locus-tag	class	description
G9274_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G9274_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G9274_RS00020	COG0187	DNA topoisomerase II activity
G9274_RS00025	COG1266	CAAX protease self-immunity
G9274_RS00030	COG0501	Belongs to the peptidase M48B family
G9274_RS00165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G9274_RS00175	COG4772	TonB-dependent receptor
G9274_RS00215	COG1012	belongs to the aldehyde dehydrogenase family
G9274_RS00220	COG3284	Transcriptional regulator
G9274_RS00225	COG0800	Aldolase
G9274_RS00250	COG0384	phenazine biosynthesis protein PhzF
G9274_RS00260	COG2755	lipolytic protein G-D-S-L family
G9274_RS00270	COG0657	acetylesterase activity
G9274_RS00270	COG2755	lipolytic protein G-D-S-L family
G9274_RS00280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G9274_RS00305	COG1609	Transcriptional regulator
G9274_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS00320	COG2755	lipolytic protein G-D-S-L family
G9274_RS00325	COG3186	Phenylalanine-4-hydroxylase
G9274_RS00330	COG1522	sequence-specific DNA binding
G9274_RS00335	COG1752	Esterase of the alpha-beta hydrolase superfamily
G9274_RS00345	COG4771	TonB-dependent receptor
G9274_RS00365	COG1122	ATPase activity
G9274_RS00380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G9274_RS00390	COG2815	serine threonine protein kinase
G9274_RS00390	COG0515	serine threonine protein kinase
G9274_RS00395	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G9274_RS00410	COG0210	DNA helicase
G9274_RS00425	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
G9274_RS00430	COG0284	orotidine-5'-phosphate decarboxylase activity
G9274_RS00445	COG2937	Belongs to the GPAT DAPAT family
G9274_RS00455	COG0037	tRNA processing
G9274_RS00460	COG2974	May be involved in recombination
G9274_RS00475	COG2198	Histidine kinase
G9274_RS00475	COG2205	protein histidine kinase activity
G9274_RS00475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G9274_RS00475	COG0784	Response regulator, receiver
G9274_RS00485	COG0493	'glutamate synthase
G9274_RS00490	COG0067	glutamate synthase
G9274_RS00490	COG0069	glutamate synthase activity
G9274_RS00490	COG0070	glutamate synthase
G9274_RS00510	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS00515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G9274_RS00540	COG1111	helicase
G9274_RS00540	COG1205	dead DEAH box helicase
G9274_RS00575	COG0714	Associated with various cellular activities
G9274_RS00620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G9274_RS00640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G9274_RS00665	COG1881	PFAM PEBP family protein
G9274_RS00675	COG1968	undecaprenyl-diphosphatase activity
G9274_RS00680	COG0174	glutamine synthetase
G9274_RS00685	COG0347	Belongs to the P(II) protein family
G9274_RS00690	COG0004	ammonium transporteR
G9274_RS00695	COG3023	N-Acetylmuramoyl-L-alanine amidase
G9274_RS00700	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G9274_RS00725	COG3852	Histidine kinase
G9274_RS00735	COG2032	superoxide dismutase activity
G9274_RS00740	COG2032	superoxide dismutase activity
G9274_RS00750	COG0183	Belongs to the thiolase family
G9274_RS00755	COG3071	HemY protein
G9274_RS00780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G9274_RS00785	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G9274_RS00790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G9274_RS00825	COG0464	growth
G9274_RS00865	COG2197	response regulator
G9274_RS00870	COG2205	protein histidine kinase activity
G9274_RS00870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G9274_RS00890	COG1960	acyl-CoA dehydrogenase activity
G9274_RS00895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G9274_RS00905	COG0612	Peptidase, M16
G9274_RS00915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G9274_RS00920	COG0596	Alpha beta hydrolase
G9274_RS00930	COG0318	PFAM AMP-dependent synthetase and ligase
G9274_RS00935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G9274_RS00945	COG1181	Belongs to the D-alanine--D-alanine ligase family
G9274_RS00955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G9274_RS00980	COG0339	signal peptide processing
G9274_RS01000	COG2814	Major facilitator Superfamily
G9274_RS01005	COG0583	DNA-binding transcription factor activity
G9274_RS01010	COG0583	DNA-binding transcription factor activity
G9274_RS01015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G9274_RS01020	COG2224	Isocitrate lyase
G9274_RS01060	COG3501	Rhs element vgr protein
G9274_RS01065	COG5001	Diguanylate cyclase
G9274_RS01090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G9274_RS01095	COG1960	acyl-CoA dehydrogenase activity
G9274_RS01115	COG0697	spore germination
G9274_RS01125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G9274_RS01140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G9274_RS01145	COG1607	acyl-coa hydrolase
G9274_RS01155	COG1902	pentaerythritol trinitrate reductase activity
G9274_RS01160	COG0583	DNA-binding transcription factor activity
G9274_RS01180	COG1335	isochorismatase
G9274_RS01185	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G9274_RS01215	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G9274_RS01225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G9274_RS01240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G9274_RS01250	COG1752	Esterase of the alpha-beta hydrolase superfamily
G9274_RS01255	COG3800	Transcriptional regulator
G9274_RS01255	COG1396	sequence-specific DNA binding
G9274_RS01265	COG1960	acyl-CoA dehydrogenase activity
G9274_RS01270	COG1024	Enoyl-CoA hydratase
G9274_RS01275	COG1024	Enoyl-CoA hydratase
G9274_RS01285	COG1764	response to oxidative stress
G9274_RS01300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G9274_RS01310	COG0745	RESPONSE REGULATOR receiver
G9274_RS01315	COG2205	protein histidine kinase activity
G9274_RS01320	COG3228	Belongs to the MtfA family
G9274_RS01335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G9274_RS01360	COG3237	CsbD-like
G9274_RS01370	COG0180	Tryptophanyl-tRNA synthetase
G9274_RS01390	COG0477	Major facilitator Superfamily
G9274_RS01395	COG0697	spore germination
G9274_RS01400	COG2962	Rard protein
G9274_RS01405	COG4206	TonB-dependent receptor
G9274_RS01425	COG1136	(ABC) transporter
G9274_RS01435	COG1131	(ABC) transporter
G9274_RS01445	COG4585	Histidine kinase
G9274_RS01450	COG2197	response regulator
G9274_RS01455	COG3038	cytochrome b561
G9274_RS01460	COG0753	catalase activity
G9274_RS01465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G9274_RS01475	COG0628	permease
G9274_RS01510	COG5507	3-demethylubiquinone-9 3-methyltransferase
G9274_RS01515	COG3501	Rhs element vgr protein
G9274_RS01565	COG1309	transcriptional regulator
G9274_RS01580	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS01585	COG2271	Major facilitator Superfamily
G9274_RS01605	COG2186	Transcriptional regulator
G9274_RS01620	COG2814	Major facilitator Superfamily
G9274_RS01625	COG0583	DNA-binding transcription factor activity
G9274_RS01630	COG2131	deaminase
G9274_RS01635	COG4807	Protein conserved in bacteria
G9274_RS01645	COG4221	oxidoreductase activity
G9274_RS01665	COG0018	arginyl-trna synthetase
G9274_RS01675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G9274_RS01680	COG0756	dUTP diphosphatase activity
G9274_RS01695	COG2205	protein histidine kinase activity
G9274_RS01705	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G9274_RS01710	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G9274_RS01725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G9274_RS01730	COG0708	Exodeoxyribonuclease III
G9274_RS01735	COG2223	nitrite transmembrane transporter activity
G9274_RS01750	COG0739	heme binding
G9274_RS01755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G9274_RS01790	COG2234	aminopeptidase activity
G9274_RS01800	COG4942	peptidase
G9274_RS01805	COG0793	Belongs to the peptidase S41A family
G9274_RS01855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G9274_RS01860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G9274_RS01865	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G9274_RS01895	COG0109	protoheme IX farnesyltransferase activity
G9274_RS01915	COG0358	DNA primase activity
G9274_RS01920	COG1295	ribonuclease BN
G9274_RS01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G9274_RS01940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G9274_RS01945	COG0668	transmembrane transport
G9274_RS01960	COG2133	pyrroloquinoline quinone binding
G9274_RS01965	COG4682	membrane
G9274_RS01975	COG0531	amino acid
G9274_RS01985	COG1737	Transcriptional regulator
G9274_RS01990	COG4948	Mandelate Racemase Muconate Lactonizing
G9274_RS02015	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
G9274_RS02040	COG5383	Protein conserved in bacteria
G9274_RS02050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G9274_RS02080	COG0778	Nitroreductase
G9274_RS02085	COG2353	YceI-like domain
G9274_RS02240	COG1943	Transposase
G9274_RS02265	COG0488	(ABC) transporter
G9274_RS02280	COG2814	Major facilitator Superfamily
G9274_RS02290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G9274_RS02295	COG0741	lytic transglycosylase activity
G9274_RS02310	COG3795	YCII-related domain
G9274_RS02315	COG3795	YCII-related domain
G9274_RS02320	COG2764	glyoxalase bleomycin resistance protein dioxygenase
G9274_RS02330	COG4941	Belongs to the sigma-70 factor family
G9274_RS02340	COG3275	phosphorelay sensor kinase activity
G9274_RS02365	COG3590	peptidase
G9274_RS02370	COG5001	Diguanylate cyclase
G9274_RS02385	COG3384	dioxygenase
G9274_RS02390	COG0025	NhaP-type Na H and K H
G9274_RS02415	COG1360	Flagellar Motor Protein
G9274_RS02425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G9274_RS02445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G9274_RS02460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G9274_RS02460	COG2205	protein histidine kinase activity
G9274_RS02480	COG1187	pseudouridine synthase activity
G9274_RS02485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G9274_RS02495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G9274_RS02500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G9274_RS02520	COG0546	phosphoglycolate phosphatase activity
G9274_RS02525	COG4206	TonB-dependent receptor
G9274_RS02540	COG1956	GAF domain-containing protein
G9274_RS02545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G9274_RS02550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G9274_RS02555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G9274_RS02560	COG0785	Cytochrome C biogenesis protein
G9274_RS02560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G9274_RS02565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G9274_RS02570	COG0745	RESPONSE REGULATOR receiver
G9274_RS02575	COG2205	protein histidine kinase activity
G9274_RS02585	COG0720	synthase
G9274_RS02590	COG4206	TonB-dependent receptor
G9274_RS02600	COG0513	Belongs to the DEAD box helicase family
G9274_RS02610	COG0625	glutathione transferase activity
G9274_RS02640	COG0626	cystathionine gamma-synthase activity
G9274_RS02670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G9274_RS02690	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G9274_RS02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G9274_RS02720	COG0463	Glycosyl transferase, family 2
G9274_RS02725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G9274_RS02735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G9274_RS02745	COG2086	electron transfer activity
G9274_RS02795	COG1127	ABC transporter
G9274_RS02800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G9274_RS02815	COG0442	prolyl-tRNA aminoacylation
G9274_RS02825	COG1183	phosphatidylcholine synthase activity
G9274_RS02845	COG0525	valine-tRNA ligase activity
G9274_RS02860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G9274_RS02870	COG0795	lipopolysaccharide-transporting ATPase activity
G9274_RS02880	COG4974	Belongs to the 'phage' integrase family
G9274_RS02885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G9274_RS02895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G9274_RS02895	COG0047	phosphoribosylformylglycinamidine synthase activity
G9274_RS02900	COG5295	Hep Hag repeat protein
G9274_RS02900	COG5295	Hep Hag repeat protein
G9274_RS02905	COG1404	Belongs to the peptidase S8 family
G9274_RS02910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G9274_RS02915	COG1459	type II secretion system
G9274_RS02920	COG2165	general secretion pathway protein
G9274_RS02925	COG4970	Tfp pilus assembly protein FimT
G9274_RS02930	COG2165	general secretion pathway protein
G9274_RS02935	COG4795	General secretion pathway protein
G9274_RS02940	COG3156	type II secretion system protein K
G9274_RS02945	COG3166	PFAM Fimbrial assembly family protein
G9274_RS02960	COG1450	Type ii and iii secretion system protein
G9274_RS02975	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G9274_RS02980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G9274_RS02990	COG1215	transferase activity, transferring glycosyl groups
G9274_RS03010	COG1696	Membrane protein involved in D-alanine export
G9274_RS03020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G9274_RS03030	COG1960	acyl-CoA dehydrogenase activity
G9274_RS03040	COG2252	PERMEase
G9274_RS03045	COG0488	(ABC) transporter
G9274_RS03055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G9274_RS03075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G9274_RS03080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G9274_RS03080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G9274_RS03100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G9274_RS03105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G9274_RS03125	COG3468	outer membrane autotransporter barrel domain protein
G9274_RS03125	COG3266	domain, Protein
G9274_RS03130	COG0277	FAD linked oxidase domain protein
G9274_RS03135	COG1988	membrane-bound metal-dependent
G9274_RS03165	COG2001	Belongs to the MraZ family
G9274_RS03170	COG0275	rRNA processing
G9274_RS03175	COG3116	cell division
G9274_RS03185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G9274_RS03190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G9274_RS03215	COG1181	Belongs to the D-alanine--D-alanine ligase family
G9274_RS03220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G9274_RS03230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G9274_RS03235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G9274_RS03245	COG0739	heme binding
G9274_RS03250	COG0653	protein targeting
G9274_RS03255	COG0494	nUDIX hydrolase
G9274_RS03265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G9274_RS03270	COG1090	epimerase
G9274_RS03275	COG2267	carboxylic ester hydrolase activity
G9274_RS03280	COG3275	phosphorelay sensor kinase activity
G9274_RS03285	COG3279	Response regulator of the LytR AlgR family
G9274_RS03305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G9274_RS03310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G9274_RS03325	COG1607	acyl-coa hydrolase
G9274_RS03330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G9274_RS03355	COG4106	trans-aconitate 2-methyltransferase activity
G9274_RS03360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G9274_RS03375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G9274_RS03380	COG0667	Aldo Keto reductase
G9274_RS03390	COG4771	TonB-dependent receptor
G9274_RS03410	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G9274_RS03415	COG4181	ATPase activity
G9274_RS03430	COG0642	Histidine kinase
G9274_RS03440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G9274_RS03445	COG0861	Integral membrane protein TerC family
G9274_RS03465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G9274_RS03470	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G9274_RS03485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G9274_RS03490	COG2967	ApaG domain
G9274_RS03495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G9274_RS03500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G9274_RS03505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G9274_RS03510	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G9274_RS03520	COG2096	Adenosyltransferase
G9274_RS03530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G9274_RS03535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G9274_RS03545	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
G9274_RS03555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G9274_RS03565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G9274_RS03575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G9274_RS03580	COG0583	DNA-binding transcription factor activity
G9274_RS03585	COG3634	alkyl hydroperoxide reductase activity
G9274_RS03630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G9274_RS03630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G9274_RS03670	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
G9274_RS03680	COG2151	metal-sulfur cluster biosynthetic enzyme
G9274_RS03685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G9274_RS03690	COG1404	Belongs to the peptidase S8 family
G9274_RS03710	COG1295	ribonuclease BN
G9274_RS03715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G9274_RS03730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G9274_RS03735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G9274_RS03750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G9274_RS03760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G9274_RS03770	COG0193	aminoacyl-tRNA hydrolase activity
G9274_RS03775	COG0012	GTP binding
G9274_RS03785	COG4242	Belongs to the peptidase S51 family
G9274_RS03790	COG1446	asparaginase
G9274_RS03810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G9274_RS03820	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G9274_RS03825	COG0250	Participates in transcription elongation, termination and antitermination
G9274_RS03830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G9274_RS03835	COG0081	regulation of translation
G9274_RS03845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G9274_RS03850	COG0222	ribosome binding
G9274_RS03855	COG0085	RNA polymerase activity
G9274_RS03860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G9274_RS03875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G9274_RS03880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G9274_RS03885	COG0051	transcription antitermination factor activity, RNA binding
G9274_RS03890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G9274_RS03895	COG0088	Forms part of the polypeptide exit tunnel
G9274_RS03900	COG0089	rRNA binding
G9274_RS03905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G9274_RS03910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G9274_RS03915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G9274_RS03920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G9274_RS03925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G9274_RS03930	COG0255	Belongs to the universal ribosomal protein uL29 family
G9274_RS03935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G9274_RS03945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G9274_RS03950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G9274_RS03960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G9274_RS03965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G9274_RS03970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G9274_RS03980	COG1841	ribosomal large subunit assembly
G9274_RS03990	COG0201	protein transport
G9274_RS04000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G9274_RS04005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G9274_RS04010	COG0202	RNA polymerase activity
G9274_RS04015	COG0203	ribosomal protein L17
G9274_RS04020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G9274_RS04025	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G9274_RS04035	COG0154	amidase activity
G9274_RS04050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G9274_RS04055	COG0039	L-malate dehydrogenase activity
G9274_RS04060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G9274_RS04075	COG0625	glutathione transferase activity
G9274_RS04085	COG1902	pentaerythritol trinitrate reductase activity
G9274_RS04085	COG0446	pyridine nucleotide-disulphide oxidoreductase
G9274_RS04090	COG2364	Membrane
G9274_RS04110	COG1187	pseudouridine synthase activity
G9274_RS04130	COG1063	alcohol dehydrogenase
G9274_RS04140	COG0406	alpha-ribazole phosphatase activity
G9274_RS04145	COG0285	dihydrofolate synthase activity
G9274_RS04155	COG1286	toxin biosynthetic process
G9274_RS04165	COG2833	Protein of unknown function (DUF455)
G9274_RS04175	COG3291	Pkd domain containing protein
G9274_RS04180	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G9274_RS04185	COG0671	phosphoesterase, PA-phosphatase related
G9274_RS04190	COG0438	transferase activity, transferring glycosyl groups
G9274_RS04195	COG0248	Ppx GppA phosphatase
G9274_RS04200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G9274_RS04215	COG4783	chaperone-mediated protein folding
G9274_RS04230	COG0473	3-isopropylmalate dehydrogenase activity
G9274_RS04280	COG0544	peptidyl-prolyl cis-trans isomerase activity
G9274_RS04285	COG0740	serine-type endopeptidase activity
G9274_RS04290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G9274_RS04325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G9274_RS04330	COG3942	CHAP domain
G9274_RS04330	COG1388	LysM domain
G9274_RS04335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G9274_RS04350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G9274_RS04355	COG0631	protein serine/threonine phosphatase activity
G9274_RS04370	COG0859	PFAM glycosyl transferase family 9
G9274_RS04375	COG3642	lipopolysaccharide core region biosynthetic process
G9274_RS04380	COG1234	tRNA 3'-trailer cleavage
G9274_RS04435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G9274_RS04445	COG0537	adenosine 5'-monophosphoramidase activity
G9274_RS04465	COG0714	Associated with various cellular activities
G9274_RS04480	COG1399	metal-binding, possibly nucleic acid-binding protein
G9274_RS04485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G9274_RS04490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G9274_RS04500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G9274_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS04515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G9274_RS04520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G9274_RS04525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G9274_RS04530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G9274_RS04630	COG0393	Putative heavy-metal-binding
G9274_RS04665	COG0583	DNA-binding transcription factor activity
G9274_RS04700	COG0583	DNA-binding transcription factor activity
G9274_RS04710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G9274_RS04740	COG2818	Glycosylase
G9274_RS04745	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
G9274_RS04750	COG1678	Uncharacterized ACR, COG1678
G9274_RS04755	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G9274_RS04760	COG0540	Belongs to the ATCase OTCase family
G9274_RS04780	COG2239	Acts as a magnesium transporter
G9274_RS04785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G9274_RS04800	COG1660	Displays ATPase and GTPase activities
G9274_RS04805	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G9274_RS04810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G9274_RS04825	COG1137	ATPase activity
G9274_RS04855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G9274_RS04875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G9274_RS04890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G9274_RS04900	COG0628	permease
G9274_RS04910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G9274_RS04915	COG3178	'Phosphotransferase
G9274_RS04930	COG1555	photosystem II stabilization
G9274_RS04950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G9274_RS04975	COG4771	TonB-dependent receptor
G9274_RS04995	COG4774	siderophore transport
G9274_RS05005	COG2146	nitrite reductase [NAD(P)H] activity
G9274_RS05080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G9274_RS05085	COG0719	Fe-S assembly protein
G9274_RS05090	COG0396	ATPase activity
G9274_RS05100	COG0719	Fe-S assembly protein
G9274_RS05140	COG1764	response to oxidative stress
G9274_RS05150	COG0384	phenazine biosynthesis protein PhzF
G9274_RS05155	COG0527	aspartate kinase activity
G9274_RS05165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G9274_RS05175	COG0142	geranyltranstransferase activity
G9274_RS05180	COG0366	Alpha amylase catalytic
G9274_RS05190	COG1082	Xylose isomerase domain protein TIM barrel
G9274_RS05200	COG2190	(PTS) system
G9274_RS05200	COG2211	Major facilitator Superfamily
G9274_RS05220	COG1131	(ABC) transporter
G9274_RS05230	COG0629	single-stranded DNA binding
G9274_RS05265	COG1408	metallophosphoesterase
G9274_RS05280	COG0640	Transcriptional regulator
G9274_RS05300	COG0477	Major facilitator Superfamily
G9274_RS05310	COG0579	oxidoreductase
G9274_RS05355	COG3104	oligopeptide transport
G9274_RS05365	COG1297	OPT oligopeptide transporter protein
G9274_RS05370	COG1506	peptidase
G9274_RS05370	COG0823	Involved in the tonB-independent uptake of proteins
G9274_RS05385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G9274_RS05390	COG2894	cell division
G9274_RS05405	COG4585	Histidine kinase
G9274_RS05410	COG2197	response regulator
G9274_RS05425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G9274_RS05445	COG1073	alpha beta
G9274_RS05465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G9274_RS05475	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G9274_RS05485	COG1595	DNA-templated transcription, initiation
G9274_RS05495	COG1946	Acyl-CoA thioesterase
G9274_RS05500	COG1024	Enoyl-CoA hydratase
G9274_RS05510	COG0824	Thioesterase
G9274_RS05515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G9274_RS05525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G9274_RS05530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G9274_RS05540	COG0728	peptidoglycan biosynthetic process
G9274_RS05545	COG0196	riboflavin kinase activity
G9274_RS05550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G9274_RS05560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G9274_RS05575	COG3422	double-strand break repair
G9274_RS05580	COG4206	TonB-dependent receptor
G9274_RS05605	COG3209	COG3209 Rhs family protein
G9274_RS05645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G9274_RS05650	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G9274_RS05650	COG2755	lipolytic protein G-D-S-L family
G9274_RS05660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G9274_RS05665	COG1845	cytochrome c oxidase, subunit III
G9274_RS05670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G9274_RS05685	COG0326	Molecular chaperone. Has ATPase activity
G9274_RS05705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G9274_RS05715	COG2070	2-Nitropropane dioxygenase
G9274_RS05730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G9274_RS05735	COG0336	Belongs to the RNA methyltransferase TrmD family
G9274_RS05745	COG0534	Mate efflux family protein
G9274_RS05760	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G9274_RS05770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G9274_RS05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G9274_RS05805	COG4716	Myosin-crossreactive antigen
G9274_RS05825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G9274_RS05840	COG0739	heme binding
G9274_RS05875	COG3706	GGDEF domain
G9274_RS05885	COG0588	phosphoglycerate mutase activity
G9274_RS05890	COG3590	peptidase
G9274_RS05905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G9274_RS05915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G9274_RS05920	COG0745	RESPONSE REGULATOR receiver
G9274_RS05925	COG2205	protein histidine kinase activity
G9274_RS05930	COG4452	Inner membrane protein CreD
G9274_RS05950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G9274_RS05955	COG0735	belongs to the Fur family
G9274_RS06035	COG5001	Diguanylate cyclase
G9274_RS06035	COG5002	protein histidine kinase activity
G9274_RS06045	COG1187	pseudouridine synthase activity
G9274_RS06050	COG3706	GGDEF domain
G9274_RS06055	COG5342	invasion associated locus B
G9274_RS06060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G9274_RS06085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G9274_RS06090	COG1132	(ABC) transporter
G9274_RS06110	COG0583	DNA-binding transcription factor activity
G9274_RS06125	COG1695	Transcriptional regulator
G9274_RS06150	COG0825	malonyl-CoA metabolic process
G9274_RS06170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G9274_RS06175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G9274_RS06185	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G9274_RS06200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G9274_RS06205	COG0575	Belongs to the CDS family
G9274_RS06210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G9274_RS06220	COG0528	UMP kinase activity
G9274_RS06225	COG3706	GGDEF domain
G9274_RS06240	COG0052	Belongs to the universal ribosomal protein uS2 family
G9274_RS06260	COG3188	usher protein
G9274_RS06275	COG0024	Methionine aminopeptidase
G9274_RS06280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G9274_RS06295	COG1393	Belongs to the ArsC family
G9274_RS06300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G9274_RS06315	COG0367	asparagine synthase
G9274_RS06320	COG0475	glutathione-regulated potassium exporter activity
G9274_RS06355	COG1566	PFAM secretion protein HlyD family protein
G9274_RS06360	COG2814	Major facilitator Superfamily
G9274_RS06385	COG0557	exoribonuclease II activity
G9274_RS06395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G9274_RS06405	COG1136	(ABC) transporter
G9274_RS06405	COG0577	efflux transmembrane transporter activity
G9274_RS06410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G9274_RS06425	COG3706	GGDEF domain
G9274_RS06430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G9274_RS06435	COG2259	Doxx family
G9274_RS06445	COG3220	belongs to the UPF0276 family
G9274_RS06455	COG0704	Plays a role in the regulation of phosphate uptake
G9274_RS06465	COG0581	inorganic phosphate transmembrane transporter activity
G9274_RS06470	COG0573	inorganic phosphate transmembrane transporter activity
G9274_RS06475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G9274_RS06480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G9274_RS06495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G9274_RS06505	COG1024	Enoyl-CoA hydratase
G9274_RS06535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G9274_RS06535	COG0116	Belongs to the methyltransferase superfamily
G9274_RS06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G9274_RS06560	COG1104	cysteine desulfurase activity
G9274_RS06570	COG2733	membrane
G9274_RS06585	COG1012	belongs to the aldehyde dehydrogenase family
G9274_RS06590	COG0477	Major facilitator Superfamily
G9274_RS06595	COG2703	oxygen carrier activity
G9274_RS06615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G9274_RS06620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G9274_RS06625	COG0174	glutamine synthetase
G9274_RS06635	COG3842	ATPase activity
G9274_RS06640	COG1176	ABC-type spermidine putrescine transport system, permease component I
G9274_RS06645	COG1177	transmembrane transport
G9274_RS06650	COG1012	belongs to the aldehyde dehydrogenase family
G9274_RS06665	COG4535	Mg2 and Co2 transporter CorC
G9274_RS06680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G9274_RS06690	COG1702	phosphate starvation-inducible protein PhoH
G9274_RS06695	COG3501	Rhs element vgr protein
G9274_RS06700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G9274_RS06735	COG1129	ABC transporter
G9274_RS06735	COG0842	Transport permease protein
G9274_RS06740	COG0842	Transport permease protein
G9274_RS06745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G9274_RS06750	COG0741	lytic transglycosylase activity
G9274_RS06755	COG0723	plastoquinol--plastocyanin reductase activity
G9274_RS06760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G9274_RS06765	COG2857	Cytochrome c1
G9274_RS06770	COG0625	glutathione transferase activity
G9274_RS06775	COG2969	positive regulation of protein catabolic process
G9274_RS06815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G9274_RS06820	COG0300	oxidoreductase activity
G9274_RS06830	COG1611	Belongs to the LOG family
G9274_RS06835	COG4969	Belongs to the N-Me-Phe pilin family
G9274_RS06875	COG0556	nucleotide-excision repair
G9274_RS06885	COG2333	competence protein COMEC
G9274_RS06885	COG0658	competence protein
G9274_RS06890	COG0811	peptide transport
G9274_RS06895	COG0848	biopolymer transport protein
G9274_RS06905	COG1663	tetraacyldisaccharide 4'-kinase activity
G9274_RS06910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G9274_RS06915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G9274_RS06925	COG0322	excinuclease ABC activity
G9274_RS06930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G9274_RS07080	COG4695	Portal protein
G9274_RS07085	COG0740	serine-type endopeptidase activity
G9274_RS07170	COG0348	domain, Protein
G9274_RS07185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G9274_RS07205	COG2200	EAL domain
G9274_RS07210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G9274_RS07215	COG0069	glutamate synthase activity
G9274_RS07220	COG0456	acetyltransferase
G9274_RS07245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G9274_RS07260	COG1253	flavin adenine dinucleotide binding
G9274_RS07270	COG0306	phosphate transporter
G9274_RS07275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G9274_RS07290	COG0504	CTP synthase activity
G9274_RS07300	COG0148	phosphopyruvate hydratase activity
G9274_RS07305	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G9274_RS07310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G9274_RS07315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G9274_RS07325	COG2840	Smr protein MutS2
G9274_RS07330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G9274_RS07335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G9274_RS07340	COG1238	metal cluster binding
G9274_RS07355	COG1534	Rna-binding protein
G9274_RS07360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G9274_RS07365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G9274_RS07375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G9274_RS07380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G9274_RS07385	COG1923	regulation of RNA biosynthetic process
G9274_RS07390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G9274_RS07395	COG1546	Belongs to the CinA family
G9274_RS07400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G9274_RS07405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G9274_RS07410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G9274_RS07415	COG2137	regulation of response to DNA damage stimulus
G9274_RS07420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G9274_RS07425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G9274_RS07445	COG1741	Belongs to the pirin family
G9274_RS07450	COG0583	DNA-binding transcription factor activity
G9274_RS07480	COG0351	phosphomethylpyrimidine kinase
G9274_RS07480	COG0352	thiamine-phosphate diphosphorylase activity
G9274_RS07495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G9274_RS07500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G9274_RS07510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G9274_RS07520	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G9274_RS07530	COG0477	Major facilitator Superfamily
G9274_RS07540	COG0617	tRNA 3'-terminal CCA addition
G9274_RS07550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G9274_RS07555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G9274_RS07560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G9274_RS07565	COG0166	Belongs to the GPI family
G9274_RS07570	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G9274_RS07580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G9274_RS07585	COG0671	phosphoesterase, PA-phosphatase related
G9274_RS07595	COG0800	Aldolase
G9274_RS07610	COG0837	glucose binding
G9274_RS07615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G9274_RS07620	COG3842	ATPase activity
G9274_RS07635	COG2009	succinate dehydrogenase
G9274_RS07640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G9274_RS07650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G9274_RS07665	COG4591	ABC-type transport system involved in lipoprotein release permease component
G9274_RS07680	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G9274_RS07690	COG0552	protein localization to endoplasmic reticulum
G9274_RS07700	COG0326	Molecular chaperone. Has ATPase activity
G9274_RS07705	COG0742	ribosomal rna small subunit methyltransferase
G9274_RS07710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G9274_RS07720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G9274_RS07725	COG0405	Gamma-glutamyltransferase
G9274_RS07730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G9274_RS07740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G9274_RS07760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G9274_RS07775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G9274_RS07795	COG1191	sigma factor activity
G9274_RS07805	COG0415	Belongs to the DNA photolyase family
G9274_RS07810	COG2885	chlorophyll binding
G9274_RS07815	COG0583	DNA-binding transcription factor activity
G9274_RS07890	COG0583	DNA-binding transcription factor activity
G9274_RS07895	COG1335	isochorismatase
G9274_RS07910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G9274_RS07925	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G9274_RS07930	COG0735	belongs to the Fur family
G9274_RS07935	COG0497	DNA recombination
G9274_RS07940	COG1420	regulation of RNA biosynthetic process
G9274_RS07945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G9274_RS07950	COG0443	Heat shock 70 kDa protein
G9274_RS07955	COG0484	heat shock protein binding
G9274_RS07965	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G9274_RS07980	COG1132	(ABC) transporter
G9274_RS08000	COG5001	Diguanylate cyclase
G9274_RS08010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G9274_RS08015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G9274_RS08025	COG1862	Preprotein translocase
G9274_RS08030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G9274_RS08035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G9274_RS08040	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G9274_RS08050	COG2081	HI0933 family
G9274_RS08055	COG4681	YaeQ
G9274_RS08060	COG0564	pseudouridine synthase activity
G9274_RS08075	COG0625	glutathione transferase activity
G9274_RS08080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G9274_RS08090	COG0513	Belongs to the DEAD box helicase family
G9274_RS08100	COG0583	DNA-binding transcription factor activity
G9274_RS08130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G9274_RS08145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G9274_RS08150	COG2957	Belongs to the agmatine deiminase family
G9274_RS08160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G9274_RS08165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G9274_RS08175	COG0776	regulation of translation
G9274_RS08185	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G9274_RS08190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G9274_RS08200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G9274_RS08205	COG0183	Belongs to the thiolase family
G9274_RS08210	COG1250	3-hydroxyacyl-CoA dehydrogenase
G9274_RS08210	COG1024	Enoyl-CoA hydratase
G9274_RS08220	COG0105	UTP biosynthetic process
G9274_RS08235	COG1426	Protein conserved in bacteria
G9274_RS08245	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G9274_RS08250	COG1160	GTP binding
G9274_RS08255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G9274_RS08260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G9274_RS08260	COG0475	glutathione-regulated potassium exporter activity
G9274_RS08265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G9274_RS08275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G9274_RS08275	COG0519	Catalyzes the synthesis of GMP from XMP
G9274_RS08310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G9274_RS08315	COG0167	dihydroorotate dehydrogenase activity
G9274_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS08330	COG1012	belongs to the aldehyde dehydrogenase family
G9274_RS08335	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G9274_RS08400	COG0527	aspartate kinase activity
G9274_RS08400	COG0460	homoserine dehydrogenase
G9274_RS08415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G9274_RS08420	COG0124	histidyl-tRNA synthetase
G9274_RS08445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G9274_RS08455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G9274_RS08460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G9274_RS08465	COG0107	imidazoleglycerol-phosphate synthase activity
G9274_RS08470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G9274_RS08470	COG0140	phosphoribosyl-ATP diphosphatase activity
G9274_RS08480	COG0837	glucose binding
G9274_RS08485	COG1446	asparaginase
G9274_RS08490	COG3142	Participates in the control of copper homeostasis
G9274_RS08500	COG3537	Alpha-1,2-mannosidase
G9274_RS08505	COG1609	Transcriptional regulator
G9274_RS08515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G9274_RS08535	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
G9274_RS08540	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
G9274_RS08545	COG0235	Class ii aldolase
G9274_RS08550	COG0531	amino acid
G9274_RS08555	COG0531	amino acid
G9274_RS08565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G9274_RS08570	COG0277	FAD linked oxidase domain protein
G9274_RS08590	COG0745	RESPONSE REGULATOR receiver
G9274_RS08595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G9274_RS08600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G9274_RS08620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G9274_RS08655	COG1918	ferrous iron import across plasma membrane
G9274_RS08655	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G9274_RS08665	COG2249	NAD(P)H dehydrogenase (quinone) activity
G9274_RS08670	COG0789	Transcriptional regulator
G9274_RS08675	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS08680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G9274_RS08685	COG0505	Belongs to the CarA family
G9274_RS08695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G9274_RS08700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G9274_RS08710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G9274_RS08720	COG4676	Protein conserved in bacteria
G9274_RS08725	COG0671	phosphoesterase, PA-phosphatase related
G9274_RS08730	COG3279	Response regulator of the LytR AlgR family
G9274_RS08735	COG0501	Belongs to the peptidase M48B family
G9274_RS08745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G9274_RS08755	COG2205	protein histidine kinase activity
G9274_RS08755	COG2198	Histidine kinase
G9274_RS08755	COG0784	Response regulator, receiver
G9274_RS08765	COG1024	Enoyl-CoA hydratase
G9274_RS08770	COG0318	PFAM AMP-dependent synthetase and ligase
G9274_RS08810	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G9274_RS08815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G9274_RS08820	COG0840	transmembrane signaling receptor activity
G9274_RS08825	COG0840	transmembrane signaling receptor activity
G9274_RS08835	COG0835	chemotaxis
G9274_RS08840	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G9274_RS08845	COG0840	transmembrane signaling receptor activity
G9274_RS08855	COG0745	RESPONSE REGULATOR receiver
G9274_RS08875	COG1360	Flagellar Motor Protein
G9274_RS08880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G9274_RS08885	COG2198	Histidine kinase
G9274_RS08885	COG0643	Histidine kinase
G9274_RS08885	COG0784	Response regulator, receiver
G9274_RS08890	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G9274_RS08915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G9274_RS08920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G9274_RS08955	COG1987	bacterial-type flagellum assembly
G9274_RS08965	COG3190	flagellar
G9274_RS09015	COG1677	Flagellar hook-basal body complex protein FliE
G9274_RS09055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G9274_RS09055	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G9274_RS09100	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G9274_RS09110	COG4787	bacterial-type flagellum-dependent cell motility
G9274_RS09125	COG1558	bacterial-type flagellum-dependent cell motility
G9274_RS09135	COG0835	chemotaxis
G9274_RS09135	COG0784	Response regulator, receiver
G9274_RS09165	COG3851	Histidine kinase
G9274_RS09185	COG2915	High frequency lysogenization protein hflD homolog
G9274_RS09190	COG0482	sulfurtransferase activity
G9274_RS09205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G9274_RS09215	COG0542	response to heat
G9274_RS09240	COG0492	ferredoxin-NADP+ reductase activity
G9274_RS09245	COG1674	ftsk spoiiie
G9274_RS09260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G9274_RS09265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G9274_RS09270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G9274_RS09290	COG0583	DNA-binding transcription factor activity
G9274_RS09300	COG0625	glutathione transferase activity
G9274_RS09305	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G9274_RS09335	COG2819	hydrolase of the alpha beta superfamily
G9274_RS09345	COG4558	Periplasmic binding protein
G9274_RS09350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G9274_RS09355	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G9274_RS09360	COG4774	siderophore transport
G9274_RS09365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G9274_RS09375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G9274_RS09405	COG1070	Carbohydrate kinase
G9274_RS09415	COG0477	Major facilitator Superfamily
G9274_RS09420	COG1472	Belongs to the glycosyl hydrolase 3 family
G9274_RS09430	COG3661	Belongs to the glycosyl hydrolase 67 family
G9274_RS09440	COG3507	Belongs to the glycosyl hydrolase 43 family
G9274_RS09445	COG1472	Belongs to the glycosyl hydrolase 3 family
G9274_RS09520	COG4644	lycopene metabolic process
G9274_RS09540	COG2194	sulfuric ester hydrolase activity
G9274_RS09545	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G9274_RS09575	COG0745	RESPONSE REGULATOR receiver
G9274_RS09595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G9274_RS09615	COG2132	Multicopper oxidase
G9274_RS09675	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G9274_RS09680	COG0789	Transcriptional regulator
G9274_RS09705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G9274_RS09710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G9274_RS09725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G9274_RS09730	COG2217	Heavy metal translocating P-type atpase
G9274_RS09735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G9274_RS09810	COG0300	oxidoreductase activity
G9274_RS09825	COG0642	Histidine kinase
G9274_RS09890	COG2610	gluconate transmembrane transporter activity
G9274_RS09910	COG0642	Histidine kinase
G9274_RS09925	COG0318	PFAM AMP-dependent synthetase and ligase
G9274_RS09930	COG1012	belongs to the aldehyde dehydrogenase family
G9274_RS09945	COG3300	MHYT domain
G9274_RS09945	COG5001	Diguanylate cyclase
G9274_RS09960	COG4771	TonB-dependent receptor
G9274_RS10005	COG1309	transcriptional regulator
G9274_RS10030	COG3537	Alpha-1,2-mannosidase
G9274_RS10045	COG3118	belongs to the thioredoxin family
G9274_RS10120	COG0840	transmembrane signaling receptor activity
G9274_RS10125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G9274_RS10130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G9274_RS10145	COG2885	chlorophyll binding
G9274_RS10160	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS10165	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G9274_RS10165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G9274_RS10175	COG3433	isochorismatase activity
G9274_RS10175	COG1535	isochorismatase
G9274_RS10180	COG1021	2,3-dihydroxybenzoate-AMP ligase
G9274_RS10185	COG1169	isochorismate synthase
G9274_RS10195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G9274_RS10200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G9274_RS10205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G9274_RS10210	COG0716	FMN binding
G9274_RS10220	COG2409	Drug exporters of the RND superfamily
G9274_RS10225	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS10230	COG0583	DNA-binding transcription factor activity
G9274_RS10270	COG1914	H( )-stimulated, divalent metal cation uptake system
G9274_RS10275	COG0789	Transcriptional regulator
G9274_RS10285	COG0477	Major facilitator Superfamily
G9274_RS10290	COG1999	signal sequence binding
G9274_RS10300	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G9274_RS10305	COG1845	cytochrome c oxidase, subunit III
G9274_RS10310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G9274_RS10315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G9274_RS10320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G9274_RS10345	COG0789	Transcriptional regulator
G9274_RS10365	COG2885	chlorophyll binding
G9274_RS10365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G9274_RS10435	COG1335	isochorismatase
G9274_RS10495	COG3501	Rhs element vgr protein
G9274_RS10550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G9274_RS10560	COG3501	Rhs element vgr protein
G9274_RS10625	COG3501	Rhs element vgr protein
G9274_RS10630	COG3179	chitinase
G9274_RS10660	COG0277	FAD linked oxidase domain protein
G9274_RS10670	COG2186	Transcriptional regulator
G9274_RS10695	COG1285	pathogenesis
G9274_RS10705	COG1902	pentaerythritol trinitrate reductase activity
G9274_RS10730	COG0583	DNA-binding transcription factor activity
G9274_RS10735	COG1472	Belongs to the glycosyl hydrolase 3 family
G9274_RS10745	COG2814	Major facilitator Superfamily
G9274_RS10775	COG0587	DNA-directed DNA polymerase activity
G9274_RS10795	COG0505	Belongs to the CarA family
G9274_RS10815	COG0024	Methionine aminopeptidase
G9274_RS10835	COG1982	Orn Lys Arg decarboxylase major
G9274_RS10840	COG0531	amino acid
G9274_RS10845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G9274_RS10855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G9274_RS10940	COG2755	lipolytic protein G-D-S-L family
G9274_RS10940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G9274_RS10975	COG3179	chitinase
G9274_RS11000	COG3447	MASE1 domain protein
G9274_RS11000	COG5002	protein histidine kinase activity
G9274_RS11000	COG5001	Diguanylate cyclase
G9274_RS11005	COG2183	response to ionizing radiation
G9274_RS11030	COG3243	poly(R)-hydroxyalkanoic acid synthase
G9274_RS11060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G9274_RS11075	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G9274_RS11080	COG0590	tRNA wobble adenosine to inosine editing
G9274_RS11100	COG2814	Major facilitator Superfamily
G9274_RS11125	COG3161	chorismate lyase activity
G9274_RS11145	COG0363	glucosamine-6-phosphate deaminase activity
G9274_RS11155	COG0210	DNA helicase
G9274_RS11180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G9274_RS11190	COG0583	DNA-binding transcription factor activity
G9274_RS11250	COG1074	ATP-dependent DNA helicase activity
G9274_RS11325	COG3685	Protein conserved in bacteria
G9274_RS11360	COG1063	alcohol dehydrogenase
G9274_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS11385	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS11390	COG3387	PFAM Glycoside hydrolase 15-related
G9274_RS11450	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
G9274_RS11455	COG0631	protein serine/threonine phosphatase activity
G9274_RS11460	COG4245	von Willebrand factor, type A
G9274_RS11485	COG0583	DNA-binding transcription factor activity
G9274_RS11490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G9274_RS11500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G9274_RS11520	COG1605	Chorismate mutase
G9274_RS11520	COG0077	Prephenate dehydratase
G9274_RS11525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G9274_RS11560	COG1228	amidohydrolase
G9274_RS11575	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G9274_RS11620	COG4993	Dehydrogenase
G9274_RS11630	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G9274_RS11640	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G9274_RS11650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G9274_RS11670	COG0359	binds to the 23S rRNA
G9274_RS11675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G9274_RS11680	COG0360	Binds together with S18 to 16S ribosomal RNA
G9274_RS11690	COG0793	Belongs to the peptidase S41A family
G9274_RS11695	COG0577	efflux transmembrane transporter activity
G9274_RS11700	COG1136	(ABC) transporter
G9274_RS11700	COG0577	efflux transmembrane transporter activity
G9274_RS11780	COG0316	Belongs to the HesB IscA family
G9274_RS11785	COG0017	Asparaginyl-tRNA synthetase
G9274_RS11805	COG0288	reversible hydration of carbon dioxide
G9274_RS11815	COG3844	kynureninase activity
G9274_RS11820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G9274_RS11825	COG2925	Exonuclease
G9274_RS11835	COG0667	Aldo Keto reductase
G9274_RS11855	COG2902	Dehydrogenase
G9274_RS11870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G9274_RS11875	COG1960	acyl-CoA dehydrogenase activity
G9274_RS11880	COG2226	methyltransferase
G9274_RS11890	COG1410	methionine synthase
G9274_RS11890	COG0646	methionine synthase
G9274_RS11905	COG2900	Belongs to the SlyX family
G9274_RS11920	COG0386	Belongs to the glutathione peroxidase family
G9274_RS11930	COG1725	Transcriptional regulator
G9274_RS11935	COG1131	(ABC) transporter
G9274_RS11965	COG1253	flavin adenine dinucleotide binding
G9274_RS11975	COG2850	peptidyl-arginine hydroxylation
G9274_RS11985	COG0567	Dehydrogenase, E1 component
G9274_RS11990	COG0508	dehydrogenase complex catalyzes the overall conversion of
G9274_RS12010	COG0305	Participates in initiation and elongation during chromosome replication
G9274_RS12025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G9274_RS12035	COG0519	Catalyzes the synthesis of GMP from XMP
G9274_RS12050	COG0084	hydrolase, TatD family'
G9274_RS12055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G9274_RS12075	COG2839	Protein conserved in bacteria
G9274_RS12100	COG0625	glutathione transferase activity
G9274_RS12105	COG1280	lysine exporter protein (LysE YggA)
G9274_RS12125	COG1595	DNA-templated transcription, initiation
G9274_RS12130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G9274_RS12145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G9274_RS12150	COG0386	Belongs to the glutathione peroxidase family
G9274_RS12155	COG0339	signal peptide processing
G9274_RS12160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G9274_RS12185	COG3104	oligopeptide transport
G9274_RS12195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G9274_RS12215	COG0316	Belongs to the HesB IscA family
G9274_RS12215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G9274_RS12220	COG2154	pterin-4-alpha-carbinolamine dehydratase
G9274_RS12230	COG0428	transporter
G9274_RS12235	COG0564	pseudouridine synthase activity
G9274_RS12240	COG1530	ribonuclease E activity
G9274_RS12260	COG0395	ABC-type sugar transport system, permease component
G9274_RS12285	COG1609	Transcriptional regulator
G9274_RS12295	COG2350	Protein conserved in bacteria
G9274_RS12300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G9274_RS12305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G9274_RS12310	COG1187	pseudouridine synthase activity
G9274_RS12325	COG0436	Aminotransferase
G9274_RS12350	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G9274_RS12355	COG1138	Cytochrome C-type biogenesis protein
G9274_RS12360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G9274_RS12375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G9274_RS12395	COG3459	Glycosyltransferase 36 associated
G9274_RS12490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G9274_RS12495	COG4988	ABC transporter
G9274_RS12505	COG1294	oxidase, subunit
G9274_RS12545	COG0165	Argininosuccinate lyase
G9274_RS12550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G9274_RS12560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G9274_RS12565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G9274_RS12570	COG0137	argininosuccinate synthase activity
G9274_RS12575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G9274_RS12590	COG2166	iron-sulfur cluster assembly
G9274_RS12610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G9274_RS12630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G9274_RS12635	COG0402	S-adenosylhomocysteine deaminase activity
G9274_RS12645	COG1509	lysine 2,3-aminomutase activity
G9274_RS12650	COG5001	Diguanylate cyclase
G9274_RS12650	COG3300	MHYT domain
G9274_RS12665	COG0483	inositol monophosphate 1-phosphatase activity
G9274_RS12670	COG0501	Belongs to the peptidase M48B family
G9274_RS12680	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS12700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G9274_RS12705	COG0860	N-Acetylmuramoyl-L-alanine amidase
G9274_RS12710	COG0802	atpase or kinase
G9274_RS12715	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G9274_RS12715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G9274_RS12720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G9274_RS12735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G9274_RS12745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G9274_RS12750	COG4771	TonB-dependent receptor
G9274_RS12780	COG0477	Major facilitator Superfamily
G9274_RS12820	COG2135	peptidase activity
G9274_RS12940	COG0582	viral genome integration into host DNA
G9274_RS12945	COG5487	UPF0391 membrane protein
G9274_RS12950	COG3040	lipid binding
G9274_RS12960	COG1960	acyl-CoA dehydrogenase activity
G9274_RS12970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G9274_RS13010	COG0745	RESPONSE REGULATOR receiver
G9274_RS13015	COG3713	MltA-interacting MipA family protein
G9274_RS13115	COG0776	regulation of translation
G9274_RS13125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G9274_RS13140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G9274_RS13145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G9274_RS13180	COG1185	polyribonucleotide nucleotidyltransferase activity
G9274_RS13185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G9274_RS13190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G9274_RS13195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G9274_RS13200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G9274_RS13205	COG0195	Participates in both transcription termination and antitermination
G9274_RS13210	COG0779	Required for maturation of 30S ribosomal subunits
G9274_RS13225	COG1007	ATP synthesis coupled electron transport
G9274_RS13255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G9274_RS13260	COG1034	ATP synthesis coupled electron transport
G9274_RS13265	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G9274_RS13270	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G9274_RS13275	COG0649	NAD binding
G9274_RS13280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G9274_RS13285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G9274_RS13290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G9274_RS13305	COG0149	triose-phosphate isomerase activity
G9274_RS13320	COG0726	polysaccharide deacetylase
G9274_RS13325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G9274_RS13330	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G9274_RS13335	COG0159	tryptophan synthase activity
G9274_RS13345	COG0133	tryptophan synthase activity
G9274_RS13355	COG0135	phosphoribosylanthranilate isomerase activity
G9274_RS13360	COG0101	tRNA pseudouridine synthase activity
G9274_RS13370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G9274_RS13390	COG2890	protein-(glutamine-N5) methyltransferase activity
G9274_RS13395	COG1999	signal sequence binding
G9274_RS13400	COG0688	phosphatidylethanolamine metabolic process
G9274_RS13415	COG0433	COG0433 Predicted ATPase
G9274_RS13420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G9274_RS13430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G9274_RS13435	COG0412	Dienelactone hydrolase
G9274_RS13450	COG0717	Belongs to the dCTP deaminase family
G9274_RS13455	COG0489	protein tyrosine kinase activity
G9274_RS13460	COG4771	TonB-dependent receptor
G9274_RS13465	COG4771	TonB-dependent receptor
G9274_RS13470	COG4771	TonB-dependent receptor
G9274_RS13480	COG3590	peptidase
G9274_RS13510	COG2311	Membrane
G9274_RS13520	COG0791	NLP P60 protein
G9274_RS13525	COG0791	NLP P60 protein
G9274_RS13565	COG1301	dicarboxylic acid transport
G9274_RS13585	COG1722	exodeoxyribonuclease VII activity
G9274_RS13590	COG0142	geranyltranstransferase activity
G9274_RS13600	COG0312	modulator of DNA gyrase
G9274_RS13605	COG3028	Belongs to the UPF0307 family
G9274_RS13610	COG0312	modulator of DNA gyrase
G9274_RS13620	COG1530	ribonuclease E activity
G9274_RS13630	COG2968	Membrane
G9274_RS13650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G9274_RS13660	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G9274_RS13675	COG0495	leucyl-tRNA aminoacylation
G9274_RS13685	COG3118	belongs to the thioredoxin family
G9274_RS13695	COG2203	Gaf domain
G9274_RS13695	COG5001	Diguanylate cyclase
G9274_RS13695	COG3706	GGDEF domain
G9274_RS13695	COG4251	negative regulation of phosphorylation
G9274_RS13715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G9274_RS13730	COG0346	lactoylglutathione lyase activity
G9274_RS13740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G9274_RS13740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G9274_RS13750	COG2878	Part of a membrane complex involved in electron transport
G9274_RS13755	COG0251	oxidation-reduction process
G9274_RS13760	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G9274_RS13760	COG0392	lysyltransferase activity
G9274_RS13790	COG2824	Alkylphosphonate utilization operon protein PhnA
G9274_RS13795	COG1077	Cell shape determining protein MreB Mrl
G9274_RS13835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G9274_RS13840	COG3122	Protein conserved in bacteria
G9274_RS13845	COG1451	nucleotide metabolic process
G9274_RS13855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G9274_RS13875	COG0183	Belongs to the thiolase family
G9274_RS13890	COG1960	acyl-CoA dehydrogenase activity
G9274_RS13895	COG1793	dna ligase
G9274_RS13895	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G9274_RS13900	COG1793	dna ligase
G9274_RS13920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G9274_RS13925	COG1278	Cold shock
G9274_RS13930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G9274_RS13940	COG1472	Belongs to the glycosyl hydrolase 3 family
G9274_RS13945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G9274_RS13950	COG2954	triphosphatase activity
G9274_RS13960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G9274_RS13965	COG0745	RESPONSE REGULATOR receiver
G9274_RS13975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G9274_RS13990	COG0681	Belongs to the peptidase S26 family
G9274_RS13995	COG0481	GTPase activity
G9274_RS14000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G9274_RS14015	COG1024	Enoyl-CoA hydratase
G9274_RS14015	COG1250	3-hydroxyacyl-CoA dehydrogenase
G9274_RS14020	COG1741	Belongs to the pirin family
G9274_RS14025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G9274_RS14040	COG1966	Carbon starvation protein
G9274_RS14045	COG2879	small protein
G9274_RS14090	COG2972	Histidine kinase
G9274_RS14110	COG2194	sulfuric ester hydrolase activity
G9274_RS14125	COG2814	Major facilitator Superfamily
G9274_RS14130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G9274_RS14130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G9274_RS14135	COG1113	amino acid transport
G9274_RS14140	COG1917	Cupin 2, conserved barrel domain protein
G9274_RS14140	COG2207	Transcriptional regulator
G9274_RS14145	COG0753	catalase activity
G9274_RS14170	COG0840	transmembrane signaling receptor activity
G9274_RS14175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G9274_RS14185	COG0330	HflC and HflK could
G9274_RS14190	COG0330	HflC and HflK could
G9274_RS14195	COG0604	alcohol dehydrogenase
G9274_RS14210	COG0678	peroxiredoxin activity
G9274_RS14220	COG4953	penicillin-binding protein 1C
G9274_RS14225	COG2373	Large extracellular alpha-helical protein
G9274_RS14230	COG2079	MmgE PrpD family protein
G9274_RS14235	COG2828	Protein conserved in bacteria
G9274_RS14240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G9274_RS14255	COG3829	transcription factor binding
G9274_RS14280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G9274_RS14300	COG2814	Major facilitator Superfamily
G9274_RS14315	COG5002	protein histidine kinase activity
G9274_RS14315	COG0784	Response regulator, receiver
G9274_RS14315	COG2205	protein histidine kinase activity
G9274_RS14325	COG2353	YceI-like domain
G9274_RS14330	COG3038	cytochrome b561
G9274_RS14345	COG1760	l-serine dehydratase
G9274_RS14355	COG0460	homoserine dehydrogenase
G9274_RS14355	COG0527	aspartate kinase activity
G9274_RS14360	COG0626	cystathionine gamma-synthase activity
G9274_RS14365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G9274_RS14370	COG0739	heme binding
G9274_RS14375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G9274_RS14380	COG1272	protein, Hemolysin III
G9274_RS14385	COG2982	Protein involved in outer membrane biogenesis
G9274_RS14395	COG0463	Glycosyl transferase, family 2
G9274_RS14405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G9274_RS14415	COG4206	TonB-dependent receptor
G9274_RS14420	COG1309	transcriptional regulator
G9274_RS14470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G9274_RS14480	COG0330	HflC and HflK could
G9274_RS14485	COG1742	UPF0060 membrane protein
G9274_RS14490	COG3956	TIGRFAM MazG family protein
G9274_RS14495	COG1218	3'(2'),5'-bisphosphate nucleotidase
G9274_RS14500	COG0494	nUDIX hydrolase
G9274_RS14510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G9274_RS14525	COG0643	Histidine kinase
G9274_RS14525	COG2198	Histidine kinase
G9274_RS14525	COG0784	Response regulator, receiver
G9274_RS14530	COG0840	transmembrane signaling receptor activity
G9274_RS14535	COG0835	chemotaxis
G9274_RS14550	COG0189	ligase activity
G9274_RS14565	COG1199	ATP-dependent helicase activity
G9274_RS14575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G9274_RS14595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G9274_RS14605	COG1643	Atp-dependent helicase
G9274_RS14610	COG0783	Belongs to the Dps family
G9274_RS14615	COG0514	ATP-dependent DNA helicase (RecQ)
G9274_RS14625	COG2132	Multicopper oxidase
G9274_RS14700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G9274_RS14705	COG0602	queuosine metabolic process
G9274_RS14715	COG2885	chlorophyll binding
G9274_RS14720	COG0823	Involved in the tonB-independent uptake of proteins
G9274_RS14740	COG0824	Thioesterase
G9274_RS14745	COG2255	four-way junction helicase activity
G9274_RS14755	COG0632	four-way junction helicase activity
G9274_RS14760	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G9274_RS14765	COG0217	transcriptional regulatory protein
G9274_RS14785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G9274_RS14820	COG0488	(ABC) transporter
G9274_RS14830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G9274_RS14830	COG4651	solute:proton antiporter activity
G9274_RS14845	COG0542	response to heat
G9274_RS14850	COG1595	DNA-templated transcription, initiation
G9274_RS14865	COG1858	cytochrome C peroxidase
G9274_RS14880	COG0028	Belongs to the TPP enzyme family
G9274_RS14900	COG1877	trehalose-phosphatase activity
G9274_RS14905	COG3387	PFAM Glycoside hydrolase 15-related
G9274_RS14910	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G9274_RS14930	COG0564	pseudouridine synthase activity
G9274_RS14935	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G9274_RS14940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G9274_RS14940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G9274_RS14945	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G9274_RS14950	COG0045	succinate-CoA ligase (ADP-forming) activity
G9274_RS14985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G9274_RS14990	COG0237	dephospho-CoA kinase activity
G9274_RS14995	COG5002	protein histidine kinase activity
G9274_RS15000	COG0745	RESPONSE REGULATOR receiver
G9274_RS15010	COG0189	ligase activity
G9274_RS15035	COG2022	thiamine diphosphate biosynthetic process
G9274_RS15040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G9274_RS15045	COG0471	metal ion transport
G9274_RS15045	COG3273	potassium ion transport
G9274_RS15060	COG0179	Fumarylacetoacetate (FAA) hydrolase
G9274_RS15065	COG1970	mechanosensitive ion channel activity
G9274_RS15075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G9274_RS15080	COG1115	amino acid carrier protein
G9274_RS15085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G9274_RS15115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G9274_RS15125	COG3588	fructose-bisphosphate aldolase
G9274_RS15130	COG0469	pyruvate kinase activity
G9274_RS15140	COG0126	phosphoglycerate kinase activity
G9274_RS15155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G9274_RS15160	COG3047	cAMP biosynthetic process
G9274_RS15165	COG1794	racemase activity, acting on amino acids and derivatives
G9274_RS15205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G9274_RS15215	COG1301	dicarboxylic acid transport
G9274_RS15245	COG0714	Associated with various cellular activities
G9274_RS15275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G9274_RS15315	COG0254	rRNA binding
G9274_RS15320	COG1957	nucleoside hydrolase
G9274_RS15325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G9274_RS15340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G9274_RS15345	COG1758	RNA polymerase activity
G9274_RS15355	COG1561	YicC-like family, N-terminal region
G9274_RS15360	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G9274_RS15365	COG0346	lactoylglutathione lyase activity
G9274_RS15380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G9274_RS15395	COG0006	proline dipeptidase activity
G9274_RS15400	COG0006	proline dipeptidase activity
G9274_RS15405	COG3079	Belongs to the UPF0149 family
G9274_RS15425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G9274_RS15435	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G9274_RS15445	COG2912	Transglutaminase-like superfamily
G9274_RS15450	COG1773	rubredoxin
G9274_RS15460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G9274_RS15465	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
G9274_RS15475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G9274_RS15480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G9274_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS15495	COG0586	Pfam SNARE associated Golgi protein
G9274_RS15505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G9274_RS15510	COG0563	adenylate kinase activity
G9274_RS15530	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G9274_RS15540	COG0848	biopolymer transport protein
G9274_RS15550	COG2832	Protein of unknown function (DUF454)
G9274_RS15600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G9274_RS15630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G9274_RS15635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G9274_RS15640	COG0405	Gamma-glutamyltransferase
G9274_RS15645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G9274_RS15665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G9274_RS15670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G9274_RS15685	COG0473	3-isopropylmalate dehydrogenase activity
G9274_RS15710	COG1538	Outer membrane efflux protein
G9274_RS15715	COG4774	siderophore transport
G9274_RS15725	COG1519	Transferase
G9274_RS15730	COG1560	Kdo2-lipid A biosynthetic process
G9274_RS15740	COG0297	glycogen (starch) synthase activity
G9274_RS15765	COG1301	dicarboxylic acid transport
G9274_RS15775	COG4191	Histidine kinase
G9274_RS15790	COG0642	Histidine kinase
G9274_RS15805	COG2851	Citrate transporter
G9274_RS15810	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS15815	COG3501	Rhs element vgr protein
G9274_RS15860	COG1162	GTPase activity
G9274_RS15865	COG0436	Aminotransferase
G9274_RS15885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G9274_RS15900	COG1228	amidohydrolase
G9274_RS15905	COG0402	S-adenosylhomocysteine deaminase activity
G9274_RS15915	COG1307	EDD domain protein, DegV family
G9274_RS15925	COG5001	Diguanylate cyclase
G9274_RS15925	COG4251	negative regulation of phosphorylation
G9274_RS15925	COG3706	GGDEF domain
G9274_RS15925	COG2203	Gaf domain
G9274_RS15940	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G9274_RS15945	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G9274_RS15965	COG0745	RESPONSE REGULATOR receiver
G9274_RS15970	COG5002	protein histidine kinase activity
G9274_RS16000	COG0583	DNA-binding transcription factor activity
G9274_RS16005	COG1064	alcohol dehydrogenase
G9274_RS16010	COG2076	Multidrug Resistance protein
G9274_RS16025	COG2207	Transcriptional regulator
G9274_RS16030	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G9274_RS16035	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G9274_RS16060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G9274_RS16070	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G9274_RS16075	COG5006	permease, DMT superfamily
G9274_RS16095	COG4773	Receptor
G9274_RS16105	COG1280	lysine exporter protein (LysE YggA)
G9274_RS16120	COG0617	tRNA 3'-terminal CCA addition
G9274_RS16125	COG1376	ErfK ybiS ycfS ynhG family protein
G9274_RS16130	COG0739	heme binding
G9274_RS16145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G9274_RS16150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G9274_RS16155	COG1609	Transcriptional regulator
G9274_RS16165	COG0837	glucose binding
G9274_RS16175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G9274_RS16195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G9274_RS16210	COG0784	Response regulator, receiver
G9274_RS16215	COG4251	negative regulation of phosphorylation
G9274_RS16220	COG2823	Periplasmic or secreted lipoprotein
G9274_RS16225	COG0673	inositol 2-dehydrogenase activity
G9274_RS16230	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G9274_RS16250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G9274_RS16255	COG0321	lipoyl(octanoyl) transferase activity
G9274_RS16260	COG2921	Belongs to the UPF0250 family
G9274_RS16275	COG1686	Belongs to the peptidase S11 family
G9274_RS16280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G9274_RS16285	COG2951	lytic endotransglycosylase activity
G9274_RS16310	COG0772	Belongs to the SEDS family
G9274_RS16315	COG0768	penicillin binding
G9274_RS16325	COG1792	Involved in formation and maintenance of cell shape
G9274_RS16330	COG1077	Cell shape determining protein MreB Mrl
G9274_RS16335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G9274_RS16340	COG0546	phosphoglycolate phosphatase activity
G9274_RS16350	COG0308	aminopeptidase N
G9274_RS16355	COG5001	Diguanylate cyclase
G9274_RS16360	COG2226	methyltransferase
G9274_RS16390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G9274_RS16395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G9274_RS16400	COG1309	transcriptional regulator
G9274_RS16435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G9274_RS16450	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G9274_RS16460	COG2832	Protein of unknown function (DUF454)
G9274_RS16475	COG1505	serine-type exopeptidase activity
G9274_RS16490	COG2011	ABC-type metal ion transport system permease component
G9274_RS16500	COG0697	spore germination
G9274_RS16535	COG0339	signal peptide processing
G9274_RS16540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G9274_RS16565	COG1573	uracil-dna glycosylase
G9274_RS16570	COG0517	IMP dehydrogenase activity
G9274_RS16580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G9274_RS16590	COG1136	(ABC) transporter
G9274_RS16600	COG1136	(ABC) transporter
G9274_RS16600	COG0577	efflux transmembrane transporter activity
G9274_RS16605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G9274_RS16615	COG4191	Histidine kinase
G9274_RS16620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G9274_RS16630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G9274_RS16635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G9274_RS16645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G9274_RS16650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G9274_RS16655	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G9274_RS16665	COG0356	it plays a direct role in the translocation of protons across the membrane
G9274_RS16680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G9274_RS16690	COG0508	dehydrogenase complex catalyzes the overall conversion of
G9274_RS16710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G9274_RS16735	COG0181	hydroxymethylbilane synthase activity
G9274_RS16745	COG3275	phosphorelay sensor kinase activity
G9274_RS16770	COG1393	Belongs to the ArsC family
G9274_RS16775	COG0431	NADPH-dependent FMN reductase
G9274_RS16785	COG0798	PFAM Bile acid sodium symporter
G9274_RS16795	COG0840	transmembrane signaling receptor activity
G9274_RS16800	COG0659	secondary active sulfate transmembrane transporter activity
G9274_RS16810	COG0697	spore germination
G9274_RS16815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G9274_RS16825	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
G9274_RS16835	COG0745	RESPONSE REGULATOR receiver
G9274_RS16840	COG2205	protein histidine kinase activity
G9274_RS16850	COG2194	sulfuric ester hydrolase activity
G9274_RS16875	COG3550	peptidyl-serine autophosphorylation
G9274_RS16880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G9274_RS16885	COG1490	D-aminoacyl-tRNA deacylase activity
G9274_RS16930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G9274_RS16930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G9274_RS16935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G9274_RS16940	COG0242	peptide deformylase activity
G9274_RS16950	COG0758	DNA mediated transformation
G9274_RS16955	COG2922	Belongs to the Smg family
G9274_RS16965	COG1714	RDD family
G9274_RS16975	COG0009	L-threonylcarbamoyladenylate synthase
G9274_RS16995	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS17005	COG0616	signal peptide processing
G9274_RS17010	COG0534	Mate efflux family protein
G9274_RS17025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G9274_RS17035	COG0625	glutathione transferase activity
G9274_RS17045	COG1252	NADH dehydrogenase
G9274_RS17085	COG2860	membrane
G9274_RS17095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G9274_RS17105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G9274_RS17115	COG1846	Transcriptional regulator
G9274_RS17120	COG2205	protein histidine kinase activity
G9274_RS17125	COG0745	RESPONSE REGULATOR receiver
G9274_RS17135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G9274_RS17150	COG0459	protein refolding
G9274_RS17155	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G9274_RS17160	COG2356	endonuclease I
G9274_RS17165	COG1324	tolerance protein
G9274_RS17175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G9274_RS17185	COG0840	transmembrane signaling receptor activity
G9274_RS17220	COG2197	response regulator
G9274_RS17225	COG4585	Histidine kinase
G9274_RS17260	COG3279	Response regulator of the LytR AlgR family
G9274_RS17280	COG2249	NAD(P)H dehydrogenase (quinone) activity
G9274_RS17290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G9274_RS17300	COG0511	ligase activity, forming carbon-carbon bonds
G9274_RS17305	COG0439	Biotin carboxylase
G9274_RS17325	COG2264	protein methyltransferase activity
G9274_RS17335	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G9274_RS17340	COG4589	Belongs to the CDS family
G9274_RS17355	COG2453	phosphatase
G9274_RS17355	COG0671	phosphoesterase, PA-phosphatase related
G9274_RS17360	COG2267	carboxylic ester hydrolase activity
G9274_RS17365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G9274_RS17370	COG0138	bifunctional purine biosynthesis protein purh
G9274_RS17385	COG0151	Belongs to the GarS family
G9274_RS17395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G9274_RS17400	COG2201	protein-glutamate methylesterase activity
G9274_RS17405	COG2177	Part of the ABC transporter FtsEX involved in
G9274_RS17410	COG2884	Cell division ATP-binding protein ftsE
G9274_RS17415	COG0513	Belongs to the DEAD box helicase family
G9274_RS17420	COG3118	belongs to the thioredoxin family
G9274_RS17425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G9274_RS17440	COG1472	Belongs to the glycosyl hydrolase 3 family
G9274_RS17465	COG3706	GGDEF domain
G9274_RS17475	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G9274_RS17510	COG1652	LysM domain
G9274_RS17515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G9274_RS17515	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G9274_RS17520	COG1473	amidohydrolase
G9274_RS17530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G9274_RS17545	COG1289	transmembrane transporter activity
G9274_RS17570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G9274_RS17580	COG0316	Belongs to the HesB IscA family
G9274_RS17610	COG2193	ferroxidase activity
G9274_RS17620	COG1051	belongs to the nudix hydrolase family
G9274_RS17635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G9274_RS17640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G9274_RS17645	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G9274_RS17655	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G9274_RS17660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G9274_RS17665	COG0730	response to heat
G9274_RS17675	COG0134	indole-3-glycerol-phosphate synthase activity
G9274_RS17680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G9274_RS17710	COG1597	lipid kinase activity
G9274_RS17735	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G9274_RS17740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G9274_RS17750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G9274_RS17750	COG2111	Na H antiporter
G9274_RS17755	COG1006	Multisubunit Na H antiporter MnhC subunit
G9274_RS17760	COG0651	ATP synthesis coupled electron transport
G9274_RS17765	COG1863	multisubunit Na H antiporter MnhE subunit
G9274_RS17770	COG2212	antiporter activity
G9274_RS17775	COG1320	monovalent cation:proton antiporter activity
G9274_RS17780	COG0530	calcium, potassium:sodium antiporter activity
G9274_RS17795	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G9274_RS17820	COG3104	oligopeptide transport
G9274_RS17825	COG3483	tryptophan 2,3-dioxygenase activity
G9274_RS17830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G9274_RS17850	COG0702	epimerase
G9274_RS17870	COG2354	Protein conserved in bacteria
G9274_RS17875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G9274_RS17885	COG3264	Mechanosensitive ion channel
G9274_RS17885	COG1196	nuclear chromosome segregation
G9274_RS17900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G9274_RS17920	COG0745	RESPONSE REGULATOR receiver
G9274_RS17925	COG2205	protein histidine kinase activity
G9274_RS17935	COG1166	arginine decarboxylase activity
G9274_RS17940	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G9274_RS17965	COG0606	chelatase, subunit chli
G9274_RS18000	COG2031	fatty acid transporter
G9274_RS18040	COG0673	inositol 2-dehydrogenase activity
G9274_RS18045	COG4771	TonB-dependent receptor
G9274_RS18055	COG2222	sugar isomerase
G9274_RS18060	COG1940	carbohydrate kinase activity
G9274_RS18070	COG1349	DNA-binding transcription factor activity
G9274_RS18075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G9274_RS18080	COG2814	Major facilitator Superfamily
G9274_RS18095	COG1040	competence protein
G9274_RS18100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G9274_RS18110	COG2267	carboxylic ester hydrolase activity
G9274_RS18115	COG1028	Short-chain dehydrogenase reductase Sdr
G9274_RS18145	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G9274_RS18170	COG0714	Associated with various cellular activities
G9274_RS18185	COG0754	glutathionylspermidine amidase activity
G9274_RS18195	COG0129	dihydroxy-acid dehydratase activity
G9274_RS18200	COG1199	ATP-dependent helicase activity
G9274_RS18210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G9274_RS18230	COG3781	membrane
G9274_RS18260	COG0625	glutathione transferase activity
G9274_RS18315	COG1668	transmembrane transport
G9274_RS18320	COG4555	ABC transporter
G9274_RS18340	COG1131	(ABC) transporter
G9274_RS18345	COG0842	Transport permease protein
G9274_RS18350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G9274_RS18360	COG0084	hydrolase, TatD family'
G9274_RS18370	COG1643	Atp-dependent helicase
G9274_RS18380	COG1187	pseudouridine synthase activity
G9274_RS18390	COG0667	Aldo Keto reductase
G9274_RS18405	COG1690	Belongs to the RtcB family
G9274_RS18410	COG3634	alkyl hydroperoxide reductase activity
G9274_RS18415	COG1959	2 iron, 2 sulfur cluster binding
G9274_RS18420	COG0840	transmembrane signaling receptor activity
G9274_RS18425	COG0583	DNA-binding transcription factor activity
G9274_RS18430	COG2814	Major facilitator Superfamily
G9274_RS18435	COG0656	L-ascorbic acid biosynthetic process
G9274_RS18440	COG2267	carboxylic ester hydrolase activity
G9274_RS18465	COG2239	Acts as a magnesium transporter
G9274_RS18470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G9274_RS18470	COG0475	glutathione-regulated potassium exporter activity
G9274_RS18485	COG0251	oxidation-reduction process
G9274_RS18490	COG1294	oxidase, subunit
G9274_RS18495	COG1271	oxidase subunit
G9274_RS18530	COG3501	Rhs element vgr protein
G9274_RS18540	COG0494	nUDIX hydrolase
G9274_RS18560	COG0408	coproporphyrinogen oxidase activity
G9274_RS18565	COG2323	membrane
G9274_RS18585	COG0589	response to stress
G9274_RS18610	COG0210	DNA helicase
G9274_RS18620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G9274_RS18625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G9274_RS18630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G9274_RS18635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G9274_RS18690	COG0463	Glycosyl transferase, family 2
G9274_RS18705	COG1475	DNA binding
G9274_RS18710	COG1192	Involved in chromosome partitioning
G9274_RS18715	COG0357	Ribosomal RNA small subunit methyltransferase G
G9274_RS18760	COG1971	Probably functions as a manganese efflux pump
G9274_RS18765	COG0784	Response regulator, receiver
G9274_RS18765	COG2205	protein histidine kinase activity
G9274_RS18775	COG3706	GGDEF domain
G9274_RS18810	COG0729	surface antigen
G9274_RS18820	COG0752	glycyl-tRNA synthetase alpha subunit
G9274_RS18850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G9274_RS18860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G9274_RS18870	COG0840	transmembrane signaling receptor activity
G9274_RS18925	COG3135	benzoate transporter
G9274_RS18935	COG0676	glucose-6-phosphate 1-epimerase activity
G9274_RS18940	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
G9274_RS18945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G9274_RS18945	COG0515	serine threonine protein kinase
G9274_RS18980	COG0302	gtp cyclohydrolase
G9274_RS18995	COG1566	PFAM secretion protein HlyD family protein
G9274_RS19005	COG1289	transmembrane transporter activity
G9274_RS19075	COG1074	ATP-dependent DNA helicase activity
G9274_RS19080	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G9274_RS19085	COG1127	ABC transporter
G9274_RS19090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G9274_RS19095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G9274_RS19110	COG2853	Lipoprotein
G9274_RS19145	COG0386	Belongs to the glutathione peroxidase family
G9274_RS19155	COG1322	Protein conserved in bacteria
G9274_RS19160	COG0778	Nitroreductase
G9274_RS19170	COG0583	DNA-binding transcription factor activity
G9274_RS19190	COG0667	Aldo Keto reductase
G9274_RS19195	COG0531	amino acid
G9274_RS19205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G9274_RS19210	COG0861	Integral membrane protein TerC family
G9274_RS19220	COG0584	glycerophosphoryl diester phosphodiesterase
G9274_RS19230	COG0706	membrane insertase activity
G9274_RS19235	COG0594	ribonuclease P activity
G9274_RS19240	COG0230	Belongs to the bacterial ribosomal protein bL34 family