locus-tag	class	description
LAD79_RS00045	COG3135	benzoate transporter
LAD79_RS00060	COG2951	lytic endotransglycosylase activity
LAD79_RS00065	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LAD79_RS00070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LAD79_RS00075	COG3706	GGDEF domain
LAD79_RS00105	COG0302	gtp cyclohydrolase
LAD79_RS00120	COG1566	PFAM secretion protein HlyD family protein
LAD79_RS00130	COG1289	transmembrane transporter activity
LAD79_RS00145	COG1074	ATP-dependent DNA helicase activity
LAD79_RS00150	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LAD79_RS00155	COG1127	ABC transporter
LAD79_RS00160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LAD79_RS00165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LAD79_RS00180	COG2853	Lipoprotein
LAD79_RS00185	COG0386	Belongs to the glutathione peroxidase family
LAD79_RS00195	COG1322	Protein conserved in bacteria
LAD79_RS00205	COG0604	alcohol dehydrogenase
LAD79_RS00210	COG0583	DNA-binding transcription factor activity
LAD79_RS00230	COG0531	amino acid
LAD79_RS00240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LAD79_RS00245	COG0861	Integral membrane protein TerC family
LAD79_RS00255	COG0584	glycerophosphoryl diester phosphodiesterase
LAD79_RS00270	COG0706	membrane insertase activity
LAD79_RS00275	COG0594	ribonuclease P activity
LAD79_RS00280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LAD79_RS00285	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LAD79_RS00295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LAD79_RS00300	COG0187	DNA topoisomerase II activity
LAD79_RS00305	COG1266	CAAX protease self-immunity
LAD79_RS00310	COG0501	Belongs to the peptidase M48B family
LAD79_RS00385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LAD79_RS00405	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS00450	COG3422	double-strand break repair
LAD79_RS00460	COG0659	secondary active sulfate transmembrane transporter activity
LAD79_RS00475	COG0798	PFAM Bile acid sodium symporter
LAD79_RS00490	COG0431	NADPH-dependent FMN reductase
LAD79_RS00515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LAD79_RS00530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LAD79_RS00530	COG3453	Protein conserved in bacteria
LAD79_RS00550	COG0640	Transcriptional regulator
LAD79_RS00595	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LAD79_RS00605	COG4772	TonB-dependent receptor
LAD79_RS00640	COG0800	Aldolase
LAD79_RS00655	COG3186	Phenylalanine-4-hydroxylase
LAD79_RS00660	COG1522	sequence-specific DNA binding
LAD79_RS00665	COG1752	Esterase of the alpha-beta hydrolase superfamily
LAD79_RS00675	COG4771	TonB-dependent receptor
LAD79_RS00695	COG1119	ATPase activity
LAD79_RS00710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LAD79_RS00715	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LAD79_RS00735	COG0210	DNA helicase
LAD79_RS00745	COG3132	Protein of unknown function, DUF480
LAD79_RS00750	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LAD79_RS00755	COG0284	orotidine-5'-phosphate decarboxylase activity
LAD79_RS00765	COG2937	Belongs to the GPAT DAPAT family
LAD79_RS00775	COG0037	tRNA processing
LAD79_RS00780	COG2974	May be involved in recombination
LAD79_RS00790	COG1803	Methylglyoxal synthase
LAD79_RS00795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAD79_RS00795	COG2205	protein histidine kinase activity
LAD79_RS00800	COG0493	'glutamate synthase
LAD79_RS00805	COG0070	glutamate synthase
LAD79_RS00805	COG0069	glutamate synthase activity
LAD79_RS00805	COG0067	glutamate synthase
LAD79_RS00825	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS00840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LAD79_RS00865	COG1205	dead DEAH box helicase
LAD79_RS00865	COG1111	helicase
LAD79_RS00900	COG0714	Associated with various cellular activities
LAD79_RS00920	COG0312	modulator of DNA gyrase
LAD79_RS00935	COG3550	peptidyl-serine autophosphorylation
LAD79_RS00955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LAD79_RS00975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LAD79_RS01000	COG1881	PFAM PEBP family protein
LAD79_RS01015	COG1968	undecaprenyl-diphosphatase activity
LAD79_RS01020	COG0174	glutamine synthetase
LAD79_RS01025	COG0347	Belongs to the P(II) protein family
LAD79_RS01030	COG0004	ammonium transporteR
LAD79_RS01035	COG3023	N-Acetylmuramoyl-L-alanine amidase
LAD79_RS01045	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LAD79_RS01060	COG3852	Histidine kinase
LAD79_RS01065	COG2204	response regulator
LAD79_RS01070	COG2032	superoxide dismutase activity
LAD79_RS01075	COG2032	superoxide dismutase activity
LAD79_RS01085	COG0183	Belongs to the thiolase family
LAD79_RS01120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LAD79_RS01125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LAD79_RS01145	COG0798	PFAM Bile acid sodium symporter
LAD79_RS01160	COG0431	NADPH-dependent FMN reductase
LAD79_RS01195	COG2837	iron assimilation
LAD79_RS01240	COG2197	response regulator
LAD79_RS01245	COG2205	protein histidine kinase activity
LAD79_RS01245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAD79_RS01250	COG3474	cytochrome
LAD79_RS01260	COG1960	acyl-CoA dehydrogenase activity
LAD79_RS01265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LAD79_RS01275	COG0612	Peptidase, M16
LAD79_RS01285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LAD79_RS01290	COG0596	Alpha beta hydrolase
LAD79_RS01300	COG0318	PFAM AMP-dependent synthetase and ligase
LAD79_RS01305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LAD79_RS01315	COG1181	Belongs to the D-alanine--D-alanine ligase family
LAD79_RS01325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LAD79_RS01340	COG1215	transferase activity, transferring glycosyl groups
LAD79_RS01345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LAD79_RS01375	COG0339	signal peptide processing
LAD79_RS01390	COG0681	Belongs to the peptidase S26 family
LAD79_RS01395	COG2814	Major facilitator Superfamily
LAD79_RS01400	COG3415	Transposase
LAD79_RS01400	COG2801	Transposase and inactivated derivatives
LAD79_RS01410	COG0583	DNA-binding transcription factor activity
LAD79_RS01415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LAD79_RS01420	COG2224	Isocitrate lyase
LAD79_RS01425	COG3706	GGDEF domain
LAD79_RS01450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LAD79_RS01455	COG1960	acyl-CoA dehydrogenase activity
LAD79_RS01480	COG0697	spore germination
LAD79_RS01490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LAD79_RS01500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAD79_RS01510	COG1280	lysine exporter protein (LysE YggA)
LAD79_RS01515	COG1607	acyl-coa hydrolase
LAD79_RS01525	COG1902	pentaerythritol trinitrate reductase activity
LAD79_RS01540	COG1335	isochorismatase
LAD79_RS01545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LAD79_RS01555	COG1051	belongs to the nudix hydrolase family
LAD79_RS01555	COG1056	cytidyltransferase-related domain
LAD79_RS01560	COG1752	Esterase of the alpha-beta hydrolase superfamily
LAD79_RS01565	COG3800	Transcriptional regulator
LAD79_RS01565	COG1396	sequence-specific DNA binding
LAD79_RS01575	COG1960	acyl-CoA dehydrogenase activity
LAD79_RS01580	COG1024	Enoyl-CoA hydratase
LAD79_RS01585	COG1024	Enoyl-CoA hydratase
LAD79_RS01595	COG1764	response to oxidative stress
LAD79_RS01620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LAD79_RS01640	COG3228	Belongs to the MtfA family
LAD79_RS01650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LAD79_RS01650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LAD79_RS01655	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LAD79_RS01685	COG3657	addiction module killer protein
LAD79_RS01715	COG0010	Belongs to the arginase family
LAD79_RS01725	COG3237	CsbD-like
LAD79_RS01735	COG0180	Tryptophanyl-tRNA synthetase
LAD79_RS01760	COG0477	Major facilitator Superfamily
LAD79_RS01770	COG4152	abc transporter atp-binding protein
LAD79_RS01785	COG0697	spore germination
LAD79_RS01795	COG4206	TonB-dependent receptor
LAD79_RS01800	COG0577	efflux transmembrane transporter activity
LAD79_RS01800	COG1136	(ABC) transporter
LAD79_RS01810	COG1136	(ABC) transporter
LAD79_RS01830	COG4585	Histidine kinase
LAD79_RS01835	COG2197	response regulator
LAD79_RS01850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LAD79_RS01865	COG0628	permease
LAD79_RS01885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LAD79_RS01900	COG5507	3-demethylubiquinone-9 3-methyltransferase
LAD79_RS01915	COG2197	response regulator
LAD79_RS01935	COG0583	DNA-binding transcription factor activity
LAD79_RS01940	COG4807	Protein conserved in bacteria
LAD79_RS01950	COG4221	oxidoreductase activity
LAD79_RS01960	COG0018	arginyl-trna synthetase
LAD79_RS01965	COG2003	Belongs to the UPF0758 family
LAD79_RS01975	COG2197	response regulator
LAD79_RS01980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LAD79_RS02000	COG2205	protein histidine kinase activity
LAD79_RS02010	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LAD79_RS02015	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LAD79_RS02030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LAD79_RS02035	COG0708	Exodeoxyribonuclease III
LAD79_RS02040	COG2223	nitrite transmembrane transporter activity
LAD79_RS02055	COG0739	heme binding
LAD79_RS02060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LAD79_RS02120	COG2234	aminopeptidase activity
LAD79_RS02130	COG4942	peptidase
LAD79_RS02135	COG0793	Belongs to the peptidase S41A family
LAD79_RS02170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LAD79_RS02215	COG0109	protoheme IX farnesyltransferase activity
LAD79_RS02235	COG0358	DNA primase activity
LAD79_RS02240	COG1295	ribonuclease BN
LAD79_RS02255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LAD79_RS02265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LAD79_RS02270	COG0668	transmembrane transport
LAD79_RS02285	COG2133	pyrroloquinoline quinone binding
LAD79_RS02290	COG4682	membrane
LAD79_RS02300	COG0531	amino acid
LAD79_RS02310	COG1737	Transcriptional regulator
LAD79_RS02315	COG4948	Mandelate Racemase Muconate Lactonizing
LAD79_RS02370	COG5383	Protein conserved in bacteria
LAD79_RS02380	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LAD79_RS02385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LAD79_RS02415	COG0778	Nitroreductase
LAD79_RS02420	COG2353	YceI-like domain
LAD79_RS02435	COG2375	cellular response to nickel ion
LAD79_RS02555	COG2267	carboxylic ester hydrolase activity
LAD79_RS02620	COG0488	(ABC) transporter
LAD79_RS02625	COG0583	DNA-binding transcription factor activity
LAD79_RS02635	COG2814	Major facilitator Superfamily
LAD79_RS02640	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LAD79_RS02645	COG1113	amino acid transport
LAD79_RS02650	COG0741	lytic transglycosylase activity
LAD79_RS02665	COG3795	YCII-related domain
LAD79_RS02680	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LAD79_RS02690	COG5507	3-demethylubiquinone-9 3-methyltransferase
LAD79_RS02695	COG4941	Belongs to the sigma-70 factor family
LAD79_RS02725	COG3275	phosphorelay sensor kinase activity
LAD79_RS02730	COG3279	Response regulator of the LytR AlgR family
LAD79_RS02750	COG1309	transcriptional regulator
LAD79_RS02765	COG3590	peptidase
LAD79_RS02770	COG5001	Diguanylate cyclase
LAD79_RS02775	COG0583	DNA-binding transcription factor activity
LAD79_RS02785	COG3384	dioxygenase
LAD79_RS02790	COG0025	NhaP-type Na H and K H
LAD79_RS02815	COG1360	Flagellar Motor Protein
LAD79_RS02845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LAD79_RS02860	COG5002	protein histidine kinase activity
LAD79_RS02875	COG2813	Specifically methylates the guanine in position
LAD79_RS02880	COG1187	pseudouridine synthase activity
LAD79_RS02885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LAD79_RS02895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LAD79_RS02900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LAD79_RS02915	COG0583	DNA-binding transcription factor activity
LAD79_RS02920	COG2226	methyltransferase
LAD79_RS02945	COG1956	GAF domain-containing protein
LAD79_RS02950	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LAD79_RS02955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LAD79_RS02960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LAD79_RS02965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LAD79_RS02965	COG0785	Cytochrome C biogenesis protein
LAD79_RS02970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LAD79_RS02975	COG0745	RESPONSE REGULATOR receiver
LAD79_RS02980	COG2205	protein histidine kinase activity
LAD79_RS02985	COG2205	protein histidine kinase activity
LAD79_RS02990	COG0745	RESPONSE REGULATOR receiver
LAD79_RS02995	COG0367	asparagine synthase
LAD79_RS03005	COG0720	synthase
LAD79_RS03020	COG0513	Belongs to the DEAD box helicase family
LAD79_RS03030	COG0625	glutathione transferase activity
LAD79_RS03035	COG1573	uracil-dna glycosylase
LAD79_RS03070	COG0626	cystathionine gamma-synthase activity
LAD79_RS03135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LAD79_RS03135	COG0546	phosphoglycolate phosphatase activity
LAD79_RS03170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LAD79_RS03175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LAD79_RS03235	COG1127	ABC transporter
LAD79_RS03240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LAD79_RS03255	COG0442	prolyl-tRNA aminoacylation
LAD79_RS03265	COG1183	phosphatidylcholine synthase activity
LAD79_RS03275	COG0456	acetyltransferase
LAD79_RS03285	COG0525	valine-tRNA ligase activity
LAD79_RS03295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LAD79_RS03305	COG0795	lipopolysaccharide-transporting ATPase activity
LAD79_RS03320	COG4974	Belongs to the 'phage' integrase family
LAD79_RS03325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LAD79_RS03335	COG0047	phosphoribosylformylglycinamidine synthase activity
LAD79_RS03335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LAD79_RS03340	COG5295	Hep Hag repeat protein
LAD79_RS03345	COG1404	Belongs to the peptidase S8 family
LAD79_RS03350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LAD79_RS03355	COG1459	type II secretion system
LAD79_RS03360	COG2165	general secretion pathway protein
LAD79_RS03365	COG4970	Tfp pilus assembly protein FimT
LAD79_RS03370	COG2165	general secretion pathway protein
LAD79_RS03375	COG4795	General secretion pathway protein
LAD79_RS03380	COG3156	type II secretion system protein K
LAD79_RS03385	COG3166	PFAM Fimbrial assembly family protein
LAD79_RS03400	COG1450	Type ii and iii secretion system protein
LAD79_RS03415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LAD79_RS03425	COG3539	Fimbrial protein
LAD79_RS03445	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LAD79_RS03455	COG1215	transferase activity, transferring glycosyl groups
LAD79_RS03470	COG2252	PERMEase
LAD79_RS03475	COG0488	(ABC) transporter
LAD79_RS03485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LAD79_RS03505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LAD79_RS03510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LAD79_RS03510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LAD79_RS03545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LAD79_RS03550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LAD79_RS03565	COG3121	Chaperone
LAD79_RS03580	COG3188	usher protein
LAD79_RS03590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LAD79_RS03590	COG2755	lipolytic protein G-D-S-L family
LAD79_RS03595	COG0277	FAD linked oxidase domain protein
LAD79_RS03600	COG1988	membrane-bound metal-dependent
LAD79_RS03645	COG2001	Belongs to the MraZ family
LAD79_RS03650	COG0275	rRNA processing
LAD79_RS03655	COG3116	cell division
LAD79_RS03670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LAD79_RS03690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LAD79_RS03695	COG1181	Belongs to the D-alanine--D-alanine ligase family
LAD79_RS03700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LAD79_RS03710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LAD79_RS03715	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LAD79_RS03725	COG0739	heme binding
LAD79_RS03730	COG0653	protein targeting
LAD79_RS03735	COG0494	nUDIX hydrolase
LAD79_RS03745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LAD79_RS03755	COG3275	phosphorelay sensor kinase activity
LAD79_RS03760	COG3279	Response regulator of the LytR AlgR family
LAD79_RS03780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LAD79_RS03785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LAD79_RS03800	COG1607	acyl-coa hydrolase
LAD79_RS03805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LAD79_RS03835	COG4106	trans-aconitate 2-methyltransferase activity
LAD79_RS03840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LAD79_RS03860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAD79_RS03865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LAD79_RS03870	COG0667	Aldo Keto reductase
LAD79_RS03880	COG4771	TonB-dependent receptor
LAD79_RS03895	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LAD79_RS03900	COG4181	ATPase activity
LAD79_RS03915	COG0642	Histidine kinase
LAD79_RS03925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LAD79_RS03930	COG0861	Integral membrane protein TerC family
LAD79_RS03935	COG2814	Major facilitator Superfamily
LAD79_RS03950	COG1704	LemA family
LAD79_RS03965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LAD79_RS03970	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LAD79_RS03980	COG3738	Protein conserved in bacteria
LAD79_RS03985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LAD79_RS03990	COG2967	ApaG domain
LAD79_RS03995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LAD79_RS04000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LAD79_RS04005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LAD79_RS04010	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LAD79_RS04020	COG2096	Adenosyltransferase
LAD79_RS04030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LAD79_RS04035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LAD79_RS04040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LAD79_RS04045	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LAD79_RS04065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LAD79_RS04075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LAD79_RS04085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LAD79_RS04090	COG0583	DNA-binding transcription factor activity
LAD79_RS04095	COG3634	alkyl hydroperoxide reductase activity
LAD79_RS04135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LAD79_RS04135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LAD79_RS04150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LAD79_RS04175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LAD79_RS04190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LAD79_RS04195	COG1404	Belongs to the peptidase S8 family
LAD79_RS04215	COG1295	ribonuclease BN
LAD79_RS04220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LAD79_RS04245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LAD79_RS04250	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LAD79_RS04265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LAD79_RS04275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LAD79_RS04280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LAD79_RS04285	COG0193	aminoacyl-tRNA hydrolase activity
LAD79_RS04290	COG0012	GTP binding
LAD79_RS04300	COG2197	response regulator
LAD79_RS04305	COG2205	protein histidine kinase activity
LAD79_RS04305	COG0784	Response regulator, receiver
LAD79_RS04310	COG2199	diguanylate cyclase activity
LAD79_RS04310	COG2200	EAL domain
LAD79_RS04310	COG2203	Gaf domain
LAD79_RS04315	COG2205	protein histidine kinase activity
LAD79_RS04315	COG0784	Response regulator, receiver
LAD79_RS04320	COG4206	TonB-dependent receptor
LAD79_RS04350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LAD79_RS04365	COG0250	Participates in transcription elongation, termination and antitermination
LAD79_RS04370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LAD79_RS04375	COG0081	regulation of translation
LAD79_RS04380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LAD79_RS04385	COG0222	ribosome binding
LAD79_RS04390	COG0085	RNA polymerase activity
LAD79_RS04395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LAD79_RS04400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LAD79_RS04405	COG0049	tRNA binding
LAD79_RS04410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LAD79_RS04415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LAD79_RS04420	COG0051	transcription antitermination factor activity, RNA binding
LAD79_RS04425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LAD79_RS04430	COG0088	Forms part of the polypeptide exit tunnel
LAD79_RS04435	COG0089	rRNA binding
LAD79_RS04440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LAD79_RS04445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LAD79_RS04450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LAD79_RS04455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LAD79_RS04460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LAD79_RS04465	COG0255	Belongs to the universal ribosomal protein uL29 family
LAD79_RS04470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LAD79_RS04475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LAD79_RS04480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LAD79_RS04485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LAD79_RS04490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LAD79_RS04495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LAD79_RS04500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LAD79_RS04505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LAD79_RS04510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LAD79_RS04515	COG1841	ribosomal large subunit assembly
LAD79_RS04520	COG0200	Binds to the 23S rRNA
LAD79_RS04525	COG0201	protein transport
LAD79_RS04530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LAD79_RS04535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LAD79_RS04540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LAD79_RS04545	COG0202	RNA polymerase activity
LAD79_RS04550	COG0203	ribosomal protein L17
LAD79_RS04565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LAD79_RS04575	COG0154	amidase activity
LAD79_RS04590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LAD79_RS04595	COG0039	L-malate dehydrogenase activity
LAD79_RS04600	COG0564	pseudouridine synthase activity
LAD79_RS04610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LAD79_RS04625	COG0625	glutathione transferase activity
LAD79_RS04635	COG0446	pyridine nucleotide-disulphide oxidoreductase
LAD79_RS04635	COG1902	pentaerythritol trinitrate reductase activity
LAD79_RS04640	COG2364	Membrane
LAD79_RS04645	COG0604	alcohol dehydrogenase
LAD79_RS04660	COG1187	pseudouridine synthase activity
LAD79_RS04680	COG1063	alcohol dehydrogenase
LAD79_RS04690	COG0406	alpha-ribazole phosphatase activity
LAD79_RS04695	COG0285	dihydrofolate synthase activity
LAD79_RS04715	COG2833	Protein of unknown function (DUF455)
LAD79_RS04725	COG3291	Pkd domain containing protein
LAD79_RS04730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LAD79_RS04740	COG0438	transferase activity, transferring glycosyl groups
LAD79_RS04755	COG0248	Ppx GppA phosphatase
LAD79_RS04760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LAD79_RS04775	COG4783	chaperone-mediated protein folding
LAD79_RS04790	COG0473	3-isopropylmalate dehydrogenase activity
LAD79_RS04850	COG0544	peptidyl-prolyl cis-trans isomerase activity
LAD79_RS04855	COG0740	serine-type endopeptidase activity
LAD79_RS04860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LAD79_RS04900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LAD79_RS04905	COG1388	LysM domain
LAD79_RS04905	COG3942	CHAP domain
LAD79_RS04910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LAD79_RS04920	COG0328	RNA-DNA hybrid ribonuclease activity
LAD79_RS04925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LAD79_RS04930	COG0631	protein serine/threonine phosphatase activity
LAD79_RS04950	COG0859	PFAM glycosyl transferase family 9
LAD79_RS04955	COG3642	lipopolysaccharide core region biosynthetic process
LAD79_RS04960	COG1234	tRNA 3'-trailer cleavage
LAD79_RS04975	COG2076	Multidrug Resistance protein
LAD79_RS05005	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LAD79_RS05015	COG0537	adenosine 5'-monophosphoramidase activity
LAD79_RS05035	COG0714	Associated with various cellular activities
LAD79_RS05045	COG3415	Transposase
LAD79_RS05045	COG2801	Transposase and inactivated derivatives
LAD79_RS05055	COG1399	metal-binding, possibly nucleic acid-binding protein
LAD79_RS05060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LAD79_RS05065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LAD79_RS05075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LAD79_RS05080	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS05090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LAD79_RS05095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LAD79_RS05100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LAD79_RS05105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LAD79_RS05145	COG2226	methyltransferase
LAD79_RS05155	COG0583	DNA-binding transcription factor activity
LAD79_RS05160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LAD79_RS05165	COG0697	spore germination
LAD79_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS05175	COG0583	DNA-binding transcription factor activity
LAD79_RS05185	COG0477	Major facilitator Superfamily
LAD79_RS05220	COG0583	DNA-binding transcription factor activity
LAD79_RS05230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LAD79_RS05245	COG0667	Aldo Keto reductase
LAD79_RS05265	COG0519	Catalyzes the synthesis of GMP from XMP
LAD79_RS05270	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LAD79_RS05275	COG1678	Uncharacterized ACR, COG1678
LAD79_RS05280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LAD79_RS05285	COG0540	Belongs to the ATCase OTCase family
LAD79_RS05305	COG2239	Acts as a magnesium transporter
LAD79_RS05310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LAD79_RS05325	COG1660	Displays ATPase and GTPase activities
LAD79_RS05330	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LAD79_RS05335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAD79_RS05340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LAD79_RS05350	COG1137	ATPase activity
LAD79_RS05365	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LAD79_RS05380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LAD79_RS05400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LAD79_RS05420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LAD79_RS05430	COG0628	permease
LAD79_RS05440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LAD79_RS05450	COG2261	transglycosylase associated protein
LAD79_RS05460	COG1555	photosystem II stabilization
LAD79_RS05480	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LAD79_RS05485	COG1477	protein flavinylation
LAD79_RS05505	COG4771	TonB-dependent receptor
LAD79_RS05515	COG3128	pkhd-type hydroxylase
LAD79_RS05525	COG4774	siderophore transport
LAD79_RS05535	COG2146	nitrite reductase [NAD(P)H] activity
LAD79_RS05550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LAD79_RS05555	COG0719	Fe-S assembly protein
LAD79_RS05560	COG0396	ATPase activity
LAD79_RS05570	COG0719	Fe-S assembly protein
LAD79_RS05575	COG1959	2 iron, 2 sulfur cluster binding
LAD79_RS05585	COG0693	protein deglycase activity
LAD79_RS05610	COG1764	response to oxidative stress
LAD79_RS05615	COG0384	phenazine biosynthesis protein PhzF
LAD79_RS05620	COG0384	phenazine biosynthesis protein PhzF
LAD79_RS05625	COG0527	aspartate kinase activity
LAD79_RS05650	COG0142	geranyltranstransferase activity
LAD79_RS05655	COG0366	Alpha amylase catalytic
LAD79_RS05665	COG1082	Xylose isomerase domain protein TIM barrel
LAD79_RS05675	COG2211	Major facilitator Superfamily
LAD79_RS05675	COG2190	(PTS) system
LAD79_RS05715	COG1131	(ABC) transporter
LAD79_RS05725	COG0629	single-stranded DNA binding
LAD79_RS05790	COG0673	inositol 2-dehydrogenase activity
LAD79_RS05795	COG2211	Major facilitator Superfamily
LAD79_RS05805	COG1609	Transcriptional regulator
LAD79_RS05845	COG0640	Transcriptional regulator
LAD79_RS05860	COG3655	Transcriptional regulator
LAD79_RS05865	COG1253	flavin adenine dinucleotide binding
LAD79_RS05870	COG1408	metallophosphoesterase
LAD79_RS05875	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LAD79_RS05895	COG2259	Doxx family
LAD79_RS05925	COG0477	Major facilitator Superfamily
LAD79_RS05940	COG1802	Transcriptional regulator
LAD79_RS05975	COG3052	prosthetic group binding
LAD79_RS05990	COG0579	oxidoreductase
LAD79_RS06015	COG3104	oligopeptide transport
LAD79_RS06035	COG1297	OPT oligopeptide transporter protein
LAD79_RS06040	COG1506	peptidase
LAD79_RS06040	COG0823	Involved in the tonB-independent uptake of proteins
LAD79_RS06055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LAD79_RS06060	COG2894	cell division
LAD79_RS06075	COG4585	Histidine kinase
LAD79_RS06080	COG2197	response regulator
LAD79_RS06120	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LAD79_RS06130	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LAD79_RS06140	COG1595	DNA-templated transcription, initiation
LAD79_RS06150	COG1946	Acyl-CoA thioesterase
LAD79_RS06170	COG0824	Thioesterase
LAD79_RS06175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LAD79_RS06180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LAD79_RS06185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LAD79_RS06190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LAD79_RS06195	COG0268	Binds directly to 16S ribosomal RNA
LAD79_RS06200	COG0728	peptidoglycan biosynthetic process
LAD79_RS06205	COG0196	riboflavin kinase activity
LAD79_RS06210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LAD79_RS06220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LAD79_RS06245	COG4206	TonB-dependent receptor
LAD79_RS06265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LAD79_RS06275	COG3209	COG3209 Rhs family protein
LAD79_RS06310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LAD79_RS06315	COG1845	cytochrome c oxidase, subunit III
LAD79_RS06320	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LAD79_RS06335	COG0326	Molecular chaperone. Has ATPase activity
LAD79_RS06355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LAD79_RS06370	COG0228	four-way junction DNA binding
LAD79_RS06375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LAD79_RS06380	COG0336	Belongs to the RNA methyltransferase TrmD family
LAD79_RS06385	COG0335	large ribosomal subunit rRNA binding
LAD79_RS06405	COG0534	Mate efflux family protein
LAD79_RS06425	COG0753	catalase activity
LAD79_RS06535	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LAD79_RS06590	COG0784	Response regulator, receiver
LAD79_RS06590	COG4191	Histidine kinase
LAD79_RS06605	COG3685	Protein conserved in bacteria
LAD79_RS06640	COG1012	belongs to the aldehyde dehydrogenase family
LAD79_RS06645	COG1309	transcriptional regulator
LAD79_RS06780	COG1192	Involved in chromosome partitioning
LAD79_RS06855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LAD79_RS06880	COG4735	regulation of single-species biofilm formation
LAD79_RS06895	COG3210	domain, Protein
LAD79_RS06945	COG0840	transmembrane signaling receptor activity
LAD79_RS06965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS06985	COG0024	Methionine aminopeptidase
LAD79_RS07010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LAD79_RS07035	COG1647	Serine aminopeptidase, S33
LAD79_RS07060	COG2814	Major facilitator Superfamily
LAD79_RS07065	COG3706	GGDEF domain
LAD79_RS07090	COG0588	phosphoglycerate mutase activity
LAD79_RS07095	COG3590	peptidase
LAD79_RS07105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LAD79_RS07115	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LAD79_RS07120	COG0745	RESPONSE REGULATOR receiver
LAD79_RS07125	COG2205	protein histidine kinase activity
LAD79_RS07130	COG4452	Inner membrane protein CreD
LAD79_RS07145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LAD79_RS07150	COG0735	belongs to the Fur family
LAD79_RS07190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LAD79_RS07245	COG5001	Diguanylate cyclase
LAD79_RS07245	COG5002	protein histidine kinase activity
LAD79_RS07255	COG1187	pseudouridine synthase activity
LAD79_RS07265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LAD79_RS07290	COG1132	(ABC) transporter
LAD79_RS07340	COG1695	Transcriptional regulator
LAD79_RS07360	COG1981	membrane
LAD79_RS07365	COG0825	malonyl-CoA metabolic process
LAD79_RS07390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LAD79_RS07400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LAD79_RS07405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LAD79_RS07410	COG0750	zinc metalloprotease
LAD79_RS07415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LAD79_RS07420	COG0575	Belongs to the CDS family
LAD79_RS07425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LAD79_RS07430	COG0233	cytoplasmic translational termination
LAD79_RS07435	COG0528	UMP kinase activity
LAD79_RS07445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LAD79_RS07450	COG0052	Belongs to the universal ribosomal protein uS2 family
LAD79_RS07490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LAD79_RS07500	COG1393	Belongs to the ArsC family
LAD79_RS07505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LAD79_RS07510	COG0367	asparagine synthase
LAD79_RS07515	COG0475	glutathione-regulated potassium exporter activity
LAD79_RS07550	COG1566	PFAM secretion protein HlyD family protein
LAD79_RS07555	COG2814	Major facilitator Superfamily
LAD79_RS07570	COG0583	DNA-binding transcription factor activity
LAD79_RS07590	COG0557	exoribonuclease II activity
LAD79_RS07600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LAD79_RS07605	COG1538	Outer membrane efflux protein
LAD79_RS07610	COG0577	efflux transmembrane transporter activity
LAD79_RS07610	COG1136	(ABC) transporter
LAD79_RS07615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS07635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LAD79_RS07640	COG2259	Doxx family
LAD79_RS07650	COG3220	belongs to the UPF0276 family
LAD79_RS07660	COG0704	Plays a role in the regulation of phosphate uptake
LAD79_RS07670	COG0581	inorganic phosphate transmembrane transporter activity
LAD79_RS07675	COG0573	inorganic phosphate transmembrane transporter activity
LAD79_RS07680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LAD79_RS07685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LAD79_RS07695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LAD79_RS07705	COG1024	Enoyl-CoA hydratase
LAD79_RS07715	COG0494	nUDIX hydrolase
LAD79_RS07735	COG0116	Belongs to the methyltransferase superfamily
LAD79_RS07735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LAD79_RS07755	COG2733	membrane
LAD79_RS07765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LAD79_RS07770	COG1012	belongs to the aldehyde dehydrogenase family
LAD79_RS07780	COG0477	Major facilitator Superfamily
LAD79_RS07785	COG2703	oxygen carrier activity
LAD79_RS07805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LAD79_RS07810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LAD79_RS07815	COG0174	glutamine synthetase
LAD79_RS07825	COG2072	flavoprotein involved in K transport
LAD79_RS07830	COG3842	ATPase activity
LAD79_RS07835	COG1176	ABC-type spermidine putrescine transport system, permease component I
LAD79_RS07840	COG1177	transmembrane transport
LAD79_RS07845	COG1012	belongs to the aldehyde dehydrogenase family
LAD79_RS07860	COG4535	Mg2 and Co2 transporter CorC
LAD79_RS07880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LAD79_RS07885	COG1702	phosphate starvation-inducible protein PhoH
LAD79_RS07890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS07895	COG1131	(ABC) transporter
LAD79_RS07900	COG0842	Transport permease protein
LAD79_RS07905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LAD79_RS07920	COG0741	lytic transglycosylase activity
LAD79_RS07925	COG0723	plastoquinol--plastocyanin reductase activity
LAD79_RS07930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LAD79_RS07935	COG2857	Cytochrome c1
LAD79_RS07940	COG0625	glutathione transferase activity
LAD79_RS07945	COG2969	positive regulation of protein catabolic process
LAD79_RS07980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LAD79_RS07990	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LAD79_RS08005	COG1611	Belongs to the LOG family
LAD79_RS08045	COG4970	Tfp pilus assembly protein FimT
LAD79_RS08050	COG0556	nucleotide-excision repair
LAD79_RS08090	COG3713	MltA-interacting MipA family protein
LAD79_RS08110	COG0811	peptide transport
LAD79_RS08125	COG1663	tetraacyldisaccharide 4'-kinase activity
LAD79_RS08130	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LAD79_RS08135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LAD79_RS08145	COG0322	excinuclease ABC activity
LAD79_RS08180	COG1136	(ABC) transporter
LAD79_RS08180	COG0577	efflux transmembrane transporter activity
LAD79_RS08240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LAD79_RS08265	COG0583	DNA-binding transcription factor activity
LAD79_RS08285	COG1917	Cupin 2, conserved barrel domain protein
LAD79_RS08285	COG4977	sequence-specific DNA binding
LAD79_RS08290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LAD79_RS08310	COG0348	domain, Protein
LAD79_RS08325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LAD79_RS08340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LAD79_RS08345	COG0069	glutamate synthase activity
LAD79_RS08370	COG1054	Belongs to the UPF0176 family
LAD79_RS08375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LAD79_RS08390	COG1253	flavin adenine dinucleotide binding
LAD79_RS08410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LAD79_RS08425	COG0504	CTP synthase activity
LAD79_RS08430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LAD79_RS08445	COG0148	phosphopyruvate hydratase activity
LAD79_RS08450	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LAD79_RS08455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LAD79_RS08460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LAD79_RS08470	COG2840	Smr protein MutS2
LAD79_RS08475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LAD79_RS08480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LAD79_RS08505	COG1534	Rna-binding protein
LAD79_RS08510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LAD79_RS08515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LAD79_RS08530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LAD79_RS08535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LAD79_RS08540	COG1923	regulation of RNA biosynthetic process
LAD79_RS08545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LAD79_RS08550	COG1546	Belongs to the CinA family
LAD79_RS08555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LAD79_RS08560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LAD79_RS08565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LAD79_RS08570	COG2137	regulation of response to DNA damage stimulus
LAD79_RS08575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LAD79_RS08580	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LAD79_RS08630	COG3540	Alkaline phosphatase
LAD79_RS08645	COG3258	Cytochrome c
LAD79_RS08660	COG2223	nitrite transmembrane transporter activity
LAD79_RS08675	COG1741	Belongs to the pirin family
LAD79_RS08680	COG0583	DNA-binding transcription factor activity
LAD79_RS08715	COG0351	phosphomethylpyrimidine kinase
LAD79_RS08715	COG0352	thiamine-phosphate diphosphorylase activity
LAD79_RS08730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LAD79_RS08735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LAD79_RS08745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LAD79_RS08755	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LAD79_RS08760	COG0477	Major facilitator Superfamily
LAD79_RS08770	COG0617	tRNA 3'-terminal CCA addition
LAD79_RS08775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LAD79_RS08780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LAD79_RS08785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LAD79_RS08795	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LAD79_RS08800	COG0166	Belongs to the GPI family
LAD79_RS08805	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LAD79_RS08815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LAD79_RS08820	COG0671	phosphoesterase, PA-phosphatase related
LAD79_RS08830	COG0800	Aldolase
LAD79_RS08835	COG0129	dihydroxy-acid dehydratase activity
LAD79_RS08845	COG0837	glucose binding
LAD79_RS08870	COG2009	succinate dehydrogenase
LAD79_RS08875	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LAD79_RS08880	COG1053	succinate dehydrogenase
LAD79_RS08900	COG4591	ABC-type transport system involved in lipoprotein release permease component
LAD79_RS08915	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LAD79_RS08925	COG0552	protein localization to endoplasmic reticulum
LAD79_RS08940	COG0742	ribosomal rna small subunit methyltransferase
LAD79_RS08945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LAD79_RS08955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LAD79_RS08960	COG0405	Gamma-glutamyltransferase
LAD79_RS08965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LAD79_RS08985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LAD79_RS09005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LAD79_RS09015	COG0415	Belongs to the DNA photolyase family
LAD79_RS09020	COG2885	chlorophyll binding
LAD79_RS09025	COG0583	DNA-binding transcription factor activity
LAD79_RS09130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LAD79_RS09140	COG2914	Belongs to the UPF0125 (RnfH) family
LAD79_RS09145	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LAD79_RS09150	COG0735	belongs to the Fur family
LAD79_RS09160	COG0583	DNA-binding transcription factor activity
LAD79_RS09165	COG0497	DNA recombination
LAD79_RS09170	COG1420	regulation of RNA biosynthetic process
LAD79_RS09175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LAD79_RS09180	COG0443	Heat shock 70 kDa protein
LAD79_RS09185	COG0484	heat shock protein binding
LAD79_RS09190	COG2207	Transcriptional regulator
LAD79_RS09195	COG2223	nitrite transmembrane transporter activity
LAD79_RS09200	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LAD79_RS09205	COG1605	Chorismate mutase
LAD79_RS09205	COG0287	Prephenate dehydrogenase
LAD79_RS09215	COG1132	(ABC) transporter
LAD79_RS09245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LAD79_RS09250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LAD79_RS09255	COG0343	queuine tRNA-ribosyltransferase activity
LAD79_RS09260	COG1862	Preprotein translocase
LAD79_RS09270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LAD79_RS09275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LAD79_RS09285	COG2081	HI0933 family
LAD79_RS09290	COG4681	YaeQ
LAD79_RS09310	COG0625	glutathione transferase activity
LAD79_RS09315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LAD79_RS09320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LAD79_RS09325	COG0513	Belongs to the DEAD box helicase family
LAD79_RS09335	COG0583	DNA-binding transcription factor activity
LAD79_RS09340	COG0488	(ABC) transporter
LAD79_RS09365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAD79_RS09380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LAD79_RS09385	COG2957	Belongs to the agmatine deiminase family
LAD79_RS09395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LAD79_RS09400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LAD79_RS09410	COG0776	regulation of translation
LAD79_RS09420	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LAD79_RS09425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LAD79_RS09435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LAD79_RS09440	COG0183	Belongs to the thiolase family
LAD79_RS09445	COG1024	Enoyl-CoA hydratase
LAD79_RS09445	COG1250	3-hydroxyacyl-CoA dehydrogenase
LAD79_RS09455	COG0105	UTP biosynthetic process
LAD79_RS09460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LAD79_RS09465	COG0859	PFAM glycosyl transferase family 9
LAD79_RS09465	COG0457	Tetratricopeptide repeat
LAD79_RS09470	COG1426	Protein conserved in bacteria
LAD79_RS09470	COG1426	Protein conserved in bacteria
LAD79_RS09480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LAD79_RS09485	COG1160	GTP binding
LAD79_RS09505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LAD79_RS09510	COG0475	glutathione-regulated potassium exporter activity
LAD79_RS09510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LAD79_RS09525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LAD79_RS09525	COG0519	Catalyzes the synthesis of GMP from XMP
LAD79_RS09555	COG0583	DNA-binding transcription factor activity
LAD79_RS09575	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS09600	COG0640	Transcriptional regulator
LAD79_RS09615	COG4716	Myosin-crossreactive antigen
LAD79_RS09645	COG3415	Transposase
LAD79_RS09645	COG2801	Transposase and inactivated derivatives
LAD79_RS09650	COG4206	TonB-dependent receptor
LAD79_RS09655	COG0431	NADPH-dependent FMN reductase
LAD79_RS09665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LAD79_RS09670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LAD79_RS09675	COG1473	amidohydrolase
LAD79_RS09690	COG1126	abc transporter atp-binding protein
LAD79_RS09695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAD79_RS09720	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LAD79_RS09725	COG0583	DNA-binding transcription factor activity
LAD79_RS09730	COG0477	Major facilitator Superfamily
LAD79_RS09735	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS09745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LAD79_RS09765	COG1309	transcriptional regulator
LAD79_RS09780	COG0697	spore germination
LAD79_RS09785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LAD79_RS09790	COG0167	dihydroorotate dehydrogenase activity
LAD79_RS09805	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS09810	COG1012	belongs to the aldehyde dehydrogenase family
LAD79_RS09990	COG0745	RESPONSE REGULATOR receiver
LAD79_RS09995	COG4191	Histidine kinase
LAD79_RS09995	COG0784	Response regulator, receiver
LAD79_RS10000	COG3437	response regulator, receiver
LAD79_RS10000	COG4999	Histidine kinase
LAD79_RS10000	COG3850	Histidine kinase
LAD79_RS10000	COG2205	protein histidine kinase activity
LAD79_RS10005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LAD79_RS10020	COG0640	Transcriptional regulator
LAD79_RS10060	COG0460	homoserine dehydrogenase
LAD79_RS10060	COG0527	aspartate kinase activity
LAD79_RS10065	COG0083	homoserine kinase activity
LAD79_RS10075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAD79_RS10080	COG0124	histidyl-tRNA synthetase
LAD79_RS10095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LAD79_RS10100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LAD79_RS10105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LAD79_RS10110	COG0131	Imidazoleglycerol-phosphate dehydratase
LAD79_RS10110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LAD79_RS10115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LAD79_RS10120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LAD79_RS10125	COG0107	imidazoleglycerol-phosphate synthase activity
LAD79_RS10130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LAD79_RS10130	COG0140	phosphoribosyl-ATP diphosphatase activity
LAD79_RS10150	COG1446	asparaginase
LAD79_RS10155	COG3142	Participates in the control of copper homeostasis
LAD79_RS10170	COG0789	Transcriptional regulator
LAD79_RS10190	COG3537	Alpha-1,2-mannosidase
LAD79_RS10195	COG1609	Transcriptional regulator
LAD79_RS10205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAD79_RS10220	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LAD79_RS10225	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LAD79_RS10230	COG0235	Class ii aldolase
LAD79_RS10245	COG0531	amino acid
LAD79_RS10250	COG0531	amino acid
LAD79_RS10260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LAD79_RS10265	COG0277	FAD linked oxidase domain protein
LAD79_RS10280	COG2205	protein histidine kinase activity
LAD79_RS10285	COG0745	RESPONSE REGULATOR receiver
LAD79_RS10290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS10310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LAD79_RS10355	COG2249	NAD(P)H dehydrogenase (quinone) activity
LAD79_RS10370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LAD79_RS10375	COG0505	Belongs to the CarA family
LAD79_RS10380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LAD79_RS10385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LAD79_RS10400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LAD79_RS10405	COG4676	Protein conserved in bacteria
LAD79_RS10450	COG1012	belongs to the aldehyde dehydrogenase family
LAD79_RS10470	COG2198	Histidine kinase
LAD79_RS10470	COG2205	protein histidine kinase activity
LAD79_RS10470	COG0784	Response regulator, receiver
LAD79_RS10475	COG1024	Enoyl-CoA hydratase
LAD79_RS10480	COG0318	PFAM AMP-dependent synthetase and ligase
LAD79_RS10485	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LAD79_RS10490	COG1012	belongs to the aldehyde dehydrogenase family
LAD79_RS10495	COG1309	transcriptional regulator
LAD79_RS10500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LAD79_RS10545	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LAD79_RS10555	COG0840	transmembrane signaling receptor activity
LAD79_RS10570	COG0840	transmembrane signaling receptor activity
LAD79_RS10580	COG0835	chemotaxis
LAD79_RS10585	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LAD79_RS10590	COG0840	transmembrane signaling receptor activity
LAD79_RS10600	COG0745	RESPONSE REGULATOR receiver
LAD79_RS10610	COG0835	chemotaxis
LAD79_RS10620	COG1360	Flagellar Motor Protein
LAD79_RS10625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LAD79_RS10630	COG0643	Histidine kinase
LAD79_RS10630	COG0784	Response regulator, receiver
LAD79_RS10630	COG2198	Histidine kinase
LAD79_RS10635	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LAD79_RS10660	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LAD79_RS10665	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LAD79_RS10685	COG1987	bacterial-type flagellum assembly
LAD79_RS10695	COG3190	flagellar
LAD79_RS10745	COG1677	Flagellar hook-basal body complex protein FliE
LAD79_RS10775	COG2197	response regulator
LAD79_RS10795	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LAD79_RS10800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LAD79_RS10840	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LAD79_RS10850	COG4787	bacterial-type flagellum-dependent cell motility
LAD79_RS10865	COG1558	bacterial-type flagellum-dependent cell motility
LAD79_RS10870	COG1815	bacterial-type flagellum-dependent cell motility
LAD79_RS10875	COG0835	chemotaxis
LAD79_RS10875	COG0784	Response regulator, receiver
LAD79_RS10895	COG5002	protein histidine kinase activity
LAD79_RS10940	COG2915	High frequency lysogenization protein hflD homolog
LAD79_RS10945	COG0482	sulfurtransferase activity
LAD79_RS10960	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LAD79_RS10970	COG0542	response to heat
LAD79_RS11000	COG0492	ferredoxin-NADP+ reductase activity
LAD79_RS11005	COG1674	ftsk spoiiie
LAD79_RS11020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LAD79_RS11035	COG2819	hydrolase of the alpha beta superfamily
LAD79_RS11045	COG4558	Periplasmic binding protein
LAD79_RS11050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LAD79_RS11055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LAD79_RS11065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LAD79_RS11100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LAD79_RS11110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LAD79_RS11120	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LAD79_RS11135	COG1595	DNA-templated transcription, initiation
LAD79_RS11155	COG0784	Response regulator, receiver
LAD79_RS11160	COG4251	negative regulation of phosphorylation
LAD79_RS11170	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LAD79_RS11205	COG3546	catalase activity
LAD79_RS11210	COG3685	Protein conserved in bacteria
LAD79_RS11235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LAD79_RS11255	COG1063	alcohol dehydrogenase
LAD79_RS11285	COG1609	Transcriptional regulator
LAD79_RS11290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAD79_RS11290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LAD79_RS11295	COG1105	Belongs to the carbohydrate kinase PfkB family
LAD79_RS11300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAD79_RS11300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAD79_RS11315	COG1733	regulation of RNA biosynthetic process
LAD79_RS11320	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LAD79_RS11330	COG4771	TonB-dependent receptor
LAD79_RS11335	COG0738	Major facilitator superfamily
LAD79_RS11340	COG1609	Transcriptional regulator
LAD79_RS11360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LAD79_RS11375	COG2828	Protein conserved in bacteria
LAD79_RS11380	COG0583	DNA-binding transcription factor activity
LAD79_RS11405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LAD79_RS11410	COG0583	DNA-binding transcription factor activity
LAD79_RS11440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LAD79_RS11465	COG0642	Histidine kinase
LAD79_RS11475	COG0318	PFAM AMP-dependent synthetase and ligase
LAD79_RS11490	COG2186	Transcriptional regulator
LAD79_RS11510	COG2271	Major facilitator Superfamily
LAD79_RS11515	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS11525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAD79_RS11550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LAD79_RS11570	COG0583	DNA-binding transcription factor activity
LAD79_RS11595	COG2204	response regulator
LAD79_RS11675	COG0708	Exodeoxyribonuclease III
LAD79_RS11680	COG0366	Alpha amylase catalytic
LAD79_RS11685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LAD79_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS11705	COG0577	efflux transmembrane transporter activity
LAD79_RS11705	COG1136	(ABC) transporter
LAD79_RS11710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS11720	COG0745	RESPONSE REGULATOR receiver
LAD79_RS11725	COG2205	protein histidine kinase activity
LAD79_RS11735	COG3214	Protein conserved in bacteria
LAD79_RS11745	COG4774	siderophore transport
LAD79_RS11765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LAD79_RS11770	COG1285	pathogenesis
LAD79_RS11775	COG4191	Histidine kinase
LAD79_RS11780	COG4566	intracellular signal transduction
LAD79_RS11840	COG0243	molybdopterin cofactor binding
LAD79_RS11865	COG0477	Major facilitator Superfamily
LAD79_RS11890	COG1136	(ABC) transporter
LAD79_RS11905	COG0583	DNA-binding transcription factor activity
LAD79_RS11910	COG0656	L-ascorbic acid biosynthetic process
LAD79_RS11930	COG2372	response to copper ion
LAD79_RS11945	COG5002	protein histidine kinase activity
LAD79_RS11950	COG0583	DNA-binding transcription factor activity
LAD79_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS11980	COG0642	Histidine kinase
LAD79_RS11985	COG3537	Alpha-1,2-mannosidase
LAD79_RS12000	COG0477	Major facilitator Superfamily
LAD79_RS12020	COG3920	Histidine kinase
LAD79_RS12020	COG2202	Pas domain
LAD79_RS12065	COG1335	isochorismatase
LAD79_RS12070	COG1335	isochorismatase
LAD79_RS12100	COG0811	peptide transport
LAD79_RS12240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LAD79_RS12245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LAD79_RS12255	COG0840	transmembrane signaling receptor activity
LAD79_RS12260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LAD79_RS12265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LAD79_RS12270	COG4149	molybdate abc transporter
LAD79_RS12275	COG0725	ABC transporter, periplasmic molybdate-binding protein
LAD79_RS12280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAD79_RS12295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LAD79_RS12300	COG2181	nitrate reductase activity
LAD79_RS12305	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LAD79_RS12310	COG1140	nitrate reductase beta subunit
LAD79_RS12315	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LAD79_RS12320	COG2223	nitrite transmembrane transporter activity
LAD79_RS12330	COG0746	molybdenum cofactor guanylyltransferase activity
LAD79_RS12335	COG0314	molybdopterin synthase activity
LAD79_RS12345	COG0303	'Molybdopterin
LAD79_RS12350	COG0315	cyclic pyranopterin monophosphate synthase activity
LAD79_RS12350	COG0521	Mo-molybdopterin cofactor biosynthetic process
LAD79_RS12355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LAD79_RS12415	COG2207	Transcriptional regulator
LAD79_RS12455	COG2205	protein histidine kinase activity
LAD79_RS12465	COG2194	sulfuric ester hydrolase activity
LAD79_RS12485	COG2885	chlorophyll binding
LAD79_RS12500	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS12505	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LAD79_RS12505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LAD79_RS12510	COG3433	isochorismatase activity
LAD79_RS12510	COG1535	isochorismatase
LAD79_RS12515	COG3433	isochorismatase activity
LAD79_RS12515	COG1535	isochorismatase
LAD79_RS12520	COG1021	2,3-dihydroxybenzoate-AMP ligase
LAD79_RS12525	COG1169	isochorismate synthase
LAD79_RS12535	COG2409	Drug exporters of the RND superfamily
LAD79_RS12540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LAD79_RS12600	COG4771	TonB-dependent receptor
LAD79_RS12615	COG1914	H( )-stimulated, divalent metal cation uptake system
LAD79_RS12630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAD79_RS12635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAD79_RS12640	COG0604	alcohol dehydrogenase
LAD79_RS12640	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS12640	COG3321	synthase
LAD79_RS12650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LAD79_RS12695	COG4772	TonB-dependent receptor
LAD79_RS12715	COG2226	methyltransferase
LAD79_RS12760	COG4964	Belongs to the GSP D family
LAD79_RS12815	COG2814	Major facilitator Superfamily
LAD79_RS12825	COG1228	amidohydrolase
LAD79_RS12835	COG1335	isochorismatase
LAD79_RS12850	COG3850	Histidine kinase
LAD79_RS12855	COG2197	response regulator
LAD79_RS12860	COG2814	Major facilitator Superfamily
LAD79_RS12880	COG0583	DNA-binding transcription factor activity
LAD79_RS12895	COG3161	chorismate lyase activity
LAD79_RS12935	COG0277	FAD linked oxidase domain protein
LAD79_RS12940	COG1304	FMN binding
LAD79_RS12945	COG2186	Transcriptional regulator
LAD79_RS12955	COG1285	pathogenesis
LAD79_RS12980	COG2814	Major facilitator Superfamily
LAD79_RS13035	COG0587	DNA-directed DNA polymerase activity
LAD79_RS13050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LAD79_RS13055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LAD79_RS13055	COG0519	Catalyzes the synthesis of GMP from XMP
LAD79_RS13070	COG1595	DNA-templated transcription, initiation
LAD79_RS13080	COG1629	transport
LAD79_RS13080	COG4206	TonB-dependent receptor
LAD79_RS13110	COG0531	amino acid
LAD79_RS13125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LAD79_RS13135	COG0789	Transcriptional regulator
LAD79_RS13220	COG5001	Diguanylate cyclase
LAD79_RS13220	COG5002	protein histidine kinase activity
LAD79_RS13220	COG3447	MASE1 domain protein
LAD79_RS13225	COG2183	response to ionizing radiation
LAD79_RS13240	COG1983	PspC domain protein
LAD79_RS13250	COG3243	poly(R)-hydroxyalkanoic acid synthase
LAD79_RS13270	COG0534	Mate efflux family protein
LAD79_RS13290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LAD79_RS13300	COG0668	transmembrane transport
LAD79_RS13305	COG1902	pentaerythritol trinitrate reductase activity
LAD79_RS13325	COG1733	regulation of RNA biosynthetic process
LAD79_RS13330	COG2249	NAD(P)H dehydrogenase (quinone) activity
LAD79_RS13335	COG0456	acetyltransferase
LAD79_RS13410	COG3702	type iv secretory pathway
LAD79_RS13430	COG2948	multi-organism process
LAD79_RS13440	COG3736	Type IV secretory pathway, component VirB8
LAD79_RS13450	COG3505	Type IV secretory pathway VirD4
LAD79_RS13465	COG2814	Major facilitator Superfamily
LAD79_RS13470	COG0789	Transcriptional regulator
LAD79_RS13505	COG0784	Response regulator, receiver
LAD79_RS13505	COG4191	Histidine kinase
LAD79_RS13520	COG4774	siderophore transport
LAD79_RS13540	COG1733	regulation of RNA biosynthetic process
LAD79_RS13545	COG0604	alcohol dehydrogenase
LAD79_RS13560	COG0210	DNA helicase
LAD79_RS13570	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LAD79_RS13570	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LAD79_RS13595	COG0583	DNA-binding transcription factor activity
LAD79_RS13600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LAD79_RS13610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LAD79_RS13625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LAD79_RS13630	COG0077	Prephenate dehydratase
LAD79_RS13630	COG1605	Chorismate mutase
LAD79_RS13635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LAD79_RS13680	COG1228	amidohydrolase
LAD79_RS13695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LAD79_RS13745	COG2957	Belongs to the agmatine deiminase family
LAD79_RS13750	COG0583	DNA-binding transcription factor activity
LAD79_RS13795	COG2801	Transposase and inactivated derivatives
LAD79_RS13795	COG3415	Transposase
LAD79_RS13805	COG3415	Transposase
LAD79_RS13805	COG2801	Transposase and inactivated derivatives
LAD79_RS13810	COG4993	Dehydrogenase
LAD79_RS13820	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LAD79_RS13830	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LAD79_RS13840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LAD79_RS13845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LAD79_RS13860	COG0359	binds to the 23S rRNA
LAD79_RS13865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LAD79_RS13870	COG0360	Binds together with S18 to 16S ribosomal RNA
LAD79_RS13880	COG0316	Belongs to the HesB IscA family
LAD79_RS13885	COG0017	Asparaginyl-tRNA synthetase
LAD79_RS13905	COG0288	reversible hydration of carbon dioxide
LAD79_RS13915	COG3844	kynureninase activity
LAD79_RS13920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LAD79_RS13925	COG2925	Exonuclease
LAD79_RS13950	COG2902	Dehydrogenase
LAD79_RS13960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS13965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAD79_RS13980	COG1960	acyl-CoA dehydrogenase activity
LAD79_RS13985	COG2226	methyltransferase
LAD79_RS13995	COG0646	methionine synthase
LAD79_RS13995	COG1410	methionine synthase
LAD79_RS14010	COG2900	Belongs to the SlyX family
LAD79_RS14025	COG0386	Belongs to the glutathione peroxidase family
LAD79_RS14035	COG1725	Transcriptional regulator
LAD79_RS14040	COG1131	(ABC) transporter
LAD79_RS14065	COG0114	fumarate hydratase activity
LAD79_RS14075	COG2850	peptidyl-arginine hydroxylation
LAD79_RS14085	COG0567	Dehydrogenase, E1 component
LAD79_RS14110	COG3540	Alkaline phosphatase
LAD79_RS14120	COG0305	Participates in initiation and elongation during chromosome replication
LAD79_RS14140	COG0625	glutathione transferase activity
LAD79_RS14160	COG0084	hydrolase, TatD family'
LAD79_RS14165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LAD79_RS14200	COG0625	glutathione transferase activity
LAD79_RS14215	COG1595	DNA-templated transcription, initiation
LAD79_RS14220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LAD79_RS14235	COG0386	Belongs to the glutathione peroxidase family
LAD79_RS14240	COG0339	signal peptide processing
LAD79_RS14250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LAD79_RS14270	COG0705	Rhomboid family
LAD79_RS14275	COG3104	oligopeptide transport
LAD79_RS14285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LAD79_RS14290	COG4290	ribonuclease
LAD79_RS14305	COG0316	Belongs to the HesB IscA family
LAD79_RS14305	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LAD79_RS14310	COG2154	pterin-4-alpha-carbinolamine dehydratase
LAD79_RS14320	COG0428	transporter
LAD79_RS14330	COG1530	ribonuclease E activity
LAD79_RS14345	COG0395	ABC-type sugar transport system, permease component
LAD79_RS14375	COG0271	Belongs to the BolA IbaG family
LAD79_RS14380	COG2350	Protein conserved in bacteria
LAD79_RS14385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LAD79_RS14390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LAD79_RS14395	COG1187	pseudouridine synthase activity
LAD79_RS14405	COG2814	Major facilitator Superfamily
LAD79_RS14425	COG0436	Aminotransferase
LAD79_RS14430	COG4133	protoheme IX ABC transporter activity
LAD79_RS14450	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LAD79_RS14465	COG3088	subunit of a heme lyase
LAD79_RS14465	COG4235	cytochrome complex assembly
LAD79_RS14475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LAD79_RS14485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LAD79_RS14490	COG4988	ABC transporter
LAD79_RS14500	COG1294	oxidase, subunit
LAD79_RS14530	COG1649	PFAM Uncharacterised BCR, COG1649
LAD79_RS14530	COG0726	polysaccharide deacetylase
LAD79_RS14535	COG1215	transferase activity, transferring glycosyl groups
LAD79_RS14545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LAD79_RS14560	COG0165	Argininosuccinate lyase
LAD79_RS14565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LAD79_RS14575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LAD79_RS14580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LAD79_RS14585	COG0137	argininosuccinate synthase activity
LAD79_RS14590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LAD79_RS14605	COG2166	iron-sulfur cluster assembly
LAD79_RS14625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LAD79_RS14645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LAD79_RS14650	COG0402	S-adenosylhomocysteine deaminase activity
LAD79_RS14655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LAD79_RS14660	COG1509	lysine 2,3-aminomutase activity
LAD79_RS14665	COG3300	MHYT domain
LAD79_RS14665	COG5001	Diguanylate cyclase
LAD79_RS14685	COG0501	Belongs to the peptidase M48B family
LAD79_RS14695	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS14715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LAD79_RS14720	COG0860	N-Acetylmuramoyl-L-alanine amidase
LAD79_RS14725	COG0802	atpase or kinase
LAD79_RS14730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LAD79_RS14730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LAD79_RS14735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LAD79_RS14740	COG1570	exodeoxyribonuclease VII activity
LAD79_RS14750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LAD79_RS14770	COG4771	TonB-dependent receptor
LAD79_RS14795	COG2169	Transcriptional regulator
LAD79_RS14795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LAD79_RS14800	COG2130	NADP-dependent
LAD79_RS14825	COG1960	acyl-CoA dehydrogenase activity
LAD79_RS14835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LAD79_RS14870	COG2076	Multidrug Resistance protein
LAD79_RS14875	COG5487	UPF0391 membrane protein
LAD79_RS14880	COG1280	lysine exporter protein (LysE YggA)
LAD79_RS14885	COG1794	racemase activity, acting on amino acids and derivatives
LAD79_RS14920	COG0776	regulation of translation
LAD79_RS14925	COG0072	phenylalanine-tRNA ligase activity
LAD79_RS14925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAD79_RS14930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LAD79_RS14935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LAD79_RS14940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LAD79_RS14945	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LAD79_RS14950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LAD79_RS14985	COG1185	polyribonucleotide nucleotidyltransferase activity
LAD79_RS14990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LAD79_RS15000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LAD79_RS15005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LAD79_RS15010	COG0195	Participates in both transcription termination and antitermination
LAD79_RS15015	COG0779	Required for maturation of 30S ribosomal subunits
LAD79_RS15030	COG1007	ATP synthesis coupled electron transport
LAD79_RS15045	COG0713	ATP synthesis coupled electron transport
LAD79_RS15055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAD79_RS15060	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LAD79_RS15075	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LAD79_RS15080	COG0649	NAD binding
LAD79_RS15085	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAD79_RS15090	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAD79_RS15095	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAD79_RS15110	COG0149	triose-phosphate isomerase activity
LAD79_RS15120	COG3083	sulfuric ester hydrolase activity
LAD79_RS15125	COG0438	transferase activity, transferring glycosyl groups
LAD79_RS15130	COG0726	polysaccharide deacetylase
LAD79_RS15135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LAD79_RS15140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LAD79_RS15145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LAD79_RS15150	COG0159	tryptophan synthase activity
LAD79_RS15160	COG0133	tryptophan synthase activity
LAD79_RS15180	COG0135	phosphoribosylanthranilate isomerase activity
LAD79_RS15185	COG0101	tRNA pseudouridine synthase activity
LAD79_RS15200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LAD79_RS15205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LAD79_RS15210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LAD79_RS15215	COG2890	protein-(glutamine-N5) methyltransferase activity
LAD79_RS15220	COG1999	signal sequence binding
LAD79_RS15225	COG0688	phosphatidylethanolamine metabolic process
LAD79_RS15240	COG0433	COG0433 Predicted ATPase
LAD79_RS15245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LAD79_RS15255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LAD79_RS15260	COG0412	Dienelactone hydrolase
LAD79_RS15275	COG0717	Belongs to the dCTP deaminase family
LAD79_RS15280	COG0489	protein tyrosine kinase activity
LAD79_RS15285	COG4771	TonB-dependent receptor
LAD79_RS15295	COG4771	TonB-dependent receptor
LAD79_RS15305	COG3590	peptidase
LAD79_RS15310	COG2801	Transposase and inactivated derivatives
LAD79_RS15310	COG3415	Transposase
LAD79_RS15345	COG0697	spore germination
LAD79_RS15355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LAD79_RS15360	COG2311	Membrane
LAD79_RS15365	COG1047	Peptidyl-prolyl cis-trans
LAD79_RS15370	COG0791	NLP P60 protein
LAD79_RS15375	COG0791	NLP P60 protein
LAD79_RS15380	COG1301	dicarboxylic acid transport
LAD79_RS15400	COG1722	exodeoxyribonuclease VII activity
LAD79_RS15405	COG0142	geranyltranstransferase activity
LAD79_RS15415	COG0312	modulator of DNA gyrase
LAD79_RS15420	COG3028	Belongs to the UPF0307 family
LAD79_RS15425	COG0312	modulator of DNA gyrase
LAD79_RS15445	COG2968	Membrane
LAD79_RS15470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LAD79_RS15480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LAD79_RS15495	COG0495	leucyl-tRNA aminoacylation
LAD79_RS15505	COG3118	belongs to the thioredoxin family
LAD79_RS15515	COG2203	Gaf domain
LAD79_RS15515	COG3706	GGDEF domain
LAD79_RS15515	COG4251	negative regulation of phosphorylation
LAD79_RS15515	COG5001	Diguanylate cyclase
LAD79_RS15535	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LAD79_RS15545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LAD79_RS15550	COG0346	lactoylglutathione lyase activity
LAD79_RS15560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAD79_RS15560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAD79_RS15570	COG2878	Part of a membrane complex involved in electron transport
LAD79_RS15575	COG0251	oxidation-reduction process
LAD79_RS15580	COG0392	lysyltransferase activity
LAD79_RS15580	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LAD79_RS15610	COG2824	Alkylphosphonate utilization operon protein PhnA
LAD79_RS15615	COG0443	Heat shock 70 kDa protein
LAD79_RS15655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LAD79_RS15660	COG3122	Protein conserved in bacteria
LAD79_RS15665	COG1451	nucleotide metabolic process
LAD79_RS15675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LAD79_RS15695	COG0183	Belongs to the thiolase family
LAD79_RS15710	COG1960	acyl-CoA dehydrogenase activity
LAD79_RS15720	COG1793	dna ligase
LAD79_RS15725	COG1201	RNA secondary structure unwinding
LAD79_RS15740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LAD79_RS15745	COG1278	Cold shock
LAD79_RS15750	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LAD79_RS15755	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LAD79_RS15760	COG1472	Belongs to the glycosyl hydrolase 3 family
LAD79_RS15765	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LAD79_RS15770	COG2954	triphosphatase activity
LAD79_RS15775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LAD79_RS15780	COG0745	RESPONSE REGULATOR receiver
LAD79_RS15785	COG1381	Involved in DNA repair and RecF pathway recombination
LAD79_RS15790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LAD79_RS15805	COG0681	Belongs to the peptidase S26 family
LAD79_RS15810	COG0481	GTPase activity
LAD79_RS15815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LAD79_RS15835	COG1741	Belongs to the pirin family
LAD79_RS15840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LAD79_RS15850	COG1741	Belongs to the pirin family
LAD79_RS15855	COG1966	Carbon starvation protein
LAD79_RS15860	COG2879	small protein
LAD79_RS15875	COG2205	protein histidine kinase activity
LAD79_RS15915	COG2814	Major facilitator Superfamily
LAD79_RS15920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LAD79_RS15920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LAD79_RS15930	COG1113	amino acid transport
LAD79_RS15935	COG1917	Cupin 2, conserved barrel domain protein
LAD79_RS15935	COG2207	Transcriptional regulator
LAD79_RS15940	COG0753	catalase activity
LAD79_RS15970	COG1376	ErfK ybiS ycfS ynhG family protein
LAD79_RS15975	COG0739	heme binding
LAD79_RS15985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LAD79_RS15995	COG0330	HflC and HflK could
LAD79_RS16000	COG0330	HflC and HflK could
LAD79_RS16005	COG0604	alcohol dehydrogenase
LAD79_RS16020	COG0678	peroxiredoxin activity
LAD79_RS16030	COG4953	penicillin-binding protein 1C
LAD79_RS16035	COG2373	Large extracellular alpha-helical protein
LAD79_RS16040	COG2079	MmgE PrpD family protein
LAD79_RS16045	COG2828	Protein conserved in bacteria
LAD79_RS16055	COG3609	addiction module antidote protein, CC2985 family
LAD79_RS16085	COG0259	pyridoxamine-phosphate oxidase activity
LAD79_RS16100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LAD79_RS16120	COG0477	Major facilitator Superfamily
LAD79_RS16140	COG3038	cytochrome b561
LAD79_RS16155	COG1760	l-serine dehydratase
LAD79_RS16160	COG2267	carboxylic ester hydrolase activity
LAD79_RS16165	COG0527	aspartate kinase activity
LAD79_RS16165	COG0460	homoserine dehydrogenase
LAD79_RS16170	COG0626	cystathionine gamma-synthase activity
LAD79_RS16175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LAD79_RS16180	COG0739	heme binding
LAD79_RS16185	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LAD79_RS16190	COG1272	protein, Hemolysin III
LAD79_RS16205	COG0463	Glycosyl transferase, family 2
LAD79_RS16210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LAD79_RS16215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LAD79_RS16230	COG1309	transcriptional regulator
LAD79_RS16240	COG1960	acyl-CoA dehydrogenase activity
LAD79_RS16275	COG0583	DNA-binding transcription factor activity
LAD79_RS16285	COG0509	glycine decarboxylation via glycine cleavage system
LAD79_RS16290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LAD79_RS16300	COG0330	HflC and HflK could
LAD79_RS16310	COG1742	UPF0060 membrane protein
LAD79_RS16315	COG3956	TIGRFAM MazG family protein
LAD79_RS16325	COG0494	nUDIX hydrolase
LAD79_RS16335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LAD79_RS16355	COG0840	transmembrane signaling receptor activity
LAD79_RS16360	COG0835	chemotaxis
LAD79_RS16375	COG0189	ligase activity
LAD79_RS16385	COG1214	PFAM Peptidase M22, glycoprotease
LAD79_RS16390	COG1199	ATP-dependent helicase activity
LAD79_RS16400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LAD79_RS16405	COG1215	transferase activity, transferring glycosyl groups
LAD79_RS16420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LAD79_RS16430	COG1643	Atp-dependent helicase
LAD79_RS16435	COG0783	Belongs to the Dps family
LAD79_RS16440	COG0514	ATP-dependent DNA helicase (RecQ)
LAD79_RS16505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LAD79_RS16510	COG0602	queuosine metabolic process
LAD79_RS16520	COG2885	chlorophyll binding
LAD79_RS16525	COG0823	Involved in the tonB-independent uptake of proteins
LAD79_RS16540	COG0811	peptide transport
LAD79_RS16545	COG0824	Thioesterase
LAD79_RS16550	COG2255	four-way junction helicase activity
LAD79_RS16560	COG0632	four-way junction helicase activity
LAD79_RS16565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LAD79_RS16570	COG0217	transcriptional regulatory protein
LAD79_RS16590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LAD79_RS16620	COG0488	(ABC) transporter
LAD79_RS16630	COG4651	solute:proton antiporter activity
LAD79_RS16630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LAD79_RS16640	COG0745	RESPONSE REGULATOR receiver
LAD79_RS16645	COG2205	protein histidine kinase activity
LAD79_RS16655	COG0542	response to heat
LAD79_RS16680	COG0028	Belongs to the TPP enzyme family
LAD79_RS16705	COG3387	PFAM Glycoside hydrolase 15-related
LAD79_RS16710	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LAD79_RS16715	COG3011	Protein conserved in bacteria
LAD79_RS16730	COG0564	pseudouridine synthase activity
LAD79_RS16735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LAD79_RS16745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LAD79_RS16745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LAD79_RS16755	COG0045	succinate-CoA ligase (ADP-forming) activity
LAD79_RS16790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LAD79_RS16810	COG0745	RESPONSE REGULATOR receiver
LAD79_RS16825	COG0189	ligase activity
LAD79_RS16850	COG4625	pathogenesis
LAD79_RS16850	COG3240	lipase activity
LAD79_RS16860	COG2022	thiamine diphosphate biosynthetic process
LAD79_RS16865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LAD79_RS16870	COG0471	metal ion transport
LAD79_RS16870	COG3273	potassium ion transport
LAD79_RS16890	COG1970	mechanosensitive ion channel activity
LAD79_RS16900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LAD79_RS16905	COG1115	amino acid carrier protein
LAD79_RS16915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAD79_RS16920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS16945	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LAD79_RS16955	COG3588	fructose-bisphosphate aldolase
LAD79_RS16960	COG0469	pyruvate kinase activity
LAD79_RS16970	COG0126	phosphoglycerate kinase activity
LAD79_RS16995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LAD79_RS17040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LAD79_RS17045	COG1301	dicarboxylic acid transport
LAD79_RS17075	COG0714	Associated with various cellular activities
LAD79_RS17105	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LAD79_RS17155	COG0254	rRNA binding
LAD79_RS17170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LAD79_RS17180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LAD79_RS17185	COG1758	RNA polymerase activity
LAD79_RS17200	COG0437	4 iron, 4 sulfur cluster binding
LAD79_RS17205	COG2864	formate dehydrogenase
LAD79_RS17215	COG1921	L-seryl-tRNASec selenium transferase activity
LAD79_RS17220	COG3276	selenocysteine insertion sequence binding
LAD79_RS17230	COG0709	Synthesizes selenophosphate from selenide and ATP
LAD79_RS17235	COG1561	YicC-like family, N-terminal region
LAD79_RS17240	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LAD79_RS17245	COG0346	lactoylglutathione lyase activity
LAD79_RS17255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LAD79_RS17270	COG0006	proline dipeptidase activity
LAD79_RS17275	COG0006	proline dipeptidase activity
LAD79_RS17280	COG3079	Belongs to the UPF0149 family
LAD79_RS17300	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LAD79_RS17310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LAD79_RS17320	COG2912	Transglutaminase-like superfamily
LAD79_RS17325	COG1773	rubredoxin
LAD79_RS17330	COG0352	thiamine-phosphate diphosphorylase activity
LAD79_RS17335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LAD79_RS17340	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LAD79_RS17350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LAD79_RS17355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAD79_RS17365	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS17385	COG0671	phosphoesterase, PA-phosphatase related
LAD79_RS17395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LAD79_RS17400	COG0563	adenylate kinase activity
LAD79_RS17420	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LAD79_RS17430	COG0848	biopolymer transport protein
LAD79_RS17440	COG2832	Protein of unknown function (DUF454)
LAD79_RS17475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LAD79_RS17500	COG0745	RESPONSE REGULATOR receiver
LAD79_RS17510	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LAD79_RS17515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LAD79_RS17520	COG0405	Gamma-glutamyltransferase
LAD79_RS17525	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LAD79_RS17545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LAD79_RS17550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LAD79_RS17565	COG0473	3-isopropylmalate dehydrogenase activity
LAD79_RS17580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAD79_RS17585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS17595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LAD79_RS17600	COG1538	Outer membrane efflux protein
LAD79_RS17605	COG0531	amino acid
LAD79_RS17610	COG1519	Transferase
LAD79_RS17615	COG1560	Kdo2-lipid A biosynthetic process
LAD79_RS17655	COG1301	dicarboxylic acid transport
LAD79_RS17665	COG4191	Histidine kinase
LAD79_RS17680	COG0642	Histidine kinase
LAD79_RS17695	COG2851	Citrate transporter
LAD79_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS17720	COG1162	GTPase activity
LAD79_RS17725	COG0436	Aminotransferase
LAD79_RS17745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LAD79_RS17760	COG1228	amidohydrolase
LAD79_RS17765	COG0804	urea catabolic process
LAD79_RS17775	COG1307	EDD domain protein, DegV family
LAD79_RS17815	COG5001	Diguanylate cyclase
LAD79_RS17815	COG2203	Gaf domain
LAD79_RS17815	COG3706	GGDEF domain
LAD79_RS17815	COG4251	negative regulation of phosphorylation
LAD79_RS17820	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LAD79_RS17830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LAD79_RS17845	COG1902	pentaerythritol trinitrate reductase activity
LAD79_RS17870	COG0583	DNA-binding transcription factor activity
LAD79_RS17875	COG1064	alcohol dehydrogenase
LAD79_RS17895	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LAD79_RS17900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LAD79_RS17910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LAD79_RS17915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LAD79_RS17930	COG1522	sequence-specific DNA binding
LAD79_RS17940	COG4773	Receptor
LAD79_RS17965	COG0617	tRNA 3'-terminal CCA addition
LAD79_RS18010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LAD79_RS18015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LAD79_RS18020	COG1609	Transcriptional regulator
LAD79_RS18030	COG0837	glucose binding
LAD79_RS18040	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LAD79_RS18060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LAD79_RS18080	COG4191	Histidine kinase
LAD79_RS18085	COG0784	Response regulator, receiver
LAD79_RS18090	COG4251	negative regulation of phosphorylation
LAD79_RS18095	COG2823	Periplasmic or secreted lipoprotein
LAD79_RS18100	COG0673	inositol 2-dehydrogenase activity
LAD79_RS18115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LAD79_RS18135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LAD79_RS18145	COG2921	Belongs to the UPF0250 family
LAD79_RS18155	COG1686	Belongs to the peptidase S11 family
LAD79_RS18160	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LAD79_RS18165	COG2951	lytic endotransglycosylase activity
LAD79_RS18170	COG0772	Belongs to the SEDS family
LAD79_RS18175	COG0772	Belongs to the SEDS family
LAD79_RS18190	COG1792	Involved in formation and maintenance of cell shape
LAD79_RS18195	COG1077	Cell shape determining protein MreB Mrl
LAD79_RS18200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAD79_RS18215	COG0308	aminopeptidase N
LAD79_RS18220	COG2226	methyltransferase
LAD79_RS18250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAD79_RS18265	COG0673	inositol 2-dehydrogenase activity
LAD79_RS18275	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LAD79_RS18290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LAD79_RS18300	COG2832	Protein of unknown function (DUF454)
LAD79_RS18310	COG0436	Aminotransferase
LAD79_RS18315	COG1505	serine-type exopeptidase activity
LAD79_RS18340	COG0697	spore germination
LAD79_RS18345	COG1666	GTP binding
LAD79_RS18360	COG0339	signal peptide processing
LAD79_RS18370	COG3415	Transposase
LAD79_RS18370	COG2801	Transposase and inactivated derivatives
LAD79_RS18375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LAD79_RS18395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LAD79_RS18405	COG1136	(ABC) transporter
LAD79_RS18410	COG0577	efflux transmembrane transporter activity
LAD79_RS18410	COG1136	(ABC) transporter
LAD79_RS18415	COG0577	efflux transmembrane transporter activity
LAD79_RS18425	COG2204	response regulator
LAD79_RS18430	COG4191	Histidine kinase
LAD79_RS18440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LAD79_RS18450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LAD79_RS18455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LAD79_RS18460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LAD79_RS18465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LAD79_RS18470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LAD79_RS18475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LAD79_RS18485	COG0356	it plays a direct role in the translocation of protons across the membrane
LAD79_RS18500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LAD79_RS18505	COG0508	dehydrogenase complex catalyzes the overall conversion of
LAD79_RS18525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LAD79_RS18550	COG0181	hydroxymethylbilane synthase activity
LAD79_RS18560	COG0745	RESPONSE REGULATOR receiver
LAD79_RS18560	COG2972	Histidine kinase
LAD79_RS18575	COG4771	TonB-dependent receptor
LAD79_RS18590	COG0840	transmembrane signaling receptor activity
LAD79_RS18605	COG0477	Major facilitator Superfamily
LAD79_RS18650	COG4206	TonB-dependent receptor
LAD79_RS18670	COG0625	glutathione transferase activity
LAD79_RS18685	COG2259	Doxx family
LAD79_RS18720	COG4695	Portal protein
LAD79_RS18765	COG3179	chitinase
LAD79_RS18945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LAD79_RS18950	COG1490	D-aminoacyl-tRNA deacylase activity
LAD79_RS18960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LAD79_RS19000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LAD79_RS19000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LAD79_RS19005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LAD79_RS19010	COG0242	peptide deformylase activity
LAD79_RS19020	COG0758	DNA mediated transformation
LAD79_RS19025	COG2922	Belongs to the Smg family
LAD79_RS19040	COG1714	RDD family
LAD79_RS19045	COG1754	DNA topoisomerase type I activity
LAD79_RS19045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LAD79_RS19050	COG0009	L-threonylcarbamoyladenylate synthase
LAD79_RS19065	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS19075	COG0616	signal peptide processing
LAD79_RS19080	COG0534	Mate efflux family protein
LAD79_RS19095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LAD79_RS19100	COG0625	glutathione transferase activity
LAD79_RS19110	COG1252	NADH dehydrogenase
LAD79_RS19130	COG2860	membrane
LAD79_RS19135	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LAD79_RS19155	COG1846	Transcriptional regulator
LAD79_RS19185	COG0459	protein refolding
LAD79_RS19190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LAD79_RS19195	COG2356	endonuclease I
LAD79_RS19200	COG1324	tolerance protein
LAD79_RS19210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LAD79_RS19245	COG4585	Histidine kinase
LAD79_RS19265	COG0583	DNA-binding transcription factor activity
LAD79_RS19280	COG1785	Belongs to the alkaline phosphatase family
LAD79_RS19285	COG1686	Belongs to the peptidase S11 family
LAD79_RS19295	COG2249	NAD(P)H dehydrogenase (quinone) activity
LAD79_RS19315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LAD79_RS19320	COG0511	ligase activity, forming carbon-carbon bonds
LAD79_RS19325	COG0439	Biotin carboxylase
LAD79_RS19340	COG2264	protein methyltransferase activity
LAD79_RS19350	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LAD79_RS19355	COG4589	Belongs to the CDS family
LAD79_RS19360	COG0204	Acyl-transferase
LAD79_RS19370	COG2453	phosphatase
LAD79_RS19370	COG0671	phosphoesterase, PA-phosphatase related
LAD79_RS19375	COG2267	carboxylic ester hydrolase activity
LAD79_RS19380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LAD79_RS19385	COG0138	bifunctional purine biosynthesis protein purh
LAD79_RS19395	COG0151	Belongs to the GarS family
LAD79_RS19410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LAD79_RS19415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LAD79_RS19420	COG2201	protein-glutamate methylesterase activity
LAD79_RS19425	COG2177	Part of the ABC transporter FtsEX involved in
LAD79_RS19430	COG2884	Cell division ATP-binding protein ftsE
LAD79_RS19440	COG3118	belongs to the thioredoxin family
LAD79_RS19445	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LAD79_RS19460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LAD79_RS19470	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LAD79_RS19500	COG3706	GGDEF domain
LAD79_RS19510	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LAD79_RS19545	COG1652	LysM domain
LAD79_RS19550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LAD79_RS19550	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LAD79_RS19565	COG1473	amidohydrolase
LAD79_RS19570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS19575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAD79_RS19580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAD79_RS19585	COG1289	transmembrane transporter activity
LAD79_RS19590	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS19595	COG2814	Major facilitator Superfamily
LAD79_RS19625	COG0316	Belongs to the HesB IscA family
LAD79_RS19665	COG1051	belongs to the nudix hydrolase family
LAD79_RS19680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LAD79_RS19685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LAD79_RS19690	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LAD79_RS19700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LAD79_RS19705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAD79_RS19710	COG0730	response to heat
LAD79_RS19720	COG0134	indole-3-glycerol-phosphate synthase activity
LAD79_RS19725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LAD79_RS19745	COG1597	lipid kinase activity
LAD79_RS19760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LAD79_RS19765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LAD79_RS19775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LAD79_RS19775	COG2111	Na H antiporter
LAD79_RS19780	COG1006	Multisubunit Na H antiporter MnhC subunit
LAD79_RS19785	COG0651	ATP synthesis coupled electron transport
LAD79_RS19790	COG1863	multisubunit Na H antiporter MnhE subunit
LAD79_RS19795	COG2212	antiporter activity
LAD79_RS19800	COG1320	monovalent cation:proton antiporter activity
LAD79_RS19805	COG0530	calcium, potassium:sodium antiporter activity
LAD79_RS19820	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LAD79_RS19850	COG3104	oligopeptide transport
LAD79_RS19855	COG3483	tryptophan 2,3-dioxygenase activity
LAD79_RS19885	COG2378	regulation of single-species biofilm formation
LAD79_RS19900	COG2354	Protein conserved in bacteria
LAD79_RS19905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LAD79_RS19910	COG1368	sulfuric ester hydrolase activity
LAD79_RS19915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LAD79_RS19915	COG3264	Mechanosensitive ion channel
LAD79_RS19920	COG3415	Transposase
LAD79_RS19920	COG2801	Transposase and inactivated derivatives
LAD79_RS19935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LAD79_RS19975	COG1166	arginine decarboxylase activity
LAD79_RS19980	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LAD79_RS20000	COG2960	long-chain fatty acid transporting porin activity
LAD79_RS20055	COG0606	chelatase, subunit chli
LAD79_RS20075	COG0561	phosphatase activity
LAD79_RS20080	COG3932	Exopolysaccharide synthesis, ExoD
LAD79_RS20110	COG1999	signal sequence binding
LAD79_RS20115	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LAD79_RS20120	COG1845	cytochrome c oxidase, subunit III
LAD79_RS20130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LAD79_RS20135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LAD79_RS20150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LAD79_RS20155	COG1104	cysteine desulfurase activity
LAD79_RS20210	COG2031	fatty acid transporter
LAD79_RS20255	COG0673	inositol 2-dehydrogenase activity
LAD79_RS20265	COG1501	Belongs to the glycosyl hydrolase 31 family
LAD79_RS20270	COG2222	sugar isomerase
LAD79_RS20275	COG1940	carbohydrate kinase activity
LAD79_RS20285	COG1349	DNA-binding transcription factor activity
LAD79_RS20290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LAD79_RS20295	COG2814	Major facilitator Superfamily
LAD79_RS20330	COG3210	domain, Protein
LAD79_RS20340	COG3210	domain, Protein
LAD79_RS20360	COG1040	competence protein
LAD79_RS20380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LAD79_RS20385	COG0156	8-amino-7-oxononanoate synthase activity
LAD79_RS20390	COG2267	carboxylic ester hydrolase activity
LAD79_RS20410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LAD79_RS20430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAD79_RS20435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAD79_RS20440	COG2205	protein histidine kinase activity
LAD79_RS20445	COG0745	RESPONSE REGULATOR receiver
LAD79_RS20450	COG3541	Predicted nucleotidyltransferase
LAD79_RS20455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LAD79_RS20480	COG0714	Associated with various cellular activities
LAD79_RS20495	COG0754	glutathionylspermidine amidase activity
LAD79_RS20505	COG0129	dihydroxy-acid dehydratase activity
LAD79_RS20510	COG1199	ATP-dependent helicase activity
LAD79_RS20520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LAD79_RS20540	COG3781	membrane
LAD79_RS20570	COG0625	glutathione transferase activity
LAD79_RS20590	COG2207	Transcriptional regulator
LAD79_RS20605	COG4555	ABC transporter
LAD79_RS20635	COG0543	2 iron, 2 sulfur cluster binding
LAD79_RS20635	COG0633	Ferredoxin
LAD79_RS20640	COG1131	(ABC) transporter
LAD79_RS20645	COG0842	Transport permease protein
LAD79_RS20655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LAD79_RS20665	COG0084	hydrolase, TatD family'
LAD79_RS20670	COG1643	Atp-dependent helicase
LAD79_RS20680	COG1187	pseudouridine synthase activity
LAD79_RS20695	COG0667	Aldo Keto reductase
LAD79_RS20710	COG1690	Belongs to the RtcB family
LAD79_RS20725	COG0840	transmembrane signaling receptor activity
LAD79_RS20730	COG0583	DNA-binding transcription factor activity
LAD79_RS20735	COG2814	Major facilitator Superfamily
LAD79_RS20740	COG0656	L-ascorbic acid biosynthetic process
LAD79_RS20765	COG2267	carboxylic ester hydrolase activity
LAD79_RS20790	COG0045	succinate-CoA ligase (ADP-forming) activity
LAD79_RS20790	COG1042	CoA-binding domain protein
LAD79_RS20790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LAD79_RS20795	COG2239	Acts as a magnesium transporter
LAD79_RS20805	COG0666	response to abiotic stimulus
LAD79_RS20805	COG3177	Filamentation induced by cAMP protein fic
LAD79_RS20810	COG3100	YcgL domain-containing protein
LAD79_RS20820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LAD79_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
LAD79_RS20865	COG2986	histidine ammonia-lyase
LAD79_RS20875	COG0463	Glycosyl transferase, family 2
LAD79_RS20890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LAD79_RS20895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LAD79_RS20910	COG1294	oxidase, subunit
LAD79_RS20915	COG1271	oxidase subunit
LAD79_RS20935	COG1595	DNA-templated transcription, initiation
LAD79_RS20970	COG0408	coproporphyrinogen oxidase activity
LAD79_RS20980	COG2323	membrane
LAD79_RS20995	COG0589	response to stress
LAD79_RS21020	COG0210	DNA helicase
LAD79_RS21030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LAD79_RS21035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LAD79_RS21040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LAD79_RS21045	COG1819	glycosyl
LAD79_RS21060	COG0251	oxidation-reduction process
LAD79_RS21095	COG0463	Glycosyl transferase, family 2
LAD79_RS21110	COG1475	DNA binding
LAD79_RS21115	COG1192	Involved in chromosome partitioning
LAD79_RS21120	COG0357	Ribosomal RNA small subunit methyltransferase G
LAD79_RS21125	COG2091	lysine biosynthetic process via aminoadipic acid
LAD79_RS21165	COG1971	Probably functions as a manganese efflux pump
LAD79_RS21170	COG0784	Response regulator, receiver
LAD79_RS21170	COG2205	protein histidine kinase activity
LAD79_RS21180	COG0443	Heat shock 70 kDa protein
LAD79_RS21195	COG2911	Protein conserved in bacteria
LAD79_RS21200	COG0729	surface antigen
LAD79_RS21210	COG0752	glycyl-tRNA synthetase alpha subunit
LAD79_RS21215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LAD79_RS21220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LAD79_RS21220	COG0519	Catalyzes the synthesis of GMP from XMP
LAD79_RS21230	COG0805	protein transport
LAD79_RS21240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LAD79_RS21250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LAD79_RS21255	COG0596	Alpha beta hydrolase
LAD79_RS21255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LAD79_RS21260	COG0840	transmembrane signaling receptor activity