locus-tag	class	description
CLM74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLM74_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLM74_RS00020	COG0187	DNA topoisomerase II activity
CLM74_RS00025	COG1266	CAAX protease self-immunity
CLM74_RS00030	COG0501	Belongs to the peptidase M48B family
CLM74_RS00100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CLM74_RS00110	COG4772	TonB-dependent receptor
CLM74_RS00145	COG1012	belongs to the aldehyde dehydrogenase family
CLM74_RS00155	COG0800	Aldolase
CLM74_RS00160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLM74_RS00180	COG2272	Belongs to the type-B carboxylesterase lipase family
CLM74_RS00195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CLM74_RS00210	COG3507	Belongs to the glycosyl hydrolase 43 family
CLM74_RS00215	COG1609	Transcriptional regulator
CLM74_RS00225	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS00230	COG2755	lipolytic protein G-D-S-L family
CLM74_RS00240	COG3186	Phenylalanine-4-hydroxylase
CLM74_RS00245	COG1522	sequence-specific DNA binding
CLM74_RS00255	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLM74_RS00265	COG4771	TonB-dependent receptor
CLM74_RS00285	COG1122	ATPase activity
CLM74_RS00300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CLM74_RS00310	COG0515	serine threonine protein kinase
CLM74_RS00310	COG2815	serine threonine protein kinase
CLM74_RS00315	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CLM74_RS00325	COG1435	thymidine kinase activity
CLM74_RS00330	COG0210	DNA helicase
CLM74_RS00340	COG3132	Protein of unknown function, DUF480
CLM74_RS00345	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CLM74_RS00350	COG0284	orotidine-5'-phosphate decarboxylase activity
CLM74_RS00355	COG5640	endopeptidase activity
CLM74_RS00365	COG2937	Belongs to the GPAT DAPAT family
CLM74_RS00380	COG0037	tRNA processing
CLM74_RS00385	COG2974	May be involved in recombination
CLM74_RS00395	COG1803	Methylglyoxal synthase
CLM74_RS00400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLM74_RS00400	COG2205	protein histidine kinase activity
CLM74_RS00405	COG0493	'glutamate synthase
CLM74_RS00410	COG0069	glutamate synthase activity
CLM74_RS00410	COG0067	glutamate synthase
CLM74_RS00410	COG0070	glutamate synthase
CLM74_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS00435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLM74_RS00460	COG1111	helicase
CLM74_RS00460	COG1205	dead DEAH box helicase
CLM74_RS00495	COG0714	Associated with various cellular activities
CLM74_RS00515	COG0312	modulator of DNA gyrase
CLM74_RS00535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLM74_RS00555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLM74_RS00595	COG1968	undecaprenyl-diphosphatase activity
CLM74_RS00600	COG0174	glutamine synthetase
CLM74_RS00605	COG0347	Belongs to the P(II) protein family
CLM74_RS00610	COG0004	ammonium transporteR
CLM74_RS00620	COG3279	Response regulator of the LytR AlgR family
CLM74_RS00635	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CLM74_RS00650	COG3852	Histidine kinase
CLM74_RS00655	COG2204	response regulator
CLM74_RS00660	COG2032	superoxide dismutase activity
CLM74_RS00665	COG2032	superoxide dismutase activity
CLM74_RS00680	COG0183	Belongs to the thiolase family
CLM74_RS00715	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CLM74_RS00720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLM74_RS00755	COG1309	transcriptional regulator
CLM74_RS00760	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS00765	COG2207	Transcriptional regulator
CLM74_RS00825	COG2837	iron assimilation
CLM74_RS00865	COG2197	response regulator
CLM74_RS00870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLM74_RS00870	COG2205	protein histidine kinase activity
CLM74_RS00875	COG3474	cytochrome
CLM74_RS00885	COG1960	acyl-CoA dehydrogenase activity
CLM74_RS00890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLM74_RS00900	COG0612	Peptidase, M16
CLM74_RS00910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM74_RS00915	COG0596	Alpha beta hydrolase
CLM74_RS00925	COG0318	PFAM AMP-dependent synthetase and ligase
CLM74_RS00930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLM74_RS00940	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLM74_RS00955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLM74_RS00960	COG4122	O-methyltransferase activity
CLM74_RS00965	COG0564	pseudouridine synthase activity
CLM74_RS00985	COG0339	signal peptide processing
CLM74_RS01000	COG0681	Belongs to the peptidase S26 family
CLM74_RS01005	COG2814	Major facilitator Superfamily
CLM74_RS01010	COG0583	DNA-binding transcription factor activity
CLM74_RS01015	COG0583	DNA-binding transcription factor activity
CLM74_RS01020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CLM74_RS01025	COG2224	Isocitrate lyase
CLM74_RS01055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLM74_RS01060	COG1960	acyl-CoA dehydrogenase activity
CLM74_RS01085	COG0697	spore germination
CLM74_RS01095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CLM74_RS01105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLM74_RS01110	COG1280	lysine exporter protein (LysE YggA)
CLM74_RS01115	COG1607	acyl-coa hydrolase
CLM74_RS01125	COG1902	pentaerythritol trinitrate reductase activity
CLM74_RS01155	COG1335	isochorismatase
CLM74_RS01160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLM74_RS01165	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLM74_RS01175	COG1396	sequence-specific DNA binding
CLM74_RS01175	COG3800	Transcriptional regulator
CLM74_RS01185	COG1960	acyl-CoA dehydrogenase activity
CLM74_RS01190	COG1024	Enoyl-CoA hydratase
CLM74_RS01195	COG1024	Enoyl-CoA hydratase
CLM74_RS01205	COG1764	response to oxidative stress
CLM74_RS01215	COG0659	secondary active sulfate transmembrane transporter activity
CLM74_RS01245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLM74_RS01275	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLM74_RS01275	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLM74_RS01280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLM74_RS01295	COG3657	addiction module killer protein
CLM74_RS01300	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLM74_RS01335	COG3237	CsbD-like
CLM74_RS01345	COG0180	Tryptophanyl-tRNA synthetase
CLM74_RS01365	COG0477	Major facilitator Superfamily
CLM74_RS01370	COG0697	spore germination
CLM74_RS01385	COG0577	efflux transmembrane transporter activity
CLM74_RS01385	COG1136	(ABC) transporter
CLM74_RS01395	COG1136	(ABC) transporter
CLM74_RS01400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM74_RS01410	COG4585	Histidine kinase
CLM74_RS01415	COG2197	response regulator
CLM74_RS01420	COG3038	cytochrome b561
CLM74_RS01430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLM74_RS01445	COG0628	permease
CLM74_RS01465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLM74_RS01480	COG5507	3-demethylubiquinone-9 3-methyltransferase
CLM74_RS01490	COG2771	luxR family
CLM74_RS01490	COG2200	EAL domain
CLM74_RS01505	COG2814	Major facilitator Superfamily
CLM74_RS01510	COG0583	DNA-binding transcription factor activity
CLM74_RS01515	COG4807	Protein conserved in bacteria
CLM74_RS01525	COG4221	oxidoreductase activity
CLM74_RS01535	COG0018	arginyl-trna synthetase
CLM74_RS01540	COG2003	Belongs to the UPF0758 family
CLM74_RS01545	COG2197	response regulator
CLM74_RS01550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLM74_RS01555	COG0756	dUTP diphosphatase activity
CLM74_RS01575	COG2205	protein histidine kinase activity
CLM74_RS01585	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CLM74_RS01590	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CLM74_RS01605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLM74_RS01610	COG0708	Exodeoxyribonuclease III
CLM74_RS01615	COG2223	nitrite transmembrane transporter activity
CLM74_RS01630	COG0739	heme binding
CLM74_RS01635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLM74_RS01695	COG2234	aminopeptidase activity
CLM74_RS01705	COG4942	peptidase
CLM74_RS01710	COG0793	Belongs to the peptidase S41A family
CLM74_RS01720	COG2067	long-chain fatty acid transport protein
CLM74_RS01755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CLM74_RS01760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CLM74_RS01800	COG0109	protoheme IX farnesyltransferase activity
CLM74_RS01815	COG0358	DNA primase activity
CLM74_RS01820	COG1295	ribonuclease BN
CLM74_RS01825	COG1610	YqeY-like protein
CLM74_RS01835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLM74_RS01845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLM74_RS01850	COG0668	transmembrane transport
CLM74_RS01865	COG2133	pyrroloquinoline quinone binding
CLM74_RS01870	COG4682	membrane
CLM74_RS01880	COG0531	amino acid
CLM74_RS01890	COG1737	Transcriptional regulator
CLM74_RS01895	COG4948	Mandelate Racemase Muconate Lactonizing
CLM74_RS01945	COG5383	Protein conserved in bacteria
CLM74_RS01955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CLM74_RS01960	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CLM74_RS01990	COG0778	Nitroreductase
CLM74_RS01995	COG2353	YceI-like domain
CLM74_RS02010	COG2375	cellular response to nickel ion
CLM74_RS02140	COG2267	carboxylic ester hydrolase activity
CLM74_RS02155	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CLM74_RS02200	COG0488	(ABC) transporter
CLM74_RS02205	COG0583	DNA-binding transcription factor activity
CLM74_RS02215	COG2814	Major facilitator Superfamily
CLM74_RS02220	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CLM74_RS02225	COG1113	amino acid transport
CLM74_RS02230	COG0741	lytic transglycosylase activity
CLM74_RS02255	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CLM74_RS02265	COG5507	3-demethylubiquinone-9 3-methyltransferase
CLM74_RS02270	COG4941	Belongs to the sigma-70 factor family
CLM74_RS02300	COG3275	phosphorelay sensor kinase activity
CLM74_RS02305	COG3279	Response regulator of the LytR AlgR family
CLM74_RS02325	COG3590	peptidase
CLM74_RS02330	COG5001	Diguanylate cyclase
CLM74_RS02335	COG0583	DNA-binding transcription factor activity
CLM74_RS02345	COG3384	dioxygenase
CLM74_RS02350	COG0025	NhaP-type Na H and K H
CLM74_RS02375	COG1360	Flagellar Motor Protein
CLM74_RS02405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM74_RS02420	COG2205	protein histidine kinase activity
CLM74_RS02435	COG2813	Specifically methylates the guanine in position
CLM74_RS02440	COG1187	pseudouridine synthase activity
CLM74_RS02445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLM74_RS02455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLM74_RS02460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLM74_RS02475	COG0583	DNA-binding transcription factor activity
CLM74_RS02480	COG2226	methyltransferase
CLM74_RS02505	COG1956	GAF domain-containing protein
CLM74_RS02510	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLM74_RS02515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM74_RS02520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLM74_RS02525	COG0785	Cytochrome C biogenesis protein
CLM74_RS02525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM74_RS02530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLM74_RS02535	COG0745	RESPONSE REGULATOR receiver
CLM74_RS02540	COG5002	protein histidine kinase activity
CLM74_RS02545	COG2205	protein histidine kinase activity
CLM74_RS02550	COG0745	RESPONSE REGULATOR receiver
CLM74_RS02560	COG0720	synthase
CLM74_RS02585	COG0513	Belongs to the DEAD box helicase family
CLM74_RS02600	COG0625	glutathione transferase activity
CLM74_RS02605	COG1573	uracil-dna glycosylase
CLM74_RS02640	COG0626	cystathionine gamma-synthase activity
CLM74_RS02660	COG1216	Glycosyl transferase, family 2
CLM74_RS02660	COG0438	transferase activity, transferring glycosyl groups
CLM74_RS02665	COG3754	Rhamnan synthesis protein F
CLM74_RS02675	COG2226	methyltransferase
CLM74_RS02710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLM74_RS02715	COG2226	methyltransferase
CLM74_RS02720	COG0300	oxidoreductase activity
CLM74_RS02725	COG0277	FAD linked oxidase domain protein
CLM74_RS02730	COG0546	phosphoglycolate phosphatase activity
CLM74_RS02730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CLM74_RS02745	COG2076	Multidrug Resistance protein
CLM74_RS02765	COG0463	Glycosyl transferase, family 2
CLM74_RS02785	COG2086	electron transfer activity
CLM74_RS02825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLM74_RS02860	COG1127	ABC transporter
CLM74_RS02865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLM74_RS02880	COG0442	prolyl-tRNA aminoacylation
CLM74_RS02900	COG1183	phosphatidylcholine synthase activity
CLM74_RS02920	COG0525	valine-tRNA ligase activity
CLM74_RS02935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLM74_RS02945	COG0795	lipopolysaccharide-transporting ATPase activity
CLM74_RS02955	COG4974	Belongs to the 'phage' integrase family
CLM74_RS02970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLM74_RS02970	COG0047	phosphoribosylformylglycinamidine synthase activity
CLM74_RS02980	COG1404	Belongs to the peptidase S8 family
CLM74_RS02985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLM74_RS02990	COG1459	type II secretion system
CLM74_RS02995	COG2165	general secretion pathway protein
CLM74_RS03000	COG4970	Tfp pilus assembly protein FimT
CLM74_RS03005	COG2165	general secretion pathway protein
CLM74_RS03010	COG4795	General secretion pathway protein
CLM74_RS03015	COG3156	type II secretion system protein K
CLM74_RS03020	COG3166	PFAM Fimbrial assembly family protein
CLM74_RS03035	COG1450	Type ii and iii secretion system protein
CLM74_RS03045	COG0463	Glycosyl transferase, family 2
CLM74_RS03065	COG2194	sulfuric ester hydrolase activity
CLM74_RS03080	COG1215	transferase activity, transferring glycosyl groups
CLM74_RS03085	COG1215	transferase activity, transferring glycosyl groups
CLM74_RS03090	COG3118	belongs to the thioredoxin family
CLM74_RS03090	COG0457	Tetratricopeptide repeat
CLM74_RS03095	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CLM74_RS03100	COG2252	PERMEase
CLM74_RS03110	COG0488	(ABC) transporter
CLM74_RS03125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLM74_RS03150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLM74_RS03155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLM74_RS03155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLM74_RS03205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLM74_RS03210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLM74_RS03240	COG3188	usher protein
CLM74_RS03270	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CLM74_RS03270	COG2755	lipolytic protein G-D-S-L family
CLM74_RS03275	COG0277	FAD linked oxidase domain protein
CLM74_RS03280	COG1988	membrane-bound metal-dependent
CLM74_RS03315	COG2001	Belongs to the MraZ family
CLM74_RS03320	COG0275	rRNA processing
CLM74_RS03325	COG3116	cell division
CLM74_RS03335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLM74_RS03340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLM74_RS03360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLM74_RS03365	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLM74_RS03370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CLM74_RS03380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLM74_RS03385	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CLM74_RS03395	COG0739	heme binding
CLM74_RS03400	COG0653	protein targeting
CLM74_RS03405	COG0494	nUDIX hydrolase
CLM74_RS03415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLM74_RS03440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLM74_RS03445	COG0457	Tetratricopeptide repeat
CLM74_RS03460	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CLM74_RS03475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CLM74_RS03480	COG1607	acyl-coa hydrolase
CLM74_RS03485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLM74_RS03505	COG4106	trans-aconitate 2-methyltransferase activity
CLM74_RS03510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLM74_RS03520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLM74_RS03525	COG0667	Aldo Keto reductase
CLM74_RS03535	COG4771	TonB-dependent receptor
CLM74_RS03550	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CLM74_RS03555	COG4181	ATPase activity
CLM74_RS03570	COG0642	Histidine kinase
CLM74_RS03580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLM74_RS03585	COG0861	Integral membrane protein TerC family
CLM74_RS03590	COG2814	Major facilitator Superfamily
CLM74_RS03595	COG1704	LemA family
CLM74_RS03610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLM74_RS03615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLM74_RS03630	COG3738	Protein conserved in bacteria
CLM74_RS03635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLM74_RS03640	COG2967	ApaG domain
CLM74_RS03650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CLM74_RS03660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CLM74_RS03670	COG2096	Adenosyltransferase
CLM74_RS03680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLM74_RS03685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLM74_RS03695	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CLM74_RS03710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLM74_RS03720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLM74_RS03725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLM74_RS03730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLM74_RS03735	COG0583	DNA-binding transcription factor activity
CLM74_RS03740	COG3634	alkyl hydroperoxide reductase activity
CLM74_RS03760	COG0583	DNA-binding transcription factor activity
CLM74_RS03800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CLM74_RS03825	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CLM74_RS03840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLM74_RS03845	COG1404	Belongs to the peptidase S8 family
CLM74_RS03865	COG1295	ribonuclease BN
CLM74_RS03870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM74_RS03885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLM74_RS03890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLM74_RS03905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLM74_RS03915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLM74_RS03925	COG0193	aminoacyl-tRNA hydrolase activity
CLM74_RS03935	COG0012	GTP binding
CLM74_RS03945	COG2197	response regulator
CLM74_RS03950	COG2205	protein histidine kinase activity
CLM74_RS03950	COG0784	Response regulator, receiver
CLM74_RS03955	COG2199	diguanylate cyclase activity
CLM74_RS03955	COG2200	EAL domain
CLM74_RS03955	COG2203	Gaf domain
CLM74_RS03960	COG0784	Response regulator, receiver
CLM74_RS03960	COG2205	protein histidine kinase activity
CLM74_RS03965	COG4206	TonB-dependent receptor
CLM74_RS03970	COG4242	Belongs to the peptidase S51 family
CLM74_RS03995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLM74_RS04010	COG0250	Participates in transcription elongation, termination and antitermination
CLM74_RS04015	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLM74_RS04020	COG0081	regulation of translation
CLM74_RS04030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLM74_RS04035	COG0222	ribosome binding
CLM74_RS04040	COG0085	RNA polymerase activity
CLM74_RS04045	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLM74_RS04060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLM74_RS04065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLM74_RS04070	COG0051	transcription antitermination factor activity, RNA binding
CLM74_RS04075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLM74_RS04080	COG0088	Forms part of the polypeptide exit tunnel
CLM74_RS04085	COG0089	rRNA binding
CLM74_RS04090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLM74_RS04095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLM74_RS04100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLM74_RS04105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLM74_RS04110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLM74_RS04115	COG0255	Belongs to the universal ribosomal protein uL29 family
CLM74_RS04120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLM74_RS04125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLM74_RS04130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLM74_RS04135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLM74_RS04140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLM74_RS04145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLM74_RS04150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLM74_RS04155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLM74_RS04160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLM74_RS04165	COG1841	ribosomal large subunit assembly
CLM74_RS04175	COG0201	protein transport
CLM74_RS04180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLM74_RS04185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLM74_RS04190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLM74_RS04195	COG0202	RNA polymerase activity
CLM74_RS04200	COG0203	ribosomal protein L17
CLM74_RS04215	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CLM74_RS04225	COG0154	amidase activity
CLM74_RS04240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLM74_RS04245	COG0039	L-malate dehydrogenase activity
CLM74_RS04265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLM74_RS04280	COG0625	glutathione transferase activity
CLM74_RS04290	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLM74_RS04290	COG1902	pentaerythritol trinitrate reductase activity
CLM74_RS04295	COG2364	Membrane
CLM74_RS04300	COG0604	alcohol dehydrogenase
CLM74_RS04315	COG1187	pseudouridine synthase activity
CLM74_RS04335	COG1063	alcohol dehydrogenase
CLM74_RS04345	COG0406	alpha-ribazole phosphatase activity
CLM74_RS04350	COG0285	dihydrofolate synthase activity
CLM74_RS04370	COG2833	Protein of unknown function (DUF455)
CLM74_RS04380	COG3291	Pkd domain containing protein
CLM74_RS04385	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLM74_RS04390	COG0671	phosphoesterase, PA-phosphatase related
CLM74_RS04395	COG0438	transferase activity, transferring glycosyl groups
CLM74_RS04400	COG4206	TonB-dependent receptor
CLM74_RS04405	COG0248	Ppx GppA phosphatase
CLM74_RS04410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLM74_RS04425	COG4783	chaperone-mediated protein folding
CLM74_RS04440	COG0473	3-isopropylmalate dehydrogenase activity
CLM74_RS04510	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLM74_RS04520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLM74_RS04555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLM74_RS04560	COG1388	LysM domain
CLM74_RS04560	COG3942	CHAP domain
CLM74_RS04565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM74_RS04580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLM74_RS04585	COG0631	protein serine/threonine phosphatase activity
CLM74_RS04600	COG0859	PFAM glycosyl transferase family 9
CLM74_RS04605	COG3642	lipopolysaccharide core region biosynthetic process
CLM74_RS04610	COG1234	tRNA 3'-trailer cleavage
CLM74_RS04625	COG2076	Multidrug Resistance protein
CLM74_RS04650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLM74_RS04655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLM74_RS04665	COG0537	adenosine 5'-monophosphoramidase activity
CLM74_RS04685	COG0714	Associated with various cellular activities
CLM74_RS04700	COG1399	metal-binding, possibly nucleic acid-binding protein
CLM74_RS04705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLM74_RS04710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM74_RS04720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLM74_RS04735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLM74_RS04740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLM74_RS04745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLM74_RS04750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLM74_RS04855	COG1388	LysM domain
CLM74_RS04910	COG4774	siderophore transport
CLM74_RS04940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM74_RS04945	COG0697	spore germination
CLM74_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS04955	COG0583	DNA-binding transcription factor activity
CLM74_RS04960	COG0583	DNA-binding transcription factor activity
CLM74_RS04965	COG0477	Major facilitator Superfamily
CLM74_RS04975	COG2205	protein histidine kinase activity
CLM74_RS05025	COG0583	DNA-binding transcription factor activity
CLM74_RS05050	COG0667	Aldo Keto reductase
CLM74_RS05070	COG2818	Glycosylase
CLM74_RS05075	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CLM74_RS05080	COG1678	Uncharacterized ACR, COG1678
CLM74_RS05085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLM74_RS05090	COG0540	Belongs to the ATCase OTCase family
CLM74_RS05110	COG2239	Acts as a magnesium transporter
CLM74_RS05115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLM74_RS05130	COG1660	Displays ATPase and GTPase activities
CLM74_RS05135	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLM74_RS05140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLM74_RS05145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CLM74_RS05155	COG1137	ATPase activity
CLM74_RS05170	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CLM74_RS05185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLM74_RS05205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLM74_RS05225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLM74_RS05235	COG0628	permease
CLM74_RS05245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLM74_RS05255	COG2261	transglycosylase associated protein
CLM74_RS05285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CLM74_RS05290	COG1477	protein flavinylation
CLM74_RS05310	COG4771	TonB-dependent receptor
CLM74_RS05320	COG3128	pkhd-type hydroxylase
CLM74_RS05330	COG4774	siderophore transport
CLM74_RS05340	COG2146	nitrite reductase [NAD(P)H] activity
CLM74_RS05365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLM74_RS05370	COG0719	Fe-S assembly protein
CLM74_RS05375	COG0396	ATPase activity
CLM74_RS05380	COG0719	Fe-S assembly protein
CLM74_RS05385	COG1959	2 iron, 2 sulfur cluster binding
CLM74_RS05395	COG0693	protein deglycase activity
CLM74_RS05420	COG1764	response to oxidative stress
CLM74_RS05425	COG0384	phenazine biosynthesis protein PhzF
CLM74_RS05430	COG0384	phenazine biosynthesis protein PhzF
CLM74_RS05435	COG0527	aspartate kinase activity
CLM74_RS05445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLM74_RS05460	COG0142	geranyltranstransferase activity
CLM74_RS05465	COG0366	Alpha amylase catalytic
CLM74_RS05475	COG1082	Xylose isomerase domain protein TIM barrel
CLM74_RS05485	COG2190	(PTS) system
CLM74_RS05485	COG2211	Major facilitator Superfamily
CLM74_RS05490	COG0366	Alpha amylase catalytic
CLM74_RS05490	COG1874	Beta-galactosidase
CLM74_RS05515	COG1131	(ABC) transporter
CLM74_RS05525	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CLM74_RS05530	COG4191	Histidine kinase
CLM74_RS05530	COG0784	Response regulator, receiver
CLM74_RS05540	COG0629	single-stranded DNA binding
CLM74_RS05565	COG2010	Cytochrome c
CLM74_RS05575	COG0673	inositol 2-dehydrogenase activity
CLM74_RS05580	COG2211	Major facilitator Superfamily
CLM74_RS05590	COG1609	Transcriptional regulator
CLM74_RS05595	COG2259	Doxx family
CLM74_RS05600	COG0798	PFAM Bile acid sodium symporter
CLM74_RS05605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLM74_RS05615	COG0431	NADPH-dependent FMN reductase
CLM74_RS05650	COG0640	Transcriptional regulator
CLM74_RS05665	COG3655	Transcriptional regulator
CLM74_RS05670	COG1253	flavin adenine dinucleotide binding
CLM74_RS05675	COG1408	metallophosphoesterase
CLM74_RS05705	COG2259	Doxx family
CLM74_RS05730	COG0477	Major facilitator Superfamily
CLM74_RS05745	COG1802	Transcriptional regulator
CLM74_RS05780	COG3052	prosthetic group binding
CLM74_RS05795	COG0579	oxidoreductase
CLM74_RS05835	COG3104	oligopeptide transport
CLM74_RS05850	COG1297	OPT oligopeptide transporter protein
CLM74_RS05855	COG1506	peptidase
CLM74_RS05855	COG0823	Involved in the tonB-independent uptake of proteins
CLM74_RS05870	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLM74_RS05875	COG2894	cell division
CLM74_RS05890	COG4585	Histidine kinase
CLM74_RS05895	COG2197	response regulator
CLM74_RS05915	COG1073	alpha beta
CLM74_RS05935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CLM74_RS05945	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CLM74_RS05955	COG1595	DNA-templated transcription, initiation
CLM74_RS05965	COG1946	Acyl-CoA thioesterase
CLM74_RS05985	COG0824	Thioesterase
CLM74_RS05990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLM74_RS05995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLM74_RS06000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLM74_RS06005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLM74_RS06010	COG0268	Binds directly to 16S ribosomal RNA
CLM74_RS06015	COG0728	peptidoglycan biosynthetic process
CLM74_RS06020	COG0196	riboflavin kinase activity
CLM74_RS06025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLM74_RS06035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLM74_RS06065	COG4206	TonB-dependent receptor
CLM74_RS06085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLM74_RS06185	COG4245	von Willebrand factor, type A
CLM74_RS06220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CLM74_RS06225	COG1845	cytochrome c oxidase, subunit III
CLM74_RS06230	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CLM74_RS06245	COG0326	Molecular chaperone. Has ATPase activity
CLM74_RS06265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLM74_RS06285	COG0228	four-way junction DNA binding
CLM74_RS06290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLM74_RS06295	COG0336	Belongs to the RNA methyltransferase TrmD family
CLM74_RS06300	COG0335	large ribosomal subunit rRNA binding
CLM74_RS06320	COG0534	Mate efflux family protein
CLM74_RS06335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CLM74_RS06390	COG0641	radical SAM
CLM74_RS06460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLM74_RS06510	COG3621	Patatin-like phospholipase
CLM74_RS06530	COG0210	DNA helicase
CLM74_RS06565	COG0583	DNA-binding transcription factor activity
CLM74_RS06585	COG1012	belongs to the aldehyde dehydrogenase family
CLM74_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS06610	COG1252	NADH dehydrogenase
CLM74_RS06630	COG1127	ABC transporter
CLM74_RS06635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLM74_RS06655	COG0745	RESPONSE REGULATOR receiver
CLM74_RS06660	COG5000	phosphorelay sensor kinase activity
CLM74_RS06660	COG5002	protein histidine kinase activity
CLM74_RS06715	COG2831	hemolysin activation secretion protein
CLM74_RS06720	COG3210	domain, Protein
CLM74_RS06755	COG0840	transmembrane signaling receptor activity
CLM74_RS06780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM74_RS06800	COG0024	Methionine aminopeptidase
CLM74_RS06825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CLM74_RS06850	COG1647	Serine aminopeptidase, S33
CLM74_RS06875	COG2814	Major facilitator Superfamily
CLM74_RS06880	COG3706	GGDEF domain
CLM74_RS06895	COG1515	deoxyribonuclease V activity
CLM74_RS06900	COG0588	phosphoglycerate mutase activity
CLM74_RS06905	COG3590	peptidase
CLM74_RS06925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLM74_RS06935	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CLM74_RS06940	COG0745	RESPONSE REGULATOR receiver
CLM74_RS06945	COG2205	protein histidine kinase activity
CLM74_RS06950	COG4452	Inner membrane protein CreD
CLM74_RS06965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLM74_RS06970	COG0735	belongs to the Fur family
CLM74_RS07055	COG5001	Diguanylate cyclase
CLM74_RS07055	COG5002	protein histidine kinase activity
CLM74_RS07065	COG1187	pseudouridine synthase activity
CLM74_RS07075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLM74_RS07105	COG1132	(ABC) transporter
CLM74_RS07170	COG1981	membrane
CLM74_RS07175	COG0825	malonyl-CoA metabolic process
CLM74_RS07200	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLM74_RS07205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLM74_RS07210	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLM74_RS07220	COG0750	zinc metalloprotease
CLM74_RS07225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLM74_RS07230	COG0575	Belongs to the CDS family
CLM74_RS07235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLM74_RS07240	COG0233	cytoplasmic translational termination
CLM74_RS07245	COG0528	UMP kinase activity
CLM74_RS07255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLM74_RS07260	COG0052	Belongs to the universal ribosomal protein uS2 family
CLM74_RS07280	COG3188	usher protein
CLM74_RS07300	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CLM74_RS07310	COG1393	Belongs to the ArsC family
CLM74_RS07315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLM74_RS07325	COG0367	asparagine synthase
CLM74_RS07330	COG0475	glutathione-regulated potassium exporter activity
CLM74_RS07335	COG2366	antibiotic biosynthetic process
CLM74_RS07365	COG1566	PFAM secretion protein HlyD family protein
CLM74_RS07370	COG2814	Major facilitator Superfamily
CLM74_RS07380	COG0583	DNA-binding transcription factor activity
CLM74_RS07400	COG0557	exoribonuclease II activity
CLM74_RS07410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLM74_RS07415	COG1538	Outer membrane efflux protein
CLM74_RS07420	COG1136	(ABC) transporter
CLM74_RS07420	COG0577	efflux transmembrane transporter activity
CLM74_RS07425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM74_RS07445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLM74_RS07450	COG2259	Doxx family
CLM74_RS07460	COG3220	belongs to the UPF0276 family
CLM74_RS07470	COG0704	Plays a role in the regulation of phosphate uptake
CLM74_RS07480	COG0581	inorganic phosphate transmembrane transporter activity
CLM74_RS07485	COG0573	inorganic phosphate transmembrane transporter activity
CLM74_RS07490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLM74_RS07495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLM74_RS07510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLM74_RS07520	COG1024	Enoyl-CoA hydratase
CLM74_RS07550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLM74_RS07550	COG0116	Belongs to the methyltransferase superfamily
CLM74_RS07575	COG2733	membrane
CLM74_RS07585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLM74_RS07590	COG1012	belongs to the aldehyde dehydrogenase family
CLM74_RS07600	COG0477	Major facilitator Superfamily
CLM74_RS07605	COG2703	oxygen carrier activity
CLM74_RS07630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM74_RS07635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLM74_RS07640	COG0174	glutamine synthetase
CLM74_RS07650	COG2072	flavoprotein involved in K transport
CLM74_RS07655	COG3842	ATPase activity
CLM74_RS07660	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLM74_RS07665	COG1177	transmembrane transport
CLM74_RS07670	COG1012	belongs to the aldehyde dehydrogenase family
CLM74_RS07685	COG4535	Mg2 and Co2 transporter CorC
CLM74_RS07705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLM74_RS07710	COG1702	phosphate starvation-inducible protein PhoH
CLM74_RS07720	COG1131	(ABC) transporter
CLM74_RS07725	COG0842	Transport permease protein
CLM74_RS07730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLM74_RS07745	COG0741	lytic transglycosylase activity
CLM74_RS07750	COG0723	plastoquinol--plastocyanin reductase activity
CLM74_RS07755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CLM74_RS07760	COG2857	Cytochrome c1
CLM74_RS07765	COG0625	glutathione transferase activity
CLM74_RS07770	COG2969	positive regulation of protein catabolic process
CLM74_RS07805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLM74_RS07810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CLM74_RS07815	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS07825	COG1611	Belongs to the LOG family
CLM74_RS07870	COG0556	nucleotide-excision repair
CLM74_RS07915	COG3713	MltA-interacting MipA family protein
CLM74_RS07925	COG2205	protein histidine kinase activity
CLM74_RS07930	COG0658	competence protein
CLM74_RS07930	COG2333	competence protein COMEC
CLM74_RS07935	COG0811	peptide transport
CLM74_RS07950	COG1663	tetraacyldisaccharide 4'-kinase activity
CLM74_RS07955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CLM74_RS07960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLM74_RS07970	COG0322	excinuclease ABC activity
CLM74_RS08010	COG0577	efflux transmembrane transporter activity
CLM74_RS08010	COG1136	(ABC) transporter
CLM74_RS08050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLM74_RS08070	COG1917	Cupin 2, conserved barrel domain protein
CLM74_RS08070	COG4977	sequence-specific DNA binding
CLM74_RS08075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLM74_RS08095	COG0348	domain, Protein
CLM74_RS08110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLM74_RS08180	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CLM74_RS08185	COG0069	glutamate synthase activity
CLM74_RS08210	COG1054	Belongs to the UPF0176 family
CLM74_RS08215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLM74_RS08230	COG1253	flavin adenine dinucleotide binding
CLM74_RS08250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLM74_RS08265	COG0504	CTP synthase activity
CLM74_RS08270	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CLM74_RS08285	COG0148	phosphopyruvate hydratase activity
CLM74_RS08290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CLM74_RS08295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLM74_RS08300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLM74_RS08310	COG2840	Smr protein MutS2
CLM74_RS08315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLM74_RS08320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLM74_RS08340	COG1534	Rna-binding protein
CLM74_RS08345	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CLM74_RS08350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLM74_RS08365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLM74_RS08370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLM74_RS08375	COG1923	regulation of RNA biosynthetic process
CLM74_RS08380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLM74_RS08385	COG1546	Belongs to the CinA family
CLM74_RS08390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLM74_RS08395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLM74_RS08400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLM74_RS08405	COG2137	regulation of response to DNA damage stimulus
CLM74_RS08410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLM74_RS08415	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLM74_RS08425	COG1201	RNA secondary structure unwinding
CLM74_RS08435	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CLM74_RS08440	COG1595	DNA-templated transcription, initiation
CLM74_RS08455	COG3540	Alkaline phosphatase
CLM74_RS08470	COG3258	Cytochrome c
CLM74_RS08485	COG2223	nitrite transmembrane transporter activity
CLM74_RS08500	COG1741	Belongs to the pirin family
CLM74_RS08505	COG0583	DNA-binding transcription factor activity
CLM74_RS08530	COG0351	phosphomethylpyrimidine kinase
CLM74_RS08530	COG0352	thiamine-phosphate diphosphorylase activity
CLM74_RS08545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLM74_RS08550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLM74_RS08560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLM74_RS08570	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CLM74_RS08575	COG0477	Major facilitator Superfamily
CLM74_RS08585	COG0617	tRNA 3'-terminal CCA addition
CLM74_RS08595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLM74_RS08600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLM74_RS08610	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLM74_RS08615	COG0166	Belongs to the GPI family
CLM74_RS08620	COG0166	Belongs to the GPI family
CLM74_RS08625	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CLM74_RS08635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLM74_RS08640	COG0671	phosphoesterase, PA-phosphatase related
CLM74_RS08650	COG0800	Aldolase
CLM74_RS08655	COG0129	dihydroxy-acid dehydratase activity
CLM74_RS08660	COG0363	glucosamine-6-phosphate deaminase activity
CLM74_RS08665	COG0837	glucose binding
CLM74_RS08670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CLM74_RS08690	COG2009	succinate dehydrogenase
CLM74_RS08695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CLM74_RS08720	COG4591	ABC-type transport system involved in lipoprotein release permease component
CLM74_RS08735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CLM74_RS08745	COG0552	protein localization to endoplasmic reticulum
CLM74_RS08770	COG0742	ribosomal rna small subunit methyltransferase
CLM74_RS08775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLM74_RS08785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLM74_RS08790	COG0405	Gamma-glutamyltransferase
CLM74_RS08795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM74_RS08805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLM74_RS08835	COG0415	Belongs to the DNA photolyase family
CLM74_RS08840	COG2885	chlorophyll binding
CLM74_RS08845	COG0583	DNA-binding transcription factor activity
CLM74_RS08960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLM74_RS08970	COG2914	Belongs to the UPF0125 (RnfH) family
CLM74_RS08975	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLM74_RS08980	COG0735	belongs to the Fur family
CLM74_RS08990	COG0583	DNA-binding transcription factor activity
CLM74_RS08995	COG0497	DNA recombination
CLM74_RS09000	COG1420	regulation of RNA biosynthetic process
CLM74_RS09005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLM74_RS09010	COG0443	Heat shock 70 kDa protein
CLM74_RS09015	COG0484	heat shock protein binding
CLM74_RS09020	COG2207	Transcriptional regulator
CLM74_RS09025	COG2223	nitrite transmembrane transporter activity
CLM74_RS09030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CLM74_RS09035	COG0287	Prephenate dehydrogenase
CLM74_RS09035	COG1605	Chorismate mutase
CLM74_RS09045	COG1132	(ABC) transporter
CLM74_RS09065	COG5001	Diguanylate cyclase
CLM74_RS09075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLM74_RS09080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLM74_RS09085	COG0343	queuine tRNA-ribosyltransferase activity
CLM74_RS09090	COG1862	Preprotein translocase
CLM74_RS09100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLM74_RS09105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CLM74_RS09115	COG2081	HI0933 family
CLM74_RS09125	COG0564	pseudouridine synthase activity
CLM74_RS09150	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CLM74_RS09155	COG3420	alginic acid biosynthetic process
CLM74_RS09165	COG0710	3-dehydroquinate dehydratase activity
CLM74_RS09180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CLM74_RS09190	COG3485	protocatechuate 3,4-dioxygenase
CLM74_RS09195	COG3485	protocatechuate 3,4-dioxygenase
CLM74_RS09205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLM74_RS09210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLM74_RS09215	COG1414	Transcriptional regulator
CLM74_RS09225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLM74_RS09230	COG0513	Belongs to the DEAD box helicase family
CLM74_RS09245	COG0583	DNA-binding transcription factor activity
CLM74_RS09250	COG0488	(ABC) transporter
CLM74_RS09275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM74_RS09290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLM74_RS09295	COG2957	Belongs to the agmatine deiminase family
CLM74_RS09305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLM74_RS09310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLM74_RS09320	COG0776	regulation of translation
CLM74_RS09330	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CLM74_RS09335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLM74_RS09345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLM74_RS09350	COG0183	Belongs to the thiolase family
CLM74_RS09355	COG1024	Enoyl-CoA hydratase
CLM74_RS09355	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLM74_RS09365	COG0105	UTP biosynthetic process
CLM74_RS09370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLM74_RS09380	COG1426	Protein conserved in bacteria
CLM74_RS09385	COG2976	Protein conserved in bacteria
CLM74_RS09390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLM74_RS09395	COG1160	GTP binding
CLM74_RS09405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLM74_RS09410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CLM74_RS09410	COG0475	glutathione-regulated potassium exporter activity
CLM74_RS09430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLM74_RS09430	COG0519	Catalyzes the synthesis of GMP from XMP
CLM74_RS09435	COG0583	DNA-binding transcription factor activity
CLM74_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS09505	COG0583	DNA-binding transcription factor activity
CLM74_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS09560	COG0640	Transcriptional regulator
CLM74_RS09580	COG4716	Myosin-crossreactive antigen
CLM74_RS09585	COG0300	oxidoreductase activity
CLM74_RS09590	COG2207	Transcriptional regulator
CLM74_RS09620	COG0431	NADPH-dependent FMN reductase
CLM74_RS09635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLM74_RS09640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLM74_RS09645	COG1473	amidohydrolase
CLM74_RS09655	COG1126	abc transporter atp-binding protein
CLM74_RS09660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLM74_RS09725	COG1309	transcriptional regulator
CLM74_RS09745	COG0697	spore germination
CLM74_RS09750	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLM74_RS09755	COG0167	dihydroorotate dehydrogenase activity
CLM74_RS09770	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS09775	COG1012	belongs to the aldehyde dehydrogenase family
CLM74_RS09825	COG4191	Histidine kinase
CLM74_RS09825	COG0784	Response regulator, receiver
CLM74_RS09830	COG2205	protein histidine kinase activity
CLM74_RS09830	COG3437	response regulator, receiver
CLM74_RS09830	COG3850	Histidine kinase
CLM74_RS09830	COG4999	Histidine kinase
CLM74_RS09835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLM74_RS09855	COG0640	Transcriptional regulator
CLM74_RS09900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CLM74_RS09905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM74_RS09910	COG0124	histidyl-tRNA synthetase
CLM74_RS09925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLM74_RS09930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLM74_RS09935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLM74_RS09940	COG0131	Imidazoleglycerol-phosphate dehydratase
CLM74_RS09940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLM74_RS09945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLM74_RS09950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLM74_RS09955	COG0107	imidazoleglycerol-phosphate synthase activity
CLM74_RS09960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLM74_RS09960	COG0140	phosphoribosyl-ATP diphosphatase activity
CLM74_RS09975	COG0837	glucose binding
CLM74_RS09980	COG1446	asparaginase
CLM74_RS09985	COG3142	Participates in the control of copper homeostasis
CLM74_RS10000	COG0789	Transcriptional regulator
CLM74_RS10015	COG3537	Alpha-1,2-mannosidase
CLM74_RS10020	COG1609	Transcriptional regulator
CLM74_RS10030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLM74_RS10045	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CLM74_RS10050	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CLM74_RS10055	COG0235	Class ii aldolase
CLM74_RS10060	COG0531	amino acid
CLM74_RS10065	COG0531	amino acid
CLM74_RS10075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLM74_RS10080	COG0277	FAD linked oxidase domain protein
CLM74_RS10095	COG5002	protein histidine kinase activity
CLM74_RS10100	COG0745	RESPONSE REGULATOR receiver
CLM74_RS10105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM74_RS10110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM74_RS10130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLM74_RS10155	COG1024	Enoyl-CoA hydratase
CLM74_RS10165	COG1918	ferrous iron import across plasma membrane
CLM74_RS10165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLM74_RS10175	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLM74_RS10180	COG0789	Transcriptional regulator
CLM74_RS10190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLM74_RS10195	COG0505	Belongs to the CarA family
CLM74_RS10205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLM74_RS10210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLM74_RS10230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLM74_RS10250	COG3279	Response regulator of the LytR AlgR family
CLM74_RS10265	COG1012	belongs to the aldehyde dehydrogenase family
CLM74_RS10285	COG0784	Response regulator, receiver
CLM74_RS10285	COG2198	Histidine kinase
CLM74_RS10285	COG2205	protein histidine kinase activity
CLM74_RS10290	COG1024	Enoyl-CoA hydratase
CLM74_RS10295	COG0318	PFAM AMP-dependent synthetase and ligase
CLM74_RS10300	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CLM74_RS10305	COG1012	belongs to the aldehyde dehydrogenase family
CLM74_RS10310	COG1309	transcriptional regulator
CLM74_RS10360	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CLM74_RS10370	COG0840	transmembrane signaling receptor activity
CLM74_RS10370	COG0840	transmembrane signaling receptor activity
CLM74_RS10375	COG0840	transmembrane signaling receptor activity
CLM74_RS10385	COG0835	chemotaxis
CLM74_RS10390	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CLM74_RS10395	COG0840	transmembrane signaling receptor activity
CLM74_RS10405	COG0745	RESPONSE REGULATOR receiver
CLM74_RS10415	COG0835	chemotaxis
CLM74_RS10425	COG1360	Flagellar Motor Protein
CLM74_RS10430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLM74_RS10435	COG2198	Histidine kinase
CLM74_RS10435	COG0643	Histidine kinase
CLM74_RS10435	COG0784	Response regulator, receiver
CLM74_RS10440	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CLM74_RS10465	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLM74_RS10470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLM74_RS10485	COG1987	bacterial-type flagellum assembly
CLM74_RS10495	COG3190	flagellar
CLM74_RS10545	COG1677	Flagellar hook-basal body complex protein FliE
CLM74_RS10570	COG2197	response regulator
CLM74_RS10590	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLM74_RS10595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLM74_RS10600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLM74_RS10630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CLM74_RS10640	COG4787	bacterial-type flagellum-dependent cell motility
CLM74_RS10650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLM74_RS10655	COG1558	bacterial-type flagellum-dependent cell motility
CLM74_RS10660	COG1815	bacterial-type flagellum-dependent cell motility
CLM74_RS10665	COG0835	chemotaxis
CLM74_RS10665	COG0784	Response regulator, receiver
CLM74_RS10685	COG5002	protein histidine kinase activity
CLM74_RS10725	COG2915	High frequency lysogenization protein hflD homolog
CLM74_RS10730	COG0482	sulfurtransferase activity
CLM74_RS10745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CLM74_RS10755	COG0542	response to heat
CLM74_RS10790	COG0492	ferredoxin-NADP+ reductase activity
CLM74_RS10795	COG1674	ftsk spoiiie
CLM74_RS10810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLM74_RS10825	COG2819	hydrolase of the alpha beta superfamily
CLM74_RS10835	COG4558	Periplasmic binding protein
CLM74_RS10840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLM74_RS10845	COG1120	ATPase activity
CLM74_RS10855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLM74_RS10870	COG0784	Response regulator, receiver
CLM74_RS10870	COG5002	protein histidine kinase activity
CLM74_RS10925	COG2200	EAL domain
CLM74_RS10940	COG3634	alkyl hydroperoxide reductase activity
CLM74_RS10990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM74_RS10990	COG0723	plastoquinol--plastocyanin reductase activity
CLM74_RS10995	COG3546	catalase activity
CLM74_RS11000	COG3685	Protein conserved in bacteria
CLM74_RS11015	COG1063	alcohol dehydrogenase
CLM74_RS11030	COG0366	Alpha amylase catalytic
CLM74_RS11045	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS11080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLM74_RS11085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLM74_RS11110	COG3685	Protein conserved in bacteria
CLM74_RS11200	COG0667	Aldo Keto reductase
CLM74_RS11220	COG1073	alpha beta
CLM74_RS11260	COG2207	Transcriptional regulator
CLM74_RS11265	COG3459	Glycosyltransferase 36 associated
CLM74_RS11290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLM74_RS11295	COG1136	(ABC) transporter
CLM74_RS11295	COG0577	efflux transmembrane transporter activity
CLM74_RS11300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM74_RS11305	COG0745	RESPONSE REGULATOR receiver
CLM74_RS11310	COG2205	protein histidine kinase activity
CLM74_RS11330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLM74_RS11340	COG0583	DNA-binding transcription factor activity
CLM74_RS11345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLM74_RS11350	COG0583	DNA-binding transcription factor activity
CLM74_RS11355	COG0431	NADPH-dependent FMN reductase
CLM74_RS11375	COG2610	gluconate transmembrane transporter activity
CLM74_RS11385	COG0596	Alpha beta hydrolase
CLM74_RS11395	COG0642	Histidine kinase
CLM74_RS11410	COG0318	PFAM AMP-dependent synthetase and ligase
CLM74_RS11435	COG1902	pentaerythritol trinitrate reductase activity
CLM74_RS11440	COG4221	oxidoreductase activity
CLM74_RS11445	COG0604	alcohol dehydrogenase
CLM74_RS11505	COG3685	Protein conserved in bacteria
CLM74_RS11550	COG0346	lactoylglutathione lyase activity
CLM74_RS11575	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CLM74_RS11610	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CLM74_RS11620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLM74_RS11675	COG2080	2 iron, 2 sulfur cluster binding
CLM74_RS11680	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CLM74_RS11685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLM74_RS11695	COG2068	MobA-Related Protein
CLM74_RS11715	COG2199	diguanylate cyclase activity
CLM74_RS11720	COG0708	Exodeoxyribonuclease III
CLM74_RS11725	COG3214	Protein conserved in bacteria
CLM74_RS11780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLM74_RS11785	COG1285	pathogenesis
CLM74_RS11790	COG4191	Histidine kinase
CLM74_RS11795	COG4566	intracellular signal transduction
CLM74_RS11845	COG0243	molybdopterin cofactor binding
CLM74_RS11860	COG0477	Major facilitator Superfamily
CLM74_RS11885	COG1136	(ABC) transporter
CLM74_RS11900	COG4771	TonB-dependent receptor
CLM74_RS11910	COG0583	DNA-binding transcription factor activity
CLM74_RS11915	COG0656	L-ascorbic acid biosynthetic process
CLM74_RS11940	COG0583	DNA-binding transcription factor activity
CLM74_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS11950	COG3537	Alpha-1,2-mannosidase
CLM74_RS11965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM74_RS11975	COG0477	Major facilitator Superfamily
CLM74_RS12020	COG0583	DNA-binding transcription factor activity
CLM74_RS12030	COG1335	isochorismatase
CLM74_RS12035	COG1335	isochorismatase
CLM74_RS12065	COG0811	peptide transport
CLM74_RS12095	COG4795	General secretion pathway protein
CLM74_RS12190	COG0840	transmembrane signaling receptor activity
CLM74_RS12195	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CLM74_RS12205	COG4149	molybdate abc transporter
CLM74_RS12215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM74_RS12230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLM74_RS12235	COG2181	nitrate reductase activity
CLM74_RS12240	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CLM74_RS12245	COG1140	nitrate reductase beta subunit
CLM74_RS12250	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CLM74_RS12255	COG2223	nitrite transmembrane transporter activity
CLM74_RS12265	COG0746	molybdenum cofactor guanylyltransferase activity
CLM74_RS12270	COG0314	molybdopterin synthase activity
CLM74_RS12280	COG0303	'Molybdopterin
CLM74_RS12285	COG0315	cyclic pyranopterin monophosphate synthase activity
CLM74_RS12285	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLM74_RS12290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLM74_RS12340	COG2207	Transcriptional regulator
CLM74_RS12355	COG1566	PFAM secretion protein HlyD family protein
CLM74_RS12370	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CLM74_RS12425	COG2885	chlorophyll binding
CLM74_RS12460	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS12465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLM74_RS12465	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CLM74_RS12475	COG3433	isochorismatase activity
CLM74_RS12475	COG1535	isochorismatase
CLM74_RS12480	COG1021	2,3-dihydroxybenzoate-AMP ligase
CLM74_RS12495	COG2409	Drug exporters of the RND superfamily
CLM74_RS12500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CLM74_RS12560	COG1914	H( )-stimulated, divalent metal cation uptake system
CLM74_RS12575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLM74_RS12580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLM74_RS12585	COG3321	synthase
CLM74_RS12585	COG0604	alcohol dehydrogenase
CLM74_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS12590	COG4206	TonB-dependent receptor
CLM74_RS12595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLM74_RS12630	COG0583	DNA-binding transcription factor activity
CLM74_RS12640	COG4772	TonB-dependent receptor
CLM74_RS12670	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CLM74_RS12670	COG2885	chlorophyll binding
CLM74_RS12675	COG5295	Hep Hag repeat protein
CLM74_RS12705	COG4964	Belongs to the GSP D family
CLM74_RS12760	COG2814	Major facilitator Superfamily
CLM74_RS12770	COG1228	amidohydrolase
CLM74_RS12780	COG1335	isochorismatase
CLM74_RS12795	COG3850	Histidine kinase
CLM74_RS12800	COG2197	response regulator
CLM74_RS12820	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLM74_RS12830	COG0583	DNA-binding transcription factor activity
CLM74_RS12840	COG3161	chorismate lyase activity
CLM74_RS12880	COG0277	FAD linked oxidase domain protein
CLM74_RS12885	COG1304	FMN binding
CLM74_RS12890	COG2186	Transcriptional regulator
CLM74_RS12900	COG1285	pathogenesis
CLM74_RS12930	COG2814	Major facilitator Superfamily
CLM74_RS12985	COG0587	DNA-directed DNA polymerase activity
CLM74_RS13000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLM74_RS13025	COG1595	DNA-templated transcription, initiation
CLM74_RS13035	COG1629	transport
CLM74_RS13035	COG4206	TonB-dependent receptor
CLM74_RS13065	COG0531	amino acid
CLM74_RS13080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM74_RS13090	COG0789	Transcriptional regulator
CLM74_RS13170	COG5002	protein histidine kinase activity
CLM74_RS13170	COG5001	Diguanylate cyclase
CLM74_RS13170	COG3447	MASE1 domain protein
CLM74_RS13175	COG2183	response to ionizing radiation
CLM74_RS13205	COG3243	poly(R)-hydroxyalkanoic acid synthase
CLM74_RS13235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CLM74_RS13245	COG0668	transmembrane transport
CLM74_RS13250	COG1902	pentaerythritol trinitrate reductase activity
CLM74_RS13335	COG3702	type iv secretory pathway
CLM74_RS13355	COG2948	multi-organism process
CLM74_RS13365	COG3736	Type IV secretory pathway, component VirB8
CLM74_RS13375	COG3505	Type IV secretory pathway VirD4
CLM74_RS13390	COG2814	Major facilitator Superfamily
CLM74_RS13425	COG4774	siderophore transport
CLM74_RS13435	COG0745	RESPONSE REGULATOR receiver
CLM74_RS13450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM74_RS13455	COG1136	(ABC) transporter
CLM74_RS13455	COG0577	efflux transmembrane transporter activity
CLM74_RS13500	COG0582	viral genome integration into host DNA
CLM74_RS13525	COG0583	DNA-binding transcription factor activity
CLM74_RS13530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CLM74_RS13540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLM74_RS13555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLM74_RS13560	COG1605	Chorismate mutase
CLM74_RS13560	COG0077	Prephenate dehydratase
CLM74_RS13565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLM74_RS13600	COG1228	amidohydrolase
CLM74_RS13615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CLM74_RS13745	COG4993	Dehydrogenase
CLM74_RS13755	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLM74_RS13765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CLM74_RS13775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLM74_RS13780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLM74_RS13795	COG0359	binds to the 23S rRNA
CLM74_RS13800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLM74_RS13805	COG0360	Binds together with S18 to 16S ribosomal RNA
CLM74_RS13820	COG0316	Belongs to the HesB IscA family
CLM74_RS13825	COG0017	Asparaginyl-tRNA synthetase
CLM74_RS13840	COG2808	Putative FMN-binding domain
CLM74_RS13845	COG0288	reversible hydration of carbon dioxide
CLM74_RS13855	COG3844	kynureninase activity
CLM74_RS13860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLM74_RS13865	COG2925	Exonuclease
CLM74_RS13890	COG2902	Dehydrogenase
CLM74_RS13900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM74_RS13905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM74_RS13915	COG1960	acyl-CoA dehydrogenase activity
CLM74_RS13930	COG1410	methionine synthase
CLM74_RS13930	COG0646	methionine synthase
CLM74_RS13940	COG2900	Belongs to the SlyX family
CLM74_RS13955	COG0386	Belongs to the glutathione peroxidase family
CLM74_RS13965	COG1725	Transcriptional regulator
CLM74_RS13970	COG1131	(ABC) transporter
CLM74_RS14005	COG2850	peptidyl-arginine hydroxylation
CLM74_RS14015	COG0567	Dehydrogenase, E1 component
CLM74_RS14045	COG0305	Participates in initiation and elongation during chromosome replication
CLM74_RS14065	COG0625	glutathione transferase activity
CLM74_RS14085	COG0084	hydrolase, TatD family'
CLM74_RS14090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLM74_RS14110	COG2839	Protein conserved in bacteria
CLM74_RS14145	COG1595	DNA-templated transcription, initiation
CLM74_RS14150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLM74_RS14165	COG0386	Belongs to the glutathione peroxidase family
CLM74_RS14170	COG0339	signal peptide processing
CLM74_RS14175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLM74_RS14190	COG0705	Rhomboid family
CLM74_RS14195	COG3104	oligopeptide transport
CLM74_RS14205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLM74_RS14225	COG0316	Belongs to the HesB IscA family
CLM74_RS14225	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CLM74_RS14230	COG2154	pterin-4-alpha-carbinolamine dehydratase
CLM74_RS14240	COG0428	transporter
CLM74_RS14250	COG1530	ribonuclease E activity
CLM74_RS14265	COG0395	ABC-type sugar transport system, permease component
CLM74_RS14295	COG0271	Belongs to the BolA IbaG family
CLM74_RS14300	COG2350	Protein conserved in bacteria
CLM74_RS14305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLM74_RS14310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLM74_RS14315	COG1187	pseudouridine synthase activity
CLM74_RS14330	COG2814	Major facilitator Superfamily
CLM74_RS14350	COG0436	Aminotransferase
CLM74_RS14375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CLM74_RS14390	COG4235	cytochrome complex assembly
CLM74_RS14390	COG3088	subunit of a heme lyase
CLM74_RS14400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLM74_RS14410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CLM74_RS14415	COG4988	ABC transporter
CLM74_RS14420	COG1271	oxidase subunit
CLM74_RS14425	COG1294	oxidase, subunit
CLM74_RS14455	COG0726	polysaccharide deacetylase
CLM74_RS14455	COG1649	PFAM Uncharacterised BCR, COG1649
CLM74_RS14460	COG1215	transferase activity, transferring glycosyl groups
CLM74_RS14470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLM74_RS14485	COG0165	Argininosuccinate lyase
CLM74_RS14490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLM74_RS14500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLM74_RS14505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLM74_RS14510	COG0137	argininosuccinate synthase activity
CLM74_RS14515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLM74_RS14530	COG2166	iron-sulfur cluster assembly
CLM74_RS14550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLM74_RS14570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CLM74_RS14575	COG0402	S-adenosylhomocysteine deaminase activity
CLM74_RS14580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLM74_RS14585	COG1509	lysine 2,3-aminomutase activity
CLM74_RS14590	COG5001	Diguanylate cyclase
CLM74_RS14590	COG3300	MHYT domain
CLM74_RS14605	COG0483	inositol monophosphate 1-phosphatase activity
CLM74_RS14610	COG0501	Belongs to the peptidase M48B family
CLM74_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS14640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLM74_RS14650	COG0802	atpase or kinase
CLM74_RS14655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLM74_RS14655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLM74_RS14660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLM74_RS14665	COG1570	exodeoxyribonuclease VII activity
CLM74_RS14675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLM74_RS14685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLM74_RS14695	COG4771	TonB-dependent receptor
CLM74_RS14700	COG1309	transcriptional regulator
CLM74_RS14725	COG2130	NADP-dependent
CLM74_RS14750	COG1960	acyl-CoA dehydrogenase activity
CLM74_RS14765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLM74_RS14805	COG2076	Multidrug Resistance protein
CLM74_RS14815	COG1280	lysine exporter protein (LysE YggA)
CLM74_RS14825	COG1794	racemase activity, acting on amino acids and derivatives
CLM74_RS14865	COG0776	regulation of translation
CLM74_RS14875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLM74_RS14880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLM74_RS14890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLM74_RS14895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLM74_RS14940	COG1185	polyribonucleotide nucleotidyltransferase activity
CLM74_RS14945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLM74_RS14955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLM74_RS14960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLM74_RS14965	COG0195	Participates in both transcription termination and antitermination
CLM74_RS14970	COG0779	Required for maturation of 30S ribosomal subunits
CLM74_RS14985	COG1007	ATP synthesis coupled electron transport
CLM74_RS15010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLM74_RS15015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CLM74_RS15025	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CLM74_RS15030	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CLM74_RS15035	COG0649	NAD binding
CLM74_RS15040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLM74_RS15045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLM74_RS15050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLM74_RS15065	COG0149	triose-phosphate isomerase activity
CLM74_RS15085	COG0438	transferase activity, transferring glycosyl groups
CLM74_RS15090	COG0726	polysaccharide deacetylase
CLM74_RS15095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLM74_RS15100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLM74_RS15105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLM74_RS15110	COG0159	tryptophan synthase activity
CLM74_RS15120	COG0133	tryptophan synthase activity
CLM74_RS15160	COG0135	phosphoribosylanthranilate isomerase activity
CLM74_RS15165	COG0101	tRNA pseudouridine synthase activity
CLM74_RS15180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLM74_RS15190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLM74_RS15195	COG2890	protein-(glutamine-N5) methyltransferase activity
CLM74_RS15200	COG1999	signal sequence binding
CLM74_RS15205	COG0688	phosphatidylethanolamine metabolic process
CLM74_RS15220	COG0433	COG0433 Predicted ATPase
CLM74_RS15225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLM74_RS15235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLM74_RS15245	COG0412	Dienelactone hydrolase
CLM74_RS15255	COG0717	Belongs to the dCTP deaminase family
CLM74_RS15260	COG0489	protein tyrosine kinase activity
CLM74_RS15265	COG4771	TonB-dependent receptor
CLM74_RS15270	COG4771	TonB-dependent receptor
CLM74_RS15275	COG4771	TonB-dependent receptor
CLM74_RS15285	COG4771	TonB-dependent receptor
CLM74_RS15290	COG4771	TonB-dependent receptor
CLM74_RS15295	COG3590	peptidase
CLM74_RS15330	COG0697	spore germination
CLM74_RS15340	COG2311	Membrane
CLM74_RS15345	COG1047	Peptidyl-prolyl cis-trans
CLM74_RS15350	COG0791	NLP P60 protein
CLM74_RS15355	COG0791	NLP P60 protein
CLM74_RS15395	COG1301	dicarboxylic acid transport
CLM74_RS15420	COG1722	exodeoxyribonuclease VII activity
CLM74_RS15425	COG0142	geranyltranstransferase activity
CLM74_RS15435	COG0312	modulator of DNA gyrase
CLM74_RS15440	COG3028	Belongs to the UPF0307 family
CLM74_RS15445	COG0312	modulator of DNA gyrase
CLM74_RS15465	COG2968	Membrane
CLM74_RS15475	COG4771	TonB-dependent receptor
CLM74_RS15485	COG0657	acetylesterase activity
CLM74_RS15485	COG2755	lipolytic protein G-D-S-L family
CLM74_RS15495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLM74_RS15505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLM74_RS15520	COG0495	leucyl-tRNA aminoacylation
CLM74_RS15530	COG3118	belongs to the thioredoxin family
CLM74_RS15540	COG4251	negative regulation of phosphorylation
CLM74_RS15540	COG3706	GGDEF domain
CLM74_RS15540	COG2203	Gaf domain
CLM74_RS15540	COG5001	Diguanylate cyclase
CLM74_RS15565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CLM74_RS15580	COG0346	lactoylglutathione lyase activity
CLM74_RS15590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLM74_RS15590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLM74_RS15600	COG2878	Part of a membrane complex involved in electron transport
CLM74_RS15610	COG0251	oxidation-reduction process
CLM74_RS15615	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CLM74_RS15615	COG0392	lysyltransferase activity
CLM74_RS15645	COG2824	Alkylphosphonate utilization operon protein PhnA
CLM74_RS15650	COG0443	Heat shock 70 kDa protein
CLM74_RS15695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLM74_RS15700	COG3122	Protein conserved in bacteria
CLM74_RS15705	COG1451	nucleotide metabolic process
CLM74_RS15715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLM74_RS15735	COG0183	Belongs to the thiolase family
CLM74_RS15750	COG1960	acyl-CoA dehydrogenase activity
CLM74_RS15760	COG1793	dna ligase
CLM74_RS15765	COG1201	RNA secondary structure unwinding
CLM74_RS15780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLM74_RS15785	COG1278	Cold shock
CLM74_RS15790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CLM74_RS15795	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CLM74_RS15800	COG1472	Belongs to the glycosyl hydrolase 3 family
CLM74_RS15805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CLM74_RS15810	COG2954	triphosphatase activity
CLM74_RS15820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLM74_RS15825	COG0745	RESPONSE REGULATOR receiver
CLM74_RS15830	COG1381	Involved in DNA repair and RecF pathway recombination
CLM74_RS15835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLM74_RS15850	COG0681	Belongs to the peptidase S26 family
CLM74_RS15855	COG0481	GTPase activity
CLM74_RS15860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLM74_RS15875	COG1024	Enoyl-CoA hydratase
CLM74_RS15875	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLM74_RS15885	COG1741	Belongs to the pirin family
CLM74_RS15890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLM74_RS15900	COG1741	Belongs to the pirin family
CLM74_RS15910	COG1966	Carbon starvation protein
CLM74_RS15915	COG2879	small protein
CLM74_RS15935	COG2205	protein histidine kinase activity
CLM74_RS15940	COG0745	RESPONSE REGULATOR receiver
CLM74_RS15945	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLM74_RS15975	COG2814	Major facilitator Superfamily
CLM74_RS15980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLM74_RS15980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLM74_RS15990	COG1113	amino acid transport
CLM74_RS15995	COG2207	Transcriptional regulator
CLM74_RS15995	COG1917	Cupin 2, conserved barrel domain protein
CLM74_RS16000	COG0753	catalase activity
CLM74_RS16030	COG1376	ErfK ybiS ycfS ynhG family protein
CLM74_RS16035	COG0739	heme binding
CLM74_RS16045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLM74_RS16055	COG0330	HflC and HflK could
CLM74_RS16060	COG0330	HflC and HflK could
CLM74_RS16065	COG0604	alcohol dehydrogenase
CLM74_RS16090	COG4953	penicillin-binding protein 1C
CLM74_RS16095	COG2373	Large extracellular alpha-helical protein
CLM74_RS16100	COG2079	MmgE PrpD family protein
CLM74_RS16105	COG2828	Protein conserved in bacteria
CLM74_RS16130	COG3829	transcription factor binding
CLM74_RS16160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLM74_RS16180	COG0477	Major facilitator Superfamily
CLM74_RS16195	COG0784	Response regulator, receiver
CLM74_RS16195	COG2198	Histidine kinase
CLM74_RS16195	COG2205	protein histidine kinase activity
CLM74_RS16205	COG3038	cytochrome b561
CLM74_RS16220	COG1760	l-serine dehydratase
CLM74_RS16225	COG0596	Alpha beta hydrolase
CLM74_RS16230	COG0460	homoserine dehydrogenase
CLM74_RS16230	COG0527	aspartate kinase activity
CLM74_RS16235	COG0626	cystathionine gamma-synthase activity
CLM74_RS16240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLM74_RS16245	COG0739	heme binding
CLM74_RS16250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLM74_RS16255	COG1272	protein, Hemolysin III
CLM74_RS16260	COG2982	Protein involved in outer membrane biogenesis
CLM74_RS16270	COG0463	Glycosyl transferase, family 2
CLM74_RS16280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLM74_RS16290	COG4771	TonB-dependent receptor
CLM74_RS16295	COG1309	transcriptional regulator
CLM74_RS16305	COG1960	acyl-CoA dehydrogenase activity
CLM74_RS16340	COG0583	DNA-binding transcription factor activity
CLM74_RS16350	COG0509	glycine decarboxylation via glycine cleavage system
CLM74_RS16355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLM74_RS16365	COG0330	HflC and HflK could
CLM74_RS16370	COG2186	Transcriptional regulator
CLM74_RS16390	COG2271	Major facilitator Superfamily
CLM74_RS16410	COG1742	UPF0060 membrane protein
CLM74_RS16415	COG3956	TIGRFAM MazG family protein
CLM74_RS16420	COG1218	3'(2'),5'-bisphosphate nucleotidase
CLM74_RS16425	COG0494	nUDIX hydrolase
CLM74_RS16435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLM74_RS16450	COG0784	Response regulator, receiver
CLM74_RS16450	COG0643	Histidine kinase
CLM74_RS16450	COG2198	Histidine kinase
CLM74_RS16455	COG0840	transmembrane signaling receptor activity
CLM74_RS16460	COG0835	chemotaxis
CLM74_RS16475	COG0189	ligase activity
CLM74_RS16490	COG1199	ATP-dependent helicase activity
CLM74_RS16500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLM74_RS16520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLM74_RS16530	COG1643	Atp-dependent helicase
CLM74_RS16535	COG0783	Belongs to the Dps family
CLM74_RS16540	COG0514	ATP-dependent DNA helicase (RecQ)
CLM74_RS16550	COG2132	Multicopper oxidase
CLM74_RS16610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLM74_RS16615	COG0602	queuosine metabolic process
CLM74_RS16625	COG2885	chlorophyll binding
CLM74_RS16630	COG0823	Involved in the tonB-independent uptake of proteins
CLM74_RS16650	COG0824	Thioesterase
CLM74_RS16655	COG2255	four-way junction helicase activity
CLM74_RS16670	COG0632	four-way junction helicase activity
CLM74_RS16675	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLM74_RS16680	COG0217	transcriptional regulatory protein
CLM74_RS16700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLM74_RS16715	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CLM74_RS16730	COG0488	(ABC) transporter
CLM74_RS16740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CLM74_RS16740	COG4651	solute:proton antiporter activity
CLM74_RS16755	COG0745	RESPONSE REGULATOR receiver
CLM74_RS16760	COG2205	protein histidine kinase activity
CLM74_RS16770	COG0542	response to heat
CLM74_RS16790	COG0028	Belongs to the TPP enzyme family
CLM74_RS16820	COG3387	PFAM Glycoside hydrolase 15-related
CLM74_RS16825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CLM74_RS16840	COG0564	pseudouridine synthase activity
CLM74_RS16845	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLM74_RS16855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLM74_RS16855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLM74_RS16860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CLM74_RS16865	COG0045	succinate-CoA ligase (ADP-forming) activity
CLM74_RS16885	COG4969	Belongs to the N-Me-Phe pilin family
CLM74_RS16895	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLM74_RS16915	COG0745	RESPONSE REGULATOR receiver
CLM74_RS16930	COG0189	ligase activity
CLM74_RS16960	COG2022	thiamine diphosphate biosynthetic process
CLM74_RS16965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLM74_RS16970	COG3273	potassium ion transport
CLM74_RS16970	COG0471	metal ion transport
CLM74_RS16990	COG1970	mechanosensitive ion channel activity
CLM74_RS17000	COG1115	amino acid carrier protein
CLM74_RS17010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLM74_RS17015	COG1115	amino acid carrier protein
CLM74_RS17025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM74_RS17045	COG0583	DNA-binding transcription factor activity
CLM74_RS17055	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLM74_RS17065	COG3588	fructose-bisphosphate aldolase
CLM74_RS17070	COG0469	pyruvate kinase activity
CLM74_RS17080	COG0126	phosphoglycerate kinase activity
CLM74_RS17095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLM74_RS17100	COG3047	cAMP biosynthetic process
CLM74_RS17145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLM74_RS17150	COG1301	dicarboxylic acid transport
CLM74_RS17160	COG2304	oxidoreductase activity
CLM74_RS17180	COG0714	Associated with various cellular activities
CLM74_RS17210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CLM74_RS17270	COG0254	rRNA binding
CLM74_RS17280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLM74_RS17290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLM74_RS17295	COG1758	RNA polymerase activity
CLM74_RS17305	COG1561	YicC-like family, N-terminal region
CLM74_RS17310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CLM74_RS17315	COG0346	lactoylglutathione lyase activity
CLM74_RS17325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLM74_RS17340	COG0006	proline dipeptidase activity
CLM74_RS17345	COG0006	proline dipeptidase activity
CLM74_RS17350	COG3079	Belongs to the UPF0149 family
CLM74_RS17370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLM74_RS17380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CLM74_RS17390	COG2912	Transglutaminase-like superfamily
CLM74_RS17395	COG1773	rubredoxin
CLM74_RS17405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLM74_RS17410	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CLM74_RS17420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLM74_RS17425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM74_RS17430	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS17450	COG0671	phosphoesterase, PA-phosphatase related
CLM74_RS17460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLM74_RS17465	COG0563	adenylate kinase activity
CLM74_RS17485	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CLM74_RS17495	COG0848	biopolymer transport protein
CLM74_RS17505	COG2832	Protein of unknown function (DUF454)
CLM74_RS17545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CLM74_RS17555	COG4771	TonB-dependent receptor
CLM74_RS17565	COG0745	RESPONSE REGULATOR receiver
CLM74_RS17575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLM74_RS17580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLM74_RS17585	COG0405	Gamma-glutamyltransferase
CLM74_RS17590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLM74_RS17610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLM74_RS17615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CLM74_RS17630	COG0473	3-isopropylmalate dehydrogenase activity
CLM74_RS17650	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM74_RS17665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLM74_RS17670	COG1538	Outer membrane efflux protein
CLM74_RS17680	COG1519	Transferase
CLM74_RS17685	COG1560	Kdo2-lipid A biosynthetic process
CLM74_RS17730	COG1301	dicarboxylic acid transport
CLM74_RS17740	COG4191	Histidine kinase
CLM74_RS17760	COG0642	Histidine kinase
CLM74_RS17775	COG2851	Citrate transporter
CLM74_RS17780	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS17795	COG1162	GTPase activity
CLM74_RS17815	COG0726	polysaccharide deacetylase
CLM74_RS17820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CLM74_RS17835	COG1228	amidohydrolase
CLM74_RS17840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLM74_RS17850	COG1307	EDD domain protein, DegV family
CLM74_RS17890	COG2203	Gaf domain
CLM74_RS17890	COG5001	Diguanylate cyclase
CLM74_RS17890	COG4251	negative regulation of phosphorylation
CLM74_RS17890	COG3706	GGDEF domain
CLM74_RS17900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CLM74_RS17905	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CLM74_RS17915	COG0583	DNA-binding transcription factor activity
CLM74_RS17920	COG1902	pentaerythritol trinitrate reductase activity
CLM74_RS17940	COG0583	DNA-binding transcription factor activity
CLM74_RS17945	COG1064	alcohol dehydrogenase
CLM74_RS17970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM74_RS17975	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLM74_RS17990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CLM74_RS18005	COG1522	sequence-specific DNA binding
CLM74_RS18015	COG4773	Receptor
CLM74_RS18035	COG0617	tRNA 3'-terminal CCA addition
CLM74_RS18065	COG3468	outer membrane autotransporter barrel domain protein
CLM74_RS18075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLM74_RS18080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLM74_RS18085	COG1609	Transcriptional regulator
CLM74_RS18095	COG0837	glucose binding
CLM74_RS18105	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CLM74_RS18125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLM74_RS18140	COG0784	Response regulator, receiver
CLM74_RS18145	COG4251	negative regulation of phosphorylation
CLM74_RS18150	COG2823	Periplasmic or secreted lipoprotein
CLM74_RS18155	COG0673	inositol 2-dehydrogenase activity
CLM74_RS18160	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CLM74_RS18180	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CLM74_RS18190	COG2921	Belongs to the UPF0250 family
CLM74_RS18200	COG1686	Belongs to the peptidase S11 family
CLM74_RS18210	COG2951	lytic endotransglycosylase activity
CLM74_RS18215	COG0772	Belongs to the SEDS family
CLM74_RS18225	COG0772	Belongs to the SEDS family
CLM74_RS18240	COG1792	Involved in formation and maintenance of cell shape
CLM74_RS18245	COG1077	Cell shape determining protein MreB Mrl
CLM74_RS18250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLM74_RS18255	COG1368	sulfuric ester hydrolase activity
CLM74_RS18260	COG0546	phosphoglycolate phosphatase activity
CLM74_RS18270	COG0308	aminopeptidase N
CLM74_RS18275	COG2226	methyltransferase
CLM74_RS18305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM74_RS18310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM74_RS18325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLM74_RS18345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLM74_RS18355	COG2832	Protein of unknown function (DUF454)
CLM74_RS18365	COG0436	Aminotransferase
CLM74_RS18370	COG1505	serine-type exopeptidase activity
CLM74_RS18385	COG2011	ABC-type metal ion transport system permease component
CLM74_RS18390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLM74_RS18395	COG0697	spore germination
CLM74_RS18400	COG1666	GTP binding
CLM74_RS18435	COG0339	signal peptide processing
CLM74_RS18445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLM74_RS18465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLM74_RS18475	COG1136	(ABC) transporter
CLM74_RS18485	COG1136	(ABC) transporter
CLM74_RS18485	COG0577	efflux transmembrane transporter activity
CLM74_RS18495	COG2204	response regulator
CLM74_RS18500	COG4191	Histidine kinase
CLM74_RS18510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLM74_RS18520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLM74_RS18525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLM74_RS18530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLM74_RS18535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLM74_RS18540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLM74_RS18545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLM74_RS18555	COG0356	it plays a direct role in the translocation of protons across the membrane
CLM74_RS18570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLM74_RS18575	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLM74_RS18595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLM74_RS18620	COG0181	hydroxymethylbilane synthase activity
CLM74_RS18630	COG3275	phosphorelay sensor kinase activity
CLM74_RS18635	COG0400	carboxylic ester hydrolase activity
CLM74_RS18645	COG4771	TonB-dependent receptor
CLM74_RS18655	COG0840	transmembrane signaling receptor activity
CLM74_RS18690	COG0583	DNA-binding transcription factor activity
CLM74_RS18705	COG1764	response to oxidative stress
CLM74_RS18715	COG0583	DNA-binding transcription factor activity
CLM74_RS18735	COG1595	DNA-templated transcription, initiation
CLM74_RS18745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM74_RS18785	COG0625	glutathione transferase activity
CLM74_RS18795	COG1733	regulation of RNA biosynthetic process
CLM74_RS18885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLM74_RS18890	COG1490	D-aminoacyl-tRNA deacylase activity
CLM74_RS18930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLM74_RS18935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLM74_RS18935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLM74_RS18940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLM74_RS18945	COG0242	peptide deformylase activity
CLM74_RS18950	COG1652	LysM domain
CLM74_RS18955	COG0758	DNA mediated transformation
CLM74_RS18960	COG2922	Belongs to the Smg family
CLM74_RS18970	COG1714	RDD family
CLM74_RS18975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLM74_RS18975	COG1754	DNA topoisomerase type I activity
CLM74_RS18980	COG0009	L-threonylcarbamoyladenylate synthase
CLM74_RS19005	COG0616	signal peptide processing
CLM74_RS19010	COG0534	Mate efflux family protein
CLM74_RS19025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLM74_RS19030	COG0625	glutathione transferase activity
CLM74_RS19045	COG1252	NADH dehydrogenase
CLM74_RS19065	COG2860	membrane
CLM74_RS19075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM74_RS19080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLM74_RS19085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CLM74_RS19100	COG1846	Transcriptional regulator
CLM74_RS19110	COG0459	protein refolding
CLM74_RS19115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLM74_RS19120	COG2356	endonuclease I
CLM74_RS19125	COG1324	tolerance protein
CLM74_RS19135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM74_RS19145	COG0840	transmembrane signaling receptor activity
CLM74_RS19165	COG0583	DNA-binding transcription factor activity
CLM74_RS19180	COG1686	Belongs to the peptidase S11 family
CLM74_RS19195	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLM74_RS19215	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLM74_RS19225	COG0511	ligase activity, forming carbon-carbon bonds
CLM74_RS19230	COG0439	Biotin carboxylase
CLM74_RS19245	COG2264	protein methyltransferase activity
CLM74_RS19255	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CLM74_RS19260	COG4589	Belongs to the CDS family
CLM74_RS19275	COG0671	phosphoesterase, PA-phosphatase related
CLM74_RS19275	COG2453	phosphatase
CLM74_RS19280	COG2267	carboxylic ester hydrolase activity
CLM74_RS19285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLM74_RS19290	COG0138	bifunctional purine biosynthesis protein purh
CLM74_RS19300	COG0151	Belongs to the GarS family
CLM74_RS19305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLM74_RS19310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLM74_RS19315	COG2201	protein-glutamate methylesterase activity
CLM74_RS19320	COG2177	Part of the ABC transporter FtsEX involved in
CLM74_RS19325	COG2884	Cell division ATP-binding protein ftsE
CLM74_RS19340	COG3118	belongs to the thioredoxin family
CLM74_RS19345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLM74_RS19355	COG3706	GGDEF domain
CLM74_RS19370	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CLM74_RS19410	COG1652	LysM domain
CLM74_RS19415	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLM74_RS19415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLM74_RS19420	COG1473	amidohydrolase
CLM74_RS19425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLM74_RS19445	COG1289	transmembrane transporter activity
CLM74_RS19450	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS19485	COG0316	Belongs to the HesB IscA family
CLM74_RS19510	COG2205	protein histidine kinase activity
CLM74_RS19510	COG0784	Response regulator, receiver
CLM74_RS19510	COG5002	protein histidine kinase activity
CLM74_RS19530	COG1051	belongs to the nudix hydrolase family
CLM74_RS19545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLM74_RS19550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLM74_RS19555	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CLM74_RS19565	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CLM74_RS19570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM74_RS19575	COG0730	response to heat
CLM74_RS19585	COG0134	indole-3-glycerol-phosphate synthase activity
CLM74_RS19590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLM74_RS19605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLM74_RS19620	COG1597	lipid kinase activity
CLM74_RS19640	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CLM74_RS19645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLM74_RS19655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLM74_RS19655	COG2111	Na H antiporter
CLM74_RS19660	COG1006	Multisubunit Na H antiporter MnhC subunit
CLM74_RS19665	COG0651	ATP synthesis coupled electron transport
CLM74_RS19670	COG1863	multisubunit Na H antiporter MnhE subunit
CLM74_RS19675	COG2212	antiporter activity
CLM74_RS19680	COG1320	monovalent cation:proton antiporter activity
CLM74_RS19700	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CLM74_RS19730	COG3104	oligopeptide transport
CLM74_RS19735	COG3483	tryptophan 2,3-dioxygenase activity
CLM74_RS19740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CLM74_RS19765	COG2378	regulation of single-species biofilm formation
CLM74_RS19780	COG2354	Protein conserved in bacteria
CLM74_RS19790	COG1368	sulfuric ester hydrolase activity
CLM74_RS19800	COG3264	Mechanosensitive ion channel
CLM74_RS19800	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CLM74_RS19815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM74_RS19815	COG0723	plastoquinol--plastocyanin reductase activity
CLM74_RS19830	COG3212	peptidase
CLM74_RS19850	COG1166	arginine decarboxylase activity
CLM74_RS19855	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLM74_RS19870	COG0347	Belongs to the P(II) protein family
CLM74_RS19875	COG2960	long-chain fatty acid transporting porin activity
CLM74_RS19885	COG3209	COG3209 Rhs family protein
CLM74_RS19915	COG0577	efflux transmembrane transporter activity
CLM74_RS19915	COG1136	(ABC) transporter
CLM74_RS19950	COG0606	chelatase, subunit chli
CLM74_RS19980	COG0561	phosphatase activity
CLM74_RS19985	COG3932	Exopolysaccharide synthesis, ExoD
CLM74_RS20025	COG1999	signal sequence binding
CLM74_RS20030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CLM74_RS20035	COG1845	cytochrome c oxidase, subunit III
CLM74_RS20045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CLM74_RS20050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM74_RS20065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM74_RS20070	COG1104	cysteine desulfurase activity
CLM74_RS20100	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLM74_RS20120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLM74_RS20125	COG2031	fatty acid transporter
CLM74_RS20190	COG0673	inositol 2-dehydrogenase activity
CLM74_RS20200	COG1501	Belongs to the glycosyl hydrolase 31 family
CLM74_RS20205	COG2222	sugar isomerase
CLM74_RS20210	COG1940	carbohydrate kinase activity
CLM74_RS20220	COG1349	DNA-binding transcription factor activity
CLM74_RS20225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLM74_RS20230	COG2814	Major facilitator Superfamily
CLM74_RS20275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLM74_RS20280	COG0156	8-amino-7-oxononanoate synthase activity
CLM74_RS20285	COG2267	carboxylic ester hydrolase activity
CLM74_RS20290	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS20305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLM74_RS20325	COG3541	Predicted nucleotidyltransferase
CLM74_RS20330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CLM74_RS20355	COG0714	Associated with various cellular activities
CLM74_RS20370	COG0754	glutathionylspermidine amidase activity
CLM74_RS20385	COG0129	dihydroxy-acid dehydratase activity
CLM74_RS20395	COG1199	ATP-dependent helicase activity
CLM74_RS20405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLM74_RS20425	COG3781	membrane
CLM74_RS20455	COG0625	glutathione transferase activity
CLM74_RS20475	COG2207	Transcriptional regulator
CLM74_RS20485	COG4555	ABC transporter
CLM74_RS20520	COG1131	(ABC) transporter
CLM74_RS20525	COG0842	Transport permease protein
CLM74_RS20535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLM74_RS20545	COG0084	hydrolase, TatD family'
CLM74_RS20550	COG1643	Atp-dependent helicase
CLM74_RS20560	COG1187	pseudouridine synthase activity
CLM74_RS20570	COG0667	Aldo Keto reductase
CLM74_RS20590	COG0583	DNA-binding transcription factor activity
CLM74_RS20595	COG2814	Major facilitator Superfamily
CLM74_RS20605	COG0784	Response regulator, receiver
CLM74_RS20605	COG2205	protein histidine kinase activity
CLM74_RS20605	COG2198	Histidine kinase
CLM74_RS20620	COG2267	carboxylic ester hydrolase activity
CLM74_RS20625	COG0393	Putative heavy-metal-binding
CLM74_RS20630	COG1042	CoA-binding domain protein
CLM74_RS20630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLM74_RS20630	COG0045	succinate-CoA ligase (ADP-forming) activity
CLM74_RS20635	COG2239	Acts as a magnesium transporter
CLM74_RS20650	COG3177	Filamentation induced by cAMP protein fic
CLM74_RS20650	COG0666	response to abiotic stimulus
CLM74_RS20655	COG3100	YcgL domain-containing protein
CLM74_RS20670	COG1028	Short-chain dehydrogenase reductase Sdr
CLM74_RS20690	COG0644	oxidoreductase
CLM74_RS20710	COG2986	histidine ammonia-lyase
CLM74_RS20720	COG0463	Glycosyl transferase, family 2
CLM74_RS20725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLM74_RS20735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLM74_RS20740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLM74_RS20755	COG1294	oxidase, subunit
CLM74_RS20760	COG1271	oxidase subunit
CLM74_RS20770	COG1595	DNA-templated transcription, initiation
CLM74_RS20805	COG0408	coproporphyrinogen oxidase activity
CLM74_RS20810	COG2323	membrane
CLM74_RS20830	COG0589	response to stress
CLM74_RS20840	COG1690	Belongs to the RtcB family
CLM74_RS20850	COG4650	regulator
CLM74_RS20865	COG0210	DNA helicase
CLM74_RS20875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLM74_RS20880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLM74_RS20885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLM74_RS20895	COG1819	glycosyl
CLM74_RS20905	COG0251	oxidation-reduction process
CLM74_RS20940	COG0463	Glycosyl transferase, family 2
CLM74_RS20955	COG1475	DNA binding
CLM74_RS20960	COG1192	Involved in chromosome partitioning
CLM74_RS20965	COG0357	Ribosomal RNA small subunit methyltransferase G
CLM74_RS20970	COG2091	lysine biosynthetic process via aminoadipic acid
CLM74_RS21010	COG1971	Probably functions as a manganese efflux pump
CLM74_RS21015	COG0784	Response regulator, receiver
CLM74_RS21015	COG2205	protein histidine kinase activity
CLM74_RS21025	COG2911	Protein conserved in bacteria
CLM74_RS21030	COG0729	surface antigen
CLM74_RS21040	COG0752	glycyl-tRNA synthetase alpha subunit
CLM74_RS21045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLM74_RS21050	COG0519	Catalyzes the synthesis of GMP from XMP
CLM74_RS21050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLM74_RS21060	COG0805	protein transport
CLM74_RS21070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLM74_RS21080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CLM74_RS21090	COG0840	transmembrane signaling receptor activity
CLM74_RS21145	COG3135	benzoate transporter
CLM74_RS21155	COG0676	glucose-6-phosphate 1-epimerase activity
CLM74_RS21160	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CLM74_RS21165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLM74_RS21200	COG0302	gtp cyclohydrolase
CLM74_RS21220	COG1566	PFAM secretion protein HlyD family protein
CLM74_RS21230	COG1289	transmembrane transporter activity
CLM74_RS21245	COG1074	ATP-dependent DNA helicase activity
CLM74_RS21250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CLM74_RS21255	COG1127	ABC transporter
CLM74_RS21260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLM74_RS21265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CLM74_RS21280	COG2853	Lipoprotein
CLM74_RS21285	COG0386	Belongs to the glutathione peroxidase family
CLM74_RS21295	COG1322	Protein conserved in bacteria
CLM74_RS21310	COG0583	DNA-binding transcription factor activity
CLM74_RS21325	COG0667	Aldo Keto reductase
CLM74_RS21335	COG0531	amino acid
CLM74_RS21355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLM74_RS21360	COG0861	Integral membrane protein TerC family
CLM74_RS21370	COG0584	glycerophosphoryl diester phosphodiesterase
CLM74_RS21395	COG0706	membrane insertase activity
CLM74_RS21400	COG0594	ribonuclease P activity
CLM74_RS21405	COG0230	Belongs to the bacterial ribosomal protein bL34 family