG1733	regulation of RNA biosynthetic process
EZ304_RS03205	COG2249	NAD(P)H dehydrogenase (quinone) activity
EZ304_RS03290	COG3702	type iv secretory pathway
EZ304_RS03310	COG2948	multi-organism process
EZ304_RS03320	COG3736	Type IV secretory pathway, component VirB8
EZ304_RS03330	COG3505	Type IV secretory pathway VirD4
EZ304_RS03340	COG2814	Major facilitator Superfamily
EZ304_RS03345	COG0789	Transcriptional regulator
EZ304_RS03370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZ304_RS03380	COG4774	siderophore transport
EZ304_RS03395	COG0745	RESPONSE REGULATOR receiver
EZ304_RS03415	COG0577	efflux transmembrane transporter activity
EZ304_RS03415	COG1136	(ABC) transporter
EZ304_RS03435	COG1733	regulation of RNA biosynthetic process
EZ304_RS03440	COG0604	alcohol dehydrogenase
EZ304_RS03450	COG0210	DNA helicase
EZ304_RS03485	COG0583	DNA-binding transcription factor activity
EZ304_RS03490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EZ304_RS03500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EZ304_RS03515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EZ304_RS03520	COG1605	Chorismate mutase
EZ304_RS03520	COG0077	Prephenate dehydratase
EZ304_RS03525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EZ304_RS03560	COG1228	amidohydrolase
EZ304_RS03575	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EZ304_RS03630	COG2957	Belongs to the agmatine deiminase family
EZ304_RS03635	COG0583	DNA-binding transcription factor activity
EZ304_RS03725	COG4993	Dehydrogenase
EZ304_RS03735	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EZ304_RS03745	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EZ304_RS03755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EZ304_RS03760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZ304_RS03765	COG3115	cell septum assembly
EZ304_RS03775	COG0359	binds to the 23S rRNA
EZ304_RS03780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EZ304_RS03785	COG0360	Binds together with S18 to 16S ribosomal RNA
EZ304_RS03795	COG0316	Belongs to the HesB IscA family
EZ304_RS03800	COG0017	Asparaginyl-tRNA synthetase
EZ304_RS03820	COG0288	reversible hydration of carbon dioxide
EZ304_RS03830	COG3844	kynureninase activity
EZ304_RS03835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZ304_RS03840	COG2925	Exonuclease
EZ304_RS03865	COG2902	Dehydrogenase
EZ304_RS03875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS03880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS03895	COG1960	acyl-CoA dehydrogenase activity
EZ304_RS03910	COG0646	methionine synthase
EZ304_RS03910	COG1410	methionine synthase
EZ304_RS03925	COG2900	Belongs to the SlyX family
EZ304_RS03940	COG0386	Belongs to the glutathione peroxidase family
EZ304_RS03950	COG1725	Transcriptional regulator
EZ304_RS03955	COG1131	(ABC) transporter
EZ304_RS03980	COG0114	fumarate hydratase activity
EZ304_RS03990	COG2850	peptidyl-arginine hydroxylation
EZ304_RS04000	COG0567	Dehydrogenase, E1 component
EZ304_RS04015	COG0583	DNA-binding transcription factor activity
EZ304_RS04035	COG3540	Alkaline phosphatase
EZ304_RS04045	COG0305	Participates in initiation and elongation during chromosome replication
EZ304_RS04065	COG0625	glutathione transferase activity
EZ304_RS04085	COG0084	hydrolase, TatD family'
EZ304_RS04090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EZ304_RS04120	COG1393	Belongs to the ArsC family
EZ304_RS04125	COG0625	glutathione transferase activity
EZ304_RS04140	COG1595	DNA-templated transcription, initiation
EZ304_RS04150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZ304_RS04165	COG0386	Belongs to the glutathione peroxidase family
EZ304_RS04170	COG0339	signal peptide processing
EZ304_RS04175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZ304_RS04195	COG0705	Rhomboid family
EZ304_RS04200	COG3104	oligopeptide transport
EZ304_RS04210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EZ304_RS04215	COG4290	ribonuclease
EZ304_RS04230	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EZ304_RS04230	COG0316	Belongs to the HesB IscA family
EZ304_RS04235	COG2154	pterin-4-alpha-carbinolamine dehydratase
EZ304_RS04245	COG0428	transporter
EZ304_RS04255	COG1530	ribonuclease E activity
EZ304_RS04270	COG0395	ABC-type sugar transport system, permease component
EZ304_RS04295	COG1609	Transcriptional regulator
EZ304_RS04300	COG0271	Belongs to the BolA IbaG family
EZ304_RS04305	COG2350	Protein conserved in bacteria
EZ304_RS04310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EZ304_RS04315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EZ304_RS04320	COG1187	pseudouridine synthase activity
EZ304_RS04335	COG2814	Major facilitator Superfamily
EZ304_RS04350	COG0436	Aminotransferase
EZ304_RS04355	COG4133	protoheme IX ABC transporter activity
EZ304_RS04375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EZ304_RS04390	COG3088	subunit of a heme lyase
EZ304_RS04390	COG4235	cytochrome complex assembly
EZ304_RS04400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZ304_RS04410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EZ304_RS04415	COG4988	ABC transporter
EZ304_RS04425	COG1294	oxidase, subunit
EZ304_RS04455	COG0726	polysaccharide deacetylase
EZ304_RS04455	COG1649	PFAM Uncharacterised BCR, COG1649
EZ304_RS04460	COG1215	transferase activity, transferring glycosyl groups
EZ304_RS04470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EZ304_RS04485	COG0165	Argininosuccinate lyase
EZ304_RS04490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EZ304_RS04500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EZ304_RS04505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZ304_RS04510	COG0137	argininosuccinate synthase activity
EZ304_RS04515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EZ304_RS04530	COG2166	iron-sulfur cluster assembly
EZ304_RS04550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EZ304_RS04575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZ304_RS04580	COG0402	S-adenosylhomocysteine deaminase activity
EZ304_RS04585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EZ304_RS04590	COG1509	lysine 2,3-aminomutase activity
EZ304_RS04595	COG3300	MHYT domain
EZ304_RS04595	COG5001	Diguanylate cyclase
EZ304_RS04620	COG0501	Belongs to the peptidase M48B family
EZ304_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS04650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EZ304_RS04655	COG0860	N-Acetylmuramoyl-L-alanine amidase
EZ304_RS04660	COG0802	atpase or kinase
EZ304_RS04665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EZ304_RS04665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EZ304_RS04670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EZ304_RS04675	COG1570	exodeoxyribonuclease VII activity
EZ304_RS04685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZ304_RS04700	COG4771	TonB-dependent receptor
EZ304_RS04705	COG1309	transcriptional regulator
EZ304_RS04735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZ304_RS04735	COG2169	Transcriptional regulator
EZ304_RS04740	COG2130	NADP-dependent
EZ304_RS04765	COG1960	acyl-CoA dehydrogenase activity
EZ304_RS04775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EZ304_RS04805	COG1309	transcriptional regulator
EZ304_RS04810	COG2076	Multidrug Resistance protein
EZ304_RS04815	COG5487	UPF0391 membrane protein
EZ304_RS04820	COG1280	lysine exporter protein (LysE YggA)
EZ304_RS04825	COG1794	racemase activity, acting on amino acids and derivatives
EZ304_RS04860	COG0776	regulation of translation
EZ304_RS04865	COG0072	phenylalanine-tRNA ligase activity
EZ304_RS04865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ304_RS04870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EZ304_RS04875	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EZ304_RS04880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EZ304_RS04885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EZ304_RS04890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EZ304_RS04925	COG1185	polyribonucleotide nucleotidyltransferase activity
EZ304_RS04930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EZ304_RS04940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EZ304_RS04945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EZ304_RS04950	COG0195	Participates in both transcription termination and antitermination
EZ304_RS04955	COG0779	Required for maturation of 30S ribosomal subunits
EZ304_RS04970	COG1007	ATP synthesis coupled electron transport
EZ304_RS04985	COG0713	ATP synthesis coupled electron transport
EZ304_RS04995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZ304_RS05000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EZ304_RS05015	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EZ304_RS05020	COG0649	NAD binding
EZ304_RS05025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZ304_RS05030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZ304_RS05035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZ304_RS05050	COG0149	triose-phosphate isomerase activity
EZ304_RS05060	COG3083	sulfuric ester hydrolase activity
EZ304_RS05065	COG0438	transferase activity, transferring glycosyl groups
EZ304_RS05070	COG0726	polysaccharide deacetylase
EZ304_RS05075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EZ304_RS05085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZ304_RS05090	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EZ304_RS05095	COG0159	tryptophan synthase activity
EZ304_RS05105	COG0133	tryptophan synthase activity
EZ304_RS05140	COG0135	phosphoribosylanthranilate isomerase activity
EZ304_RS05145	COG0101	tRNA pseudouridine synthase activity
EZ304_RS05160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EZ304_RS05165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZ304_RS05170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EZ304_RS05175	COG2890	protein-(glutamine-N5) methyltransferase activity
EZ304_RS05180	COG1999	signal sequence binding
EZ304_RS05185	COG0688	phosphatidylethanolamine metabolic process
EZ304_RS05200	COG0433	COG0433 Predicted ATPase
EZ304_RS05205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZ304_RS05215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZ304_RS05220	COG0412	Dienelactone hydrolase
EZ304_RS05230	COG0717	Belongs to the dCTP deaminase family
EZ304_RS05240	COG0489	protein tyrosine kinase activity
EZ304_RS05245	COG4771	TonB-dependent receptor
EZ304_RS05250	COG4771	TonB-dependent receptor
EZ304_RS05260	COG3590	peptidase
EZ304_RS05290	COG0697	spore germination
EZ304_RS05300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZ304_RS05305	COG2311	Membrane
EZ304_RS05310	COG1047	Peptidyl-prolyl cis-trans
EZ304_RS05315	COG0791	NLP P60 protein
EZ304_RS05320	COG0791	NLP P60 protein
EZ304_RS05325	COG1301	dicarboxylic acid transport
EZ304_RS05345	COG1722	exodeoxyribonuclease VII activity
EZ304_RS05350	COG0142	geranyltranstransferase activity
EZ304_RS05360	COG0312	modulator of DNA gyrase
EZ304_RS05365	COG3028	Belongs to the UPF0307 family
EZ304_RS05370	COG0312	modulator of DNA gyrase
EZ304_RS05390	COG2968	Membrane
EZ304_RS05400	COG4771	TonB-dependent receptor
EZ304_RS05410	COG2755	lipolytic protein G-D-S-L family
EZ304_RS05410	COG0657	acetylesterase activity
EZ304_RS05420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EZ304_RS05430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EZ304_RS05445	COG0495	leucyl-tRNA aminoacylation
EZ304_RS05455	COG3118	belongs to the thioredoxin family
EZ304_RS05465	COG4251	negative regulation of phosphorylation
EZ304_RS05465	COG2203	Gaf domain
EZ304_RS05465	COG5001	Diguanylate cyclase
EZ304_RS05465	COG3706	GGDEF domain
EZ304_RS05490	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EZ304_RS05500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZ304_RS05505	COG0346	lactoylglutathione lyase activity
EZ304_RS05515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ304_RS05515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZ304_RS05525	COG2878	Part of a membrane complex involved in electron transport
EZ304_RS05530	COG0251	oxidation-reduction process
EZ304_RS05535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EZ304_RS05535	COG0392	lysyltransferase activity
EZ304_RS05565	COG2824	Alkylphosphonate utilization operon protein PhnA
EZ304_RS05570	COG0443	Heat shock 70 kDa protein
EZ304_RS05615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EZ304_RS05620	COG3122	Protein conserved in bacteria
EZ304_RS05625	COG1451	nucleotide metabolic process
EZ304_RS05635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EZ304_RS05655	COG0183	Belongs to the thiolase family
EZ304_RS05670	COG1960	acyl-CoA dehydrogenase activity
EZ304_RS05680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZ304_RS05685	COG1278	Cold shock
EZ304_RS05690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EZ304_RS05695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EZ304_RS05700	COG1472	Belongs to the glycosyl hydrolase 3 family
EZ304_RS05705	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EZ304_RS05710	COG2954	triphosphatase activity
EZ304_RS05715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EZ304_RS05720	COG0745	RESPONSE REGULATOR receiver
EZ304_RS05725	COG1381	Involved in DNA repair and RecF pathway recombination
EZ304_RS05730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EZ304_RS05745	COG0681	Belongs to the peptidase S26 family
EZ304_RS05750	COG0481	GTPase activity
EZ304_RS05755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZ304_RS05770	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZ304_RS05770	COG1024	Enoyl-CoA hydratase
EZ304_RS05775	COG1741	Belongs to the pirin family
EZ304_RS05780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EZ304_RS05790	COG1741	Belongs to the pirin family
EZ304_RS05800	COG1966	Carbon starvation protein
EZ304_RS05805	COG2879	small protein
EZ304_RS05820	COG2205	protein histidine kinase activity
EZ304_RS05825	COG0745	RESPONSE REGULATOR receiver
EZ304_RS05865	COG2814	Major facilitator Superfamily
EZ304_RS05870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZ304_RS05870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZ304_RS05880	COG1113	amino acid transport
EZ304_RS05885	COG2207	Transcriptional regulator
EZ304_RS05885	COG1917	Cupin 2, conserved barrel domain protein
EZ304_RS05905	COG0840	transmembrane signaling receptor activity
EZ304_RS05915	COG1376	ErfK ybiS ycfS ynhG family protein
EZ304_RS05920	COG0739	heme binding
EZ304_RS05930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EZ304_RS05940	COG0330	HflC and HflK could
EZ304_RS05945	COG0330	HflC and HflK could
EZ304_RS05950	COG0604	alcohol dehydrogenase
EZ304_RS05965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EZ304_RS05965	COG0678	peroxiredoxin activity
EZ304_RS05975	COG4953	penicillin-binding protein 1C
EZ304_RS05980	COG2373	Large extracellular alpha-helical protein
EZ304_RS05985	COG2079	MmgE PrpD family protein
EZ304_RS05990	COG2828	Protein conserved in bacteria
EZ304_RS06000	COG3609	addiction module antidote protein, CC2985 family
EZ304_RS06020	COG3829	transcription factor binding
EZ304_RS06035	COG0259	pyridoxamine-phosphate oxidase activity
EZ304_RS06050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EZ304_RS06070	COG0477	Major facilitator Superfamily
EZ304_RS06075	COG5002	protein histidine kinase activity
EZ304_RS06075	COG2198	Histidine kinase
EZ304_RS06075	COG0784	Response regulator, receiver
EZ304_RS06090	COG3038	cytochrome b561
EZ304_RS06105	COG1760	l-serine dehydratase
EZ304_RS06115	COG0527	aspartate kinase activity
EZ304_RS06115	COG0460	homoserine dehydrogenase
EZ304_RS06120	COG0626	cystathionine gamma-synthase activity
EZ304_RS06125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZ304_RS06130	COG0739	heme binding
EZ304_RS06135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EZ304_RS06140	COG1272	protein, Hemolysin III
EZ304_RS06155	COG0463	Glycosyl transferase, family 2
EZ304_RS06160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EZ304_RS06165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EZ304_RS06175	COG4206	TonB-dependent receptor
EZ304_RS06180	COG1309	transcriptional regulator
EZ304_RS06190	COG1960	acyl-CoA dehydrogenase activity
EZ304_RS06220	COG0583	DNA-binding transcription factor activity
EZ304_RS06235	COG0509	glycine decarboxylation via glycine cleavage system
EZ304_RS06240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EZ304_RS06250	COG0330	HflC and HflK could
EZ304_RS06260	COG1742	UPF0060 membrane protein
EZ304_RS06265	COG3956	TIGRFAM MazG family protein
EZ304_RS06270	COG1218	3'(2'),5'-bisphosphate nucleotidase
EZ304_RS06275	COG0494	nUDIX hydrolase
EZ304_RS06285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EZ304_RS06300	COG0784	Response regulator, receiver
EZ304_RS06300	COG2198	Histidine kinase
EZ304_RS06300	COG0643	Histidine kinase
EZ304_RS06305	COG0840	transmembrane signaling receptor activity
EZ304_RS06310	COG0835	chemotaxis
EZ304_RS06325	COG0189	ligase activity
EZ304_RS06335	COG1214	PFAM Peptidase M22, glycoprotease
EZ304_RS06340	COG1199	ATP-dependent helicase activity
EZ304_RS06355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EZ304_RS06360	COG1215	transferase activity, transferring glycosyl groups
EZ304_RS06375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EZ304_RS06385	COG1643	Atp-dependent helicase
EZ304_RS06390	COG0783	Belongs to the Dps family
EZ304_RS06395	COG0514	ATP-dependent DNA helicase (RecQ)
EZ304_RS06405	COG2132	Multicopper oxidase
EZ304_RS06465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EZ304_RS06470	COG0602	queuosine metabolic process
EZ304_RS06480	COG2885	chlorophyll binding
EZ304_RS06485	COG0823	Involved in the tonB-independent uptake of proteins
EZ304_RS06500	COG0811	peptide transport
EZ304_RS06505	COG0824	Thioesterase
EZ304_RS06510	COG2255	four-way junction helicase activity
EZ304_RS06520	COG0632	four-way junction helicase activity
EZ304_RS06525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EZ304_RS06530	COG0217	transcriptional regulatory protein
EZ304_RS06550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EZ304_RS06580	COG0488	(ABC) transporter
EZ304_RS06590	COG4651	solute:proton antiporter activity
EZ304_RS06590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZ304_RS06600	COG0745	RESPONSE REGULATOR receiver
EZ304_RS06605	COG2205	protein histidine kinase activity
EZ304_RS06615	COG0542	response to heat
EZ304_RS06640	COG0028	Belongs to the TPP enzyme family
EZ304_RS06665	COG3387	PFAM Glycoside hydrolase 15-related
EZ304_RS06670	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EZ304_RS06675	COG3011	Protein conserved in bacteria
EZ304_RS06690	COG0564	pseudouridine synthase activity
EZ304_RS06695	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZ304_RS06705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EZ304_RS06705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZ304_RS06715	COG0045	succinate-CoA ligase (ADP-forming) activity
EZ304_RS06750	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EZ304_RS06760	COG2205	protein histidine kinase activity
EZ304_RS06765	COG0745	RESPONSE REGULATOR receiver
EZ304_RS06780	COG0189	ligase activity
EZ304_RS06820	COG2022	thiamine diphosphate biosynthetic process
EZ304_RS06825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EZ304_RS06830	COG3273	potassium ion transport
EZ304_RS06830	COG0471	metal ion transport
EZ304_RS06850	COG1970	mechanosensitive ion channel activity
EZ304_RS06860	COG1115	amino acid carrier protein
EZ304_RS06870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZ304_RS06875	COG1115	amino acid carrier protein
EZ304_RS06880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZ304_RS06885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS06890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS06920	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EZ304_RS06930	COG3588	fructose-bisphosphate aldolase
EZ304_RS06935	COG0469	pyruvate kinase activity
EZ304_RS06945	COG0126	phosphoglycerate kinase activity
EZ304_RS06960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EZ304_RS07005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EZ304_RS07010	COG1301	dicarboxylic acid transport
EZ304_RS07040	COG0714	Associated with various cellular activities
EZ304_RS07070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EZ304_RS07140	COG0254	rRNA binding
EZ304_RS07150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EZ304_RS07160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EZ304_RS07165	COG1758	RNA polymerase activity
EZ304_RS07180	COG0437	4 iron, 4 sulfur cluster binding
EZ304_RS07185	COG2864	formate dehydrogenase
EZ304_RS07195	COG1921	L-seryl-tRNASec selenium transferase activity
EZ304_RS07200	COG3276	selenocysteine insertion sequence binding
EZ304_RS07210	COG0709	Synthesizes selenophosphate from selenide and ATP
EZ304_RS07215	COG1561	YicC-like family, N-terminal region
EZ304_RS07220	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EZ304_RS07225	COG0346	lactoylglutathione lyase activity
EZ304_RS07235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EZ304_RS07250	COG0006	proline dipeptidase activity
EZ304_RS07255	COG0006	proline dipeptidase activity
EZ304_RS07260	COG3079	Belongs to the UPF0149 family
EZ304_RS07280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EZ304_RS07290	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EZ304_RS07300	COG2912	Transglutaminase-like superfamily
EZ304_RS07305	COG1773	rubredoxin
EZ304_RS07310	COG0352	thiamine-phosphate diphosphorylase activity
EZ304_RS07315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EZ304_RS07330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZ304_RS07335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZ304_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS07360	COG0671	phosphoesterase, PA-phosphatase related
EZ304_RS07370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EZ304_RS07375	COG0563	adenylate kinase activity
EZ304_RS07395	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EZ304_RS07405	COG0848	biopolymer transport protein
EZ304_RS07415	COG2832	Protein of unknown function (DUF454)
EZ304_RS07445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EZ304_RS07470	COG0745	RESPONSE REGULATOR receiver
EZ304_RS07480	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EZ304_RS07485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EZ304_RS07490	COG0405	Gamma-glutamyltransferase
EZ304_RS07495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EZ304_RS07515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EZ304_RS07520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZ304_RS07535	COG0473	3-isopropylmalate dehydrogenase activity
EZ304_RS07550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS07555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS07570	COG1538	Outer membrane efflux protein
EZ304_RS07575	COG0531	amino acid
EZ304_RS07580	COG1519	Transferase
EZ304_RS07585	COG1560	Kdo2-lipid A biosynthetic process
EZ304_RS07625	COG1301	dicarboxylic acid transport
EZ304_RS07635	COG4191	Histidine kinase
EZ304_RS07650	COG0642	Histidine kinase
EZ304_RS07665	COG2851	Citrate transporter
EZ304_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS07695	COG1162	GTPase activity
EZ304_RS07700	COG0436	Aminotransferase
EZ304_RS07720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EZ304_RS07735	COG1228	amidohydrolase
EZ304_RS07740	COG0804	urea catabolic process
EZ304_RS07750	COG1307	EDD domain protein, DegV family
EZ304_RS07790	COG2203	Gaf domain
EZ304_RS07790	COG5001	Diguanylate cyclase
EZ304_RS07790	COG3706	GGDEF domain
EZ304_RS07790	COG4251	negative regulation of phosphorylation
EZ304_RS07795	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EZ304_RS07805	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EZ304_RS07820	COG1902	pentaerythritol trinitrate reductase activity
EZ304_RS07845	COG0583	DNA-binding transcription factor activity
EZ304_RS07850	COG1064	alcohol dehydrogenase
EZ304_RS07875	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EZ304_RS07880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EZ304_RS07895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EZ304_RS07910	COG1522	sequence-specific DNA binding
EZ304_RS07920	COG4773	Receptor
EZ304_RS07930	COG4206	TonB-dependent receptor
EZ304_RS07945	COG0617	tRNA 3'-terminal CCA addition
EZ304_RS07985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EZ304_RS07990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZ304_RS07995	COG1609	Transcriptional regulator
EZ304_RS08005	COG0837	glucose binding
EZ304_RS08015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EZ304_RS08035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EZ304_RS08045	COG4191	Histidine kinase
EZ304_RS08050	COG0784	Response regulator, receiver
EZ304_RS08055	COG4251	negative regulation of phosphorylation
EZ304_RS08060	COG2823	Periplasmic or secreted lipoprotein
EZ304_RS08065	COG0673	inositol 2-dehydrogenase activity
EZ304_RS08070	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EZ304_RS08090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EZ304_RS08095	COG0321	lipoyl(octanoyl) transferase activity
EZ304_RS08100	COG2921	Belongs to the UPF0250 family
EZ304_RS08110	COG1686	Belongs to the peptidase S11 family
EZ304_RS08115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EZ304_RS08120	COG2951	lytic endotransglycosylase activity
EZ304_RS08125	COG0772	Belongs to the SEDS family
EZ304_RS08130	COG0772	Belongs to the SEDS family
EZ304_RS08145	COG1792	Involved in formation and maintenance of cell shape
EZ304_RS08150	COG1077	Cell shape determining protein MreB Mrl
EZ304_RS08155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZ304_RS08160	COG0546	phosphoglycolate phosphatase activity
EZ304_RS08170	COG0308	aminopeptidase N
EZ304_RS08175	COG2226	methyltransferase
EZ304_RS08205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS08210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS08220	COG0673	inositol 2-dehydrogenase activity
EZ304_RS08230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EZ304_RS08250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EZ304_RS08260	COG2832	Protein of unknown function (DUF454)
EZ304_RS08270	COG0436	Aminotransferase
EZ304_RS08275	COG1505	serine-type exopeptidase activity
EZ304_RS08300	COG0697	spore germination
EZ304_RS08305	COG1666	GTP binding
EZ304_RS08335	COG0339	signal peptide processing
EZ304_RS08345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZ304_RS08365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZ304_RS08375	COG1136	(ABC) transporter
EZ304_RS08380	COG1136	(ABC) transporter
EZ304_RS08380	COG0577	efflux transmembrane transporter activity
EZ304_RS08385	COG0577	efflux transmembrane transporter activity
EZ304_RS08395	COG2204	response regulator
EZ304_RS08400	COG4191	Histidine kinase
EZ304_RS08410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EZ304_RS08420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EZ304_RS08425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EZ304_RS08430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EZ304_RS08435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EZ304_RS08440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EZ304_RS08445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EZ304_RS08455	COG0356	it plays a direct role in the translocation of protons across the membrane
EZ304_RS08470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZ304_RS08475	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZ304_RS08495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EZ304_RS08520	COG0181	hydroxymethylbilane synthase activity
EZ304_RS08530	COG0745	RESPONSE REGULATOR receiver
EZ304_RS08530	COG2972	Histidine kinase
EZ304_RS08550	COG4771	TonB-dependent receptor
EZ304_RS08585	COG0477	Major facilitator Superfamily
EZ304_RS08630	COG0625	glutathione transferase activity
EZ304_RS08645	COG2259	Doxx family
EZ304_RS08650	COG4977	sequence-specific DNA binding
EZ304_RS08670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZ304_RS08675	COG1490	D-aminoacyl-tRNA deacylase activity
EZ304_RS08725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EZ304_RS08725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZ304_RS08730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EZ304_RS08735	COG0242	peptide deformylase activity
EZ304_RS08745	COG0758	DNA mediated transformation
EZ304_RS08750	COG2922	Belongs to the Smg family
EZ304_RS08760	COG1714	RDD family
EZ304_RS08765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZ304_RS08765	COG1754	DNA topoisomerase type I activity
EZ304_RS08770	COG0009	L-threonylcarbamoyladenylate synthase
EZ304_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS08795	COG0616	signal peptide processing
EZ304_RS08800	COG0534	Mate efflux family protein
EZ304_RS08815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EZ304_RS08820	COG0625	glutathione transferase activity
EZ304_RS08830	COG1252	NADH dehydrogenase
EZ304_RS08860	COG2860	membrane
EZ304_RS08870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS08875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS08885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EZ304_RS08910	COG1846	Transcriptional regulator
EZ304_RS08915	COG5002	protein histidine kinase activity
EZ304_RS08940	COG0459	protein refolding
EZ304_RS08945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EZ304_RS08950	COG2356	endonuclease I
EZ304_RS08955	COG1324	tolerance protein
EZ304_RS08965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZ304_RS08980	COG0840	transmembrane signaling receptor activity
EZ304_RS09000	COG4585	Histidine kinase
EZ304_RS09030	COG3454	Phosphonate metabolism
EZ304_RS09035	COG2188	Transcriptional regulator
EZ304_RS09050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZ304_RS09055	COG0583	DNA-binding transcription factor activity
EZ304_RS09065	COG1785	Belongs to the alkaline phosphatase family
EZ304_RS09070	COG1686	Belongs to the peptidase S11 family
EZ304_RS09080	COG2249	NAD(P)H dehydrogenase (quinone) activity
EZ304_RS09100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EZ304_RS09110	COG0511	ligase activity, forming carbon-carbon bonds
EZ304_RS09115	COG0439	Biotin carboxylase
EZ304_RS09130	COG2264	protein methyltransferase activity
EZ304_RS09140	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EZ304_RS09145	COG4589	Belongs to the CDS family
EZ304_RS09150	COG0204	Acyl-transferase
EZ304_RS09160	COG2453	phosphatase
EZ304_RS09160	COG0671	phosphoesterase, PA-phosphatase related
EZ304_RS09165	COG2267	carboxylic ester hydrolase activity
EZ304_RS09170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EZ304_RS09175	COG0138	bifunctional purine biosynthesis protein purh
EZ304_RS09185	COG0151	Belongs to the GarS family
EZ304_RS09200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZ304_RS09215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZ304_RS09220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EZ304_RS09225	COG2201	protein-glutamate methylesterase activity
EZ304_RS09230	COG2177	Part of the ABC transporter FtsEX involved in
EZ304_RS09235	COG2884	Cell division ATP-binding protein ftsE
EZ304_RS09250	COG3118	belongs to the thioredoxin family
EZ304_RS09255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EZ304_RS09260	COG3706	GGDEF domain
EZ304_RS09270	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EZ304_RS09310	COG1652	LysM domain
EZ304_RS09315	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EZ304_RS09315	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EZ304_RS09320	COG1473	amidohydrolase
EZ304_RS09325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS09330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS09335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS09340	COG1289	transmembrane transporter activity
EZ304_RS09345	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS09350	COG2814	Major facilitator Superfamily
EZ304_RS09380	COG0316	Belongs to the HesB IscA family
EZ304_RS09405	COG5002	protein histidine kinase activity
EZ304_RS09405	COG0784	Response regulator, receiver
EZ304_RS09405	COG2205	protein histidine kinase activity
EZ304_RS09420	COG1051	belongs to the nudix hydrolase family
EZ304_RS09435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EZ304_RS09440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EZ304_RS09445	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EZ304_RS09455	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EZ304_RS09460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZ304_RS09465	COG0730	response to heat
EZ304_RS09475	COG0134	indole-3-glycerol-phosphate synthase activity
EZ304_RS09480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EZ304_RS09500	COG1597	lipid kinase activity
EZ304_RS09515	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EZ304_RS09520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EZ304_RS09530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EZ304_RS09530	COG2111	Na H antiporter
EZ304_RS09535	COG1006	Multisubunit Na H antiporter MnhC subunit
EZ304_RS09540	COG0651	ATP synthesis coupled electron transport
EZ304_RS09545	COG1863	multisubunit Na H antiporter MnhE subunit
EZ304_RS09550	COG2212	antiporter activity
EZ304_RS09555	COG1320	monovalent cation:proton antiporter activity
EZ304_RS09560	COG0530	calcium, potassium:sodium antiporter activity
EZ304_RS09585	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EZ304_RS09610	COG3104	oligopeptide transport
EZ304_RS09615	COG3483	tryptophan 2,3-dioxygenase activity
EZ304_RS09620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EZ304_RS09645	COG2378	regulation of single-species biofilm formation
EZ304_RS09660	COG2354	Protein conserved in bacteria
EZ304_RS09670	COG1368	sulfuric ester hydrolase activity
EZ304_RS09675	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EZ304_RS09675	COG3264	Mechanosensitive ion channel
EZ304_RS09690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EZ304_RS09690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZ304_RS09725	COG1166	arginine decarboxylase activity
EZ304_RS09730	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EZ304_RS09750	COG2960	long-chain fatty acid transporting porin activity
EZ304_RS09800	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EZ304_RS09820	COG5002	protein histidine kinase activity
EZ304_RS09980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZ304_RS09990	COG0431	NADPH-dependent FMN reductase
EZ304_RS09995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EZ304_RS10080	COG0561	phosphatase activity
EZ304_RS10085	COG3932	Exopolysaccharide synthesis, ExoD
EZ304_RS10115	COG1999	signal sequence binding
EZ304_RS10120	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EZ304_RS10125	COG1845	cytochrome c oxidase, subunit III
EZ304_RS10135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EZ304_RS10140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZ304_RS10155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZ304_RS10205	COG2031	fatty acid transporter
EZ304_RS10225	COG0673	inositol 2-dehydrogenase activity
EZ304_RS10235	COG1501	Belongs to the glycosyl hydrolase 31 family
EZ304_RS10240	COG2222	sugar isomerase
EZ304_RS10245	COG1940	carbohydrate kinase activity
EZ304_RS10255	COG1349	DNA-binding transcription factor activity
EZ304_RS10260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EZ304_RS10265	COG2814	Major facilitator Superfamily
EZ304_RS10280	COG1040	competence protein
EZ304_RS10290	COG3209	COG3209 Rhs family protein
EZ304_RS10310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EZ304_RS10315	COG0156	8-amino-7-oxononanoate synthase activity
EZ304_RS10320	COG2267	carboxylic ester hydrolase activity
EZ304_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS10340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EZ304_RS10365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS10370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS10375	COG2205	protein histidine kinase activity
EZ304_RS10380	COG0745	RESPONSE REGULATOR receiver
EZ304_RS10385	COG3541	Predicted nucleotidyltransferase
EZ304_RS10390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EZ304_RS10415	COG0714	Associated with various cellular activities
EZ304_RS10430	COG0754	glutathionylspermidine amidase activity
EZ304_RS10445	COG0129	dihydroxy-acid dehydratase activity
EZ304_RS10450	COG2311	Membrane
EZ304_RS10455	COG1199	ATP-dependent helicase activity
EZ304_RS10465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EZ304_RS10485	COG3781	membrane
EZ304_RS10515	COG0625	glutathione transferase activity
EZ304_RS10535	COG2207	Transcriptional regulator
EZ304_RS10550	COG4555	ABC transporter
EZ304_RS10580	COG0633	Ferredoxin
EZ304_RS10580	COG0543	2 iron, 2 sulfur cluster binding
EZ304_RS10585	COG1131	(ABC) transporter
EZ304_RS10590	COG0842	Transport permease protein
EZ304_RS10600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EZ304_RS10610	COG0084	hydrolase, TatD family'
EZ304_RS10615	COG1643	Atp-dependent helicase
EZ304_RS10625	COG1187	pseudouridine synthase activity
EZ304_RS10640	COG0667	Aldo Keto reductase
EZ304_RS10655	COG1690	Belongs to the RtcB family
EZ304_RS10665	COG1959	2 iron, 2 sulfur cluster binding
EZ304_RS10670	COG0840	transmembrane signaling receptor activity
EZ304_RS10675	COG0583	DNA-binding transcription factor activity
EZ304_RS10680	COG2814	Major facilitator Superfamily
EZ304_RS10685	COG0656	L-ascorbic acid biosynthetic process
EZ304_RS10690	COG2267	carboxylic ester hydrolase activity
EZ304_RS10695	COG0393	Putative heavy-metal-binding
EZ304_RS10700	COG1042	CoA-binding domain protein
EZ304_RS10700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZ304_RS10700	COG0045	succinate-CoA ligase (ADP-forming) activity
EZ304_RS10705	COG2239	Acts as a magnesium transporter
EZ304_RS10720	COG3177	Filamentation induced by cAMP protein fic
EZ304_RS10720	COG0666	response to abiotic stimulus
EZ304_RS10725	COG3100	YcgL domain-containing protein
EZ304_RS10735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZ304_RS10740	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS10760	COG0644	oxidoreductase
EZ304_RS10780	COG2986	histidine ammonia-lyase
EZ304_RS10790	COG0463	Glycosyl transferase, family 2
EZ304_RS10795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZ304_RS10805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZ304_RS10810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZ304_RS10825	COG1294	oxidase, subunit
EZ304_RS10830	COG1271	oxidase subunit
EZ304_RS10865	COG1595	DNA-templated transcription, initiation
EZ304_RS10900	COG0408	coproporphyrinogen oxidase activity
EZ304_RS10910	COG2323	membrane
EZ304_RS10935	COG0589	response to stress
EZ304_RS10960	COG0210	DNA helicase
EZ304_RS10970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EZ304_RS10975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EZ304_RS10980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EZ304_RS10995	COG0251	oxidation-reduction process
EZ304_RS11030	COG0463	Glycosyl transferase, family 2
EZ304_RS11045	COG1475	DNA binding
EZ304_RS11050	COG1192	Involved in chromosome partitioning
EZ304_RS11055	COG0357	Ribosomal RNA small subunit methyltransferase G
EZ304_RS11060	COG2091	lysine biosynthetic process via aminoadipic acid
EZ304_RS11100	COG1971	Probably functions as a manganese efflux pump
EZ304_RS11105	COG0784	Response regulator, receiver
EZ304_RS11105	COG2205	protein histidine kinase activity
EZ304_RS11115	COG0443	Heat shock 70 kDa protein
EZ304_RS11130	COG2911	Protein conserved in bacteria
EZ304_RS11135	COG0729	surface antigen
EZ304_RS11145	COG0752	glycyl-tRNA synthetase alpha subunit
EZ304_RS11150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZ304_RS11155	COG0519	Catalyzes the synthesis of GMP from XMP
EZ304_RS11155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZ304_RS11165	COG0805	protein transport
EZ304_RS11175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZ304_RS11185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EZ304_RS11190	COG0596	Alpha beta hydrolase
EZ304_RS11190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EZ304_RS11195	COG0840	transmembrane signaling receptor activity
EZ304_RS11215	COG4942	peptidase
EZ304_RS11220	COG0793	Belongs to the peptidase S41A family
EZ304_RS11250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EZ304_RS11295	COG0109	protoheme IX farnesyltransferase activity
EZ304_RS11315	COG0358	DNA primase activity
EZ304_RS11320	COG1295	ribonuclease BN
EZ304_RS11335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EZ304_RS11345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EZ304_RS11350	COG0668	transmembrane transport
EZ304_RS11365	COG2133	pyrroloquinoline quinone binding
EZ304_RS11370	COG4682	membrane
EZ304_RS11380	COG0531	amino acid
EZ304_RS11390	COG1737	Transcriptional regulator
EZ304_RS11395	COG4948	Mandelate Racemase Muconate Lactonizing
EZ304_RS11445	COG5383	Protein conserved in bacteria
EZ304_RS11455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EZ304_RS11460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EZ304_RS11490	COG0778	Nitroreductase
EZ304_RS11495	COG2353	YceI-like domain
EZ304_RS11510	COG2375	cellular response to nickel ion
EZ304_RS11525	COG2131	deaminase
EZ304_RS11605	COG2267	carboxylic ester hydrolase activity
EZ304_RS11665	COG0488	(ABC) transporter
EZ304_RS11670	COG0583	DNA-binding transcription factor activity
EZ304_RS11680	COG2814	Major facilitator Superfamily
EZ304_RS11685	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EZ304_RS11690	COG1113	amino acid transport
EZ304_RS11695	COG0741	lytic transglycosylase activity
EZ304_RS11710	COG3795	YCII-related domain
EZ304_RS11720	COG2764	glyoxalase bleomycin resistance protein dioxygenase
EZ304_RS11730	COG5507	3-demethylubiquinone-9 3-methyltransferase
EZ304_RS11735	COG4941	Belongs to the sigma-70 factor family
EZ304_RS11765	COG3275	phosphorelay sensor kinase activity
EZ304_RS11770	COG3279	Response regulator of the LytR AlgR family
EZ304_RS11785	COG1309	transcriptional regulator
EZ304_RS11795	COG2814	Major facilitator Superfamily
EZ304_RS11800	COG3590	peptidase
EZ304_RS11805	COG5001	Diguanylate cyclase
EZ304_RS11810	COG0583	DNA-binding transcription factor activity
EZ304_RS11820	COG3384	dioxygenase
EZ304_RS11825	COG0025	NhaP-type Na H and K H
EZ304_RS11850	COG1360	Flagellar Motor Protein
EZ304_RS11880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZ304_RS11895	COG5002	protein histidine kinase activity
EZ304_RS11910	COG2813	Specifically methylates the guanine in position
EZ304_RS11915	COG1187	pseudouridine synthase activity
EZ304_RS11920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZ304_RS11930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZ304_RS11935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EZ304_RS11955	COG0583	DNA-binding transcription factor activity
EZ304_RS11960	COG2226	methyltransferase
EZ304_RS11985	COG1956	GAF domain-containing protein
EZ304_RS11990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EZ304_RS11995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZ304_RS12000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZ304_RS12005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZ304_RS12005	COG0785	Cytochrome C biogenesis protein
EZ304_RS12010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZ304_RS12015	COG0745	RESPONSE REGULATOR receiver
EZ304_RS12020	COG5002	protein histidine kinase activity
EZ304_RS12025	COG2205	protein histidine kinase activity
EZ304_RS12030	COG0745	RESPONSE REGULATOR receiver
EZ304_RS12035	COG0367	asparagine synthase
EZ304_RS12045	COG0720	synthase
EZ304_RS12060	COG0513	Belongs to the DEAD box helicase family
EZ304_RS12070	COG0625	glutathione transferase activity
EZ304_RS12100	COG0626	cystathionine gamma-synthase activity
EZ304_RS12125	COG1215	transferase activity, transferring glycosyl groups
EZ304_RS12130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EZ304_RS12145	COG0300	oxidoreductase activity
EZ304_RS12150	COG0277	FAD linked oxidase domain protein
EZ304_RS12155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EZ304_RS12155	COG0546	phosphoglycolate phosphatase activity
EZ304_RS12170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZ304_RS12200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZ304_RS12205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZ304_RS12265	COG1127	ABC transporter
EZ304_RS12270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EZ304_RS12285	COG0442	prolyl-tRNA aminoacylation
EZ304_RS12295	COG1183	phosphatidylcholine synthase activity
EZ304_RS12305	COG0456	acetyltransferase
EZ304_RS12315	COG0525	valine-tRNA ligase activity
EZ304_RS12330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZ304_RS12340	COG0795	lipopolysaccharide-transporting ATPase activity
EZ304_RS12350	COG4974	Belongs to the 'phage' integrase family
EZ304_RS12365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZ304_RS12365	COG0047	phosphoribosylformylglycinamidine synthase activity
EZ304_RS12370	COG5295	Hep Hag repeat protein
EZ304_RS12375	COG1404	Belongs to the peptidase S8 family
EZ304_RS12380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZ304_RS12385	COG1459	type II secretion system
EZ304_RS12390	COG2165	general secretion pathway protein
EZ304_RS12395	COG4970	Tfp pilus assembly protein FimT
EZ304_RS12405	COG4795	General secretion pathway protein
EZ304_RS12410	COG3156	type II secretion system protein K
EZ304_RS12415	COG3166	PFAM Fimbrial assembly family protein
EZ304_RS12430	COG1450	Type ii and iii secretion system protein
EZ304_RS12460	COG3539	Fimbrial protein
EZ304_RS12465	COG3121	Chaperone
EZ304_RS12490	COG2194	sulfuric ester hydrolase activity
EZ304_RS12505	COG1215	transferase activity, transferring glycosyl groups
EZ304_RS12515	COG0457	Tetratricopeptide repeat
EZ304_RS12515	COG3118	belongs to the thioredoxin family
EZ304_RS12520	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EZ304_RS12525	COG2252	PERMEase
EZ304_RS12530	COG0488	(ABC) transporter
EZ304_RS12540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZ304_RS12560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EZ304_RS12565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZ304_RS12565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZ304_RS12600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EZ304_RS12605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZ304_RS12620	COG3121	Chaperone
EZ304_RS12630	COG3188	usher protein
EZ304_RS12645	COG0277	FAD linked oxidase domain protein
EZ304_RS12650	COG1988	membrane-bound metal-dependent
EZ304_RS12685	COG2001	Belongs to the MraZ family
EZ304_RS12690	COG0275	rRNA processing
EZ304_RS12695	COG3116	cell division
EZ304_RS12710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EZ304_RS12730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EZ304_RS12735	COG1181	Belongs to the D-alanine--D-alanine ligase family
EZ304_RS12740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EZ304_RS12750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EZ304_RS12755	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EZ304_RS12765	COG0739	heme binding
EZ304_RS12770	COG0653	protein targeting
EZ304_RS12775	COG0494	nUDIX hydrolase
EZ304_RS12785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EZ304_RS12795	COG3275	phosphorelay sensor kinase activity
EZ304_RS12800	COG3279	Response regulator of the LytR AlgR family
EZ304_RS12810	COG5002	protein histidine kinase activity
EZ304_RS12810	COG3850	Histidine kinase
EZ304_RS12840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EZ304_RS12845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EZ304_RS12860	COG1607	acyl-coa hydrolase
EZ304_RS12865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EZ304_RS12895	COG4106	trans-aconitate 2-methyltransferase activity
EZ304_RS12900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZ304_RS12920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZ304_RS12925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EZ304_RS12930	COG0667	Aldo Keto reductase
EZ304_RS12940	COG4771	TonB-dependent receptor
EZ304_RS12965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EZ304_RS12970	COG4181	ATPase activity
EZ304_RS12985	COG0642	Histidine kinase
EZ304_RS12995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EZ304_RS13000	COG0861	Integral membrane protein TerC family
EZ304_RS13005	COG2814	Major facilitator Superfamily
EZ304_RS13010	COG1704	LemA family
EZ304_RS13025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EZ304_RS13030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EZ304_RS13040	COG3738	Protein conserved in bacteria
EZ304_RS13045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EZ304_RS13050	COG2967	ApaG domain
EZ304_RS13055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EZ304_RS13060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EZ304_RS13065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZ304_RS13070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EZ304_RS13080	COG2096	Adenosyltransferase
EZ304_RS13090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZ304_RS13095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZ304_RS13100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EZ304_RS13105	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EZ304_RS13125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZ304_RS13135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZ304_RS13145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZ304_RS13150	COG0583	DNA-binding transcription factor activity
EZ304_RS13155	COG3634	alkyl hydroperoxide reductase activity
EZ304_RS13175	COG0583	DNA-binding transcription factor activity
EZ304_RS13215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EZ304_RS13240	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EZ304_RS13255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZ304_RS13275	COG1404	Belongs to the peptidase S8 family
EZ304_RS13295	COG1295	ribonuclease BN
EZ304_RS13300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZ304_RS13315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EZ304_RS13320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EZ304_RS13335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EZ304_RS13345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EZ304_RS13350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EZ304_RS13355	COG0193	aminoacyl-tRNA hydrolase activity
EZ304_RS13360	COG0012	GTP binding
EZ304_RS13365	COG4206	TonB-dependent receptor
EZ304_RS13370	COG4242	Belongs to the peptidase S51 family
EZ304_RS13395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZ304_RS13410	COG0250	Participates in transcription elongation, termination and antitermination
EZ304_RS13415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EZ304_RS13420	COG0081	regulation of translation
EZ304_RS13430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EZ304_RS13435	COG0222	ribosome binding
EZ304_RS13440	COG0085	RNA polymerase activity
EZ304_RS13445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EZ304_RS13450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EZ304_RS13455	COG0049	tRNA binding
EZ304_RS13460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EZ304_RS13465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZ304_RS13470	COG0051	transcription antitermination factor activity, RNA binding
EZ304_RS13475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EZ304_RS13480	COG0088	Forms part of the polypeptide exit tunnel
EZ304_RS13485	COG0089	rRNA binding
EZ304_RS13490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EZ304_RS13495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EZ304_RS13500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EZ304_RS13505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EZ304_RS13510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EZ304_RS13515	COG0255	Belongs to the universal ribosomal protein uL29 family
EZ304_RS13520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EZ304_RS13525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EZ304_RS13530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EZ304_RS13535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EZ304_RS13540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EZ304_RS13550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EZ304_RS13555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EZ304_RS13560	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EZ304_RS13565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EZ304_RS13570	COG1841	ribosomal large subunit assembly
EZ304_RS13575	COG0200	Binds to the 23S rRNA
EZ304_RS13580	COG0201	protein transport
EZ304_RS13585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EZ304_RS13590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EZ304_RS13595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EZ304_RS13600	COG0202	RNA polymerase activity
EZ304_RS13605	COG0203	ribosomal protein L17
EZ304_RS13620	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EZ304_RS13640	COG0154	amidase activity
EZ304_RS13655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EZ304_RS13660	COG0039	L-malate dehydrogenase activity
EZ304_RS13665	COG0564	pseudouridine synthase activity
EZ304_RS13680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZ304_RS13695	COG0625	glutathione transferase activity
EZ304_RS13705	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZ304_RS13705	COG1902	pentaerythritol trinitrate reductase activity
EZ304_RS13710	COG2364	Membrane
EZ304_RS13715	COG0604	alcohol dehydrogenase
EZ304_RS13730	COG1187	pseudouridine synthase activity
EZ304_RS13750	COG1063	alcohol dehydrogenase
EZ304_RS13760	COG0588	phosphoglycerate mutase activity
EZ304_RS13765	COG0285	dihydrofolate synthase activity
EZ304_RS13785	COG2833	Protein of unknown function (DUF455)
EZ304_RS13795	COG3291	Pkd domain containing protein
EZ304_RS13800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZ304_RS13810	COG0438	transferase activity, transferring glycosyl groups
EZ304_RS13815	COG4771	TonB-dependent receptor
EZ304_RS13820	COG4206	TonB-dependent receptor
EZ304_RS13825	COG0248	Ppx GppA phosphatase
EZ304_RS13830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EZ304_RS13845	COG4783	chaperone-mediated protein folding
EZ304_RS13860	COG0473	3-isopropylmalate dehydrogenase activity
EZ304_RS13870	COG0583	DNA-binding transcription factor activity
EZ304_RS13920	COG0544	peptidyl-prolyl cis-trans isomerase activity
EZ304_RS13925	COG0740	serine-type endopeptidase activity
EZ304_RS13930	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EZ304_RS13970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZ304_RS13975	COG1388	LysM domain
EZ304_RS13975	COG3942	CHAP domain
EZ304_RS13980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZ304_RS13985	COG2226	methyltransferase
EZ304_RS13990	COG0328	RNA-DNA hybrid ribonuclease activity
EZ304_RS13995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EZ304_RS14000	COG0631	protein serine/threonine phosphatase activity
EZ304_RS14020	COG0859	PFAM glycosyl transferase family 9
EZ304_RS14025	COG3642	lipopolysaccharide core region biosynthetic process
EZ304_RS14030	COG1234	tRNA 3'-trailer cleavage
EZ304_RS14045	COG2076	Multidrug Resistance protein
EZ304_RS14070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EZ304_RS14075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EZ304_RS14085	COG0537	adenosine 5'-monophosphoramidase activity
EZ304_RS14105	COG0714	Associated with various cellular activities
EZ304_RS14120	COG1399	metal-binding, possibly nucleic acid-binding protein
EZ304_RS14125	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EZ304_RS14130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZ304_RS14140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EZ304_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS14155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZ304_RS14160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EZ304_RS14165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EZ304_RS14170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EZ304_RS14330	COG4774	siderophore transport
EZ304_RS14345	COG2223	nitrite transmembrane transporter activity
EZ304_RS14360	COG2226	methyltransferase
EZ304_RS14370	COG0583	DNA-binding transcription factor activity
EZ304_RS14375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZ304_RS14380	COG0697	spore germination
EZ304_RS14385	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS14400	COG0477	Major facilitator Superfamily
EZ304_RS14410	COG2205	protein histidine kinase activity
EZ304_RS14420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS14460	COG0583	DNA-binding transcription factor activity
EZ304_RS14470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EZ304_RS14485	COG0667	Aldo Keto reductase
EZ304_RS14510	COG2818	Glycosylase
EZ304_RS14515	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EZ304_RS14520	COG1678	Uncharacterized ACR, COG1678
EZ304_RS14525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EZ304_RS14530	COG0540	Belongs to the ATCase OTCase family
EZ304_RS14550	COG2239	Acts as a magnesium transporter
EZ304_RS14555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EZ304_RS14570	COG1660	Displays ATPase and GTPase activities
EZ304_RS14575	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EZ304_RS14580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZ304_RS14585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EZ304_RS14595	COG1137	ATPase activity
EZ304_RS14610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EZ304_RS14625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EZ304_RS14645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EZ304_RS14665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EZ304_RS14675	COG0628	permease
EZ304_RS14685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EZ304_RS14690	COG3178	'Phosphotransferase
EZ304_RS14695	COG2261	transglycosylase associated protein
EZ304_RS14705	COG1555	photosystem II stabilization
EZ304_RS14725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EZ304_RS14730	COG1477	protein flavinylation
EZ304_RS14750	COG4771	TonB-dependent receptor
EZ304_RS14760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EZ304_RS14765	COG3128	pkhd-type hydroxylase
EZ304_RS14775	COG4774	siderophore transport
EZ304_RS14785	COG2146	nitrite reductase [NAD(P)H] activity
EZ304_RS14795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZ304_RS14800	COG0719	Fe-S assembly protein
EZ304_RS14805	COG0396	ATPase activity
EZ304_RS14815	COG0719	Fe-S assembly protein
EZ304_RS14820	COG1959	2 iron, 2 sulfur cluster binding
EZ304_RS14850	COG1764	response to oxidative stress
EZ304_RS14855	COG0384	phenazine biosynthesis protein PhzF
EZ304_RS14860	COG0384	phenazine biosynthesis protein PhzF
EZ304_RS14865	COG0527	aspartate kinase activity
EZ304_RS14875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EZ304_RS14890	COG0142	geranyltranstransferase activity
EZ304_RS14895	COG0366	Alpha amylase catalytic
EZ304_RS14905	COG1082	Xylose isomerase domain protein TIM barrel
EZ304_RS14915	COG2190	(PTS) system
EZ304_RS14915	COG2211	Major facilitator Superfamily
EZ304_RS14950	COG1131	(ABC) transporter
EZ304_RS14965	COG0629	single-stranded DNA binding
EZ304_RS14990	COG2010	Cytochrome c
EZ304_RS15000	COG0673	inositol 2-dehydrogenase activity
EZ304_RS15005	COG2211	Major facilitator Superfamily
EZ304_RS15015	COG1609	Transcriptional regulator
EZ304_RS15065	COG0640	Transcriptional regulator
EZ304_RS15080	COG3655	Transcriptional regulator
EZ304_RS15085	COG1253	flavin adenine dinucleotide binding
EZ304_RS15090	COG1408	metallophosphoesterase
EZ304_RS15120	COG1802	Transcriptional regulator
EZ304_RS15155	COG3052	prosthetic group binding
EZ304_RS15170	COG0579	oxidoreductase
EZ304_RS15195	COG3104	oligopeptide transport
EZ304_RS15210	COG1297	OPT oligopeptide transporter protein
EZ304_RS15215	COG1506	peptidase
EZ304_RS15215	COG0823	Involved in the tonB-independent uptake of proteins
EZ304_RS15230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EZ304_RS15235	COG2894	cell division
EZ304_RS15250	COG4585	Histidine kinase
EZ304_RS15255	COG2197	response regulator
EZ304_RS15295	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EZ304_RS15305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EZ304_RS15315	COG1595	DNA-templated transcription, initiation
EZ304_RS15325	COG1946	Acyl-CoA thioesterase
EZ304_RS15345	COG0824	Thioesterase
EZ304_RS15350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EZ304_RS15355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EZ304_RS15360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EZ304_RS15365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EZ304_RS15370	COG0268	Binds directly to 16S ribosomal RNA
EZ304_RS15375	COG0728	peptidoglycan biosynthetic process
EZ304_RS15380	COG0196	riboflavin kinase activity
EZ304_RS15385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EZ304_RS15395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EZ304_RS15420	COG4206	TonB-dependent receptor
EZ304_RS15440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZ304_RS15490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EZ304_RS15495	COG1845	cytochrome c oxidase, subunit III
EZ304_RS15500	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EZ304_RS15515	COG0326	Molecular chaperone. Has ATPase activity
EZ304_RS15535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EZ304_RS15550	COG0228	four-way junction DNA binding
EZ304_RS15555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EZ304_RS15560	COG0336	Belongs to the RNA methyltransferase TrmD family
EZ304_RS15565	COG0335	large ribosomal subunit rRNA binding
EZ304_RS15585	COG0534	Mate efflux family protein
EZ304_RS15610	COG0753	catalase activity
EZ304_RS15640	COG0840	transmembrane signaling receptor activity
EZ304_RS15660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS15680	COG0024	Methionine aminopeptidase
EZ304_RS15705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EZ304_RS15730	COG1647	Serine aminopeptidase, S33
EZ304_RS15755	COG2814	Major facilitator Superfamily
EZ304_RS15760	COG3706	GGDEF domain
EZ304_RS15780	COG0588	phosphoglycerate mutase activity
EZ304_RS15785	COG3590	peptidase
EZ304_RS15795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EZ304_RS15805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EZ304_RS15810	COG0745	RESPONSE REGULATOR receiver
EZ304_RS15815	COG2205	protein histidine kinase activity
EZ304_RS15820	COG4452	Inner membrane protein CreD
EZ304_RS15835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZ304_RS15840	COG0735	belongs to the Fur family
EZ304_RS15880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZ304_RS15930	COG5001	Diguanylate cyclase
EZ304_RS15930	COG5002	protein histidine kinase activity
EZ304_RS15940	COG1187	pseudouridine synthase activity
EZ304_RS15950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZ304_RS15970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EZ304_RS16025	COG1695	Transcriptional regulator
EZ304_RS16045	COG1981	membrane
EZ304_RS16050	COG0825	malonyl-CoA metabolic process
EZ304_RS16075	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZ304_RS16085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZ304_RS16090	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZ304_RS16095	COG0750	zinc metalloprotease
EZ304_RS16100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EZ304_RS16105	COG0575	Belongs to the CDS family
EZ304_RS16110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EZ304_RS16115	COG0233	cytoplasmic translational termination
EZ304_RS16120	COG0528	UMP kinase activity
EZ304_RS16125	COG5001	Diguanylate cyclase
EZ304_RS16130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EZ304_RS16135	COG0052	Belongs to the universal ribosomal protein uS2 family
EZ304_RS16155	COG3188	usher protein
EZ304_RS16175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EZ304_RS16190	COG1393	Belongs to the ArsC family
EZ304_RS16195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZ304_RS16205	COG0367	asparagine synthase
EZ304_RS16210	COG0475	glutathione-regulated potassium exporter activity
EZ304_RS16245	COG1566	PFAM secretion protein HlyD family protein
EZ304_RS16250	COG2814	Major facilitator Superfamily
EZ304_RS16260	COG0583	DNA-binding transcription factor activity
EZ304_RS16280	COG0557	exoribonuclease II activity
EZ304_RS16290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZ304_RS16295	COG1538	Outer membrane efflux protein
EZ304_RS16300	COG1136	(ABC) transporter
EZ304_RS16300	COG0577	efflux transmembrane transporter activity
EZ304_RS16305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS16325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EZ304_RS16330	COG2259	Doxx family
EZ304_RS16340	COG3220	belongs to the UPF0276 family
EZ304_RS16350	COG0704	Plays a role in the regulation of phosphate uptake
EZ304_RS16360	COG0581	inorganic phosphate transmembrane transporter activity
EZ304_RS16365	COG0573	inorganic phosphate transmembrane transporter activity
EZ304_RS16370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EZ304_RS16375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EZ304_RS16385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EZ304_RS16395	COG1024	Enoyl-CoA hydratase
EZ304_RS16405	COG0494	nUDIX hydrolase
EZ304_RS16425	COG0116	Belongs to the methyltransferase superfamily
EZ304_RS16425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EZ304_RS16450	COG2733	membrane
EZ304_RS16460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZ304_RS16465	COG1012	belongs to the aldehyde dehydrogenase family
EZ304_RS16475	COG0477	Major facilitator Superfamily
EZ304_RS16480	COG2703	oxygen carrier activity
EZ304_RS16500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZ304_RS16505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EZ304_RS16510	COG0174	glutamine synthetase
EZ304_RS16520	COG2072	flavoprotein involved in K transport
EZ304_RS16525	COG3842	ATPase activity
EZ304_RS16530	COG1176	ABC-type spermidine putrescine transport system, permease component I
EZ304_RS16535	COG1177	transmembrane transport
EZ304_RS16540	COG1012	belongs to the aldehyde dehydrogenase family
EZ304_RS16555	COG4535	Mg2 and Co2 transporter CorC
EZ304_RS16575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EZ304_RS16580	COG1702	phosphate starvation-inducible protein PhoH
EZ304_RS16590	COG1131	(ABC) transporter
EZ304_RS16595	COG0842	Transport permease protein
EZ304_RS16600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZ304_RS16615	COG0741	lytic transglycosylase activity
EZ304_RS16620	COG0723	plastoquinol--plastocyanin reductase activity
EZ304_RS16625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EZ304_RS16630	COG2857	Cytochrome c1
EZ304_RS16635	COG0625	glutathione transferase activity
EZ304_RS16640	COG2969	positive regulation of protein catabolic process
EZ304_RS16675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EZ304_RS16685	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EZ304_RS16710	COG1611	Belongs to the LOG family
EZ304_RS16755	COG0556	nucleotide-excision repair
EZ304_RS16790	COG3713	MltA-interacting MipA family protein
EZ304_RS16810	COG0811	peptide transport
EZ304_RS16825	COG1663	tetraacyldisaccharide 4'-kinase activity
EZ304_RS16830	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EZ304_RS16835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZ304_RS16845	COG0322	excinuclease ABC activity
EZ304_RS16885	COG0577	efflux transmembrane transporter activity
EZ304_RS16885	COG1136	(ABC) transporter
EZ304_RS16960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EZ304_RS17000	COG0583	DNA-binding transcription factor activity
EZ304_RS17020	COG4977	sequence-specific DNA binding
EZ304_RS17020	COG1917	Cupin 2, conserved barrel domain protein
EZ304_RS17025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EZ304_RS17060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EZ304_RS17075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EZ304_RS17080	COG0069	glutamate synthase activity
EZ304_RS17105	COG1054	Belongs to the UPF0176 family
EZ304_RS17110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZ304_RS17125	COG1253	flavin adenine dinucleotide binding
EZ304_RS17145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZ304_RS17160	COG0504	CTP synthase activity
EZ304_RS17165	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EZ304_RS17180	COG0148	phosphopyruvate hydratase activity
EZ304_RS17185	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EZ304_RS17190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EZ304_RS17195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EZ304_RS17205	COG2840	Smr protein MutS2
EZ304_RS17210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EZ304_RS17215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZ304_RS17240	COG1534	Rna-binding protein
EZ304_RS17245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EZ304_RS17250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZ304_RS17260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EZ304_RS17265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EZ304_RS17270	COG1923	regulation of RNA biosynthetic process
EZ304_RS17275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EZ304_RS17280	COG1546	Belongs to the CinA family
EZ304_RS17285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZ304_RS17290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EZ304_RS17295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EZ304_RS17300	COG2137	regulation of response to DNA damage stimulus
EZ304_RS17305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EZ304_RS17310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EZ304_RS17330	COG4773	Receptor
EZ304_RS17385	COG3540	Alkaline phosphatase
EZ304_RS17400	COG3258	Cytochrome c
EZ304_RS17415	COG2223	nitrite transmembrane transporter activity
EZ304_RS17430	COG1741	Belongs to the pirin family
EZ304_RS17435	COG0583	DNA-binding transcription factor activity
EZ304_RS17465	COG0351	phosphomethylpyrimidine kinase
EZ304_RS17465	COG0352	thiamine-phosphate diphosphorylase activity
EZ304_RS17480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EZ304_RS17485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EZ304_RS17495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZ304_RS17505	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EZ304_RS17510	COG0477	Major facilitator Superfamily
EZ304_RS17520	COG0617	tRNA 3'-terminal CCA addition
EZ304_RS17530	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EZ304_RS17535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EZ304_RS17545	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EZ304_RS17555	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EZ304_RS17565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EZ304_RS17570	COG0671	phosphoesterase, PA-phosphatase related
EZ304_RS17580	COG0800	Aldolase
EZ304_RS17585	COG0129	dihydroxy-acid dehydratase activity
EZ304_RS17595	COG0837	glucose binding
EZ304_RS17640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EZ304_RS17645	COG1053	succinate dehydrogenase
EZ304_RS17665	COG4591	ABC-type transport system involved in lipoprotein release permease component
EZ304_RS17680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EZ304_RS17690	COG0552	protein localization to endoplasmic reticulum
EZ304_RS17710	COG0742	ribosomal rna small subunit methyltransferase
EZ304_RS17715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EZ304_RS17725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EZ304_RS17730	COG0405	Gamma-glutamyltransferase
EZ304_RS17735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZ304_RS17755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EZ304_RS17775	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EZ304_RS17780	COG0415	Belongs to the DNA photolyase family
EZ304_RS17785	COG2885	chlorophyll binding
EZ304_RS17790	COG0583	DNA-binding transcription factor activity
EZ304_RS17815	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS17945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EZ304_RS17955	COG2914	Belongs to the UPF0125 (RnfH) family
EZ304_RS17960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZ304_RS17965	COG0735	belongs to the Fur family
EZ304_RS17975	COG0583	DNA-binding transcription factor activity
EZ304_RS17980	COG0497	DNA recombination
EZ304_RS17985	COG1420	regulation of RNA biosynthetic process
EZ304_RS17990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EZ304_RS17995	COG0443	Heat shock 70 kDa protein
EZ304_RS18000	COG0484	heat shock protein binding
EZ304_RS18005	COG2207	Transcriptional regulator
EZ304_RS18010	COG2223	nitrite transmembrane transporter activity
EZ304_RS18025	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EZ304_RS18030	COG0287	Prephenate dehydrogenase
EZ304_RS18030	COG1605	Chorismate mutase
EZ304_RS18040	COG1132	(ABC) transporter
EZ304_RS18070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EZ304_RS18075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EZ304_RS18080	COG0343	queuine tRNA-ribosyltransferase activity
EZ304_RS18085	COG1862	Preprotein translocase
EZ304_RS18095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZ304_RS18100	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZ304_RS18110	COG2081	HI0933 family
EZ304_RS18115	COG4681	YaeQ
EZ304_RS18135	COG0625	glutathione transferase activity
EZ304_RS18140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EZ304_RS18155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EZ304_RS18160	COG0513	Belongs to the DEAD box helicase family
EZ304_RS18170	COG0583	DNA-binding transcription factor activity
EZ304_RS18175	COG0488	(ABC) transporter
EZ304_RS18200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZ304_RS18215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZ304_RS18220	COG2957	Belongs to the agmatine deiminase family
EZ304_RS18230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EZ304_RS18235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EZ304_RS18245	COG0776	regulation of translation
EZ304_RS18255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EZ304_RS18260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EZ304_RS18270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EZ304_RS18275	COG0183	Belongs to the thiolase family
EZ304_RS18280	COG1024	Enoyl-CoA hydratase
EZ304_RS18280	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZ304_RS18290	COG0105	UTP biosynthetic process
EZ304_RS18295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EZ304_RS18300	COG0859	PFAM glycosyl transferase family 9
EZ304_RS18300	COG0457	Tetratricopeptide repeat
EZ304_RS18305	COG1426	Protein conserved in bacteria
EZ304_RS18305	COG1426	Protein conserved in bacteria
EZ304_RS18315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZ304_RS18320	COG1160	GTP binding
EZ304_RS18325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EZ304_RS18330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZ304_RS18330	COG0475	glutathione-regulated potassium exporter activity
EZ304_RS18345	COG0519	Catalyzes the synthesis of GMP from XMP
EZ304_RS18345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZ304_RS18370	COG0583	DNA-binding transcription factor activity
EZ304_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS18425	COG0640	Transcriptional regulator
EZ304_RS18440	COG0300	oxidoreductase activity
EZ304_RS18445	COG2207	Transcriptional regulator
EZ304_RS18470	COG0431	NADPH-dependent FMN reductase
EZ304_RS18480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZ304_RS18485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EZ304_RS18490	COG1473	amidohydrolase
EZ304_RS18500	COG1126	abc transporter atp-binding protein
EZ304_RS18505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ304_RS18530	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EZ304_RS18535	COG0583	DNA-binding transcription factor activity
EZ304_RS18540	COG0477	Major facilitator Superfamily
EZ304_RS18545	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS18575	COG1309	transcriptional regulator
EZ304_RS18590	COG0697	spore germination
EZ304_RS18595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EZ304_RS18600	COG0167	dihydroorotate dehydrogenase activity
EZ304_RS18615	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS18620	COG1012	belongs to the aldehyde dehydrogenase family
EZ304_RS18675	COG0745	RESPONSE REGULATOR receiver
EZ304_RS18680	COG0784	Response regulator, receiver
EZ304_RS18680	COG4191	Histidine kinase
EZ304_RS18685	COG2205	protein histidine kinase activity
EZ304_RS18685	COG3850	Histidine kinase
EZ304_RS18685	COG4999	Histidine kinase
EZ304_RS18685	COG3437	response regulator, receiver
EZ304_RS18690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EZ304_RS18700	COG0745	RESPONSE REGULATOR receiver
EZ304_RS18710	COG0640	Transcriptional regulator
EZ304_RS18745	COG0527	aspartate kinase activity
EZ304_RS18745	COG0460	homoserine dehydrogenase
EZ304_RS18755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EZ304_RS18760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZ304_RS18765	COG0124	histidyl-tRNA synthetase
EZ304_RS18780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EZ304_RS18785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EZ304_RS18790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZ304_RS18795	COG0131	Imidazoleglycerol-phosphate dehydratase
EZ304_RS18795	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EZ304_RS18800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EZ304_RS18805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EZ304_RS18810	COG0107	imidazoleglycerol-phosphate synthase activity
EZ304_RS18815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EZ304_RS18815	COG0140	phosphoribosyl-ATP diphosphatase activity
EZ304_RS18835	COG1446	asparaginase
EZ304_RS18840	COG3142	Participates in the control of copper homeostasis
EZ304_RS18855	COG0789	Transcriptional regulator
EZ304_RS18875	COG3537	Alpha-1,2-mannosidase
EZ304_RS18880	COG1609	Transcriptional regulator
EZ304_RS18890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZ304_RS18905	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
EZ304_RS18910	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EZ304_RS18915	COG0235	Class ii aldolase
EZ304_RS18920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EZ304_RS18925	COG0739	heme binding
EZ304_RS18940	COG2223	nitrite transmembrane transporter activity
EZ304_RS18945	COG0708	Exodeoxyribonuclease III
EZ304_RS18950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EZ304_RS18965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EZ304_RS18970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EZ304_RS18980	COG2205	protein histidine kinase activity
EZ304_RS18995	COG0756	dUTP diphosphatase activity
EZ304_RS19000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EZ304_RS19005	COG2197	response regulator
EZ304_RS19015	COG2003	Belongs to the UPF0758 family
EZ304_RS19020	COG0018	arginyl-trna synthetase
EZ304_RS19030	COG4221	oxidoreductase activity
EZ304_RS19035	COG4807	Protein conserved in bacteria
EZ304_RS19040	COG0583	DNA-binding transcription factor activity
EZ304_RS19045	COG2814	Major facilitator Superfamily
EZ304_RS19075	COG5507	3-demethylubiquinone-9 3-methyltransferase
EZ304_RS19090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZ304_RS19110	COG0628	permease
EZ304_RS19120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZ304_RS19135	COG2197	response regulator
EZ304_RS19140	COG4585	Histidine kinase
EZ304_RS19155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZ304_RS19160	COG1136	(ABC) transporter
EZ304_RS19170	COG0577	efflux transmembrane transporter activity
EZ304_RS19170	COG1136	(ABC) transporter
EZ304_RS19185	COG0697	spore germination
EZ304_RS19190	COG0477	Major facilitator Superfamily
EZ304_RS19210	COG0180	Tryptophanyl-tRNA synthetase
EZ304_RS19220	COG3237	CsbD-like
EZ304_RS19285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EZ304_RS19290	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EZ304_RS19290	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EZ304_RS19325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZ304_RS19345	COG0659	secondary active sulfate transmembrane transporter activity
EZ304_RS19355	COG1764	response to oxidative stress
EZ304_RS19365	COG1024	Enoyl-CoA hydratase
EZ304_RS19370	COG1024	Enoyl-CoA hydratase
EZ304_RS19375	COG1960	acyl-CoA dehydrogenase activity
EZ304_RS19385	COG3800	Transcriptional regulator
EZ304_RS19385	COG1396	sequence-specific DNA binding
EZ304_RS19400	COG1752	Esterase of the alpha-beta hydrolase superfamily
EZ304_RS19410	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EZ304_RS19415	COG1335	isochorismatase
EZ304_RS19430	COG1902	pentaerythritol trinitrate reductase activity
EZ304_RS19440	COG1607	acyl-coa hydrolase
EZ304_RS19445	COG1280	lysine exporter protein (LysE YggA)
EZ304_RS19455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZ304_RS19470	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EZ304_RS19480	COG0697	spore germination
EZ304_RS19500	COG1960	acyl-CoA dehydrogenase activity
EZ304_RS19505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EZ304_RS19530	COG3706	GGDEF domain
EZ304_RS19535	COG2224	Isocitrate lyase
EZ304_RS19540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EZ304_RS19545	COG0583	DNA-binding transcription factor activity
EZ304_RS19555	COG0583	DNA-binding transcription factor activity
EZ304_RS19560	COG2814	Major facilitator Superfamily
EZ304_RS19565	COG0681	Belongs to the peptidase S26 family
EZ304_RS19580	COG0339	signal peptide processing
EZ304_RS19610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EZ304_RS19615	COG1215	transferase activity, transferring glycosyl groups
EZ304_RS19630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EZ304_RS19645	COG1181	Belongs to the D-alanine--D-alanine ligase family
EZ304_RS19655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZ304_RS19660	COG0318	PFAM AMP-dependent synthetase and ligase
EZ304_RS19670	COG0596	Alpha beta hydrolase
EZ304_RS19675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZ304_RS19685	COG0612	Peptidase, M16
EZ304_RS19695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EZ304_RS19700	COG1960	acyl-CoA dehydrogenase activity
EZ304_RS19710	COG3474	cytochrome
EZ304_RS19715	COG2205	protein histidine kinase activity
EZ304_RS19715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ304_RS19720	COG2197	response regulator
EZ304_RS19760	COG2837	iron assimilation
EZ304_RS19815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EZ304_RS19820	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EZ304_RS19855	COG0183	Belongs to the thiolase family
EZ304_RS19865	COG2032	superoxide dismutase activity
EZ304_RS19870	COG2032	superoxide dismutase activity
EZ304_RS19875	COG2204	response regulator
EZ304_RS19880	COG3852	Histidine kinase
EZ304_RS19905	COG0659	secondary active sulfate transmembrane transporter activity
EZ304_RS19910	COG0640	Transcriptional regulator
EZ304_RS19930	COG3453	Protein conserved in bacteria
EZ304_RS19930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZ304_RS19945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EZ304_RS19995	COG0464	growth
EZ304_RS20005	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EZ304_RS20035	COG3210	domain, Protein
EZ304_RS20040	COG2831	hemolysin activation secretion protein
EZ304_RS20045	COG0004	ammonium transporteR
EZ304_RS20050	COG0347	Belongs to the P(II) protein family
EZ304_RS20055	COG0174	glutamine synthetase
EZ304_RS20060	COG1968	undecaprenyl-diphosphatase activity
EZ304_RS20075	COG1881	PFAM PEBP family protein
EZ304_RS20100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EZ304_RS20120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZ304_RS20140	COG3550	peptidyl-serine autophosphorylation
EZ304_RS20150	COG0312	modulator of DNA gyrase
EZ304_RS20170	COG0714	Associated with various cellular activities
EZ304_RS20205	COG1205	dead DEAH box helicase
EZ304_RS20205	COG1111	helicase
EZ304_RS20235	COG2814	Major facilitator Superfamily
EZ304_RS20265	COG1028	Short-chain dehydrogenase reductase Sdr
EZ304_RS20285	COG0067	glutamate synthase
EZ304_RS20285	COG0069	glutamate synthase activity
EZ304_RS20285	COG0070	glutamate synthase
EZ304_RS20290	COG0493	'glutamate synthase
EZ304_RS20295	COG2205	protein histidine kinase activity
EZ304_RS20295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZ304_RS20300	COG1803	Methylglyoxal synthase
EZ304_RS20310	COG2974	May be involved in recombination
EZ304_RS20315	COG0037	tRNA processing
EZ304_RS20325	COG2937	Belongs to the GPAT DAPAT family
EZ304_RS20335	COG0284	orotidine-5'-phosphate decarboxylase activity
EZ304_RS20340	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EZ304_RS20345	COG3132	Protein of unknown function, DUF480
EZ304_RS20355	COG0210	DNA helicase
EZ304_RS20370	COG1435	thymidine kinase activity
EZ304_RS20375	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EZ304_RS20380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EZ304_RS20395	COG1119	ATPase activity
EZ304_RS20415	COG4771	TonB-dependent receptor
EZ304_RS20425	COG1752	Esterase of the alpha-beta hydrolase superfamily
EZ304_RS20435	COG1522	sequence-specific DNA binding
EZ304_RS20440	COG3186	Phenylalanine-4-hydroxylase
EZ304_RS20455	COG0800	Aldolase
EZ304_RS20490	COG4772	TonB-dependent receptor
EZ304_RS20500	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EZ304_RS20555	COG0501	Belongs to the peptidase M48B family
EZ304_RS20565	COG0187	DNA topoisomerase II activity
EZ304_RS20570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZ304_RS20580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZ304_RS20585	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EZ304_RS20590	COG0594	ribonuclease P activity
EZ304_RS20595	COG0706	membrane insertase activity
EZ304_RS20610	COG0584	glycerophosphoryl diester phosphodiesterase
EZ304_RS20620	COG0861	Integral membrane protein TerC family
EZ304_RS20625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EZ304_RS20645	COG0531	amino acid
EZ304_RS20665	COG0583	DNA-binding transcription factor activity
EZ304_RS20680	COG1322	Protein conserved in bacteria
EZ304_RS20690	COG0386	Belongs to the glutathione peroxidase family
EZ304_RS20695	COG2853	Lipoprotein
EZ304_RS20710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EZ304_RS20715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EZ304_RS20720	COG1127	ABC transporter
EZ304_RS20725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EZ304_RS20730	COG1074	ATP-dependent DNA helicase activity
EZ304_RS20750	COG1289	transmembrane transporter activity
EZ304_RS20760	COG1566	PFAM secretion protein HlyD family protein
EZ304_RS20775	COG0302	gtp cyclohydrolase
EZ304_RS20805	COG3706	GGDEF domain
EZ304_RS20810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZ304_RS20815	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EZ304_RS20820	COG2951	lytic endotransglycosylase activity
EZ304_RS20835	COG3135	benzoate transporter
EZ304_RS20885	COG0531	amino acid
EZ304_RS20890	COG0531	amino acid
EZ304_RS20900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZ304_RS20905	COG0277	FAD linked oxidase domain protein