locus-tag	class	description
K5K93_RS00015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K5K93_RS00020	COG0077	Prephenate dehydratase
K5K93_RS00020	COG1605	Chorismate mutase
K5K93_RS00025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K5K93_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5K93_RS00050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K5K93_RS00055	COG0583	DNA-binding transcription factor activity
K5K93_RS00115	COG0577	efflux transmembrane transporter activity
K5K93_RS00115	COG1136	(ABC) transporter
K5K93_RS00120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5K93_RS00135	COG0745	RESPONSE REGULATOR receiver
K5K93_RS00145	COG4774	siderophore transport
K5K93_RS00185	COG2814	Major facilitator Superfamily
K5K93_RS00200	COG3505	Type IV secretory pathway VirD4
K5K93_RS00210	COG3736	Type IV secretory pathway, component VirB8
K5K93_RS00220	COG2948	multi-organism process
K5K93_RS00240	COG3702	type iv secretory pathway
K5K93_RS00360	COG1902	pentaerythritol trinitrate reductase activity
K5K93_RS00365	COG0668	transmembrane transport
K5K93_RS00375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5K93_RS00405	COG3243	poly(R)-hydroxyalkanoic acid synthase
K5K93_RS00435	COG2183	response to ionizing radiation
K5K93_RS00440	COG5001	Diguanylate cyclase
K5K93_RS00440	COG5002	protein histidine kinase activity
K5K93_RS00440	COG3447	MASE1 domain protein
K5K93_RS00535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K93_RS00550	COG0531	amino acid
K5K93_RS00595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5K93_RS00610	COG0587	DNA-directed DNA polymerase activity
K5K93_RS00650	COG2814	Major facilitator Superfamily
K5K93_RS00665	COG2207	Transcriptional regulator
K5K93_RS00680	COG1285	pathogenesis
K5K93_RS00690	COG2186	Transcriptional regulator
K5K93_RS00695	COG1304	FMN binding
K5K93_RS00700	COG0277	FAD linked oxidase domain protein
K5K93_RS00740	COG3161	chorismate lyase activity
K5K93_RS00750	COG0583	DNA-binding transcription factor activity
K5K93_RS00760	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K5K93_RS00775	COG2197	response regulator
K5K93_RS00780	COG3850	Histidine kinase
K5K93_RS00795	COG1335	isochorismatase
K5K93_RS00805	COG1228	amidohydrolase
K5K93_RS00815	COG2814	Major facilitator Superfamily
K5K93_RS00870	COG4964	Belongs to the GSP D family
K5K93_RS00900	COG5295	Hep Hag repeat protein
K5K93_RS00905	COG2885	chlorophyll binding
K5K93_RS00905	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K5K93_RS00935	COG4772	TonB-dependent receptor
K5K93_RS00945	COG0583	DNA-binding transcription factor activity
K5K93_RS00965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5K93_RS00975	COG3321	synthase
K5K93_RS00975	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS00975	COG0604	alcohol dehydrogenase
K5K93_RS00980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K93_RS00985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K93_RS01000	COG1914	H( )-stimulated, divalent metal cation uptake system
K5K93_RS01050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5K93_RS01055	COG2409	Drug exporters of the RND superfamily
K5K93_RS01070	COG1021	2,3-dihydroxybenzoate-AMP ligase
K5K93_RS01075	COG3433	isochorismatase activity
K5K93_RS01075	COG1535	isochorismatase
K5K93_RS01085	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K5K93_RS01085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K5K93_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS01140	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K5K93_RS01155	COG1566	PFAM secretion protein HlyD family protein
K5K93_RS01170	COG2207	Transcriptional regulator
K5K93_RS01205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K5K93_RS01210	COG0521	Mo-molybdopterin cofactor biosynthetic process
K5K93_RS01210	COG0315	cyclic pyranopterin monophosphate synthase activity
K5K93_RS01215	COG0303	'Molybdopterin
K5K93_RS01225	COG0314	molybdopterin synthase activity
K5K93_RS01230	COG0746	molybdenum cofactor guanylyltransferase activity
K5K93_RS01240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K93_RS01250	COG4149	molybdate abc transporter
K5K93_RS01255	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K5K93_RS01260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K5K93_RS01265	COG0840	transmembrane signaling receptor activity
K5K93_RS01345	COG1459	type II secretion system
K5K93_RS01360	COG4795	General secretion pathway protein
K5K93_RS01390	COG0811	peptide transport
K5K93_RS01420	COG1335	isochorismatase
K5K93_RS01425	COG1335	isochorismatase
K5K93_RS01435	COG0583	DNA-binding transcription factor activity
K5K93_RS01455	COG0477	Major facilitator Superfamily
K5K93_RS01465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K93_RS01475	COG3537	Alpha-1,2-mannosidase
K5K93_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS01485	COG0583	DNA-binding transcription factor activity
K5K93_RS01500	COG1136	(ABC) transporter
K5K93_RS01525	COG0477	Major facilitator Superfamily
K5K93_RS01540	COG0243	molybdopterin cofactor binding
K5K93_RS01595	COG2205	protein histidine kinase activity
K5K93_RS01595	COG0784	Response regulator, receiver
K5K93_RS01600	COG2197	response regulator
K5K93_RS01605	COG2197	response regulator
K5K93_RS01620	COG3121	Chaperone
K5K93_RS01650	COG4566	intracellular signal transduction
K5K93_RS01655	COG4191	Histidine kinase
K5K93_RS01660	COG1285	pathogenesis
K5K93_RS01665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K93_RS01720	COG3214	Protein conserved in bacteria
K5K93_RS01725	COG0708	Exodeoxyribonuclease III
K5K93_RS01730	COG2199	diguanylate cyclase activity
K5K93_RS01750	COG2068	MobA-Related Protein
K5K93_RS01760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K5K93_RS01765	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K5K93_RS01770	COG2080	2 iron, 2 sulfur cluster binding
K5K93_RS01820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K5K93_RS01830	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
K5K93_RS01865	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K5K93_RS01890	COG0346	lactoylglutathione lyase activity
K5K93_RS01940	COG3685	Protein conserved in bacteria
K5K93_RS02015	COG0604	alcohol dehydrogenase
K5K93_RS02020	COG4221	oxidoreductase activity
K5K93_RS02025	COG1902	pentaerythritol trinitrate reductase activity
K5K93_RS02050	COG0318	PFAM AMP-dependent synthetase and ligase
K5K93_RS02065	COG0642	Histidine kinase
K5K93_RS02085	COG2610	gluconate transmembrane transporter activity
K5K93_RS02095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K5K93_RS02105	COG0431	NADPH-dependent FMN reductase
K5K93_RS02110	COG0583	DNA-binding transcription factor activity
K5K93_RS02115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K5K93_RS02130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5K93_RS02155	COG3459	Glycosyltransferase 36 associated
K5K93_RS02160	COG2207	Transcriptional regulator
K5K93_RS02205	COG3279	Response regulator of the LytR AlgR family
K5K93_RS02215	COG2194	sulfuric ester hydrolase activity
K5K93_RS02225	COG2205	protein histidine kinase activity
K5K93_RS02230	COG0745	RESPONSE REGULATOR receiver
K5K93_RS02235	COG0431	NADPH-dependent FMN reductase
K5K93_RS02270	COG1609	Transcriptional regulator
K5K93_RS02295	COG1070	Carbohydrate kinase
K5K93_RS02305	COG0477	Major facilitator Superfamily
K5K93_RS02310	COG1472	Belongs to the glycosyl hydrolase 3 family
K5K93_RS02320	COG3661	Belongs to the glycosyl hydrolase 67 family
K5K93_RS02335	COG1472	Belongs to the glycosyl hydrolase 3 family
K5K93_RS02380	COG1914	H( )-stimulated, divalent metal cation uptake system
K5K93_RS02460	COG0653	protein targeting
K5K93_RS02510	COG5002	protein histidine kinase activity
K5K93_RS02510	COG0784	Response regulator, receiver
K5K93_RS02525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5K93_RS02535	COG1120	ATPase activity
K5K93_RS02540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5K93_RS02545	COG4558	Periplasmic binding protein
K5K93_RS02555	COG2819	hydrolase of the alpha beta superfamily
K5K93_RS02570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5K93_RS02585	COG1674	ftsk spoiiie
K5K93_RS02590	COG0492	ferredoxin-NADP+ reductase activity
K5K93_RS02625	COG0542	response to heat
K5K93_RS02635	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K5K93_RS02650	COG0482	sulfurtransferase activity
K5K93_RS02655	COG2915	High frequency lysogenization protein hflD homolog
K5K93_RS02690	COG5002	protein histidine kinase activity
K5K93_RS02710	COG0835	chemotaxis
K5K93_RS02710	COG0784	Response regulator, receiver
K5K93_RS02720	COG1558	bacterial-type flagellum-dependent cell motility
K5K93_RS02725	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K5K93_RS02735	COG4787	bacterial-type flagellum-dependent cell motility
K5K93_RS02745	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K5K93_RS02785	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K5K93_RS02805	COG2197	response regulator
K5K93_RS02830	COG1677	Flagellar hook-basal body complex protein FliE
K5K93_RS02880	COG3190	flagellar
K5K93_RS02890	COG1987	bacterial-type flagellum assembly
K5K93_RS02905	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K5K93_RS02910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K5K93_RS02935	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K5K93_RS02940	COG0643	Histidine kinase
K5K93_RS02940	COG2198	Histidine kinase
K5K93_RS02940	COG0784	Response regulator, receiver
K5K93_RS02945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K5K93_RS02950	COG1360	Flagellar Motor Protein
K5K93_RS02960	COG0835	chemotaxis
K5K93_RS02970	COG0745	RESPONSE REGULATOR receiver
K5K93_RS02980	COG0840	transmembrane signaling receptor activity
K5K93_RS02985	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K5K93_RS02990	COG0835	chemotaxis
K5K93_RS03000	COG0840	transmembrane signaling receptor activity
K5K93_RS03005	COG0840	transmembrane signaling receptor activity
K5K93_RS03005	COG0840	transmembrane signaling receptor activity
K5K93_RS03015	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K5K93_RS03065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5K93_RS03070	COG1309	transcriptional regulator
K5K93_RS03075	COG1012	belongs to the aldehyde dehydrogenase family
K5K93_RS03080	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K5K93_RS03085	COG0318	PFAM AMP-dependent synthetase and ligase
K5K93_RS03090	COG1024	Enoyl-CoA hydratase
K5K93_RS03095	COG2205	protein histidine kinase activity
K5K93_RS03095	COG0784	Response regulator, receiver
K5K93_RS03095	COG2198	Histidine kinase
K5K93_RS03115	COG1012	belongs to the aldehyde dehydrogenase family
K5K93_RS03130	COG3279	Response regulator of the LytR AlgR family
K5K93_RS03150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5K93_RS03170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5K93_RS03175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5K93_RS03185	COG0505	Belongs to the CarA family
K5K93_RS03190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5K93_RS03195	COG0789	Transcriptional regulator
K5K93_RS03200	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5K93_RS03210	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5K93_RS03210	COG1918	ferrous iron import across plasma membrane
K5K93_RS03220	COG1024	Enoyl-CoA hydratase
K5K93_RS03245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K93_RS03265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5K93_RS03270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5K93_RS03275	COG0745	RESPONSE REGULATOR receiver
K5K93_RS03280	COG5002	protein histidine kinase activity
K5K93_RS03295	COG0277	FAD linked oxidase domain protein
K5K93_RS03300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5K93_RS03310	COG0531	amino acid
K5K93_RS03315	COG0531	amino acid
K5K93_RS03325	COG0235	Class ii aldolase
K5K93_RS03330	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K5K93_RS03335	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
K5K93_RS03350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5K93_RS03360	COG1609	Transcriptional regulator
K5K93_RS03365	COG3537	Alpha-1,2-mannosidase
K5K93_RS03380	COG0789	Transcriptional regulator
K5K93_RS03395	COG3142	Participates in the control of copper homeostasis
K5K93_RS03400	COG1446	asparaginase
K5K93_RS03405	COG0837	glucose binding
K5K93_RS03420	COG0140	phosphoribosyl-ATP diphosphatase activity
K5K93_RS03420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K5K93_RS03425	COG0107	imidazoleglycerol-phosphate synthase activity
K5K93_RS03430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K5K93_RS03435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K5K93_RS03440	COG0131	Imidazoleglycerol-phosphate dehydratase
K5K93_RS03440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K5K93_RS03445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5K93_RS03450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K5K93_RS03455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K5K93_RS03470	COG0124	histidyl-tRNA synthetase
K5K93_RS03475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K93_RS03480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K5K93_RS03490	COG0460	homoserine dehydrogenase
K5K93_RS03490	COG0527	aspartate kinase activity
K5K93_RS03525	COG0640	Transcriptional regulator
K5K93_RS03535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K93_RS03535	COG2205	protein histidine kinase activity
K5K93_RS03545	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K5K93_RS03550	COG2205	protein histidine kinase activity
K5K93_RS03550	COG3850	Histidine kinase
K5K93_RS03550	COG4999	Histidine kinase
K5K93_RS03550	COG3437	response regulator, receiver
K5K93_RS03555	COG0784	Response regulator, receiver
K5K93_RS03555	COG4191	Histidine kinase
K5K93_RS03575	COG0456	acetyltransferase
K5K93_RS03585	COG1012	belongs to the aldehyde dehydrogenase family
K5K93_RS03590	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS03605	COG0167	dihydroorotate dehydrogenase activity
K5K93_RS03610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5K93_RS03615	COG0697	spore germination
K5K93_RS03630	COG1309	transcriptional regulator
K5K93_RS03690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K93_RS03700	COG0456	acetyltransferase
K5K93_RS03705	COG1473	amidohydrolase
K5K93_RS03710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5K93_RS03715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5K93_RS03725	COG0431	NADPH-dependent FMN reductase
K5K93_RS03740	COG4716	Myosin-crossreactive antigen
K5K93_RS03760	COG0640	Transcriptional regulator
K5K93_RS03780	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS03815	COG0583	DNA-binding transcription factor activity
K5K93_RS03835	COG0519	Catalyzes the synthesis of GMP from XMP
K5K93_RS03835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5K93_RS03855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K5K93_RS03855	COG0475	glutathione-regulated potassium exporter activity
K5K93_RS03860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K5K93_RS03870	COG1160	GTP binding
K5K93_RS03875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5K93_RS03880	COG2976	Protein conserved in bacteria
K5K93_RS03885	COG1426	Protein conserved in bacteria
K5K93_RS03895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5K93_RS03900	COG0105	UTP biosynthetic process
K5K93_RS03910	COG1024	Enoyl-CoA hydratase
K5K93_RS03910	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K93_RS03915	COG0183	Belongs to the thiolase family
K5K93_RS03920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5K93_RS03930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5K93_RS03935	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K5K93_RS03945	COG0776	regulation of translation
K5K93_RS03955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5K93_RS03960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5K93_RS03970	COG2957	Belongs to the agmatine deiminase family
K5K93_RS03975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K5K93_RS03990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5K93_RS04015	COG0488	(ABC) transporter
K5K93_RS04020	COG0583	DNA-binding transcription factor activity
K5K93_RS04035	COG0513	Belongs to the DEAD box helicase family
K5K93_RS04040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K93_RS04045	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K5K93_RS04070	COG0564	pseudouridine synthase activity
K5K93_RS04080	COG2081	HI0933 family
K5K93_RS04090	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5K93_RS04095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5K93_RS04100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5K93_RS04105	COG1862	Preprotein translocase
K5K93_RS04110	COG0343	queuine tRNA-ribosyltransferase activity
K5K93_RS04115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5K93_RS04120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K5K93_RS04130	COG4251	negative regulation of phosphorylation
K5K93_RS04130	COG2203	Gaf domain
K5K93_RS04130	COG3706	GGDEF domain
K5K93_RS04130	COG5001	Diguanylate cyclase
K5K93_RS04150	COG1132	(ABC) transporter
K5K93_RS04160	COG1605	Chorismate mutase
K5K93_RS04160	COG0287	Prephenate dehydrogenase
K5K93_RS04165	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K5K93_RS04170	COG2223	nitrite transmembrane transporter activity
K5K93_RS04175	COG2207	Transcriptional regulator
K5K93_RS04180	COG0484	heat shock protein binding
K5K93_RS04185	COG0443	Heat shock 70 kDa protein
K5K93_RS04190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5K93_RS04195	COG1420	regulation of RNA biosynthetic process
K5K93_RS04200	COG0497	DNA recombination
K5K93_RS04205	COG0583	DNA-binding transcription factor activity
K5K93_RS04215	COG0735	belongs to the Fur family
K5K93_RS04220	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5K93_RS04225	COG2914	Belongs to the UPF0125 (RnfH) family
K5K93_RS04235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5K93_RS04295	COG0582	viral genome integration into host DNA
K5K93_RS04400	COG0583	DNA-binding transcription factor activity
K5K93_RS04405	COG2885	chlorophyll binding
K5K93_RS04410	COG0415	Belongs to the DNA photolyase family
K5K93_RS04440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5K93_RS04450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5K93_RS04455	COG0405	Gamma-glutamyltransferase
K5K93_RS04460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5K93_RS04470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5K93_RS04475	COG0742	ribosomal rna small subunit methyltransferase
K5K93_RS04490	COG0552	protein localization to endoplasmic reticulum
K5K93_RS04500	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K5K93_RS04515	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5K93_RS04540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K5K93_RS04545	COG2009	succinate dehydrogenase
K5K93_RS04570	COG0837	glucose binding
K5K93_RS04580	COG0129	dihydroxy-acid dehydratase activity
K5K93_RS04585	COG0800	Aldolase
K5K93_RS04595	COG0671	phosphoesterase, PA-phosphatase related
K5K93_RS04600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K5K93_RS04610	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K5K93_RS04615	COG0166	Belongs to the GPI family
K5K93_RS04620	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K5K93_RS04630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K5K93_RS04635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K5K93_RS04645	COG0617	tRNA 3'-terminal CCA addition
K5K93_RS04655	COG0477	Major facilitator Superfamily
K5K93_RS04660	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K5K93_RS04670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5K93_RS04680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K5K93_RS04685	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K5K93_RS04700	COG0352	thiamine-phosphate diphosphorylase activity
K5K93_RS04700	COG0351	phosphomethylpyrimidine kinase
K5K93_RS04725	COG0583	DNA-binding transcription factor activity
K5K93_RS04730	COG1741	Belongs to the pirin family
K5K93_RS04760	COG2223	nitrite transmembrane transporter activity
K5K93_RS04775	COG3258	Cytochrome c
K5K93_RS04790	COG3540	Alkaline phosphatase
K5K93_RS04805	COG1595	DNA-templated transcription, initiation
K5K93_RS04810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K5K93_RS04820	COG1201	RNA secondary structure unwinding
K5K93_RS04830	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K5K93_RS04835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5K93_RS04840	COG2137	regulation of response to DNA damage stimulus
K5K93_RS04845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5K93_RS04850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5K93_RS04855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5K93_RS04860	COG1546	Belongs to the CinA family
K5K93_RS04865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5K93_RS04870	COG1923	regulation of RNA biosynthetic process
K5K93_RS04875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5K93_RS04880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K5K93_RS04890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5K93_RS04895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K5K93_RS04900	COG1534	Rna-binding protein
K5K93_RS04920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K5K93_RS04925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K5K93_RS04930	COG2840	Smr protein MutS2
K5K93_RS04940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K5K93_RS04945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K5K93_RS04950	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K5K93_RS04955	COG0148	phosphopyruvate hydratase activity
K5K93_RS04970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K5K93_RS04975	COG0504	CTP synthase activity
K5K93_RS04990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5K93_RS05010	COG1253	flavin adenine dinucleotide binding
K5K93_RS05025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K5K93_RS05030	COG1054	Belongs to the UPF0176 family
K5K93_RS05055	COG0069	glutamate synthase activity
K5K93_RS05060	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K5K93_RS05085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5K93_RS05100	COG0348	domain, Protein
K5K93_RS05120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K5K93_RS05125	COG1917	Cupin 2, conserved barrel domain protein
K5K93_RS05125	COG4977	sequence-specific DNA binding
K5K93_RS05145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5K93_RS05185	COG0577	efflux transmembrane transporter activity
K5K93_RS05185	COG1136	(ABC) transporter
K5K93_RS05225	COG0322	excinuclease ABC activity
K5K93_RS05235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5K93_RS05240	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K5K93_RS05245	COG1663	tetraacyldisaccharide 4'-kinase activity
K5K93_RS05260	COG0811	peptide transport
K5K93_RS05265	COG0658	competence protein
K5K93_RS05265	COG2333	competence protein COMEC
K5K93_RS05270	COG2205	protein histidine kinase activity
K5K93_RS05280	COG3713	MltA-interacting MipA family protein
K5K93_RS05325	COG0556	nucleotide-excision repair
K5K93_RS05370	COG1611	Belongs to the LOG family
K5K93_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS05385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K5K93_RS05390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K5K93_RS05425	COG2969	positive regulation of protein catabolic process
K5K93_RS05430	COG0625	glutathione transferase activity
K5K93_RS05435	COG2857	Cytochrome c1
K5K93_RS05440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K5K93_RS05445	COG0723	plastoquinol--plastocyanin reductase activity
K5K93_RS05450	COG0741	lytic transglycosylase activity
K5K93_RS05465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5K93_RS05470	COG0842	Transport permease protein
K5K93_RS05475	COG1131	(ABC) transporter
K5K93_RS05480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5K93_RS05485	COG1702	phosphate starvation-inducible protein PhoH
K5K93_RS05495	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5K93_RS05510	COG4535	Mg2 and Co2 transporter CorC
K5K93_RS05525	COG1012	belongs to the aldehyde dehydrogenase family
K5K93_RS05530	COG1177	transmembrane transport
K5K93_RS05535	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5K93_RS05540	COG3842	ATPase activity
K5K93_RS05560	COG2072	flavoprotein involved in K transport
K5K93_RS05570	COG0174	glutamine synthetase
K5K93_RS05575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5K93_RS05580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5K93_RS05600	COG2703	oxygen carrier activity
K5K93_RS05605	COG0477	Major facilitator Superfamily
K5K93_RS05615	COG1012	belongs to the aldehyde dehydrogenase family
K5K93_RS05620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K5K93_RS05630	COG2733	membrane
K5K93_RS05655	COG0116	Belongs to the methyltransferase superfamily
K5K93_RS05655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5K93_RS05685	COG1024	Enoyl-CoA hydratase
K5K93_RS05695	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5K93_RS05710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5K93_RS05715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5K93_RS05720	COG0573	inorganic phosphate transmembrane transporter activity
K5K93_RS05725	COG0581	inorganic phosphate transmembrane transporter activity
K5K93_RS05735	COG0704	Plays a role in the regulation of phosphate uptake
K5K93_RS05745	COG3220	belongs to the UPF0276 family
K5K93_RS05755	COG2259	Doxx family
K5K93_RS05760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5K93_RS05780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5K93_RS05785	COG0577	efflux transmembrane transporter activity
K5K93_RS05785	COG1136	(ABC) transporter
K5K93_RS05790	COG1538	Outer membrane efflux protein
K5K93_RS05795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K93_RS05805	COG0557	exoribonuclease II activity
K5K93_RS05825	COG0583	DNA-binding transcription factor activity
K5K93_RS05835	COG2814	Major facilitator Superfamily
K5K93_RS05840	COG1566	PFAM secretion protein HlyD family protein
K5K93_RS05875	COG0475	glutathione-regulated potassium exporter activity
K5K93_RS05880	COG0367	asparagine synthase
K5K93_RS05890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K93_RS05895	COG1393	Belongs to the ArsC family
K5K93_RS05905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K5K93_RS05910	COG0024	Methionine aminopeptidase
K5K93_RS05925	COG3188	usher protein
K5K93_RS05940	COG0052	Belongs to the universal ribosomal protein uS2 family
K5K93_RS05945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5K93_RS05955	COG0528	UMP kinase activity
K5K93_RS05960	COG0233	cytoplasmic translational termination
K5K93_RS05965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5K93_RS05970	COG0575	Belongs to the CDS family
K5K93_RS05975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K5K93_RS05980	COG0750	zinc metalloprotease
K5K93_RS05990	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5K93_RS05995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5K93_RS06000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5K93_RS06025	COG0825	malonyl-CoA metabolic process
K5K93_RS06030	COG1981	membrane
K5K93_RS06090	COG1132	(ABC) transporter
K5K93_RS06120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5K93_RS06130	COG1187	pseudouridine synthase activity
K5K93_RS06145	COG5001	Diguanylate cyclase
K5K93_RS06145	COG5002	protein histidine kinase activity
K5K93_RS06225	COG0735	belongs to the Fur family
K5K93_RS06230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5K93_RS06245	COG4452	Inner membrane protein CreD
K5K93_RS06250	COG2205	protein histidine kinase activity
K5K93_RS06255	COG0745	RESPONSE REGULATOR receiver
K5K93_RS06260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K5K93_RS06270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5K93_RS06290	COG3590	peptidase
K5K93_RS06305	COG0588	phosphoglycerate mutase activity
K5K93_RS06310	COG1515	deoxyribonuclease V activity
K5K93_RS06325	COG3706	GGDEF domain
K5K93_RS06330	COG2814	Major facilitator Superfamily
K5K93_RS06355	COG1647	Serine aminopeptidase, S33
K5K93_RS06380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K5K93_RS06405	COG0024	Methionine aminopeptidase
K5K93_RS06425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5K93_RS06450	COG0840	transmembrane signaling receptor activity
K5K93_RS06620	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K5K93_RS06635	COG0534	Mate efflux family protein
K5K93_RS06655	COG0335	large ribosomal subunit rRNA binding
K5K93_RS06660	COG0336	Belongs to the RNA methyltransferase TrmD family
K5K93_RS06665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5K93_RS06670	COG0228	four-way junction DNA binding
K5K93_RS06695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5K93_RS06715	COG0326	Molecular chaperone. Has ATPase activity
K5K93_RS06730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K5K93_RS06735	COG1845	cytochrome c oxidase, subunit III
K5K93_RS06740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K5K93_RS06795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K93_RS06815	COG4206	TonB-dependent receptor
K5K93_RS06840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K5K93_RS06850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5K93_RS06855	COG0196	riboflavin kinase activity
K5K93_RS06860	COG0728	peptidoglycan biosynthetic process
K5K93_RS06865	COG0268	Binds directly to 16S ribosomal RNA
K5K93_RS06870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5K93_RS06880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K5K93_RS06885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5K93_RS06890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5K93_RS06895	COG0824	Thioesterase
K5K93_RS06915	COG1946	Acyl-CoA thioesterase
K5K93_RS06925	COG1595	DNA-templated transcription, initiation
K5K93_RS06935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K5K93_RS06945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K5K93_RS06965	COG1073	alpha beta
K5K93_RS06990	COG2197	response regulator
K5K93_RS06995	COG4585	Histidine kinase
K5K93_RS07010	COG2894	cell division
K5K93_RS07015	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K5K93_RS07030	COG0823	Involved in the tonB-independent uptake of proteins
K5K93_RS07030	COG1506	peptidase
K5K93_RS07035	COG1297	OPT oligopeptide transporter protein
K5K93_RS07045	COG3104	oligopeptide transport
K5K93_RS07085	COG0579	oxidoreductase
K5K93_RS07100	COG3052	prosthetic group binding
K5K93_RS07135	COG1802	Transcriptional regulator
K5K93_RS07150	COG0477	Major facilitator Superfamily
K5K93_RS07155	COG1408	metallophosphoesterase
K5K93_RS07160	COG1253	flavin adenine dinucleotide binding
K5K93_RS07165	COG3655	Transcriptional regulator
K5K93_RS07180	COG0640	Transcriptional regulator
K5K93_RS07215	COG0431	NADPH-dependent FMN reductase
K5K93_RS07225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5K93_RS07230	COG0798	PFAM Bile acid sodium symporter
K5K93_RS07235	COG2259	Doxx family
K5K93_RS07240	COG1609	Transcriptional regulator
K5K93_RS07250	COG2211	Major facilitator Superfamily
K5K93_RS07255	COG0673	inositol 2-dehydrogenase activity
K5K93_RS07265	COG2010	Cytochrome c
K5K93_RS07290	COG0629	single-stranded DNA binding
K5K93_RS07305	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K5K93_RS07315	COG1131	(ABC) transporter
K5K93_RS07340	COG0366	Alpha amylase catalytic
K5K93_RS07340	COG1874	Beta-galactosidase
K5K93_RS07345	COG2190	(PTS) system
K5K93_RS07345	COG2211	Major facilitator Superfamily
K5K93_RS07355	COG1082	Xylose isomerase domain protein TIM barrel
K5K93_RS07365	COG0366	Alpha amylase catalytic
K5K93_RS07370	COG0142	geranyltranstransferase activity
K5K93_RS07395	COG0527	aspartate kinase activity
K5K93_RS07405	COG0384	phenazine biosynthesis protein PhzF
K5K93_RS07410	COG1764	response to oxidative stress
K5K93_RS07435	COG0693	protein deglycase activity
K5K93_RS07445	COG1959	2 iron, 2 sulfur cluster binding
K5K93_RS07450	COG0719	Fe-S assembly protein
K5K93_RS07455	COG0396	ATPase activity
K5K93_RS07460	COG0719	Fe-S assembly protein
K5K93_RS07465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5K93_RS07490	COG2146	nitrite reductase [NAD(P)H] activity
K5K93_RS07500	COG4774	siderophore transport
K5K93_RS07510	COG3128	pkhd-type hydroxylase
K5K93_RS07520	COG4771	TonB-dependent receptor
K5K93_RS07540	COG1477	protein flavinylation
K5K93_RS07545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K5K93_RS07575	COG2261	transglycosylase associated protein
K5K93_RS07585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K5K93_RS07595	COG0628	permease
K5K93_RS07605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5K93_RS07625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5K93_RS07645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5K93_RS07660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K5K93_RS07675	COG1137	ATPase activity
K5K93_RS07685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K5K93_RS07690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K93_RS07695	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K5K93_RS07700	COG1660	Displays ATPase and GTPase activities
K5K93_RS07715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5K93_RS07720	COG2239	Acts as a magnesium transporter
K5K93_RS07740	COG0540	Belongs to the ATCase OTCase family
K5K93_RS07745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5K93_RS07750	COG1678	Uncharacterized ACR, COG1678
K5K93_RS07755	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K5K93_RS07760	COG2818	Glycosylase
K5K93_RS07780	COG0667	Aldo Keto reductase
K5K93_RS07815	COG0583	DNA-binding transcription factor activity
K5K93_RS07865	COG0745	RESPONSE REGULATOR receiver
K5K93_RS07880	COG0583	DNA-binding transcription factor activity
K5K93_RS07885	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS07890	COG0697	spore germination
K5K93_RS07895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K93_RS07915	COG2223	nitrite transmembrane transporter activity
K5K93_RS07925	COG4774	siderophore transport
K5K93_RS07975	COG1388	LysM domain
K5K93_RS08085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5K93_RS08090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5K93_RS08095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K5K93_RS08100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5K93_RS08115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5K93_RS08125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5K93_RS08130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5K93_RS08135	COG1399	metal-binding, possibly nucleic acid-binding protein
K5K93_RS08150	COG0714	Associated with various cellular activities
K5K93_RS08170	COG0537	adenosine 5'-monophosphoramidase activity
K5K93_RS08180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5K93_RS08210	COG2076	Multidrug Resistance protein
K5K93_RS08225	COG1234	tRNA 3'-trailer cleavage
K5K93_RS08230	COG3642	lipopolysaccharide core region biosynthetic process
K5K93_RS08235	COG0859	PFAM glycosyl transferase family 9
K5K93_RS08250	COG0631	protein serine/threonine phosphatase activity
K5K93_RS08255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5K93_RS08260	COG0328	RNA-DNA hybrid ribonuclease activity
K5K93_RS08270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5K93_RS08275	COG1388	LysM domain
K5K93_RS08275	COG3942	CHAP domain
K5K93_RS08280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5K93_RS08315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5K93_RS08325	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5K93_RS08395	COG0473	3-isopropylmalate dehydrogenase activity
K5K93_RS08410	COG4783	chaperone-mediated protein folding
K5K93_RS08425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K5K93_RS08430	COG0248	Ppx GppA phosphatase
K5K93_RS08435	COG4206	TonB-dependent receptor
K5K93_RS08440	COG0438	transferase activity, transferring glycosyl groups
K5K93_RS08445	COG0671	phosphoesterase, PA-phosphatase related
K5K93_RS08450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5K93_RS08455	COG3291	Pkd domain containing protein
K5K93_RS08465	COG2833	Protein of unknown function (DUF455)
K5K93_RS08485	COG0285	dihydrofolate synthase activity
K5K93_RS08490	COG0406	alpha-ribazole phosphatase activity
K5K93_RS08500	COG1063	alcohol dehydrogenase
K5K93_RS08520	COG1187	pseudouridine synthase activity
K5K93_RS08535	COG0604	alcohol dehydrogenase
K5K93_RS08540	COG2364	Membrane
K5K93_RS08545	COG1902	pentaerythritol trinitrate reductase activity
K5K93_RS08545	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K93_RS08555	COG0625	glutathione transferase activity
K5K93_RS08570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5K93_RS08580	COG0039	L-malate dehydrogenase activity
K5K93_RS08585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5K93_RS08600	COG0154	amidase activity
K5K93_RS08610	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K5K93_RS08625	COG0203	ribosomal protein L17
K5K93_RS08630	COG0202	RNA polymerase activity
K5K93_RS08635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5K93_RS08640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5K93_RS08645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5K93_RS08650	COG0201	protein transport
K5K93_RS08660	COG1841	ribosomal large subunit assembly
K5K93_RS08665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5K93_RS08670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K5K93_RS08675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5K93_RS08680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5K93_RS08685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5K93_RS08690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5K93_RS08695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5K93_RS08700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5K93_RS08705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5K93_RS08710	COG0255	Belongs to the universal ribosomal protein uL29 family
K5K93_RS08715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5K93_RS08720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5K93_RS08725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5K93_RS08730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5K93_RS08735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5K93_RS08740	COG0089	rRNA binding
K5K93_RS08745	COG0088	Forms part of the polypeptide exit tunnel
K5K93_RS08750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5K93_RS08755	COG0051	transcription antitermination factor activity, RNA binding
K5K93_RS08760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5K93_RS08765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5K93_RS08780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5K93_RS08785	COG0085	RNA polymerase activity
K5K93_RS08790	COG0222	ribosome binding
K5K93_RS08795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5K93_RS08800	COG0081	regulation of translation
K5K93_RS08805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5K93_RS08810	COG0250	Participates in transcription elongation, termination and antitermination
K5K93_RS08825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5K93_RS08850	COG4242	Belongs to the peptidase S51 family
K5K93_RS08855	COG4206	TonB-dependent receptor
K5K93_RS08860	COG2205	protein histidine kinase activity
K5K93_RS08860	COG0784	Response regulator, receiver
K5K93_RS08865	COG2199	diguanylate cyclase activity
K5K93_RS08865	COG2200	EAL domain
K5K93_RS08865	COG2203	Gaf domain
K5K93_RS08870	COG0784	Response regulator, receiver
K5K93_RS08870	COG2205	protein histidine kinase activity
K5K93_RS08875	COG2197	response regulator
K5K93_RS08885	COG0012	GTP binding
K5K93_RS08895	COG0193	aminoacyl-tRNA hydrolase activity
K5K93_RS08905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5K93_RS08915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5K93_RS08930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K5K93_RS08935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5K93_RS08950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K93_RS08955	COG1295	ribonuclease BN
K5K93_RS08975	COG1404	Belongs to the peptidase S8 family
K5K93_RS08980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5K93_RS09020	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K5K93_RS09060	COG0583	DNA-binding transcription factor activity
K5K93_RS09080	COG3634	alkyl hydroperoxide reductase activity
K5K93_RS09085	COG0583	DNA-binding transcription factor activity
K5K93_RS09090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5K93_RS09100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5K93_RS09110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5K93_RS09125	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K5K93_RS09135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5K93_RS09140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5K93_RS09150	COG2096	Adenosyltransferase
K5K93_RS09160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K5K93_RS09170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K5K93_RS09180	COG2967	ApaG domain
K5K93_RS09185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K5K93_RS09190	COG3738	Protein conserved in bacteria
K5K93_RS09205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5K93_RS09210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5K93_RS09225	COG1704	LemA family
K5K93_RS09230	COG2814	Major facilitator Superfamily
K5K93_RS09235	COG0861	Integral membrane protein TerC family
K5K93_RS09240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5K93_RS09250	COG0642	Histidine kinase
K5K93_RS09265	COG4181	ATPase activity
K5K93_RS09270	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K5K93_RS09295	COG4771	TonB-dependent receptor
K5K93_RS09305	COG0667	Aldo Keto reductase
K5K93_RS09310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K5K93_RS09320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K93_RS09325	COG4106	trans-aconitate 2-methyltransferase activity
K5K93_RS09345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5K93_RS09350	COG1607	acyl-coa hydrolase
K5K93_RS09355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K5K93_RS09365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K5K93_RS09370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5K93_RS09395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K5K93_RS09405	COG0494	nUDIX hydrolase
K5K93_RS09410	COG0653	protein targeting
K5K93_RS09415	COG0739	heme binding
K5K93_RS09425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K5K93_RS09430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5K93_RS09440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5K93_RS09445	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K93_RS09450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5K93_RS09470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5K93_RS09475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5K93_RS09485	COG3116	cell division
K5K93_RS09490	COG0275	rRNA processing
K5K93_RS09495	COG2001	Belongs to the MraZ family
K5K93_RS09525	COG1988	membrane-bound metal-dependent
K5K93_RS09530	COG0277	FAD linked oxidase domain protein
K5K93_RS09535	COG2755	lipolytic protein G-D-S-L family
K5K93_RS09535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5K93_RS09570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K93_RS09575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K5K93_RS09605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5K93_RS09605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5K93_RS09610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5K93_RS09625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5K93_RS09640	COG0488	(ABC) transporter
K5K93_RS09650	COG2252	PERMEase
K5K93_RS09660	COG1960	acyl-CoA dehydrogenase activity
K5K93_RS09680	COG1696	Membrane protein involved in D-alanine export
K5K93_RS09700	COG1215	transferase activity, transferring glycosyl groups
K5K93_RS09710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5K93_RS09720	COG0463	Glycosyl transferase, family 2
K5K93_RS09730	COG1450	Type ii and iii secretion system protein
K5K93_RS09745	COG3166	PFAM Fimbrial assembly family protein
K5K93_RS09750	COG3156	type II secretion system protein K
K5K93_RS09755	COG4795	General secretion pathway protein
K5K93_RS09760	COG2165	general secretion pathway protein
K5K93_RS09765	COG4970	Tfp pilus assembly protein FimT
K5K93_RS09770	COG2165	general secretion pathway protein
K5K93_RS09775	COG1459	type II secretion system
K5K93_RS09780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5K93_RS09785	COG1404	Belongs to the peptidase S8 family
K5K93_RS09790	COG5295	Hep Hag repeat protein
K5K93_RS09795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5K93_RS09795	COG0047	phosphoribosylformylglycinamidine synthase activity
K5K93_RS09805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5K93_RS09810	COG4974	Belongs to the 'phage' integrase family
K5K93_RS09820	COG0795	lipopolysaccharide-transporting ATPase activity
K5K93_RS09830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K5K93_RS09845	COG0525	valine-tRNA ligase activity
K5K93_RS09865	COG1183	phosphatidylcholine synthase activity
K5K93_RS09875	COG0442	prolyl-tRNA aminoacylation
K5K93_RS09890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K5K93_RS09895	COG1127	ABC transporter
K5K93_RS09925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5K93_RS09985	COG2076	Multidrug Resistance protein
K5K93_RS09990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5K93_RS10005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K5K93_RS10025	COG0438	transferase activity, transferring glycosyl groups
K5K93_RS10040	COG0626	cystathionine gamma-synthase activity
K5K93_RS10075	COG1573	uracil-dna glycosylase
K5K93_RS10080	COG0625	glutathione transferase activity
K5K93_RS10090	COG0513	Belongs to the DEAD box helicase family
K5K93_RS10105	COG0720	synthase
K5K93_RS10115	COG0745	RESPONSE REGULATOR receiver
K5K93_RS10120	COG2205	protein histidine kinase activity
K5K93_RS10125	COG5002	protein histidine kinase activity
K5K93_RS10130	COG0745	RESPONSE REGULATOR receiver
K5K93_RS10135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5K93_RS10140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K93_RS10140	COG0785	Cytochrome C biogenesis protein
K5K93_RS10145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5K93_RS10150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K93_RS10155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K5K93_RS10160	COG1956	GAF domain-containing protein
K5K93_RS10185	COG2226	methyltransferase
K5K93_RS10190	COG0583	DNA-binding transcription factor activity
K5K93_RS10205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K93_RS10210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5K93_RS10220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5K93_RS10225	COG1187	pseudouridine synthase activity
K5K93_RS10230	COG2813	Specifically methylates the guanine in position
K5K93_RS10245	COG2205	protein histidine kinase activity
K5K93_RS10260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5K93_RS10290	COG1360	Flagellar Motor Protein
K5K93_RS10315	COG0025	NhaP-type Na H and K H
K5K93_RS10320	COG3384	dioxygenase
K5K93_RS10325	COG0583	DNA-binding transcription factor activity
K5K93_RS10330	COG5001	Diguanylate cyclase
K5K93_RS10335	COG3590	peptidase
K5K93_RS10355	COG3279	Response regulator of the LytR AlgR family
K5K93_RS10360	COG3275	phosphorelay sensor kinase activity
K5K93_RS10390	COG4941	Belongs to the sigma-70 factor family
K5K93_RS10395	COG5507	3-demethylubiquinone-9 3-methyltransferase
K5K93_RS10405	COG2764	glyoxalase bleomycin resistance protein dioxygenase
K5K93_RS10440	COG1113	amino acid transport
K5K93_RS10445	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K5K93_RS10450	COG2814	Major facilitator Superfamily
K5K93_RS10460	COG0583	DNA-binding transcription factor activity
K5K93_RS10465	COG0488	(ABC) transporter
K5K93_RS10530	COG2267	carboxylic ester hydrolase activity
K5K93_RS10665	COG2375	cellular response to nickel ion
K5K93_RS10680	COG2353	YceI-like domain
K5K93_RS10685	COG0778	Nitroreductase
K5K93_RS10710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K5K93_RS10715	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K5K93_RS10725	COG5383	Protein conserved in bacteria
K5K93_RS10750	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K5K93_RS10775	COG4948	Mandelate Racemase Muconate Lactonizing
K5K93_RS10780	COG1737	Transcriptional regulator
K5K93_RS10790	COG0531	amino acid
K5K93_RS10800	COG4682	membrane
K5K93_RS10805	COG2133	pyrroloquinoline quinone binding
K5K93_RS10820	COG0668	transmembrane transport
K5K93_RS10825	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K5K93_RS10835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5K93_RS10845	COG1610	YqeY-like protein
K5K93_RS10850	COG1295	ribonuclease BN
K5K93_RS10855	COG0358	DNA primase activity
K5K93_RS10875	COG0109	protoheme IX farnesyltransferase activity
K5K93_RS10915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K5K93_RS10920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K5K93_RS10950	COG2067	long-chain fatty acid transport protein
K5K93_RS10960	COG0793	Belongs to the peptidase S41A family
K5K93_RS10965	COG4942	peptidase
K5K93_RS10975	COG2234	aminopeptidase activity
K5K93_RS11035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5K93_RS11040	COG0739	heme binding
K5K93_RS11055	COG2223	nitrite transmembrane transporter activity
K5K93_RS11060	COG0708	Exodeoxyribonuclease III
K5K93_RS11065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K5K93_RS11080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K5K93_RS11085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K5K93_RS11095	COG2205	protein histidine kinase activity
K5K93_RS11110	COG0756	dUTP diphosphatase activity
K5K93_RS11115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5K93_RS11120	COG2197	response regulator
K5K93_RS11125	COG2003	Belongs to the UPF0758 family
K5K93_RS11130	COG0018	arginyl-trna synthetase
K5K93_RS11140	COG4221	oxidoreductase activity
K5K93_RS11150	COG4807	Protein conserved in bacteria
K5K93_RS11155	COG0583	DNA-binding transcription factor activity
K5K93_RS11160	COG2814	Major facilitator Superfamily
K5K93_RS11175	COG2200	EAL domain
K5K93_RS11175	COG2771	luxR family
K5K93_RS11185	COG5507	3-demethylubiquinone-9 3-methyltransferase
K5K93_RS11200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5K93_RS11220	COG0628	permease
K5K93_RS11230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K5K93_RS11240	COG3038	cytochrome b561
K5K93_RS11245	COG2197	response regulator
K5K93_RS11250	COG4585	Histidine kinase
K5K93_RS11260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5K93_RS11265	COG1136	(ABC) transporter
K5K93_RS11275	COG1136	(ABC) transporter
K5K93_RS11275	COG0577	efflux transmembrane transporter activity
K5K93_RS11290	COG0697	spore germination
K5K93_RS11305	COG4152	abc transporter atp-binding protein
K5K93_RS11315	COG0477	Major facilitator Superfamily
K5K93_RS11340	COG0180	Tryptophanyl-tRNA synthetase
K5K93_RS11350	COG3237	CsbD-like
K5K93_RS11415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K5K93_RS11420	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K5K93_RS11420	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K5K93_RS11455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K93_RS11490	COG0659	secondary active sulfate transmembrane transporter activity
K5K93_RS11500	COG1764	response to oxidative stress
K5K93_RS11510	COG1024	Enoyl-CoA hydratase
K5K93_RS11515	COG1024	Enoyl-CoA hydratase
K5K93_RS11520	COG1960	acyl-CoA dehydrogenase activity
K5K93_RS11530	COG1396	sequence-specific DNA binding
K5K93_RS11530	COG3800	Transcriptional regulator
K5K93_RS11540	COG1752	Esterase of the alpha-beta hydrolase superfamily
K5K93_RS11545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5K93_RS11550	COG1335	isochorismatase
K5K93_RS11575	COG1902	pentaerythritol trinitrate reductase activity
K5K93_RS11585	COG1607	acyl-coa hydrolase
K5K93_RS11590	COG1280	lysine exporter protein (LysE YggA)
K5K93_RS11595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K93_RS11605	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K5K93_RS11615	COG0697	spore germination
K5K93_RS11635	COG1960	acyl-CoA dehydrogenase activity
K5K93_RS11640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5K93_RS11670	COG2224	Isocitrate lyase
K5K93_RS11675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K5K93_RS11680	COG0583	DNA-binding transcription factor activity
K5K93_RS11685	COG0583	DNA-binding transcription factor activity
K5K93_RS11690	COG2814	Major facilitator Superfamily
K5K93_RS11695	COG0681	Belongs to the peptidase S26 family
K5K93_RS11710	COG0339	signal peptide processing
K5K93_RS11730	COG0564	pseudouridine synthase activity
K5K93_RS11740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K5K93_RS11745	COG1215	transferase activity, transferring glycosyl groups
K5K93_RS11760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5K93_RS11770	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K93_RS11780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5K93_RS11785	COG0318	PFAM AMP-dependent synthetase and ligase
K5K93_RS11795	COG0596	Alpha beta hydrolase
K5K93_RS11800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5K93_RS11810	COG0612	Peptidase, M16
K5K93_RS11820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5K93_RS11825	COG1960	acyl-CoA dehydrogenase activity
K5K93_RS11835	COG3474	cytochrome
K5K93_RS11840	COG2205	protein histidine kinase activity
K5K93_RS11840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K93_RS11845	COG2197	response regulator
K5K93_RS11885	COG2837	iron assimilation
K5K93_RS11955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5K93_RS11960	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K5K93_RS11995	COG0183	Belongs to the thiolase family
K5K93_RS12005	COG2032	superoxide dismutase activity
K5K93_RS12010	COG2032	superoxide dismutase activity
K5K93_RS12015	COG2204	response regulator
K5K93_RS12020	COG3852	Histidine kinase
K5K93_RS12035	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K5K93_RS12050	COG3279	Response regulator of the LytR AlgR family
K5K93_RS12060	COG0004	ammonium transporteR
K5K93_RS12065	COG0347	Belongs to the P(II) protein family
K5K93_RS12070	COG0174	glutamine synthetase
K5K93_RS12075	COG1968	undecaprenyl-diphosphatase activity
K5K93_RS12115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K93_RS12135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5K93_RS12160	COG0312	modulator of DNA gyrase
K5K93_RS12180	COG0714	Associated with various cellular activities
K5K93_RS12220	COG1111	helicase
K5K93_RS12220	COG1205	dead DEAH box helicase
K5K93_RS12245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5K93_RS12250	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS12270	COG0069	glutamate synthase activity
K5K93_RS12270	COG0070	glutamate synthase
K5K93_RS12270	COG0067	glutamate synthase
K5K93_RS12275	COG0493	'glutamate synthase
K5K93_RS12280	COG2205	protein histidine kinase activity
K5K93_RS12280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K93_RS12285	COG1803	Methylglyoxal synthase
K5K93_RS12295	COG2974	May be involved in recombination
K5K93_RS12300	COG0037	tRNA processing
K5K93_RS12315	COG2937	Belongs to the GPAT DAPAT family
K5K93_RS12325	COG5640	endopeptidase activity
K5K93_RS12330	COG0284	orotidine-5'-phosphate decarboxylase activity
K5K93_RS12335	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K5K93_RS12340	COG3132	Protein of unknown function, DUF480
K5K93_RS12360	COG0210	DNA helicase
K5K93_RS12365	COG1435	thymidine kinase activity
K5K93_RS12375	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K5K93_RS12380	COG0515	serine threonine protein kinase
K5K93_RS12380	COG2815	serine threonine protein kinase
K5K93_RS12390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5K93_RS12405	COG1122	ATPase activity
K5K93_RS12425	COG4771	TonB-dependent receptor
K5K93_RS12435	COG1752	Esterase of the alpha-beta hydrolase superfamily
K5K93_RS12445	COG1522	sequence-specific DNA binding
K5K93_RS12450	COG3186	Phenylalanine-4-hydroxylase
K5K93_RS12460	COG2755	lipolytic protein G-D-S-L family
K5K93_RS12470	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS12480	COG1609	Transcriptional regulator
K5K93_RS12485	COG3507	Belongs to the glycosyl hydrolase 43 family
K5K93_RS12500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5K93_RS12515	COG2272	Belongs to the type-B carboxylesterase lipase family
K5K93_RS12535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5K93_RS12540	COG0800	Aldolase
K5K93_RS12545	COG3284	Transcriptional regulator
K5K93_RS12550	COG1012	belongs to the aldehyde dehydrogenase family
K5K93_RS12585	COG4772	TonB-dependent receptor
K5K93_RS12595	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K5K93_RS12650	COG0501	Belongs to the peptidase M48B family
K5K93_RS12655	COG1266	CAAX protease self-immunity
K5K93_RS12660	COG0187	DNA topoisomerase II activity
K5K93_RS12665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5K93_RS12675	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5K93_RS12680	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K5K93_RS12685	COG0594	ribonuclease P activity
K5K93_RS12690	COG0706	membrane insertase activity
K5K93_RS12715	COG0584	glycerophosphoryl diester phosphodiesterase
K5K93_RS12725	COG0861	Integral membrane protein TerC family
K5K93_RS12730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5K93_RS12750	COG0531	amino acid
K5K93_RS12760	COG0667	Aldo Keto reductase
K5K93_RS12775	COG0583	DNA-binding transcription factor activity
K5K93_RS12790	COG1322	Protein conserved in bacteria
K5K93_RS12800	COG0386	Belongs to the glutathione peroxidase family
K5K93_RS12805	COG2853	Lipoprotein
K5K93_RS12820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K5K93_RS12825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K5K93_RS12830	COG1127	ABC transporter
K5K93_RS12835	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K5K93_RS12840	COG1074	ATP-dependent DNA helicase activity
K5K93_RS12855	COG1289	transmembrane transporter activity
K5K93_RS12860	COG1538	Outer membrane efflux protein
K5K93_RS12865	COG1566	PFAM secretion protein HlyD family protein
K5K93_RS12880	COG0302	gtp cyclohydrolase
K5K93_RS12915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K5K93_RS12920	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K5K93_RS12925	COG0676	glucose-6-phosphate 1-epimerase activity
K5K93_RS12935	COG3135	benzoate transporter
K5K93_RS12990	COG0840	transmembrane signaling receptor activity
K5K93_RS13005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5K93_RS13015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5K93_RS13025	COG0805	protein transport
K5K93_RS13035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5K93_RS13035	COG0519	Catalyzes the synthesis of GMP from XMP
K5K93_RS13040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5K93_RS13045	COG0752	glycyl-tRNA synthetase alpha subunit
K5K93_RS13055	COG0729	surface antigen
K5K93_RS13060	COG2911	Protein conserved in bacteria
K5K93_RS13070	COG2205	protein histidine kinase activity
K5K93_RS13070	COG0784	Response regulator, receiver
K5K93_RS13075	COG1971	Probably functions as a manganese efflux pump
K5K93_RS13115	COG2091	lysine biosynthetic process via aminoadipic acid
K5K93_RS13120	COG0357	Ribosomal RNA small subunit methyltransferase G
K5K93_RS13125	COG1192	Involved in chromosome partitioning
K5K93_RS13130	COG1475	DNA binding
K5K93_RS13145	COG0463	Glycosyl transferase, family 2
K5K93_RS13180	COG0251	oxidation-reduction process
K5K93_RS13190	COG1819	glycosyl
K5K93_RS13200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5K93_RS13205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K93_RS13210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K93_RS13220	COG0210	DNA helicase
K5K93_RS13240	COG4650	regulator
K5K93_RS13250	COG1690	Belongs to the RtcB family
K5K93_RS13260	COG0589	response to stress
K5K93_RS13275	COG2323	membrane
K5K93_RS13280	COG0408	coproporphyrinogen oxidase activity
K5K93_RS13315	COG1595	DNA-templated transcription, initiation
K5K93_RS13325	COG1271	oxidase subunit
K5K93_RS13330	COG1294	oxidase, subunit
K5K93_RS13345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K93_RS13350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K93_RS13360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5K93_RS13365	COG0463	Glycosyl transferase, family 2
K5K93_RS13375	COG2986	histidine ammonia-lyase
K5K93_RS13395	COG0644	oxidoreductase
K5K93_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS13430	COG3100	YcgL domain-containing protein
K5K93_RS13435	COG3177	Filamentation induced by cAMP protein fic
K5K93_RS13435	COG0666	response to abiotic stimulus
K5K93_RS13445	COG2239	Acts as a magnesium transporter
K5K93_RS13450	COG0045	succinate-CoA ligase (ADP-forming) activity
K5K93_RS13450	COG1042	CoA-binding domain protein
K5K93_RS13450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5K93_RS13455	COG0393	Putative heavy-metal-binding
K5K93_RS13460	COG2267	carboxylic ester hydrolase activity
K5K93_RS13470	COG2814	Major facilitator Superfamily
K5K93_RS13475	COG0583	DNA-binding transcription factor activity
K5K93_RS13495	COG0667	Aldo Keto reductase
K5K93_RS13505	COG1187	pseudouridine synthase activity
K5K93_RS13515	COG1643	Atp-dependent helicase
K5K93_RS13520	COG0084	hydrolase, TatD family'
K5K93_RS13530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5K93_RS13535	COG0842	Transport permease protein
K5K93_RS13540	COG1131	(ABC) transporter
K5K93_RS13570	COG4555	ABC transporter
K5K93_RS13580	COG2207	Transcriptional regulator
K5K93_RS13600	COG0625	glutathione transferase activity
K5K93_RS13630	COG3781	membrane
K5K93_RS13650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5K93_RS13660	COG1199	ATP-dependent helicase activity
K5K93_RS13670	COG0129	dihydroxy-acid dehydratase activity
K5K93_RS13680	COG0754	glutathionylspermidine amidase activity
K5K93_RS13695	COG0714	Associated with various cellular activities
K5K93_RS13720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K5K93_RS13725	COG3541	Predicted nucleotidyltransferase
K5K93_RS13740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K5K93_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS13760	COG2267	carboxylic ester hydrolase activity
K5K93_RS13765	COG0156	8-amino-7-oxononanoate synthase activity
K5K93_RS13770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K5K93_RS13785	COG1040	competence protein
K5K93_RS13800	COG2814	Major facilitator Superfamily
K5K93_RS13805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5K93_RS13810	COG1349	DNA-binding transcription factor activity
K5K93_RS13820	COG1940	carbohydrate kinase activity
K5K93_RS13825	COG2222	sugar isomerase
K5K93_RS13830	COG1501	Belongs to the glycosyl hydrolase 31 family
K5K93_RS13840	COG0673	inositol 2-dehydrogenase activity
K5K93_RS13900	COG2031	fatty acid transporter
K5K93_RS13905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5K93_RS13935	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K5K93_RS13965	COG1104	cysteine desulfurase activity
K5K93_RS13970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K93_RS13985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K93_RS13990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K5K93_RS14000	COG1845	cytochrome c oxidase, subunit III
K5K93_RS14005	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K5K93_RS14010	COG1999	signal sequence binding
K5K93_RS14040	COG3932	Exopolysaccharide synthesis, ExoD
K5K93_RS14045	COG0561	phosphatase activity
K5K93_RS14070	COG0606	chelatase, subunit chli
K5K93_RS14110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5K93_RS14110	COG0784	Response regulator, receiver
K5K93_RS14145	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K5K93_RS14150	COG1166	arginine decarboxylase activity
K5K93_RS14170	COG3212	peptidase
K5K93_RS14185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5K93_RS14185	COG0723	plastoquinol--plastocyanin reductase activity
K5K93_RS14200	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K5K93_RS14200	COG3264	Mechanosensitive ion channel
K5K93_RS14205	COG1368	sulfuric ester hydrolase activity
K5K93_RS14215	COG2354	Protein conserved in bacteria
K5K93_RS14230	COG2378	regulation of single-species biofilm formation
K5K93_RS14255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K93_RS14260	COG3483	tryptophan 2,3-dioxygenase activity
K5K93_RS14265	COG3104	oligopeptide transport
K5K93_RS14280	COG4804	nuclease activity
K5K93_RS14300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K5K93_RS14320	COG1320	monovalent cation:proton antiporter activity
K5K93_RS14325	COG2212	antiporter activity
K5K93_RS14330	COG1863	multisubunit Na H antiporter MnhE subunit
K5K93_RS14335	COG0651	ATP synthesis coupled electron transport
K5K93_RS14340	COG1006	Multisubunit Na H antiporter MnhC subunit
K5K93_RS14345	COG2111	Na H antiporter
K5K93_RS14345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K5K93_RS14355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5K93_RS14360	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K5K93_RS14375	COG1597	lipid kinase activity
K5K93_RS14395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K5K93_RS14410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K5K93_RS14415	COG0134	indole-3-glycerol-phosphate synthase activity
K5K93_RS14425	COG0730	response to heat
K5K93_RS14430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K93_RS14435	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K5K93_RS14445	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K5K93_RS14450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5K93_RS14455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5K93_RS14470	COG1051	belongs to the nudix hydrolase family
K5K93_RS14515	COG0316	Belongs to the HesB IscA family
K5K93_RS14550	COG1289	transmembrane transporter activity
K5K93_RS14570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5K93_RS14575	COG1473	amidohydrolase
K5K93_RS14580	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K5K93_RS14580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K5K93_RS14585	COG1652	LysM domain
K5K93_RS14625	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
K5K93_RS14635	COG3706	GGDEF domain
K5K93_RS14640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K5K93_RS14645	COG3118	belongs to the thioredoxin family
K5K93_RS14655	COG2884	Cell division ATP-binding protein ftsE
K5K93_RS14660	COG2177	Part of the ABC transporter FtsEX involved in
K5K93_RS14665	COG2201	protein-glutamate methylesterase activity
K5K93_RS14670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K5K93_RS14675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5K93_RS14680	COG0151	Belongs to the GarS family
K5K93_RS14690	COG0138	bifunctional purine biosynthesis protein purh
K5K93_RS14695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5K93_RS14700	COG2267	carboxylic ester hydrolase activity
K5K93_RS14705	COG2453	phosphatase
K5K93_RS14705	COG0671	phosphoesterase, PA-phosphatase related
K5K93_RS14720	COG4589	Belongs to the CDS family
K5K93_RS14725	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K5K93_RS14735	COG2264	protein methyltransferase activity
K5K93_RS14750	COG0439	Biotin carboxylase
K5K93_RS14755	COG0511	ligase activity, forming carbon-carbon bonds
K5K93_RS14765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K5K93_RS14780	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5K93_RS14795	COG1686	Belongs to the peptidase S11 family
K5K93_RS14805	COG0583	DNA-binding transcription factor activity
K5K93_RS14825	COG0840	transmembrane signaling receptor activity
K5K93_RS14835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K93_RS14840	COG4232	protein-disulfide reductase activity
K5K93_RS14845	COG1324	tolerance protein
K5K93_RS14850	COG2356	endonuclease I
K5K93_RS14855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K5K93_RS14860	COG0459	protein refolding
K5K93_RS14870	COG1846	Transcriptional regulator
K5K93_RS14890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5K93_RS14895	COG2860	membrane
K5K93_RS14910	COG1252	NADH dehydrogenase
K5K93_RS14925	COG0625	glutathione transferase activity
K5K93_RS14930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5K93_RS14945	COG0534	Mate efflux family protein
K5K93_RS14950	COG0616	signal peptide processing
K5K93_RS14975	COG0009	L-threonylcarbamoyladenylate synthase
K5K93_RS14980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5K93_RS14980	COG1754	DNA topoisomerase type I activity
K5K93_RS14985	COG1714	RDD family
K5K93_RS14990	COG4969	Belongs to the N-Me-Phe pilin family
K5K93_RS14995	COG2922	Belongs to the Smg family
K5K93_RS15000	COG0758	DNA mediated transformation
K5K93_RS15005	COG1652	LysM domain
K5K93_RS15010	COG0242	peptide deformylase activity
K5K93_RS15015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5K93_RS15020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5K93_RS15020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K93_RS15025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K5K93_RS15065	COG1490	D-aminoacyl-tRNA deacylase activity
K5K93_RS15070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5K93_RS15105	COG1733	regulation of RNA biosynthetic process
K5K93_RS15115	COG0625	glutathione transferase activity
K5K93_RS15160	COG0583	DNA-binding transcription factor activity
K5K93_RS15200	COG4771	TonB-dependent receptor
K5K93_RS15210	COG0400	carboxylic ester hydrolase activity
K5K93_RS15215	COG3275	phosphorelay sensor kinase activity
K5K93_RS15225	COG0181	hydroxymethylbilane synthase activity
K5K93_RS15250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5K93_RS15270	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5K93_RS15275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K93_RS15290	COG0356	it plays a direct role in the translocation of protons across the membrane
K5K93_RS15300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5K93_RS15305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K93_RS15310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5K93_RS15315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5K93_RS15320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5K93_RS15325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5K93_RS15340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K5K93_RS15355	COG2204	response regulator
K5K93_RS15365	COG0577	efflux transmembrane transporter activity
K5K93_RS15365	COG1136	(ABC) transporter
K5K93_RS15375	COG1136	(ABC) transporter
K5K93_RS15385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K5K93_RS15405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5K93_RS15415	COG0339	signal peptide processing
K5K93_RS15445	COG1666	GTP binding
K5K93_RS15450	COG0697	spore germination
K5K93_RS15455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K93_RS15460	COG2011	ABC-type metal ion transport system permease component
K5K93_RS15475	COG1505	serine-type exopeptidase activity
K5K93_RS15480	COG0436	Aminotransferase
K5K93_RS15490	COG2832	Protein of unknown function (DUF454)
K5K93_RS15500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K5K93_RS15520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K5K93_RS15535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5K93_RS15540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5K93_RS15550	COG1943	Transposase
K5K93_RS15575	COG2226	methyltransferase
K5K93_RS15580	COG0308	aminopeptidase N
K5K93_RS15595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5K93_RS15600	COG1077	Cell shape determining protein MreB Mrl
K5K93_RS15605	COG1792	Involved in formation and maintenance of cell shape
K5K93_RS15615	COG0768	penicillin binding
K5K93_RS15620	COG0772	Belongs to the SEDS family
K5K93_RS15630	COG0772	Belongs to the SEDS family
K5K93_RS15635	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
K5K93_RS15645	COG2951	lytic endotransglycosylase activity
K5K93_RS15655	COG1686	Belongs to the peptidase S11 family
K5K93_RS15665	COG2921	Belongs to the UPF0250 family
K5K93_RS15675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K5K93_RS15695	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5K93_RS15700	COG0673	inositol 2-dehydrogenase activity
K5K93_RS15705	COG2823	Periplasmic or secreted lipoprotein
K5K93_RS15710	COG4251	negative regulation of phosphorylation
K5K93_RS15715	COG0784	Response regulator, receiver
K5K93_RS15730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K5K93_RS15750	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K5K93_RS15760	COG0837	glucose binding
K5K93_RS15770	COG1609	Transcriptional regulator
K5K93_RS15775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K5K93_RS15780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5K93_RS15790	COG3468	outer membrane autotransporter barrel domain protein
K5K93_RS15815	COG0617	tRNA 3'-terminal CCA addition
K5K93_RS15830	COG4206	TonB-dependent receptor
K5K93_RS15835	COG4773	Receptor
K5K93_RS15845	COG1522	sequence-specific DNA binding
K5K93_RS15860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5K93_RS15875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5K93_RS15880	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K5K93_RS15900	COG1064	alcohol dehydrogenase
K5K93_RS15905	COG0583	DNA-binding transcription factor activity
K5K93_RS15915	COG1902	pentaerythritol trinitrate reductase activity
K5K93_RS15920	COG0583	DNA-binding transcription factor activity
K5K93_RS15930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K5K93_RS15935	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K5K93_RS15940	COG3706	GGDEF domain
K5K93_RS15940	COG2203	Gaf domain
K5K93_RS15940	COG4251	negative regulation of phosphorylation
K5K93_RS15940	COG5001	Diguanylate cyclase
K5K93_RS15955	COG1307	EDD domain protein, DegV family
K5K93_RS15965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5K93_RS15970	COG1228	amidohydrolase
K5K93_RS15990	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K5K93_RS15995	COG0726	polysaccharide deacetylase
K5K93_RS16015	COG1162	GTPase activity
K5K93_RS16030	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS16035	COG2851	Citrate transporter
K5K93_RS16050	COG0642	Histidine kinase
K5K93_RS16065	COG4191	Histidine kinase
K5K93_RS16075	COG1301	dicarboxylic acid transport
K5K93_RS16115	COG1560	Kdo2-lipid A biosynthetic process
K5K93_RS16120	COG1519	Transferase
K5K93_RS16130	COG1538	Outer membrane efflux protein
K5K93_RS16135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K5K93_RS16170	COG0473	3-isopropylmalate dehydrogenase activity
K5K93_RS16185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5K93_RS16190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5K93_RS16210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K5K93_RS16215	COG0405	Gamma-glutamyltransferase
K5K93_RS16220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5K93_RS16225	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K5K93_RS16235	COG0745	RESPONSE REGULATOR receiver
K5K93_RS16245	COG4771	TonB-dependent receptor
K5K93_RS16255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K5K93_RS16275	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K5K93_RS16295	COG0563	adenylate kinase activity
K5K93_RS16300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5K93_RS16310	COG0671	phosphoesterase, PA-phosphatase related
K5K93_RS16330	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS16345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K93_RS16350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K5K93_RS16360	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K5K93_RS16365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K5K93_RS16375	COG1773	rubredoxin
K5K93_RS16380	COG2912	Transglutaminase-like superfamily
K5K93_RS16390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K5K93_RS16400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5K93_RS16420	COG3079	Belongs to the UPF0149 family
K5K93_RS16425	COG0006	proline dipeptidase activity
K5K93_RS16430	COG0006	proline dipeptidase activity
K5K93_RS16445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5K93_RS16455	COG0346	lactoylglutathione lyase activity
K5K93_RS16460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5K93_RS16465	COG1561	YicC-like family, N-terminal region
K5K93_RS16475	COG1758	RNA polymerase activity
K5K93_RS16480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5K93_RS16490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5K93_RS16500	COG0254	rRNA binding
K5K93_RS16550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K5K93_RS16580	COG0714	Associated with various cellular activities
K5K93_RS16600	COG2304	oxidoreductase activity
K5K93_RS16610	COG1301	dicarboxylic acid transport
K5K93_RS16615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K5K93_RS16675	COG3047	cAMP biosynthetic process
K5K93_RS16680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5K93_RS16695	COG0126	phosphoglycerate kinase activity
K5K93_RS16705	COG0469	pyruvate kinase activity
K5K93_RS16710	COG3588	fructose-bisphosphate aldolase
K5K93_RS16720	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K5K93_RS16730	COG0583	DNA-binding transcription factor activity
K5K93_RS16750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5K93_RS16760	COG1115	amino acid carrier protein
K5K93_RS16765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K93_RS16775	COG1970	mechanosensitive ion channel activity
K5K93_RS16795	COG0471	metal ion transport
K5K93_RS16795	COG3273	potassium ion transport
K5K93_RS16800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5K93_RS16805	COG2022	thiamine diphosphate biosynthetic process
K5K93_RS16815	COG3240	lipase activity
K5K93_RS16815	COG4625	pathogenesis
K5K93_RS16835	COG0189	ligase activity
K5K93_RS16850	COG0745	RESPONSE REGULATOR receiver
K5K93_RS16870	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K5K93_RS16900	COG0045	succinate-CoA ligase (ADP-forming) activity
K5K93_RS16905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5K93_RS16910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5K93_RS16910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K5K93_RS16920	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5K93_RS16925	COG0564	pseudouridine synthase activity
K5K93_RS16940	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
K5K93_RS16945	COG3387	PFAM Glycoside hydrolase 15-related
K5K93_RS16970	COG0028	Belongs to the TPP enzyme family
K5K93_RS16990	COG0542	response to heat
K5K93_RS17000	COG2205	protein histidine kinase activity
K5K93_RS17005	COG0745	RESPONSE REGULATOR receiver
K5K93_RS17020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K5K93_RS17020	COG4651	solute:proton antiporter activity
K5K93_RS17030	COG0488	(ABC) transporter
K5K93_RS17045	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K5K93_RS17060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5K93_RS17080	COG0217	transcriptional regulatory protein
K5K93_RS17085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K5K93_RS17090	COG0632	four-way junction helicase activity
K5K93_RS17100	COG2255	four-way junction helicase activity
K5K93_RS17105	COG0824	Thioesterase
K5K93_RS17125	COG0823	Involved in the tonB-independent uptake of proteins
K5K93_RS17130	COG2885	chlorophyll binding
K5K93_RS17140	COG0602	queuosine metabolic process
K5K93_RS17145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K5K93_RS17235	COG2132	Multicopper oxidase
K5K93_RS17245	COG0514	ATP-dependent DNA helicase (RecQ)
K5K93_RS17250	COG0783	Belongs to the Dps family
K5K93_RS17255	COG1643	Atp-dependent helicase
K5K93_RS17265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5K93_RS17275	COG1442	glycosyl transferase family 8
K5K93_RS17275	COG1216	Glycosyl transferase, family 2
K5K93_RS17280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K93_RS17290	COG1199	ATP-dependent helicase activity
K5K93_RS17305	COG0189	ligase activity
K5K93_RS17320	COG0835	chemotaxis
K5K93_RS17325	COG0840	transmembrane signaling receptor activity
K5K93_RS17330	COG0643	Histidine kinase
K5K93_RS17330	COG2198	Histidine kinase
K5K93_RS17330	COG0784	Response regulator, receiver
K5K93_RS17345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5K93_RS17355	COG0494	nUDIX hydrolase
K5K93_RS17360	COG1218	3'(2'),5'-bisphosphate nucleotidase
K5K93_RS17365	COG3956	TIGRFAM MazG family protein
K5K93_RS17370	COG1742	UPF0060 membrane protein
K5K93_RS17390	COG2271	Major facilitator Superfamily
K5K93_RS17410	COG2186	Transcriptional regulator
K5K93_RS17415	COG0330	HflC and HflK could
K5K93_RS17425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5K93_RS17430	COG0509	glycine decarboxylation via glycine cleavage system
K5K93_RS17475	COG1960	acyl-CoA dehydrogenase activity
K5K93_RS17485	COG1309	transcriptional regulator
K5K93_RS17490	COG4206	TonB-dependent receptor
K5K93_RS17500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5K93_RS17510	COG0463	Glycosyl transferase, family 2
K5K93_RS17520	COG2982	Protein involved in outer membrane biogenesis
K5K93_RS17525	COG1272	protein, Hemolysin III
K5K93_RS17530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5K93_RS17535	COG0739	heme binding
K5K93_RS17540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K5K93_RS17545	COG0626	cystathionine gamma-synthase activity
K5K93_RS17550	COG0460	homoserine dehydrogenase
K5K93_RS17550	COG0527	aspartate kinase activity
K5K93_RS17555	COG0596	Alpha beta hydrolase
K5K93_RS17560	COG1760	l-serine dehydratase
K5K93_RS17575	COG3038	cytochrome b561
K5K93_RS17590	COG2198	Histidine kinase
K5K93_RS17590	COG5002	protein histidine kinase activity
K5K93_RS17590	COG0784	Response regulator, receiver
K5K93_RS17595	COG0477	Major facilitator Superfamily
K5K93_RS17615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5K93_RS17645	COG3829	transcription factor binding
K5K93_RS17665	COG2828	Protein conserved in bacteria
K5K93_RS17670	COG2079	MmgE PrpD family protein
K5K93_RS17675	COG2373	Large extracellular alpha-helical protein
K5K93_RS17680	COG4953	penicillin-binding protein 1C
K5K93_RS17705	COG0604	alcohol dehydrogenase
K5K93_RS17710	COG0330	HflC and HflK could
K5K93_RS17715	COG0330	HflC and HflK could
K5K93_RS17725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5K93_RS17735	COG0739	heme binding
K5K93_RS17740	COG1376	ErfK ybiS ycfS ynhG family protein
K5K93_RS17775	COG0753	catalase activity
K5K93_RS17780	COG2207	Transcriptional regulator
K5K93_RS17780	COG1917	Cupin 2, conserved barrel domain protein
K5K93_RS17785	COG1113	amino acid transport
K5K93_RS17795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K93_RS17795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K93_RS17800	COG2814	Major facilitator Superfamily
K5K93_RS17830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K5K93_RS17835	COG0745	RESPONSE REGULATOR receiver
K5K93_RS17840	COG2205	protein histidine kinase activity
K5K93_RS17860	COG2879	small protein
K5K93_RS17865	COG1966	Carbon starvation protein
K5K93_RS17870	COG1741	Belongs to the pirin family
K5K93_RS17880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5K93_RS17885	COG1741	Belongs to the pirin family
K5K93_RS17890	COG1024	Enoyl-CoA hydratase
K5K93_RS17890	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K93_RS17905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5K93_RS17915	COG0481	GTPase activity
K5K93_RS17920	COG0681	Belongs to the peptidase S26 family
K5K93_RS17935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5K93_RS17940	COG1381	Involved in DNA repair and RecF pathway recombination
K5K93_RS17945	COG0745	RESPONSE REGULATOR receiver
K5K93_RS17950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5K93_RS17960	COG2954	triphosphatase activity
K5K93_RS17965	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K5K93_RS17970	COG1472	Belongs to the glycosyl hydrolase 3 family
K5K93_RS17975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K5K93_RS17980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K5K93_RS17985	COG1278	Cold shock
K5K93_RS17990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5K93_RS18005	COG1201	RNA secondary structure unwinding
K5K93_RS18010	COG1793	dna ligase
K5K93_RS18020	COG1960	acyl-CoA dehydrogenase activity
K5K93_RS18035	COG0183	Belongs to the thiolase family
K5K93_RS18055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K93_RS18065	COG1451	nucleotide metabolic process
K5K93_RS18070	COG3122	Protein conserved in bacteria
K5K93_RS18075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K5K93_RS18090	COG1595	DNA-templated transcription, initiation
K5K93_RS18115	COG0443	Heat shock 70 kDa protein
K5K93_RS18120	COG2824	Alkylphosphonate utilization operon protein PhnA
K5K93_RS18150	COG0392	lysyltransferase activity
K5K93_RS18150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K5K93_RS18155	COG0251	oxidation-reduction process
K5K93_RS18170	COG2878	Part of a membrane complex involved in electron transport
K5K93_RS18180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K93_RS18180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K93_RS18190	COG0346	lactoylglutathione lyase activity
K5K93_RS18195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5K93_RS18205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K5K93_RS18230	COG2203	Gaf domain
K5K93_RS18230	COG4251	negative regulation of phosphorylation
K5K93_RS18230	COG5001	Diguanylate cyclase
K5K93_RS18230	COG3706	GGDEF domain
K5K93_RS18240	COG3118	belongs to the thioredoxin family
K5K93_RS18250	COG0495	leucyl-tRNA aminoacylation
K5K93_RS18265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5K93_RS18275	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5K93_RS18285	COG0657	acetylesterase activity
K5K93_RS18285	COG2755	lipolytic protein G-D-S-L family
K5K93_RS18295	COG4771	TonB-dependent receptor
K5K93_RS18305	COG2968	Membrane
K5K93_RS18325	COG0312	modulator of DNA gyrase
K5K93_RS18330	COG3028	Belongs to the UPF0307 family
K5K93_RS18335	COG0312	modulator of DNA gyrase
K5K93_RS18345	COG0142	geranyltranstransferase activity
K5K93_RS18350	COG1722	exodeoxyribonuclease VII activity
K5K93_RS18370	COG1301	dicarboxylic acid transport
K5K93_RS18410	COG0791	NLP P60 protein
K5K93_RS18415	COG0791	NLP P60 protein
K5K93_RS18420	COG1047	Peptidyl-prolyl cis-trans
K5K93_RS18425	COG2311	Membrane
K5K93_RS18435	COG0697	spore germination
K5K93_RS18480	COG3590	peptidase
K5K93_RS18485	COG4771	TonB-dependent receptor
K5K93_RS18490	COG4771	TonB-dependent receptor
K5K93_RS18500	COG4771	TonB-dependent receptor
K5K93_RS18505	COG4771	TonB-dependent receptor
K5K93_RS18510	COG0489	protein tyrosine kinase activity
K5K93_RS18515	COG0717	Belongs to the dCTP deaminase family
K5K93_RS18530	COG0412	Dienelactone hydrolase
K5K93_RS18540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5K93_RS18550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5K93_RS18555	COG0433	COG0433 Predicted ATPase
K5K93_RS18570	COG0688	phosphatidylethanolamine metabolic process
K5K93_RS18575	COG1999	signal sequence binding
K5K93_RS18580	COG2890	protein-(glutamine-N5) methyltransferase activity
K5K93_RS18585	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5K93_RS18590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K93_RS18595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5K93_RS18610	COG0101	tRNA pseudouridine synthase activity
K5K93_RS18615	COG0135	phosphoribosylanthranilate isomerase activity
K5K93_RS18655	COG0133	tryptophan synthase activity
K5K93_RS18665	COG0159	tryptophan synthase activity
K5K93_RS18670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5K93_RS18675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5K93_RS18680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5K93_RS18685	COG0726	polysaccharide deacetylase
K5K93_RS18690	COG0438	transferase activity, transferring glycosyl groups
K5K93_RS18705	COG0149	triose-phosphate isomerase activity
K5K93_RS18720	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5K93_RS18725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5K93_RS18730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5K93_RS18735	COG0649	NAD binding
K5K93_RS18740	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K5K93_RS18745	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K5K93_RS18755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K5K93_RS18760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5K93_RS18785	COG1007	ATP synthesis coupled electron transport
K5K93_RS18800	COG0779	Required for maturation of 30S ribosomal subunits
K5K93_RS18805	COG0195	Participates in both transcription termination and antitermination
K5K93_RS18810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K5K93_RS18815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K5K93_RS18825	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5K93_RS18830	COG1185	polyribonucleotide nucleotidyltransferase activity
K5K93_RS18875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5K93_RS18880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5K93_RS18890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5K93_RS18895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5K93_RS18905	COG0776	regulation of translation
K5K93_RS18950	COG1794	racemase activity, acting on amino acids and derivatives
K5K93_RS18960	COG1280	lysine exporter protein (LysE YggA)
K5K93_RS18970	COG2076	Multidrug Resistance protein
K5K93_RS19005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5K93_RS19015	COG1960	acyl-CoA dehydrogenase activity
K5K93_RS19040	COG2130	NADP-dependent
K5K93_RS19045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5K93_RS19045	COG2169	Transcriptional regulator
K5K93_RS19050	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS19085	COG1309	transcriptional regulator
K5K93_RS19090	COG4771	TonB-dependent receptor
K5K93_RS19100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K5K93_RS19110	COG1570	exodeoxyribonuclease VII activity
K5K93_RS19115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5K93_RS19120	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K5K93_RS19120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K5K93_RS19125	COG0802	atpase or kinase
K5K93_RS19135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5K93_RS19155	COG1028	Short-chain dehydrogenase reductase Sdr
K5K93_RS19165	COG0501	Belongs to the peptidase M48B family
K5K93_RS19170	COG0483	inositol monophosphate 1-phosphatase activity
K5K93_RS19180	COG5001	Diguanylate cyclase
K5K93_RS19180	COG3300	MHYT domain
K5K93_RS19185	COG1509	lysine 2,3-aminomutase activity
K5K93_RS19190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K93_RS19195	COG0402	S-adenosylhomocysteine deaminase activity
K5K93_RS19200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5K93_RS19220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5K93_RS19240	COG2166	iron-sulfur cluster assembly
K5K93_RS19255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K5K93_RS19260	COG0137	argininosuccinate synthase activity
K5K93_RS19265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K93_RS19270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K5K93_RS19280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K5K93_RS19285	COG0165	Argininosuccinate lyase
K5K93_RS19300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5K93_RS19310	COG1215	transferase activity, transferring glycosyl groups
K5K93_RS19315	COG1649	PFAM Uncharacterised BCR, COG1649
K5K93_RS19315	COG0726	polysaccharide deacetylase
K5K93_RS19345	COG1294	oxidase, subunit
K5K93_RS19355	COG4988	ABC transporter
K5K93_RS19360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5K93_RS19370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K5K93_RS19395	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K5K93_RS19420	COG0436	Aminotransferase
K5K93_RS19445	COG1187	pseudouridine synthase activity
K5K93_RS19450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5K93_RS19455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K5K93_RS19460	COG2350	Protein conserved in bacteria
K5K93_RS19465	COG0271	Belongs to the BolA IbaG family
K5K93_RS19495	COG0395	ABC-type sugar transport system, permease component
K5K93_RS19510	COG1530	ribonuclease E activity
K5K93_RS19520	COG0428	transporter
K5K93_RS19530	COG2154	pterin-4-alpha-carbinolamine dehydratase
K5K93_RS19535	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K5K93_RS19535	COG0316	Belongs to the HesB IscA family
K5K93_RS19555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K5K93_RS19565	COG3104	oligopeptide transport
K5K93_RS19570	COG0705	Rhomboid family
K5K93_RS19590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K5K93_RS19610	COG0339	signal peptide processing
K5K93_RS19615	COG0386	Belongs to the glutathione peroxidase family
K5K93_RS19630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5K93_RS19635	COG1595	DNA-templated transcription, initiation
K5K93_RS19665	COG2839	Protein conserved in bacteria
K5K93_RS19685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K5K93_RS19690	COG0084	hydrolase, TatD family'
K5K93_RS19710	COG0625	glutathione transferase activity
K5K93_RS19730	COG0305	Participates in initiation and elongation during chromosome replication
K5K93_RS19760	COG0567	Dehydrogenase, E1 component
K5K93_RS19770	COG2850	peptidyl-arginine hydroxylation
K5K93_RS19805	COG1131	(ABC) transporter
K5K93_RS19810	COG1725	Transcriptional regulator
K5K93_RS19815	COG0386	Belongs to the glutathione peroxidase family
K5K93_RS19830	COG2900	Belongs to the SlyX family
K5K93_RS19840	COG2755	lipolytic protein G-D-S-L family
K5K93_RS19840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5K93_RS19860	COG1960	acyl-CoA dehydrogenase activity
K5K93_RS19875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5K93_RS19880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5K93_RS19890	COG2902	Dehydrogenase
K5K93_RS19915	COG2925	Exonuclease
K5K93_RS19920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5K93_RS19925	COG3844	kynureninase activity
K5K93_RS19935	COG0288	reversible hydration of carbon dioxide
K5K93_RS19940	COG2808	Putative FMN-binding domain
K5K93_RS19955	COG0017	Asparaginyl-tRNA synthetase
K5K93_RS19960	COG0316	Belongs to the HesB IscA family
K5K93_RS19970	COG0360	Binds together with S18 to 16S ribosomal RNA
K5K93_RS19975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5K93_RS19980	COG0359	binds to the 23S rRNA
K5K93_RS19995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5K93_RS20000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5K93_RS20010	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K5K93_RS20020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5K93_RS20030	COG4993	Dehydrogenase
K5K93_RS20145	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K5K93_RS20160	COG1228	amidohydrolase
K5K93_RS20240	COG1126	abc transporter atp-binding protein
K5K93_RS20310	COG0840	transmembrane signaling receptor activity