locus-tag	class	description
D0Y85_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D0Y85_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0Y85_RS00020	COG0187	DNA topoisomerase II activity
D0Y85_RS00025	COG1266	CAAX protease self-immunity
D0Y85_RS00030	COG0501	Belongs to the peptidase M48B family
D0Y85_RS00105	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D0Y85_RS00115	COG4772	TonB-dependent receptor
D0Y85_RS00150	COG1012	belongs to the aldehyde dehydrogenase family
D0Y85_RS00155	COG3284	Transcriptional regulator
D0Y85_RS00160	COG0800	Aldolase
D0Y85_RS00165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Y85_RS00185	COG2272	Belongs to the type-B carboxylesterase lipase family
D0Y85_RS00200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0Y85_RS00215	COG3507	Belongs to the glycosyl hydrolase 43 family
D0Y85_RS00220	COG1609	Transcriptional regulator
D0Y85_RS00230	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS00235	COG2755	lipolytic protein G-D-S-L family
D0Y85_RS00245	COG3186	Phenylalanine-4-hydroxylase
D0Y85_RS00250	COG1522	sequence-specific DNA binding
D0Y85_RS00260	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0Y85_RS00270	COG4771	TonB-dependent receptor
D0Y85_RS00290	COG1122	ATPase activity
D0Y85_RS00305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0Y85_RS00315	COG2815	serine threonine protein kinase
D0Y85_RS00315	COG0515	serine threonine protein kinase
D0Y85_RS00320	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D0Y85_RS00330	COG1435	thymidine kinase activity
D0Y85_RS00335	COG0210	DNA helicase
D0Y85_RS00355	COG3132	Protein of unknown function, DUF480
D0Y85_RS00360	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D0Y85_RS00365	COG0284	orotidine-5'-phosphate decarboxylase activity
D0Y85_RS00370	COG5640	endopeptidase activity
D0Y85_RS00380	COG2937	Belongs to the GPAT DAPAT family
D0Y85_RS00395	COG0037	tRNA processing
D0Y85_RS00400	COG2974	May be involved in recombination
D0Y85_RS00410	COG1803	Methylglyoxal synthase
D0Y85_RS00415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y85_RS00415	COG2205	protein histidine kinase activity
D0Y85_RS00420	COG0493	'glutamate synthase
D0Y85_RS00425	COG0069	glutamate synthase activity
D0Y85_RS00425	COG0067	glutamate synthase
D0Y85_RS00425	COG0070	glutamate synthase
D0Y85_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS00450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0Y85_RS00475	COG1111	helicase
D0Y85_RS00475	COG1205	dead DEAH box helicase
D0Y85_RS00515	COG0714	Associated with various cellular activities
D0Y85_RS00535	COG0312	modulator of DNA gyrase
D0Y85_RS00555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0Y85_RS00575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0Y85_RS00610	COG1968	undecaprenyl-diphosphatase activity
D0Y85_RS00615	COG0174	glutamine synthetase
D0Y85_RS00620	COG0347	Belongs to the P(II) protein family
D0Y85_RS00625	COG0004	ammonium transporteR
D0Y85_RS00635	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D0Y85_RS00660	COG3852	Histidine kinase
D0Y85_RS00665	COG2204	response regulator
D0Y85_RS00670	COG2032	superoxide dismutase activity
D0Y85_RS00675	COG2032	superoxide dismutase activity
D0Y85_RS00685	COG0183	Belongs to the thiolase family
D0Y85_RS00720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D0Y85_RS00725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D0Y85_RS00760	COG1733	regulation of RNA biosynthetic process
D0Y85_RS00765	COG1309	transcriptional regulator
D0Y85_RS00770	COG0604	alcohol dehydrogenase
D0Y85_RS00785	COG1309	transcriptional regulator
D0Y85_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS00800	COG2207	Transcriptional regulator
D0Y85_RS00855	COG0859	PFAM glycosyl transferase family 9
D0Y85_RS00900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0Y85_RS00905	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0Y85_RS00910	COG4786	Flagellar basal body rod
D0Y85_RS00915	COG4786	Flagellar basal body rod
D0Y85_RS00925	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0Y85_RS00930	COG1706	bacterial-type flagellum-dependent cell motility
D0Y85_RS00945	COG1677	Flagellar hook-basal body complex protein FliE
D0Y85_RS00965	COG1157	protein secretion by the type III secretion system
D0Y85_RS00980	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0Y85_RS01060	COG2837	iron assimilation
D0Y85_RS01090	COG2197	response regulator
D0Y85_RS01095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y85_RS01095	COG2205	protein histidine kinase activity
D0Y85_RS01100	COG3474	cytochrome
D0Y85_RS01110	COG1960	acyl-CoA dehydrogenase activity
D0Y85_RS01115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0Y85_RS01125	COG0612	Peptidase, M16
D0Y85_RS01135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0Y85_RS01140	COG0596	Alpha beta hydrolase
D0Y85_RS01150	COG0318	PFAM AMP-dependent synthetase and ligase
D0Y85_RS01155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0Y85_RS01165	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0Y85_RS01175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0Y85_RS01185	COG0564	pseudouridine synthase activity
D0Y85_RS01205	COG0339	signal peptide processing
D0Y85_RS01225	COG0681	Belongs to the peptidase S26 family
D0Y85_RS01230	COG2814	Major facilitator Superfamily
D0Y85_RS01235	COG0583	DNA-binding transcription factor activity
D0Y85_RS01240	COG0583	DNA-binding transcription factor activity
D0Y85_RS01245	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0Y85_RS01250	COG2224	Isocitrate lyase
D0Y85_RS01280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0Y85_RS01285	COG1960	acyl-CoA dehydrogenase activity
D0Y85_RS01310	COG0697	spore germination
D0Y85_RS01320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0Y85_RS01330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0Y85_RS01335	COG1280	lysine exporter protein (LysE YggA)
D0Y85_RS01340	COG1607	acyl-coa hydrolase
D0Y85_RS01350	COG1902	pentaerythritol trinitrate reductase activity
D0Y85_RS01375	COG1335	isochorismatase
D0Y85_RS01380	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D0Y85_RS01385	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0Y85_RS01395	COG3800	Transcriptional regulator
D0Y85_RS01395	COG1396	sequence-specific DNA binding
D0Y85_RS01405	COG1960	acyl-CoA dehydrogenase activity
D0Y85_RS01410	COG1024	Enoyl-CoA hydratase
D0Y85_RS01415	COG1024	Enoyl-CoA hydratase
D0Y85_RS01425	COG1764	response to oxidative stress
D0Y85_RS01435	COG0659	secondary active sulfate transmembrane transporter activity
D0Y85_RS01445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0Y85_RS01475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D0Y85_RS01475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D0Y85_RS01480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D0Y85_RS01540	COG3237	CsbD-like
D0Y85_RS01550	COG0180	Tryptophanyl-tRNA synthetase
D0Y85_RS01570	COG0477	Major facilitator Superfamily
D0Y85_RS01575	COG0697	spore germination
D0Y85_RS01590	COG1136	(ABC) transporter
D0Y85_RS01590	COG0577	efflux transmembrane transporter activity
D0Y85_RS01600	COG1136	(ABC) transporter
D0Y85_RS01605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y85_RS01615	COG4585	Histidine kinase
D0Y85_RS01620	COG2197	response regulator
D0Y85_RS01630	COG3038	cytochrome b561
D0Y85_RS01640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0Y85_RS01650	COG0628	permease
D0Y85_RS01670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Y85_RS01685	COG5507	3-demethylubiquinone-9 3-methyltransferase
D0Y85_RS01695	COG2771	luxR family
D0Y85_RS01695	COG2200	EAL domain
D0Y85_RS01710	COG2814	Major facilitator Superfamily
D0Y85_RS01715	COG0583	DNA-binding transcription factor activity
D0Y85_RS01720	COG4807	Protein conserved in bacteria
D0Y85_RS01730	COG4221	oxidoreductase activity
D0Y85_RS01740	COG0018	arginyl-trna synthetase
D0Y85_RS01745	COG2003	Belongs to the UPF0758 family
D0Y85_RS01750	COG2197	response regulator
D0Y85_RS01755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0Y85_RS01760	COG0756	dUTP diphosphatase activity
D0Y85_RS01775	COG2205	protein histidine kinase activity
D0Y85_RS01785	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D0Y85_RS01790	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D0Y85_RS01805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D0Y85_RS01810	COG0708	Exodeoxyribonuclease III
D0Y85_RS01815	COG2223	nitrite transmembrane transporter activity
D0Y85_RS01830	COG0739	heme binding
D0Y85_RS01835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0Y85_RS01895	COG2234	aminopeptidase activity
D0Y85_RS01905	COG4942	peptidase
D0Y85_RS01910	COG0793	Belongs to the peptidase S41A family
D0Y85_RS01920	COG2067	long-chain fatty acid transport protein
D0Y85_RS01945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0Y85_RS01950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0Y85_RS01990	COG0109	protoheme IX farnesyltransferase activity
D0Y85_RS02005	COG0358	DNA primase activity
D0Y85_RS02010	COG1295	ribonuclease BN
D0Y85_RS02015	COG1610	YqeY-like protein
D0Y85_RS02025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0Y85_RS02035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0Y85_RS02040	COG0668	transmembrane transport
D0Y85_RS02055	COG2133	pyrroloquinoline quinone binding
D0Y85_RS02060	COG4682	membrane
D0Y85_RS02070	COG0531	amino acid
D0Y85_RS02080	COG1737	Transcriptional regulator
D0Y85_RS02085	COG4948	Mandelate Racemase Muconate Lactonizing
D0Y85_RS02135	COG5383	Protein conserved in bacteria
D0Y85_RS02145	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D0Y85_RS02155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0Y85_RS02175	COG0778	Nitroreductase
D0Y85_RS02180	COG2353	YceI-like domain
D0Y85_RS02195	COG2375	cellular response to nickel ion
D0Y85_RS02280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0Y85_RS02310	COG2267	carboxylic ester hydrolase activity
D0Y85_RS02330	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D0Y85_RS02380	COG0488	(ABC) transporter
D0Y85_RS02385	COG0583	DNA-binding transcription factor activity
D0Y85_RS02395	COG2814	Major facilitator Superfamily
D0Y85_RS02400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0Y85_RS02405	COG1113	amino acid transport
D0Y85_RS02410	COG0741	lytic transglycosylase activity
D0Y85_RS02435	COG2764	glyoxalase bleomycin resistance protein dioxygenase
D0Y85_RS02445	COG5507	3-demethylubiquinone-9 3-methyltransferase
D0Y85_RS02450	COG4941	Belongs to the sigma-70 factor family
D0Y85_RS02460	COG3275	phosphorelay sensor kinase activity
D0Y85_RS02465	COG3279	Response regulator of the LytR AlgR family
D0Y85_RS02485	COG3590	peptidase
D0Y85_RS02490	COG5001	Diguanylate cyclase
D0Y85_RS02505	COG3384	dioxygenase
D0Y85_RS02510	COG0025	NhaP-type Na H and K H
D0Y85_RS02535	COG1360	Flagellar Motor Protein
D0Y85_RS02565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Y85_RS02580	COG2205	protein histidine kinase activity
D0Y85_RS02595	COG2813	Specifically methylates the guanine in position
D0Y85_RS02600	COG1187	pseudouridine synthase activity
D0Y85_RS02605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y85_RS02615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0Y85_RS02620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0Y85_RS02635	COG0583	DNA-binding transcription factor activity
D0Y85_RS02640	COG2226	methyltransferase
D0Y85_RS02665	COG1956	GAF domain-containing protein
D0Y85_RS02670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D0Y85_RS02675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Y85_RS02680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Y85_RS02685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Y85_RS02685	COG0785	Cytochrome C biogenesis protein
D0Y85_RS02690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Y85_RS02695	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS02700	COG5002	protein histidine kinase activity
D0Y85_RS02705	COG2205	protein histidine kinase activity
D0Y85_RS02710	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS02720	COG0720	synthase
D0Y85_RS02735	COG0513	Belongs to the DEAD box helicase family
D0Y85_RS02745	COG0625	glutathione transferase activity
D0Y85_RS02750	COG1573	uracil-dna glycosylase
D0Y85_RS02785	COG0626	cystathionine gamma-synthase activity
D0Y85_RS02800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0Y85_RS02815	COG1215	transferase activity, transferring glycosyl groups
D0Y85_RS02820	COG0463	Glycosyl transferase, family 2
D0Y85_RS02865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0Y85_RS02870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0Y85_RS02900	COG1127	ABC transporter
D0Y85_RS02905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0Y85_RS02920	COG0442	prolyl-tRNA aminoacylation
D0Y85_RS02935	COG1183	phosphatidylcholine synthase activity
D0Y85_RS02955	COG0525	valine-tRNA ligase activity
D0Y85_RS02970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0Y85_RS02980	COG0795	lipopolysaccharide-transporting ATPase activity
D0Y85_RS02990	COG4974	Belongs to the 'phage' integrase family
D0Y85_RS03005	COG0047	phosphoribosylformylglycinamidine synthase activity
D0Y85_RS03005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0Y85_RS03010	COG5295	Hep Hag repeat protein
D0Y85_RS03015	COG1404	Belongs to the peptidase S8 family
D0Y85_RS03020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0Y85_RS03025	COG1459	type II secretion system
D0Y85_RS03030	COG2165	general secretion pathway protein
D0Y85_RS03035	COG4970	Tfp pilus assembly protein FimT
D0Y85_RS03040	COG2165	general secretion pathway protein
D0Y85_RS03045	COG4795	General secretion pathway protein
D0Y85_RS03050	COG3156	type II secretion system protein K
D0Y85_RS03055	COG3166	PFAM Fimbrial assembly family protein
D0Y85_RS03070	COG1450	Type ii and iii secretion system protein
D0Y85_RS03100	COG2194	sulfuric ester hydrolase activity
D0Y85_RS03115	COG1215	transferase activity, transferring glycosyl groups
D0Y85_RS03120	COG1215	transferase activity, transferring glycosyl groups
D0Y85_RS03125	COG0457	Tetratricopeptide repeat
D0Y85_RS03125	COG3118	belongs to the thioredoxin family
D0Y85_RS03130	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D0Y85_RS03135	COG2252	PERMEase
D0Y85_RS03145	COG0488	(ABC) transporter
D0Y85_RS03155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0Y85_RS03170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0Y85_RS03175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Y85_RS03175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0Y85_RS03205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D0Y85_RS03210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0Y85_RS03240	COG2755	lipolytic protein G-D-S-L family
D0Y85_RS03240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0Y85_RS03245	COG0277	FAD linked oxidase domain protein
D0Y85_RS03250	COG1988	membrane-bound metal-dependent
D0Y85_RS03285	COG2001	Belongs to the MraZ family
D0Y85_RS03290	COG0275	rRNA processing
D0Y85_RS03295	COG3116	cell division
D0Y85_RS03310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0Y85_RS03330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0Y85_RS03335	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0Y85_RS03340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0Y85_RS03350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0Y85_RS03355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D0Y85_RS03365	COG0739	heme binding
D0Y85_RS03370	COG0653	protein targeting
D0Y85_RS03375	COG0494	nUDIX hydrolase
D0Y85_RS03385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0Y85_RS03390	COG2267	carboxylic ester hydrolase activity
D0Y85_RS03395	COG3275	phosphorelay sensor kinase activity
D0Y85_RS03405	COG0402	S-adenosylhomocysteine deaminase activity
D0Y85_RS03425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0Y85_RS03430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D0Y85_RS03445	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0Y85_RS03450	COG1607	acyl-coa hydrolase
D0Y85_RS03455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0Y85_RS03475	COG4106	trans-aconitate 2-methyltransferase activity
D0Y85_RS03480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0Y85_RS03495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0Y85_RS03500	COG0667	Aldo Keto reductase
D0Y85_RS03510	COG4771	TonB-dependent receptor
D0Y85_RS03535	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D0Y85_RS03540	COG4181	ATPase activity
D0Y85_RS03555	COG0642	Histidine kinase
D0Y85_RS03565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0Y85_RS03570	COG0861	Integral membrane protein TerC family
D0Y85_RS03575	COG2814	Major facilitator Superfamily
D0Y85_RS03580	COG1704	LemA family
D0Y85_RS03595	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D0Y85_RS03600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D0Y85_RS03610	COG3738	Protein conserved in bacteria
D0Y85_RS03615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0Y85_RS03620	COG2967	ApaG domain
D0Y85_RS03630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D0Y85_RS03640	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0Y85_RS03650	COG2096	Adenosyltransferase
D0Y85_RS03660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Y85_RS03665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Y85_RS03675	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D0Y85_RS03695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0Y85_RS03705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0Y85_RS03715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Y85_RS03720	COG0583	DNA-binding transcription factor activity
D0Y85_RS03725	COG3634	alkyl hydroperoxide reductase activity
D0Y85_RS03750	COG0583	DNA-binding transcription factor activity
D0Y85_RS03790	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D0Y85_RS03815	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D0Y85_RS03830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0Y85_RS03835	COG1404	Belongs to the peptidase S8 family
D0Y85_RS03855	COG1295	ribonuclease BN
D0Y85_RS03860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Y85_RS03875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D0Y85_RS03880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D0Y85_RS03895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D0Y85_RS03905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0Y85_RS03915	COG0193	aminoacyl-tRNA hydrolase activity
D0Y85_RS03920	COG0012	GTP binding
D0Y85_RS03925	COG2197	response regulator
D0Y85_RS03930	COG2205	protein histidine kinase activity
D0Y85_RS03930	COG0784	Response regulator, receiver
D0Y85_RS03940	COG0784	Response regulator, receiver
D0Y85_RS03940	COG2205	protein histidine kinase activity
D0Y85_RS03945	COG4206	TonB-dependent receptor
D0Y85_RS03950	COG4242	Belongs to the peptidase S51 family
D0Y85_RS03975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0Y85_RS03990	COG0250	Participates in transcription elongation, termination and antitermination
D0Y85_RS03995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D0Y85_RS04000	COG0081	regulation of translation
D0Y85_RS04010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0Y85_RS04015	COG0222	ribosome binding
D0Y85_RS04020	COG0085	RNA polymerase activity
D0Y85_RS04025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D0Y85_RS04040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0Y85_RS04045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0Y85_RS04050	COG0051	transcription antitermination factor activity, RNA binding
D0Y85_RS04055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D0Y85_RS04060	COG0088	Forms part of the polypeptide exit tunnel
D0Y85_RS04065	COG0089	rRNA binding
D0Y85_RS04070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D0Y85_RS04075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0Y85_RS04080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0Y85_RS04085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D0Y85_RS04090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D0Y85_RS04095	COG0255	Belongs to the universal ribosomal protein uL29 family
D0Y85_RS04100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D0Y85_RS04105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D0Y85_RS04110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D0Y85_RS04115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0Y85_RS04120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0Y85_RS04125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D0Y85_RS04130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D0Y85_RS04135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D0Y85_RS04140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D0Y85_RS04145	COG1841	ribosomal large subunit assembly
D0Y85_RS04155	COG0201	protein transport
D0Y85_RS04160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0Y85_RS04165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0Y85_RS04170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D0Y85_RS04175	COG0202	RNA polymerase activity
D0Y85_RS04180	COG0203	ribosomal protein L17
D0Y85_RS04195	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D0Y85_RS04205	COG0154	amidase activity
D0Y85_RS04220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0Y85_RS04225	COG0039	L-malate dehydrogenase activity
D0Y85_RS04235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0Y85_RS04250	COG0625	glutathione transferase activity
D0Y85_RS04260	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0Y85_RS04260	COG1902	pentaerythritol trinitrate reductase activity
D0Y85_RS04265	COG2364	Membrane
D0Y85_RS04270	COG0604	alcohol dehydrogenase
D0Y85_RS04285	COG1187	pseudouridine synthase activity
D0Y85_RS04305	COG1063	alcohol dehydrogenase
D0Y85_RS04315	COG0406	alpha-ribazole phosphatase activity
D0Y85_RS04320	COG0285	dihydrofolate synthase activity
D0Y85_RS04340	COG2833	Protein of unknown function (DUF455)
D0Y85_RS04350	COG3291	Pkd domain containing protein
D0Y85_RS04355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0Y85_RS04360	COG0671	phosphoesterase, PA-phosphatase related
D0Y85_RS04365	COG0438	transferase activity, transferring glycosyl groups
D0Y85_RS04370	COG4206	TonB-dependent receptor
D0Y85_RS04375	COG0248	Ppx GppA phosphatase
D0Y85_RS04380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D0Y85_RS04395	COG4783	chaperone-mediated protein folding
D0Y85_RS04410	COG0473	3-isopropylmalate dehydrogenase activity
D0Y85_RS04480	COG0544	peptidyl-prolyl cis-trans isomerase activity
D0Y85_RS04490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0Y85_RS04525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0Y85_RS04530	COG1388	LysM domain
D0Y85_RS04530	COG3942	CHAP domain
D0Y85_RS04535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Y85_RS04550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0Y85_RS04555	COG0631	protein serine/threonine phosphatase activity
D0Y85_RS04570	COG0859	PFAM glycosyl transferase family 9
D0Y85_RS04575	COG3642	lipopolysaccharide core region biosynthetic process
D0Y85_RS04580	COG1234	tRNA 3'-trailer cleavage
D0Y85_RS04595	COG2076	Multidrug Resistance protein
D0Y85_RS04605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0Y85_RS04610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0Y85_RS04620	COG0537	adenosine 5'-monophosphoramidase activity
D0Y85_RS04640	COG0714	Associated with various cellular activities
D0Y85_RS04655	COG1399	metal-binding, possibly nucleic acid-binding protein
D0Y85_RS04660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D0Y85_RS04665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0Y85_RS04675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D0Y85_RS04690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Y85_RS04695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0Y85_RS04700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0Y85_RS04705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0Y85_RS04750	COG0583	DNA-binding transcription factor activity
D0Y85_RS04755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Y85_RS04760	COG0697	spore germination
D0Y85_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS04770	COG0583	DNA-binding transcription factor activity
D0Y85_RS04775	COG0583	DNA-binding transcription factor activity
D0Y85_RS04810	COG0583	DNA-binding transcription factor activity
D0Y85_RS04845	COG0667	Aldo Keto reductase
D0Y85_RS04870	COG2818	Glycosylase
D0Y85_RS04875	COG1678	Uncharacterized ACR, COG1678
D0Y85_RS04880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0Y85_RS04885	COG0540	Belongs to the ATCase OTCase family
D0Y85_RS04905	COG2239	Acts as a magnesium transporter
D0Y85_RS04910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0Y85_RS04925	COG1660	Displays ATPase and GTPase activities
D0Y85_RS04930	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D0Y85_RS04935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0Y85_RS04940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0Y85_RS04950	COG1137	ATPase activity
D0Y85_RS04965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D0Y85_RS04980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0Y85_RS05000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0Y85_RS05020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0Y85_RS05030	COG0628	permease
D0Y85_RS05040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D0Y85_RS05050	COG2261	transglycosylase associated protein
D0Y85_RS05080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0Y85_RS05085	COG1477	protein flavinylation
D0Y85_RS05105	COG4771	TonB-dependent receptor
D0Y85_RS05115	COG3128	pkhd-type hydroxylase
D0Y85_RS05125	COG4774	siderophore transport
D0Y85_RS05135	COG2146	nitrite reductase [NAD(P)H] activity
D0Y85_RS05155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0Y85_RS05160	COG0719	Fe-S assembly protein
D0Y85_RS05165	COG0396	ATPase activity
D0Y85_RS05170	COG0719	Fe-S assembly protein
D0Y85_RS05175	COG1959	2 iron, 2 sulfur cluster binding
D0Y85_RS05185	COG0693	protein deglycase activity
D0Y85_RS05210	COG1764	response to oxidative stress
D0Y85_RS05220	COG0384	phenazine biosynthesis protein PhzF
D0Y85_RS05225	COG0527	aspartate kinase activity
D0Y85_RS05235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0Y85_RS05255	COG0142	geranyltranstransferase activity
D0Y85_RS05260	COG0366	Alpha amylase catalytic
D0Y85_RS05270	COG1082	Xylose isomerase domain protein TIM barrel
D0Y85_RS05280	COG2211	Major facilitator Superfamily
D0Y85_RS05280	COG2190	(PTS) system
D0Y85_RS05305	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D0Y85_RS05310	COG4191	Histidine kinase
D0Y85_RS05310	COG0784	Response regulator, receiver
D0Y85_RS05320	COG0629	single-stranded DNA binding
D0Y85_RS05360	COG0673	inositol 2-dehydrogenase activity
D0Y85_RS05365	COG2211	Major facilitator Superfamily
D0Y85_RS05375	COG1609	Transcriptional regulator
D0Y85_RS05380	COG2259	Doxx family
D0Y85_RS05385	COG0798	PFAM Bile acid sodium symporter
D0Y85_RS05390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Y85_RS05400	COG0431	NADPH-dependent FMN reductase
D0Y85_RS05430	COG0640	Transcriptional regulator
D0Y85_RS05440	COG3655	Transcriptional regulator
D0Y85_RS05445	COG1253	flavin adenine dinucleotide binding
D0Y85_RS05450	COG1408	metallophosphoesterase
D0Y85_RS05480	COG2259	Doxx family
D0Y85_RS05505	COG0477	Major facilitator Superfamily
D0Y85_RS05520	COG1802	Transcriptional regulator
D0Y85_RS05555	COG3052	prosthetic group binding
D0Y85_RS05570	COG0579	oxidoreductase
D0Y85_RS05595	COG0454	-acetyltransferase
D0Y85_RS05595	COG0456	acetyltransferase
D0Y85_RS05625	COG3104	oligopeptide transport
D0Y85_RS05640	COG1297	OPT oligopeptide transporter protein
D0Y85_RS05645	COG1506	peptidase
D0Y85_RS05645	COG0823	Involved in the tonB-independent uptake of proteins
D0Y85_RS05665	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D0Y85_RS05670	COG2894	cell division
D0Y85_RS05685	COG4585	Histidine kinase
D0Y85_RS05690	COG2197	response regulator
D0Y85_RS05710	COG1073	alpha beta
D0Y85_RS05730	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D0Y85_RS05740	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D0Y85_RS05750	COG1595	DNA-templated transcription, initiation
D0Y85_RS05760	COG1946	Acyl-CoA thioesterase
D0Y85_RS05780	COG0824	Thioesterase
D0Y85_RS05785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0Y85_RS05790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0Y85_RS05795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D0Y85_RS05800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D0Y85_RS05805	COG0268	Binds directly to 16S ribosomal RNA
D0Y85_RS05810	COG0728	peptidoglycan biosynthetic process
D0Y85_RS05815	COG0196	riboflavin kinase activity
D0Y85_RS05820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0Y85_RS05830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0Y85_RS05850	COG4206	TonB-dependent receptor
D0Y85_RS05900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0Y85_RS05905	COG1845	cytochrome c oxidase, subunit III
D0Y85_RS05910	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0Y85_RS05925	COG0326	Molecular chaperone. Has ATPase activity
D0Y85_RS05945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0Y85_RS05970	COG0228	four-way junction DNA binding
D0Y85_RS05975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D0Y85_RS05980	COG0336	Belongs to the RNA methyltransferase TrmD family
D0Y85_RS05985	COG0335	large ribosomal subunit rRNA binding
D0Y85_RS06005	COG0534	Mate efflux family protein
D0Y85_RS06020	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D0Y85_RS06045	COG0840	transmembrane signaling receptor activity
D0Y85_RS06070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y85_RS06090	COG0024	Methionine aminopeptidase
D0Y85_RS06115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0Y85_RS06140	COG1647	Serine aminopeptidase, S33
D0Y85_RS06165	COG2814	Major facilitator Superfamily
D0Y85_RS06170	COG3706	GGDEF domain
D0Y85_RS06185	COG1515	deoxyribonuclease V activity
D0Y85_RS06190	COG0588	phosphoglycerate mutase activity
D0Y85_RS06195	COG3590	peptidase
D0Y85_RS06215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0Y85_RS06225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D0Y85_RS06230	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS06235	COG2205	protein histidine kinase activity
D0Y85_RS06240	COG4452	Inner membrane protein CreD
D0Y85_RS06255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0Y85_RS06260	COG0735	belongs to the Fur family
D0Y85_RS06340	COG5002	protein histidine kinase activity
D0Y85_RS06340	COG5001	Diguanylate cyclase
D0Y85_RS06350	COG1187	pseudouridine synthase activity
D0Y85_RS06385	COG1132	(ABC) transporter
D0Y85_RS06445	COG1981	membrane
D0Y85_RS06450	COG0825	malonyl-CoA metabolic process
D0Y85_RS06475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0Y85_RS06480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0Y85_RS06485	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0Y85_RS06490	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Y85_RS06495	COG0750	zinc metalloprotease
D0Y85_RS06500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0Y85_RS06505	COG0575	Belongs to the CDS family
D0Y85_RS06510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0Y85_RS06515	COG0233	cytoplasmic translational termination
D0Y85_RS06520	COG0528	UMP kinase activity
D0Y85_RS06530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D0Y85_RS06535	COG0052	Belongs to the universal ribosomal protein uS2 family
D0Y85_RS06555	COG3188	usher protein
D0Y85_RS06570	COG0024	Methionine aminopeptidase
D0Y85_RS06575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D0Y85_RS06585	COG1393	Belongs to the ArsC family
D0Y85_RS06590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Y85_RS06600	COG0367	asparagine synthase
D0Y85_RS06605	COG0475	glutathione-regulated potassium exporter activity
D0Y85_RS06640	COG1566	PFAM secretion protein HlyD family protein
D0Y85_RS06645	COG2814	Major facilitator Superfamily
D0Y85_RS06655	COG0583	DNA-binding transcription factor activity
D0Y85_RS06675	COG0557	exoribonuclease II activity
D0Y85_RS06685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Y85_RS06690	COG1538	Outer membrane efflux protein
D0Y85_RS06695	COG0577	efflux transmembrane transporter activity
D0Y85_RS06695	COG1136	(ABC) transporter
D0Y85_RS06700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y85_RS06720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0Y85_RS06725	COG2259	Doxx family
D0Y85_RS06735	COG3220	belongs to the UPF0276 family
D0Y85_RS06745	COG0704	Plays a role in the regulation of phosphate uptake
D0Y85_RS06755	COG0581	inorganic phosphate transmembrane transporter activity
D0Y85_RS06760	COG0573	inorganic phosphate transmembrane transporter activity
D0Y85_RS06765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0Y85_RS06770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0Y85_RS06785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0Y85_RS06795	COG1024	Enoyl-CoA hydratase
D0Y85_RS06825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D0Y85_RS06825	COG0116	Belongs to the methyltransferase superfamily
D0Y85_RS06850	COG2733	membrane
D0Y85_RS06860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0Y85_RS06865	COG1012	belongs to the aldehyde dehydrogenase family
D0Y85_RS06870	COG0477	Major facilitator Superfamily
D0Y85_RS06875	COG2703	oxygen carrier activity
D0Y85_RS06900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Y85_RS06905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D0Y85_RS06910	COG0174	glutamine synthetase
D0Y85_RS06925	COG3842	ATPase activity
D0Y85_RS06930	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0Y85_RS06935	COG1177	transmembrane transport
D0Y85_RS06940	COG1012	belongs to the aldehyde dehydrogenase family
D0Y85_RS06955	COG4535	Mg2 and Co2 transporter CorC
D0Y85_RS06970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D0Y85_RS06980	COG1702	phosphate starvation-inducible protein PhoH
D0Y85_RS06985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y85_RS06990	COG1131	(ABC) transporter
D0Y85_RS06995	COG0842	Transport permease protein
D0Y85_RS07000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0Y85_RS07015	COG0741	lytic transglycosylase activity
D0Y85_RS07020	COG0723	plastoquinol--plastocyanin reductase activity
D0Y85_RS07025	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0Y85_RS07030	COG2857	Cytochrome c1
D0Y85_RS07035	COG0625	glutathione transferase activity
D0Y85_RS07040	COG2969	positive regulation of protein catabolic process
D0Y85_RS07075	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0Y85_RS07080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0Y85_RS07085	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS07095	COG1611	Belongs to the LOG family
D0Y85_RS07100	COG4969	Belongs to the N-Me-Phe pilin family
D0Y85_RS07140	COG0556	nucleotide-excision repair
D0Y85_RS07180	COG3713	MltA-interacting MipA family protein
D0Y85_RS07190	COG2205	protein histidine kinase activity
D0Y85_RS07195	COG0658	competence protein
D0Y85_RS07195	COG2333	competence protein COMEC
D0Y85_RS07200	COG0811	peptide transport
D0Y85_RS07215	COG1663	tetraacyldisaccharide 4'-kinase activity
D0Y85_RS07220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D0Y85_RS07225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Y85_RS07235	COG0322	excinuclease ABC activity
D0Y85_RS07275	COG0577	efflux transmembrane transporter activity
D0Y85_RS07275	COG1136	(ABC) transporter
D0Y85_RS07310	COG1397	ADP-ribosylglycohydrolase
D0Y85_RS07315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0Y85_RS07335	COG1917	Cupin 2, conserved barrel domain protein
D0Y85_RS07335	COG4977	sequence-specific DNA binding
D0Y85_RS07340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0Y85_RS07375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0Y85_RS07655	COG0758	DNA mediated transformation
D0Y85_RS07655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0Y85_RS07685	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D0Y85_RS07690	COG0069	glutamate synthase activity
D0Y85_RS07715	COG1054	Belongs to the UPF0176 family
D0Y85_RS07720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Y85_RS07735	COG1253	flavin adenine dinucleotide binding
D0Y85_RS07755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0Y85_RS07770	COG0504	CTP synthase activity
D0Y85_RS07790	COG0148	phosphopyruvate hydratase activity
D0Y85_RS07795	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D0Y85_RS07800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0Y85_RS07805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D0Y85_RS07815	COG2840	Smr protein MutS2
D0Y85_RS07820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D0Y85_RS07825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D0Y85_RS07845	COG1534	Rna-binding protein
D0Y85_RS07850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D0Y85_RS07855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0Y85_RS07875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0Y85_RS07880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D0Y85_RS07885	COG1923	regulation of RNA biosynthetic process
D0Y85_RS07890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0Y85_RS07895	COG1546	Belongs to the CinA family
D0Y85_RS07900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0Y85_RS07905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0Y85_RS07910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0Y85_RS07915	COG2137	regulation of response to DNA damage stimulus
D0Y85_RS07920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0Y85_RS07925	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D0Y85_RS07935	COG1201	RNA secondary structure unwinding
D0Y85_RS07945	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0Y85_RS07950	COG1595	DNA-templated transcription, initiation
D0Y85_RS07965	COG3540	Alkaline phosphatase
D0Y85_RS07980	COG3258	Cytochrome c
D0Y85_RS07995	COG2223	nitrite transmembrane transporter activity
D0Y85_RS08005	COG1741	Belongs to the pirin family
D0Y85_RS08010	COG0583	DNA-binding transcription factor activity
D0Y85_RS08035	COG0351	phosphomethylpyrimidine kinase
D0Y85_RS08035	COG0352	thiamine-phosphate diphosphorylase activity
D0Y85_RS08050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D0Y85_RS08055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0Y85_RS08065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0Y85_RS08075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0Y85_RS08080	COG0477	Major facilitator Superfamily
D0Y85_RS08090	COG0617	tRNA 3'-terminal CCA addition
D0Y85_RS08100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D0Y85_RS08105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D0Y85_RS08115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D0Y85_RS08120	COG0166	Belongs to the GPI family
D0Y85_RS08125	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D0Y85_RS08135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D0Y85_RS08140	COG0671	phosphoesterase, PA-phosphatase related
D0Y85_RS08150	COG0800	Aldolase
D0Y85_RS08155	COG0129	dihydroxy-acid dehydratase activity
D0Y85_RS08160	COG0363	glucosamine-6-phosphate deaminase activity
D0Y85_RS08165	COG0837	glucose binding
D0Y85_RS08170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0Y85_RS08175	COG3842	ATPase activity
D0Y85_RS08190	COG2009	succinate dehydrogenase
D0Y85_RS08195	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D0Y85_RS08205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0Y85_RS08220	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0Y85_RS08235	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D0Y85_RS08245	COG0552	protein localization to endoplasmic reticulum
D0Y85_RS08265	COG0742	ribosomal rna small subunit methyltransferase
D0Y85_RS08270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0Y85_RS08280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0Y85_RS08285	COG0405	Gamma-glutamyltransferase
D0Y85_RS08290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Y85_RS08300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0Y85_RS08330	COG0415	Belongs to the DNA photolyase family
D0Y85_RS08335	COG2885	chlorophyll binding
D0Y85_RS08340	COG0583	DNA-binding transcription factor activity
D0Y85_RS08430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D0Y85_RS08440	COG2914	Belongs to the UPF0125 (RnfH) family
D0Y85_RS08445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Y85_RS08460	COG0583	DNA-binding transcription factor activity
D0Y85_RS08465	COG0497	DNA recombination
D0Y85_RS08470	COG1420	regulation of RNA biosynthetic process
D0Y85_RS08480	COG0443	Heat shock 70 kDa protein
D0Y85_RS08485	COG0484	heat shock protein binding
D0Y85_RS08490	COG2207	Transcriptional regulator
D0Y85_RS08495	COG2223	nitrite transmembrane transporter activity
D0Y85_RS08500	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D0Y85_RS08505	COG0287	Prephenate dehydrogenase
D0Y85_RS08505	COG1605	Chorismate mutase
D0Y85_RS08515	COG1132	(ABC) transporter
D0Y85_RS08535	COG3706	GGDEF domain
D0Y85_RS08535	COG4251	negative regulation of phosphorylation
D0Y85_RS08535	COG2203	Gaf domain
D0Y85_RS08535	COG5001	Diguanylate cyclase
D0Y85_RS08545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0Y85_RS08550	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D0Y85_RS08555	COG0343	queuine tRNA-ribosyltransferase activity
D0Y85_RS08560	COG1862	Preprotein translocase
D0Y85_RS08570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0Y85_RS08575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0Y85_RS08585	COG2081	HI0933 family
D0Y85_RS08595	COG0564	pseudouridine synthase activity
D0Y85_RS08620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D0Y85_RS08630	COG3420	alginic acid biosynthetic process
D0Y85_RS08640	COG0710	3-dehydroquinate dehydratase activity
D0Y85_RS08655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D0Y85_RS08665	COG3485	protocatechuate 3,4-dioxygenase
D0Y85_RS08670	COG3485	protocatechuate 3,4-dioxygenase
D0Y85_RS08680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0Y85_RS08685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Y85_RS08690	COG1414	Transcriptional regulator
D0Y85_RS08700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0Y85_RS08705	COG0513	Belongs to the DEAD box helicase family
D0Y85_RS08725	COG0583	DNA-binding transcription factor activity
D0Y85_RS08730	COG0488	(ABC) transporter
D0Y85_RS08755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0Y85_RS08770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0Y85_RS08775	COG2957	Belongs to the agmatine deiminase family
D0Y85_RS08785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D0Y85_RS08790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0Y85_RS08800	COG0776	regulation of translation
D0Y85_RS08810	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D0Y85_RS08815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0Y85_RS08825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0Y85_RS08830	COG0183	Belongs to the thiolase family
D0Y85_RS08835	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Y85_RS08835	COG1024	Enoyl-CoA hydratase
D0Y85_RS08845	COG0105	UTP biosynthetic process
D0Y85_RS08850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D0Y85_RS08855	COG0859	PFAM glycosyl transferase family 9
D0Y85_RS08855	COG0457	Tetratricopeptide repeat
D0Y85_RS08860	COG1426	Protein conserved in bacteria
D0Y85_RS08860	COG1426	Protein conserved in bacteria
D0Y85_RS08865	COG2976	Protein conserved in bacteria
D0Y85_RS08870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Y85_RS08875	COG1160	GTP binding
D0Y85_RS08885	COG1309	transcriptional regulator
D0Y85_RS08890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0Y85_RS08895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0Y85_RS08895	COG0475	glutathione-regulated potassium exporter activity
D0Y85_RS08925	COG0583	DNA-binding transcription factor activity
D0Y85_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS08990	COG0640	Transcriptional regulator
D0Y85_RS09000	COG4716	Myosin-crossreactive antigen
D0Y85_RS09015	COG0431	NADPH-dependent FMN reductase
D0Y85_RS09025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Y85_RS09030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Y85_RS09035	COG1473	amidohydrolase
D0Y85_RS09045	COG1126	abc transporter atp-binding protein
D0Y85_RS09050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y85_RS09105	COG0697	spore germination
D0Y85_RS09110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0Y85_RS09115	COG0167	dihydroorotate dehydrogenase activity
D0Y85_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS09135	COG1012	belongs to the aldehyde dehydrogenase family
D0Y85_RS09145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0Y85_RS09150	COG0489	protein tyrosine kinase activity
D0Y85_RS09150	COG3206	protein involved in exopolysaccharide biosynthesis
D0Y85_RS09160	COG4641	Protein conserved in bacteria
D0Y85_RS09160	COG0438	transferase activity, transferring glycosyl groups
D0Y85_RS09180	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D0Y85_RS09185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D0Y85_RS09190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0Y85_RS09190	COG0517	IMP dehydrogenase activity
D0Y85_RS09195	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Y85_RS09210	COG1596	polysaccharide export
D0Y85_RS09280	COG0784	Response regulator, receiver
D0Y85_RS09280	COG4191	Histidine kinase
D0Y85_RS09285	COG3850	Histidine kinase
D0Y85_RS09285	COG3437	response regulator, receiver
D0Y85_RS09285	COG4999	Histidine kinase
D0Y85_RS09285	COG2205	protein histidine kinase activity
D0Y85_RS09290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D0Y85_RS09310	COG0640	Transcriptional regulator
D0Y85_RS09345	COG0527	aspartate kinase activity
D0Y85_RS09345	COG0460	homoserine dehydrogenase
D0Y85_RS09350	COG0083	homoserine kinase activity
D0Y85_RS09355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0Y85_RS09360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Y85_RS09365	COG0124	histidyl-tRNA synthetase
D0Y85_RS09380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D0Y85_RS09385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0Y85_RS09390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Y85_RS09395	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0Y85_RS09395	COG0131	Imidazoleglycerol-phosphate dehydratase
D0Y85_RS09400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0Y85_RS09405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0Y85_RS09410	COG0107	imidazoleglycerol-phosphate synthase activity
D0Y85_RS09415	COG0140	phosphoribosyl-ATP diphosphatase activity
D0Y85_RS09415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0Y85_RS09430	COG0837	glucose binding
D0Y85_RS09435	COG1446	asparaginase
D0Y85_RS09440	COG3142	Participates in the control of copper homeostasis
D0Y85_RS09455	COG0789	Transcriptional regulator
D0Y85_RS09470	COG3537	Alpha-1,2-mannosidase
D0Y85_RS09475	COG1609	Transcriptional regulator
D0Y85_RS09485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Y85_RS09500	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D0Y85_RS09505	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D0Y85_RS09510	COG0235	Class ii aldolase
D0Y85_RS09515	COG0531	amino acid
D0Y85_RS09520	COG0531	amino acid
D0Y85_RS09530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0Y85_RS09535	COG0277	FAD linked oxidase domain protein
D0Y85_RS09550	COG5002	protein histidine kinase activity
D0Y85_RS09555	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS09560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y85_RS09565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0Y85_RS09585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0Y85_RS09610	COG1024	Enoyl-CoA hydratase
D0Y85_RS09620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D0Y85_RS09620	COG1918	ferrous iron import across plasma membrane
D0Y85_RS09635	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0Y85_RS09640	COG0789	Transcriptional regulator
D0Y85_RS09650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D0Y85_RS09655	COG0505	Belongs to the CarA family
D0Y85_RS09665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0Y85_RS09670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Y85_RS09690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0Y85_RS09780	COG3279	Response regulator of the LytR AlgR family
D0Y85_RS09785	COG0501	Belongs to the peptidase M48B family
D0Y85_RS09805	COG1012	belongs to the aldehyde dehydrogenase family
D0Y85_RS09830	COG1024	Enoyl-CoA hydratase
D0Y85_RS09835	COG0318	PFAM AMP-dependent synthetase and ligase
D0Y85_RS09840	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D0Y85_RS09845	COG1012	belongs to the aldehyde dehydrogenase family
D0Y85_RS09850	COG1309	transcriptional regulator
D0Y85_RS09855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0Y85_RS09895	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D0Y85_RS09905	COG0840	transmembrane signaling receptor activity
D0Y85_RS09905	COG0840	transmembrane signaling receptor activity
D0Y85_RS09910	COG0840	transmembrane signaling receptor activity
D0Y85_RS09920	COG0835	chemotaxis
D0Y85_RS09925	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D0Y85_RS09930	COG0840	transmembrane signaling receptor activity
D0Y85_RS09940	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS09950	COG0835	chemotaxis
D0Y85_RS09960	COG1360	Flagellar Motor Protein
D0Y85_RS09965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0Y85_RS09970	COG0643	Histidine kinase
D0Y85_RS09970	COG2198	Histidine kinase
D0Y85_RS09970	COG0784	Response regulator, receiver
D0Y85_RS09975	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D0Y85_RS10000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0Y85_RS10005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0Y85_RS10025	COG1987	bacterial-type flagellum assembly
D0Y85_RS10035	COG3190	flagellar
D0Y85_RS10085	COG1677	Flagellar hook-basal body complex protein FliE
D0Y85_RS10115	COG2197	response regulator
D0Y85_RS10135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0Y85_RS10140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0Y85_RS10175	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0Y85_RS10185	COG4787	bacterial-type flagellum-dependent cell motility
D0Y85_RS10195	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0Y85_RS10200	COG1558	bacterial-type flagellum-dependent cell motility
D0Y85_RS10205	COG1815	bacterial-type flagellum-dependent cell motility
D0Y85_RS10210	COG0784	Response regulator, receiver
D0Y85_RS10210	COG0835	chemotaxis
D0Y85_RS10230	COG5002	protein histidine kinase activity
D0Y85_RS10265	COG2915	High frequency lysogenization protein hflD homolog
D0Y85_RS10270	COG0482	sulfurtransferase activity
D0Y85_RS10285	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D0Y85_RS10295	COG0542	response to heat
D0Y85_RS10325	COG0492	ferredoxin-NADP+ reductase activity
D0Y85_RS10330	COG1674	ftsk spoiiie
D0Y85_RS10345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0Y85_RS10360	COG2819	hydrolase of the alpha beta superfamily
D0Y85_RS10370	COG4558	Periplasmic binding protein
D0Y85_RS10375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0Y85_RS10380	COG1120	ATPase activity
D0Y85_RS10390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0Y85_RS10405	COG2205	protein histidine kinase activity
D0Y85_RS10405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0Y85_RS10485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0Y85_RS10500	COG2828	Protein conserved in bacteria
D0Y85_RS10505	COG0583	DNA-binding transcription factor activity
D0Y85_RS10530	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Y85_RS10545	COG3661	Belongs to the glycosyl hydrolase 67 family
D0Y85_RS10555	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Y85_RS10560	COG0477	Major facilitator Superfamily
D0Y85_RS10570	COG1070	Carbohydrate kinase
D0Y85_RS10625	COG2059	Chromate
D0Y85_RS10630	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS10635	COG2205	protein histidine kinase activity
D0Y85_RS10645	COG2194	sulfuric ester hydrolase activity
D0Y85_RS10660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0Y85_RS10665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0Y85_RS10685	COG2207	Transcriptional regulator
D0Y85_RS10690	COG3459	Glycosyltransferase 36 associated
D0Y85_RS10720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0Y85_RS10725	COG0583	DNA-binding transcription factor activity
D0Y85_RS10730	COG0431	NADPH-dependent FMN reductase
D0Y85_RS10755	COG2610	gluconate transmembrane transporter activity
D0Y85_RS10775	COG0642	Histidine kinase
D0Y85_RS10790	COG0318	PFAM AMP-dependent synthetase and ligase
D0Y85_RS10815	COG1902	pentaerythritol trinitrate reductase activity
D0Y85_RS10820	COG4221	oxidoreductase activity
D0Y85_RS10825	COG0604	alcohol dehydrogenase
D0Y85_RS10875	COG3685	Protein conserved in bacteria
D0Y85_RS10910	COG1063	alcohol dehydrogenase
D0Y85_RS10925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D0Y85_RS10930	COG0363	glucosamine-6-phosphate deaminase activity
D0Y85_RS10945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0Y85_RS10955	COG0346	lactoylglutathione lyase activity
D0Y85_RS10965	COG0583	DNA-binding transcription factor activity
D0Y85_RS11025	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D0Y85_RS11035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0Y85_RS11090	COG2080	2 iron, 2 sulfur cluster binding
D0Y85_RS11095	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D0Y85_RS11100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0Y85_RS11110	COG2068	MobA-Related Protein
D0Y85_RS11130	COG2199	diguanylate cyclase activity
D0Y85_RS11135	COG0708	Exodeoxyribonuclease III
D0Y85_RS11140	COG3214	Protein conserved in bacteria
D0Y85_RS11180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0Y85_RS11185	COG1285	pathogenesis
D0Y85_RS11190	COG4191	Histidine kinase
D0Y85_RS11195	COG4566	intracellular signal transduction
D0Y85_RS11230	COG0243	molybdopterin cofactor binding
D0Y85_RS11245	COG0583	DNA-binding transcription factor activity
D0Y85_RS11250	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS11255	COG3537	Alpha-1,2-mannosidase
D0Y85_RS11265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Y85_RS11275	COG0477	Major facilitator Superfamily
D0Y85_RS11290	COG0583	DNA-binding transcription factor activity
D0Y85_RS11300	COG1335	isochorismatase
D0Y85_RS11305	COG1335	isochorismatase
D0Y85_RS11335	COG0811	peptide transport
D0Y85_RS11365	COG4795	General secretion pathway protein
D0Y85_RS11380	COG1459	type II secretion system
D0Y85_RS11460	COG0840	transmembrane signaling receptor activity
D0Y85_RS11465	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0Y85_RS11470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D0Y85_RS11475	COG4149	molybdate abc transporter
D0Y85_RS11485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Y85_RS11500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0Y85_RS11505	COG2181	nitrate reductase activity
D0Y85_RS11510	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D0Y85_RS11515	COG1140	nitrate reductase beta subunit
D0Y85_RS11520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D0Y85_RS11525	COG2223	nitrite transmembrane transporter activity
D0Y85_RS11535	COG0746	molybdenum cofactor guanylyltransferase activity
D0Y85_RS11540	COG0314	molybdopterin synthase activity
D0Y85_RS11550	COG0303	'Molybdopterin
D0Y85_RS11555	COG0315	cyclic pyranopterin monophosphate synthase activity
D0Y85_RS11555	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0Y85_RS11560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0Y85_RS11585	COG2207	Transcriptional regulator
D0Y85_RS11600	COG1566	PFAM secretion protein HlyD family protein
D0Y85_RS11610	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D0Y85_RS11635	COG2885	chlorophyll binding
D0Y85_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS11665	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D0Y85_RS11665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0Y85_RS11675	COG1535	isochorismatase
D0Y85_RS11675	COG3433	isochorismatase activity
D0Y85_RS11680	COG1021	2,3-dihydroxybenzoate-AMP ligase
D0Y85_RS11695	COG2409	Drug exporters of the RND superfamily
D0Y85_RS11700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0Y85_RS11760	COG1914	H( )-stimulated, divalent metal cation uptake system
D0Y85_RS11775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0Y85_RS11780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0Y85_RS11785	COG3321	synthase
D0Y85_RS11785	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS11785	COG0604	alcohol dehydrogenase
D0Y85_RS11790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0Y85_RS11810	COG0583	DNA-binding transcription factor activity
D0Y85_RS11820	COG4772	TonB-dependent receptor
D0Y85_RS11850	COG2885	chlorophyll binding
D0Y85_RS11850	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D0Y85_RS11885	COG4964	Belongs to the GSP D family
D0Y85_RS11940	COG2814	Major facilitator Superfamily
D0Y85_RS11950	COG1228	amidohydrolase
D0Y85_RS11960	COG1335	isochorismatase
D0Y85_RS11975	COG3850	Histidine kinase
D0Y85_RS11980	COG2197	response regulator
D0Y85_RS12025	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D0Y85_RS12035	COG0583	DNA-binding transcription factor activity
D0Y85_RS12050	COG3161	chorismate lyase activity
D0Y85_RS12105	COG4942	peptidase
D0Y85_RS12125	COG2885	chlorophyll binding
D0Y85_RS12175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D0Y85_RS12185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D0Y85_RS12325	COG0277	FAD linked oxidase domain protein
D0Y85_RS12330	COG1304	FMN binding
D0Y85_RS12335	COG2186	Transcriptional regulator
D0Y85_RS12350	COG1285	pathogenesis
D0Y85_RS12380	COG2814	Major facilitator Superfamily
D0Y85_RS12420	COG0587	DNA-directed DNA polymerase activity
D0Y85_RS12435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D0Y85_RS12465	COG0531	amino acid
D0Y85_RS12480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Y85_RS12485	COG2207	Transcriptional regulator
D0Y85_RS12485	COG1917	Cupin 2, conserved barrel domain protein
D0Y85_RS12490	COG0789	Transcriptional regulator
D0Y85_RS12585	COG3447	MASE1 domain protein
D0Y85_RS12585	COG5002	protein histidine kinase activity
D0Y85_RS12585	COG5001	Diguanylate cyclase
D0Y85_RS12590	COG2183	response to ionizing radiation
D0Y85_RS12615	COG3243	poly(R)-hydroxyalkanoic acid synthase
D0Y85_RS12645	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D0Y85_RS12655	COG0668	transmembrane transport
D0Y85_RS12660	COG1902	pentaerythritol trinitrate reductase activity
D0Y85_RS12695	COG2814	Major facilitator Superfamily
D0Y85_RS12720	COG4774	siderophore transport
D0Y85_RS12765	COG0583	DNA-binding transcription factor activity
D0Y85_RS12770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0Y85_RS12780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0Y85_RS12795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D0Y85_RS12800	COG0077	Prephenate dehydratase
D0Y85_RS12800	COG1605	Chorismate mutase
D0Y85_RS12805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0Y85_RS12845	COG1228	amidohydrolase
D0Y85_RS12860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D0Y85_RS12945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0Y85_RS12950	COG4993	Dehydrogenase
D0Y85_RS12960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D0Y85_RS12970	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D0Y85_RS12980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0Y85_RS12985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0Y85_RS13000	COG0359	binds to the 23S rRNA
D0Y85_RS13005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D0Y85_RS13010	COG0360	Binds together with S18 to 16S ribosomal RNA
D0Y85_RS13020	COG0316	Belongs to the HesB IscA family
D0Y85_RS13025	COG0017	Asparaginyl-tRNA synthetase
D0Y85_RS13040	COG2808	Putative FMN-binding domain
D0Y85_RS13045	COG0288	reversible hydration of carbon dioxide
D0Y85_RS13055	COG3844	kynureninase activity
D0Y85_RS13060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Y85_RS13065	COG2925	Exonuclease
D0Y85_RS13090	COG2902	Dehydrogenase
D0Y85_RS13100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y85_RS13105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0Y85_RS13120	COG1960	acyl-CoA dehydrogenase activity
D0Y85_RS13145	COG2900	Belongs to the SlyX family
D0Y85_RS13160	COG0386	Belongs to the glutathione peroxidase family
D0Y85_RS13170	COG1725	Transcriptional regulator
D0Y85_RS13175	COG1131	(ABC) transporter
D0Y85_RS13210	COG2850	peptidyl-arginine hydroxylation
D0Y85_RS13220	COG0567	Dehydrogenase, E1 component
D0Y85_RS13250	COG0305	Participates in initiation and elongation during chromosome replication
D0Y85_RS13270	COG0625	glutathione transferase activity
D0Y85_RS13290	COG0084	hydrolase, TatD family'
D0Y85_RS13295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0Y85_RS13315	COG2839	Protein conserved in bacteria
D0Y85_RS13345	COG1595	DNA-templated transcription, initiation
D0Y85_RS13350	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0Y85_RS13365	COG0386	Belongs to the glutathione peroxidase family
D0Y85_RS13370	COG0339	signal peptide processing
D0Y85_RS13380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0Y85_RS13400	COG3104	oligopeptide transport
D0Y85_RS13410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0Y85_RS13430	COG0316	Belongs to the HesB IscA family
D0Y85_RS13430	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D0Y85_RS13435	COG2154	pterin-4-alpha-carbinolamine dehydratase
D0Y85_RS13445	COG0428	transporter
D0Y85_RS13455	COG1530	ribonuclease E activity
D0Y85_RS13470	COG0395	ABC-type sugar transport system, permease component
D0Y85_RS13500	COG0271	Belongs to the BolA IbaG family
D0Y85_RS13505	COG2350	Protein conserved in bacteria
D0Y85_RS13510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D0Y85_RS13515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D0Y85_RS13520	COG1187	pseudouridine synthase activity
D0Y85_RS13535	COG2814	Major facilitator Superfamily
D0Y85_RS13555	COG0436	Aminotransferase
D0Y85_RS13580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D0Y85_RS13595	COG4235	cytochrome complex assembly
D0Y85_RS13595	COG3088	subunit of a heme lyase
D0Y85_RS13605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0Y85_RS13615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D0Y85_RS13620	COG4988	ABC transporter
D0Y85_RS13630	COG1294	oxidase, subunit
D0Y85_RS13695	COG0726	polysaccharide deacetylase
D0Y85_RS13695	COG1649	PFAM Uncharacterised BCR, COG1649
D0Y85_RS13700	COG1215	transferase activity, transferring glycosyl groups
D0Y85_RS13710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0Y85_RS13725	COG0165	Argininosuccinate lyase
D0Y85_RS13730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0Y85_RS13740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0Y85_RS13745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0Y85_RS13750	COG0137	argininosuccinate synthase activity
D0Y85_RS13755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D0Y85_RS13770	COG2166	iron-sulfur cluster assembly
D0Y85_RS13790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0Y85_RS13810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0Y85_RS13815	COG0402	S-adenosylhomocysteine deaminase activity
D0Y85_RS13825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0Y85_RS13830	COG1509	lysine 2,3-aminomutase activity
D0Y85_RS13835	COG3300	MHYT domain
D0Y85_RS13835	COG5001	Diguanylate cyclase
D0Y85_RS13845	COG0483	inositol monophosphate 1-phosphatase activity
D0Y85_RS13850	COG0501	Belongs to the peptidase M48B family
D0Y85_RS13860	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS13880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D0Y85_RS13890	COG0802	atpase or kinase
D0Y85_RS13895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0Y85_RS13895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D0Y85_RS13905	COG1570	exodeoxyribonuclease VII activity
D0Y85_RS13920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D0Y85_RS13930	COG4771	TonB-dependent receptor
D0Y85_RS13935	COG1309	transcriptional regulator
D0Y85_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS13970	COG2169	Transcriptional regulator
D0Y85_RS13970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0Y85_RS13975	COG2130	NADP-dependent
D0Y85_RS14000	COG1960	acyl-CoA dehydrogenase activity
D0Y85_RS14015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0Y85_RS14050	COG1309	transcriptional regulator
D0Y85_RS14055	COG2076	Multidrug Resistance protein
D0Y85_RS14065	COG1280	lysine exporter protein (LysE YggA)
D0Y85_RS14075	COG1794	racemase activity, acting on amino acids and derivatives
D0Y85_RS14120	COG0776	regulation of translation
D0Y85_RS14130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D0Y85_RS14135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D0Y85_RS14145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D0Y85_RS14150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D0Y85_RS14195	COG1185	polyribonucleotide nucleotidyltransferase activity
D0Y85_RS14200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0Y85_RS14210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D0Y85_RS14215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D0Y85_RS14220	COG0195	Participates in both transcription termination and antitermination
D0Y85_RS14225	COG0779	Required for maturation of 30S ribosomal subunits
D0Y85_RS14240	COG1007	ATP synthesis coupled electron transport
D0Y85_RS14265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Y85_RS14270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D0Y85_RS14280	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D0Y85_RS14285	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D0Y85_RS14290	COG0649	NAD binding
D0Y85_RS14295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Y85_RS14300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Y85_RS14305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0Y85_RS14320	COG0149	triose-phosphate isomerase activity
D0Y85_RS14335	COG0438	transferase activity, transferring glycosyl groups
D0Y85_RS14340	COG0726	polysaccharide deacetylase
D0Y85_RS14345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0Y85_RS14350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0Y85_RS14355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0Y85_RS14360	COG0159	tryptophan synthase activity
D0Y85_RS14370	COG0133	tryptophan synthase activity
D0Y85_RS14405	COG0135	phosphoribosylanthranilate isomerase activity
D0Y85_RS14410	COG0101	tRNA pseudouridine synthase activity
D0Y85_RS14425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0Y85_RS14430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0Y85_RS14435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D0Y85_RS14440	COG2890	protein-(glutamine-N5) methyltransferase activity
D0Y85_RS14445	COG1999	signal sequence binding
D0Y85_RS14450	COG0688	phosphatidylethanolamine metabolic process
D0Y85_RS14465	COG0433	COG0433 Predicted ATPase
D0Y85_RS14470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0Y85_RS14480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0Y85_RS14490	COG0412	Dienelactone hydrolase
D0Y85_RS14500	COG0717	Belongs to the dCTP deaminase family
D0Y85_RS14505	COG0489	protein tyrosine kinase activity
D0Y85_RS14510	COG4771	TonB-dependent receptor
D0Y85_RS14515	COG4771	TonB-dependent receptor
D0Y85_RS14520	COG4771	TonB-dependent receptor
D0Y85_RS14530	COG4771	TonB-dependent receptor
D0Y85_RS14535	COG4771	TonB-dependent receptor
D0Y85_RS14540	COG3590	peptidase
D0Y85_RS14580	COG0697	spore germination
D0Y85_RS14590	COG2311	Membrane
D0Y85_RS14595	COG1047	Peptidyl-prolyl cis-trans
D0Y85_RS14600	COG0791	NLP P60 protein
D0Y85_RS14645	COG1301	dicarboxylic acid transport
D0Y85_RS14665	COG1722	exodeoxyribonuclease VII activity
D0Y85_RS14670	COG0142	geranyltranstransferase activity
D0Y85_RS14680	COG0312	modulator of DNA gyrase
D0Y85_RS14685	COG3028	Belongs to the UPF0307 family
D0Y85_RS14690	COG0312	modulator of DNA gyrase
D0Y85_RS14710	COG2968	Membrane
D0Y85_RS14720	COG4771	TonB-dependent receptor
D0Y85_RS14735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D0Y85_RS14745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0Y85_RS14760	COG0495	leucyl-tRNA aminoacylation
D0Y85_RS14770	COG3118	belongs to the thioredoxin family
D0Y85_RS14780	COG3706	GGDEF domain
D0Y85_RS14780	COG4251	negative regulation of phosphorylation
D0Y85_RS14780	COG5001	Diguanylate cyclase
D0Y85_RS14780	COG2203	Gaf domain
D0Y85_RS14805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0Y85_RS14820	COG0346	lactoylglutathione lyase activity
D0Y85_RS14830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Y85_RS14830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0Y85_RS14840	COG2878	Part of a membrane complex involved in electron transport
D0Y85_RS14850	COG0251	oxidation-reduction process
D0Y85_RS14855	COG0392	lysyltransferase activity
D0Y85_RS14855	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D0Y85_RS14885	COG2824	Alkylphosphonate utilization operon protein PhnA
D0Y85_RS14890	COG0443	Heat shock 70 kDa protein
D0Y85_RS14940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0Y85_RS14945	COG3122	Protein conserved in bacteria
D0Y85_RS14950	COG1451	nucleotide metabolic process
D0Y85_RS14960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0Y85_RS14980	COG0183	Belongs to the thiolase family
D0Y85_RS14995	COG1960	acyl-CoA dehydrogenase activity
D0Y85_RS15005	COG1793	dna ligase
D0Y85_RS15010	COG1201	RNA secondary structure unwinding
D0Y85_RS15025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0Y85_RS15030	COG1278	Cold shock
D0Y85_RS15035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D0Y85_RS15040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D0Y85_RS15045	COG1472	Belongs to the glycosyl hydrolase 3 family
D0Y85_RS15055	COG2954	triphosphatase activity
D0Y85_RS15065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0Y85_RS15070	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS15085	COG1381	Involved in DNA repair and RecF pathway recombination
D0Y85_RS15090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0Y85_RS15105	COG0681	Belongs to the peptidase S26 family
D0Y85_RS15110	COG0481	GTPase activity
D0Y85_RS15115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0Y85_RS15130	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0Y85_RS15130	COG1024	Enoyl-CoA hydratase
D0Y85_RS15135	COG1741	Belongs to the pirin family
D0Y85_RS15140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0Y85_RS15150	COG1741	Belongs to the pirin family
D0Y85_RS15160	COG1966	Carbon starvation protein
D0Y85_RS15165	COG2879	small protein
D0Y85_RS15185	COG2205	protein histidine kinase activity
D0Y85_RS15190	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS15195	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0Y85_RS15225	COG2814	Major facilitator Superfamily
D0Y85_RS15230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0Y85_RS15230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0Y85_RS15240	COG1113	amino acid transport
D0Y85_RS15245	COG2207	Transcriptional regulator
D0Y85_RS15245	COG1917	Cupin 2, conserved barrel domain protein
D0Y85_RS15250	COG0753	catalase activity
D0Y85_RS15265	COG1376	ErfK ybiS ycfS ynhG family protein
D0Y85_RS15270	COG0739	heme binding
D0Y85_RS15280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0Y85_RS15290	COG0330	HflC and HflK could
D0Y85_RS15295	COG0330	HflC and HflK could
D0Y85_RS15300	COG0604	alcohol dehydrogenase
D0Y85_RS15325	COG4953	penicillin-binding protein 1C
D0Y85_RS15330	COG2373	Large extracellular alpha-helical protein
D0Y85_RS15335	COG2079	MmgE PrpD family protein
D0Y85_RS15340	COG2828	Protein conserved in bacteria
D0Y85_RS15370	COG3829	transcription factor binding
D0Y85_RS15395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0Y85_RS15415	COG0477	Major facilitator Superfamily
D0Y85_RS15430	COG2205	protein histidine kinase activity
D0Y85_RS15430	COG2198	Histidine kinase
D0Y85_RS15430	COG0784	Response regulator, receiver
D0Y85_RS15440	COG3038	cytochrome b561
D0Y85_RS15455	COG1760	l-serine dehydratase
D0Y85_RS15460	COG0596	Alpha beta hydrolase
D0Y85_RS15465	COG0460	homoserine dehydrogenase
D0Y85_RS15465	COG0527	aspartate kinase activity
D0Y85_RS15470	COG0626	cystathionine gamma-synthase activity
D0Y85_RS15475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0Y85_RS15480	COG0739	heme binding
D0Y85_RS15485	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D0Y85_RS15490	COG1272	protein, Hemolysin III
D0Y85_RS15495	COG2982	Protein involved in outer membrane biogenesis
D0Y85_RS15505	COG0463	Glycosyl transferase, family 2
D0Y85_RS15515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D0Y85_RS15525	COG4771	TonB-dependent receptor
D0Y85_RS15530	COG1309	transcriptional regulator
D0Y85_RS15540	COG1960	acyl-CoA dehydrogenase activity
D0Y85_RS15570	COG0583	DNA-binding transcription factor activity
D0Y85_RS15580	COG0509	glycine decarboxylation via glycine cleavage system
D0Y85_RS15585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D0Y85_RS15595	COG0330	HflC and HflK could
D0Y85_RS15600	COG2186	Transcriptional regulator
D0Y85_RS15620	COG2271	Major facilitator Superfamily
D0Y85_RS15625	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS15635	COG1742	UPF0060 membrane protein
D0Y85_RS15640	COG3956	TIGRFAM MazG family protein
D0Y85_RS15645	COG1218	3'(2'),5'-bisphosphate nucleotidase
D0Y85_RS15650	COG0494	nUDIX hydrolase
D0Y85_RS15660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0Y85_RS15675	COG0643	Histidine kinase
D0Y85_RS15675	COG0784	Response regulator, receiver
D0Y85_RS15675	COG2198	Histidine kinase
D0Y85_RS15680	COG0840	transmembrane signaling receptor activity
D0Y85_RS15685	COG0835	chemotaxis
D0Y85_RS15700	COG0189	ligase activity
D0Y85_RS15715	COG1199	ATP-dependent helicase activity
D0Y85_RS15725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0Y85_RS15730	COG1442	glycosyl transferase family 8
D0Y85_RS15730	COG1216	Glycosyl transferase, family 2
D0Y85_RS15740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Y85_RS15750	COG1643	Atp-dependent helicase
D0Y85_RS15755	COG0783	Belongs to the Dps family
D0Y85_RS15760	COG0514	ATP-dependent DNA helicase (RecQ)
D0Y85_RS15770	COG2132	Multicopper oxidase
D0Y85_RS15860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D0Y85_RS15865	COG0602	queuosine metabolic process
D0Y85_RS15875	COG2885	chlorophyll binding
D0Y85_RS15880	COG0823	Involved in the tonB-independent uptake of proteins
D0Y85_RS15900	COG0824	Thioesterase
D0Y85_RS15905	COG2255	four-way junction helicase activity
D0Y85_RS15915	COG0632	four-way junction helicase activity
D0Y85_RS15920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D0Y85_RS15925	COG0217	transcriptional regulatory protein
D0Y85_RS15945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D0Y85_RS15960	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D0Y85_RS15975	COG0488	(ABC) transporter
D0Y85_RS16000	COG4651	solute:proton antiporter activity
D0Y85_RS16000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0Y85_RS16015	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS16020	COG2205	protein histidine kinase activity
D0Y85_RS16050	COG0028	Belongs to the TPP enzyme family
D0Y85_RS16075	COG3387	PFAM Glycoside hydrolase 15-related
D0Y85_RS16080	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D0Y85_RS16095	COG0564	pseudouridine synthase activity
D0Y85_RS16100	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0Y85_RS16110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0Y85_RS16110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0Y85_RS16135	COG1132	(ABC) transporter
D0Y85_RS16140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D0Y85_RS16145	COG0045	succinate-CoA ligase (ADP-forming) activity
D0Y85_RS16165	COG4969	Belongs to the N-Me-Phe pilin family
D0Y85_RS16170	COG4969	Belongs to the N-Me-Phe pilin family
D0Y85_RS16180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D0Y85_RS16200	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS16215	COG0189	ligase activity
D0Y85_RS16230	COG4625	pathogenesis
D0Y85_RS16230	COG3240	lipase activity
D0Y85_RS16240	COG2022	thiamine diphosphate biosynthetic process
D0Y85_RS16245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D0Y85_RS16250	COG3273	potassium ion transport
D0Y85_RS16250	COG0471	metal ion transport
D0Y85_RS16270	COG1970	mechanosensitive ion channel activity
D0Y85_RS16280	COG1115	amino acid carrier protein
D0Y85_RS16290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0Y85_RS16295	COG1115	amino acid carrier protein
D0Y85_RS16305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0Y85_RS16325	COG0583	DNA-binding transcription factor activity
D0Y85_RS16335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D0Y85_RS16345	COG3588	fructose-bisphosphate aldolase
D0Y85_RS16350	COG0469	pyruvate kinase activity
D0Y85_RS16360	COG0126	phosphoglycerate kinase activity
D0Y85_RS16380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0Y85_RS16385	COG3047	cAMP biosynthetic process
D0Y85_RS16430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0Y85_RS16435	COG1301	dicarboxylic acid transport
D0Y85_RS16445	COG2304	oxidoreductase activity
D0Y85_RS16465	COG0714	Associated with various cellular activities
D0Y85_RS16495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D0Y85_RS16545	COG0254	rRNA binding
D0Y85_RS16555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0Y85_RS16565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0Y85_RS16570	COG1758	RNA polymerase activity
D0Y85_RS16580	COG1561	YicC-like family, N-terminal region
D0Y85_RS16585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D0Y85_RS16590	COG0346	lactoylglutathione lyase activity
D0Y85_RS16600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0Y85_RS16615	COG0006	proline dipeptidase activity
D0Y85_RS16620	COG0006	proline dipeptidase activity
D0Y85_RS16625	COG3079	Belongs to the UPF0149 family
D0Y85_RS16645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0Y85_RS16655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D0Y85_RS16665	COG2912	Transglutaminase-like superfamily
D0Y85_RS16670	COG1773	rubredoxin
D0Y85_RS16680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0Y85_RS16685	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D0Y85_RS16695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0Y85_RS16700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Y85_RS16715	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS16735	COG0671	phosphoesterase, PA-phosphatase related
D0Y85_RS16745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0Y85_RS16750	COG0563	adenylate kinase activity
D0Y85_RS16775	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D0Y85_RS16795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0Y85_RS16805	COG4771	TonB-dependent receptor
D0Y85_RS16815	COG0745	RESPONSE REGULATOR receiver
D0Y85_RS16825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D0Y85_RS16830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0Y85_RS16835	COG0405	Gamma-glutamyltransferase
D0Y85_RS16840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D0Y85_RS16860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0Y85_RS16865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0Y85_RS16880	COG0473	3-isopropylmalate dehydrogenase activity
D0Y85_RS16915	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D0Y85_RS16920	COG1538	Outer membrane efflux protein
D0Y85_RS16930	COG1519	Transferase
D0Y85_RS16935	COG1560	Kdo2-lipid A biosynthetic process
D0Y85_RS16975	COG1301	dicarboxylic acid transport
D0Y85_RS16985	COG4191	Histidine kinase
D0Y85_RS17000	COG0642	Histidine kinase
D0Y85_RS17015	COG2851	Citrate transporter
D0Y85_RS17020	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS17040	COG1162	GTPase activity
D0Y85_RS17060	COG0726	polysaccharide deacetylase
D0Y85_RS17065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0Y85_RS17080	COG1228	amidohydrolase
D0Y85_RS17085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0Y85_RS17095	COG1307	EDD domain protein, DegV family
D0Y85_RS17140	COG3706	GGDEF domain
D0Y85_RS17140	COG2203	Gaf domain
D0Y85_RS17140	COG5001	Diguanylate cyclase
D0Y85_RS17140	COG4251	negative regulation of phosphorylation
D0Y85_RS17145	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D0Y85_RS17150	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D0Y85_RS17160	COG0583	DNA-binding transcription factor activity
D0Y85_RS17165	COG1902	pentaerythritol trinitrate reductase activity
D0Y85_RS17180	COG0583	DNA-binding transcription factor activity
D0Y85_RS17185	COG1064	alcohol dehydrogenase
D0Y85_RS17210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Y85_RS17215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D0Y85_RS17230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0Y85_RS17245	COG1522	sequence-specific DNA binding
D0Y85_RS17255	COG4773	Receptor
D0Y85_RS17275	COG0617	tRNA 3'-terminal CCA addition
D0Y85_RS17330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0Y85_RS17335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Y85_RS17340	COG1609	Transcriptional regulator
D0Y85_RS17360	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D0Y85_RS17380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0Y85_RS17395	COG0784	Response regulator, receiver
D0Y85_RS17400	COG4251	negative regulation of phosphorylation
D0Y85_RS17405	COG2823	Periplasmic or secreted lipoprotein
D0Y85_RS17410	COG0673	inositol 2-dehydrogenase activity
D0Y85_RS17415	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D0Y85_RS17435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D0Y85_RS17445	COG2921	Belongs to the UPF0250 family
D0Y85_RS17460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0Y85_RS17465	COG2951	lytic endotransglycosylase activity
D0Y85_RS17485	COG0772	Belongs to the SEDS family
D0Y85_RS17490	COG0768	penicillin binding
D0Y85_RS17500	COG1792	Involved in formation and maintenance of cell shape
D0Y85_RS17505	COG1077	Cell shape determining protein MreB Mrl
D0Y85_RS17510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0Y85_RS17515	COG1368	sulfuric ester hydrolase activity
D0Y85_RS17520	COG0546	phosphoglycolate phosphatase activity
D0Y85_RS17530	COG0308	aminopeptidase N
D0Y85_RS17535	COG2226	methyltransferase
D0Y85_RS17560	COG1943	Transposase
D0Y85_RS17570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0Y85_RS17575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y85_RS17590	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D0Y85_RS17610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0Y85_RS17620	COG2832	Protein of unknown function (DUF454)
D0Y85_RS17630	COG0436	Aminotransferase
D0Y85_RS17635	COG1505	serine-type exopeptidase activity
D0Y85_RS17650	COG2011	ABC-type metal ion transport system permease component
D0Y85_RS17655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0Y85_RS17660	COG0697	spore germination
D0Y85_RS17665	COG1666	GTP binding
D0Y85_RS17695	COG0339	signal peptide processing
D0Y85_RS17705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0Y85_RS17720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0Y85_RS17720	COG0517	IMP dehydrogenase activity
D0Y85_RS17725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0Y85_RS17735	COG1136	(ABC) transporter
D0Y85_RS17745	COG0577	efflux transmembrane transporter activity
D0Y85_RS17745	COG1136	(ABC) transporter
D0Y85_RS17755	COG2204	response regulator
D0Y85_RS17760	COG4191	Histidine kinase
D0Y85_RS17770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0Y85_RS17780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0Y85_RS17785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D0Y85_RS17790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0Y85_RS17795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D0Y85_RS17800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0Y85_RS17805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D0Y85_RS17815	COG0356	it plays a direct role in the translocation of protons across the membrane
D0Y85_RS17830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0Y85_RS17835	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0Y85_RS17855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0Y85_RS17880	COG0181	hydroxymethylbilane synthase activity
D0Y85_RS17890	COG3275	phosphorelay sensor kinase activity
D0Y85_RS17895	COG0400	carboxylic ester hydrolase activity
D0Y85_RS17905	COG4771	TonB-dependent receptor
D0Y85_RS17915	COG0840	transmembrane signaling receptor activity
D0Y85_RS17950	COG1764	response to oxidative stress
D0Y85_RS17960	COG0583	DNA-binding transcription factor activity
D0Y85_RS17980	COG1595	DNA-templated transcription, initiation
D0Y85_RS17990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0Y85_RS18035	COG0625	glutathione transferase activity
D0Y85_RS18045	COG1733	regulation of RNA biosynthetic process
D0Y85_RS18135	COG0641	radical SAM
D0Y85_RS18145	COG0667	Aldo Keto reductase
D0Y85_RS18180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0Y85_RS18185	COG1490	D-aminoacyl-tRNA deacylase activity
D0Y85_RS18225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0Y85_RS18230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0Y85_RS18230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0Y85_RS18235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0Y85_RS18240	COG0242	peptide deformylase activity
D0Y85_RS18245	COG1652	LysM domain
D0Y85_RS18250	COG0758	DNA mediated transformation
D0Y85_RS18255	COG2922	Belongs to the Smg family
D0Y85_RS18265	COG1714	RDD family
D0Y85_RS18270	COG1754	DNA topoisomerase type I activity
D0Y85_RS18270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0Y85_RS18275	COG0009	L-threonylcarbamoyladenylate synthase
D0Y85_RS18300	COG0616	signal peptide processing
D0Y85_RS18305	COG0534	Mate efflux family protein
D0Y85_RS18320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0Y85_RS18325	COG0625	glutathione transferase activity
D0Y85_RS18340	COG1252	NADH dehydrogenase
D0Y85_RS18355	COG2860	membrane
D0Y85_RS18365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0Y85_RS18385	COG1846	Transcriptional regulator
D0Y85_RS18395	COG0459	protein refolding
D0Y85_RS18400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D0Y85_RS18405	COG2356	endonuclease I
D0Y85_RS18410	COG1324	tolerance protein
D0Y85_RS18420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0Y85_RS18430	COG0840	transmembrane signaling receptor activity
D0Y85_RS18450	COG0583	DNA-binding transcription factor activity
D0Y85_RS18465	COG1686	Belongs to the peptidase S11 family
D0Y85_RS18480	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0Y85_RS18495	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0Y85_RS18505	COG0511	ligase activity, forming carbon-carbon bonds
D0Y85_RS18510	COG0439	Biotin carboxylase
D0Y85_RS18525	COG2264	protein methyltransferase activity
D0Y85_RS18535	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D0Y85_RS18540	COG4589	Belongs to the CDS family
D0Y85_RS18555	COG0671	phosphoesterase, PA-phosphatase related
D0Y85_RS18555	COG2453	phosphatase
D0Y85_RS18560	COG2267	carboxylic ester hydrolase activity
D0Y85_RS18565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0Y85_RS18570	COG0138	bifunctional purine biosynthesis protein purh
D0Y85_RS18580	COG0151	Belongs to the GarS family
D0Y85_RS18585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0Y85_RS18590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0Y85_RS18595	COG2201	protein-glutamate methylesterase activity
D0Y85_RS18600	COG2177	Part of the ABC transporter FtsEX involved in
D0Y85_RS18605	COG2884	Cell division ATP-binding protein ftsE
D0Y85_RS18615	COG3118	belongs to the thioredoxin family
D0Y85_RS18625	COG3706	GGDEF domain
D0Y85_RS18640	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D0Y85_RS18675	COG1652	LysM domain
D0Y85_RS18680	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0Y85_RS18680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0Y85_RS18685	COG1473	amidohydrolase
D0Y85_RS18690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0Y85_RS18710	COG1289	transmembrane transporter activity
D0Y85_RS18745	COG0316	Belongs to the HesB IscA family
D0Y85_RS18790	COG1051	belongs to the nudix hydrolase family
D0Y85_RS18805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D0Y85_RS18810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D0Y85_RS18815	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D0Y85_RS18825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D0Y85_RS18830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0Y85_RS18835	COG0730	response to heat
D0Y85_RS18845	COG0134	indole-3-glycerol-phosphate synthase activity
D0Y85_RS18850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0Y85_RS18865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0Y85_RS18865	COG2755	lipolytic protein G-D-S-L family
D0Y85_RS18870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0Y85_RS18875	COG1597	lipid kinase activity
D0Y85_RS18895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0Y85_RS18900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D0Y85_RS18910	COG2111	Na H antiporter
D0Y85_RS18910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0Y85_RS18915	COG1006	Multisubunit Na H antiporter MnhC subunit
D0Y85_RS18920	COG0651	ATP synthesis coupled electron transport
D0Y85_RS18925	COG1863	multisubunit Na H antiporter MnhE subunit
D0Y85_RS18930	COG2212	antiporter activity
D0Y85_RS18935	COG1320	monovalent cation:proton antiporter activity
D0Y85_RS18955	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D0Y85_RS18975	COG4804	nuclease activity
D0Y85_RS18990	COG3104	oligopeptide transport
D0Y85_RS18995	COG3483	tryptophan 2,3-dioxygenase activity
D0Y85_RS19000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D0Y85_RS19025	COG2378	regulation of single-species biofilm formation
D0Y85_RS19040	COG2354	Protein conserved in bacteria
D0Y85_RS19060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D0Y85_RS19060	COG3264	Mechanosensitive ion channel
D0Y85_RS19070	COG3040	lipid binding
D0Y85_RS19075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0Y85_RS19075	COG0723	plastoquinol--plastocyanin reductase activity
D0Y85_RS19110	COG1166	arginine decarboxylase activity
D0Y85_RS19115	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D0Y85_RS19130	COG0347	Belongs to the P(II) protein family
D0Y85_RS19135	COG2960	long-chain fatty acid transporting porin activity
D0Y85_RS19165	COG0606	chelatase, subunit chli
D0Y85_RS19190	COG0561	phosphatase activity
D0Y85_RS19195	COG3932	Exopolysaccharide synthesis, ExoD
D0Y85_RS19225	COG1999	signal sequence binding
D0Y85_RS19230	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0Y85_RS19235	COG1845	cytochrome c oxidase, subunit III
D0Y85_RS19245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0Y85_RS19250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Y85_RS19265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0Y85_RS19270	COG1104	cysteine desulfurase activity
D0Y85_RS19295	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D0Y85_RS19320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0Y85_RS19325	COG2031	fatty acid transporter
D0Y85_RS19355	COG0673	inositol 2-dehydrogenase activity
D0Y85_RS19365	COG1501	Belongs to the glycosyl hydrolase 31 family
D0Y85_RS19370	COG2222	sugar isomerase
D0Y85_RS19375	COG1940	carbohydrate kinase activity
D0Y85_RS19385	COG1349	DNA-binding transcription factor activity
D0Y85_RS19395	COG2814	Major facilitator Superfamily
D0Y85_RS19410	COG1040	competence protein
D0Y85_RS19420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D0Y85_RS19425	COG0156	8-amino-7-oxononanoate synthase activity
D0Y85_RS19430	COG2267	carboxylic ester hydrolase activity
D0Y85_RS19435	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS19450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0Y85_RS19465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0Y85_RS19490	COG0714	Associated with various cellular activities
D0Y85_RS19505	COG0754	glutathionylspermidine amidase activity
D0Y85_RS19515	COG0129	dihydroxy-acid dehydratase activity
D0Y85_RS19525	COG1199	ATP-dependent helicase activity
D0Y85_RS19535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0Y85_RS19555	COG3781	membrane
D0Y85_RS19585	COG0625	glutathione transferase activity
D0Y85_RS19605	COG2207	Transcriptional regulator
D0Y85_RS19615	COG4555	ABC transporter
D0Y85_RS19645	COG1131	(ABC) transporter
D0Y85_RS19650	COG0842	Transport permease protein
D0Y85_RS19655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0Y85_RS19665	COG0084	hydrolase, TatD family'
D0Y85_RS19670	COG1643	Atp-dependent helicase
D0Y85_RS19680	COG1187	pseudouridine synthase activity
D0Y85_RS19690	COG0667	Aldo Keto reductase
D0Y85_RS19710	COG0583	DNA-binding transcription factor activity
D0Y85_RS19715	COG2814	Major facilitator Superfamily
D0Y85_RS19725	COG2267	carboxylic ester hydrolase activity
D0Y85_RS19730	COG0393	Putative heavy-metal-binding
D0Y85_RS19735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0Y85_RS19735	COG1042	CoA-binding domain protein
D0Y85_RS19735	COG0045	succinate-CoA ligase (ADP-forming) activity
D0Y85_RS19740	COG2239	Acts as a magnesium transporter
D0Y85_RS19755	COG0666	response to abiotic stimulus
D0Y85_RS19755	COG3177	Filamentation induced by cAMP protein fic
D0Y85_RS19760	COG3100	YcgL domain-containing protein
D0Y85_RS19775	COG1028	Short-chain dehydrogenase reductase Sdr
D0Y85_RS19795	COG0644	oxidoreductase
D0Y85_RS19815	COG2986	histidine ammonia-lyase
D0Y85_RS19825	COG0463	Glycosyl transferase, family 2
D0Y85_RS19840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Y85_RS19845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0Y85_RS19860	COG1294	oxidase, subunit
D0Y85_RS19865	COG1271	oxidase subunit
D0Y85_RS19885	COG1595	DNA-templated transcription, initiation
D0Y85_RS19920	COG0408	coproporphyrinogen oxidase activity
D0Y85_RS19930	COG2323	membrane
D0Y85_RS19950	COG0589	response to stress
D0Y85_RS19965	COG0210	DNA helicase
D0Y85_RS19975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0Y85_RS19980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0Y85_RS19985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D0Y85_RS19995	COG1819	glycosyl
D0Y85_RS20005	COG0251	oxidation-reduction process
D0Y85_RS20040	COG0463	Glycosyl transferase, family 2
D0Y85_RS20055	COG1475	DNA binding
D0Y85_RS20060	COG1192	Involved in chromosome partitioning
D0Y85_RS20065	COG0357	Ribosomal RNA small subunit methyltransferase G
D0Y85_RS20070	COG2091	lysine biosynthetic process via aminoadipic acid
D0Y85_RS20115	COG1971	Probably functions as a manganese efflux pump
D0Y85_RS20120	COG2205	protein histidine kinase activity
D0Y85_RS20120	COG0784	Response regulator, receiver
D0Y85_RS20130	COG2911	Protein conserved in bacteria
D0Y85_RS20135	COG0729	surface antigen
D0Y85_RS20145	COG0752	glycyl-tRNA synthetase alpha subunit
D0Y85_RS20150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0Y85_RS20155	COG0519	Catalyzes the synthesis of GMP from XMP
D0Y85_RS20155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0Y85_RS20165	COG0805	protein transport
D0Y85_RS20175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0Y85_RS20185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0Y85_RS20195	COG0840	transmembrane signaling receptor activity
D0Y85_RS20225	COG3135	benzoate transporter
D0Y85_RS20235	COG0676	glucose-6-phosphate 1-epimerase activity
D0Y85_RS20240	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D0Y85_RS20245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D0Y85_RS20280	COG0302	gtp cyclohydrolase
D0Y85_RS20295	COG1566	PFAM secretion protein HlyD family protein
D0Y85_RS20300	COG1538	Outer membrane efflux protein
D0Y85_RS20305	COG1289	transmembrane transporter activity
D0Y85_RS20320	COG1074	ATP-dependent DNA helicase activity
D0Y85_RS20325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D0Y85_RS20330	COG1127	ABC transporter
D0Y85_RS20335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0Y85_RS20340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0Y85_RS20355	COG2853	Lipoprotein
D0Y85_RS20360	COG0386	Belongs to the glutathione peroxidase family
D0Y85_RS20370	COG1322	Protein conserved in bacteria
D0Y85_RS20390	COG0583	DNA-binding transcription factor activity
D0Y85_RS20405	COG0667	Aldo Keto reductase
D0Y85_RS20415	COG0531	amino acid
D0Y85_RS20425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D0Y85_RS20430	COG0861	Integral membrane protein TerC family
D0Y85_RS20440	COG0584	glycerophosphoryl diester phosphodiesterase
D0Y85_RS20465	COG0706	membrane insertase activity
D0Y85_RS20470	COG0594	ribonuclease P activity
D0Y85_RS20475	COG0230	Belongs to the bacterial ribosomal protein bL34 family