locus-tag	class	description
AXG53_RS00025	COG2132	Multicopper oxidase
AXG53_RS00090	COG0789	Transcriptional regulator
AXG53_RS00105	COG2217	Heavy metal translocating P-type atpase
AXG53_RS00115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AXG53_RS00120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AXG53_RS00140	COG2217	Heavy metal translocating P-type atpase
AXG53_RS00145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AXG53_RS00215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXG53_RS00220	COG0443	Heat shock 70 kDa protein
AXG53_RS00225	COG0542	response to heat
AXG53_RS00235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AXG53_RS00240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXG53_RS00240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXG53_RS00250	COG4993	Dehydrogenase
AXG53_RS00270	COG3039	Transposase
AXG53_RS00310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AXG53_RS00320	COG2200	EAL domain
AXG53_RS00320	COG2199	diguanylate cyclase activity
AXG53_RS00325	COG2837	iron assimilation
AXG53_RS00355	COG2207	Transcriptional regulator
AXG53_RS00365	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS00395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXG53_RS00420	COG5002	protein histidine kinase activity
AXG53_RS00420	COG5001	Diguanylate cyclase
AXG53_RS00450	COG0251	oxidation-reduction process
AXG53_RS00465	COG2211	Major facilitator Superfamily
AXG53_RS00470	COG1472	Belongs to the glycosyl hydrolase 3 family
AXG53_RS00485	COG3661	Belongs to the glycosyl hydrolase 67 family
AXG53_RS00495	COG1472	Belongs to the glycosyl hydrolase 3 family
AXG53_RS00500	COG0477	Major facilitator Superfamily
AXG53_RS00510	COG1070	Carbohydrate kinase
AXG53_RS00560	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AXG53_RS00570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AXG53_RS00680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXG53_RS00700	COG2197	response regulator
AXG53_RS00705	COG2197	response regulator
AXG53_RS00715	COG3851	Histidine kinase
AXG53_RS00720	COG1752	Esterase of the alpha-beta hydrolase superfamily
AXG53_RS00725	COG3119	arylsulfatase activity
AXG53_RS00735	COG1064	alcohol dehydrogenase
AXG53_RS00750	COG2207	Transcriptional regulator
AXG53_RS00760	COG2197	response regulator
AXG53_RS00770	COG2197	response regulator
AXG53_RS00775	COG3188	usher protein
AXG53_RS00780	COG3121	Chaperone
AXG53_RS00790	COG2203	Gaf domain
AXG53_RS00790	COG3706	GGDEF domain
AXG53_RS00790	COG4251	negative regulation of phosphorylation
AXG53_RS00790	COG5001	Diguanylate cyclase
AXG53_RS00795	COG2205	protein histidine kinase activity
AXG53_RS00795	COG0784	Response regulator, receiver
AXG53_RS00840	COG2201	protein-glutamate methylesterase activity
AXG53_RS00845	COG2183	response to ionizing radiation
AXG53_RS00865	COG3243	poly(R)-hydroxyalkanoic acid synthase
AXG53_RS00875	COG1183	phosphatidylcholine synthase activity
AXG53_RS00890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AXG53_RS00900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AXG53_RS00925	COG0084	hydrolase, TatD family'
AXG53_RS00930	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AXG53_RS00965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXG53_RS00965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXG53_RS00990	COG1595	DNA-templated transcription, initiation
AXG53_RS00995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AXG53_RS01000	COG2860	membrane
AXG53_RS01020	COG0386	Belongs to the glutathione peroxidase family
AXG53_RS01025	COG0339	signal peptide processing
AXG53_RS01030	COG1566	PFAM secretion protein HlyD family protein
AXG53_RS01045	COG1846	Transcriptional regulator
AXG53_RS01050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AXG53_RS01070	COG3104	oligopeptide transport
AXG53_RS01080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AXG53_RS01100	COG0488	(ABC) transporter
AXG53_RS01105	COG0583	DNA-binding transcription factor activity
AXG53_RS01115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXG53_RS01120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXG53_RS01140	COG3279	Response regulator of the LytR AlgR family
AXG53_RS01155	COG1017	nitric oxide dioxygenase activity
AXG53_RS01155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXG53_RS01190	COG0318	PFAM AMP-dependent synthetase and ligase
AXG53_RS01200	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AXG53_RS01210	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AXG53_RS01220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXG53_RS01225	COG3115	cell septum assembly
AXG53_RS01235	COG0359	binds to the 23S rRNA
AXG53_RS01240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXG53_RS01245	COG0360	Binds together with S18 to 16S ribosomal RNA
AXG53_RS01250	COG2814	Major facilitator Superfamily
AXG53_RS01255	COG0316	Belongs to the HesB IscA family
AXG53_RS01280	COG0288	reversible hydration of carbon dioxide
AXG53_RS01295	COG3844	kynureninase activity
AXG53_RS01300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXG53_RS01305	COG2925	Exonuclease
AXG53_RS01340	COG2902	Dehydrogenase
AXG53_RS01355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXG53_RS01360	COG1960	acyl-CoA dehydrogenase activity
AXG53_RS01370	COG0646	methionine synthase
AXG53_RS01370	COG1410	methionine synthase
AXG53_RS01390	COG0583	DNA-binding transcription factor activity
AXG53_RS01395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AXG53_RS01400	COG2814	Major facilitator Superfamily
AXG53_RS01405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AXG53_RS01405	COG2755	lipolytic protein G-D-S-L family
AXG53_RS01415	COG2900	Belongs to the SlyX family
AXG53_RS01430	COG0386	Belongs to the glutathione peroxidase family
AXG53_RS01435	COG1725	Transcriptional regulator
AXG53_RS01440	COG1131	(ABC) transporter
AXG53_RS01475	COG2850	peptidyl-arginine hydroxylation
AXG53_RS01485	COG0567	Dehydrogenase, E1 component
AXG53_RS01495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXG53_RS01525	COG1132	(ABC) transporter
AXG53_RS01535	COG0287	Prephenate dehydrogenase
AXG53_RS01535	COG1605	Chorismate mutase
AXG53_RS01540	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AXG53_RS01545	COG0484	heat shock protein binding
AXG53_RS01550	COG0443	Heat shock 70 kDa protein
AXG53_RS01555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXG53_RS01560	COG0497	DNA recombination
AXG53_RS01570	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AXG53_RS01575	COG2914	Belongs to the UPF0125 (RnfH) family
AXG53_RS01585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AXG53_RS01615	COG2963	transposase activity
AXG53_RS01635	COG0582	viral genome integration into host DNA
AXG53_RS01670	COG0513	Belongs to the DEAD box helicase family
AXG53_RS01680	COG2201	protein-glutamate methylesterase activity
AXG53_RS01700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXG53_RS01705	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AXG53_RS01710	COG0625	glutathione transferase activity
AXG53_RS01715	COG1278	Cold shock
AXG53_RS01725	COG0564	pseudouridine synthase activity
AXG53_RS01730	COG4681	YaeQ
AXG53_RS01735	COG2081	HI0933 family
AXG53_RS01745	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AXG53_RS01750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXG53_RS01760	COG1862	Preprotein translocase
AXG53_RS01765	COG0343	queuine tRNA-ribosyltransferase activity
AXG53_RS01770	COG3842	ATPase activity
AXG53_RS01775	COG1178	ABC-type Fe3 transport system permease component
AXG53_RS01780	COG1840	ABC-type Fe3 transport system, periplasmic component
AXG53_RS01785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AXG53_RS01790	COG1522	sequence-specific DNA binding
AXG53_RS01795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXG53_RS01820	COG0583	DNA-binding transcription factor activity
AXG53_RS01830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AXG53_RS01855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AXG53_RS01860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXG53_RS01865	COG0405	Gamma-glutamyltransferase
AXG53_RS01870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AXG53_RS01880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AXG53_RS01885	COG0742	ribosomal rna small subunit methyltransferase
AXG53_RS01890	COG0326	Molecular chaperone. Has ATPase activity
AXG53_RS01895	COG0552	protein localization to endoplasmic reticulum
AXG53_RS01900	COG1194	a g-specific adenine glycosylase
AXG53_RS01905	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AXG53_RS01920	COG4591	ABC-type transport system involved in lipoprotein release permease component
AXG53_RS01945	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AXG53_RS01965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AXG53_RS01970	COG0837	glucose binding
AXG53_RS01975	COG0363	glucosamine-6-phosphate deaminase activity
AXG53_RS01980	COG0129	dihydroxy-acid dehydratase activity
AXG53_RS01985	COG0800	Aldolase
AXG53_RS01995	COG0395	ABC-type sugar transport system, permease component
AXG53_RS02020	COG1609	Transcriptional regulator
AXG53_RS02025	COG0271	Belongs to the BolA IbaG family
AXG53_RS02030	COG2350	Protein conserved in bacteria
AXG53_RS02040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AXG53_RS02045	COG1187	pseudouridine synthase activity
AXG53_RS02080	COG0436	Aminotransferase
AXG53_RS02135	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AXG53_RS02140	COG1138	Cytochrome C-type biogenesis protein
AXG53_RS02160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXG53_RS02170	COG1278	Cold shock
AXG53_RS02185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AXG53_RS02190	COG4988	ABC transporter
AXG53_RS02200	COG1294	oxidase, subunit
AXG53_RS02240	COG0165	Argininosuccinate lyase
AXG53_RS02255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXG53_RS02260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AXG53_RS02265	COG0137	argininosuccinate synthase activity
AXG53_RS02270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AXG53_RS02285	COG2166	iron-sulfur cluster assembly
AXG53_RS02295	COG1472	Belongs to the glycosyl hydrolase 3 family
AXG53_RS02305	COG1309	transcriptional regulator
AXG53_RS02310	COG0590	tRNA wobble adenosine to inosine editing
AXG53_RS02320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXG53_RS02340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AXG53_RS02345	COG0402	S-adenosylhomocysteine deaminase activity
AXG53_RS02350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXG53_RS02355	COG1509	lysine 2,3-aminomutase activity
AXG53_RS02360	COG5001	Diguanylate cyclase
AXG53_RS02360	COG3300	MHYT domain
AXG53_RS02375	COG0483	inositol monophosphate 1-phosphatase activity
AXG53_RS02385	COG0501	Belongs to the peptidase M48B family
AXG53_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS02415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AXG53_RS02425	COG0802	atpase or kinase
AXG53_RS02430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AXG53_RS02430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AXG53_RS02435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AXG53_RS02440	COG1570	exodeoxyribonuclease VII activity
AXG53_RS02490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AXG53_RS02500	COG1940	carbohydrate kinase activity
AXG53_RS02500	COG1846	Transcriptional regulator
AXG53_RS02505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXG53_RS02515	COG4771	TonB-dependent receptor
AXG53_RS02520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AXG53_RS02525	COG1473	amidohydrolase
AXG53_RS02530	COG1228	amidohydrolase
AXG53_RS02555	COG1960	acyl-CoA dehydrogenase activity
AXG53_RS02565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AXG53_RS02585	COG3040	lipid binding
AXG53_RS02625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXG53_RS02630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AXG53_RS02640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXG53_RS02645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXG53_RS02675	COG0556	nucleotide-excision repair
AXG53_RS02720	COG3275	phosphorelay sensor kinase activity
AXG53_RS02725	COG1611	Belongs to the LOG family
AXG53_RS02735	COG2095	MarC family integral membrane protein
AXG53_RS02740	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS02745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AXG53_RS02755	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AXG53_RS02790	COG2969	positive regulation of protein catabolic process
AXG53_RS02795	COG0625	glutathione transferase activity
AXG53_RS02800	COG2857	Cytochrome c1
AXG53_RS02805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AXG53_RS02810	COG0723	plastoquinol--plastocyanin reductase activity
AXG53_RS02815	COG0741	lytic transglycosylase activity
AXG53_RS02825	COG1702	phosphate starvation-inducible protein PhoH
AXG53_RS02830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXG53_RS02840	COG4535	Mg2 and Co2 transporter CorC
AXG53_RS02855	COG0006	proline dipeptidase activity
AXG53_RS02860	COG1012	belongs to the aldehyde dehydrogenase family
AXG53_RS02865	COG1177	transmembrane transport
AXG53_RS02870	COG1176	ABC-type spermidine putrescine transport system, permease component I
AXG53_RS02875	COG3842	ATPase activity
AXG53_RS02890	COG0519	Catalyzes the synthesis of GMP from XMP
AXG53_RS02890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXG53_RS02895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXG53_RS02905	COG2703	oxygen carrier activity
AXG53_RS02910	COG0477	Major facilitator Superfamily
AXG53_RS02925	COG1012	belongs to the aldehyde dehydrogenase family
AXG53_RS02945	COG2733	membrane
AXG53_RS02970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AXG53_RS02970	COG0116	Belongs to the methyltransferase superfamily
AXG53_RS02995	COG0494	nUDIX hydrolase
AXG53_RS03025	COG1024	Enoyl-CoA hydratase
AXG53_RS03035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AXG53_RS03050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AXG53_RS03055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AXG53_RS03060	COG0573	inorganic phosphate transmembrane transporter activity
AXG53_RS03065	COG0581	inorganic phosphate transmembrane transporter activity
AXG53_RS03075	COG0704	Plays a role in the regulation of phosphate uptake
AXG53_RS03085	COG3220	belongs to the UPF0276 family
AXG53_RS03095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AXG53_RS03100	COG4251	negative regulation of phosphorylation
AXG53_RS03100	COG3706	GGDEF domain
AXG53_RS03100	COG2203	Gaf domain
AXG53_RS03100	COG5001	Diguanylate cyclase
AXG53_RS03110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXG53_RS03115	COG0557	exoribonuclease II activity
AXG53_RS03135	COG2814	Major facilitator Superfamily
AXG53_RS03140	COG1566	PFAM secretion protein HlyD family protein
AXG53_RS03165	COG2193	ferroxidase activity
AXG53_RS03180	COG0475	glutathione-regulated potassium exporter activity
AXG53_RS03185	COG0367	asparagine synthase
AXG53_RS03210	COG5001	Diguanylate cyclase
AXG53_RS03210	COG4251	negative regulation of phosphorylation
AXG53_RS03210	COG3706	GGDEF domain
AXG53_RS03210	COG2203	Gaf domain
AXG53_RS03220	COG1393	Belongs to the ArsC family
AXG53_RS03235	COG0024	Methionine aminopeptidase
AXG53_RS03250	COG3188	usher protein
AXG53_RS03280	COG0052	Belongs to the universal ribosomal protein uS2 family
AXG53_RS03295	COG0528	UMP kinase activity
AXG53_RS03300	COG0233	cytoplasmic translational termination
AXG53_RS03305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXG53_RS03310	COG0575	Belongs to the CDS family
AXG53_RS03315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AXG53_RS03320	COG0750	zinc metalloprotease
AXG53_RS03325	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AXG53_RS03330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXG53_RS03340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXG53_RS03370	COG0825	malonyl-CoA metabolic process
AXG53_RS03380	COG1981	membrane
AXG53_RS03445	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS03445	COG3321	synthase
AXG53_RS03445	COG0604	alcohol dehydrogenase
AXG53_RS03465	COG1132	(ABC) transporter
AXG53_RS03470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AXG53_RS03495	COG1187	pseudouridine synthase activity
AXG53_RS03500	COG2203	Gaf domain
AXG53_RS03500	COG2199	diguanylate cyclase activity
AXG53_RS03585	COG1228	amidohydrolase
AXG53_RS03590	COG0735	belongs to the Fur family
AXG53_RS03595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXG53_RS03615	COG4452	Inner membrane protein CreD
AXG53_RS03620	COG2205	protein histidine kinase activity
AXG53_RS03625	COG0745	RESPONSE REGULATOR receiver
AXG53_RS03630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AXG53_RS03640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AXG53_RS03680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AXG53_RS03700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AXG53_RS03705	COG1845	cytochrome c oxidase, subunit III
AXG53_RS03710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AXG53_RS03730	COG1012	belongs to the aldehyde dehydrogenase family
AXG53_RS03740	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AXG53_RS03745	COG0583	DNA-binding transcription factor activity
AXG53_RS03750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AXG53_RS03760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXG53_RS03765	COG0196	riboflavin kinase activity
AXG53_RS03770	COG0728	peptidoglycan biosynthetic process
AXG53_RS03780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXG53_RS03795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXG53_RS03800	COG0824	Thioesterase
AXG53_RS03820	COG1024	Enoyl-CoA hydratase
AXG53_RS03825	COG1946	Acyl-CoA thioesterase
AXG53_RS03835	COG1595	DNA-templated transcription, initiation
AXG53_RS03845	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AXG53_RS03860	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AXG53_RS03885	COG1073	alpha beta
AXG53_RS03900	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AXG53_RS03915	COG2197	response regulator
AXG53_RS03920	COG4585	Histidine kinase
AXG53_RS03930	COG0850	regulation of cytokinetic process
AXG53_RS03935	COG2894	cell division
AXG53_RS03950	COG2205	protein histidine kinase activity
AXG53_RS03955	COG0745	RESPONSE REGULATOR receiver
AXG53_RS03960	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AXG53_RS03970	COG2194	sulfuric ester hydrolase activity
AXG53_RS04005	COG4245	von Willebrand factor, type A
AXG53_RS04025	COG2814	Major facilitator Superfamily
AXG53_RS04030	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXG53_RS04030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXG53_RS04045	COG2207	Transcriptional regulator
AXG53_RS04045	COG1917	Cupin 2, conserved barrel domain protein
AXG53_RS04070	COG0330	HflC and HflK could
AXG53_RS04075	COG0330	HflC and HflK could
AXG53_RS04080	COG0604	alcohol dehydrogenase
AXG53_RS04100	COG0678	peroxiredoxin activity
AXG53_RS04110	COG4953	penicillin-binding protein 1C
AXG53_RS04115	COG2373	Large extracellular alpha-helical protein
AXG53_RS04125	COG2852	Protein conserved in bacteria
AXG53_RS04150	COG0372	Belongs to the citrate synthase family
AXG53_RS04195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AXG53_RS04205	COG2814	Major facilitator Superfamily
AXG53_RS04225	COG3038	cytochrome b561
AXG53_RS04255	COG0527	aspartate kinase activity
AXG53_RS04255	COG0460	homoserine dehydrogenase
AXG53_RS04260	COG0626	cystathionine gamma-synthase activity
AXG53_RS04265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXG53_RS04270	COG0739	heme binding
AXG53_RS04275	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AXG53_RS04280	COG1272	protein, Hemolysin III
AXG53_RS04285	COG2982	Protein involved in outer membrane biogenesis
AXG53_RS04290	COG0517	IMP dehydrogenase activity
AXG53_RS04295	COG0463	Glycosyl transferase, family 2
AXG53_RS04300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXG53_RS04305	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AXG53_RS04315	COG4206	TonB-dependent receptor
AXG53_RS04325	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
AXG53_RS04335	COG1309	transcriptional regulator
AXG53_RS04370	COG0501	Belongs to the peptidase M48B family
AXG53_RS04375	COG1704	LemA family
AXG53_RS04400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AXG53_RS04410	COG0330	HflC and HflK could
AXG53_RS04425	COG3956	TIGRFAM MazG family protein
AXG53_RS04430	COG1218	3'(2'),5'-bisphosphate nucleotidase
AXG53_RS04435	COG0494	nUDIX hydrolase
AXG53_RS04440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AXG53_RS04450	COG2201	protein-glutamate methylesterase activity
AXG53_RS04460	COG0840	transmembrane signaling receptor activity
AXG53_RS04465	COG0835	chemotaxis
AXG53_RS04480	COG0189	ligase activity
AXG53_RS04495	COG1199	ATP-dependent helicase activity
AXG53_RS04505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXG53_RS04520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXG53_RS04535	COG1643	Atp-dependent helicase
AXG53_RS04540	COG0783	Belongs to the Dps family
AXG53_RS04545	COG0514	ATP-dependent DNA helicase (RecQ)
AXG53_RS04570	COG0515	serine threonine protein kinase
AXG53_RS04570	COG2815	serine threonine protein kinase
AXG53_RS04590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AXG53_RS04595	COG0602	queuosine metabolic process
AXG53_RS04605	COG2885	chlorophyll binding
AXG53_RS04620	COG0848	biopolymer transport protein
AXG53_RS04630	COG0824	Thioesterase
AXG53_RS04635	COG2255	four-way junction helicase activity
AXG53_RS04645	COG0632	four-way junction helicase activity
AXG53_RS04650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AXG53_RS04665	COG4771	TonB-dependent receptor
AXG53_RS04670	COG1595	DNA-templated transcription, initiation
AXG53_RS04685	COG2963	transposase activity
AXG53_RS04695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXG53_RS04730	COG0488	(ABC) transporter
AXG53_RS04740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AXG53_RS04740	COG4651	solute:proton antiporter activity
AXG53_RS04755	COG2910	NAD(P)H-binding
AXG53_RS04765	COG0542	response to heat
AXG53_RS04805	COG3387	PFAM Glycoside hydrolase 15-related
AXG53_RS04810	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AXG53_RS04815	COG3011	Protein conserved in bacteria
AXG53_RS04830	COG0564	pseudouridine synthase activity
AXG53_RS04835	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AXG53_RS04840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AXG53_RS04840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXG53_RS04845	COG2852	Protein conserved in bacteria
AXG53_RS04855	COG0045	succinate-CoA ligase (ADP-forming) activity
AXG53_RS04880	COG1459	type II secretion system
AXG53_RS04885	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AXG53_RS04895	COG0642	Histidine kinase
AXG53_RS04900	COG0745	RESPONSE REGULATOR receiver
AXG53_RS04905	COG0189	ligase activity
AXG53_RS04925	COG2022	thiamine diphosphate biosynthetic process
AXG53_RS04935	COG0471	metal ion transport
AXG53_RS04935	COG3273	potassium ion transport
AXG53_RS04955	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXG53_RS04960	COG1970	mechanosensitive ion channel activity
AXG53_RS04980	COG1115	amino acid carrier protein
AXG53_RS04990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXG53_RS04995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXG53_RS05000	COG0529	Catalyzes the synthesis of activated sulfate
AXG53_RS05000	COG2895	sulfate adenylyltransferase (ATP) activity
AXG53_RS05010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AXG53_RS05020	COG0175	sulfate reduction
AXG53_RS05035	COG0583	DNA-binding transcription factor activity
AXG53_RS05050	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AXG53_RS05060	COG3588	fructose-bisphosphate aldolase
AXG53_RS05065	COG0469	pyruvate kinase activity
AXG53_RS05075	COG0126	phosphoglycerate kinase activity
AXG53_RS05080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AXG53_RS05095	COG1733	regulation of RNA biosynthetic process
AXG53_RS05105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AXG53_RS05125	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AXG53_RS05145	COG2885	chlorophyll binding
AXG53_RS05150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AXG53_RS05155	COG1301	dicarboxylic acid transport
AXG53_RS05185	COG0714	Associated with various cellular activities
AXG53_RS05215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AXG53_RS05230	COG0254	rRNA binding
AXG53_RS05235	COG1957	nucleoside hydrolase
AXG53_RS05240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AXG53_RS05275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXG53_RS05280	COG1758	RNA polymerase activity
AXG53_RS05290	COG1561	YicC-like family, N-terminal region
AXG53_RS05295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AXG53_RS05300	COG0346	lactoylglutathione lyase activity
AXG53_RS05315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXG53_RS05330	COG0006	proline dipeptidase activity
AXG53_RS05335	COG0006	proline dipeptidase activity
AXG53_RS05340	COG3079	Belongs to the UPF0149 family
AXG53_RS05360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXG53_RS05380	COG2912	Transglutaminase-like superfamily
AXG53_RS05385	COG1773	rubredoxin
AXG53_RS05395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXG53_RS05420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXG53_RS05425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXG53_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS05445	COG0671	phosphoesterase, PA-phosphatase related
AXG53_RS05455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXG53_RS05460	COG0563	adenylate kinase activity
AXG53_RS05475	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AXG53_RS05495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AXG53_RS05510	COG1917	Cupin 2, conserved barrel domain protein
AXG53_RS05510	COG4977	sequence-specific DNA binding
AXG53_RS05515	COG3710	Transcriptional regulator
AXG53_RS05530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AXG53_RS05535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXG53_RS05540	COG0405	Gamma-glutamyltransferase
AXG53_RS05560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXG53_RS05580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXG53_RS05585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AXG53_RS05595	COG0473	3-isopropylmalate dehydrogenase activity
AXG53_RS05600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AXG53_RS05625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AXG53_RS05630	COG1538	Outer membrane efflux protein
AXG53_RS05635	COG1519	Transferase
AXG53_RS05640	COG1560	Kdo2-lipid A biosynthetic process
AXG53_RS05660	COG0612	Peptidase, M16
AXG53_RS05675	COG0281	malic enzyme
AXG53_RS05675	COG0280	phosphate acetyltransferase
AXG53_RS05680	COG1301	dicarboxylic acid transport
AXG53_RS05685	COG4191	Histidine kinase
AXG53_RS05705	COG2610	gluconate transmembrane transporter activity
AXG53_RS05710	COG1737	Transcriptional regulator
AXG53_RS05715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AXG53_RS05725	COG0786	glutamate:sodium symporter activity
AXG53_RS05730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXG53_RS05745	COG0436	Aminotransferase
AXG53_RS05765	COG0513	Belongs to the DEAD box helicase family
AXG53_RS05775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AXG53_RS05785	COG1307	EDD domain protein, DegV family
AXG53_RS05800	COG2203	Gaf domain
AXG53_RS05800	COG3706	GGDEF domain
AXG53_RS05800	COG4251	negative regulation of phosphorylation
AXG53_RS05800	COG5001	Diguanylate cyclase
AXG53_RS05805	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AXG53_RS05810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AXG53_RS05875	COG3279	Response regulator of the LytR AlgR family
AXG53_RS05915	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AXG53_RS05950	COG0741	lytic transglycosylase activity
AXG53_RS05970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AXG53_RS05975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXG53_RS05980	COG1609	Transcriptional regulator
AXG53_RS05985	COG0738	Major facilitator superfamily
AXG53_RS05990	COG0837	glucose binding
AXG53_RS06000	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AXG53_RS06005	COG0837	glucose binding
AXG53_RS06025	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AXG53_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS06045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXG53_RS06055	COG0784	Response regulator, receiver
AXG53_RS06060	COG4251	negative regulation of phosphorylation
AXG53_RS06065	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AXG53_RS06085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AXG53_RS06090	COG0321	lipoyl(octanoyl) transferase activity
AXG53_RS06095	COG2921	Belongs to the UPF0250 family
AXG53_RS06110	COG1686	Belongs to the peptidase S11 family
AXG53_RS06115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AXG53_RS06120	COG2951	lytic endotransglycosylase activity
AXG53_RS06125	COG0772	Belongs to the SEDS family
AXG53_RS06130	COG0768	penicillin binding
AXG53_RS06135	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AXG53_RS06140	COG1792	Involved in formation and maintenance of cell shape
AXG53_RS06145	COG1077	Cell shape determining protein MreB Mrl
AXG53_RS06150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXG53_RS06155	COG0546	phosphoglycolate phosphatase activity
AXG53_RS06180	COG0308	aminopeptidase N
AXG53_RS06185	COG2226	methyltransferase
AXG53_RS06200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXG53_RS06205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXG53_RS06210	COG1309	transcriptional regulator
AXG53_RS06260	COG3451	type IV secretory pathway VirB4
AXG53_RS06270	COG3838	Conjugal transfer protein Trbc
AXG53_RS06275	COG4962	Type ii secretion system protein e
AXG53_RS06310	COG0583	DNA-binding transcription factor activity
AXG53_RS06320	COG1733	regulation of RNA biosynthetic process
AXG53_RS06325	COG0251	oxidation-reduction process
AXG53_RS06340	COG4959	Type IV secretory pathway protease TraF
AXG53_RS06390	COG5489	Protein of unknown function (DUF736)
AXG53_RS06410	COG2003	Belongs to the UPF0758 family
AXG53_RS06415	COG4804	nuclease activity
AXG53_RS06430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AXG53_RS06435	COG4245	von Willebrand factor, type A
AXG53_RS06500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AXG53_RS06510	COG4581	dead DEAH box helicase
AXG53_RS06530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AXG53_RS06540	COG2832	Protein of unknown function (DUF454)
AXG53_RS06550	COG0436	Aminotransferase
AXG53_RS06555	COG1505	serine-type exopeptidase activity
AXG53_RS06575	COG0339	signal peptide processing
AXG53_RS06580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AXG53_RS06590	COG2132	Multicopper oxidase
AXG53_RS06610	COG2871	sodium ion transport
AXG53_RS06645	COG1136	(ABC) transporter
AXG53_RS06650	COG0577	efflux transmembrane transporter activity
AXG53_RS06650	COG1136	(ABC) transporter
AXG53_RS06655	COG0577	efflux transmembrane transporter activity
AXG53_RS06660	COG0577	efflux transmembrane transporter activity
AXG53_RS06660	COG1136	(ABC) transporter
AXG53_RS06665	COG0577	efflux transmembrane transporter activity
AXG53_RS06670	COG0577	efflux transmembrane transporter activity
AXG53_RS06670	COG1136	(ABC) transporter
AXG53_RS06675	COG0577	efflux transmembrane transporter activity
AXG53_RS06690	COG2204	response regulator
AXG53_RS06695	COG4191	Histidine kinase
AXG53_RS06705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXG53_RS06715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AXG53_RS06730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXG53_RS06735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXG53_RS06740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXG53_RS06750	COG0356	it plays a direct role in the translocation of protons across the membrane
AXG53_RS06770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXG53_RS06780	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXG53_RS06790	COG3047	cAMP biosynthetic process
AXG53_RS06810	COG2011	ABC-type metal ion transport system permease component
AXG53_RS06820	COG0697	spore germination
AXG53_RS06850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AXG53_RS06855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AXG53_RS06880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AXG53_RS06950	COG3118	belongs to the thioredoxin family
AXG53_RS06955	COG0459	protein refolding
AXG53_RS06960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXG53_RS06975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXG53_RS06985	COG1053	succinate dehydrogenase
AXG53_RS07020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AXG53_RS07065	COG0393	Putative heavy-metal-binding
AXG53_RS07100	COG0583	DNA-binding transcription factor activity
AXG53_RS07120	COG0778	Nitroreductase
AXG53_RS07130	COG1666	GTP binding
AXG53_RS07155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXG53_RS07160	COG1187	pseudouridine synthase activity
AXG53_RS07165	COG2813	Specifically methylates the guanine in position
AXG53_RS07175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXG53_RS07175	COG2205	protein histidine kinase activity
AXG53_RS07190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXG53_RS07205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXG53_RS07240	COG0025	NhaP-type Na H and K H
AXG53_RS07245	COG3384	dioxygenase
AXG53_RS07260	COG3590	peptidase
AXG53_RS07285	COG3275	phosphorelay sensor kinase activity
AXG53_RS07300	COG4941	Belongs to the sigma-70 factor family
AXG53_RS07305	COG5507	3-demethylubiquinone-9 3-methyltransferase
AXG53_RS07315	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AXG53_RS07320	COG3795	YCII-related domain
AXG53_RS07325	COG3795	YCII-related domain
AXG53_RS07350	COG0741	lytic transglycosylase activity
AXG53_RS07375	COG0659	secondary active sulfate transmembrane transporter activity
AXG53_RS07415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXG53_RS07420	COG1490	D-aminoacyl-tRNA deacylase activity
AXG53_RS07430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXG53_RS07470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AXG53_RS07470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXG53_RS07475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXG53_RS07480	COG0242	peptide deformylase activity
AXG53_RS07490	COG0758	DNA mediated transformation
AXG53_RS07505	COG1714	RDD family
AXG53_RS07510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AXG53_RS07510	COG1754	DNA topoisomerase type I activity
AXG53_RS07515	COG0009	L-threonylcarbamoyladenylate synthase
AXG53_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS07545	COG0616	signal peptide processing
AXG53_RS07550	COG0534	Mate efflux family protein
AXG53_RS07565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AXG53_RS07570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AXG53_RS07580	COG3250	beta-galactosidase activity
AXG53_RS07590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXG53_RS07600	COG1609	Transcriptional regulator
AXG53_RS07605	COG3537	Alpha-1,2-mannosidase
AXG53_RS07615	COG0625	glutathione transferase activity
AXG53_RS07625	COG1252	NADH dehydrogenase
AXG53_RS07650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AXG53_RS07655	COG2201	protein-glutamate methylesterase activity
AXG53_RS07660	COG2177	Part of the ABC transporter FtsEX involved in
AXG53_RS07665	COG2884	Cell division ATP-binding protein ftsE
AXG53_RS07675	COG3118	belongs to the thioredoxin family
AXG53_RS07680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AXG53_RS07685	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AXG53_RS07715	COG1652	LysM domain
AXG53_RS07720	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AXG53_RS07720	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AXG53_RS07730	COG1473	amidohydrolase
AXG53_RS07735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXG53_RS07740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXG53_RS07745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXG53_RS07750	COG0753	catalase activity
AXG53_RS07755	COG3038	cytochrome b561
AXG53_RS07760	COG2197	response regulator
AXG53_RS07765	COG4585	Histidine kinase
AXG53_RS07775	COG1131	(ABC) transporter
AXG53_RS07780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXG53_RS07785	COG1136	(ABC) transporter
AXG53_RS07800	COG4206	TonB-dependent receptor
AXG53_RS07845	COG0739	heme binding
AXG53_RS07860	COG2223	nitrite transmembrane transporter activity
AXG53_RS07880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AXG53_RS07885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AXG53_RS07895	COG2205	protein histidine kinase activity
AXG53_RS07915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AXG53_RS07925	COG0018	arginyl-trna synthetase
AXG53_RS07940	COG4221	oxidoreductase activity
AXG53_RS07945	COG1166	arginine decarboxylase activity
AXG53_RS07970	COG2960	long-chain fatty acid transporting porin activity
AXG53_RS07975	COG0606	chelatase, subunit chli
AXG53_RS08020	COG2200	EAL domain
AXG53_RS08055	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AXG53_RS08055	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AXG53_RS08085	COG3135	benzoate transporter
AXG53_RS08090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXG53_RS08095	COG0659	secondary active sulfate transmembrane transporter activity
AXG53_RS08105	COG0431	NADPH-dependent FMN reductase
AXG53_RS08120	COG0798	PFAM Bile acid sodium symporter
AXG53_RS08125	COG0492	ferredoxin-NADP+ reductase activity
AXG53_RS08130	COG2072	flavoprotein involved in K transport
AXG53_RS08140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AXG53_RS08145	COG0573	inorganic phosphate transmembrane transporter activity
AXG53_RS08160	COG0704	Plays a role in the regulation of phosphate uptake
AXG53_RS08180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXG53_RS08230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AXG53_RS08265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AXG53_RS08270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXG53_RS08290	COG1704	LemA family
AXG53_RS08295	COG2183	response to ionizing radiation
AXG53_RS08315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXG53_RS08320	COG0668	transmembrane transport
AXG53_RS08325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AXG53_RS08400	COG3142	Participates in the control of copper homeostasis
AXG53_RS08405	COG1446	asparaginase
AXG53_RS08410	COG0837	glucose binding
AXG53_RS08415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AXG53_RS08420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXG53_RS08425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AXG53_RS08430	COG1674	ftsk spoiiie
AXG53_RS08435	COG0492	ferredoxin-NADP+ reductase activity
AXG53_RS08460	COG0542	response to heat
AXG53_RS08480	COG0482	sulfurtransferase activity
AXG53_RS08485	COG2915	High frequency lysogenization protein hflD homolog
AXG53_RS08510	COG5002	protein histidine kinase activity
AXG53_RS08530	COG0835	chemotaxis
AXG53_RS08530	COG0784	Response regulator, receiver
AXG53_RS08540	COG1558	bacterial-type flagellum-dependent cell motility
AXG53_RS08545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AXG53_RS08555	COG4787	bacterial-type flagellum-dependent cell motility
AXG53_RS08565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AXG53_RS08570	COG1706	bacterial-type flagellum-dependent cell motility
AXG53_RS08595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AXG53_RS08625	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AXG53_RS08630	COG2201	protein-glutamate methylesterase activity
AXG53_RS08640	COG0110	maltose O-acetyltransferase activity
AXG53_RS08645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXG53_RS08650	COG0463	Glycosyl transferase, family 2
AXG53_RS08650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXG53_RS08660	COG1215	transferase activity, transferring glycosyl groups
AXG53_RS08670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXG53_RS08675	COG0438	transferase activity, transferring glycosyl groups
AXG53_RS08675	COG1216	Glycosyl transferase, family 2
AXG53_RS08680	COG1677	Flagellar hook-basal body complex protein FliE
AXG53_RS08730	COG3190	flagellar
AXG53_RS08740	COG0587	DNA-directed DNA polymerase activity
AXG53_RS08755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AXG53_RS08760	COG3706	GGDEF domain
AXG53_RS08770	COG0415	Belongs to the DNA photolyase family
AXG53_RS08775	COG0305	Participates in initiation and elongation during chromosome replication
AXG53_RS08815	COG0583	DNA-binding transcription factor activity
AXG53_RS08820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXG53_RS08835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXG53_RS08840	COG0077	Prephenate dehydratase
AXG53_RS08840	COG1605	Chorismate mutase
AXG53_RS08845	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AXG53_RS08865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AXG53_RS08885	COG1228	amidohydrolase
AXG53_RS08890	COG2986	histidine ammonia-lyase
AXG53_RS08905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AXG53_RS08910	COG2259	Doxx family
AXG53_RS08920	COG2885	chlorophyll binding
AXG53_RS09045	COG2801	Transposase and inactivated derivatives
AXG53_RS09050	COG2963	transposase activity
AXG53_RS09075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AXG53_RS09085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXG53_RS09090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AXG53_RS09100	COG0505	Belongs to the CarA family
AXG53_RS09105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXG53_RS09130	COG1024	Enoyl-CoA hydratase
AXG53_RS09150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXG53_RS09180	COG0745	RESPONSE REGULATOR receiver
AXG53_RS09185	COG5002	protein histidine kinase activity
AXG53_RS09190	COG0277	FAD linked oxidase domain protein
AXG53_RS09195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXG53_RS09205	COG0531	amino acid
AXG53_RS09210	COG0531	amino acid
AXG53_RS09215	COG0235	Class ii aldolase
AXG53_RS09220	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AXG53_RS09225	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AXG53_RS09230	COG1285	pathogenesis
AXG53_RS09235	COG1408	metallophosphoesterase
AXG53_RS09245	COG0531	amino acid
AXG53_RS09255	COG1201	RNA secondary structure unwinding
AXG53_RS09260	COG1793	dna ligase
AXG53_RS09285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AXG53_RS09290	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AXG53_RS09320	COG2198	Histidine kinase
AXG53_RS09320	COG0784	Response regulator, receiver
AXG53_RS09320	COG0643	Histidine kinase
AXG53_RS09325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AXG53_RS09340	COG0835	chemotaxis
AXG53_RS09350	COG0745	RESPONSE REGULATOR receiver
AXG53_RS09360	COG0840	transmembrane signaling receptor activity
AXG53_RS09365	COG0840	transmembrane signaling receptor activity
AXG53_RS09370	COG0840	transmembrane signaling receptor activity
AXG53_RS09385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AXG53_RS09390	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AXG53_RS09395	COG0835	chemotaxis
AXG53_RS09405	COG0840	transmembrane signaling receptor activity
AXG53_RS09410	COG0840	transmembrane signaling receptor activity
AXG53_RS09440	COG2274	protein secretion by the type I secretion system
AXG53_RS09465	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AXG53_RS09475	COG0318	PFAM AMP-dependent synthetase and ligase
AXG53_RS09485	COG0140	phosphoribosyl-ATP diphosphatase activity
AXG53_RS09485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AXG53_RS09495	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AXG53_RS09500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXG53_RS09505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AXG53_RS09505	COG0131	Imidazoleglycerol-phosphate dehydratase
AXG53_RS09510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXG53_RS09515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AXG53_RS09520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXG53_RS09530	COG0124	histidyl-tRNA synthetase
AXG53_RS09535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXG53_RS09540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AXG53_RS09610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXG53_RS09725	COG1192	Involved in chromosome partitioning
AXG53_RS09770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXG53_RS09785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AXG53_RS09795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXG53_RS09835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXG53_RS09840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AXG53_RS09845	COG1012	belongs to the aldehyde dehydrogenase family
AXG53_RS09860	COG0167	dihydroorotate dehydrogenase activity
AXG53_RS09870	COG0697	spore germination
AXG53_RS09875	COG1346	cytolysis
AXG53_RS09885	COG0583	DNA-binding transcription factor activity
AXG53_RS09890	COG3539	Fimbrial protein
AXG53_RS09895	COG3121	Chaperone
AXG53_RS09900	COG3188	usher protein
AXG53_RS09910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXG53_RS09910	COG0519	Catalyzes the synthesis of GMP from XMP
AXG53_RS09920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXG53_RS09925	COG0475	glutathione-regulated potassium exporter activity
AXG53_RS09925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AXG53_RS09930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AXG53_RS09935	COG1160	GTP binding
AXG53_RS09940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AXG53_RS09945	COG2976	Protein conserved in bacteria
AXG53_RS09950	COG1426	Protein conserved in bacteria
AXG53_RS09960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXG53_RS09975	COG1024	Enoyl-CoA hydratase
AXG53_RS09975	COG1250	3-hydroxyacyl-CoA dehydrogenase
AXG53_RS09980	COG0183	Belongs to the thiolase family
AXG53_RS10000	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AXG53_RS10010	COG0776	regulation of translation
AXG53_RS10020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AXG53_RS10035	COG2957	Belongs to the agmatine deiminase family
AXG53_RS10040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXG53_RS10045	COG1247	-acetyltransferase
AXG53_RS10055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXG53_RS10085	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AXG53_RS10085	COG0316	Belongs to the HesB IscA family
AXG53_RS10090	COG2154	pterin-4-alpha-carbinolamine dehydratase
AXG53_RS10100	COG0428	transporter
AXG53_RS10110	COG1530	ribonuclease E activity
AXG53_RS10120	COG0671	phosphoesterase, PA-phosphatase related
AXG53_RS10125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AXG53_RS10135	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AXG53_RS10140	COG0166	Belongs to the GPI family
AXG53_RS10145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AXG53_RS10150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AXG53_RS10155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AXG53_RS10165	COG0617	tRNA 3'-terminal CCA addition
AXG53_RS10175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AXG53_RS10185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXG53_RS10195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AXG53_RS10200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AXG53_RS10215	COG0351	phosphomethylpyrimidine kinase
AXG53_RS10240	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AXG53_RS10245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXG53_RS10250	COG2137	regulation of response to DNA damage stimulus
AXG53_RS10255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AXG53_RS10260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AXG53_RS10265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AXG53_RS10270	COG1546	Belongs to the CinA family
AXG53_RS10275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXG53_RS10285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXG53_RS10290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXG53_RS10300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXG53_RS10305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AXG53_RS10310	COG1534	Rna-binding protein
AXG53_RS10325	COG1238	metal cluster binding
AXG53_RS10335	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AXG53_RS10340	COG2840	Smr protein MutS2
AXG53_RS10355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AXG53_RS10360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AXG53_RS10365	COG0148	phosphopyruvate hydratase activity
AXG53_RS10370	COG0504	CTP synthase activity
AXG53_RS10385	COG0306	phosphate transporter
AXG53_RS10395	COG1253	flavin adenine dinucleotide binding
AXG53_RS10405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXG53_RS10430	COG0069	glutamate synthase activity
AXG53_RS10435	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AXG53_RS10440	COG2200	EAL domain
AXG53_RS10520	COG0322	excinuclease ABC activity
AXG53_RS10530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXG53_RS10535	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AXG53_RS10540	COG1663	tetraacyldisaccharide 4'-kinase activity
AXG53_RS10550	COG0848	biopolymer transport protein
AXG53_RS10565	COG1185	polyribonucleotide nucleotidyltransferase activity
AXG53_RS10570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AXG53_RS10580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXG53_RS10585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXG53_RS10590	COG0195	Participates in both transcription termination and antitermination
AXG53_RS10595	COG0779	Required for maturation of 30S ribosomal subunits
AXG53_RS10605	COG1007	ATP synthesis coupled electron transport
AXG53_RS10640	COG1034	ATP synthesis coupled electron transport
AXG53_RS10650	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AXG53_RS10655	COG0649	NAD binding
AXG53_RS10660	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXG53_RS10665	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXG53_RS10670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXG53_RS10685	COG0149	triose-phosphate isomerase activity
AXG53_RS10695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXG53_RS10700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AXG53_RS10705	COG0159	tryptophan synthase activity
AXG53_RS10715	COG0133	tryptophan synthase activity
AXG53_RS10735	COG2255	four-way junction helicase activity
AXG53_RS10750	COG0135	phosphoribosylanthranilate isomerase activity
AXG53_RS10770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AXG53_RS10775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXG53_RS10780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXG53_RS10785	COG2890	protein-(glutamine-N5) methyltransferase activity
AXG53_RS10795	COG0688	phosphatidylethanolamine metabolic process
AXG53_RS10805	COG0433	COG0433 Predicted ATPase
AXG53_RS10820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXG53_RS10830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXG53_RS10835	COG0412	Dienelactone hydrolase
AXG53_RS10845	COG0717	Belongs to the dCTP deaminase family
AXG53_RS10850	COG0489	protein tyrosine kinase activity
AXG53_RS10875	COG3590	peptidase
AXG53_RS10895	COG0697	spore germination
AXG53_RS10905	COG2311	Membrane
AXG53_RS10915	COG0791	NLP P60 protein
AXG53_RS10920	COG0791	NLP P60 protein
AXG53_RS10925	COG2204	response regulator
AXG53_RS10960	COG1301	dicarboxylic acid transport
AXG53_RS10980	COG1722	exodeoxyribonuclease VII activity
AXG53_RS10985	COG0142	geranyltranstransferase activity
AXG53_RS10995	COG0312	modulator of DNA gyrase
AXG53_RS11000	COG3028	Belongs to the UPF0307 family
AXG53_RS11005	COG0312	modulator of DNA gyrase
AXG53_RS11045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AXG53_RS11055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AXG53_RS11070	COG0495	leucyl-tRNA aminoacylation
AXG53_RS11115	COG4964	Belongs to the GSP D family
AXG53_RS11160	COG3118	belongs to the thioredoxin family
AXG53_RS11170	COG2203	Gaf domain
AXG53_RS11170	COG3706	GGDEF domain
AXG53_RS11170	COG5001	Diguanylate cyclase
AXG53_RS11170	COG4251	negative regulation of phosphorylation
AXG53_RS11195	COG0346	lactoylglutathione lyase activity
AXG53_RS11205	COG1131	(ABC) transporter
AXG53_RS11220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXG53_RS11220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXG53_RS11230	COG2878	Part of a membrane complex involved in electron transport
AXG53_RS11245	COG0392	lysyltransferase activity
AXG53_RS11245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AXG53_RS11275	COG2824	Alkylphosphonate utilization operon protein PhnA
AXG53_RS11285	COG1077	Cell shape determining protein MreB Mrl
AXG53_RS11300	COG1595	DNA-templated transcription, initiation
AXG53_RS11325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AXG53_RS11330	COG3122	Protein conserved in bacteria
AXG53_RS11335	COG1451	nucleotide metabolic process
AXG53_RS11355	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AXG53_RS11360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXG53_RS11390	COG5001	Diguanylate cyclase
AXG53_RS11390	COG3300	MHYT domain
AXG53_RS11425	COG0204	Acyl-transferase
AXG53_RS11435	COG3300	MHYT domain
AXG53_RS11435	COG5001	Diguanylate cyclase
AXG53_RS11450	COG1619	proteins homologs of microcin C7 resistance protein MccF
AXG53_RS11455	COG1703	isobutyryl-CoA mutase activity
AXG53_RS11455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AXG53_RS11455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AXG53_RS11470	COG0183	Belongs to the thiolase family
AXG53_RS11490	COG1960	acyl-CoA dehydrogenase activity
AXG53_RS11495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXG53_RS11500	COG1278	Cold shock
AXG53_RS11505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AXG53_RS11510	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AXG53_RS11515	COG1472	Belongs to the glycosyl hydrolase 3 family
AXG53_RS11520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AXG53_RS11525	COG2954	triphosphatase activity
AXG53_RS11530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXG53_RS11535	COG2198	Histidine kinase
AXG53_RS11535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXG53_RS11535	COG0784	Response regulator, receiver
AXG53_RS11535	COG2205	protein histidine kinase activity
AXG53_RS11540	COG1381	Involved in DNA repair and RecF pathway recombination
AXG53_RS11545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXG53_RS11560	COG0681	Belongs to the peptidase S26 family
AXG53_RS11565	COG0481	GTPase activity
AXG53_RS11570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXG53_RS11600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXG53_RS11605	COG3706	GGDEF domain
AXG53_RS11620	COG0531	amino acid
AXG53_RS11635	COG0531	amino acid
AXG53_RS11640	COG4771	TonB-dependent receptor
AXG53_RS11645	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AXG53_RS11650	COG0625	glutathione transferase activity
AXG53_RS11655	COG2378	regulation of single-species biofilm formation
AXG53_RS11660	COG0753	catalase activity
AXG53_RS11670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AXG53_RS11675	COG0534	Mate efflux family protein
AXG53_RS11680	COG0673	inositol 2-dehydrogenase activity
AXG53_RS11695	COG2222	sugar isomerase
AXG53_RS11700	COG1940	carbohydrate kinase activity
AXG53_RS11710	COG1349	DNA-binding transcription factor activity
AXG53_RS11720	COG2814	Major facilitator Superfamily
AXG53_RS11725	COG0335	large ribosomal subunit rRNA binding
AXG53_RS11730	COG0336	Belongs to the RNA methyltransferase TrmD family
AXG53_RS11735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXG53_RS11750	COG0024	Methionine aminopeptidase
AXG53_RS11755	COG3590	peptidase
AXG53_RS11770	COG4221	oxidoreductase activity
AXG53_RS11775	COG2223	nitrite transmembrane transporter activity
AXG53_RS11780	COG2223	nitrite transmembrane transporter activity
AXG53_RS11785	COG2207	Transcriptional regulator
AXG53_RS11815	COG0588	phosphoglycerate mutase activity
AXG53_RS11820	COG1741	Belongs to the pirin family
AXG53_RS11835	COG1741	Belongs to the pirin family
AXG53_RS11840	COG1966	Carbon starvation protein
AXG53_RS11845	COG2879	small protein
AXG53_RS11865	COG1506	peptidase
AXG53_RS11865	COG0823	Involved in the tonB-independent uptake of proteins
AXG53_RS11870	COG1297	OPT oligopeptide transporter protein
AXG53_RS11875	COG3104	oligopeptide transport
AXG53_RS11880	COG1280	lysine exporter protein (LysE YggA)
AXG53_RS11895	COG3210	domain, Protein
AXG53_RS11895	COG3210	domain, Protein
AXG53_RS11900	COG2831	hemolysin activation secretion protein
AXG53_RS11905	COG1609	Transcriptional regulator
AXG53_RS11915	COG2211	Major facilitator Superfamily
AXG53_RS11920	COG0673	inositol 2-dehydrogenase activity
AXG53_RS11955	COG0629	single-stranded DNA binding
AXG53_RS11960	COG1609	Transcriptional regulator
AXG53_RS11975	COG2211	Major facilitator Superfamily
AXG53_RS11975	COG2190	(PTS) system
AXG53_RS11980	COG1082	Xylose isomerase domain protein TIM barrel
AXG53_RS11995	COG0366	Alpha amylase catalytic
AXG53_RS12000	COG0142	geranyltranstransferase activity
AXG53_RS12015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXG53_RS12025	COG0527	aspartate kinase activity
AXG53_RS12035	COG0384	phenazine biosynthesis protein PhzF
AXG53_RS12040	COG0384	phenazine biosynthesis protein PhzF
AXG53_RS12070	COG4771	TonB-dependent receptor
AXG53_RS12075	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AXG53_RS12085	COG1764	response to oxidative stress
AXG53_RS12110	COG1959	2 iron, 2 sulfur cluster binding
AXG53_RS12115	COG0719	Fe-S assembly protein
AXG53_RS12125	COG0396	ATPase activity
AXG53_RS12130	COG0719	Fe-S assembly protein
AXG53_RS12135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AXG53_RS12155	COG4774	siderophore transport
AXG53_RS12165	COG3128	pkhd-type hydroxylase
AXG53_RS12175	COG4771	TonB-dependent receptor
AXG53_RS12195	COG1477	protein flavinylation
AXG53_RS12200	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AXG53_RS12215	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS12240	COG0640	Transcriptional regulator
AXG53_RS12245	COG2205	protein histidine kinase activity
AXG53_RS12255	COG4771	TonB-dependent receptor
AXG53_RS12260	COG2610	gluconate transmembrane transporter activity
AXG53_RS12265	COG1555	photosystem II stabilization
AXG53_RS12285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AXG53_RS12295	COG0628	permease
AXG53_RS12305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXG53_RS12315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AXG53_RS12335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXG53_RS12350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AXG53_RS12360	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AXG53_RS12365	COG1137	ATPase activity
AXG53_RS12380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXG53_RS12385	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AXG53_RS12390	COG1660	Displays ATPase and GTPase activities
AXG53_RS12400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXG53_RS12405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXG53_RS12410	COG2239	Acts as a magnesium transporter
AXG53_RS12430	COG0540	Belongs to the ATCase OTCase family
AXG53_RS12440	COG1678	Uncharacterized ACR, COG1678
AXG53_RS12445	COG0519	Catalyzes the synthesis of GMP from XMP
AXG53_RS12460	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AXG53_RS12535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AXG53_RS12540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXG53_RS12560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AXG53_RS12565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXG53_RS12570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AXG53_RS12575	COG1399	metal-binding, possibly nucleic acid-binding protein
AXG53_RS12590	COG0714	Associated with various cellular activities
AXG53_RS12595	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AXG53_RS12610	COG0537	adenosine 5'-monophosphoramidase activity
AXG53_RS12625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AXG53_RS12655	COG2336	PFAM SpoVT AbrB
AXG53_RS12660	COG3537	Alpha-1,2-mannosidase
AXG53_RS12680	COG1234	tRNA 3'-trailer cleavage
AXG53_RS12685	COG3642	lipopolysaccharide core region biosynthetic process
AXG53_RS12690	COG0859	PFAM glycosyl transferase family 9
AXG53_RS12700	COG0582	viral genome integration into host DNA
AXG53_RS12705	COG4716	Myosin-crossreactive antigen
AXG53_RS12720	COG2801	Transposase and inactivated derivatives
AXG53_RS12725	COG2963	transposase activity
AXG53_RS12750	COG2801	Transposase and inactivated derivatives
AXG53_RS12795	COG2003	Belongs to the UPF0758 family
AXG53_RS12810	COG1393	Belongs to the ArsC family
AXG53_RS12815	COG0431	NADPH-dependent FMN reductase
AXG53_RS12830	COG0798	PFAM Bile acid sodium symporter
AXG53_RS12855	COG3038	cytochrome b561
AXG53_RS12865	COG0642	Histidine kinase
AXG53_RS12885	COG0640	Transcriptional regulator
AXG53_RS12890	COG0346	lactoylglutathione lyase activity
AXG53_RS12900	COG0798	PFAM Bile acid sodium symporter
AXG53_RS12905	COG1393	Belongs to the ArsC family
AXG53_RS12945	COG2801	Transposase and inactivated derivatives
AXG53_RS12950	COG2963	transposase activity
AXG53_RS12960	COG5377	YqaJ viral recombinase family
AXG53_RS12965	COG2003	Belongs to the UPF0758 family
AXG53_RS12980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AXG53_RS13005	COG0582	viral genome integration into host DNA
AXG53_RS13015	COG0631	protein serine/threonine phosphatase activity
AXG53_RS13020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AXG53_RS13030	COG2226	methyltransferase
AXG53_RS13035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXG53_RS13045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXG53_RS13080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXG53_RS13085	COG0740	serine-type endopeptidase activity
AXG53_RS13090	COG0544	peptidyl-prolyl cis-trans isomerase activity
AXG53_RS13130	COG0473	3-isopropylmalate dehydrogenase activity
AXG53_RS13145	COG4783	chaperone-mediated protein folding
AXG53_RS13160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AXG53_RS13165	COG0248	Ppx GppA phosphatase
AXG53_RS13170	COG0438	transferase activity, transferring glycosyl groups
AXG53_RS13180	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXG53_RS13190	COG2833	Protein of unknown function (DUF455)
AXG53_RS13210	COG0285	dihydrofolate synthase activity
AXG53_RS13215	COG0406	alpha-ribazole phosphatase activity
AXG53_RS13230	COG1063	alcohol dehydrogenase
AXG53_RS13240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AXG53_RS13245	COG4208	sulfate ABC transporter
AXG53_RS13250	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AXG53_RS13255	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AXG53_RS13275	COG1187	pseudouridine synthase activity
AXG53_RS13305	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXG53_RS13305	COG1902	pentaerythritol trinitrate reductase activity
AXG53_RS13315	COG0625	glutathione transferase activity
AXG53_RS13320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXG53_RS13335	COG0745	RESPONSE REGULATOR receiver
AXG53_RS13340	COG5002	protein histidine kinase activity
AXG53_RS13355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AXG53_RS13370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXG53_RS13385	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AXG53_RS13390	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AXG53_RS13395	COG0203	ribosomal protein L17
AXG53_RS13400	COG0202	RNA polymerase activity
AXG53_RS13405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXG53_RS13415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXG53_RS13420	COG0201	protein transport
AXG53_RS13430	COG1841	ribosomal large subunit assembly
AXG53_RS13435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AXG53_RS13440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AXG53_RS13445	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXG53_RS13450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AXG53_RS13455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXG53_RS13460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXG53_RS13465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXG53_RS13475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXG53_RS13480	COG0255	Belongs to the universal ribosomal protein uL29 family
AXG53_RS13485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXG53_RS13490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXG53_RS13495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXG53_RS13500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXG53_RS13505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXG53_RS13510	COG0089	rRNA binding
AXG53_RS13515	COG0088	Forms part of the polypeptide exit tunnel
AXG53_RS13520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXG53_RS13525	COG0051	transcription antitermination factor activity, RNA binding
AXG53_RS13530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXG53_RS13535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXG53_RS13540	COG0049	tRNA binding
AXG53_RS13545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXG53_RS13550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXG53_RS13555	COG0085	RNA polymerase activity
AXG53_RS13560	COG0222	ribosome binding
AXG53_RS13565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AXG53_RS13570	COG0081	regulation of translation
AXG53_RS13575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AXG53_RS13580	COG0250	Participates in transcription elongation, termination and antitermination
AXG53_RS13595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXG53_RS13615	COG1446	asparaginase
AXG53_RS13620	COG3340	Belongs to the peptidase S51 family
AXG53_RS13630	COG0012	GTP binding
AXG53_RS13635	COG0193	aminoacyl-tRNA hydrolase activity
AXG53_RS13640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXG53_RS13645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXG53_RS13655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AXG53_RS13660	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AXG53_RS13670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AXG53_RS13675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXG53_RS13690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXG53_RS13695	COG1295	ribonuclease BN
AXG53_RS13715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AXG53_RS13720	COG1404	Belongs to the peptidase S8 family
AXG53_RS13725	COG1404	Belongs to the peptidase S8 family
AXG53_RS13730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AXG53_RS13735	COG2151	metal-sulfur cluster biosynthetic enzyme
AXG53_RS13755	COG0457	Tetratricopeptide repeat
AXG53_RS13765	COG2207	Transcriptional regulator
AXG53_RS13800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AXG53_RS13810	COG0778	Nitroreductase
AXG53_RS13850	COG3634	alkyl hydroperoxide reductase activity
AXG53_RS13855	COG0583	DNA-binding transcription factor activity
AXG53_RS13860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXG53_RS13875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXG53_RS13890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXG53_RS13905	COG0642	Histidine kinase
AXG53_RS13920	COG2851	Citrate transporter
AXG53_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS13940	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AXG53_RS13960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AXG53_RS13965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXG53_RS13970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXG53_RS13980	COG2096	Adenosyltransferase
AXG53_RS13990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AXG53_RS13995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXG53_RS14000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AXG53_RS14005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXG53_RS14010	COG2967	ApaG domain
AXG53_RS14015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AXG53_RS14020	COG3738	Protein conserved in bacteria
AXG53_RS14055	COG0861	Integral membrane protein TerC family
AXG53_RS14060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AXG53_RS14085	COG4771	TonB-dependent receptor
AXG53_RS14095	COG0667	Aldo Keto reductase
AXG53_RS14100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AXG53_RS14110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AXG53_RS14120	COG4106	trans-aconitate 2-methyltransferase activity
AXG53_RS14140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXG53_RS14160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXG53_RS14180	COG4589	Belongs to the CDS family
AXG53_RS14185	COG1607	acyl-coa hydrolase
AXG53_RS14190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AXG53_RS14200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AXG53_RS14280	COG0531	amino acid
AXG53_RS14290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AXG53_RS14300	COG0494	nUDIX hydrolase
AXG53_RS14305	COG0653	protein targeting
AXG53_RS14310	COG0739	heme binding
AXG53_RS14320	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AXG53_RS14335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AXG53_RS14345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXG53_RS14355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXG53_RS14360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXG53_RS14375	COG3116	cell division
AXG53_RS14380	COG0275	rRNA processing
AXG53_RS14385	COG2001	Belongs to the MraZ family
AXG53_RS14415	COG0792	nuclease activity
AXG53_RS14420	COG1988	membrane-bound metal-dependent
AXG53_RS14425	COG0277	FAD linked oxidase domain protein
AXG53_RS14455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXG53_RS14460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXG53_RS14480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXG53_RS14480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXG53_RS14500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXG53_RS14525	COG0488	(ABC) transporter
AXG53_RS14530	COG2252	PERMEase
AXG53_RS14555	COG3539	Fimbrial protein
AXG53_RS14565	COG0728	peptidoglycan biosynthetic process
AXG53_RS14620	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AXG53_RS14635	COG1450	Type ii and iii secretion system protein
AXG53_RS14650	COG3166	PFAM Fimbrial assembly family protein
AXG53_RS14655	COG3156	type II secretion system protein K
AXG53_RS14660	COG4795	General secretion pathway protein
AXG53_RS14665	COG2165	general secretion pathway protein
AXG53_RS14670	COG4970	Tfp pilus assembly protein FimT
AXG53_RS14675	COG2165	general secretion pathway protein
AXG53_RS14680	COG1459	type II secretion system
AXG53_RS14685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AXG53_RS14690	COG1404	Belongs to the peptidase S8 family
AXG53_RS14700	COG1404	Belongs to the peptidase S8 family
AXG53_RS14710	COG5295	Hep Hag repeat protein
AXG53_RS14715	COG0047	phosphoribosylformylglycinamidine synthase activity
AXG53_RS14715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AXG53_RS14725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXG53_RS14730	COG4974	Belongs to the 'phage' integrase family
AXG53_RS14740	COG0795	lipopolysaccharide-transporting ATPase activity
AXG53_RS14750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AXG53_RS14765	COG0525	valine-tRNA ligase activity
AXG53_RS14785	COG1183	phosphatidylcholine synthase activity
AXG53_RS14795	COG0442	prolyl-tRNA aminoacylation
AXG53_RS14810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AXG53_RS14815	COG1127	ABC transporter
AXG53_RS14820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AXG53_RS14820	COG3218	ABC-type transport auxiliary lipoprotein component
AXG53_RS14850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXG53_RS14890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AXG53_RS14895	COG0463	Glycosyl transferase, family 2
AXG53_RS14910	COG0110	maltose O-acetyltransferase activity
AXG53_RS14920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXG53_RS14940	COG0438	transferase activity, transferring glycosyl groups
AXG53_RS14955	COG0626	cystathionine gamma-synthase activity
AXG53_RS14985	COG0625	glutathione transferase activity
AXG53_RS14995	COG0513	Belongs to the DEAD box helicase family
AXG53_RS15005	COG4206	TonB-dependent receptor
AXG53_RS15010	COG0720	synthase
AXG53_RS15020	COG1956	GAF domain-containing protein
AXG53_RS15030	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AXG53_RS15040	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AXG53_RS15045	COG4206	TonB-dependent receptor
AXG53_RS15055	COG0546	phosphoglycolate phosphatase activity
AXG53_RS15060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXG53_RS15085	COG0181	hydroxymethylbilane synthase activity
AXG53_RS15105	COG3237	CsbD-like
AXG53_RS15110	COG2409	Drug exporters of the RND superfamily
AXG53_RS15165	COG3214	Protein conserved in bacteria
AXG53_RS15195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AXG53_RS15200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AXG53_RS15215	COG2375	cellular response to nickel ion
AXG53_RS15235	COG0339	signal peptide processing
AXG53_RS15285	COG0564	pseudouridine synthase activity
AXG53_RS15300	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXG53_RS15305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AXG53_RS15310	COG2852	Protein conserved in bacteria
AXG53_RS15315	COG0318	PFAM AMP-dependent synthetase and ligase
AXG53_RS15330	COG0596	Alpha beta hydrolase
AXG53_RS15335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXG53_RS15345	COG0612	Peptidase, M16
AXG53_RS15355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AXG53_RS15365	COG0154	amidase activity
AXG53_RS15385	COG0427	acetyl-CoA hydrolase
AXG53_RS15400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXG53_RS15415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXG53_RS15420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AXG53_RS15430	COG1845	cytochrome c oxidase, subunit III
AXG53_RS15435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AXG53_RS15440	COG1999	signal sequence binding
AXG53_RS15490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXG53_RS15500	COG3119	arylsulfatase activity
AXG53_RS15505	COG0604	alcohol dehydrogenase
AXG53_RS15505	COG3321	synthase
AXG53_RS15505	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS15510	COG1764	response to oxidative stress
AXG53_RS15520	COG1309	transcriptional regulator
AXG53_RS15525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AXG53_RS15535	COG0511	ligase activity, forming carbon-carbon bonds
AXG53_RS15540	COG0439	Biotin carboxylase
AXG53_RS15555	COG2264	protein methyltransferase activity
AXG53_RS15565	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AXG53_RS15585	COG0151	Belongs to the GarS family
AXG53_RS15590	COG0667	Aldo Keto reductase
AXG53_RS15600	COG1289	transmembrane transporter activity
AXG53_RS15605	COG2814	Major facilitator Superfamily
AXG53_RS15645	COG0316	Belongs to the HesB IscA family
AXG53_RS15685	COG1051	belongs to the nudix hydrolase family
AXG53_RS15705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AXG53_RS15710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXG53_RS15715	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AXG53_RS15725	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AXG53_RS15730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXG53_RS15735	COG0730	response to heat
AXG53_RS15745	COG0134	indole-3-glycerol-phosphate synthase activity
AXG53_RS15750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXG53_RS15760	COG1280	lysine exporter protein (LysE YggA)
AXG53_RS15765	COG0512	Glutamine amidotransferase of anthranilate synthase
AXG53_RS15780	COG1597	lipid kinase activity
AXG53_RS15795	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AXG53_RS15800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXG53_RS15810	COG2111	Na H antiporter
AXG53_RS15810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AXG53_RS15815	COG1006	Multisubunit Na H antiporter MnhC subunit
AXG53_RS15820	COG0651	ATP synthesis coupled electron transport
AXG53_RS15830	COG2212	antiporter activity
AXG53_RS15835	COG1320	monovalent cation:proton antiporter activity
AXG53_RS15840	COG0530	calcium, potassium:sodium antiporter activity
AXG53_RS15855	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AXG53_RS15860	COG2852	Protein conserved in bacteria
AXG53_RS15885	COG3104	oligopeptide transport
AXG53_RS15890	COG3483	tryptophan 2,3-dioxygenase activity
AXG53_RS15895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AXG53_RS15935	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS15940	COG0702	epimerase
AXG53_RS15960	COG2354	Protein conserved in bacteria
AXG53_RS15965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AXG53_RS15970	COG1368	sulfuric ester hydrolase activity
AXG53_RS15975	COG1196	nuclear chromosome segregation
AXG53_RS15975	COG3264	Mechanosensitive ion channel
AXG53_RS15990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXG53_RS15990	COG0723	plastoquinol--plastocyanin reductase activity
AXG53_RS16005	COG4807	Protein conserved in bacteria
AXG53_RS16020	COG0789	Transcriptional regulator
AXG53_RS16050	COG5507	3-demethylubiquinone-9 3-methyltransferase
AXG53_RS16060	COG4260	virion core protein, lumpy skin disease virus
AXG53_RS16065	COG4993	Dehydrogenase
AXG53_RS16130	COG1902	pentaerythritol trinitrate reductase activity
AXG53_RS16150	COG1943	Transposase
AXG53_RS16180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXG53_RS16200	COG0628	permease
AXG53_RS16210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AXG53_RS16215	COG5383	Protein conserved in bacteria
AXG53_RS16265	COG4948	Mandelate Racemase Muconate Lactonizing
AXG53_RS16275	COG1737	Transcriptional regulator
AXG53_RS16290	COG4682	membrane
AXG53_RS16295	COG2133	pyrroloquinoline quinone binding
AXG53_RS16310	COG0668	transmembrane transport
AXG53_RS16315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AXG53_RS16320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AXG53_RS16330	COG1610	YqeY-like protein
AXG53_RS16340	COG0358	DNA primase activity
AXG53_RS16380	COG1845	cytochrome c oxidase, subunit III
AXG53_RS16390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AXG53_RS16395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AXG53_RS16420	COG0793	Belongs to the peptidase S41A family
AXG53_RS16425	COG4942	peptidase
AXG53_RS16450	COG0697	spore germination
AXG53_RS16455	COG0477	Major facilitator Superfamily
AXG53_RS16475	COG0180	Tryptophanyl-tRNA synthetase
AXG53_RS16485	COG3237	CsbD-like
AXG53_RS16510	COG0517	IMP dehydrogenase activity
AXG53_RS16530	COG3437	response regulator, receiver
AXG53_RS16545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AXG53_RS16550	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AXG53_RS16550	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AXG53_RS16580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AXG53_RS16595	COG2076	Multidrug Resistance protein
AXG53_RS16605	COG1335	isochorismatase
AXG53_RS16620	COG0583	DNA-binding transcription factor activity
AXG53_RS16625	COG1902	pentaerythritol trinitrate reductase activity
AXG53_RS16635	COG1607	acyl-coa hydrolase
AXG53_RS16640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXG53_RS16660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AXG53_RS16670	COG0697	spore germination
AXG53_RS16690	COG1960	acyl-CoA dehydrogenase activity
AXG53_RS16695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXG53_RS16730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AXG53_RS16735	COG0583	DNA-binding transcription factor activity
AXG53_RS16740	COG0583	DNA-binding transcription factor activity
AXG53_RS16745	COG2814	Major facilitator Superfamily
AXG53_RS16755	COG0277	FAD linked oxidase domain protein
AXG53_RS16760	COG1304	FMN binding
AXG53_RS16765	COG2186	Transcriptional regulator
AXG53_RS16775	COG0681	Belongs to the peptidase S26 family
AXG53_RS16810	COG0277	FAD linked oxidase domain protein
AXG53_RS16820	COG2130	NADP-dependent
AXG53_RS16825	COG1960	acyl-CoA dehydrogenase activity
AXG53_RS16885	COG1113	amino acid transport
AXG53_RS16910	COG1199	ATP-dependent helicase activity
AXG53_RS16920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXG53_RS16940	COG3781	membrane
AXG53_RS16965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXG53_RS17005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AXG53_RS17025	COG0318	PFAM AMP-dependent synthetase and ligase
AXG53_RS17030	COG1294	oxidase, subunit
AXG53_RS17035	COG1271	oxidase subunit
AXG53_RS17060	COG0408	coproporphyrinogen oxidase activity
AXG53_RS17065	COG2323	membrane
AXG53_RS17080	COG0589	response to stress
AXG53_RS17085	COG0210	DNA helicase
AXG53_RS17095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXG53_RS17100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXG53_RS17110	COG1819	glycosyl
AXG53_RS17115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXG53_RS17140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXG53_RS17165	COG0463	Glycosyl transferase, family 2
AXG53_RS17185	COG1475	DNA binding
AXG53_RS17190	COG1192	Involved in chromosome partitioning
AXG53_RS17200	COG0357	Ribosomal RNA small subunit methyltransferase G
AXG53_RS17220	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AXG53_RS17235	COG0732	type I restriction modification DNA specificity domain
AXG53_RS17245	COG4735	regulation of single-species biofilm formation
AXG53_RS17250	COG2301	Belongs to the HpcH HpaI aldolase family
AXG53_RS17255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXG53_RS17260	COG0583	DNA-binding transcription factor activity
AXG53_RS17265	COG4774	siderophore transport
AXG53_RS17280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXG53_RS17290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXG53_RS17305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXG53_RS17330	COG1971	Probably functions as a manganese efflux pump
AXG53_RS17335	COG2205	protein histidine kinase activity
AXG53_RS17335	COG0784	Response regulator, receiver
AXG53_RS17365	COG2911	Protein conserved in bacteria
AXG53_RS17370	COG0729	surface antigen
AXG53_RS17375	COG4771	TonB-dependent receptor
AXG53_RS17380	COG0457	Tetratricopeptide repeat
AXG53_RS17395	COG0752	glycyl-tRNA synthetase alpha subunit
AXG53_RS17400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AXG53_RS17405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXG53_RS17405	COG0519	Catalyzes the synthesis of GMP from XMP
AXG53_RS17425	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AXG53_RS17435	COG0805	protein transport
AXG53_RS17455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXG53_RS17465	COG0840	transmembrane signaling receptor activity
AXG53_RS17475	COG2974	May be involved in recombination
AXG53_RS17480	COG0037	tRNA processing
AXG53_RS17490	COG2937	Belongs to the GPAT DAPAT family
AXG53_RS17500	COG0284	orotidine-5'-phosphate decarboxylase activity
AXG53_RS17505	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AXG53_RS17520	COG0210	DNA helicase
AXG53_RS17530	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AXG53_RS17535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AXG53_RS17575	COG4771	TonB-dependent receptor
AXG53_RS17590	COG1752	Esterase of the alpha-beta hydrolase superfamily
AXG53_RS17600	COG3186	Phenylalanine-4-hydroxylase
AXG53_RS17610	COG4585	Histidine kinase
AXG53_RS17615	COG2197	response regulator
AXG53_RS17670	COG1741	Belongs to the pirin family
AXG53_RS17675	COG0583	DNA-binding transcription factor activity
AXG53_RS17685	COG2755	lipolytic protein G-D-S-L family
AXG53_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS17700	COG1609	Transcriptional regulator
AXG53_RS17705	COG3507	Belongs to the glycosyl hydrolase 43 family
AXG53_RS17720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AXG53_RS17735	COG2272	Belongs to the type-B carboxylesterase lipase family
AXG53_RS17760	COG4771	TonB-dependent receptor
AXG53_RS17765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXG53_RS17770	COG0800	Aldolase
AXG53_RS17775	COG3284	Transcriptional regulator
AXG53_RS17780	COG1012	belongs to the aldehyde dehydrogenase family
AXG53_RS17795	COG4772	TonB-dependent receptor
AXG53_RS17810	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AXG53_RS17835	COG1566	PFAM secretion protein HlyD family protein
AXG53_RS17845	COG1289	transmembrane transporter activity
AXG53_RS17855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXG53_RS17895	COG0501	Belongs to the peptidase M48B family
AXG53_RS17905	COG0187	DNA topoisomerase II activity
AXG53_RS17910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXG53_RS17915	COG0592	DNA-directed DNA polymerase activity
AXG53_RS17920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AXG53_RS17925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AXG53_RS17950	COG0488	(ABC) transporter
AXG53_RS17955	COG0584	glycerophosphoryl diester phosphodiesterase
AXG53_RS17965	COG0861	Integral membrane protein TerC family
AXG53_RS17970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AXG53_RS17980	COG0531	amino acid
AXG53_RS17995	COG1322	Protein conserved in bacteria
AXG53_RS18000	COG0386	Belongs to the glutathione peroxidase family
AXG53_RS18005	COG2853	Lipoprotein
AXG53_RS18020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AXG53_RS18025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AXG53_RS18030	COG1127	ABC transporter
AXG53_RS18050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AXG53_RS18055	COG1074	ATP-dependent DNA helicase activity
AXG53_RS18060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXG53_RS18070	COG4993	Dehydrogenase
AXG53_RS18075	COG0302	gtp cyclohydrolase
AXG53_RS18095	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AXG53_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS18110	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AXG53_RS18125	COG2951	lytic endotransglycosylase activity
AXG53_RS18135	COG3135	benzoate transporter
AXG53_RS18225	COG1803	Methylglyoxal synthase
AXG53_RS18235	COG0493	'glutamate synthase
AXG53_RS18240	COG0067	glutamate synthase
AXG53_RS18240	COG0069	glutamate synthase activity
AXG53_RS18240	COG0070	glutamate synthase
AXG53_RS18260	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS18285	COG1111	helicase
AXG53_RS18285	COG1205	dead DEAH box helicase
AXG53_RS18290	COG1505	serine-type exopeptidase activity
AXG53_RS18305	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AXG53_RS18320	COG0628	permease
AXG53_RS18325	COG2031	fatty acid transporter
AXG53_RS18330	COG1335	isochorismatase
AXG53_RS18340	COG0583	DNA-binding transcription factor activity
AXG53_RS18385	COG0714	Associated with various cellular activities
AXG53_RS18405	COG0583	DNA-binding transcription factor activity
AXG53_RS18440	COG0583	DNA-binding transcription factor activity
AXG53_RS18445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXG53_RS18450	COG0798	PFAM Bile acid sodium symporter
AXG53_RS18460	COG0431	NADPH-dependent FMN reductase
AXG53_RS18490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXG53_RS18510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXG53_RS18520	COG2199	diguanylate cyclase activity
AXG53_RS18520	COG2200	EAL domain
AXG53_RS18520	COG2202	Pas domain
AXG53_RS18555	COG0174	glutamine synthetase
AXG53_RS18560	COG0347	Belongs to the P(II) protein family
AXG53_RS18565	COG0004	ammonium transporteR
AXG53_RS18580	COG3852	Histidine kinase
AXG53_RS18585	COG2204	response regulator
AXG53_RS18595	COG2032	superoxide dismutase activity
AXG53_RS18600	COG2032	superoxide dismutase activity
AXG53_RS18610	COG0183	Belongs to the thiolase family
AXG53_RS18655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXG53_RS18660	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AXG53_RS18665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXG53_RS18690	COG2823	Periplasmic or secreted lipoprotein
AXG53_RS18705	COG0066	3-isopropylmalate dehydratase activity
AXG53_RS18710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AXG53_RS18715	COG2188	Transcriptional regulator
AXG53_RS18720	COG2271	Major facilitator Superfamily
AXG53_RS18735	COG2267	carboxylic ester hydrolase activity
AXG53_RS18745	COG2188	Transcriptional regulator
AXG53_RS18765	COG1012	belongs to the aldehyde dehydrogenase family
AXG53_RS18775	COG0277	FAD linked oxidase domain protein
AXG53_RS18805	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS18810	COG3474	cytochrome
AXG53_RS18835	COG1335	isochorismatase
AXG53_RS18850	COG1028	Short-chain dehydrogenase reductase Sdr
AXG53_RS18870	COG1960	acyl-CoA dehydrogenase activity
AXG53_RS18880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXG53_RS18895	COG1643	Atp-dependent helicase
AXG53_RS18900	COG1643	Atp-dependent helicase
AXG53_RS18905	COG0084	hydrolase, TatD family'
AXG53_RS18910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AXG53_RS18915	COG0842	Transport permease protein
AXG53_RS18920	COG1131	(ABC) transporter
AXG53_RS18925	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AXG53_RS18945	COG4555	ABC transporter
AXG53_RS18965	COG0625	glutathione transferase activity
AXG53_RS18985	COG2239	Acts as a magnesium transporter
AXG53_RS18990	COG0045	succinate-CoA ligase (ADP-forming) activity
AXG53_RS18990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AXG53_RS18990	COG1042	CoA-binding domain protein
AXG53_RS19000	COG0656	L-ascorbic acid biosynthetic process
AXG53_RS19005	COG2814	Major facilitator Superfamily
AXG53_RS19010	COG0583	DNA-binding transcription factor activity
AXG53_RS19020	COG0667	Aldo Keto reductase
AXG53_RS19030	COG1187	pseudouridine synthase activity
AXG53_RS19080	COG0129	dihydroxy-acid dehydratase activity
AXG53_RS19090	COG0754	glutathionylspermidine amidase activity
AXG53_RS19100	COG0714	Associated with various cellular activities
AXG53_RS19130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AXG53_RS19145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXG53_RS19170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AXG53_RS19175	COG1040	competence protein
AXG53_RS19185	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AXG53_RS19195	COG0582	viral genome integration into host DNA
AXG53_RS19240	COG0484	heat shock protein binding
AXG53_RS19270	COG4983	Phage plasmid primase, P4 family domain protein
AXG53_RS19325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid