locus-tag	class	description
H7691_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7691_RS00010	COG0592	DNA-directed DNA polymerase activity
H7691_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7691_RS00020	COG0187	DNA topoisomerase II activity
H7691_RS00030	COG0501	Belongs to the peptidase M48B family
H7691_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7691_RS00080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7691_RS00095	COG4772	TonB-dependent receptor
H7691_RS00105	COG0800	Aldolase
H7691_RS00110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7691_RS00115	COG4771	TonB-dependent receptor
H7691_RS00130	COG2272	Belongs to the type-B carboxylesterase lipase family
H7691_RS00145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7691_RS00160	COG1609	Transcriptional regulator
H7691_RS00165	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS00175	COG0302	gtp cyclohydrolase
H7691_RS00180	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H7691_RS00190	COG4206	TonB-dependent receptor
H7691_RS00210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7691_RS00215	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H7691_RS00220	COG0676	glucose-6-phosphate 1-epimerase activity
H7691_RS00225	COG3135	benzoate transporter
H7691_RS00260	COG1803	Methylglyoxal synthase
H7691_RS00265	COG0493	'glutamate synthase
H7691_RS00270	COG0070	glutamate synthase
H7691_RS00270	COG0067	glutamate synthase
H7691_RS00270	COG0069	glutamate synthase activity
H7691_RS00305	COG1205	dead DEAH box helicase
H7691_RS00305	COG1111	helicase
H7691_RS00335	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7691_RS00340	COG2885	chlorophyll binding
H7691_RS00370	COG0714	Associated with various cellular activities
H7691_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7691_RS00430	COG2062	phosphohistidine phosphatase, SixA
H7691_RS00440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7691_RS00460	COG2202	Pas domain
H7691_RS00460	COG2200	EAL domain
H7691_RS00460	COG2199	diguanylate cyclase activity
H7691_RS00490	COG1968	undecaprenyl-diphosphatase activity
H7691_RS00495	COG0174	glutamine synthetase
H7691_RS00505	COG0004	ammonium transporteR
H7691_RS00510	COG3852	Histidine kinase
H7691_RS00515	COG2204	response regulator
H7691_RS00520	COG0515	serine threonine protein kinase
H7691_RS00520	COG2815	serine threonine protein kinase
H7691_RS00525	COG2032	superoxide dismutase activity
H7691_RS00530	COG2032	superoxide dismutase activity
H7691_RS00540	COG0183	Belongs to the thiolase family
H7691_RS00585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7691_RS00590	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7691_RS00595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7691_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS00635	COG3474	cytochrome
H7691_RS00650	COG0454	-acetyltransferase
H7691_RS00700	COG0129	dihydroxy-acid dehydratase activity
H7691_RS00710	COG0754	glutathionylspermidine amidase activity
H7691_RS00725	COG0714	Associated with various cellular activities
H7691_RS00755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7691_RS00810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7691_RS00840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7691_RS00845	COG1040	competence protein
H7691_RS00855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7691_RS00865	COG2207	Transcriptional regulator
H7691_RS00875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7691_RS00925	COG0606	chelatase, subunit chli
H7691_RS00930	COG2960	long-chain fatty acid transporting porin activity
H7691_RS00955	COG1166	arginine decarboxylase activity
H7691_RS00960	COG4221	oxidoreductase activity
H7691_RS00970	COG0018	arginyl-trna synthetase
H7691_RS00980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7691_RS01000	COG2205	protein histidine kinase activity
H7691_RS01010	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H7691_RS01015	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H7691_RS01035	COG0708	Exodeoxyribonuclease III
H7691_RS01040	COG2223	nitrite transmembrane transporter activity
H7691_RS01055	COG0739	heme binding
H7691_RS01060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7691_RS01100	COG4942	peptidase
H7691_RS01105	COG0793	Belongs to the peptidase S41A family
H7691_RS01140	COG1565	acr, cog1565
H7691_RS01140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7691_RS01145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7691_RS01150	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H7691_RS01195	COG0358	DNA primase activity
H7691_RS01200	COG1295	ribonuclease BN
H7691_RS01205	COG1610	YqeY-like protein
H7691_RS01215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7691_RS01220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7691_RS01225	COG0668	transmembrane transport
H7691_RS01240	COG2133	pyrroloquinoline quinone binding
H7691_RS01245	COG1301	dicarboxylic acid transport
H7691_RS01255	COG1737	Transcriptional regulator
H7691_RS01260	COG4948	Mandelate Racemase Muconate Lactonizing
H7691_RS01280	COG0019	diaminopimelate decarboxylase activity
H7691_RS01285	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7691_RS01300	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7691_RS01305	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H7691_RS01310	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H7691_RS01335	COG5383	Protein conserved in bacteria
H7691_RS01345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7691_RS01350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7691_RS01355	COG1473	amidohydrolase
H7691_RS01360	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7691_RS01360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7691_RS01365	COG1652	LysM domain
H7691_RS01390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H7691_RS01395	COG3118	belongs to the thioredoxin family
H7691_RS01405	COG2884	Cell division ATP-binding protein ftsE
H7691_RS01410	COG2177	Part of the ABC transporter FtsEX involved in
H7691_RS01415	COG2201	protein-glutamate methylesterase activity
H7691_RS01420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7691_RS01425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7691_RS01435	COG1252	NADH dehydrogenase
H7691_RS01445	COG0625	glutathione transferase activity
H7691_RS01455	COG3537	Alpha-1,2-mannosidase
H7691_RS01460	COG1609	Transcriptional regulator
H7691_RS01470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7691_RS01480	COG3250	beta-galactosidase activity
H7691_RS01500	COG4585	Histidine kinase
H7691_RS01515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7691_RS01530	COG0534	Mate efflux family protein
H7691_RS01535	COG0616	signal peptide processing
H7691_RS01545	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS01555	COG0745	RESPONSE REGULATOR receiver
H7691_RS01570	COG0009	L-threonylcarbamoyladenylate synthase
H7691_RS01575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7691_RS01575	COG1754	DNA topoisomerase type I activity
H7691_RS01580	COG1714	RDD family
H7691_RS01590	COG2922	Belongs to the Smg family
H7691_RS01595	COG0758	DNA mediated transformation
H7691_RS01605	COG0242	peptide deformylase activity
H7691_RS01610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7691_RS01615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7691_RS01615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7691_RS01625	COG1215	transferase activity, transferring glycosyl groups
H7691_RS01660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7691_RS01670	COG1490	D-aminoacyl-tRNA deacylase activity
H7691_RS01675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7691_RS01680	COG3537	Alpha-1,2-mannosidase
H7691_RS01690	COG0582	viral genome integration into host DNA
H7691_RS01695	COG1309	transcriptional regulator
H7691_RS01710	COG1764	response to oxidative stress
H7691_RS01725	COG4716	Myosin-crossreactive antigen
H7691_RS01730	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7691_RS01770	COG3275	phosphorelay sensor kinase activity
H7691_RS01785	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H7691_RS01810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7691_RS01820	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H7691_RS01830	COG1595	DNA-templated transcription, initiation
H7691_RS01840	COG0302	gtp cyclohydrolase
H7691_RS01845	COG3046	protein related to deoxyribodipyrimidine photolyase
H7691_RS01870	COG2200	EAL domain
H7691_RS01875	COG3706	GGDEF domain
H7691_RS01890	COG5002	protein histidine kinase activity
H7691_RS01890	COG5001	Diguanylate cyclase
H7691_RS01925	COG3795	YCII-related domain
H7691_RS01930	COG3795	YCII-related domain
H7691_RS01945	COG5507	3-demethylubiquinone-9 3-methyltransferase
H7691_RS01950	COG4941	Belongs to the sigma-70 factor family
H7691_RS01960	COG2972	Histidine kinase
H7691_RS01985	COG3590	peptidase
H7691_RS01990	COG5001	Diguanylate cyclase
H7691_RS01995	COG0583	DNA-binding transcription factor activity
H7691_RS02000	COG3384	dioxygenase
H7691_RS02005	COG0025	NhaP-type Na H and K H
H7691_RS02055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7691_RS02070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7691_RS02070	COG2205	protein histidine kinase activity
H7691_RS02080	COG1187	pseudouridine synthase activity
H7691_RS02085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7691_RS02095	COG1666	GTP binding
H7691_RS02105	COG0697	spore germination
H7691_RS02115	COG2011	ABC-type metal ion transport system permease component
H7691_RS02145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7691_RS02160	COG0356	it plays a direct role in the translocation of protons across the membrane
H7691_RS02170	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7691_RS02175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7691_RS02180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7691_RS02185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7691_RS02190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7691_RS02195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7691_RS02205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7691_RS02210	COG4191	Histidine kinase
H7691_RS02220	COG1136	(ABC) transporter
H7691_RS02220	COG0577	efflux transmembrane transporter activity
H7691_RS02240	COG0577	efflux transmembrane transporter activity
H7691_RS02240	COG1136	(ABC) transporter
H7691_RS02245	COG0577	efflux transmembrane transporter activity
H7691_RS02245	COG1136	(ABC) transporter
H7691_RS02250	COG0577	efflux transmembrane transporter activity
H7691_RS02250	COG1136	(ABC) transporter
H7691_RS02255	COG1136	(ABC) transporter
H7691_RS02255	COG0577	efflux transmembrane transporter activity
H7691_RS02260	COG1136	(ABC) transporter
H7691_RS02260	COG0577	efflux transmembrane transporter activity
H7691_RS02265	COG1136	(ABC) transporter
H7691_RS02275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7691_RS02335	COG2132	Multicopper oxidase
H7691_RS02350	COG0339	signal peptide processing
H7691_RS02395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7691_RS02400	COG0546	phosphoglycolate phosphatase activity
H7691_RS02405	COG4206	TonB-dependent receptor
H7691_RS02410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H7691_RS02415	COG0406	alpha-ribazole phosphatase activity
H7691_RS02420	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H7691_RS02430	COG1956	GAF domain-containing protein
H7691_RS02440	COG0720	synthase
H7691_RS02445	COG0513	Belongs to the DEAD box helicase family
H7691_RS02455	COG0625	glutathione transferase activity
H7691_RS02485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7691_RS02490	COG1459	type II secretion system
H7691_RS02545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7691_RS02545	COG2755	lipolytic protein G-D-S-L family
H7691_RS02550	COG0626	cystathionine gamma-synthase activity
H7691_RS02575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7691_RS02580	COG2076	Multidrug Resistance protein
H7691_RS02595	COG0318	PFAM AMP-dependent synthetase and ligase
H7691_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS02655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7691_RS02675	COG2409	Drug exporters of the RND superfamily
H7691_RS02695	COG0181	hydroxymethylbilane synthase activity
H7691_RS02720	COG0826	peptidase U32
H7691_RS02725	COG0826	peptidase U32
H7691_RS02730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7691_RS02740	COG3154	lipid carrier protein
H7691_RS02760	COG1505	serine-type exopeptidase activity
H7691_RS02765	COG0436	Aminotransferase
H7691_RS02775	COG2832	Protein of unknown function (DUF454)
H7691_RS02785	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7691_RS02810	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7691_RS02815	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7691_RS02820	COG1309	transcriptional regulator
H7691_RS02825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7691_RS02830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7691_RS02845	COG2226	methyltransferase
H7691_RS02850	COG0308	aminopeptidase N
H7691_RS02870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7691_RS02875	COG1077	Cell shape determining protein MreB Mrl
H7691_RS02880	COG1792	Involved in formation and maintenance of cell shape
H7691_RS02890	COG0768	penicillin binding
H7691_RS02895	COG0772	Belongs to the SEDS family
H7691_RS02900	COG2951	lytic endotransglycosylase activity
H7691_RS02910	COG1686	Belongs to the peptidase S11 family
H7691_RS02925	COG2921	Belongs to the UPF0250 family
H7691_RS02930	COG0321	lipoyl(octanoyl) transferase activity
H7691_RS02935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7691_RS02955	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H7691_RS02965	COG4251	negative regulation of phosphorylation
H7691_RS02970	COG0784	Response regulator, receiver
H7691_RS02975	COG4191	Histidine kinase
H7691_RS02980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7691_RS03000	COG0662	Cupin 2, conserved barrel domain protein
H7691_RS03005	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H7691_RS03010	COG3876	Protein conserved in bacteria
H7691_RS03015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H7691_RS03025	COG0837	glucose binding
H7691_RS03030	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H7691_RS03040	COG0837	glucose binding
H7691_RS03045	COG0738	Major facilitator superfamily
H7691_RS03050	COG1609	Transcriptional regulator
H7691_RS03055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7691_RS03060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7691_RS03075	COG0617	tRNA 3'-terminal CCA addition
H7691_RS03100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7691_RS03115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7691_RS03120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7691_RS03165	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H7691_RS03170	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H7691_RS03175	COG5001	Diguanylate cyclase
H7691_RS03175	COG4251	negative regulation of phosphorylation
H7691_RS03175	COG3706	GGDEF domain
H7691_RS03175	COG2203	Gaf domain
H7691_RS03190	COG1307	EDD domain protein, DegV family
H7691_RS03195	COG1228	amidohydrolase
H7691_RS03200	COG3964	amidohydrolase
H7691_RS03210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7691_RS03220	COG0513	Belongs to the DEAD box helicase family
H7691_RS03240	COG0436	Aminotransferase
H7691_RS03245	COG1162	GTPase activity
H7691_RS03255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7691_RS03260	COG4206	TonB-dependent receptor
H7691_RS03270	COG0583	DNA-binding transcription factor activity
H7691_RS03275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7691_RS03280	COG0405	Gamma-glutamyltransferase
H7691_RS03290	COG0281	malic enzyme
H7691_RS03290	COG0280	phosphate acetyltransferase
H7691_RS03295	COG3119	arylsulfatase activity
H7691_RS03300	COG0641	radical SAM
H7691_RS03305	COG0405	Gamma-glutamyltransferase
H7691_RS03310	COG0786	glutamate:sodium symporter activity
H7691_RS03320	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
H7691_RS03325	COG1737	Transcriptional regulator
H7691_RS03330	COG2610	gluconate transmembrane transporter activity
H7691_RS03345	COG2197	response regulator
H7691_RS03355	COG3916	Acyl-homoserine-lactone synthase
H7691_RS03365	COG0297	glycogen (starch) synthase activity
H7691_RS03375	COG1560	Kdo2-lipid A biosynthetic process
H7691_RS03380	COG1519	Transferase
H7691_RS03385	COG1538	Outer membrane efflux protein
H7691_RS03390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7691_RS03440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7691_RS03440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7691_RS03500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7691_RS03505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7691_RS03525	COG1295	ribonuclease BN
H7691_RS03530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7691_RS03560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7691_RS03565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7691_RS03580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7691_RS03590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7691_RS03600	COG0193	aminoacyl-tRNA hydrolase activity
H7691_RS03605	COG0012	GTP binding
H7691_RS03610	COG4206	TonB-dependent receptor
H7691_RS03620	COG1446	asparaginase
H7691_RS03640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7691_RS03655	COG0250	Participates in transcription elongation, termination and antitermination
H7691_RS03660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7691_RS03665	COG0081	regulation of translation
H7691_RS03670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7691_RS03675	COG0222	ribosome binding
H7691_RS03680	COG0085	RNA polymerase activity
H7691_RS03685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7691_RS03690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7691_RS03700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7691_RS03705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7691_RS03715	COG0051	transcription antitermination factor activity, RNA binding
H7691_RS03720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7691_RS03725	COG0088	Forms part of the polypeptide exit tunnel
H7691_RS03730	COG0089	rRNA binding
H7691_RS03735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7691_RS03740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7691_RS03745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7691_RS03750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7691_RS03755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7691_RS03760	COG0255	Belongs to the universal ribosomal protein uL29 family
H7691_RS03765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7691_RS03775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7691_RS03780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7691_RS03785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7691_RS03790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7691_RS03800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7691_RS03805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7691_RS03810	COG1841	ribosomal large subunit assembly
H7691_RS03815	COG0200	Binds to the 23S rRNA
H7691_RS03820	COG0201	protein transport
H7691_RS03825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7691_RS03835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7691_RS03840	COG0202	RNA polymerase activity
H7691_RS03845	COG0203	ribosomal protein L17
H7691_RS03850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7691_RS03855	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H7691_RS03865	COG0154	amidase activity
H7691_RS03875	COG1217	gtp-binding protein TYPA
H7691_RS03880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7691_RS03895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7691_RS03910	COG2205	protein histidine kinase activity
H7691_RS03915	COG0745	RESPONSE REGULATOR receiver
H7691_RS03930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7691_RS03935	COG0625	glutathione transferase activity
H7691_RS03945	COG1902	pentaerythritol trinitrate reductase activity
H7691_RS03945	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7691_RS03965	COG1187	pseudouridine synthase activity
H7691_RS03985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7691_RS03990	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7691_RS03995	COG4208	sulfate ABC transporter
H7691_RS04000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7691_RS04015	COG1063	alcohol dehydrogenase
H7691_RS04030	COG0588	phosphoglycerate mutase activity
H7691_RS04040	COG0285	dihydrofolate synthase activity
H7691_RS04060	COG2833	Protein of unknown function (DUF455)
H7691_RS04075	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7691_RS04085	COG0438	transferase activity, transferring glycosyl groups
H7691_RS04090	COG0248	Ppx GppA phosphatase
H7691_RS04095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7691_RS04100	COG5002	protein histidine kinase activity
H7691_RS04110	COG4783	chaperone-mediated protein folding
H7691_RS04125	COG0473	3-isopropylmalate dehydrogenase activity
H7691_RS04165	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7691_RS04175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7691_RS04210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7691_RS04215	COG1388	LysM domain
H7691_RS04215	COG3942	CHAP domain
H7691_RS04220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7691_RS04235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7691_RS04240	COG0631	protein serine/threonine phosphatase activity
H7691_RS04255	COG0859	PFAM glycosyl transferase family 9
H7691_RS04260	COG3642	lipopolysaccharide core region biosynthetic process
H7691_RS04265	COG1234	tRNA 3'-trailer cleavage
H7691_RS04275	COG0582	viral genome integration into host DNA
H7691_RS04305	COG0587	DNA-directed DNA polymerase activity
H7691_RS04340	COG5377	YqaJ viral recombinase family
H7691_RS04390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7691_RS04405	COG0537	adenosine 5'-monophosphoramidase activity
H7691_RS04420	COG1305	Transglutaminase-like
H7691_RS04430	COG0714	Associated with various cellular activities
H7691_RS04455	COG1399	metal-binding, possibly nucleic acid-binding protein
H7691_RS04460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7691_RS04465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7691_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS04490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7691_RS04495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7691_RS04500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7691_RS04530	COG3540	Alkaline phosphatase
H7691_RS04590	COG2818	Glycosylase
H7691_RS04605	COG0540	Belongs to the ATCase OTCase family
H7691_RS04620	COG2239	Acts as a magnesium transporter
H7691_RS04625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7691_RS04640	COG1660	Displays ATPase and GTPase activities
H7691_RS04645	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H7691_RS04650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7691_RS04665	COG1137	ATPase activity
H7691_RS04680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7691_RS04695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7691_RS04705	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7691_RS04710	COG0564	pseudouridine synthase activity
H7691_RS04725	COG3011	Protein conserved in bacteria
H7691_RS04730	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H7691_RS04735	COG3387	PFAM Glycoside hydrolase 15-related
H7691_RS04740	COG1877	trehalose-phosphatase activity
H7691_RS04790	COG4771	TonB-dependent receptor
H7691_RS04800	COG1595	DNA-templated transcription, initiation
H7691_RS04805	COG0542	response to heat
H7691_RS04820	COG0583	DNA-binding transcription factor activity
H7691_RS04825	COG4651	solute:proton antiporter activity
H7691_RS04825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7691_RS04830	COG4771	TonB-dependent receptor
H7691_RS04835	COG0488	(ABC) transporter
H7691_RS04870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7691_RS04900	COG0217	transcriptional regulatory protein
H7691_RS04905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7691_RS04910	COG0632	four-way junction helicase activity
H7691_RS04920	COG2255	four-way junction helicase activity
H7691_RS04925	COG0824	Thioesterase
H7691_RS04950	COG2885	chlorophyll binding
H7691_RS04960	COG0602	queuosine metabolic process
H7691_RS04965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7691_RS04980	COG2815	serine threonine protein kinase
H7691_RS04980	COG0515	serine threonine protein kinase
H7691_RS04990	COG0783	Belongs to the Dps family
H7691_RS04995	COG1643	Atp-dependent helicase
H7691_RS05010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7691_RS05025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7691_RS05035	COG1199	ATP-dependent helicase activity
H7691_RS05040	COG1214	PFAM Peptidase M22, glycoprotease
H7691_RS05050	COG0384	phenazine biosynthesis protein PhzF
H7691_RS05055	COG0384	phenazine biosynthesis protein PhzF
H7691_RS05060	COG0527	aspartate kinase activity
H7691_RS05070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7691_RS05080	COG0142	geranyltranstransferase activity
H7691_RS05085	COG0366	Alpha amylase catalytic
H7691_RS05095	COG1082	Xylose isomerase domain protein TIM barrel
H7691_RS05100	COG2190	(PTS) system
H7691_RS05100	COG2211	Major facilitator Superfamily
H7691_RS05130	COG0629	single-stranded DNA binding
H7691_RS05150	COG0431	NADPH-dependent FMN reductase
H7691_RS05165	COG0798	PFAM Bile acid sodium symporter
H7691_RS05175	COG2197	response regulator
H7691_RS05185	COG4948	Mandelate Racemase Muconate Lactonizing
H7691_RS05195	COG4771	TonB-dependent receptor
H7691_RS05205	COG3104	oligopeptide transport
H7691_RS05210	COG1297	OPT oligopeptide transporter protein
H7691_RS05215	COG0823	Involved in the tonB-independent uptake of proteins
H7691_RS05215	COG1506	peptidase
H7691_RS05230	COG2879	small protein
H7691_RS05235	COG1966	Carbon starvation protein
H7691_RS05250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7691_RS05255	COG1741	Belongs to the pirin family
H7691_RS05260	COG1515	deoxyribonuclease V activity
H7691_RS05265	COG0588	phosphoglycerate mutase activity
H7691_RS05295	COG3590	peptidase
H7691_RS05315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7691_RS05325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7691_RS05330	COG0745	RESPONSE REGULATOR receiver
H7691_RS05335	COG2205	protein histidine kinase activity
H7691_RS05340	COG5002	protein histidine kinase activity
H7691_RS05340	COG5001	Diguanylate cyclase
H7691_RS05345	COG4452	Inner membrane protein CreD
H7691_RS05380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7691_RS05390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7691_RS05400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7691_RS05410	COG0728	peptidoglycan biosynthetic process
H7691_RS05415	COG0196	riboflavin kinase activity
H7691_RS05420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7691_RS05430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7691_RS05455	COG4206	TonB-dependent receptor
H7691_RS05480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7691_RS05485	COG1845	cytochrome c oxidase, subunit III
H7691_RS05490	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7691_RS05515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7691_RS05520	COG2070	2-Nitropropane dioxygenase
H7691_RS05535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7691_RS05540	COG0336	Belongs to the RNA methyltransferase TrmD family
H7691_RS05545	COG0335	large ribosomal subunit rRNA binding
H7691_RS05550	COG1349	DNA-binding transcription factor activity
H7691_RS05560	COG1940	carbohydrate kinase activity
H7691_RS05565	COG2222	sugar isomerase
H7691_RS05570	COG1501	Belongs to the glycosyl hydrolase 31 family
H7691_RS05580	COG0673	inositol 2-dehydrogenase activity
H7691_RS05585	COG0534	Mate efflux family protein
H7691_RS05605	COG0753	catalase activity
H7691_RS05615	COG1827	regulation of RNA biosynthetic process
H7691_RS05645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7691_RS05650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7691_RS05655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7691_RS05670	COG3706	GGDEF domain
H7691_RS05675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7691_RS05705	COG2217	Heavy metal translocating P-type atpase
H7691_RS05725	COG2010	Cytochrome c
H7691_RS05740	COG3278	Belongs to the heme-copper respiratory oxidase family
H7691_RS05745	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H7691_RS05750	COG1024	Enoyl-CoA hydratase
H7691_RS05750	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7691_RS05765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7691_RS05770	COG0481	GTPase activity
H7691_RS05775	COG0681	Belongs to the peptidase S26 family
H7691_RS05790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7691_RS05805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7691_RS05810	COG2954	triphosphatase activity
H7691_RS05815	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7691_RS05820	COG1472	Belongs to the glycosyl hydrolase 3 family
H7691_RS05825	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7691_RS05830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7691_RS05835	COG1278	Cold shock
H7691_RS05840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7691_RS05845	COG1960	acyl-CoA dehydrogenase activity
H7691_RS05860	COG0183	Belongs to the thiolase family
H7691_RS05875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7691_RS05875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H7691_RS05875	COG1703	isobutyryl-CoA mutase activity
H7691_RS05880	COG5001	Diguanylate cyclase
H7691_RS05880	COG3300	MHYT domain
H7691_RS05890	COG1228	amidohydrolase
H7691_RS05915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7691_RS05920	COG5002	protein histidine kinase activity
H7691_RS05920	COG5001	Diguanylate cyclase
H7691_RS05920	COG3447	MASE1 domain protein
H7691_RS05925	COG0204	Acyl-transferase
H7691_RS05950	COG2814	Major facilitator Superfamily
H7691_RS05965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7691_RS05970	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7691_RS05990	COG1451	nucleotide metabolic process
H7691_RS06000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7691_RS06035	COG2824	Alkylphosphonate utilization operon protein PhnA
H7691_RS06065	COG0392	lysyltransferase activity
H7691_RS06065	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7691_RS06075	COG0251	oxidation-reduction process
H7691_RS06085	COG2733	membrane
H7691_RS06100	COG3759	membrane
H7691_RS06110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7691_RS06120	COG0477	Major facilitator Superfamily
H7691_RS06125	COG2703	oxygen carrier activity
H7691_RS06135	COG0745	RESPONSE REGULATOR receiver
H7691_RS06165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7691_RS06175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7691_RS06180	COG3842	ATPase activity
H7691_RS06185	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7691_RS06190	COG1177	transmembrane transport
H7691_RS06195	COG1012	belongs to the aldehyde dehydrogenase family
H7691_RS06215	COG4535	Mg2 and Co2 transporter CorC
H7691_RS06230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7691_RS06235	COG1702	phosphate starvation-inducible protein PhoH
H7691_RS06240	COG1309	transcriptional regulator
H7691_RS06250	COG1131	(ABC) transporter
H7691_RS06255	COG1129	ABC transporter
H7691_RS06255	COG0842	Transport permease protein
H7691_RS06260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7691_RS06265	COG0741	lytic transglycosylase activity
H7691_RS06270	COG0723	plastoquinol--plastocyanin reductase activity
H7691_RS06275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7691_RS06280	COG2857	Cytochrome c1
H7691_RS06285	COG0625	glutathione transferase activity
H7691_RS06290	COG2969	positive regulation of protein catabolic process
H7691_RS06330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7691_RS06335	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS06340	COG2095	MarC family integral membrane protein
H7691_RS06350	COG1611	Belongs to the LOG family
H7691_RS06355	COG3275	phosphorelay sensor kinase activity
H7691_RS06400	COG0556	nucleotide-excision repair
H7691_RS06410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7691_RS06415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7691_RS06430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7691_RS06695	COG0740	serine-type endopeptidase activity
H7691_RS06755	COG5449	Phage conserved hypothetical protein BR0599
H7691_RS06780	COG0348	domain, Protein
H7691_RS06835	COG3451	type IV secretory pathway VirB4
H7691_RS06845	COG3838	Conjugal transfer protein Trbc
H7691_RS06850	COG4962	Type ii secretion system protein e
H7691_RS06870	COG0583	DNA-binding transcription factor activity
H7691_RS06880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H7691_RS06885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H7691_RS06900	COG2205	protein histidine kinase activity
H7691_RS06905	COG0745	RESPONSE REGULATOR receiver
H7691_RS06915	COG4959	Type IV secretory pathway protease TraF
H7691_RS06930	COG1192	Involved in chromosome partitioning
H7691_RS06965	COG5489	Protein of unknown function (DUF736)
H7691_RS06980	COG1475	DNA binding
H7691_RS06995	COG2003	Belongs to the UPF0758 family
H7691_RS07000	COG4804	nuclease activity
H7691_RS07010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H7691_RS07015	COG0069	glutamate synthase activity
H7691_RS07020	COG0493	'glutamate synthase
H7691_RS07040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7691_RS07050	COG1253	flavin adenine dinucleotide binding
H7691_RS07060	COG0306	phosphate transporter
H7691_RS07080	COG0504	CTP synthase activity
H7691_RS07085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7691_RS07095	COG0148	phosphopyruvate hydratase activity
H7691_RS07100	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7691_RS07105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7691_RS07110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7691_RS07115	COG0585	pseudouridine synthase activity
H7691_RS07120	COG2840	Smr protein MutS2
H7691_RS07125	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7691_RS07135	COG1238	metal cluster binding
H7691_RS07155	COG1534	Rna-binding protein
H7691_RS07160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7691_RS07165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7691_RS07175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7691_RS07180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7691_RS07190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7691_RS07210	COG0688	phosphatidylethanolamine metabolic process
H7691_RS07220	COG2890	protein-(glutamine-N5) methyltransferase activity
H7691_RS07225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7691_RS07230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7691_RS07235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7691_RS07250	COG0101	tRNA pseudouridine synthase activity
H7691_RS07255	COG0135	phosphoribosylanthranilate isomerase activity
H7691_RS07265	COG0133	tryptophan synthase activity
H7691_RS07275	COG0159	tryptophan synthase activity
H7691_RS07280	COG2755	lipolytic protein G-D-S-L family
H7691_RS07280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7691_RS07285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7691_RS07290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7691_RS07295	COG0726	polysaccharide deacetylase
H7691_RS07310	COG0149	triose-phosphate isomerase activity
H7691_RS07325	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7691_RS07330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7691_RS07335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7691_RS07340	COG0649	NAD binding
H7691_RS07345	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H7691_RS07390	COG1007	ATP synthesis coupled electron transport
H7691_RS07400	COG0779	Required for maturation of 30S ribosomal subunits
H7691_RS07405	COG0195	Participates in both transcription termination and antitermination
H7691_RS07410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7691_RS07415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7691_RS07425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7691_RS07445	COG0848	biopolymer transport protein
H7691_RS07455	COG1663	tetraacyldisaccharide 4'-kinase activity
H7691_RS07460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7691_RS07465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7691_RS07475	COG0322	excinuclease ABC activity
H7691_RS07490	COG0582	viral genome integration into host DNA
H7691_RS07505	COG0583	DNA-binding transcription factor activity
H7691_RS07540	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7691_RS07570	COG3842	ATPase activity
H7691_RS07830	COG2814	Major facilitator Superfamily
H7691_RS07835	COG1104	cysteine desulfurase activity
H7691_RS07840	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7691_RS07880	COG0270	DNA (cytosine-5-)-methyltransferase activity
H7691_RS07885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7691_RS07890	COG0629	single-stranded DNA binding
H7691_RS07950	COG0582	viral genome integration into host DNA
H7691_RS07965	COG0583	DNA-binding transcription factor activity
H7691_RS08010	COG0501	Belongs to the peptidase M48B family
H7691_RS08030	COG0672	)-iron permease
H7691_RS08040	COG2217	Heavy metal translocating P-type atpase
H7691_RS08045	COG2814	Major facilitator Superfamily
H7691_RS08050	COG1937	Protein conserved in bacteria
H7691_RS08100	COG2003	Belongs to the UPF0758 family
H7691_RS08160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7691_RS08165	COG1196	nuclear chromosome segregation
H7691_RS08175	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H7691_RS08320	COG0629	single-stranded DNA binding
H7691_RS08405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7691_RS08415	COG1960	acyl-CoA dehydrogenase activity
H7691_RS08435	COG3712	iron ion homeostasis
H7691_RS08440	COG1228	amidohydrolase
H7691_RS08445	COG1473	amidohydrolase
H7691_RS08450	COG3040	lipid binding
H7691_RS08515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7691_RS08525	COG1570	exodeoxyribonuclease VII activity
H7691_RS08530	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7691_RS08535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7691_RS08535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7691_RS08540	COG0802	atpase or kinase
H7691_RS08545	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7691_RS08550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7691_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS08575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7691_RS08580	COG0501	Belongs to the peptidase M48B family
H7691_RS08605	COG5001	Diguanylate cyclase
H7691_RS08605	COG3300	MHYT domain
H7691_RS08610	COG1509	lysine 2,3-aminomutase activity
H7691_RS08615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7691_RS08620	COG3548	integral membrane protein
H7691_RS08625	COG0402	S-adenosylhomocysteine deaminase activity
H7691_RS08630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7691_RS08665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7691_RS08685	COG2166	iron-sulfur cluster assembly
H7691_RS08700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7691_RS08705	COG0137	argininosuccinate synthase activity
H7691_RS08710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7691_RS08715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7691_RS08730	COG0165	Argininosuccinate lyase
H7691_RS08770	COG1294	oxidase, subunit
H7691_RS08780	COG4988	ABC transporter
H7691_RS08785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7691_RS08790	COG1793	dna ligase
H7691_RS08795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7691_RS08805	COG4235	cytochrome complex assembly
H7691_RS08810	COG3088	subunit of a heme lyase
H7691_RS08815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7691_RS08825	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7691_RS08855	COG0436	Aminotransferase
H7691_RS08875	COG1187	pseudouridine synthase activity
H7691_RS08880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7691_RS08885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7691_RS08890	COG2350	Protein conserved in bacteria
H7691_RS08925	COG0395	ABC-type sugar transport system, permease component
H7691_RS08940	COG0800	Aldolase
H7691_RS08945	COG0129	dihydroxy-acid dehydratase activity
H7691_RS08955	COG0837	glucose binding
H7691_RS08960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7691_RS08985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7691_RS09010	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7691_RS09025	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7691_RS09030	COG1194	a g-specific adenine glycosylase
H7691_RS09035	COG0552	protein localization to endoplasmic reticulum
H7691_RS09045	COG0326	Molecular chaperone. Has ATPase activity
H7691_RS09050	COG0742	ribosomal rna small subunit methyltransferase
H7691_RS09055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7691_RS09065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7691_RS09070	COG0405	Gamma-glutamyltransferase
H7691_RS09080	COG3135	benzoate transporter
H7691_RS09090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7691_RS09095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7691_RS09110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7691_RS09135	COG0583	DNA-binding transcription factor activity
H7691_RS09165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7691_RS09170	COG1522	sequence-specific DNA binding
H7691_RS09175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7691_RS09180	COG0343	queuine tRNA-ribosyltransferase activity
H7691_RS09185	COG1862	Preprotein translocase
H7691_RS09195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7691_RS09200	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7691_RS09205	COG2200	EAL domain
H7691_RS09210	COG2081	HI0933 family
H7691_RS09225	COG1278	Cold shock
H7691_RS09230	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7691_RS09235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7691_RS09240	COG0513	Belongs to the DEAD box helicase family
H7691_RS09250	COG0583	DNA-binding transcription factor activity
H7691_RS09255	COG0488	(ABC) transporter
H7691_RS09275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7691_RS09285	COG3104	oligopeptide transport
H7691_RS09310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7691_RS09315	COG0339	signal peptide processing
H7691_RS09320	COG0386	Belongs to the glutathione peroxidase family
H7691_RS09345	COG2860	membrane
H7691_RS09370	COG1393	Belongs to the ArsC family
H7691_RS09400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7691_RS09405	COG0084	hydrolase, TatD family'
H7691_RS09440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7691_RS09445	COG1183	phosphatidylcholine synthase activity
H7691_RS09455	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7691_RS09475	COG2183	response to ionizing radiation
H7691_RS09525	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS09530	COG1335	isochorismatase
H7691_RS09550	COG2823	Periplasmic or secreted lipoprotein
H7691_RS09590	COG1064	alcohol dehydrogenase
H7691_RS09595	COG1473	amidohydrolase
H7691_RS09600	COG1595	DNA-templated transcription, initiation
H7691_RS09605	COG4944	Protein of unknown function (DUF1109)
H7691_RS09645	COG4644	lycopene metabolic process
H7691_RS09655	COG3142	Participates in the control of copper homeostasis
H7691_RS09660	COG1446	asparaginase
H7691_RS09665	COG0837	glucose binding
H7691_RS09670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7691_RS09675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7691_RS09680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7691_RS09685	COG1674	ftsk spoiiie
H7691_RS09690	COG0492	ferredoxin-NADP+ reductase activity
H7691_RS09695	COG1408	metallophosphoesterase
H7691_RS09725	COG0542	response to heat
H7691_RS09745	COG0482	sulfurtransferase activity
H7691_RS09750	COG2915	High frequency lysogenization protein hflD homolog
H7691_RS09780	COG5002	protein histidine kinase activity
H7691_RS09800	COG0784	Response regulator, receiver
H7691_RS09800	COG0835	chemotaxis
H7691_RS09815	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7691_RS09820	COG1749	Flagellar hook protein flgE
H7691_RS09825	COG4787	bacterial-type flagellum-dependent cell motility
H7691_RS09835	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7691_RS09900	COG2201	protein-glutamate methylesterase activity
H7691_RS09920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7691_RS09945	COG0438	transferase activity, transferring glycosyl groups
H7691_RS09945	COG1216	Glycosyl transferase, family 2
H7691_RS09950	COG1677	Flagellar hook-basal body complex protein FliE
H7691_RS09955	COG1766	The M ring may be actively involved in energy transduction
H7691_RS09960	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7691_RS10000	COG3190	flagellar
H7691_RS10005	COG1338	Plays a role in the flagellum-specific transport system
H7691_RS10060	COG0643	Histidine kinase
H7691_RS10060	COG2198	Histidine kinase
H7691_RS10060	COG0784	Response regulator, receiver
H7691_RS10065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7691_RS10080	COG0835	chemotaxis
H7691_RS10090	COG0745	RESPONSE REGULATOR receiver
H7691_RS10105	COG0840	transmembrane signaling receptor activity
H7691_RS10110	COG0840	transmembrane signaling receptor activity
H7691_RS10110	COG0840	transmembrane signaling receptor activity
H7691_RS10115	COG0840	transmembrane signaling receptor activity
H7691_RS10125	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H7691_RS10130	COG0835	chemotaxis
H7691_RS10140	COG0840	transmembrane signaling receptor activity
H7691_RS10145	COG0840	transmembrane signaling receptor activity
H7691_RS10145	COG0840	transmembrane signaling receptor activity
H7691_RS10190	COG1228	amidohydrolase
H7691_RS10245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7691_RS10245	COG1017	nitric oxide dioxygenase activity
H7691_RS10260	COG2885	chlorophyll binding
H7691_RS10260	COG3047	cAMP biosynthetic process
H7691_RS10270	COG0318	PFAM AMP-dependent synthetase and ligase
H7691_RS10275	COG1024	Enoyl-CoA hydratase
H7691_RS10280	COG2198	Histidine kinase
H7691_RS10280	COG0784	Response regulator, receiver
H7691_RS10280	COG2205	protein histidine kinase activity
H7691_RS10290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7691_RS10310	COG3279	Response regulator of the LytR AlgR family
H7691_RS10320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7691_RS10330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7691_RS10335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7691_RS10340	COG0505	Belongs to the CarA family
H7691_RS10345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7691_RS10350	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7691_RS10360	COG1918	ferrous iron import across plasma membrane
H7691_RS10360	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H7691_RS10390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7691_RS10410	COG0277	FAD linked oxidase domain protein
H7691_RS10415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7691_RS10425	COG0531	amino acid
H7691_RS10430	COG0531	amino acid
H7691_RS10435	COG0235	Class ii aldolase
H7691_RS10440	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H7691_RS10445	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H7691_RS10450	COG1285	pathogenesis
H7691_RS10465	COG0531	amino acid
H7691_RS10475	COG3485	protocatechuate 3,4-dioxygenase
H7691_RS10500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7691_RS10500	COG0140	phosphoribosyl-ATP diphosphatase activity
H7691_RS10510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7691_RS10515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7691_RS10520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7691_RS10520	COG0131	Imidazoleglycerol-phosphate dehydratase
H7691_RS10525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7691_RS10530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7691_RS10535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7691_RS10545	COG0124	histidyl-tRNA synthetase
H7691_RS10550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7691_RS10560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7691_RS10565	COG0083	homoserine kinase activity
H7691_RS10590	COG1012	belongs to the aldehyde dehydrogenase family
H7691_RS10605	COG0167	dihydroorotate dehydrogenase activity
H7691_RS10610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7691_RS10640	COG0024	Methionine aminopeptidase
H7691_RS10650	COG2003	Belongs to the UPF0758 family
H7691_RS10675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7691_RS10695	COG0084	hydrolase, TatD family'
H7691_RS10720	COG0582	viral genome integration into host DNA
H7691_RS10725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7691_RS10725	COG0519	Catalyzes the synthesis of GMP from XMP
H7691_RS10740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7691_RS10745	COG1160	GTP binding
H7691_RS10750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7691_RS10760	COG1426	Protein conserved in bacteria
H7691_RS10770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7691_RS10775	COG0105	UTP biosynthetic process
H7691_RS10785	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7691_RS10785	COG1024	Enoyl-CoA hydratase
H7691_RS10790	COG0183	Belongs to the thiolase family
H7691_RS10810	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7691_RS10820	COG0776	regulation of translation
H7691_RS10830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7691_RS10835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7691_RS10845	COG2957	Belongs to the agmatine deiminase family
H7691_RS10850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7691_RS10875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7691_RS10905	COG0316	Belongs to the HesB IscA family
H7691_RS10905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7691_RS10910	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7691_RS10925	COG1530	ribonuclease E activity
H7691_RS10935	COG0671	phosphoesterase, PA-phosphatase related
H7691_RS10940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7691_RS10950	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H7691_RS10955	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS10985	COG0305	Participates in initiation and elongation during chromosome replication
H7691_RS10995	COG0367	asparagine synthase
H7691_RS11000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7691_RS11005	COG0625	glutathione transferase activity
H7691_RS11020	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7691_RS11040	COG0583	DNA-binding transcription factor activity
H7691_RS11045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7691_RS11060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7691_RS11065	COG1605	Chorismate mutase
H7691_RS11065	COG0077	Prephenate dehydratase
H7691_RS11070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7691_RS11115	COG0166	Belongs to the GPI family
H7691_RS11120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H7691_RS11125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7691_RS11130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7691_RS11140	COG0617	tRNA 3'-terminal CCA addition
H7691_RS11150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7691_RS11160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7691_RS11170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7691_RS11175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7691_RS11195	COG0352	thiamine-phosphate diphosphorylase activity
H7691_RS11195	COG0351	phosphomethylpyrimidine kinase
H7691_RS11240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7691_RS11260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7691_RS11265	COG0360	Binds together with S18 to 16S ribosomal RNA
H7691_RS11270	COG0316	Belongs to the HesB IscA family
H7691_RS11275	COG0017	Asparaginyl-tRNA synthetase
H7691_RS11290	COG2808	Putative FMN-binding domain
H7691_RS11295	COG0288	reversible hydration of carbon dioxide
H7691_RS11305	COG3844	kynureninase activity
H7691_RS11310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7691_RS11315	COG2925	Exonuclease
H7691_RS11350	COG1278	Cold shock
H7691_RS11370	COG2902	Dehydrogenase
H7691_RS11380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7691_RS11385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7691_RS11405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7691_RS11410	COG1960	acyl-CoA dehydrogenase activity
H7691_RS11415	COG2226	methyltransferase
H7691_RS11435	COG0583	DNA-binding transcription factor activity
H7691_RS11440	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7691_RS11445	COG2814	Major facilitator Superfamily
H7691_RS11455	COG2900	Belongs to the SlyX family
H7691_RS11470	COG0386	Belongs to the glutathione peroxidase family
H7691_RS11480	COG1725	Transcriptional regulator
H7691_RS11485	COG1131	(ABC) transporter
H7691_RS11520	COG0840	transmembrane signaling receptor activity
H7691_RS11535	COG2850	peptidyl-arginine hydroxylation
H7691_RS11545	COG0567	Dehydrogenase, E1 component
H7691_RS11555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7691_RS11570	COG1595	DNA-templated transcription, initiation
H7691_RS11585	COG1132	(ABC) transporter
H7691_RS11600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7691_RS11605	COG0484	heat shock protein binding
H7691_RS11610	COG0443	Heat shock 70 kDa protein
H7691_RS11615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7691_RS11620	COG0497	DNA recombination
H7691_RS11630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7691_RS11645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7691_RS11670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7691_RS11675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7691_RS11690	COG0583	DNA-binding transcription factor activity
H7691_RS11695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7691_RS11710	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7691_RS11740	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7691_RS11910	COG1475	DNA binding
H7691_RS11935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7691_RS12005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7691_RS12220	COG1475	DNA binding
H7691_RS12340	COG0582	viral genome integration into host DNA
H7691_RS12385	COG3772	lysozyme
H7691_RS12525	COG0305	Participates in initiation and elongation during chromosome replication
H7691_RS12555	COG4197	protein conserved in bacteria, prophage-related
H7691_RS12655	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7691_RS12660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7691_RS12665	COG2137	regulation of response to DNA damage stimulus
H7691_RS12670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7691_RS12680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7691_RS12685	COG1546	Belongs to the CinA family
H7691_RS12695	COG0433	COG0433 Predicted ATPase
H7691_RS12700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7691_RS12710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7691_RS12715	COG0412	Dienelactone hydrolase
H7691_RS12730	COG0717	Belongs to the dCTP deaminase family
H7691_RS12735	COG0489	protein tyrosine kinase activity
H7691_RS12740	COG4771	TonB-dependent receptor
H7691_RS12745	COG0457	Tetratricopeptide repeat
H7691_RS12755	COG3590	peptidase
H7691_RS12775	COG0697	spore germination
H7691_RS12785	COG2311	Membrane
H7691_RS12790	COG1047	Peptidyl-prolyl cis-trans
H7691_RS12795	COG0791	NLP P60 protein
H7691_RS12800	COG0791	NLP P60 protein
H7691_RS12805	COG0612	Peptidase, M16
H7691_RS12810	COG0612	Peptidase, M16
H7691_RS12815	COG1301	dicarboxylic acid transport
H7691_RS12825	COG0037	tRNA processing
H7691_RS12830	COG1722	exodeoxyribonuclease VII activity
H7691_RS12835	COG0142	geranyltranstransferase activity
H7691_RS12845	COG0312	modulator of DNA gyrase
H7691_RS12850	COG3028	Belongs to the UPF0307 family
H7691_RS12865	COG0312	modulator of DNA gyrase
H7691_RS12880	COG0424	maF-like protein
H7691_RS12885	COG2968	Membrane
H7691_RS12905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7691_RS12915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7691_RS12930	COG0495	leucyl-tRNA aminoacylation
H7691_RS12965	COG2203	Gaf domain
H7691_RS12965	COG3706	GGDEF domain
H7691_RS12965	COG4251	negative regulation of phosphorylation
H7691_RS12965	COG5001	Diguanylate cyclase
H7691_RS12990	COG0346	lactoylglutathione lyase activity
H7691_RS12995	COG1131	(ABC) transporter
H7691_RS13010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7691_RS13010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7691_RS13035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7691_RS13035	COG0116	Belongs to the methyltransferase superfamily
H7691_RS13055	COG0494	nUDIX hydrolase
H7691_RS13065	COG1024	Enoyl-CoA hydratase
H7691_RS13075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7691_RS13100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7691_RS13105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7691_RS13110	COG0573	inorganic phosphate transmembrane transporter activity
H7691_RS13115	COG0581	inorganic phosphate transmembrane transporter activity
H7691_RS13125	COG0704	Plays a role in the regulation of phosphate uptake
H7691_RS13130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7691_RS13135	COG0557	exoribonuclease II activity
H7691_RS13155	COG2814	Major facilitator Superfamily
H7691_RS13160	COG1566	PFAM secretion protein HlyD family protein
H7691_RS13205	COG0367	asparagine synthase
H7691_RS13210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7691_RS13215	COG1393	Belongs to the ArsC family
H7691_RS13225	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7691_RS13230	COG0024	Methionine aminopeptidase
H7691_RS13235	COG0052	Belongs to the universal ribosomal protein uS2 family
H7691_RS13240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7691_RS13250	COG0528	UMP kinase activity
H7691_RS13255	COG0233	cytoplasmic translational termination
H7691_RS13265	COG0575	Belongs to the CDS family
H7691_RS13270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7691_RS13275	COG0750	zinc metalloprotease
H7691_RS13280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7691_RS13285	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7691_RS13295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7691_RS13315	COG0825	malonyl-CoA metabolic process
H7691_RS13320	COG1981	membrane
H7691_RS13385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7691_RS13430	COG1132	(ABC) transporter
H7691_RS13440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7691_RS13465	COG1187	pseudouridine synthase activity
H7691_RS13550	COG0735	belongs to the Fur family
H7691_RS13555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7691_RS13565	COG1024	Enoyl-CoA hydratase
H7691_RS13565	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7691_RS13570	COG1946	Acyl-CoA thioesterase
H7691_RS13580	COG1595	DNA-templated transcription, initiation
H7691_RS13590	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7691_RS13600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7691_RS13625	COG1073	alpha beta
H7691_RS13640	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H7691_RS13655	COG2197	response regulator
H7691_RS13660	COG4585	Histidine kinase
H7691_RS13670	COG0850	regulation of cytokinetic process
H7691_RS13675	COG2894	cell division
H7691_RS13680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7691_RS13690	COG2205	protein histidine kinase activity
H7691_RS13700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7691_RS13710	COG2194	sulfuric ester hydrolase activity
H7691_RS13740	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H7691_RS13770	COG2814	Major facilitator Superfamily
H7691_RS13775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7691_RS13775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7691_RS13790	COG1917	Cupin 2, conserved barrel domain protein
H7691_RS13790	COG2207	Transcriptional regulator
H7691_RS13805	COG1846	Transcriptional regulator
H7691_RS13835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7691_RS13845	COG0330	HflC and HflK could
H7691_RS13850	COG0330	HflC and HflK could
H7691_RS13855	COG0604	alcohol dehydrogenase
H7691_RS13875	COG0678	peroxiredoxin activity
H7691_RS13885	COG4953	penicillin-binding protein 1C
H7691_RS13890	COG2373	Large extracellular alpha-helical protein
H7691_RS13920	COG0372	Belongs to the citrate synthase family
H7691_RS13955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7691_RS13975	COG2814	Major facilitator Superfamily
H7691_RS13990	COG3038	cytochrome b561
H7691_RS14010	COG1760	l-serine dehydratase
H7691_RS14025	COG0527	aspartate kinase activity
H7691_RS14025	COG0460	homoserine dehydrogenase
H7691_RS14030	COG0626	cystathionine gamma-synthase activity
H7691_RS14035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7691_RS14040	COG0739	heme binding
H7691_RS14045	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H7691_RS14050	COG1272	protein, Hemolysin III
H7691_RS14055	COG2982	Protein involved in outer membrane biogenesis
H7691_RS14060	COG3620	sequence-specific DNA binding
H7691_RS14060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7691_RS14060	COG0617	tRNA 3'-terminal CCA addition
H7691_RS14065	COG0463	Glycosyl transferase, family 2
H7691_RS14070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7691_RS14075	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7691_RS14100	COG1960	acyl-CoA dehydrogenase activity
H7691_RS14145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7691_RS14155	COG0330	HflC and HflK could
H7691_RS14165	COG1742	UPF0060 membrane protein
H7691_RS14170	COG3956	TIGRFAM MazG family protein
H7691_RS14175	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7691_RS14180	COG0494	nUDIX hydrolase
H7691_RS14185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7691_RS14205	COG0840	transmembrane signaling receptor activity
H7691_RS14210	COG0835	chemotaxis
H7691_RS14225	COG0189	ligase activity
H7691_RS14255	COG1764	response to oxidative stress
H7691_RS14280	COG1959	2 iron, 2 sulfur cluster binding
H7691_RS14285	COG0719	Fe-S assembly protein
H7691_RS14295	COG0396	ATPase activity
H7691_RS14300	COG0719	Fe-S assembly protein
H7691_RS14305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7691_RS14315	COG2146	nitrite reductase [NAD(P)H] activity
H7691_RS14320	COG4774	siderophore transport
H7691_RS14330	COG3128	pkhd-type hydroxylase
H7691_RS14340	COG4771	TonB-dependent receptor
H7691_RS14360	COG1477	protein flavinylation
H7691_RS14365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7691_RS14385	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS14415	COG0640	Transcriptional regulator
H7691_RS14430	COG2205	protein histidine kinase activity
H7691_RS14435	COG4771	TonB-dependent receptor
H7691_RS14440	COG2610	gluconate transmembrane transporter activity
H7691_RS14445	COG1555	photosystem II stabilization
H7691_RS14460	COG3178	'Phosphotransferase
H7691_RS14465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7691_RS14470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7691_RS14475	COG0628	permease
H7691_RS14485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7691_RS14500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7691_RS14520	COG0045	succinate-CoA ligase (ADP-forming) activity
H7691_RS14535	COG4191	Histidine kinase
H7691_RS14540	COG5001	Diguanylate cyclase
H7691_RS14565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7691_RS14610	COG1459	type II secretion system
H7691_RS14615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7691_RS14630	COG0745	RESPONSE REGULATOR receiver
H7691_RS14640	COG0189	ligase activity
H7691_RS14660	COG2022	thiamine diphosphate biosynthetic process
H7691_RS14670	COG3273	potassium ion transport
H7691_RS14670	COG0471	metal ion transport
H7691_RS14700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7691_RS14700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7691_RS14705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7691_RS14710	COG1115	amino acid carrier protein
H7691_RS14720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7691_RS14725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7691_RS14730	COG2895	sulfate adenylyltransferase (ATP) activity
H7691_RS14730	COG0529	Catalyzes the synthesis of activated sulfate
H7691_RS14740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7691_RS14745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7691_RS14750	COG0175	sulfate reduction
H7691_RS14770	COG0583	DNA-binding transcription factor activity
H7691_RS14785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H7691_RS14790	COG3588	fructose-bisphosphate aldolase
H7691_RS14795	COG0469	pyruvate kinase activity
H7691_RS14805	COG0126	phosphoglycerate kinase activity
H7691_RS14810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7691_RS14825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7691_RS14855	COG0427	acetyl-CoA hydrolase
H7691_RS14870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7691_RS14875	COG1301	dicarboxylic acid transport
H7691_RS14905	COG0714	Associated with various cellular activities
H7691_RS14950	COG0254	rRNA binding
H7691_RS14960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7691_RS14970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7691_RS14975	COG1758	RNA polymerase activity
H7691_RS14990	COG1561	YicC-like family, N-terminal region
H7691_RS14995	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7691_RS15000	COG0346	lactoylglutathione lyase activity
H7691_RS15010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7691_RS15025	COG0006	proline dipeptidase activity
H7691_RS15030	COG0006	proline dipeptidase activity
H7691_RS15035	COG3079	Belongs to the UPF0149 family
H7691_RS15055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7691_RS15090	COG2912	Transglutaminase-like superfamily
H7691_RS15100	COG0352	thiamine-phosphate diphosphorylase activity
H7691_RS15110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7691_RS15120	COG0537	adenosine 5'-monophosphoramidase activity
H7691_RS15125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7691_RS15130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7691_RS15135	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS15150	COG0671	phosphoesterase, PA-phosphatase related
H7691_RS15160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7691_RS15165	COG0563	adenylate kinase activity
H7691_RS15190	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H7691_RS15195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7691_RS15220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7691_RS15225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7691_RS15230	COG0405	Gamma-glutamyltransferase
H7691_RS15275	COG3409	Peptidoglycan-binding domain 1 protein
H7691_RS15275	COG3267	Type II secretory pathway component ExeA
H7691_RS15320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7691_RS15340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7691_RS15355	COG0473	3-isopropylmalate dehydrogenase activity
H7691_RS15360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7691_RS15385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7691_RS15415	COG3634	alkyl hydroperoxide reductase activity
H7691_RS15420	COG0583	DNA-binding transcription factor activity
H7691_RS15425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7691_RS15440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7691_RS15455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7691_RS15465	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7691_RS15485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7691_RS15490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7691_RS15495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7691_RS15505	COG2096	Adenosyltransferase
H7691_RS15515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7691_RS15520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7691_RS15525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7691_RS15530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7691_RS15535	COG2967	ApaG domain
H7691_RS15540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7691_RS15555	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7691_RS15560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7691_RS15580	COG0861	Integral membrane protein TerC family
H7691_RS15585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7691_RS15590	COG0642	Histidine kinase
H7691_RS15610	COG4771	TonB-dependent receptor
H7691_RS15620	COG0667	Aldo Keto reductase
H7691_RS15625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7691_RS15635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7691_RS15660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7691_RS15680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7691_RS15685	COG1607	acyl-coa hydrolase
H7691_RS15690	COG2815	serine threonine protein kinase
H7691_RS15690	COG0515	serine threonine protein kinase
H7691_RS15695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7691_RS15705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7691_RS15715	COG0456	acetyltransferase
H7691_RS15730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7691_RS15740	COG0494	nUDIX hydrolase
H7691_RS15745	COG0653	protein targeting
H7691_RS15750	COG0739	heme binding
H7691_RS15760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7691_RS15765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7691_RS15775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7691_RS15800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7691_RS15815	COG3116	cell division
H7691_RS15820	COG0275	rRNA processing
H7691_RS15825	COG2001	Belongs to the MraZ family
H7691_RS15850	COG0792	nuclease activity
H7691_RS15855	COG1988	membrane-bound metal-dependent
H7691_RS15860	COG0277	FAD linked oxidase domain protein
H7691_RS15870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7691_RS15875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7691_RS15890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7691_RS15890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7691_RS15900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7691_RS15905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7691_RS15915	COG0488	(ABC) transporter
H7691_RS15920	COG2252	PERMEase
H7691_RS15930	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7691_RS15935	COG0457	Tetratricopeptide repeat
H7691_RS15935	COG3118	belongs to the thioredoxin family
H7691_RS15940	COG1215	transferase activity, transferring glycosyl groups
H7691_RS15945	COG1215	transferase activity, transferring glycosyl groups
H7691_RS15960	COG2194	sulfuric ester hydrolase activity
H7691_RS15975	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7691_RS15980	COG0457	Tetratricopeptide repeat
H7691_RS15985	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7691_RS15990	COG1215	transferase activity, transferring glycosyl groups
H7691_RS15995	COG1215	transferase activity, transferring glycosyl groups
H7691_RS16020	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7691_RS16020	COG0047	phosphoribosylformylglycinamidine synthase activity
H7691_RS16030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7691_RS16035	COG4974	Belongs to the 'phage' integrase family
H7691_RS16045	COG0795	lipopolysaccharide-transporting ATPase activity
H7691_RS16055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7691_RS16070	COG0525	valine-tRNA ligase activity
H7691_RS16080	COG0456	acetyltransferase
H7691_RS16090	COG1183	phosphatidylcholine synthase activity
H7691_RS16100	COG0442	prolyl-tRNA aminoacylation
H7691_RS16115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7691_RS16120	COG1127	ABC transporter
H7691_RS16125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7691_RS16125	COG3218	ABC-type transport auxiliary lipoprotein component
H7691_RS16140	COG0024	Methionine aminopeptidase
H7691_RS16155	COG3214	Protein conserved in bacteria
H7691_RS16180	COG1506	peptidase
H7691_RS16180	COG0823	Involved in the tonB-independent uptake of proteins
H7691_RS16185	COG4206	TonB-dependent receptor
H7691_RS16220	COG2375	cellular response to nickel ion
H7691_RS16265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7691_RS16300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7691_RS16310	COG0459	protein refolding
H7691_RS16315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7691_RS16320	COG1324	tolerance protein
H7691_RS16330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7691_RS16335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7691_RS16340	COG0511	ligase activity, forming carbon-carbon bonds
H7691_RS16345	COG0439	Biotin carboxylase
H7691_RS16350	COG2264	protein methyltransferase activity
H7691_RS16360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7691_RS16365	COG0138	bifunctional purine biosynthesis protein purh
H7691_RS16380	COG0151	Belongs to the GarS family
H7691_RS16385	COG0667	Aldo Keto reductase
H7691_RS16395	COG1289	transmembrane transporter activity
H7691_RS16400	COG2814	Major facilitator Superfamily
H7691_RS16410	COG2814	Major facilitator Superfamily
H7691_RS16465	COG0784	Response regulator, receiver
H7691_RS16465	COG2205	protein histidine kinase activity
H7691_RS16465	COG5002	protein histidine kinase activity
H7691_RS16480	COG1051	belongs to the nudix hydrolase family
H7691_RS16500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7691_RS16505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7691_RS16510	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H7691_RS16520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H7691_RS16525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7691_RS16530	COG0730	response to heat
H7691_RS16540	COG0134	indole-3-glycerol-phosphate synthase activity
H7691_RS16545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7691_RS16570	COG2205	protein histidine kinase activity
H7691_RS16595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7691_RS16600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7691_RS16605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7691_RS16620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7691_RS16620	COG2111	Na H antiporter
H7691_RS16625	COG1006	Multisubunit Na H antiporter MnhC subunit
H7691_RS16630	COG0651	ATP synthesis coupled electron transport
H7691_RS16640	COG2212	antiporter activity
H7691_RS16645	COG1320	monovalent cation:proton antiporter activity
H7691_RS16680	COG3104	oligopeptide transport
H7691_RS16685	COG3483	tryptophan 2,3-dioxygenase activity
H7691_RS16690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7691_RS16705	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7691_RS16730	COG0702	epimerase
H7691_RS16735	COG3706	GGDEF domain
H7691_RS16740	COG0612	Peptidase, M16
H7691_RS16755	COG2354	Protein conserved in bacteria
H7691_RS16760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7691_RS16765	COG1368	sulfuric ester hydrolase activity
H7691_RS16770	COG3264	Mechanosensitive ion channel
H7691_RS16770	COG1196	nuclear chromosome segregation
H7691_RS16785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7691_RS16800	COG4807	Protein conserved in bacteria
H7691_RS16810	COG0789	Transcriptional regulator
H7691_RS16860	COG0596	Alpha beta hydrolase
H7691_RS16890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7691_RS16910	COG0628	permease
H7691_RS16920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7691_RS16925	COG0753	catalase activity
H7691_RS16935	COG2197	response regulator
H7691_RS16940	COG4585	Histidine kinase
H7691_RS16945	COG0842	Transport permease protein
H7691_RS16950	COG1131	(ABC) transporter
H7691_RS16955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7691_RS16960	COG1136	(ABC) transporter
H7691_RS16970	COG0577	efflux transmembrane transporter activity
H7691_RS16970	COG1136	(ABC) transporter
H7691_RS16975	COG4206	TonB-dependent receptor
H7691_RS16985	COG2962	Rard protein
H7691_RS16990	COG0697	spore germination
H7691_RS17010	COG0180	Tryptophanyl-tRNA synthetase
H7691_RS17020	COG3237	CsbD-like
H7691_RS17045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7691_RS17090	COG3038	cytochrome b561
H7691_RS17100	COG2203	Gaf domain
H7691_RS17100	COG3706	GGDEF domain
H7691_RS17100	COG5001	Diguanylate cyclase
H7691_RS17100	COG4251	negative regulation of phosphorylation
H7691_RS17110	COG4774	siderophore transport
H7691_RS17125	COG3655	Transcriptional regulator
H7691_RS17130	COG1506	peptidase
H7691_RS17135	COG0784	Response regulator, receiver
H7691_RS17135	COG2205	protein histidine kinase activity
H7691_RS17145	COG0784	Response regulator, receiver
H7691_RS17145	COG2205	protein histidine kinase activity
H7691_RS17150	COG2197	response regulator
H7691_RS17195	COG0582	viral genome integration into host DNA
H7691_RS17210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H7691_RS17215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H7691_RS17215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H7691_RS17245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7691_RS17260	COG3209	COG3209 Rhs family protein
H7691_RS17270	COG2076	Multidrug Resistance protein
H7691_RS17315	COG1285	pathogenesis
H7691_RS17320	COG1335	isochorismatase
H7691_RS17330	COG1902	pentaerythritol trinitrate reductase activity
H7691_RS17345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7691_RS17365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7691_RS17375	COG0697	spore germination
H7691_RS17400	COG1960	acyl-CoA dehydrogenase activity
H7691_RS17405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7691_RS17440	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7691_RS17445	COG0583	DNA-binding transcription factor activity
H7691_RS17455	COG0277	FAD linked oxidase domain protein
H7691_RS17460	COG1304	FMN binding
H7691_RS17465	COG2186	Transcriptional regulator
H7691_RS17475	COG0681	Belongs to the peptidase S26 family
H7691_RS17490	COG0339	signal peptide processing
H7691_RS17495	COG0415	Belongs to the DNA photolyase family
H7691_RS17545	COG0564	pseudouridine synthase activity
H7691_RS17565	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7691_RS17580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7691_RS17585	COG0318	PFAM AMP-dependent synthetase and ligase
H7691_RS17595	COG0596	Alpha beta hydrolase
H7691_RS17600	COG1573	uracil-dna glycosylase
H7691_RS17605	COG3012	SEC-C Motif Domain Protein
H7691_RS17605	COG3318	Belongs to the UPF0149 family
H7691_RS17610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7691_RS17620	COG0612	Peptidase, M16
H7691_RS17630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7691_RS17640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7691_RS17645	COG1960	acyl-CoA dehydrogenase activity
H7691_RS17650	COG1113	amino acid transport
H7691_RS17660	COG1199	ATP-dependent helicase activity
H7691_RS17670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7691_RS17690	COG3781	membrane
H7691_RS17735	COG3209	COG3209 Rhs family protein
H7691_RS17765	COG0625	glutathione transferase activity
H7691_RS17780	COG1668	transmembrane transport
H7691_RS17785	COG4555	ABC transporter
H7691_RS17820	COG1131	(ABC) transporter
H7691_RS17825	COG0842	Transport permease protein
H7691_RS17830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7691_RS17845	COG0084	hydrolase, TatD family'
H7691_RS17860	COG1187	pseudouridine synthase activity
H7691_RS17870	COG0667	Aldo Keto reductase
H7691_RS17890	COG2239	Acts as a magnesium transporter
H7691_RS17895	COG0475	glutathione-regulated potassium exporter activity
H7691_RS17895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7691_RS17920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7691_RS17930	COG0463	Glycosyl transferase, family 2
H7691_RS17935	COG1028	Short-chain dehydrogenase reductase Sdr
H7691_RS17940	COG2365	Tyrosine phosphatase family
H7691_RS17945	COG4771	TonB-dependent receptor
H7691_RS17975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7691_RS17990	COG0251	oxidation-reduction process
H7691_RS18015	COG0408	coproporphyrinogen oxidase activity
H7691_RS18020	COG2323	membrane
H7691_RS18035	COG0589	response to stress
H7691_RS18040	COG0210	DNA helicase
H7691_RS18050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7691_RS18055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7691_RS18095	COG4771	TonB-dependent receptor
H7691_RS18100	COG1429	ligase activity, forming nitrogen-metal bonds
H7691_RS18120	COG0463	Glycosyl transferase, family 2
H7691_RS18135	COG1475	DNA binding
H7691_RS18140	COG1192	Involved in chromosome partitioning
H7691_RS18145	COG0357	Ribosomal RNA small subunit methyltransferase G
H7691_RS18150	COG2091	lysine biosynthetic process via aminoadipic acid
H7691_RS18165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7691_RS18170	COG4149	molybdate abc transporter
H7691_RS18175	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7691_RS18185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7691_RS18190	COG2181	nitrate reductase activity
H7691_RS18195	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H7691_RS18200	COG1140	nitrate reductase beta subunit
H7691_RS18205	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H7691_RS18210	COG2223	nitrite transmembrane transporter activity
H7691_RS18220	COG0746	molybdenum cofactor guanylyltransferase activity
H7691_RS18225	COG0314	molybdopterin synthase activity
H7691_RS18235	COG0303	'Molybdopterin
H7691_RS18240	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7691_RS18240	COG0315	cyclic pyranopterin monophosphate synthase activity
H7691_RS18245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7691_RS18265	COG4771	TonB-dependent receptor
H7691_RS18275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7691_RS18280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7691_RS18285	COG1120	ATPase activity
H7691_RS18290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7691_RS18300	COG3162	membrane
H7691_RS18320	COG0840	transmembrane signaling receptor activity
H7691_RS18325	COG1971	Probably functions as a manganese efflux pump
H7691_RS18340	COG2199	diguanylate cyclase activity
H7691_RS18385	COG0729	surface antigen
H7691_RS18405	COG0752	glycyl-tRNA synthetase alpha subunit
H7691_RS18410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7691_RS18415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7691_RS18415	COG0519	Catalyzes the synthesis of GMP from XMP
H7691_RS18425	COG0805	protein transport
H7691_RS18445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7691_RS18450	COG2267	carboxylic ester hydrolase activity
H7691_RS18460	COG2974	May be involved in recombination
H7691_RS18465	COG0037	tRNA processing
H7691_RS18490	COG2937	Belongs to the GPAT DAPAT family
H7691_RS18500	COG0284	orotidine-5'-phosphate decarboxylase activity
H7691_RS18505	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H7691_RS18510	COG3132	Protein of unknown function, DUF480
H7691_RS18515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7691_RS18520	COG0210	DNA helicase
H7691_RS18535	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
H7691_RS18540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7691_RS18570	COG0840	transmembrane signaling receptor activity
H7691_RS18585	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7691_RS18605	COG1429	ligase activity, forming nitrogen-metal bonds
H7691_RS18610	COG4771	TonB-dependent receptor
H7691_RS18620	COG3186	Phenylalanine-4-hydroxylase
H7691_RS18630	COG2197	response regulator
H7691_RS18680	COG1741	Belongs to the pirin family
H7691_RS18685	COG0583	DNA-binding transcription factor activity
H7691_RS18695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7691_RS18700	COG1074	ATP-dependent DNA helicase activity
H7691_RS18705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7691_RS18710	COG1127	ABC transporter
H7691_RS18715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7691_RS18720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7691_RS18735	COG2853	Lipoprotein
H7691_RS18745	COG0386	Belongs to the glutathione peroxidase family
H7691_RS18775	COG0531	amino acid
H7691_RS18785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7691_RS18790	COG0861	Integral membrane protein TerC family
H7691_RS18800	COG0584	glycerophosphoryl diester phosphodiesterase
H7691_RS18805	COG0488	(ABC) transporter
H7691_RS18820	COG0706	membrane insertase activity
H7691_RS18825	COG0594	ribonuclease P activity
H7691_RS18830	COG0230	Belongs to the bacterial ribosomal protein bL34 family