locus-tag	class	description
BIZ42_RS00010	COG1063	alcohol dehydrogenase
BIZ42_RS00035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ42_RS00040	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ42_RS00055	COG0010	Belongs to the arginase family
BIZ42_RS00110	COG2132	Multicopper oxidase
BIZ42_RS00135	COG0653	protein targeting
BIZ42_RS00180	COG0431	NADPH-dependent FMN reductase
BIZ42_RS00185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BIZ42_RS00255	COG0653	protein targeting
BIZ42_RS00275	COG1012	belongs to the aldehyde dehydrogenase family
BIZ42_RS00280	COG2133	pyrroloquinoline quinone binding
BIZ42_RS00305	COG1012	belongs to the aldehyde dehydrogenase family
BIZ42_RS00315	COG2814	Major facilitator Superfamily
BIZ42_RS00320	COG0583	DNA-binding transcription factor activity
BIZ42_RS00335	COG4948	Mandelate Racemase Muconate Lactonizing
BIZ42_RS00345	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
BIZ42_RS00360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ42_RS00425	COG3300	MHYT domain
BIZ42_RS00425	COG5001	Diguanylate cyclase
BIZ42_RS00455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ42_RS00460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ42_RS00465	COG0596	Alpha beta hydrolase
BIZ42_RS00475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIZ42_RS00480	COG2223	nitrite transmembrane transporter activity
BIZ42_RS00505	COG3685	Protein conserved in bacteria
BIZ42_RS00525	COG3537	Alpha-1,2-mannosidase
BIZ42_RS00535	COG0477	Major facilitator Superfamily
BIZ42_RS00540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ42_RS00575	COG2885	chlorophyll binding
BIZ42_RS00590	COG3052	prosthetic group binding
BIZ42_RS00625	COG1802	Transcriptional regulator
BIZ42_RS00635	COG5002	protein histidine kinase activity
BIZ42_RS00635	COG2198	Histidine kinase
BIZ42_RS00635	COG0784	Response regulator, receiver
BIZ42_RS00665	COG2197	response regulator
BIZ42_RS00670	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS00675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BIZ42_RS00675	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BIZ42_RS00685	COG3433	isochorismatase activity
BIZ42_RS00685	COG1535	isochorismatase
BIZ42_RS00695	COG1169	isochorismate synthase
BIZ42_RS00705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ42_RS00710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ42_RS00725	COG2409	Drug exporters of the RND superfamily
BIZ42_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS00735	COG0583	DNA-binding transcription factor activity
BIZ42_RS00750	COG1640	4-alpha-glucanotransferase
BIZ42_RS00755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BIZ42_RS00775	COG1349	DNA-binding transcription factor activity
BIZ42_RS00780	COG2223	nitrite transmembrane transporter activity
BIZ42_RS00785	COG4772	TonB-dependent receptor
BIZ42_RS00840	COG1914	H( )-stimulated, divalent metal cation uptake system
BIZ42_RS00845	COG2890	protein-(glutamine-N5) methyltransferase activity
BIZ42_RS00850	COG1999	signal sequence binding
BIZ42_RS00865	COG1845	cytochrome c oxidase, subunit III
BIZ42_RS00870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BIZ42_RS00875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BIZ42_RS00880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIZ42_RS00890	COG1309	transcriptional regulator
BIZ42_RS00910	COG0789	Transcriptional regulator
BIZ42_RS00930	COG1201	RNA secondary structure unwinding
BIZ42_RS00940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BIZ42_RS00980	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIZ42_RS01015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BIZ42_RS01020	COG3119	arylsulfatase activity
BIZ42_RS01040	COG2197	response regulator
BIZ42_RS01045	COG2197	response regulator
BIZ42_RS01065	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BIZ42_RS01105	COG4964	Belongs to the GSP D family
BIZ42_RS01165	COG4771	TonB-dependent receptor
BIZ42_RS01175	COG2134	cdp-diacylglycerol pyrophosphatase
BIZ42_RS01200	COG0277	FAD linked oxidase domain protein
BIZ42_RS01205	COG1304	FMN binding
BIZ42_RS01210	COG2186	Transcriptional regulator
BIZ42_RS01225	COG1285	pathogenesis
BIZ42_RS01240	COG1902	pentaerythritol trinitrate reductase activity
BIZ42_RS01265	COG0583	DNA-binding transcription factor activity
BIZ42_RS01270	COG1472	Belongs to the glycosyl hydrolase 3 family
BIZ42_RS01280	COG2814	Major facilitator Superfamily
BIZ42_RS01300	COG0587	DNA-directed DNA polymerase activity
BIZ42_RS01315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BIZ42_RS01325	COG2207	Transcriptional regulator
BIZ42_RS01335	COG0604	alcohol dehydrogenase
BIZ42_RS01395	COG4771	TonB-dependent receptor
BIZ42_RS01420	COG0251	oxidation-reduction process
BIZ42_RS01435	COG3275	phosphorelay sensor kinase activity
BIZ42_RS01440	COG3279	Response regulator of the LytR AlgR family
BIZ42_RS01465	COG0531	amino acid
BIZ42_RS01480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ42_RS01565	COG3447	MASE1 domain protein
BIZ42_RS01565	COG5002	protein histidine kinase activity
BIZ42_RS01565	COG5001	Diguanylate cyclase
BIZ42_RS01570	COG2183	response to ionizing radiation
BIZ42_RS01600	COG3243	poly(R)-hydroxyalkanoic acid synthase
BIZ42_RS01620	COG1051	belongs to the nudix hydrolase family
BIZ42_RS01630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BIZ42_RS01645	COG1902	pentaerythritol trinitrate reductase activity
BIZ42_RS01655	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BIZ42_RS01685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ42_RS01685	COG2205	protein histidine kinase activity
BIZ42_RS01695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BIZ42_RS01705	COG0784	Response regulator, receiver
BIZ42_RS01705	COG4191	Histidine kinase
BIZ42_RS01715	COG3300	MHYT domain
BIZ42_RS01715	COG5001	Diguanylate cyclase
BIZ42_RS01735	COG2814	Major facilitator Superfamily
BIZ42_RS01740	COG0210	DNA helicase
BIZ42_RS01750	COG4191	Histidine kinase
BIZ42_RS01750	COG0784	Response regulator, receiver
BIZ42_RS01755	COG2205	protein histidine kinase activity
BIZ42_RS01765	COG2172	sigma factor antagonist activity
BIZ42_RS01770	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ42_RS01775	COG1366	Belongs to the anti-sigma-factor antagonist family
BIZ42_RS01795	COG2353	YceI-like domain
BIZ42_RS01805	COG1858	cytochrome C peroxidase
BIZ42_RS01810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ42_RS01825	COG4251	negative regulation of phosphorylation
BIZ42_RS01830	COG0784	Response regulator, receiver
BIZ42_RS01840	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS01855	COG2135	peptidase activity
BIZ42_RS01865	COG0492	ferredoxin-NADP+ reductase activity
BIZ42_RS01885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIZ42_RS01915	COG0604	alcohol dehydrogenase
BIZ42_RS01920	COG4774	siderophore transport
BIZ42_RS02015	COG3621	Patatin-like phospholipase
BIZ42_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS02095	COG3387	PFAM Glycoside hydrolase 15-related
BIZ42_RS02110	COG3685	Protein conserved in bacteria
BIZ42_RS02120	COG1335	isochorismatase
BIZ42_RS02125	COG3546	catalase activity
BIZ42_RS02155	COG3685	Protein conserved in bacteria
BIZ42_RS02165	COG0784	Response regulator, receiver
BIZ42_RS02165	COG4191	Histidine kinase
BIZ42_RS02170	COG2204	response regulator
BIZ42_RS02230	COG2207	Transcriptional regulator
BIZ42_RS02235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BIZ42_RS02240	COG1335	isochorismatase
BIZ42_RS02255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIZ42_RS02270	COG1902	pentaerythritol trinitrate reductase activity
BIZ42_RS02280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIZ42_RS02305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIZ42_RS02335	COG0583	DNA-binding transcription factor activity
BIZ42_RS02340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BIZ42_RS02355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BIZ42_RS02370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BIZ42_RS02375	COG0077	Prephenate dehydratase
BIZ42_RS02375	COG1605	Chorismate mutase
BIZ42_RS02380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BIZ42_RS02415	COG1228	amidohydrolase
BIZ42_RS02430	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BIZ42_RS02465	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIZ42_RS02495	COG4993	Dehydrogenase
BIZ42_RS02505	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BIZ42_RS02515	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BIZ42_RS02525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BIZ42_RS02530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BIZ42_RS02550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BIZ42_RS02555	COG0360	Binds together with S18 to 16S ribosomal RNA
BIZ42_RS02560	COG0316	Belongs to the HesB IscA family
BIZ42_RS02565	COG0017	Asparaginyl-tRNA synthetase
BIZ42_RS02585	COG0288	reversible hydration of carbon dioxide
BIZ42_RS02595	COG3844	kynureninase activity
BIZ42_RS02600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BIZ42_RS02605	COG2925	Exonuclease
BIZ42_RS02630	COG2902	Dehydrogenase
BIZ42_RS02645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ42_RS02655	COG1960	acyl-CoA dehydrogenase activity
BIZ42_RS02660	COG2226	methyltransferase
BIZ42_RS02670	COG1410	methionine synthase
BIZ42_RS02670	COG0646	methionine synthase
BIZ42_RS02680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BIZ42_RS02685	COG2755	lipolytic protein G-D-S-L family
BIZ42_RS02685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BIZ42_RS02695	COG2900	Belongs to the SlyX family
BIZ42_RS02710	COG0386	Belongs to the glutathione peroxidase family
BIZ42_RS02720	COG1725	Transcriptional regulator
BIZ42_RS02725	COG1131	(ABC) transporter
BIZ42_RS02755	COG1253	flavin adenine dinucleotide binding
BIZ42_RS02765	COG2850	peptidyl-arginine hydroxylation
BIZ42_RS02775	COG0567	Dehydrogenase, E1 component
BIZ42_RS02800	COG0305	Participates in initiation and elongation during chromosome replication
BIZ42_RS02810	COG0367	asparagine synthase
BIZ42_RS02835	COG0084	hydrolase, TatD family'
BIZ42_RS02840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BIZ42_RS02870	COG1393	Belongs to the ArsC family
BIZ42_RS02895	COG1595	DNA-templated transcription, initiation
BIZ42_RS02900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BIZ42_RS02915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ42_RS02920	COG0386	Belongs to the glutathione peroxidase family
BIZ42_RS02925	COG0339	signal peptide processing
BIZ42_RS02930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BIZ42_RS02955	COG3104	oligopeptide transport
BIZ42_RS02965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIZ42_RS02985	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BIZ42_RS02985	COG0316	Belongs to the HesB IscA family
BIZ42_RS02990	COG2154	pterin-4-alpha-carbinolamine dehydratase
BIZ42_RS03000	COG0428	transporter
BIZ42_RS03005	COG0564	pseudouridine synthase activity
BIZ42_RS03010	COG1530	ribonuclease E activity
BIZ42_RS03025	COG0395	ABC-type sugar transport system, permease component
BIZ42_RS03050	COG1609	Transcriptional regulator
BIZ42_RS03060	COG2350	Protein conserved in bacteria
BIZ42_RS03065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BIZ42_RS03070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BIZ42_RS03075	COG1187	pseudouridine synthase activity
BIZ42_RS03090	COG0436	Aminotransferase
BIZ42_RS03115	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BIZ42_RS03120	COG1138	Cytochrome C-type biogenesis protein
BIZ42_RS03125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ42_RS03135	COG4235	cytochrome complex assembly
BIZ42_RS03140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BIZ42_RS03145	COG1278	Cold shock
BIZ42_RS03155	COG4988	ABC transporter
BIZ42_RS03165	COG1294	oxidase, subunit
BIZ42_RS03210	COG3210	domain, Protein
BIZ42_RS03215	COG2831	hemolysin activation secretion protein
BIZ42_RS03220	COG2807	transmembrane transport
BIZ42_RS03230	COG1649	PFAM Uncharacterised BCR, COG1649
BIZ42_RS03230	COG0726	polysaccharide deacetylase
BIZ42_RS03235	COG1215	transferase activity, transferring glycosyl groups
BIZ42_RS03260	COG0165	Argininosuccinate lyase
BIZ42_RS03265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BIZ42_RS03275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BIZ42_RS03280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIZ42_RS03285	COG0137	argininosuccinate synthase activity
BIZ42_RS03290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BIZ42_RS03305	COG2166	iron-sulfur cluster assembly
BIZ42_RS03325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIZ42_RS03345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BIZ42_RS03350	COG0402	S-adenosylhomocysteine deaminase activity
BIZ42_RS03360	COG1509	lysine 2,3-aminomutase activity
BIZ42_RS03365	COG5001	Diguanylate cyclase
BIZ42_RS03365	COG3300	MHYT domain
BIZ42_RS03380	COG0483	inositol monophosphate 1-phosphatase activity
BIZ42_RS03385	COG0501	Belongs to the peptidase M48B family
BIZ42_RS03395	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS03420	COG0860	N-Acetylmuramoyl-L-alanine amidase
BIZ42_RS03425	COG0802	atpase or kinase
BIZ42_RS03430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BIZ42_RS03430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BIZ42_RS03435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BIZ42_RS03450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BIZ42_RS03460	COG4771	TonB-dependent receptor
BIZ42_RS03475	COG2130	NADP-dependent
BIZ42_RS03490	COG0477	Major facilitator Superfamily
BIZ42_RS03515	COG1960	acyl-CoA dehydrogenase activity
BIZ42_RS03525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BIZ42_RS03555	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS03560	COG3713	MltA-interacting MipA family protein
BIZ42_RS03580	COG5487	UPF0391 membrane protein
BIZ42_RS03585	COG0454	-acetyltransferase
BIZ42_RS03590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BIZ42_RS03625	COG0776	regulation of translation
BIZ42_RS03635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BIZ42_RS03650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BIZ42_RS03655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BIZ42_RS03695	COG1185	polyribonucleotide nucleotidyltransferase activity
BIZ42_RS03700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BIZ42_RS03705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BIZ42_RS03710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BIZ42_RS03715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BIZ42_RS03720	COG0195	Participates in both transcription termination and antitermination
BIZ42_RS03725	COG0779	Required for maturation of 30S ribosomal subunits
BIZ42_RS03740	COG1007	ATP synthesis coupled electron transport
BIZ42_RS03770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BIZ42_RS03780	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BIZ42_RS03785	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BIZ42_RS03790	COG0649	NAD binding
BIZ42_RS03795	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BIZ42_RS03800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BIZ42_RS03805	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BIZ42_RS03820	COG0149	triose-phosphate isomerase activity
BIZ42_RS03830	COG0297	glycogen (starch) synthase activity
BIZ42_RS03835	COG0726	polysaccharide deacetylase
BIZ42_RS03840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIZ42_RS03845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BIZ42_RS03850	COG0159	tryptophan synthase activity
BIZ42_RS03860	COG0133	tryptophan synthase activity
BIZ42_RS03870	COG0135	phosphoribosylanthranilate isomerase activity
BIZ42_RS03875	COG0101	tRNA pseudouridine synthase activity
BIZ42_RS03885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BIZ42_RS03890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ42_RS03900	COG2890	protein-(glutamine-N5) methyltransferase activity
BIZ42_RS03905	COG1999	signal sequence binding
BIZ42_RS03910	COG0688	phosphatidylethanolamine metabolic process
BIZ42_RS03925	COG0433	COG0433 Predicted ATPase
BIZ42_RS03930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIZ42_RS03940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIZ42_RS03945	COG0412	Dienelactone hydrolase
BIZ42_RS03955	COG0717	Belongs to the dCTP deaminase family
BIZ42_RS03965	COG0489	protein tyrosine kinase activity
BIZ42_RS03970	COG4771	TonB-dependent receptor
BIZ42_RS03975	COG4771	TonB-dependent receptor
BIZ42_RS03980	COG4771	TonB-dependent receptor
BIZ42_RS03985	COG3590	peptidase
BIZ42_RS04015	COG2311	Membrane
BIZ42_RS04025	COG0791	NLP P60 protein
BIZ42_RS04030	COG0791	NLP P60 protein
BIZ42_RS04070	COG1301	dicarboxylic acid transport
BIZ42_RS04090	COG1722	exodeoxyribonuclease VII activity
BIZ42_RS04095	COG0142	geranyltranstransferase activity
BIZ42_RS04105	COG0312	modulator of DNA gyrase
BIZ42_RS04110	COG3028	Belongs to the UPF0307 family
BIZ42_RS04115	COG0312	modulator of DNA gyrase
BIZ42_RS04135	COG2968	Membrane
BIZ42_RS04140	COG4771	TonB-dependent receptor
BIZ42_RS04150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BIZ42_RS04160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BIZ42_RS04175	COG0495	leucyl-tRNA aminoacylation
BIZ42_RS04195	COG4251	negative regulation of phosphorylation
BIZ42_RS04195	COG2203	Gaf domain
BIZ42_RS04195	COG5001	Diguanylate cyclase
BIZ42_RS04195	COG3706	GGDEF domain
BIZ42_RS04230	COG0346	lactoylglutathione lyase activity
BIZ42_RS04240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ42_RS04240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BIZ42_RS04250	COG2878	Part of a membrane complex involved in electron transport
BIZ42_RS04255	COG0251	oxidation-reduction process
BIZ42_RS04260	COG0392	lysyltransferase activity
BIZ42_RS04260	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BIZ42_RS04290	COG2824	Alkylphosphonate utilization operon protein PhnA
BIZ42_RS04335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BIZ42_RS04345	COG1451	nucleotide metabolic process
BIZ42_RS04355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIZ42_RS04375	COG0183	Belongs to the thiolase family
BIZ42_RS04390	COG1960	acyl-CoA dehydrogenase activity
BIZ42_RS04400	COG1793	dna ligase
BIZ42_RS04405	COG1201	RNA secondary structure unwinding
BIZ42_RS04420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BIZ42_RS04425	COG1278	Cold shock
BIZ42_RS04430	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BIZ42_RS04435	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BIZ42_RS04440	COG1472	Belongs to the glycosyl hydrolase 3 family
BIZ42_RS04445	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BIZ42_RS04450	COG2954	triphosphatase activity
BIZ42_RS04460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BIZ42_RS04465	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS04475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BIZ42_RS04490	COG0681	Belongs to the peptidase S26 family
BIZ42_RS04495	COG0481	GTPase activity
BIZ42_RS04500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIZ42_RS04515	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ42_RS04515	COG1024	Enoyl-CoA hydratase
BIZ42_RS04520	COG1741	Belongs to the pirin family
BIZ42_RS04525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BIZ42_RS04535	COG1741	Belongs to the pirin family
BIZ42_RS04540	COG1966	Carbon starvation protein
BIZ42_RS04545	COG2879	small protein
BIZ42_RS04550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BIZ42_RS04560	COG2972	Histidine kinase
BIZ42_RS04565	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS04580	COG2194	sulfuric ester hydrolase activity
BIZ42_RS04600	COG2814	Major facilitator Superfamily
BIZ42_RS04605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIZ42_RS04605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BIZ42_RS04610	COG1113	amino acid transport
BIZ42_RS04615	COG1917	Cupin 2, conserved barrel domain protein
BIZ42_RS04615	COG2207	Transcriptional regulator
BIZ42_RS04620	COG0753	catalase activity
BIZ42_RS04630	COG2205	protein histidine kinase activity
BIZ42_RS04635	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS04650	COG0840	transmembrane signaling receptor activity
BIZ42_RS04655	COG1376	ErfK ybiS ycfS ynhG family protein
BIZ42_RS04660	COG0739	heme binding
BIZ42_RS04675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BIZ42_RS04685	COG0330	HflC and HflK could
BIZ42_RS04690	COG0330	HflC and HflK could
BIZ42_RS04695	COG0604	alcohol dehydrogenase
BIZ42_RS04710	COG0678	peroxiredoxin activity
BIZ42_RS04720	COG4953	penicillin-binding protein 1C
BIZ42_RS04725	COG2373	Large extracellular alpha-helical protein
BIZ42_RS04730	COG2079	MmgE PrpD family protein
BIZ42_RS04735	COG2828	Protein conserved in bacteria
BIZ42_RS04745	COG3609	addiction module antidote protein, CC2985 family
BIZ42_RS04750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BIZ42_RS04765	COG3829	transcription factor binding
BIZ42_RS04790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BIZ42_RS04810	COG2814	Major facilitator Superfamily
BIZ42_RS04825	COG0784	Response regulator, receiver
BIZ42_RS04825	COG5002	protein histidine kinase activity
BIZ42_RS04830	COG2198	Histidine kinase
BIZ42_RS04830	COG2205	protein histidine kinase activity
BIZ42_RS04830	COG0784	Response regulator, receiver
BIZ42_RS04835	COG2353	YceI-like domain
BIZ42_RS04840	COG3038	cytochrome b561
BIZ42_RS04845	COG2353	YceI-like domain
BIZ42_RS04855	COG1760	l-serine dehydratase
BIZ42_RS04860	COG2267	carboxylic ester hydrolase activity
BIZ42_RS04865	COG0527	aspartate kinase activity
BIZ42_RS04865	COG0460	homoserine dehydrogenase
BIZ42_RS04870	COG0626	cystathionine gamma-synthase activity
BIZ42_RS04875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BIZ42_RS04880	COG0739	heme binding
BIZ42_RS04885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BIZ42_RS04890	COG1272	protein, Hemolysin III
BIZ42_RS04895	COG2982	Protein involved in outer membrane biogenesis
BIZ42_RS04905	COG0463	Glycosyl transferase, family 2
BIZ42_RS04910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIZ42_RS04915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BIZ42_RS04925	COG4206	TonB-dependent receptor
BIZ42_RS04930	COG1309	transcriptional regulator
BIZ42_RS04940	COG1960	acyl-CoA dehydrogenase activity
BIZ42_RS04980	COG0509	glycine decarboxylation via glycine cleavage system
BIZ42_RS04985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BIZ42_RS04995	COG0330	HflC and HflK could
BIZ42_RS05005	COG3956	TIGRFAM MazG family protein
BIZ42_RS05010	COG1218	3'(2'),5'-bisphosphate nucleotidase
BIZ42_RS05015	COG0494	nUDIX hydrolase
BIZ42_RS05025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BIZ42_RS05045	COG0840	transmembrane signaling receptor activity
BIZ42_RS05050	COG0835	chemotaxis
BIZ42_RS05065	COG0189	ligase activity
BIZ42_RS05075	COG1214	PFAM Peptidase M22, glycoprotease
BIZ42_RS05080	COG1199	ATP-dependent helicase activity
BIZ42_RS05090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BIZ42_RS05095	COG1216	Glycosyl transferase, family 2
BIZ42_RS05105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIZ42_RS05115	COG1643	Atp-dependent helicase
BIZ42_RS05120	COG0783	Belongs to the Dps family
BIZ42_RS05125	COG0514	ATP-dependent DNA helicase (RecQ)
BIZ42_RS05135	COG2132	Multicopper oxidase
BIZ42_RS05205	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BIZ42_RS05210	COG0602	queuosine metabolic process
BIZ42_RS05220	COG2885	chlorophyll binding
BIZ42_RS05245	COG0824	Thioesterase
BIZ42_RS05250	COG2255	four-way junction helicase activity
BIZ42_RS05260	COG0632	four-way junction helicase activity
BIZ42_RS05265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BIZ42_RS05270	COG0217	transcriptional regulatory protein
BIZ42_RS05285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BIZ42_RS05320	COG0488	(ABC) transporter
BIZ42_RS05330	COG4651	solute:proton antiporter activity
BIZ42_RS05330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BIZ42_RS05345	COG0542	response to heat
BIZ42_RS05365	COG0028	Belongs to the TPP enzyme family
BIZ42_RS05390	COG3387	PFAM Glycoside hydrolase 15-related
BIZ42_RS05395	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BIZ42_RS05405	COG0564	pseudouridine synthase activity
BIZ42_RS05410	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BIZ42_RS05420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BIZ42_RS05420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BIZ42_RS05430	COG0045	succinate-CoA ligase (ADP-forming) activity
BIZ42_RS05445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIZ42_RS05460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BIZ42_RS05465	COG0237	dephospho-CoA kinase activity
BIZ42_RS05475	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS05485	COG0189	ligase activity
BIZ42_RS05490	COG4319	ketosteroid isomerase
BIZ42_RS05505	COG2104	thiamine diphosphate biosynthetic process
BIZ42_RS05510	COG2022	thiamine diphosphate biosynthetic process
BIZ42_RS05515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BIZ42_RS05520	COG0471	metal ion transport
BIZ42_RS05520	COG3273	potassium ion transport
BIZ42_RS05535	COG0179	Fumarylacetoacetate (FAA) hydrolase
BIZ42_RS05540	COG1970	mechanosensitive ion channel activity
BIZ42_RS05550	COG1115	amino acid carrier protein
BIZ42_RS05560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIZ42_RS05565	COG1115	amino acid carrier protein
BIZ42_RS05570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ42_RS05575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ42_RS05600	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BIZ42_RS05610	COG3588	fructose-bisphosphate aldolase
BIZ42_RS05615	COG0469	pyruvate kinase activity
BIZ42_RS05625	COG0126	phosphoglycerate kinase activity
BIZ42_RS05640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BIZ42_RS05645	COG3047	cAMP biosynthetic process
BIZ42_RS05650	COG1794	racemase activity, acting on amino acids and derivatives
BIZ42_RS05660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ42_RS05660	COG3453	Protein conserved in bacteria
BIZ42_RS05680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BIZ42_RS05690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BIZ42_RS05695	COG1301	dicarboxylic acid transport
BIZ42_RS05705	COG2304	oxidoreductase activity
BIZ42_RS05710	COG2304	oxidoreductase activity
BIZ42_RS05725	COG0714	Associated with various cellular activities
BIZ42_RS05755	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BIZ42_RS05765	COG0596	Alpha beta hydrolase
BIZ42_RS05785	COG0254	rRNA binding
BIZ42_RS05790	COG1957	nucleoside hydrolase
BIZ42_RS05795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BIZ42_RS05805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BIZ42_RS05810	COG1758	RNA polymerase activity
BIZ42_RS05820	COG1561	YicC-like family, N-terminal region
BIZ42_RS05825	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BIZ42_RS05830	COG0346	lactoylglutathione lyase activity
BIZ42_RS05840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BIZ42_RS05855	COG0006	proline dipeptidase activity
BIZ42_RS05860	COG0006	proline dipeptidase activity
BIZ42_RS05865	COG3079	Belongs to the UPF0149 family
BIZ42_RS05885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BIZ42_RS05895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BIZ42_RS05905	COG2912	Transglutaminase-like superfamily
BIZ42_RS05910	COG1773	rubredoxin
BIZ42_RS05915	COG0352	thiamine-phosphate diphosphorylase activity
BIZ42_RS05920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIZ42_RS05925	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BIZ42_RS05935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BIZ42_RS05940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ42_RS05965	COG0671	phosphoesterase, PA-phosphatase related
BIZ42_RS05975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BIZ42_RS05980	COG0563	adenylate kinase activity
BIZ42_RS05995	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BIZ42_RS06010	COG0848	biopolymer transport protein
BIZ42_RS06020	COG2832	Protein of unknown function (DUF454)
BIZ42_RS06060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BIZ42_RS06075	COG4771	TonB-dependent receptor
BIZ42_RS06095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BIZ42_RS06105	COG0405	Gamma-glutamyltransferase
BIZ42_RS06110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BIZ42_RS06130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BIZ42_RS06135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BIZ42_RS06145	COG0473	3-isopropylmalate dehydrogenase activity
BIZ42_RS06150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BIZ42_RS06160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ42_RS06175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BIZ42_RS06180	COG1538	Outer membrane efflux protein
BIZ42_RS06190	COG2239	Acts as a magnesium transporter
BIZ42_RS06195	COG1519	Transferase
BIZ42_RS06200	COG1560	Kdo2-lipid A biosynthetic process
BIZ42_RS06235	COG1301	dicarboxylic acid transport
BIZ42_RS06245	COG4191	Histidine kinase
BIZ42_RS06255	COG2851	Citrate transporter
BIZ42_RS06265	COG0642	Histidine kinase
BIZ42_RS06280	COG2851	Citrate transporter
BIZ42_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS06310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIZ42_RS06315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIZ42_RS06365	COG3829	transcription factor binding
BIZ42_RS06425	COG1162	GTPase activity
BIZ42_RS06430	COG0436	Aminotransferase
BIZ42_RS06460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BIZ42_RS06480	COG3964	amidohydrolase
BIZ42_RS06485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BIZ42_RS06495	COG1307	EDD domain protein, DegV family
BIZ42_RS06535	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BIZ42_RS06550	COG0583	DNA-binding transcription factor activity
BIZ42_RS06555	COG1064	alcohol dehydrogenase
BIZ42_RS06580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BIZ42_RS06605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BIZ42_RS06615	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BIZ42_RS06620	COG5006	permease, DMT superfamily
BIZ42_RS06625	COG1522	sequence-specific DNA binding
BIZ42_RS06645	COG4773	Receptor
BIZ42_RS06650	COG1280	lysine exporter protein (LysE YggA)
BIZ42_RS06655	COG4206	TonB-dependent receptor
BIZ42_RS06670	COG0617	tRNA 3'-terminal CCA addition
BIZ42_RS06690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BIZ42_RS06695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIZ42_RS06700	COG1609	Transcriptional regulator
BIZ42_RS06710	COG0837	glucose binding
BIZ42_RS06720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BIZ42_RS06750	COG3852	Histidine kinase
BIZ42_RS06755	COG0784	Response regulator, receiver
BIZ42_RS06760	COG4251	negative regulation of phosphorylation
BIZ42_RS06765	COG2823	Periplasmic or secreted lipoprotein
BIZ42_RS06770	COG0673	inositol 2-dehydrogenase activity
BIZ42_RS06775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BIZ42_RS06805	COG2921	Belongs to the UPF0250 family
BIZ42_RS06815	COG1686	Belongs to the peptidase S11 family
BIZ42_RS06820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BIZ42_RS06825	COG2951	lytic endotransglycosylase activity
BIZ42_RS06830	COG0772	Belongs to the SEDS family
BIZ42_RS06835	COG0772	Belongs to the SEDS family
BIZ42_RS06840	COG0768	penicillin binding
BIZ42_RS06850	COG1792	Involved in formation and maintenance of cell shape
BIZ42_RS06855	COG1077	Cell shape determining protein MreB Mrl
BIZ42_RS06860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIZ42_RS06885	COG0308	aminopeptidase N
BIZ42_RS06890	COG5001	Diguanylate cyclase
BIZ42_RS06895	COG2226	methyltransferase
BIZ42_RS06925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ42_RS06930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ42_RS06945	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BIZ42_RS06960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BIZ42_RS06975	COG0436	Aminotransferase
BIZ42_RS06980	COG1505	serine-type exopeptidase activity
BIZ42_RS07000	COG2011	ABC-type metal ion transport system permease component
BIZ42_RS07010	COG0697	spore germination
BIZ42_RS07015	COG1666	GTP binding
BIZ42_RS07045	COG0339	signal peptide processing
BIZ42_RS07050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BIZ42_RS07075	COG1573	uracil-dna glycosylase
BIZ42_RS07080	COG0517	IMP dehydrogenase activity
BIZ42_RS07085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BIZ42_RS07095	COG1136	(ABC) transporter
BIZ42_RS07105	COG0577	efflux transmembrane transporter activity
BIZ42_RS07105	COG1136	(ABC) transporter
BIZ42_RS07120	COG4191	Histidine kinase
BIZ42_RS07125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BIZ42_RS07135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BIZ42_RS07140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BIZ42_RS07150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BIZ42_RS07155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BIZ42_RS07160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BIZ42_RS07170	COG0356	it plays a direct role in the translocation of protons across the membrane
BIZ42_RS07185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BIZ42_RS07195	COG0508	dehydrogenase complex catalyzes the overall conversion of
BIZ42_RS07215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BIZ42_RS07240	COG0181	hydroxymethylbilane synthase activity
BIZ42_RS07250	COG3275	phosphorelay sensor kinase activity
BIZ42_RS07280	COG0840	transmembrane signaling receptor activity
BIZ42_RS07285	COG0659	secondary active sulfate transmembrane transporter activity
BIZ42_RS07290	COG0697	spore germination
BIZ42_RS07295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIZ42_RS07340	COG1335	isochorismatase
BIZ42_RS07370	COG0583	DNA-binding transcription factor activity
BIZ42_RS07375	COG1902	pentaerythritol trinitrate reductase activity
BIZ42_RS07380	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS07390	COG0300	oxidoreductase activity
BIZ42_RS07400	COG3550	peptidyl-serine autophosphorylation
BIZ42_RS07405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BIZ42_RS07410	COG1490	D-aminoacyl-tRNA deacylase activity
BIZ42_RS07420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BIZ42_RS07435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BIZ42_RS07450	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BIZ42_RS07455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BIZ42_RS07455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIZ42_RS07460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BIZ42_RS07465	COG0242	peptide deformylase activity
BIZ42_RS07475	COG0758	DNA mediated transformation
BIZ42_RS07480	COG2922	Belongs to the Smg family
BIZ42_RS07490	COG1714	RDD family
BIZ42_RS07495	COG1754	DNA topoisomerase type I activity
BIZ42_RS07495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BIZ42_RS07500	COG0009	L-threonylcarbamoyladenylate synthase
BIZ42_RS07525	COG0616	signal peptide processing
BIZ42_RS07530	COG0534	Mate efflux family protein
BIZ42_RS07545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BIZ42_RS07550	COG0625	glutathione transferase activity
BIZ42_RS07560	COG1252	NADH dehydrogenase
BIZ42_RS07575	COG2860	membrane
BIZ42_RS07590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ42_RS07605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BIZ42_RS07620	COG1846	Transcriptional regulator
BIZ42_RS07640	COG0625	glutathione transferase activity
BIZ42_RS07650	COG0459	protein refolding
BIZ42_RS07655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BIZ42_RS07660	COG2356	endonuclease I
BIZ42_RS07665	COG1324	tolerance protein
BIZ42_RS07680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIZ42_RS07690	COG0840	transmembrane signaling receptor activity
BIZ42_RS07740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BIZ42_RS07750	COG0511	ligase activity, forming carbon-carbon bonds
BIZ42_RS07755	COG0439	Biotin carboxylase
BIZ42_RS07770	COG2264	protein methyltransferase activity
BIZ42_RS07780	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BIZ42_RS07785	COG0138	bifunctional purine biosynthesis protein purh
BIZ42_RS07795	COG0151	Belongs to the GarS family
BIZ42_RS07835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BIZ42_RS07840	COG2201	protein-glutamate methylesterase activity
BIZ42_RS07845	COG2177	Part of the ABC transporter FtsEX involved in
BIZ42_RS07850	COG2884	Cell division ATP-binding protein ftsE
BIZ42_RS07855	COG0513	Belongs to the DEAD box helicase family
BIZ42_RS07860	COG3118	belongs to the thioredoxin family
BIZ42_RS07865	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BIZ42_RS07870	COG1472	Belongs to the glycosyl hydrolase 3 family
BIZ42_RS07875	COG1609	Transcriptional regulator
BIZ42_RS07905	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BIZ42_RS07920	COG1652	LysM domain
BIZ42_RS07925	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BIZ42_RS07925	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BIZ42_RS07930	COG1473	amidohydrolase
BIZ42_RS07940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ42_RS07955	COG1289	transmembrane transporter activity
BIZ42_RS07975	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BIZ42_RS07985	COG0316	Belongs to the HesB IscA family
BIZ42_RS08010	COG5002	protein histidine kinase activity
BIZ42_RS08010	COG2205	protein histidine kinase activity
BIZ42_RS08010	COG0784	Response regulator, receiver
BIZ42_RS08015	COG2193	ferroxidase activity
BIZ42_RS08025	COG1051	belongs to the nudix hydrolase family
BIZ42_RS08040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BIZ42_RS08045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BIZ42_RS08050	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BIZ42_RS08060	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BIZ42_RS08065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ42_RS08070	COG0730	response to heat
BIZ42_RS08080	COG0134	indole-3-glycerol-phosphate synthase activity
BIZ42_RS08085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BIZ42_RS08120	COG1597	lipid kinase activity
BIZ42_RS08135	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BIZ42_RS08140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BIZ42_RS08150	COG2111	Na H antiporter
BIZ42_RS08150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BIZ42_RS08155	COG1006	Multisubunit Na H antiporter MnhC subunit
BIZ42_RS08160	COG0651	ATP synthesis coupled electron transport
BIZ42_RS08165	COG1863	multisubunit Na H antiporter MnhE subunit
BIZ42_RS08170	COG2212	antiporter activity
BIZ42_RS08175	COG1320	monovalent cation:proton antiporter activity
BIZ42_RS08180	COG0530	calcium, potassium:sodium antiporter activity
BIZ42_RS08205	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BIZ42_RS08230	COG3104	oligopeptide transport
BIZ42_RS08235	COG3483	tryptophan 2,3-dioxygenase activity
BIZ42_RS08240	COG0702	epimerase
BIZ42_RS08260	COG2354	Protein conserved in bacteria
BIZ42_RS08265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BIZ42_RS08270	COG1368	sulfuric ester hydrolase activity
BIZ42_RS08275	COG3264	Mechanosensitive ion channel
BIZ42_RS08275	COG1196	nuclear chromosome segregation
BIZ42_RS08285	COG3040	lipid binding
BIZ42_RS08290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIZ42_RS08290	COG0723	plastoquinol--plastocyanin reductase activity
BIZ42_RS08325	COG1166	arginine decarboxylase activity
BIZ42_RS08330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BIZ42_RS08355	COG0561	phosphatase activity
BIZ42_RS08360	COG0606	chelatase, subunit chli
BIZ42_RS08370	COG0435	Glutathione S-transferase
BIZ42_RS08380	COG2031	fatty acid transporter
BIZ42_RS08395	COG0673	inositol 2-dehydrogenase activity
BIZ42_RS08410	COG2222	sugar isomerase
BIZ42_RS08415	COG1940	carbohydrate kinase activity
BIZ42_RS08425	COG1349	DNA-binding transcription factor activity
BIZ42_RS08430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BIZ42_RS08435	COG2814	Major facilitator Superfamily
BIZ42_RS08455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BIZ42_RS08465	COG2267	carboxylic ester hydrolase activity
BIZ42_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS08485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BIZ42_RS08500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BIZ42_RS08525	COG0714	Associated with various cellular activities
BIZ42_RS08540	COG0754	glutathionylspermidine amidase activity
BIZ42_RS08550	COG0129	dihydroxy-acid dehydratase activity
BIZ42_RS08560	COG1199	ATP-dependent helicase activity
BIZ42_RS08570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BIZ42_RS08590	COG3781	membrane
BIZ42_RS08620	COG0625	glutathione transferase activity
BIZ42_RS08645	COG4555	ABC transporter
BIZ42_RS08660	COG0543	2 iron, 2 sulfur cluster binding
BIZ42_RS08660	COG0633	Ferredoxin
BIZ42_RS08665	COG1131	(ABC) transporter
BIZ42_RS08670	COG0842	Transport permease protein
BIZ42_RS08675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BIZ42_RS08685	COG0084	hydrolase, TatD family'
BIZ42_RS08690	COG1643	Atp-dependent helicase
BIZ42_RS08700	COG1187	pseudouridine synthase activity
BIZ42_RS08710	COG0667	Aldo Keto reductase
BIZ42_RS08715	COG3634	alkyl hydroperoxide reductase activity
BIZ42_RS08720	COG1959	2 iron, 2 sulfur cluster binding
BIZ42_RS08725	COG0840	transmembrane signaling receptor activity
BIZ42_RS08730	COG0583	DNA-binding transcription factor activity
BIZ42_RS08735	COG2814	Major facilitator Superfamily
BIZ42_RS08740	COG0656	L-ascorbic acid biosynthetic process
BIZ42_RS08745	COG2267	carboxylic ester hydrolase activity
BIZ42_RS08755	COG0045	succinate-CoA ligase (ADP-forming) activity
BIZ42_RS08755	COG1042	CoA-binding domain protein
BIZ42_RS08755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIZ42_RS08760	COG2239	Acts as a magnesium transporter
BIZ42_RS08785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIZ42_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS08800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIZ42_RS08830	COG2986	histidine ammonia-lyase
BIZ42_RS08855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIZ42_RS08860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BIZ42_RS08875	COG0251	oxidation-reduction process
BIZ42_RS08880	COG1294	oxidase, subunit
BIZ42_RS08885	COG1271	oxidase subunit
BIZ42_RS08910	COG0408	coproporphyrinogen oxidase activity
BIZ42_RS08915	COG2323	membrane
BIZ42_RS08935	COG0589	response to stress
BIZ42_RS08970	COG0210	DNA helicase
BIZ42_RS08985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIZ42_RS08990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BIZ42_RS08995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BIZ42_RS09035	COG0463	Glycosyl transferase, family 2
BIZ42_RS09050	COG1475	DNA binding
BIZ42_RS09055	COG1192	Involved in chromosome partitioning
BIZ42_RS09060	COG0357	Ribosomal RNA small subunit methyltransferase G
BIZ42_RS09115	COG1971	Probably functions as a manganese efflux pump
BIZ42_RS09120	COG0784	Response regulator, receiver
BIZ42_RS09120	COG2205	protein histidine kinase activity
BIZ42_RS09135	COG0729	surface antigen
BIZ42_RS09145	COG0752	glycyl-tRNA synthetase alpha subunit
BIZ42_RS09150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIZ42_RS09165	COG0805	protein transport
BIZ42_RS09175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BIZ42_RS09185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BIZ42_RS09190	COG0596	Alpha beta hydrolase
BIZ42_RS09190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BIZ42_RS09195	COG0840	transmembrane signaling receptor activity
BIZ42_RS09250	COG3135	benzoate transporter
BIZ42_RS09255	COG0676	glucose-6-phosphate 1-epimerase activity
BIZ42_RS09260	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BIZ42_RS09265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BIZ42_RS09270	COG3012	SEC-C Motif Domain Protein
BIZ42_RS09295	COG0302	gtp cyclohydrolase
BIZ42_RS09310	COG1566	PFAM secretion protein HlyD family protein
BIZ42_RS09320	COG1289	transmembrane transporter activity
BIZ42_RS09330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BIZ42_RS09335	COG1074	ATP-dependent DNA helicase activity
BIZ42_RS09340	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BIZ42_RS09345	COG1127	ABC transporter
BIZ42_RS09350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BIZ42_RS09355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BIZ42_RS09370	COG2853	Lipoprotein
BIZ42_RS09375	COG0386	Belongs to the glutathione peroxidase family
BIZ42_RS09385	COG1322	Protein conserved in bacteria
BIZ42_RS09395	COG0583	DNA-binding transcription factor activity
BIZ42_RS09415	COG0667	Aldo Keto reductase
BIZ42_RS09420	COG0531	amino acid
BIZ42_RS09430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BIZ42_RS09435	COG0861	Integral membrane protein TerC family
BIZ42_RS09445	COG0584	glycerophosphoryl diester phosphodiesterase
BIZ42_RS09455	COG0706	membrane insertase activity
BIZ42_RS09460	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BIZ42_RS09465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BIZ42_RS09475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BIZ42_RS09480	COG0187	DNA topoisomerase II activity
BIZ42_RS09485	COG1266	CAAX protease self-immunity
BIZ42_RS09490	COG0501	Belongs to the peptidase M48B family
BIZ42_RS09520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIZ42_RS09590	COG5642	Protein of unknown function (DUF2384)
BIZ42_RS09625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BIZ42_RS09635	COG4772	TonB-dependent receptor
BIZ42_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
BIZ42_RS09680	COG3284	Transcriptional regulator
BIZ42_RS09685	COG0800	Aldolase
BIZ42_RS09710	COG0384	phenazine biosynthesis protein PhzF
BIZ42_RS09720	COG2755	lipolytic protein G-D-S-L family
BIZ42_RS09725	COG2272	Belongs to the type-B carboxylesterase lipase family
BIZ42_RS09740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BIZ42_RS09760	COG3507	Belongs to the glycosyl hydrolase 43 family
BIZ42_RS09765	COG1609	Transcriptional regulator
BIZ42_RS09775	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS09780	COG2755	lipolytic protein G-D-S-L family
BIZ42_RS09790	COG3186	Phenylalanine-4-hydroxylase
BIZ42_RS09795	COG1522	sequence-specific DNA binding
BIZ42_RS09800	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIZ42_RS09805	COG4771	TonB-dependent receptor
BIZ42_RS09820	COG1119	ATPase activity
BIZ42_RS09835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BIZ42_RS09845	COG0515	serine threonine protein kinase
BIZ42_RS09845	COG2815	serine threonine protein kinase
BIZ42_RS09850	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BIZ42_RS09865	COG0210	DNA helicase
BIZ42_RS09870	COG0519	Catalyzes the synthesis of GMP from XMP
BIZ42_RS09880	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BIZ42_RS09885	COG0284	orotidine-5'-phosphate decarboxylase activity
BIZ42_RS09895	COG2937	Belongs to the GPAT DAPAT family
BIZ42_RS09905	COG0037	tRNA processing
BIZ42_RS09910	COG2974	May be involved in recombination
BIZ42_RS09920	COG1803	Methylglyoxal synthase
BIZ42_RS09930	COG0493	'glutamate synthase
BIZ42_RS09935	COG0067	glutamate synthase
BIZ42_RS09935	COG0069	glutamate synthase activity
BIZ42_RS09935	COG0070	glutamate synthase
BIZ42_RS09955	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS09985	COG1205	dead DEAH box helicase
BIZ42_RS09985	COG1111	helicase
BIZ42_RS10030	COG0714	Associated with various cellular activities
BIZ42_RS10070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIZ42_RS10090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BIZ42_RS10130	COG0174	glutamine synthetase
BIZ42_RS10135	COG0347	Belongs to the P(II) protein family
BIZ42_RS10140	COG0004	ammonium transporteR
BIZ42_RS10145	COG3023	N-Acetylmuramoyl-L-alanine amidase
BIZ42_RS10165	COG3852	Histidine kinase
BIZ42_RS10170	COG2204	response regulator
BIZ42_RS10175	COG2032	superoxide dismutase activity
BIZ42_RS10180	COG2032	superoxide dismutase activity
BIZ42_RS10220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BIZ42_RS10225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BIZ42_RS10230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BIZ42_RS10240	COG2197	response regulator
BIZ42_RS10245	COG2205	protein histidine kinase activity
BIZ42_RS10245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ42_RS10250	COG3474	cytochrome
BIZ42_RS10260	COG1960	acyl-CoA dehydrogenase activity
BIZ42_RS10265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BIZ42_RS10275	COG0612	Peptidase, M16
BIZ42_RS10285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIZ42_RS10290	COG0596	Alpha beta hydrolase
BIZ42_RS10300	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ42_RS10305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BIZ42_RS10315	COG1181	Belongs to the D-alanine--D-alanine ligase family
BIZ42_RS10330	COG0564	pseudouridine synthase activity
BIZ42_RS10350	COG0339	signal peptide processing
BIZ42_RS10370	COG2814	Major facilitator Superfamily
BIZ42_RS10375	COG0583	DNA-binding transcription factor activity
BIZ42_RS10380	COG0583	DNA-binding transcription factor activity
BIZ42_RS10385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BIZ42_RS10390	COG2224	Isocitrate lyase
BIZ42_RS10420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BIZ42_RS10425	COG1960	acyl-CoA dehydrogenase activity
BIZ42_RS10445	COG0697	spore germination
BIZ42_RS10455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BIZ42_RS10470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BIZ42_RS10475	COG1607	acyl-coa hydrolase
BIZ42_RS10485	COG1902	pentaerythritol trinitrate reductase activity
BIZ42_RS10495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BIZ42_RS10505	COG1335	isochorismatase
BIZ42_RS10510	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BIZ42_RS10515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BIZ42_RS10575	COG1752	Esterase of the alpha-beta hydrolase superfamily
BIZ42_RS10580	COG1396	sequence-specific DNA binding
BIZ42_RS10580	COG3800	Transcriptional regulator
BIZ42_RS10590	COG1960	acyl-CoA dehydrogenase activity
BIZ42_RS10595	COG1024	Enoyl-CoA hydratase
BIZ42_RS10600	COG1024	Enoyl-CoA hydratase
BIZ42_RS10610	COG1764	response to oxidative stress
BIZ42_RS10625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIZ42_RS10645	COG3228	Belongs to the MtfA family
BIZ42_RS10655	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BIZ42_RS10655	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BIZ42_RS10660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BIZ42_RS10685	COG3237	CsbD-like
BIZ42_RS10695	COG0180	Tryptophanyl-tRNA synthetase
BIZ42_RS10715	COG0477	Major facilitator Superfamily
BIZ42_RS10720	COG0697	spore germination
BIZ42_RS10740	COG0577	efflux transmembrane transporter activity
BIZ42_RS10745	COG1136	(ABC) transporter
BIZ42_RS10750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ42_RS10755	COG1131	(ABC) transporter
BIZ42_RS10765	COG4585	Histidine kinase
BIZ42_RS10770	COG2197	response regulator
BIZ42_RS10775	COG3038	cytochrome b561
BIZ42_RS10780	COG0753	catalase activity
BIZ42_RS10785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BIZ42_RS10790	COG1011	Hydrolase
BIZ42_RS10800	COG0628	permease
BIZ42_RS10820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BIZ42_RS10880	COG5507	3-demethylubiquinone-9 3-methyltransferase
BIZ42_RS10895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIZ42_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS10910	COG2271	Major facilitator Superfamily
BIZ42_RS10930	COG2186	Transcriptional regulator
BIZ42_RS10945	COG2814	Major facilitator Superfamily
BIZ42_RS10950	COG4807	Protein conserved in bacteria
BIZ42_RS10960	COG4221	oxidoreductase activity
BIZ42_RS10975	COG0018	arginyl-trna synthetase
BIZ42_RS10990	COG0756	dUTP diphosphatase activity
BIZ42_RS11005	COG2205	protein histidine kinase activity
BIZ42_RS11015	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BIZ42_RS11020	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BIZ42_RS11035	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BIZ42_RS11040	COG0708	Exodeoxyribonuclease III
BIZ42_RS11045	COG2814	Major facilitator Superfamily
BIZ42_RS11060	COG0739	heme binding
BIZ42_RS11065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BIZ42_RS11110	COG4942	peptidase
BIZ42_RS11115	COG0793	Belongs to the peptidase S41A family
BIZ42_RS11150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BIZ42_RS11160	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BIZ42_RS11190	COG0109	protoheme IX farnesyltransferase activity
BIZ42_RS11210	COG0358	DNA primase activity
BIZ42_RS11215	COG1295	ribonuclease BN
BIZ42_RS11225	COG1610	YqeY-like protein
BIZ42_RS11235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BIZ42_RS11245	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BIZ42_RS11250	COG0668	transmembrane transport
BIZ42_RS11265	COG2133	pyrroloquinoline quinone binding
BIZ42_RS11275	COG0531	amino acid
BIZ42_RS11285	COG1737	Transcriptional regulator
BIZ42_RS11290	COG4948	Mandelate Racemase Muconate Lactonizing
BIZ42_RS11310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIZ42_RS11315	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BIZ42_RS11340	COG5383	Protein conserved in bacteria
BIZ42_RS11350	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BIZ42_RS11385	COG0778	Nitroreductase
BIZ42_RS11390	COG2353	YceI-like domain
BIZ42_RS11400	COG2375	cellular response to nickel ion
BIZ42_RS11420	COG2801	Transposase and inactivated derivatives
BIZ42_RS11465	COG2267	carboxylic ester hydrolase activity
BIZ42_RS11475	COG1943	Transposase
BIZ42_RS11495	COG0523	cobalamin synthesis protein
BIZ42_RS11500	COG0488	(ABC) transporter
BIZ42_RS11505	COG0583	DNA-binding transcription factor activity
BIZ42_RS11515	COG2814	Major facilitator Superfamily
BIZ42_RS11525	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BIZ42_RS11530	COG1113	amino acid transport
BIZ42_RS11550	COG3795	YCII-related domain
BIZ42_RS11555	COG2764	glyoxalase bleomycin resistance protein dioxygenase
BIZ42_RS11565	COG4941	Belongs to the sigma-70 factor family
BIZ42_RS11575	COG3275	phosphorelay sensor kinase activity
BIZ42_RS11600	COG3590	peptidase
BIZ42_RS11605	COG5001	Diguanylate cyclase
BIZ42_RS11615	COG3384	dioxygenase
BIZ42_RS11620	COG0025	NhaP-type Na H and K H
BIZ42_RS11655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ42_RS11675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIZ42_RS11690	COG2205	protein histidine kinase activity
BIZ42_RS11690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BIZ42_RS11710	COG1187	pseudouridine synthase activity
BIZ42_RS11715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BIZ42_RS11730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BIZ42_RS11770	COG1956	GAF domain-containing protein
BIZ42_RS11775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BIZ42_RS11780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BIZ42_RS11785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ42_RS11790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ42_RS11790	COG0785	Cytochrome C biogenesis protein
BIZ42_RS11795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ42_RS11800	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS11805	COG2205	protein histidine kinase activity
BIZ42_RS11815	COG0720	synthase
BIZ42_RS11820	COG4206	TonB-dependent receptor
BIZ42_RS11840	COG0513	Belongs to the DEAD box helicase family
BIZ42_RS11850	COG0625	glutathione transferase activity
BIZ42_RS11880	COG0626	cystathionine gamma-synthase activity
BIZ42_RS11910	COG1215	transferase activity, transferring glycosyl groups
BIZ42_RS11915	COG0463	Glycosyl transferase, family 2
BIZ42_RS11955	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BIZ42_RS11955	COG0662	Cupin 2, conserved barrel domain protein
BIZ42_RS11960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BIZ42_RS11990	COG1127	ABC transporter
BIZ42_RS11995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BIZ42_RS12010	COG0442	prolyl-tRNA aminoacylation
BIZ42_RS12020	COG1183	phosphatidylcholine synthase activity
BIZ42_RS12035	COG0525	valine-tRNA ligase activity
BIZ42_RS12050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BIZ42_RS12060	COG0795	lipopolysaccharide-transporting ATPase activity
BIZ42_RS12070	COG4974	Belongs to the 'phage' integrase family
BIZ42_RS12085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BIZ42_RS12085	COG0047	phosphoribosylformylglycinamidine synthase activity
BIZ42_RS12090	COG5295	Hep Hag repeat protein
BIZ42_RS12095	COG1404	Belongs to the peptidase S8 family
BIZ42_RS12100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BIZ42_RS12105	COG1459	type II secretion system
BIZ42_RS12110	COG2165	general secretion pathway protein
BIZ42_RS12115	COG4970	Tfp pilus assembly protein FimT
BIZ42_RS12120	COG2165	general secretion pathway protein
BIZ42_RS12125	COG4795	General secretion pathway protein
BIZ42_RS12130	COG3156	type II secretion system protein K
BIZ42_RS12135	COG3166	PFAM Fimbrial assembly family protein
BIZ42_RS12150	COG1450	Type ii and iii secretion system protein
BIZ42_RS12160	COG0463	Glycosyl transferase, family 2
BIZ42_RS12165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BIZ42_RS12180	COG1215	transferase activity, transferring glycosyl groups
BIZ42_RS12185	COG1215	transferase activity, transferring glycosyl groups
BIZ42_RS12190	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BIZ42_RS12195	COG0457	Tetratricopeptide repeat
BIZ42_RS12200	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BIZ42_RS12205	COG2252	PERMEase
BIZ42_RS12210	COG0488	(ABC) transporter
BIZ42_RS12220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BIZ42_RS12230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BIZ42_RS12235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIZ42_RS12235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BIZ42_RS12250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BIZ42_RS12255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BIZ42_RS12265	COG3121	Chaperone
BIZ42_RS12275	COG3188	usher protein
BIZ42_RS12295	COG0277	FAD linked oxidase domain protein
BIZ42_RS12325	COG2001	Belongs to the MraZ family
BIZ42_RS12330	COG0275	rRNA processing
BIZ42_RS12335	COG3116	cell division
BIZ42_RS12345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BIZ42_RS12350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BIZ42_RS12365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BIZ42_RS12375	COG1181	Belongs to the D-alanine--D-alanine ligase family
BIZ42_RS12380	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BIZ42_RS12390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BIZ42_RS12395	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BIZ42_RS12400	COG0739	heme binding
BIZ42_RS12405	COG0653	protein targeting
BIZ42_RS12410	COG0494	nUDIX hydrolase
BIZ42_RS12420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BIZ42_RS12425	COG1090	epimerase
BIZ42_RS12430	COG0596	Alpha beta hydrolase
BIZ42_RS12435	COG3275	phosphorelay sensor kinase activity
BIZ42_RS12440	COG3279	Response regulator of the LytR AlgR family
BIZ42_RS12455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BIZ42_RS12460	COG0457	Tetratricopeptide repeat
BIZ42_RS12465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BIZ42_RS12475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BIZ42_RS12480	COG1607	acyl-coa hydrolase
BIZ42_RS12485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BIZ42_RS12505	COG4106	trans-aconitate 2-methyltransferase activity
BIZ42_RS12510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BIZ42_RS12545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BIZ42_RS12550	COG0667	Aldo Keto reductase
BIZ42_RS12570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BIZ42_RS12575	COG4181	ATPase activity
BIZ42_RS12590	COG0642	Histidine kinase
BIZ42_RS12600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BIZ42_RS12605	COG0861	Integral membrane protein TerC family
BIZ42_RS12625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BIZ42_RS12630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BIZ42_RS12640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BIZ42_RS12645	COG2967	ApaG domain
BIZ42_RS12650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BIZ42_RS12655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BIZ42_RS12665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BIZ42_RS12675	COG2096	Adenosyltransferase
BIZ42_RS12685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BIZ42_RS12690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BIZ42_RS12700	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BIZ42_RS12710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BIZ42_RS12720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BIZ42_RS12730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIZ42_RS12735	COG0583	DNA-binding transcription factor activity
BIZ42_RS12740	COG3634	alkyl hydroperoxide reductase activity
BIZ42_RS12760	COG0583	DNA-binding transcription factor activity
BIZ42_RS12820	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BIZ42_RS12830	COG2151	metal-sulfur cluster biosynthetic enzyme
BIZ42_RS12835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BIZ42_RS12840	COG1404	Belongs to the peptidase S8 family
BIZ42_RS12860	COG1295	ribonuclease BN
BIZ42_RS12865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BIZ42_RS12880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BIZ42_RS12885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BIZ42_RS12900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BIZ42_RS12910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BIZ42_RS12920	COG0193	aminoacyl-tRNA hydrolase activity
BIZ42_RS12925	COG0012	GTP binding
BIZ42_RS12930	COG4206	TonB-dependent receptor
BIZ42_RS12940	COG1446	asparaginase
BIZ42_RS12960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BIZ42_RS12970	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BIZ42_RS12975	COG0250	Participates in transcription elongation, termination and antitermination
BIZ42_RS12980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BIZ42_RS12985	COG0081	regulation of translation
BIZ42_RS12990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BIZ42_RS12995	COG0222	ribosome binding
BIZ42_RS13000	COG0085	RNA polymerase activity
BIZ42_RS13005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BIZ42_RS13020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BIZ42_RS13025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BIZ42_RS13030	COG0051	transcription antitermination factor activity, RNA binding
BIZ42_RS13035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BIZ42_RS13040	COG0088	Forms part of the polypeptide exit tunnel
BIZ42_RS13045	COG0089	rRNA binding
BIZ42_RS13050	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BIZ42_RS13055	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BIZ42_RS13060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BIZ42_RS13065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BIZ42_RS13070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BIZ42_RS13075	COG0255	Belongs to the universal ribosomal protein uL29 family
BIZ42_RS13080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BIZ42_RS13090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BIZ42_RS13095	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BIZ42_RS13100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BIZ42_RS13105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BIZ42_RS13115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BIZ42_RS13125	COG1841	ribosomal large subunit assembly
BIZ42_RS13135	COG0201	protein transport
BIZ42_RS13145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BIZ42_RS13150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BIZ42_RS13155	COG0202	RNA polymerase activity
BIZ42_RS13160	COG0203	ribosomal protein L17
BIZ42_RS13165	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BIZ42_RS13175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BIZ42_RS13185	COG0154	amidase activity
BIZ42_RS13200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BIZ42_RS13205	COG0039	L-malate dehydrogenase activity
BIZ42_RS13210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BIZ42_RS13225	COG0625	glutathione transferase activity
BIZ42_RS13235	COG0446	pyridine nucleotide-disulphide oxidoreductase
BIZ42_RS13235	COG1902	pentaerythritol trinitrate reductase activity
BIZ42_RS13240	COG2364	Membrane
BIZ42_RS13260	COG1187	pseudouridine synthase activity
BIZ42_RS13270	COG0156	8-amino-7-oxononanoate synthase activity
BIZ42_RS13280	COG1063	alcohol dehydrogenase
BIZ42_RS13290	COG0588	phosphoglycerate mutase activity
BIZ42_RS13295	COG0285	dihydrofolate synthase activity
BIZ42_RS13305	COG1286	toxin biosynthetic process
BIZ42_RS13315	COG2833	Protein of unknown function (DUF455)
BIZ42_RS13325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BIZ42_RS13330	COG0671	phosphoesterase, PA-phosphatase related
BIZ42_RS13335	COG0438	transferase activity, transferring glycosyl groups
BIZ42_RS13340	COG4206	TonB-dependent receptor
BIZ42_RS13345	COG0248	Ppx GppA phosphatase
BIZ42_RS13350	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BIZ42_RS13365	COG4783	chaperone-mediated protein folding
BIZ42_RS13380	COG0473	3-isopropylmalate dehydrogenase activity
BIZ42_RS13440	COG0544	peptidyl-prolyl cis-trans isomerase activity
BIZ42_RS13450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BIZ42_RS13485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BIZ42_RS13490	COG1388	LysM domain
BIZ42_RS13490	COG3942	CHAP domain
BIZ42_RS13495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ42_RS13505	COG0328	RNA-DNA hybrid ribonuclease activity
BIZ42_RS13510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BIZ42_RS13515	COG0631	protein serine/threonine phosphatase activity
BIZ42_RS13550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BIZ42_RS13595	COG5377	YqaJ viral recombinase family
BIZ42_RS13625	COG1573	uracil-dna glycosylase
BIZ42_RS13660	COG4983	Phage plasmid primase, P4 family domain protein
BIZ42_RS13685	COG0582	viral genome integration into host DNA
BIZ42_RS13695	COG0859	PFAM glycosyl transferase family 9
BIZ42_RS13700	COG3642	lipopolysaccharide core region biosynthetic process
BIZ42_RS13705	COG1234	tRNA 3'-trailer cleavage
BIZ42_RS13750	COG0537	adenosine 5'-monophosphoramidase activity
BIZ42_RS13770	COG0714	Associated with various cellular activities
BIZ42_RS13790	COG1399	metal-binding, possibly nucleic acid-binding protein
BIZ42_RS13795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BIZ42_RS13800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BIZ42_RS13810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BIZ42_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS13825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BIZ42_RS13830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BIZ42_RS13835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BIZ42_RS13840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BIZ42_RS13870	COG1073	alpha beta
BIZ42_RS13880	COG0656	L-ascorbic acid biosynthetic process
BIZ42_RS13895	COG0667	Aldo Keto reductase
BIZ42_RS13900	COG3279	Response regulator of the LytR AlgR family
BIZ42_RS13920	COG0393	Putative heavy-metal-binding
BIZ42_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS13950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ42_RS14000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BIZ42_RS14040	COG0519	Catalyzes the synthesis of GMP from XMP
BIZ42_RS14045	COG1678	Uncharacterized ACR, COG1678
BIZ42_RS14050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BIZ42_RS14055	COG0540	Belongs to the ATCase OTCase family
BIZ42_RS14070	COG2239	Acts as a magnesium transporter
BIZ42_RS14075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BIZ42_RS14090	COG1660	Displays ATPase and GTPase activities
BIZ42_RS14095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BIZ42_RS14100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BIZ42_RS14115	COG1137	ATPase activity
BIZ42_RS14120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BIZ42_RS14130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BIZ42_RS14145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BIZ42_RS14165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BIZ42_RS14175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BIZ42_RS14185	COG0628	permease
BIZ42_RS14195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BIZ42_RS14205	COG2261	transglycosylase associated protein
BIZ42_RS14215	COG1555	photosystem II stabilization
BIZ42_RS14235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BIZ42_RS14260	COG4771	TonB-dependent receptor
BIZ42_RS14280	COG4774	siderophore transport
BIZ42_RS14290	COG2146	nitrite reductase [NAD(P)H] activity
BIZ42_RS14300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BIZ42_RS14305	COG0719	Fe-S assembly protein
BIZ42_RS14310	COG0396	ATPase activity
BIZ42_RS14320	COG0719	Fe-S assembly protein
BIZ42_RS14325	COG1959	2 iron, 2 sulfur cluster binding
BIZ42_RS14335	COG0693	protein deglycase activity
BIZ42_RS14355	COG1764	response to oxidative stress
BIZ42_RS14365	COG0384	phenazine biosynthesis protein PhzF
BIZ42_RS14370	COG0527	aspartate kinase activity
BIZ42_RS14395	COG0142	geranyltranstransferase activity
BIZ42_RS14400	COG0366	Alpha amylase catalytic
BIZ42_RS14410	COG1082	Xylose isomerase domain protein TIM barrel
BIZ42_RS14420	COG2190	(PTS) system
BIZ42_RS14420	COG2211	Major facilitator Superfamily
BIZ42_RS14445	COG1131	(ABC) transporter
BIZ42_RS14465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIZ42_RS14475	COG0629	single-stranded DNA binding
BIZ42_RS14500	COG2010	Cytochrome c
BIZ42_RS14510	COG0673	inositol 2-dehydrogenase activity
BIZ42_RS14515	COG2211	Major facilitator Superfamily
BIZ42_RS14525	COG1609	Transcriptional regulator
BIZ42_RS14545	COG1408	metallophosphoesterase
BIZ42_RS14575	COG0477	Major facilitator Superfamily
BIZ42_RS14585	COG0579	oxidoreductase
BIZ42_RS14595	COG0583	DNA-binding transcription factor activity
BIZ42_RS14615	COG3104	oligopeptide transport
BIZ42_RS14625	COG1297	OPT oligopeptide transporter protein
BIZ42_RS14630	COG0823	Involved in the tonB-independent uptake of proteins
BIZ42_RS14630	COG1506	peptidase
BIZ42_RS14645	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BIZ42_RS14650	COG2894	cell division
BIZ42_RS14665	COG4585	Histidine kinase
BIZ42_RS14670	COG2197	response regulator
BIZ42_RS14685	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BIZ42_RS14715	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BIZ42_RS14725	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BIZ42_RS14735	COG1595	DNA-templated transcription, initiation
BIZ42_RS14745	COG1946	Acyl-CoA thioesterase
BIZ42_RS14750	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ42_RS14750	COG1024	Enoyl-CoA hydratase
BIZ42_RS14760	COG0824	Thioesterase
BIZ42_RS14765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BIZ42_RS14775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BIZ42_RS14780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BIZ42_RS14790	COG0728	peptidoglycan biosynthetic process
BIZ42_RS14795	COG0196	riboflavin kinase activity
BIZ42_RS14800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BIZ42_RS14810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BIZ42_RS14840	COG3209	COG3209 Rhs family protein
BIZ42_RS14855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ42_RS14870	COG0596	Alpha beta hydrolase
BIZ42_RS14880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BIZ42_RS14890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BIZ42_RS14895	COG1845	cytochrome c oxidase, subunit III
BIZ42_RS14900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BIZ42_RS14930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BIZ42_RS14955	COG0336	Belongs to the RNA methyltransferase TrmD family
BIZ42_RS14960	COG0335	large ribosomal subunit rRNA binding
BIZ42_RS14970	COG0534	Mate efflux family protein
BIZ42_RS14975	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BIZ42_RS14980	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BIZ42_RS14990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BIZ42_RS15015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BIZ42_RS15030	COG4942	peptidase
BIZ42_RS15030	COG1388	LysM domain
BIZ42_RS15040	COG4716	Myosin-crossreactive antigen
BIZ42_RS15050	COG0515	serine threonine protein kinase
BIZ42_RS15050	COG2815	serine threonine protein kinase
BIZ42_RS15065	COG3706	GGDEF domain
BIZ42_RS15075	COG0588	phosphoglycerate mutase activity
BIZ42_RS15080	COG3590	peptidase
BIZ42_RS15090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BIZ42_RS15100	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BIZ42_RS15105	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS15110	COG2205	protein histidine kinase activity
BIZ42_RS15115	COG4452	Inner membrane protein CreD
BIZ42_RS15140	COG0735	belongs to the Fur family
BIZ42_RS15235	COG5002	protein histidine kinase activity
BIZ42_RS15235	COG5001	Diguanylate cyclase
BIZ42_RS15245	COG1187	pseudouridine synthase activity
BIZ42_RS15250	COG3706	GGDEF domain
BIZ42_RS15275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIZ42_RS15280	COG1132	(ABC) transporter
BIZ42_RS15300	COG0583	DNA-binding transcription factor activity
BIZ42_RS15340	COG1981	membrane
BIZ42_RS15345	COG0825	malonyl-CoA metabolic process
BIZ42_RS15365	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BIZ42_RS15370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BIZ42_RS15380	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BIZ42_RS15395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BIZ42_RS15400	COG0575	Belongs to the CDS family
BIZ42_RS15405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BIZ42_RS15415	COG0528	UMP kinase activity
BIZ42_RS15430	COG0052	Belongs to the universal ribosomal protein uS2 family
BIZ42_RS15450	COG3188	usher protein
BIZ42_RS15465	COG0024	Methionine aminopeptidase
BIZ42_RS15470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BIZ42_RS15485	COG1393	Belongs to the ArsC family
BIZ42_RS15490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BIZ42_RS15505	COG0367	asparagine synthase
BIZ42_RS15510	COG0475	glutathione-regulated potassium exporter activity
BIZ42_RS15545	COG1566	PFAM secretion protein HlyD family protein
BIZ42_RS15550	COG2814	Major facilitator Superfamily
BIZ42_RS15570	COG0557	exoribonuclease II activity
BIZ42_RS15580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BIZ42_RS15585	COG1538	Outer membrane efflux protein
BIZ42_RS15590	COG0577	efflux transmembrane transporter activity
BIZ42_RS15590	COG1136	(ABC) transporter
BIZ42_RS15595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BIZ42_RS15615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BIZ42_RS15625	COG3220	belongs to the UPF0276 family
BIZ42_RS15635	COG0704	Plays a role in the regulation of phosphate uptake
BIZ42_RS15645	COG0581	inorganic phosphate transmembrane transporter activity
BIZ42_RS15650	COG0573	inorganic phosphate transmembrane transporter activity
BIZ42_RS15655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BIZ42_RS15660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BIZ42_RS15665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BIZ42_RS15685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BIZ42_RS15695	COG1024	Enoyl-CoA hydratase
BIZ42_RS15725	COG0116	Belongs to the methyltransferase superfamily
BIZ42_RS15725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BIZ42_RS15770	COG2733	membrane
BIZ42_RS15780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BIZ42_RS15785	COG1012	belongs to the aldehyde dehydrogenase family
BIZ42_RS15795	COG0477	Major facilitator Superfamily
BIZ42_RS15800	COG2703	oxygen carrier activity
BIZ42_RS15815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BIZ42_RS15820	COG0174	glutamine synthetase
BIZ42_RS15830	COG3842	ATPase activity
BIZ42_RS15835	COG1176	ABC-type spermidine putrescine transport system, permease component I
BIZ42_RS15840	COG1177	transmembrane transport
BIZ42_RS15845	COG1012	belongs to the aldehyde dehydrogenase family
BIZ42_RS15860	COG4535	Mg2 and Co2 transporter CorC
BIZ42_RS15875	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BIZ42_RS15880	COG1702	phosphate starvation-inducible protein PhoH
BIZ42_RS15885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BIZ42_RS15890	COG0741	lytic transglycosylase activity
BIZ42_RS15895	COG0723	plastoquinol--plastocyanin reductase activity
BIZ42_RS15900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BIZ42_RS15905	COG2857	Cytochrome c1
BIZ42_RS15910	COG0625	glutathione transferase activity
BIZ42_RS15915	COG2969	positive regulation of protein catabolic process
BIZ42_RS15955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BIZ42_RS15960	COG0300	oxidoreductase activity
BIZ42_RS15970	COG1611	Belongs to the LOG family
BIZ42_RS16000	COG4968	Prepilin-type N-terminal cleavage methylation domain
BIZ42_RS16015	COG0556	nucleotide-excision repair
BIZ42_RS16035	COG0811	peptide transport
BIZ42_RS16050	COG1663	tetraacyldisaccharide 4'-kinase activity
BIZ42_RS16055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BIZ42_RS16065	COG0322	excinuclease ABC activity
BIZ42_RS16070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BIZ42_RS16230	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BIZ42_RS16280	COG4695	Portal protein
BIZ42_RS16285	COG0740	serine-type endopeptidase activity
BIZ42_RS16395	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BIZ42_RS16415	COG0348	domain, Protein
BIZ42_RS16430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BIZ42_RS16450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BIZ42_RS16455	COG0069	glutamate synthase activity
BIZ42_RS16485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BIZ42_RS16500	COG1253	flavin adenine dinucleotide binding
BIZ42_RS16510	COG0306	phosphate transporter
BIZ42_RS16515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BIZ42_RS16535	COG0504	CTP synthase activity
BIZ42_RS16540	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BIZ42_RS16550	COG0148	phosphopyruvate hydratase activity
BIZ42_RS16555	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BIZ42_RS16560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BIZ42_RS16575	COG2840	Smr protein MutS2
BIZ42_RS16580	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BIZ42_RS16585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BIZ42_RS16590	COG1238	metal cluster binding
BIZ42_RS16605	COG1534	Rna-binding protein
BIZ42_RS16610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BIZ42_RS16615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BIZ42_RS16625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BIZ42_RS16630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BIZ42_RS16635	COG1923	regulation of RNA biosynthetic process
BIZ42_RS16640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BIZ42_RS16645	COG1546	Belongs to the CinA family
BIZ42_RS16655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BIZ42_RS16665	COG2137	regulation of response to DNA damage stimulus
BIZ42_RS16670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BIZ42_RS16675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BIZ42_RS16700	COG1741	Belongs to the pirin family
BIZ42_RS16705	COG0583	DNA-binding transcription factor activity
BIZ42_RS16735	COG0352	thiamine-phosphate diphosphorylase activity
BIZ42_RS16735	COG0351	phosphomethylpyrimidine kinase
BIZ42_RS16750	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BIZ42_RS16755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BIZ42_RS16765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BIZ42_RS16775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BIZ42_RS16800	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS16830	COG1501	Belongs to the glycosyl hydrolase 31 family
BIZ42_RS16840	COG1070	Carbohydrate kinase
BIZ42_RS16850	COG0477	Major facilitator Superfamily
BIZ42_RS16860	COG0617	tRNA 3'-terminal CCA addition
BIZ42_RS16865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BIZ42_RS16870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BIZ42_RS16875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BIZ42_RS16885	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BIZ42_RS16890	COG0166	Belongs to the GPI family
BIZ42_RS16895	COG1472	Belongs to the glycosyl hydrolase 3 family
BIZ42_RS16905	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BIZ42_RS16915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BIZ42_RS16920	COG0671	phosphoesterase, PA-phosphatase related
BIZ42_RS16935	COG0129	dihydroxy-acid dehydratase activity
BIZ42_RS16940	COG0363	glucosamine-6-phosphate deaminase activity
BIZ42_RS16945	COG0837	glucose binding
BIZ42_RS16950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BIZ42_RS16955	COG3842	ATPase activity
BIZ42_RS16960	COG0354	folic acid binding
BIZ42_RS16965	COG2009	succinate dehydrogenase
BIZ42_RS16970	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BIZ42_RS16980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BIZ42_RS16985	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BIZ42_RS16995	COG4591	ABC-type transport system involved in lipoprotein release permease component
BIZ42_RS17000	COG1136	(ABC) transporter
BIZ42_RS17010	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BIZ42_RS17015	COG1194	a g-specific adenine glycosylase
BIZ42_RS17020	COG0552	protein localization to endoplasmic reticulum
BIZ42_RS17030	COG0326	Molecular chaperone. Has ATPase activity
BIZ42_RS17035	COG0742	ribosomal rna small subunit methyltransferase
BIZ42_RS17050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BIZ42_RS17055	COG0405	Gamma-glutamyltransferase
BIZ42_RS17060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BIZ42_RS17070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BIZ42_RS17090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BIZ42_RS17100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BIZ42_RS17105	COG0415	Belongs to the DNA photolyase family
BIZ42_RS17110	COG3047	cAMP biosynthetic process
BIZ42_RS17110	COG2885	chlorophyll binding
BIZ42_RS17120	COG0583	DNA-binding transcription factor activity
BIZ42_RS17180	COG0477	Major facilitator Superfamily
BIZ42_RS17230	COG0582	viral genome integration into host DNA
BIZ42_RS17250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BIZ42_RS17260	COG2914	Belongs to the UPF0125 (RnfH) family
BIZ42_RS17265	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BIZ42_RS17280	COG0583	DNA-binding transcription factor activity
BIZ42_RS17285	COG0497	DNA recombination
BIZ42_RS17290	COG1420	regulation of RNA biosynthetic process
BIZ42_RS17295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BIZ42_RS17300	COG0443	Heat shock 70 kDa protein
BIZ42_RS17305	COG0484	heat shock protein binding
BIZ42_RS17320	COG1605	Chorismate mutase
BIZ42_RS17320	COG0287	Prephenate dehydrogenase
BIZ42_RS17330	COG1132	(ABC) transporter
BIZ42_RS17360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BIZ42_RS17365	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BIZ42_RS17375	COG1862	Preprotein translocase
BIZ42_RS17380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIZ42_RS17385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BIZ42_RS17390	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BIZ42_RS17400	COG2081	HI0933 family
BIZ42_RS17405	COG4681	YaeQ
BIZ42_RS17410	COG0564	pseudouridine synthase activity
BIZ42_RS17425	COG0625	glutathione transferase activity
BIZ42_RS17430	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BIZ42_RS17435	COG3420	alginic acid biosynthetic process
BIZ42_RS17445	COG0710	3-dehydroquinate dehydratase activity
BIZ42_RS17460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BIZ42_RS17470	COG3485	protocatechuate 3,4-dioxygenase
BIZ42_RS17475	COG3485	protocatechuate 3,4-dioxygenase
BIZ42_RS17485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BIZ42_RS17490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BIZ42_RS17495	COG1414	Transcriptional regulator
BIZ42_RS17510	COG0513	Belongs to the DEAD box helicase family
BIZ42_RS17520	COG0583	DNA-binding transcription factor activity
BIZ42_RS17525	COG0488	(ABC) transporter
BIZ42_RS17550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BIZ42_RS17565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BIZ42_RS17570	COG2957	Belongs to the agmatine deiminase family
BIZ42_RS17580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BIZ42_RS17585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BIZ42_RS17590	COG0539	negative regulation of cytoplasmic translation
BIZ42_RS17595	COG0776	regulation of translation
BIZ42_RS17605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BIZ42_RS17620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BIZ42_RS17625	COG0183	Belongs to the thiolase family
BIZ42_RS17630	COG1024	Enoyl-CoA hydratase
BIZ42_RS17630	COG1250	3-hydroxyacyl-CoA dehydrogenase
BIZ42_RS17640	COG0105	UTP biosynthetic process
BIZ42_RS17645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BIZ42_RS17655	COG1426	Protein conserved in bacteria
BIZ42_RS17660	COG2976	Protein conserved in bacteria
BIZ42_RS17665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BIZ42_RS17670	COG1160	GTP binding
BIZ42_RS17675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BIZ42_RS17680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BIZ42_RS17680	COG0475	glutathione-regulated potassium exporter activity
BIZ42_RS17695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BIZ42_RS17695	COG0519	Catalyzes the synthesis of GMP from XMP
BIZ42_RS17715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BIZ42_RS17740	COG0583	DNA-binding transcription factor activity
BIZ42_RS17760	COG0022	dehydrogenase e1 component
BIZ42_RS17770	COG0583	DNA-binding transcription factor activity
BIZ42_RS17775	COG3949	Membrane
BIZ42_RS17790	COG4771	TonB-dependent receptor
BIZ42_RS17795	COG3104	oligopeptide transport
BIZ42_RS17805	COG4948	Mandelate Racemase Muconate Lactonizing
BIZ42_RS17810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BIZ42_RS17840	COG0697	spore germination
BIZ42_RS17845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BIZ42_RS17850	COG0167	dihydroorotate dehydrogenase activity
BIZ42_RS17865	COG1028	Short-chain dehydrogenase reductase Sdr
BIZ42_RS17875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BIZ42_RS17885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BIZ42_RS17910	COG0438	transferase activity, transferring glycosyl groups
BIZ42_RS17925	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BIZ42_RS17965	COG2323	membrane
BIZ42_RS18030	COG0460	homoserine dehydrogenase
BIZ42_RS18030	COG0527	aspartate kinase activity
BIZ42_RS18045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BIZ42_RS18050	COG0124	histidyl-tRNA synthetase
BIZ42_RS18070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BIZ42_RS18085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BIZ42_RS18090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BIZ42_RS18095	COG0107	imidazoleglycerol-phosphate synthase activity
BIZ42_RS18100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BIZ42_RS18100	COG0140	phosphoribosyl-ATP diphosphatase activity
BIZ42_RS18115	COG1446	asparaginase
BIZ42_RS18120	COG3142	Participates in the control of copper homeostasis
BIZ42_RS18130	COG3537	Alpha-1,2-mannosidase
BIZ42_RS18135	COG1609	Transcriptional regulator
BIZ42_RS18145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BIZ42_RS18160	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BIZ42_RS18165	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BIZ42_RS18170	COG0235	Class ii aldolase
BIZ42_RS18175	COG0531	amino acid
BIZ42_RS18180	COG0531	amino acid
BIZ42_RS18190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BIZ42_RS18195	COG0277	FAD linked oxidase domain protein
BIZ42_RS18210	COG2205	protein histidine kinase activity
BIZ42_RS18215	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS18235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BIZ42_RS18245	COG3300	MHYT domain
BIZ42_RS18245	COG5001	Diguanylate cyclase
BIZ42_RS18280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BIZ42_RS18285	COG0505	Belongs to the CarA family
BIZ42_RS18295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BIZ42_RS18300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BIZ42_RS18310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BIZ42_RS18335	COG4676	Protein conserved in bacteria
BIZ42_RS18340	COG0671	phosphoesterase, PA-phosphatase related
BIZ42_RS18355	COG0501	Belongs to the peptidase M48B family
BIZ42_RS18360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BIZ42_RS18365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BIZ42_RS18375	COG0784	Response regulator, receiver
BIZ42_RS18375	COG2198	Histidine kinase
BIZ42_RS18375	COG2205	protein histidine kinase activity
BIZ42_RS18380	COG1024	Enoyl-CoA hydratase
BIZ42_RS18385	COG0318	PFAM AMP-dependent synthetase and ligase
BIZ42_RS18420	COG0583	DNA-binding transcription factor activity
BIZ42_RS18425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BIZ42_RS18435	COG1301	dicarboxylic acid transport
BIZ42_RS18445	COG2159	amidohydrolase
BIZ42_RS18460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BIZ42_RS18465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BIZ42_RS18470	COG0840	transmembrane signaling receptor activity
BIZ42_RS18475	COG0840	transmembrane signaling receptor activity
BIZ42_RS18485	COG0835	chemotaxis
BIZ42_RS18490	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BIZ42_RS18495	COG0840	transmembrane signaling receptor activity
BIZ42_RS18505	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS18515	COG0835	chemotaxis
BIZ42_RS18525	COG1360	Flagellar Motor Protein
BIZ42_RS18530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BIZ42_RS18535	COG2198	Histidine kinase
BIZ42_RS18535	COG0643	Histidine kinase
BIZ42_RS18535	COG0784	Response regulator, receiver
BIZ42_RS18540	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BIZ42_RS18565	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIZ42_RS18570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BIZ42_RS18580	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BIZ42_RS18580	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BIZ42_RS18590	COG0542	response to heat
BIZ42_RS18605	COG1987	bacterial-type flagellum assembly
BIZ42_RS18615	COG3190	flagellar
BIZ42_RS18680	COG2201	protein-glutamate methylesterase activity
BIZ42_RS18685	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BIZ42_RS18690	COG2197	response regulator
BIZ42_RS18735	COG1256	bacterial-type flagellum assembly
BIZ42_RS18735	COG4786	Flagellar basal body rod
BIZ42_RS18750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BIZ42_RS18760	COG4787	bacterial-type flagellum-dependent cell motility
BIZ42_RS18785	COG0835	chemotaxis
BIZ42_RS18785	COG0784	Response regulator, receiver
BIZ42_RS18805	COG5002	protein histidine kinase activity
BIZ42_RS18845	COG2915	High frequency lysogenization protein hflD homolog
BIZ42_RS18850	COG0482	sulfurtransferase activity
BIZ42_RS18865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BIZ42_RS18870	COG0542	response to heat
BIZ42_RS18895	COG0492	ferredoxin-NADP+ reductase activity
BIZ42_RS18900	COG1674	ftsk spoiiie
BIZ42_RS18910	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BIZ42_RS18920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BIZ42_RS18940	COG0625	glutathione transferase activity
BIZ42_RS18955	COG2249	NAD(P)H dehydrogenase (quinone) activity
BIZ42_RS18970	COG2819	hydrolase of the alpha beta superfamily
BIZ42_RS18980	COG4558	Periplasmic binding protein
BIZ42_RS18985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BIZ42_RS18990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BIZ42_RS18995	COG4774	siderophore transport
BIZ42_RS19000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BIZ42_RS19030	COG0745	RESPONSE REGULATOR receiver
BIZ42_RS19055	COG3459	Glycosyltransferase 36 associated
BIZ42_RS19060	COG2200	EAL domain