locus-tag	class	description
M1L61_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M1L61_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M1L61_RS00020	COG0187	DNA topoisomerase II activity
M1L61_RS00030	COG0501	Belongs to the peptidase M48B family
M1L61_RS00140	COG0659	secondary active sulfate transmembrane transporter activity
M1L61_RS00155	COG0798	PFAM Bile acid sodium symporter
M1L61_RS00170	COG0431	NADPH-dependent FMN reductase
M1L61_RS00185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1L61_RS00205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1L61_RS00220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1L61_RS00220	COG3453	Protein conserved in bacteria
M1L61_RS00240	COG0640	Transcriptional regulator
M1L61_RS00260	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M1L61_RS00270	COG4772	TonB-dependent receptor
M1L61_RS00305	COG0800	Aldolase
M1L61_RS00310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1L61_RS00330	COG2272	Belongs to the type-B carboxylesterase lipase family
M1L61_RS00345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M1L61_RS00360	COG3507	Belongs to the glycosyl hydrolase 43 family
M1L61_RS00365	COG1609	Transcriptional regulator
M1L61_RS00375	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS00380	COG2755	lipolytic protein G-D-S-L family
M1L61_RS00390	COG3186	Phenylalanine-4-hydroxylase
M1L61_RS00395	COG1522	sequence-specific DNA binding
M1L61_RS00405	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1L61_RS00420	COG0671	phosphoesterase, PA-phosphatase related
M1L61_RS00435	COG1119	ATPase activity
M1L61_RS00450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M1L61_RS00455	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M1L61_RS00465	COG1435	thymidine kinase activity
M1L61_RS00470	COG0210	DNA helicase
M1L61_RS00485	COG3132	Protein of unknown function, DUF480
M1L61_RS00490	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M1L61_RS00495	COG0284	orotidine-5'-phosphate decarboxylase activity
M1L61_RS00505	COG2937	Belongs to the GPAT DAPAT family
M1L61_RS00515	COG0037	tRNA processing
M1L61_RS00520	COG2974	May be involved in recombination
M1L61_RS00530	COG1803	Methylglyoxal synthase
M1L61_RS00535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1L61_RS00535	COG2205	protein histidine kinase activity
M1L61_RS00540	COG0493	'glutamate synthase
M1L61_RS00545	COG0067	glutamate synthase
M1L61_RS00545	COG0069	glutamate synthase activity
M1L61_RS00545	COG0070	glutamate synthase
M1L61_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS00595	COG1111	helicase
M1L61_RS00595	COG1205	dead DEAH box helicase
M1L61_RS00635	COG0714	Associated with various cellular activities
M1L61_RS00655	COG0312	modulator of DNA gyrase
M1L61_RS00675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1L61_RS00695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1L61_RS00735	COG1968	undecaprenyl-diphosphatase activity
M1L61_RS00740	COG0174	glutamine synthetase
M1L61_RS00745	COG0347	Belongs to the P(II) protein family
M1L61_RS00750	COG0004	ammonium transporteR
M1L61_RS00755	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1L61_RS00760	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M1L61_RS00775	COG3852	Histidine kinase
M1L61_RS00780	COG2204	response regulator
M1L61_RS00785	COG2032	superoxide dismutase activity
M1L61_RS00790	COG2032	superoxide dismutase activity
M1L61_RS00800	COG0183	Belongs to the thiolase family
M1L61_RS00835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M1L61_RS00840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M1L61_RS00860	COG0798	PFAM Bile acid sodium symporter
M1L61_RS00880	COG0431	NADPH-dependent FMN reductase
M1L61_RS00915	COG2837	iron assimilation
M1L61_RS00955	COG2197	response regulator
M1L61_RS00960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1L61_RS00960	COG2205	protein histidine kinase activity
M1L61_RS00965	COG3474	cytochrome
M1L61_RS00975	COG1960	acyl-CoA dehydrogenase activity
M1L61_RS00980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1L61_RS00990	COG0612	Peptidase, M16
M1L61_RS01000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1L61_RS01005	COG0596	Alpha beta hydrolase
M1L61_RS01015	COG0318	PFAM AMP-dependent synthetase and ligase
M1L61_RS01020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1L61_RS01030	COG1181	Belongs to the D-alanine--D-alanine ligase family
M1L61_RS01070	COG0339	signal peptide processing
M1L61_RS01085	COG0681	Belongs to the peptidase S26 family
M1L61_RS01090	COG2814	Major facilitator Superfamily
M1L61_RS01095	COG0583	DNA-binding transcription factor activity
M1L61_RS01100	COG0583	DNA-binding transcription factor activity
M1L61_RS01105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1L61_RS01110	COG2224	Isocitrate lyase
M1L61_RS01115	COG3706	GGDEF domain
M1L61_RS01140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1L61_RS01145	COG1960	acyl-CoA dehydrogenase activity
M1L61_RS01165	COG0697	spore germination
M1L61_RS01175	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1L61_RS01190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1L61_RS01195	COG1280	lysine exporter protein (LysE YggA)
M1L61_RS01200	COG1607	acyl-coa hydrolase
M1L61_RS01210	COG1902	pentaerythritol trinitrate reductase activity
M1L61_RS01230	COG1335	isochorismatase
M1L61_RS01235	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1L61_RS01240	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1L61_RS01245	COG3800	Transcriptional regulator
M1L61_RS01245	COG1396	sequence-specific DNA binding
M1L61_RS01255	COG1960	acyl-CoA dehydrogenase activity
M1L61_RS01260	COG1024	Enoyl-CoA hydratase
M1L61_RS01265	COG1024	Enoyl-CoA hydratase
M1L61_RS01275	COG1764	response to oxidative stress
M1L61_RS01285	COG0659	secondary active sulfate transmembrane transporter activity
M1L61_RS01295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1L61_RS01315	COG3228	Belongs to the MtfA family
M1L61_RS01325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M1L61_RS01325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M1L61_RS01330	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M1L61_RS01375	COG3237	CsbD-like
M1L61_RS01385	COG0180	Tryptophanyl-tRNA synthetase
M1L61_RS01410	COG0477	Major facilitator Superfamily
M1L61_RS01415	COG0697	spore germination
M1L61_RS01430	COG1136	(ABC) transporter
M1L61_RS01430	COG0577	efflux transmembrane transporter activity
M1L61_RS01440	COG1136	(ABC) transporter
M1L61_RS01445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS01450	COG1131	(ABC) transporter
M1L61_RS01460	COG4585	Histidine kinase
M1L61_RS01465	COG2197	response regulator
M1L61_RS01480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M1L61_RS01485	COG0546	phosphoglycolate phosphatase activity
M1L61_RS01495	COG0628	permease
M1L61_RS01515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1L61_RS01530	COG5507	3-demethylubiquinone-9 3-methyltransferase
M1L61_RS01560	COG2814	Major facilitator Superfamily
M1L61_RS01565	COG0583	DNA-binding transcription factor activity
M1L61_RS01570	COG4807	Protein conserved in bacteria
M1L61_RS01575	COG4221	oxidoreductase activity
M1L61_RS01585	COG0018	arginyl-trna synthetase
M1L61_RS01590	COG2003	Belongs to the UPF0758 family
M1L61_RS01595	COG2197	response regulator
M1L61_RS01600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1L61_RS01605	COG0756	dUTP diphosphatase activity
M1L61_RS01620	COG2205	protein histidine kinase activity
M1L61_RS01630	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1L61_RS01635	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1L61_RS01650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M1L61_RS01655	COG0708	Exodeoxyribonuclease III
M1L61_RS01660	COG2223	nitrite transmembrane transporter activity
M1L61_RS01675	COG0739	heme binding
M1L61_RS01680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1L61_RS01725	COG4942	peptidase
M1L61_RS01730	COG0793	Belongs to the peptidase S41A family
M1L61_RS01760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1L61_RS01790	COG3346	SURF1 family
M1L61_RS01805	COG0109	protoheme IX farnesyltransferase activity
M1L61_RS01820	COG0358	DNA primase activity
M1L61_RS01825	COG1295	ribonuclease BN
M1L61_RS01840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M1L61_RS01850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M1L61_RS01855	COG0668	transmembrane transport
M1L61_RS01870	COG2133	pyrroloquinoline quinone binding
M1L61_RS01875	COG4682	membrane
M1L61_RS01885	COG0531	amino acid
M1L61_RS01895	COG1737	Transcriptional regulator
M1L61_RS01900	COG4948	Mandelate Racemase Muconate Lactonizing
M1L61_RS01950	COG5383	Protein conserved in bacteria
M1L61_RS01960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1L61_RS01965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M1L61_RS01995	COG0778	Nitroreductase
M1L61_RS02000	COG2353	YceI-like domain
M1L61_RS02010	COG2375	cellular response to nickel ion
M1L61_RS02095	COG2267	carboxylic ester hydrolase activity
M1L61_RS02160	COG0488	(ABC) transporter
M1L61_RS02165	COG0583	DNA-binding transcription factor activity
M1L61_RS02175	COG2814	Major facilitator Superfamily
M1L61_RS02180	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M1L61_RS02185	COG1113	amino acid transport
M1L61_RS02190	COG0741	lytic transglycosylase activity
M1L61_RS02215	COG2764	glyoxalase bleomycin resistance protein dioxygenase
M1L61_RS02225	COG5507	3-demethylubiquinone-9 3-methyltransferase
M1L61_RS02230	COG4941	Belongs to the sigma-70 factor family
M1L61_RS02260	COG3275	phosphorelay sensor kinase activity
M1L61_RS02265	COG3279	Response regulator of the LytR AlgR family
M1L61_RS02285	COG1309	transcriptional regulator
M1L61_RS02295	COG2814	Major facilitator Superfamily
M1L61_RS02300	COG3590	peptidase
M1L61_RS02305	COG5001	Diguanylate cyclase
M1L61_RS02310	COG0583	DNA-binding transcription factor activity
M1L61_RS02320	COG3384	dioxygenase
M1L61_RS02325	COG0025	NhaP-type Na H and K H
M1L61_RS02350	COG1360	Flagellar Motor Protein
M1L61_RS02380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1L61_RS02395	COG5002	protein histidine kinase activity
M1L61_RS02410	COG2813	Specifically methylates the guanine in position
M1L61_RS02415	COG1187	pseudouridine synthase activity
M1L61_RS02420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1L61_RS02430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M1L61_RS02435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1L61_RS02450	COG0583	DNA-binding transcription factor activity
M1L61_RS02455	COG2226	methyltransferase
M1L61_RS02480	COG1956	GAF domain-containing protein
M1L61_RS02485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M1L61_RS02490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1L61_RS02495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1L61_RS02500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1L61_RS02500	COG0785	Cytochrome C biogenesis protein
M1L61_RS02505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1L61_RS02510	COG0745	RESPONSE REGULATOR receiver
M1L61_RS02515	COG5002	protein histidine kinase activity
M1L61_RS02520	COG2205	protein histidine kinase activity
M1L61_RS02525	COG0745	RESPONSE REGULATOR receiver
M1L61_RS02530	COG0367	asparagine synthase
M1L61_RS02540	COG0720	synthase
M1L61_RS02555	COG0513	Belongs to the DEAD box helicase family
M1L61_RS02565	COG0625	glutathione transferase activity
M1L61_RS02605	COG0626	cystathionine gamma-synthase activity
M1L61_RS02640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1L61_RS02650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1L61_RS02655	COG2076	Multidrug Resistance protein
M1L61_RS02665	COG0463	Glycosyl transferase, family 2
M1L61_RS02705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1L61_RS02710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1L61_RS02740	COG1127	ABC transporter
M1L61_RS02745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1L61_RS02760	COG0442	prolyl-tRNA aminoacylation
M1L61_RS02770	COG1183	phosphatidylcholine synthase activity
M1L61_RS02780	COG0456	acetyltransferase
M1L61_RS02790	COG0525	valine-tRNA ligase activity
M1L61_RS02800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M1L61_RS02810	COG0795	lipopolysaccharide-transporting ATPase activity
M1L61_RS02820	COG4974	Belongs to the 'phage' integrase family
M1L61_RS02825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1L61_RS02835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1L61_RS02835	COG0047	phosphoribosylformylglycinamidine synthase activity
M1L61_RS02840	COG5295	Hep Hag repeat protein
M1L61_RS02845	COG1404	Belongs to the peptidase S8 family
M1L61_RS02850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1L61_RS02855	COG1459	type II secretion system
M1L61_RS02860	COG2165	general secretion pathway protein
M1L61_RS02865	COG4970	Tfp pilus assembly protein FimT
M1L61_RS02870	COG2165	general secretion pathway protein
M1L61_RS02875	COG4795	General secretion pathway protein
M1L61_RS02880	COG3156	type II secretion system protein K
M1L61_RS02885	COG3166	PFAM Fimbrial assembly family protein
M1L61_RS02900	COG1450	Type ii and iii secretion system protein
M1L61_RS02910	COG0463	Glycosyl transferase, family 2
M1L61_RS02925	COG3539	Fimbrial protein
M1L61_RS02945	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M1L61_RS02955	COG1215	transferase activity, transferring glycosyl groups
M1L61_RS02970	COG2252	PERMEase
M1L61_RS02980	COG0488	(ABC) transporter
M1L61_RS02990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M1L61_RS03005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1L61_RS03010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1L61_RS03010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1L61_RS03040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M1L61_RS03045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M1L61_RS03055	COG2205	protein histidine kinase activity
M1L61_RS03055	COG0784	Response regulator, receiver
M1L61_RS03060	COG3121	Chaperone
M1L61_RS03100	COG0277	FAD linked oxidase domain protein
M1L61_RS03105	COG1988	membrane-bound metal-dependent
M1L61_RS03140	COG2001	Belongs to the MraZ family
M1L61_RS03145	COG0275	rRNA processing
M1L61_RS03150	COG3116	cell division
M1L61_RS03160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1L61_RS03165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1L61_RS03180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M1L61_RS03185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1L61_RS03190	COG1181	Belongs to the D-alanine--D-alanine ligase family
M1L61_RS03195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1L61_RS03205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1L61_RS03210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M1L61_RS03220	COG0739	heme binding
M1L61_RS03225	COG0653	protein targeting
M1L61_RS03230	COG0494	nUDIX hydrolase
M1L61_RS03240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1L61_RS03245	COG2267	carboxylic ester hydrolase activity
M1L61_RS03250	COG3275	phosphorelay sensor kinase activity
M1L61_RS03260	COG0402	S-adenosylhomocysteine deaminase activity
M1L61_RS03280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1L61_RS03285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1L61_RS03295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M1L61_RS03300	COG1607	acyl-coa hydrolase
M1L61_RS03305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M1L61_RS03325	COG4106	trans-aconitate 2-methyltransferase activity
M1L61_RS03330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1L61_RS03350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1L61_RS03355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M1L61_RS03360	COG0667	Aldo Keto reductase
M1L61_RS03370	COG4771	TonB-dependent receptor
M1L61_RS03385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1L61_RS03390	COG4181	ATPase activity
M1L61_RS03405	COG0642	Histidine kinase
M1L61_RS03415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M1L61_RS03420	COG0861	Integral membrane protein TerC family
M1L61_RS03425	COG2814	Major facilitator Superfamily
M1L61_RS03430	COG1704	LemA family
M1L61_RS03445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M1L61_RS03450	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M1L61_RS03465	COG3738	Protein conserved in bacteria
M1L61_RS03470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1L61_RS03475	COG2967	ApaG domain
M1L61_RS03480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1L61_RS03485	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M1L61_RS03490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1L61_RS03495	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M1L61_RS03505	COG2096	Adenosyltransferase
M1L61_RS03515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1L61_RS03520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1L61_RS03525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1L61_RS03530	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M1L61_RS03555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1L61_RS03565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1L61_RS03575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1L61_RS03580	COG0583	DNA-binding transcription factor activity
M1L61_RS03585	COG3634	alkyl hydroperoxide reductase activity
M1L61_RS03645	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M1L61_RS03670	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M1L61_RS03685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1L61_RS03705	COG1404	Belongs to the peptidase S8 family
M1L61_RS03725	COG1295	ribonuclease BN
M1L61_RS03730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1L61_RS03745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M1L61_RS03750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M1L61_RS03765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M1L61_RS03775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1L61_RS03780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M1L61_RS03785	COG0193	aminoacyl-tRNA hydrolase activity
M1L61_RS03795	COG0012	GTP binding
M1L61_RS03800	COG4206	TonB-dependent receptor
M1L61_RS03805	COG4242	Belongs to the peptidase S51 family
M1L61_RS03830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M1L61_RS03845	COG0250	Participates in transcription elongation, termination and antitermination
M1L61_RS03850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M1L61_RS03855	COG0081	regulation of translation
M1L61_RS03860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M1L61_RS03865	COG0222	ribosome binding
M1L61_RS03870	COG0085	RNA polymerase activity
M1L61_RS03875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1L61_RS03880	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M1L61_RS03885	COG0049	tRNA binding
M1L61_RS03890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M1L61_RS03895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M1L61_RS03900	COG0051	transcription antitermination factor activity, RNA binding
M1L61_RS03905	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M1L61_RS03910	COG0088	Forms part of the polypeptide exit tunnel
M1L61_RS03915	COG0089	rRNA binding
M1L61_RS03920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M1L61_RS03925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M1L61_RS03930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M1L61_RS03935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M1L61_RS03940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M1L61_RS03945	COG0255	Belongs to the universal ribosomal protein uL29 family
M1L61_RS03950	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M1L61_RS03955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M1L61_RS03960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M1L61_RS03965	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M1L61_RS03970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M1L61_RS03975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M1L61_RS03980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M1L61_RS03985	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M1L61_RS03990	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M1L61_RS03995	COG1841	ribosomal large subunit assembly
M1L61_RS04000	COG0200	Binds to the 23S rRNA
M1L61_RS04005	COG0201	protein transport
M1L61_RS04010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M1L61_RS04015	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M1L61_RS04020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M1L61_RS04025	COG0202	RNA polymerase activity
M1L61_RS04030	COG0203	ribosomal protein L17
M1L61_RS04045	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M1L61_RS04055	COG0154	amidase activity
M1L61_RS04070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1L61_RS04075	COG0039	L-malate dehydrogenase activity
M1L61_RS04080	COG0564	pseudouridine synthase activity
M1L61_RS04085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1L61_RS04100	COG0625	glutathione transferase activity
M1L61_RS04110	COG1902	pentaerythritol trinitrate reductase activity
M1L61_RS04110	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1L61_RS04115	COG2364	Membrane
M1L61_RS04120	COG0604	alcohol dehydrogenase
M1L61_RS04135	COG1187	pseudouridine synthase activity
M1L61_RS04155	COG1063	alcohol dehydrogenase
M1L61_RS04165	COG0588	phosphoglycerate mutase activity
M1L61_RS04170	COG0285	dihydrofolate synthase activity
M1L61_RS04190	COG2833	Protein of unknown function (DUF455)
M1L61_RS04200	COG3291	Pkd domain containing protein
M1L61_RS04205	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1L61_RS04215	COG0438	transferase activity, transferring glycosyl groups
M1L61_RS04225	COG4206	TonB-dependent receptor
M1L61_RS04230	COG0248	Ppx GppA phosphatase
M1L61_RS04235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M1L61_RS04250	COG4783	chaperone-mediated protein folding
M1L61_RS04265	COG0473	3-isopropylmalate dehydrogenase activity
M1L61_RS04300	COG0464	growth
M1L61_RS04305	COG1404	Belongs to the peptidase S8 family
M1L61_RS04370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1L61_RS04410	COG0592	DNA-directed DNA polymerase activity
M1L61_RS04595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1L61_RS04595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1L61_RS04660	COG0544	peptidyl-prolyl cis-trans isomerase activity
M1L61_RS04665	COG0740	serine-type endopeptidase activity
M1L61_RS04670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M1L61_RS04710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1L61_RS04715	COG3942	CHAP domain
M1L61_RS04715	COG1388	LysM domain
M1L61_RS04720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1L61_RS04730	COG0328	RNA-DNA hybrid ribonuclease activity
M1L61_RS04735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1L61_RS04740	COG0631	protein serine/threonine phosphatase activity
M1L61_RS04755	COG0859	PFAM glycosyl transferase family 9
M1L61_RS04760	COG3642	lipopolysaccharide core region biosynthetic process
M1L61_RS04765	COG1234	tRNA 3'-trailer cleavage
M1L61_RS04780	COG2076	Multidrug Resistance protein
M1L61_RS04810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1L61_RS04815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M1L61_RS04825	COG0537	adenosine 5'-monophosphoramidase activity
M1L61_RS04845	COG0714	Associated with various cellular activities
M1L61_RS04860	COG1399	metal-binding, possibly nucleic acid-binding protein
M1L61_RS04865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M1L61_RS04870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1L61_RS04880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1L61_RS04895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1L61_RS04900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1L61_RS04905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1L61_RS04910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1L61_RS05025	COG1388	LysM domain
M1L61_RS05075	COG4774	siderophore transport
M1L61_RS05085	COG2223	nitrite transmembrane transporter activity
M1L61_RS05100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M1L61_RS05110	COG0583	DNA-binding transcription factor activity
M1L61_RS05115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1L61_RS05120	COG0697	spore germination
M1L61_RS05125	COG0583	DNA-binding transcription factor activity
M1L61_RS05130	COG0477	Major facilitator Superfamily
M1L61_RS05150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS05190	COG0583	DNA-binding transcription factor activity
M1L61_RS05200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M1L61_RS05215	COG0667	Aldo Keto reductase
M1L61_RS05235	COG2818	Glycosylase
M1L61_RS05240	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1L61_RS05245	COG1678	Uncharacterized ACR, COG1678
M1L61_RS05250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1L61_RS05255	COG0540	Belongs to the ATCase OTCase family
M1L61_RS05275	COG2239	Acts as a magnesium transporter
M1L61_RS05280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1L61_RS05295	COG1660	Displays ATPase and GTPase activities
M1L61_RS05300	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M1L61_RS05305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1L61_RS05310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M1L61_RS05320	COG1137	ATPase activity
M1L61_RS05335	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1L61_RS05350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1L61_RS05370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1L61_RS05390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M1L61_RS05400	COG0628	permease
M1L61_RS05410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1L61_RS05415	COG3178	'Phosphotransferase
M1L61_RS05420	COG2261	transglycosylase associated protein
M1L61_RS05430	COG1555	photosystem II stabilization
M1L61_RS05450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1L61_RS05455	COG1477	protein flavinylation
M1L61_RS05475	COG4771	TonB-dependent receptor
M1L61_RS05485	COG3128	pkhd-type hydroxylase
M1L61_RS05495	COG4774	siderophore transport
M1L61_RS05505	COG2146	nitrite reductase [NAD(P)H] activity
M1L61_RS05580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1L61_RS05585	COG0719	Fe-S assembly protein
M1L61_RS05590	COG0396	ATPase activity
M1L61_RS05595	COG0719	Fe-S assembly protein
M1L61_RS05600	COG1959	2 iron, 2 sulfur cluster binding
M1L61_RS05610	COG0693	protein deglycase activity
M1L61_RS05635	COG1764	response to oxidative stress
M1L61_RS05640	COG0384	phenazine biosynthesis protein PhzF
M1L61_RS05645	COG0384	phenazine biosynthesis protein PhzF
M1L61_RS05650	COG0527	aspartate kinase activity
M1L61_RS05660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M1L61_RS05675	COG0142	geranyltranstransferase activity
M1L61_RS05680	COG0366	Alpha amylase catalytic
M1L61_RS05690	COG1082	Xylose isomerase domain protein TIM barrel
M1L61_RS05700	COG2190	(PTS) system
M1L61_RS05700	COG2211	Major facilitator Superfamily
M1L61_RS05725	COG1131	(ABC) transporter
M1L61_RS05780	COG0629	single-stranded DNA binding
M1L61_RS05785	COG0583	DNA-binding transcription factor activity
M1L61_RS05820	COG2010	Cytochrome c
M1L61_RS05830	COG0673	inositol 2-dehydrogenase activity
M1L61_RS05835	COG2211	Major facilitator Superfamily
M1L61_RS05845	COG1609	Transcriptional regulator
M1L61_RS05880	COG3655	Transcriptional regulator
M1L61_RS05885	COG1253	flavin adenine dinucleotide binding
M1L61_RS05890	COG1408	metallophosphoesterase
M1L61_RS05895	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M1L61_RS05915	COG2259	Doxx family
M1L61_RS05945	COG0477	Major facilitator Superfamily
M1L61_RS05960	COG1802	Transcriptional regulator
M1L61_RS05995	COG3052	prosthetic group binding
M1L61_RS06010	COG0579	oxidoreductase
M1L61_RS06040	COG3104	oligopeptide transport
M1L61_RS06050	COG1297	OPT oligopeptide transporter protein
M1L61_RS06055	COG1506	peptidase
M1L61_RS06055	COG0823	Involved in the tonB-independent uptake of proteins
M1L61_RS06070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M1L61_RS06075	COG2894	cell division
M1L61_RS06080	COG0850	regulation of cytokinetic process
M1L61_RS06090	COG4585	Histidine kinase
M1L61_RS06095	COG2197	response regulator
M1L61_RS06130	COG0330	HflC and HflK could
M1L61_RS06135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M1L61_RS06145	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M1L61_RS06155	COG1595	DNA-templated transcription, initiation
M1L61_RS06165	COG1946	Acyl-CoA thioesterase
M1L61_RS06185	COG0824	Thioesterase
M1L61_RS06190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1L61_RS06195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M1L61_RS06200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M1L61_RS06205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M1L61_RS06210	COG0268	Binds directly to 16S ribosomal RNA
M1L61_RS06215	COG0728	peptidoglycan biosynthetic process
M1L61_RS06220	COG0196	riboflavin kinase activity
M1L61_RS06225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1L61_RS06235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M1L61_RS06265	COG4206	TonB-dependent receptor
M1L61_RS06285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M1L61_RS06315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1L61_RS06320	COG1845	cytochrome c oxidase, subunit III
M1L61_RS06325	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1L61_RS06340	COG0326	Molecular chaperone. Has ATPase activity
M1L61_RS06360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1L61_RS06375	COG0228	four-way junction DNA binding
M1L61_RS06380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1L61_RS06385	COG0336	Belongs to the RNA methyltransferase TrmD family
M1L61_RS06390	COG0335	large ribosomal subunit rRNA binding
M1L61_RS06410	COG0534	Mate efflux family protein
M1L61_RS06435	COG0753	catalase activity
M1L61_RS06460	COG0840	transmembrane signaling receptor activity
M1L61_RS06465	COG3134	Outer membrane lipoprotein
M1L61_RS06480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS06505	COG0024	Methionine aminopeptidase
M1L61_RS06530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1L61_RS06555	COG1647	Serine aminopeptidase, S33
M1L61_RS06580	COG2814	Major facilitator Superfamily
M1L61_RS06585	COG3706	GGDEF domain
M1L61_RS06605	COG0588	phosphoglycerate mutase activity
M1L61_RS06610	COG3590	peptidase
M1L61_RS06620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1L61_RS06630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1L61_RS06635	COG0745	RESPONSE REGULATOR receiver
M1L61_RS06640	COG2205	protein histidine kinase activity
M1L61_RS06645	COG4452	Inner membrane protein CreD
M1L61_RS06660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1L61_RS06665	COG0735	belongs to the Fur family
M1L61_RS06745	COG5002	protein histidine kinase activity
M1L61_RS06745	COG5001	Diguanylate cyclase
M1L61_RS06750	COG2199	diguanylate cyclase activity
M1L61_RS06755	COG1187	pseudouridine synthase activity
M1L61_RS06765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M1L61_RS06785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1L61_RS06790	COG1132	(ABC) transporter
M1L61_RS06855	COG1695	Transcriptional regulator
M1L61_RS06875	COG1981	membrane
M1L61_RS06880	COG0825	malonyl-CoA metabolic process
M1L61_RS06915	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1L61_RS06925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1L61_RS06935	COG0750	zinc metalloprotease
M1L61_RS06940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M1L61_RS06945	COG0575	Belongs to the CDS family
M1L61_RS06950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1L61_RS06955	COG0233	cytoplasmic translational termination
M1L61_RS06960	COG0528	UMP kinase activity
M1L61_RS06970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M1L61_RS06975	COG0052	Belongs to the universal ribosomal protein uS2 family
M1L61_RS06995	COG3188	usher protein
M1L61_RS07015	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M1L61_RS07030	COG1393	Belongs to the ArsC family
M1L61_RS07035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1L61_RS07045	COG0367	asparagine synthase
M1L61_RS07050	COG0475	glutathione-regulated potassium exporter activity
M1L61_RS07085	COG1566	PFAM secretion protein HlyD family protein
M1L61_RS07090	COG2814	Major facilitator Superfamily
M1L61_RS07105	COG0583	DNA-binding transcription factor activity
M1L61_RS07140	COG0557	exoribonuclease II activity
M1L61_RS07150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1L61_RS07155	COG1538	Outer membrane efflux protein
M1L61_RS07160	COG1136	(ABC) transporter
M1L61_RS07160	COG0577	efflux transmembrane transporter activity
M1L61_RS07165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS07185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1L61_RS07190	COG2259	Doxx family
M1L61_RS07200	COG3220	belongs to the UPF0276 family
M1L61_RS07210	COG0704	Plays a role in the regulation of phosphate uptake
M1L61_RS07220	COG0581	inorganic phosphate transmembrane transporter activity
M1L61_RS07225	COG0573	inorganic phosphate transmembrane transporter activity
M1L61_RS07230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1L61_RS07235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1L61_RS07245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1L61_RS07255	COG1024	Enoyl-CoA hydratase
M1L61_RS07285	COG0116	Belongs to the methyltransferase superfamily
M1L61_RS07285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M1L61_RS07310	COG2733	membrane
M1L61_RS07320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M1L61_RS07325	COG1012	belongs to the aldehyde dehydrogenase family
M1L61_RS07340	COG0477	Major facilitator Superfamily
M1L61_RS07345	COG2703	oxygen carrier activity
M1L61_RS07370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1L61_RS07375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M1L61_RS07380	COG0174	glutamine synthetase
M1L61_RS07390	COG2072	flavoprotein involved in K transport
M1L61_RS07395	COG3842	ATPase activity
M1L61_RS07400	COG1176	ABC-type spermidine putrescine transport system, permease component I
M1L61_RS07405	COG1177	transmembrane transport
M1L61_RS07410	COG1012	belongs to the aldehyde dehydrogenase family
M1L61_RS07425	COG4535	Mg2 and Co2 transporter CorC
M1L61_RS07440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M1L61_RS07445	COG1702	phosphate starvation-inducible protein PhoH
M1L61_RS07455	COG1131	(ABC) transporter
M1L61_RS07460	COG0842	Transport permease protein
M1L61_RS07465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1L61_RS07480	COG0741	lytic transglycosylase activity
M1L61_RS07485	COG0723	plastoquinol--plastocyanin reductase activity
M1L61_RS07490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1L61_RS07495	COG2857	Cytochrome c1
M1L61_RS07500	COG0625	glutathione transferase activity
M1L61_RS07505	COG2969	positive regulation of protein catabolic process
M1L61_RS07540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1L61_RS07550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1L61_RS07565	COG1611	Belongs to the LOG family
M1L61_RS07610	COG0556	nucleotide-excision repair
M1L61_RS07650	COG3713	MltA-interacting MipA family protein
M1L61_RS07670	COG0811	peptide transport
M1L61_RS07675	COG0848	biopolymer transport protein
M1L61_RS07685	COG1663	tetraacyldisaccharide 4'-kinase activity
M1L61_RS07690	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M1L61_RS07695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1L61_RS07705	COG0322	excinuclease ABC activity
M1L61_RS07745	COG0577	efflux transmembrane transporter activity
M1L61_RS07745	COG1136	(ABC) transporter
M1L61_RS07795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1L61_RS07840	COG4977	sequence-specific DNA binding
M1L61_RS07840	COG1917	Cupin 2, conserved barrel domain protein
M1L61_RS07845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M1L61_RS07865	COG0348	domain, Protein
M1L61_RS07880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1L61_RS07895	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1L61_RS07900	COG0069	glutamate synthase activity
M1L61_RS07925	COG1054	Belongs to the UPF0176 family
M1L61_RS07930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1L61_RS07945	COG1253	flavin adenine dinucleotide binding
M1L61_RS07955	COG0306	phosphate transporter
M1L61_RS07965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1L61_RS07980	COG0504	CTP synthase activity
M1L61_RS07985	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M1L61_RS08000	COG0148	phosphopyruvate hydratase activity
M1L61_RS08005	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1L61_RS08010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M1L61_RS08015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M1L61_RS08025	COG2840	Smr protein MutS2
M1L61_RS08030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1L61_RS08035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1L61_RS08055	COG1534	Rna-binding protein
M1L61_RS08060	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M1L61_RS08065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1L61_RS08075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1L61_RS08080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M1L61_RS08085	COG1923	regulation of RNA biosynthetic process
M1L61_RS08090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1L61_RS08095	COG1546	Belongs to the CinA family
M1L61_RS08100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1L61_RS08105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1L61_RS08110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M1L61_RS08115	COG2137	regulation of response to DNA damage stimulus
M1L61_RS08120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1L61_RS08125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M1L61_RS08150	COG4773	Receptor
M1L61_RS08165	COG1940	carbohydrate kinase activity
M1L61_RS08205	COG3540	Alkaline phosphatase
M1L61_RS08225	COG3258	Cytochrome c
M1L61_RS08240	COG2223	nitrite transmembrane transporter activity
M1L61_RS08255	COG1741	Belongs to the pirin family
M1L61_RS08260	COG0583	DNA-binding transcription factor activity
M1L61_RS08285	COG0351	phosphomethylpyrimidine kinase
M1L61_RS08285	COG0352	thiamine-phosphate diphosphorylase activity
M1L61_RS08300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M1L61_RS08305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1L61_RS08315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1L61_RS08325	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1L61_RS08330	COG0477	Major facilitator Superfamily
M1L61_RS08340	COG0617	tRNA 3'-terminal CCA addition
M1L61_RS08345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1L61_RS08350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M1L61_RS08355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M1L61_RS08365	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M1L61_RS08370	COG0166	Belongs to the GPI family
M1L61_RS08385	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M1L61_RS08395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M1L61_RS08400	COG0671	phosphoesterase, PA-phosphatase related
M1L61_RS08410	COG0800	Aldolase
M1L61_RS08415	COG0129	dihydroxy-acid dehydratase activity
M1L61_RS08425	COG0837	glucose binding
M1L61_RS08450	COG2009	succinate dehydrogenase
M1L61_RS08455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1L61_RS08460	COG1053	succinate dehydrogenase
M1L61_RS08480	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1L61_RS08495	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M1L61_RS08505	COG0552	protein localization to endoplasmic reticulum
M1L61_RS08520	COG0742	ribosomal rna small subunit methyltransferase
M1L61_RS08525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M1L61_RS08535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1L61_RS08540	COG0405	Gamma-glutamyltransferase
M1L61_RS08545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1L61_RS08565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M1L61_RS08585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1L61_RS08590	COG0415	Belongs to the DNA photolyase family
M1L61_RS08595	COG2885	chlorophyll binding
M1L61_RS08600	COG0583	DNA-binding transcription factor activity
M1L61_RS08670	COG4977	sequence-specific DNA binding
M1L61_RS08670	COG1917	Cupin 2, conserved barrel domain protein
M1L61_RS08695	COG1404	Belongs to the peptidase S8 family
M1L61_RS08725	COG0582	viral genome integration into host DNA
M1L61_RS08745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M1L61_RS08755	COG2914	Belongs to the UPF0125 (RnfH) family
M1L61_RS08760	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1L61_RS08765	COG0735	belongs to the Fur family
M1L61_RS08775	COG0583	DNA-binding transcription factor activity
M1L61_RS08780	COG0497	DNA recombination
M1L61_RS08785	COG1420	regulation of RNA biosynthetic process
M1L61_RS08790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M1L61_RS08795	COG0443	Heat shock 70 kDa protein
M1L61_RS08800	COG0484	heat shock protein binding
M1L61_RS08805	COG2207	Transcriptional regulator
M1L61_RS08810	COG2223	nitrite transmembrane transporter activity
M1L61_RS08820	COG0287	Prephenate dehydrogenase
M1L61_RS08820	COG1605	Chorismate mutase
M1L61_RS08830	COG1132	(ABC) transporter
M1L61_RS08850	COG2203	Gaf domain
M1L61_RS08850	COG3706	GGDEF domain
M1L61_RS08850	COG5001	Diguanylate cyclase
M1L61_RS08850	COG4251	negative regulation of phosphorylation
M1L61_RS08860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M1L61_RS08865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M1L61_RS08870	COG0343	queuine tRNA-ribosyltransferase activity
M1L61_RS08875	COG1862	Preprotein translocase
M1L61_RS08885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1L61_RS08890	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M1L61_RS08900	COG2081	HI0933 family
M1L61_RS08905	COG4681	YaeQ
M1L61_RS08925	COG0625	glutathione transferase activity
M1L61_RS08930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1L61_RS08935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1L61_RS08940	COG0513	Belongs to the DEAD box helicase family
M1L61_RS08950	COG0583	DNA-binding transcription factor activity
M1L61_RS08955	COG0488	(ABC) transporter
M1L61_RS08980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1L61_RS08995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1L61_RS09000	COG2957	Belongs to the agmatine deiminase family
M1L61_RS09010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M1L61_RS09015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M1L61_RS09025	COG0776	regulation of translation
M1L61_RS09035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M1L61_RS09050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1L61_RS09055	COG0183	Belongs to the thiolase family
M1L61_RS09060	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1L61_RS09060	COG1024	Enoyl-CoA hydratase
M1L61_RS09070	COG0105	UTP biosynthetic process
M1L61_RS09075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M1L61_RS09085	COG1426	Protein conserved in bacteria
M1L61_RS09090	COG2976	Protein conserved in bacteria
M1L61_RS09095	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1L61_RS09100	COG1160	GTP binding
M1L61_RS09120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M1L61_RS09125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1L61_RS09125	COG0475	glutathione-regulated potassium exporter activity
M1L61_RS09145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1L61_RS09145	COG0519	Catalyzes the synthesis of GMP from XMP
M1L61_RS09175	COG1715	Restriction endonuclease
M1L61_RS09185	COG0583	DNA-binding transcription factor activity
M1L61_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS09220	COG0596	Alpha beta hydrolase
M1L61_RS09235	COG0640	Transcriptional regulator
M1L61_RS09250	COG4716	Myosin-crossreactive antigen
M1L61_RS09265	COG0431	NADPH-dependent FMN reductase
M1L61_RS09275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1L61_RS09280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1L61_RS09285	COG1473	amidohydrolase
M1L61_RS09300	COG1126	abc transporter atp-binding protein
M1L61_RS09305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1L61_RS09325	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M1L61_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS09350	COG1309	transcriptional regulator
M1L61_RS09365	COG0697	spore germination
M1L61_RS09370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M1L61_RS09375	COG0167	dihydroorotate dehydrogenase activity
M1L61_RS09390	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS09395	COG1012	belongs to the aldehyde dehydrogenase family
M1L61_RS09400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1L61_RS09420	COG0673	inositol 2-dehydrogenase activity
M1L61_RS09425	COG0667	Aldo Keto reductase
M1L61_RS09440	COG1216	Glycosyl transferase, family 2
M1L61_RS09440	COG1442	glycosyl transferase family 8
M1L61_RS09485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1L61_RS09555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1L61_RS09765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1L61_RS09835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1L61_RS09865	COG0745	RESPONSE REGULATOR receiver
M1L61_RS09870	COG4191	Histidine kinase
M1L61_RS09870	COG0784	Response regulator, receiver
M1L61_RS09875	COG2205	protein histidine kinase activity
M1L61_RS09875	COG3437	response regulator, receiver
M1L61_RS09875	COG3850	Histidine kinase
M1L61_RS09875	COG4999	Histidine kinase
M1L61_RS09880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M1L61_RS09890	COG5002	protein histidine kinase activity
M1L61_RS09950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1L61_RS09955	COG0124	histidyl-tRNA synthetase
M1L61_RS09970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1L61_RS09975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1L61_RS09980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M1L61_RS09985	COG0131	Imidazoleglycerol-phosphate dehydratase
M1L61_RS09985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M1L61_RS09990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1L61_RS09995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M1L61_RS10000	COG0107	imidazoleglycerol-phosphate synthase activity
M1L61_RS10005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1L61_RS10005	COG0140	phosphoribosyl-ATP diphosphatase activity
M1L61_RS10025	COG1446	asparaginase
M1L61_RS10030	COG3142	Participates in the control of copper homeostasis
M1L61_RS10045	COG0789	Transcriptional regulator
M1L61_RS10060	COG3537	Alpha-1,2-mannosidase
M1L61_RS10065	COG1609	Transcriptional regulator
M1L61_RS10075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1L61_RS10090	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
M1L61_RS10095	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M1L61_RS10100	COG0235	Class ii aldolase
M1L61_RS10105	COG0531	amino acid
M1L61_RS10110	COG0531	amino acid
M1L61_RS10120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1L61_RS10125	COG0277	FAD linked oxidase domain protein
M1L61_RS10140	COG2205	protein histidine kinase activity
M1L61_RS10145	COG0745	RESPONSE REGULATOR receiver
M1L61_RS10150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS10155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1L61_RS10170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M1L61_RS10215	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1L61_RS10230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M1L61_RS10235	COG0505	Belongs to the CarA family
M1L61_RS10240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M1L61_RS10245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1L61_RS10265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1L61_RS10270	COG4676	Protein conserved in bacteria
M1L61_RS10280	COG3279	Response regulator of the LytR AlgR family
M1L61_RS10300	COG1012	belongs to the aldehyde dehydrogenase family
M1L61_RS10320	COG0784	Response regulator, receiver
M1L61_RS10320	COG2198	Histidine kinase
M1L61_RS10320	COG2205	protein histidine kinase activity
M1L61_RS10325	COG1024	Enoyl-CoA hydratase
M1L61_RS10330	COG0318	PFAM AMP-dependent synthetase and ligase
M1L61_RS10335	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
M1L61_RS10340	COG1012	belongs to the aldehyde dehydrogenase family
M1L61_RS10345	COG1309	transcriptional regulator
M1L61_RS10350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1L61_RS10390	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M1L61_RS10400	COG0840	transmembrane signaling receptor activity
M1L61_RS10415	COG0840	transmembrane signaling receptor activity
M1L61_RS10425	COG0835	chemotaxis
M1L61_RS10430	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M1L61_RS10435	COG0840	transmembrane signaling receptor activity
M1L61_RS10445	COG0745	RESPONSE REGULATOR receiver
M1L61_RS10455	COG0835	chemotaxis
M1L61_RS10465	COG1360	Flagellar Motor Protein
M1L61_RS10470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M1L61_RS10475	COG0643	Histidine kinase
M1L61_RS10475	COG0784	Response regulator, receiver
M1L61_RS10475	COG2198	Histidine kinase
M1L61_RS10480	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M1L61_RS10505	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M1L61_RS10510	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M1L61_RS10535	COG1987	bacterial-type flagellum assembly
M1L61_RS10545	COG3190	flagellar
M1L61_RS10595	COG1677	Flagellar hook-basal body complex protein FliE
M1L61_RS10615	COG2197	response regulator
M1L61_RS10635	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M1L61_RS10675	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M1L61_RS10685	COG4787	bacterial-type flagellum-dependent cell motility
M1L61_RS10700	COG1558	bacterial-type flagellum-dependent cell motility
M1L61_RS10705	COG1815	bacterial-type flagellum-dependent cell motility
M1L61_RS10710	COG0835	chemotaxis
M1L61_RS10710	COG0784	Response regulator, receiver
M1L61_RS10730	COG5002	protein histidine kinase activity
M1L61_RS10770	COG2915	High frequency lysogenization protein hflD homolog
M1L61_RS10775	COG0482	sulfurtransferase activity
M1L61_RS10790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1L61_RS10800	COG0542	response to heat
M1L61_RS10835	COG0492	ferredoxin-NADP+ reductase activity
M1L61_RS10840	COG1674	ftsk spoiiie
M1L61_RS10850	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1L61_RS10855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1L61_RS10870	COG2819	hydrolase of the alpha beta superfamily
M1L61_RS10880	COG4558	Periplasmic binding protein
M1L61_RS10885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1L61_RS10890	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M1L61_RS10900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M1L61_RS10915	COG0784	Response regulator, receiver
M1L61_RS10915	COG5002	protein histidine kinase activity
M1L61_RS10950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M1L61_RS10960	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
M1L61_RS10995	COG0784	Response regulator, receiver
M1L61_RS11000	COG4251	negative regulation of phosphorylation
M1L61_RS11010	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M1L61_RS11035	COG0789	Transcriptional regulator
M1L61_RS11040	COG2608	mercury ion transmembrane transporter activity
M1L61_RS11045	COG2608	mercury ion transmembrane transporter activity
M1L61_RS11055	COG0789	Transcriptional regulator
M1L61_RS11090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1L61_RS11115	COG0789	Transcriptional regulator
M1L61_RS11155	COG0789	Transcriptional regulator
M1L61_RS11160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1L61_RS11165	COG4644	lycopene metabolic process
M1L61_RS11200	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1L61_RS11210	COG2217	Heavy metal translocating P-type atpase
M1L61_RS11235	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1L61_RS11300	COG2132	Multicopper oxidase
M1L61_RS11325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M1L61_RS11380	COG4644	lycopene metabolic process
M1L61_RS11420	COG1902	pentaerythritol trinitrate reductase activity
M1L61_RS11435	COG1309	transcriptional regulator
M1L61_RS11570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M1L61_RS11575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1L61_RS11580	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M1L61_RS11585	COG2080	2 iron, 2 sulfur cluster binding
M1L61_RS11595	COG1764	response to oxidative stress
M1L61_RS11605	COG0583	DNA-binding transcription factor activity
M1L61_RS11625	COG1595	DNA-templated transcription, initiation
M1L61_RS11630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1L61_RS11710	COG3685	Protein conserved in bacteria
M1L61_RS11735	COG3546	catalase activity
M1L61_RS11740	COG3685	Protein conserved in bacteria
M1L61_RS11760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1L61_RS11780	COG1063	alcohol dehydrogenase
M1L61_RS11815	COG1609	Transcriptional regulator
M1L61_RS11820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1L61_RS11820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1L61_RS11825	COG1105	Belongs to the carbohydrate kinase PfkB family
M1L61_RS11830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1L61_RS11830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1L61_RS11850	COG2211	Major facilitator Superfamily
M1L61_RS11855	COG1472	Belongs to the glycosyl hydrolase 3 family
M1L61_RS11870	COG3661	Belongs to the glycosyl hydrolase 67 family
M1L61_RS11880	COG1472	Belongs to the glycosyl hydrolase 3 family
M1L61_RS11885	COG0477	Major facilitator Superfamily
M1L61_RS11895	COG1070	Carbohydrate kinase
M1L61_RS11920	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M1L61_RS11945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1L61_RS11960	COG2828	Protein conserved in bacteria
M1L61_RS11965	COG0583	DNA-binding transcription factor activity
M1L61_RS11975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1L61_RS11980	COG0583	DNA-binding transcription factor activity
M1L61_RS11995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M1L61_RS12030	COG0642	Histidine kinase
M1L61_RS12040	COG0318	PFAM AMP-dependent synthetase and ligase
M1L61_RS12050	COG5265	(ABC) transporter
M1L61_RS12095	COG2186	Transcriptional regulator
M1L61_RS12115	COG2271	Major facilitator Superfamily
M1L61_RS12120	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS12155	COG1404	Belongs to the peptidase S8 family
M1L61_RS12170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1L61_RS12185	COG2226	methyltransferase
M1L61_RS12195	COG0583	DNA-binding transcription factor activity
M1L61_RS12220	COG2204	response regulator
M1L61_RS12300	COG3447	MASE1 domain protein
M1L61_RS12300	COG5002	protein histidine kinase activity
M1L61_RS12300	COG5001	Diguanylate cyclase
M1L61_RS12305	COG1136	(ABC) transporter
M1L61_RS12305	COG0577	efflux transmembrane transporter activity
M1L61_RS12310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS12320	COG0745	RESPONSE REGULATOR receiver
M1L61_RS12325	COG2205	protein histidine kinase activity
M1L61_RS12335	COG3214	Protein conserved in bacteria
M1L61_RS12345	COG4774	siderophore transport
M1L61_RS12370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1L61_RS12375	COG1285	pathogenesis
M1L61_RS12380	COG4191	Histidine kinase
M1L61_RS12385	COG4566	intracellular signal transduction
M1L61_RS12455	COG0477	Major facilitator Superfamily
M1L61_RS12480	COG1136	(ABC) transporter
M1L61_RS12495	COG0583	DNA-binding transcription factor activity
M1L61_RS12525	COG1276	copper resistance
M1L61_RS12535	COG5002	protein histidine kinase activity
M1L61_RS12540	COG0583	DNA-binding transcription factor activity
M1L61_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS12575	COG0642	Histidine kinase
M1L61_RS12580	COG3537	Alpha-1,2-mannosidase
M1L61_RS12585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1L61_RS12600	COG0477	Major facilitator Superfamily
M1L61_RS12615	COG3920	Histidine kinase
M1L61_RS12615	COG2202	Pas domain
M1L61_RS12680	COG0811	peptide transport
M1L61_RS12815	COG0840	transmembrane signaling receptor activity
M1L61_RS12820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1L61_RS12830	COG4149	molybdate abc transporter
M1L61_RS12835	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1L61_RS12840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1L61_RS12855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1L61_RS12860	COG2181	nitrate reductase activity
M1L61_RS12865	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M1L61_RS12870	COG1140	nitrate reductase beta subunit
M1L61_RS12875	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M1L61_RS12880	COG2223	nitrite transmembrane transporter activity
M1L61_RS12890	COG0746	molybdenum cofactor guanylyltransferase activity
M1L61_RS12895	COG0314	molybdopterin synthase activity
M1L61_RS12905	COG0303	'Molybdopterin
M1L61_RS12910	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1L61_RS12910	COG0315	cyclic pyranopterin monophosphate synthase activity
M1L61_RS12915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1L61_RS12955	COG2207	Transcriptional regulator
M1L61_RS13010	COG2205	protein histidine kinase activity
M1L61_RS13020	COG2194	sulfuric ester hydrolase activity
M1L61_RS13040	COG2885	chlorophyll binding
M1L61_RS13060	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS13065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1L61_RS13065	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1L61_RS13070	COG1535	isochorismatase
M1L61_RS13070	COG3433	isochorismatase activity
M1L61_RS13075	COG1535	isochorismatase
M1L61_RS13075	COG3433	isochorismatase activity
M1L61_RS13080	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1L61_RS13095	COG2409	Drug exporters of the RND superfamily
M1L61_RS13100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1L61_RS13160	COG1914	H( )-stimulated, divalent metal cation uptake system
M1L61_RS13180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1L61_RS13185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1L61_RS13190	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS13190	COG3321	synthase
M1L61_RS13190	COG0604	alcohol dehydrogenase
M1L61_RS13195	COG4206	TonB-dependent receptor
M1L61_RS13200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1L61_RS13235	COG0583	DNA-binding transcription factor activity
M1L61_RS13245	COG4772	TonB-dependent receptor
M1L61_RS13265	COG2226	methyltransferase
M1L61_RS13310	COG4964	Belongs to the GSP D family
M1L61_RS13365	COG2814	Major facilitator Superfamily
M1L61_RS13375	COG1228	amidohydrolase
M1L61_RS13385	COG1335	isochorismatase
M1L61_RS13400	COG3850	Histidine kinase
M1L61_RS13405	COG2197	response regulator
M1L61_RS13410	COG2814	Major facilitator Superfamily
M1L61_RS13420	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1L61_RS13430	COG0583	DNA-binding transcription factor activity
M1L61_RS13445	COG3161	chorismate lyase activity
M1L61_RS13490	COG0277	FAD linked oxidase domain protein
M1L61_RS13495	COG1304	FMN binding
M1L61_RS13500	COG2186	Transcriptional regulator
M1L61_RS13510	COG1285	pathogenesis
M1L61_RS13535	COG2814	Major facilitator Superfamily
M1L61_RS13590	COG0587	DNA-directed DNA polymerase activity
M1L61_RS13610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M1L61_RS13615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1L61_RS13615	COG0519	Catalyzes the synthesis of GMP from XMP
M1L61_RS13630	COG1595	DNA-templated transcription, initiation
M1L61_RS13640	COG1629	transport
M1L61_RS13640	COG4206	TonB-dependent receptor
M1L61_RS13670	COG0531	amino acid
M1L61_RS13685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1L61_RS13695	COG0789	Transcriptional regulator
M1L61_RS13760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1L61_RS13790	COG3447	MASE1 domain protein
M1L61_RS13790	COG5001	Diguanylate cyclase
M1L61_RS13790	COG5002	protein histidine kinase activity
M1L61_RS13795	COG2183	response to ionizing radiation
M1L61_RS13820	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1L61_RS13840	COG0534	Mate efflux family protein
M1L61_RS13860	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M1L61_RS13870	COG0668	transmembrane transport
M1L61_RS13875	COG1902	pentaerythritol trinitrate reductase activity
M1L61_RS13885	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1L61_RS13895	COG1733	regulation of RNA biosynthetic process
M1L61_RS13900	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1L61_RS13905	COG0456	acetyltransferase
M1L61_RS13990	COG3702	type iv secretory pathway
M1L61_RS14010	COG2948	multi-organism process
M1L61_RS14020	COG3736	Type IV secretory pathway, component VirB8
M1L61_RS14040	COG2814	Major facilitator Superfamily
M1L61_RS14045	COG0789	Transcriptional regulator
M1L61_RS14095	COG4774	siderophore transport
M1L61_RS14105	COG0745	RESPONSE REGULATOR receiver
M1L61_RS14125	COG1136	(ABC) transporter
M1L61_RS14125	COG0577	efflux transmembrane transporter activity
M1L61_RS14145	COG1733	regulation of RNA biosynthetic process
M1L61_RS14150	COG0604	alcohol dehydrogenase
M1L61_RS14160	COG0210	DNA helicase
M1L61_RS14170	COG0582	viral genome integration into host DNA
M1L61_RS14260	COG0583	DNA-binding transcription factor activity
M1L61_RS14265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1L61_RS14275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M1L61_RS14290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1L61_RS14295	COG0077	Prephenate dehydratase
M1L61_RS14295	COG1605	Chorismate mutase
M1L61_RS14300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M1L61_RS14335	COG1228	amidohydrolase
M1L61_RS14350	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M1L61_RS14405	COG2957	Belongs to the agmatine deiminase family
M1L61_RS14410	COG0583	DNA-binding transcription factor activity
M1L61_RS14470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M1L61_RS14480	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1L61_RS14490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M1L61_RS14495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M1L61_RS14510	COG0359	binds to the 23S rRNA
M1L61_RS14515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M1L61_RS14520	COG0360	Binds together with S18 to 16S ribosomal RNA
M1L61_RS14525	COG0316	Belongs to the HesB IscA family
M1L61_RS14530	COG0017	Asparaginyl-tRNA synthetase
M1L61_RS14550	COG0288	reversible hydration of carbon dioxide
M1L61_RS14560	COG3844	kynureninase activity
M1L61_RS14565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1L61_RS14570	COG2925	Exonuclease
M1L61_RS14580	COG0667	Aldo Keto reductase
M1L61_RS14600	COG2902	Dehydrogenase
M1L61_RS14610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS14615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1L61_RS14625	COG1960	acyl-CoA dehydrogenase activity
M1L61_RS14640	COG0646	methionine synthase
M1L61_RS14640	COG1410	methionine synthase
M1L61_RS14655	COG2900	Belongs to the SlyX family
M1L61_RS14670	COG0386	Belongs to the glutathione peroxidase family
M1L61_RS14675	COG1725	Transcriptional regulator
M1L61_RS14680	COG1131	(ABC) transporter
M1L61_RS14715	COG2850	peptidyl-arginine hydroxylation
M1L61_RS14725	COG0567	Dehydrogenase, E1 component
M1L61_RS14750	COG3540	Alkaline phosphatase
M1L61_RS14760	COG0305	Participates in initiation and elongation during chromosome replication
M1L61_RS14780	COG0625	glutathione transferase activity
M1L61_RS14800	COG0084	hydrolase, TatD family'
M1L61_RS14805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1L61_RS14840	COG0625	glutathione transferase activity
M1L61_RS14860	COG1595	DNA-templated transcription, initiation
M1L61_RS14865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1L61_RS14880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1L61_RS14885	COG0386	Belongs to the glutathione peroxidase family
M1L61_RS14890	COG0339	signal peptide processing
M1L61_RS14895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M1L61_RS14915	COG0705	Rhomboid family
M1L61_RS14920	COG3104	oligopeptide transport
M1L61_RS14930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1L61_RS14935	COG4290	ribonuclease
M1L61_RS14950	COG0316	Belongs to the HesB IscA family
M1L61_RS14950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M1L61_RS14955	COG2154	pterin-4-alpha-carbinolamine dehydratase
M1L61_RS14965	COG0428	transporter
M1L61_RS14975	COG1530	ribonuclease E activity
M1L61_RS14990	COG0395	ABC-type sugar transport system, permease component
M1L61_RS15015	COG1609	Transcriptional regulator
M1L61_RS15020	COG0271	Belongs to the BolA IbaG family
M1L61_RS15025	COG2350	Protein conserved in bacteria
M1L61_RS15030	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1L61_RS15035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1L61_RS15040	COG1187	pseudouridine synthase activity
M1L61_RS15050	COG2814	Major facilitator Superfamily
M1L61_RS15070	COG0436	Aminotransferase
M1L61_RS15075	COG4133	protoheme IX ABC transporter activity
M1L61_RS15095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M1L61_RS15110	COG4235	cytochrome complex assembly
M1L61_RS15110	COG3088	subunit of a heme lyase
M1L61_RS15120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1L61_RS15130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M1L61_RS15135	COG4988	ABC transporter
M1L61_RS15145	COG1294	oxidase, subunit
M1L61_RS15175	COG0726	polysaccharide deacetylase
M1L61_RS15175	COG1649	PFAM Uncharacterised BCR, COG1649
M1L61_RS15180	COG1215	transferase activity, transferring glycosyl groups
M1L61_RS15190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M1L61_RS15205	COG0165	Argininosuccinate lyase
M1L61_RS15210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M1L61_RS15220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M1L61_RS15225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1L61_RS15230	COG0137	argininosuccinate synthase activity
M1L61_RS15235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M1L61_RS15250	COG2166	iron-sulfur cluster assembly
M1L61_RS15270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M1L61_RS15290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1L61_RS15295	COG0402	S-adenosylhomocysteine deaminase activity
M1L61_RS15300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M1L61_RS15305	COG1509	lysine 2,3-aminomutase activity
M1L61_RS15310	COG5001	Diguanylate cyclase
M1L61_RS15310	COG3300	MHYT domain
M1L61_RS15330	COG0501	Belongs to the peptidase M48B family
M1L61_RS15340	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS15360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1L61_RS15365	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1L61_RS15370	COG0802	atpase or kinase
M1L61_RS15375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1L61_RS15375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1L61_RS15380	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1L61_RS15385	COG1570	exodeoxyribonuclease VII activity
M1L61_RS15395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1L61_RS15415	COG4771	TonB-dependent receptor
M1L61_RS15420	COG1309	transcriptional regulator
M1L61_RS15460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1L61_RS15460	COG2169	Transcriptional regulator
M1L61_RS15465	COG2130	NADP-dependent
M1L61_RS15490	COG1960	acyl-CoA dehydrogenase activity
M1L61_RS15500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M1L61_RS15530	COG1309	transcriptional regulator
M1L61_RS15535	COG2076	Multidrug Resistance protein
M1L61_RS15540	COG5487	UPF0391 membrane protein
M1L61_RS15545	COG1280	lysine exporter protein (LysE YggA)
M1L61_RS15550	COG0740	serine-type endopeptidase activity
M1L61_RS15565	COG1794	racemase activity, acting on amino acids and derivatives
M1L61_RS15585	COG0454	-acetyltransferase
M1L61_RS15585	COG0456	acetyltransferase
M1L61_RS15600	COG0776	regulation of translation
M1L61_RS15605	COG0072	phenylalanine-tRNA ligase activity
M1L61_RS15605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1L61_RS15610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M1L61_RS15615	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M1L61_RS15620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M1L61_RS15625	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M1L61_RS15630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1L61_RS15660	COG1185	polyribonucleotide nucleotidyltransferase activity
M1L61_RS15665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M1L61_RS15670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1L61_RS15675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M1L61_RS15680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M1L61_RS15685	COG0195	Participates in both transcription termination and antitermination
M1L61_RS15690	COG0779	Required for maturation of 30S ribosomal subunits
M1L61_RS15705	COG1007	ATP synthesis coupled electron transport
M1L61_RS15720	COG0713	ATP synthesis coupled electron transport
M1L61_RS15730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1L61_RS15735	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M1L61_RS15750	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M1L61_RS15755	COG0649	NAD binding
M1L61_RS15760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1L61_RS15765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1L61_RS15770	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1L61_RS15785	COG0149	triose-phosphate isomerase activity
M1L61_RS15795	COG3119	arylsulfatase activity
M1L61_RS15800	COG0438	transferase activity, transferring glycosyl groups
M1L61_RS15805	COG0726	polysaccharide deacetylase
M1L61_RS15810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1L61_RS15815	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M1L61_RS15820	COG0159	tryptophan synthase activity
M1L61_RS15830	COG0133	tryptophan synthase activity
M1L61_RS15840	COG0860	N-Acetylmuramoyl-L-alanine amidase
M1L61_RS15840	COG3409	Peptidoglycan-binding domain 1 protein
M1L61_RS15850	COG0135	phosphoribosylanthranilate isomerase activity
M1L61_RS15855	COG0101	tRNA pseudouridine synthase activity
M1L61_RS15870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M1L61_RS15875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M1L61_RS15880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M1L61_RS15885	COG2890	protein-(glutamine-N5) methyltransferase activity
M1L61_RS15890	COG1999	signal sequence binding
M1L61_RS15895	COG0688	phosphatidylethanolamine metabolic process
M1L61_RS15910	COG0433	COG0433 Predicted ATPase
M1L61_RS15915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1L61_RS15925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1L61_RS15930	COG0412	Dienelactone hydrolase
M1L61_RS15945	COG0717	Belongs to the dCTP deaminase family
M1L61_RS15950	COG0489	protein tyrosine kinase activity
M1L61_RS15955	COG4771	TonB-dependent receptor
M1L61_RS15960	COG4771	TonB-dependent receptor
M1L61_RS15970	COG4771	TonB-dependent receptor
M1L61_RS15975	COG3590	peptidase
M1L61_RS16005	COG0697	spore germination
M1L61_RS16015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1L61_RS16020	COG2311	Membrane
M1L61_RS16025	COG1047	Peptidyl-prolyl cis-trans
M1L61_RS16030	COG0791	NLP P60 protein
M1L61_RS16035	COG0791	NLP P60 protein
M1L61_RS16040	COG1301	dicarboxylic acid transport
M1L61_RS16060	COG1722	exodeoxyribonuclease VII activity
M1L61_RS16065	COG0142	geranyltranstransferase activity
M1L61_RS16075	COG0312	modulator of DNA gyrase
M1L61_RS16080	COG3028	Belongs to the UPF0307 family
M1L61_RS16085	COG0312	modulator of DNA gyrase
M1L61_RS16105	COG2968	Membrane
M1L61_RS16115	COG4771	TonB-dependent receptor
M1L61_RS16130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M1L61_RS16140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M1L61_RS16155	COG0495	leucyl-tRNA aminoacylation
M1L61_RS16165	COG3118	belongs to the thioredoxin family
M1L61_RS16175	COG2203	Gaf domain
M1L61_RS16175	COG3706	GGDEF domain
M1L61_RS16175	COG4251	negative regulation of phosphorylation
M1L61_RS16175	COG5001	Diguanylate cyclase
M1L61_RS16200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M1L61_RS16210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1L61_RS16215	COG0346	lactoylglutathione lyase activity
M1L61_RS16225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1L61_RS16225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1L61_RS16235	COG2878	Part of a membrane complex involved in electron transport
M1L61_RS16240	COG0251	oxidation-reduction process
M1L61_RS16245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M1L61_RS16245	COG0392	lysyltransferase activity
M1L61_RS16275	COG2824	Alkylphosphonate utilization operon protein PhnA
M1L61_RS16280	COG0443	Heat shock 70 kDa protein
M1L61_RS16320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1L61_RS16325	COG3122	Protein conserved in bacteria
M1L61_RS16330	COG1451	nucleotide metabolic process
M1L61_RS16340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1L61_RS16360	COG0183	Belongs to the thiolase family
M1L61_RS16375	COG1960	acyl-CoA dehydrogenase activity
M1L61_RS16385	COG1793	dna ligase
M1L61_RS16390	COG1201	RNA secondary structure unwinding
M1L61_RS16405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1L61_RS16410	COG1278	Cold shock
M1L61_RS16415	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M1L61_RS16420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M1L61_RS16425	COG1472	Belongs to the glycosyl hydrolase 3 family
M1L61_RS16430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1L61_RS16435	COG2954	triphosphatase activity
M1L61_RS16440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M1L61_RS16445	COG0745	RESPONSE REGULATOR receiver
M1L61_RS16455	COG1381	Involved in DNA repair and RecF pathway recombination
M1L61_RS16460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1L61_RS16475	COG0681	Belongs to the peptidase S26 family
M1L61_RS16480	COG0481	GTPase activity
M1L61_RS16485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1L61_RS16505	COG1741	Belongs to the pirin family
M1L61_RS16510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M1L61_RS16520	COG1741	Belongs to the pirin family
M1L61_RS16525	COG1966	Carbon starvation protein
M1L61_RS16530	COG2879	small protein
M1L61_RS16545	COG2205	protein histidine kinase activity
M1L61_RS16550	COG0745	RESPONSE REGULATOR receiver
M1L61_RS16585	COG2814	Major facilitator Superfamily
M1L61_RS16590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M1L61_RS16590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M1L61_RS16600	COG1113	amino acid transport
M1L61_RS16605	COG2207	Transcriptional regulator
M1L61_RS16605	COG1917	Cupin 2, conserved barrel domain protein
M1L61_RS16610	COG0753	catalase activity
M1L61_RS16625	COG1376	ErfK ybiS ycfS ynhG family protein
M1L61_RS16630	COG0739	heme binding
M1L61_RS16640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1L61_RS16650	COG0330	HflC and HflK could
M1L61_RS16655	COG0330	HflC and HflK could
M1L61_RS16660	COG0604	alcohol dehydrogenase
M1L61_RS16675	COG0678	peroxiredoxin activity
M1L61_RS16685	COG4953	penicillin-binding protein 1C
M1L61_RS16690	COG2373	Large extracellular alpha-helical protein
M1L61_RS16695	COG2079	MmgE PrpD family protein
M1L61_RS16700	COG2828	Protein conserved in bacteria
M1L61_RS16710	COG3609	addiction module antidote protein, CC2985 family
M1L61_RS16730	COG3829	transcription factor binding
M1L61_RS16735	COG0259	pyridoxamine-phosphate oxidase activity
M1L61_RS16750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M1L61_RS16770	COG0477	Major facilitator Superfamily
M1L61_RS16780	COG2198	Histidine kinase
M1L61_RS16780	COG5002	protein histidine kinase activity
M1L61_RS16780	COG0784	Response regulator, receiver
M1L61_RS16785	COG5002	protein histidine kinase activity
M1L61_RS16785	COG0784	Response regulator, receiver
M1L61_RS16795	COG3038	cytochrome b561
M1L61_RS16810	COG1760	l-serine dehydratase
M1L61_RS16815	COG2267	carboxylic ester hydrolase activity
M1L61_RS16820	COG0460	homoserine dehydrogenase
M1L61_RS16820	COG0527	aspartate kinase activity
M1L61_RS16825	COG0626	cystathionine gamma-synthase activity
M1L61_RS16830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1L61_RS16835	COG0739	heme binding
M1L61_RS16840	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1L61_RS16845	COG1272	protein, Hemolysin III
M1L61_RS16850	COG2982	Protein involved in outer membrane biogenesis
M1L61_RS16860	COG0463	Glycosyl transferase, family 2
M1L61_RS16865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1L61_RS16870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1L61_RS16885	COG1309	transcriptional regulator
M1L61_RS16925	COG0583	DNA-binding transcription factor activity
M1L61_RS16940	COG0509	glycine decarboxylation via glycine cleavage system
M1L61_RS16945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M1L61_RS16955	COG0330	HflC and HflK could
M1L61_RS16965	COG1742	UPF0060 membrane protein
M1L61_RS16970	COG3956	TIGRFAM MazG family protein
M1L61_RS16975	COG1218	3'(2'),5'-bisphosphate nucleotidase
M1L61_RS16980	COG0494	nUDIX hydrolase
M1L61_RS16990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1L61_RS17005	COG2198	Histidine kinase
M1L61_RS17005	COG0784	Response regulator, receiver
M1L61_RS17005	COG0643	Histidine kinase
M1L61_RS17010	COG0840	transmembrane signaling receptor activity
M1L61_RS17015	COG0835	chemotaxis
M1L61_RS17030	COG0189	ligase activity
M1L61_RS17040	COG1214	PFAM Peptidase M22, glycoprotease
M1L61_RS17045	COG1199	ATP-dependent helicase activity
M1L61_RS17055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1L61_RS17065	COG1215	transferase activity, transferring glycosyl groups
M1L61_RS17075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1L61_RS17085	COG1643	Atp-dependent helicase
M1L61_RS17090	COG0783	Belongs to the Dps family
M1L61_RS17095	COG0514	ATP-dependent DNA helicase (RecQ)
M1L61_RS17445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1L61_RS17450	COG0602	queuosine metabolic process
M1L61_RS17460	COG2885	chlorophyll binding
M1L61_RS17465	COG0823	Involved in the tonB-independent uptake of proteins
M1L61_RS17480	COG0811	peptide transport
M1L61_RS17485	COG0824	Thioesterase
M1L61_RS17490	COG2255	four-way junction helicase activity
M1L61_RS17500	COG0632	four-way junction helicase activity
M1L61_RS17505	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M1L61_RS17510	COG0217	transcriptional regulatory protein
M1L61_RS17530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M1L61_RS17560	COG0488	(ABC) transporter
M1L61_RS17570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1L61_RS17570	COG4651	solute:proton antiporter activity
M1L61_RS17580	COG0745	RESPONSE REGULATOR receiver
M1L61_RS17585	COG2205	protein histidine kinase activity
M1L61_RS17595	COG0542	response to heat
M1L61_RS17620	COG0028	Belongs to the TPP enzyme family
M1L61_RS17645	COG3387	PFAM Glycoside hydrolase 15-related
M1L61_RS17650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1L61_RS17655	COG3011	Protein conserved in bacteria
M1L61_RS17670	COG0564	pseudouridine synthase activity
M1L61_RS17675	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1L61_RS17685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1L61_RS17685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1L61_RS17695	COG0045	succinate-CoA ligase (ADP-forming) activity
M1L61_RS17725	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1L61_RS17740	COG2205	protein histidine kinase activity
M1L61_RS17745	COG0745	RESPONSE REGULATOR receiver
M1L61_RS17760	COG0189	ligase activity
M1L61_RS17780	COG3152	Membrane
M1L61_RS17860	COG0583	DNA-binding transcription factor activity
M1L61_RS17870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1L61_RS17895	COG1120	ATPase activity
M1L61_RS17950	COG2003	Belongs to the UPF0758 family
M1L61_RS18050	COG3039	Transposase
M1L61_RS18135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1L61_RS18140	COG0629	single-stranded DNA binding
M1L61_RS18190	COG0582	viral genome integration into host DNA
M1L61_RS18200	COG3240	lipase activity
M1L61_RS18200	COG4625	pathogenesis
M1L61_RS18210	COG2022	thiamine diphosphate biosynthetic process
M1L61_RS18215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1L61_RS18220	COG0471	metal ion transport
M1L61_RS18220	COG3273	potassium ion transport
M1L61_RS18240	COG1970	mechanosensitive ion channel activity
M1L61_RS18255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1L61_RS18260	COG1115	amino acid carrier protein
M1L61_RS18265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1L61_RS18270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1L61_RS18275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS18300	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M1L61_RS18310	COG3588	fructose-bisphosphate aldolase
M1L61_RS18315	COG0469	pyruvate kinase activity
M1L61_RS18325	COG0126	phosphoglycerate kinase activity
M1L61_RS18345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1L61_RS18350	COG3047	cAMP biosynthetic process
M1L61_RS18390	COG3093	addiction module antidote protein HigA
M1L61_RS18400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1L61_RS18405	COG1301	dicarboxylic acid transport
M1L61_RS18415	COG2304	oxidoreductase activity
M1L61_RS18435	COG0714	Associated with various cellular activities
M1L61_RS18465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M1L61_RS18520	COG0254	rRNA binding
M1L61_RS18530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1L61_RS18540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1L61_RS18545	COG1758	RNA polymerase activity
M1L61_RS18560	COG0437	4 iron, 4 sulfur cluster binding
M1L61_RS18565	COG2864	formate dehydrogenase
M1L61_RS18580	COG1921	L-seryl-tRNASec selenium transferase activity
M1L61_RS18585	COG3276	selenocysteine insertion sequence binding
M1L61_RS18595	COG0709	Synthesizes selenophosphate from selenide and ATP
M1L61_RS18600	COG1561	YicC-like family, N-terminal region
M1L61_RS18605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M1L61_RS18610	COG0346	lactoylglutathione lyase activity
M1L61_RS18620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1L61_RS18635	COG0006	proline dipeptidase activity
M1L61_RS18645	COG0006	proline dipeptidase activity
M1L61_RS18650	COG3079	Belongs to the UPF0149 family
M1L61_RS18670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1L61_RS18680	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M1L61_RS18690	COG2912	Transglutaminase-like superfamily
M1L61_RS18695	COG1773	rubredoxin
M1L61_RS18705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M1L61_RS18710	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M1L61_RS18720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1L61_RS18725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1L61_RS18735	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS18760	COG0671	phosphoesterase, PA-phosphatase related
M1L61_RS18770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1L61_RS18775	COG0563	adenylate kinase activity
M1L61_RS18800	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M1L61_RS18810	COG0848	biopolymer transport protein
M1L61_RS18820	COG2832	Protein of unknown function (DUF454)
M1L61_RS18905	COG4397	Mu-like prophage major head subunit gpT
M1L61_RS18930	COG4383	Mu-like prophage protein gp29
M1L61_RS18935	COG4373	Mu-like prophage FluMu protein gp28
M1L61_RS18960	COG0739	heme binding
M1L61_RS18960	COG0741	lytic transglycosylase activity
M1L61_RS18960	COG1196	nuclear chromosome segregation
M1L61_RS18975	COG5566	PFAM Mor transcription activator
M1L61_RS19060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1L61_RS19080	COG0745	RESPONSE REGULATOR receiver
M1L61_RS19090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M1L61_RS19095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1L61_RS19100	COG0405	Gamma-glutamyltransferase
M1L61_RS19105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1L61_RS19125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1L61_RS19130	COG2226	methyltransferase
M1L61_RS19145	COG0473	3-isopropylmalate dehydrogenase activity
M1L61_RS19160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1L61_RS19165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS19180	COG1538	Outer membrane efflux protein
M1L61_RS19185	COG0531	amino acid
M1L61_RS19190	COG1519	Transferase
M1L61_RS19195	COG1560	Kdo2-lipid A biosynthetic process
M1L61_RS19235	COG1301	dicarboxylic acid transport
M1L61_RS19245	COG4191	Histidine kinase
M1L61_RS19265	COG0642	Histidine kinase
M1L61_RS19280	COG2851	Citrate transporter
M1L61_RS19285	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS19305	COG1162	GTPase activity
M1L61_RS19310	COG0436	Aminotransferase
M1L61_RS19330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1L61_RS19345	COG1228	amidohydrolase
M1L61_RS19350	COG0804	urea catabolic process
M1L61_RS19360	COG1307	EDD domain protein, DegV family
M1L61_RS19405	COG5001	Diguanylate cyclase
M1L61_RS19405	COG4251	negative regulation of phosphorylation
M1L61_RS19405	COG3706	GGDEF domain
M1L61_RS19405	COG2203	Gaf domain
M1L61_RS19410	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1L61_RS19420	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1L61_RS19430	COG4206	TonB-dependent receptor
M1L61_RS19440	COG1902	pentaerythritol trinitrate reductase activity
M1L61_RS19465	COG0583	DNA-binding transcription factor activity
M1L61_RS19470	COG1064	alcohol dehydrogenase
M1L61_RS19490	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M1L61_RS19495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M1L61_RS19510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1L61_RS19525	COG1522	sequence-specific DNA binding
M1L61_RS19535	COG4773	Receptor
M1L61_RS19560	COG0617	tRNA 3'-terminal CCA addition
M1L61_RS19585	COG3468	outer membrane autotransporter barrel domain protein
M1L61_RS19595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M1L61_RS19600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1L61_RS19605	COG1609	Transcriptional regulator
M1L61_RS19615	COG0837	glucose binding
M1L61_RS19625	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M1L61_RS19645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1L61_RS19655	COG4191	Histidine kinase
M1L61_RS19660	COG0784	Response regulator, receiver
M1L61_RS19665	COG4251	negative regulation of phosphorylation
M1L61_RS19670	COG2823	Periplasmic or secreted lipoprotein
M1L61_RS19675	COG0673	inositol 2-dehydrogenase activity
M1L61_RS19680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M1L61_RS19700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1L61_RS19705	COG0321	lipoyl(octanoyl) transferase activity
M1L61_RS19710	COG2921	Belongs to the UPF0250 family
M1L61_RS19720	COG1686	Belongs to the peptidase S11 family
M1L61_RS19725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1L61_RS19730	COG2951	lytic endotransglycosylase activity
M1L61_RS19735	COG0772	Belongs to the SEDS family
M1L61_RS19740	COG0772	Belongs to the SEDS family
M1L61_RS19745	COG0768	penicillin binding
M1L61_RS19755	COG1792	Involved in formation and maintenance of cell shape
M1L61_RS19760	COG1077	Cell shape determining protein MreB Mrl
M1L61_RS19765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1L61_RS19780	COG0308	aminopeptidase N
M1L61_RS19785	COG2226	methyltransferase
M1L61_RS19815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1L61_RS19820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS19830	COG0673	inositol 2-dehydrogenase activity
M1L61_RS19840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M1L61_RS19860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M1L61_RS19870	COG2832	Protein of unknown function (DUF454)
M1L61_RS19880	COG0436	Aminotransferase
M1L61_RS19885	COG1505	serine-type exopeptidase activity
M1L61_RS19910	COG0697	spore germination
M1L61_RS19915	COG1666	GTP binding
M1L61_RS19945	COG0339	signal peptide processing
M1L61_RS19955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1L61_RS19975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1L61_RS19985	COG1136	(ABC) transporter
M1L61_RS19990	COG1136	(ABC) transporter
M1L61_RS19990	COG0577	efflux transmembrane transporter activity
M1L61_RS19995	COG0577	efflux transmembrane transporter activity
M1L61_RS20005	COG2204	response regulator
M1L61_RS20010	COG4191	Histidine kinase
M1L61_RS20020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M1L61_RS20030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M1L61_RS20035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M1L61_RS20040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M1L61_RS20045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M1L61_RS20050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M1L61_RS20055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M1L61_RS20065	COG0356	it plays a direct role in the translocation of protons across the membrane
M1L61_RS20080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1L61_RS20085	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1L61_RS20105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1L61_RS20130	COG0181	hydroxymethylbilane synthase activity
M1L61_RS20140	COG0745	RESPONSE REGULATOR receiver
M1L61_RS20140	COG2972	Histidine kinase
M1L61_RS20155	COG4771	TonB-dependent receptor
M1L61_RS20170	COG0840	transmembrane signaling receptor activity
M1L61_RS20240	COG0583	DNA-binding transcription factor activity
M1L61_RS20245	COG0477	Major facilitator Superfamily
M1L61_RS20280	COG0625	glutathione transferase activity
M1L61_RS20285	COG2259	Doxx family
M1L61_RS20325	COG2135	peptidase activity
M1L61_RS20345	COG4695	Portal protein
M1L61_RS20390	COG3179	chitinase
M1L61_RS20515	COG3657	addiction module killer protein
M1L61_RS20570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M1L61_RS20575	COG1490	D-aminoacyl-tRNA deacylase activity
M1L61_RS20620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M1L61_RS20620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M1L61_RS20625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M1L61_RS20630	COG0242	peptide deformylase activity
M1L61_RS20640	COG0758	DNA mediated transformation
M1L61_RS20645	COG2922	Belongs to the Smg family
M1L61_RS20655	COG1714	RDD family
M1L61_RS20660	COG1754	DNA topoisomerase type I activity
M1L61_RS20660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1L61_RS20665	COG0009	L-threonylcarbamoyladenylate synthase
M1L61_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS20690	COG0616	signal peptide processing
M1L61_RS20695	COG0534	Mate efflux family protein
M1L61_RS20710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1L61_RS20715	COG0625	glutathione transferase activity
M1L61_RS20725	COG1252	NADH dehydrogenase
M1L61_RS20740	COG2860	membrane
M1L61_RS20750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1L61_RS20770	COG1846	Transcriptional regulator
M1L61_RS20800	COG0459	protein refolding
M1L61_RS20805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M1L61_RS20810	COG2356	endonuclease I
M1L61_RS20815	COG1324	tolerance protein
M1L61_RS20825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1L61_RS20835	COG0840	transmembrane signaling receptor activity
M1L61_RS20855	COG4585	Histidine kinase
M1L61_RS20875	COG0583	DNA-binding transcription factor activity
M1L61_RS20890	COG1785	Belongs to the alkaline phosphatase family
M1L61_RS20895	COG1686	Belongs to the peptidase S11 family
M1L61_RS20905	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1L61_RS20915	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M1L61_RS20925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M1L61_RS20935	COG0511	ligase activity, forming carbon-carbon bonds
M1L61_RS20940	COG0439	Biotin carboxylase
M1L61_RS20955	COG2264	protein methyltransferase activity
M1L61_RS20965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1L61_RS20970	COG4589	Belongs to the CDS family
M1L61_RS20985	COG0671	phosphoesterase, PA-phosphatase related
M1L61_RS20985	COG2453	phosphatase
M1L61_RS20990	COG2267	carboxylic ester hydrolase activity
M1L61_RS20995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1L61_RS21000	COG0138	bifunctional purine biosynthesis protein purh
M1L61_RS21010	COG0151	Belongs to the GarS family
M1L61_RS21025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M1L61_RS21030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M1L61_RS21035	COG2201	protein-glutamate methylesterase activity
M1L61_RS21040	COG2177	Part of the ABC transporter FtsEX involved in
M1L61_RS21045	COG2884	Cell division ATP-binding protein ftsE
M1L61_RS21055	COG3118	belongs to the thioredoxin family
M1L61_RS21060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M1L61_RS21065	COG3706	GGDEF domain
M1L61_RS21075	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M1L61_RS21110	COG1652	LysM domain
M1L61_RS21115	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M1L61_RS21115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M1L61_RS21120	COG1473	amidohydrolase
M1L61_RS21125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS21130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1L61_RS21140	COG1289	transmembrane transporter activity
M1L61_RS21145	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS21150	COG2814	Major facilitator Superfamily
M1L61_RS21180	COG0316	Belongs to the HesB IscA family
M1L61_RS21205	COG5002	protein histidine kinase activity
M1L61_RS21205	COG2205	protein histidine kinase activity
M1L61_RS21205	COG0784	Response regulator, receiver
M1L61_RS21225	COG1051	belongs to the nudix hydrolase family
M1L61_RS21240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1L61_RS21245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M1L61_RS21250	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M1L61_RS21260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M1L61_RS21265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1L61_RS21270	COG0730	response to heat
M1L61_RS21280	COG0134	indole-3-glycerol-phosphate synthase activity
M1L61_RS21285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1L61_RS21320	COG1597	lipid kinase activity
M1L61_RS21335	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M1L61_RS21340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M1L61_RS21350	COG2111	Na H antiporter
M1L61_RS21350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1L61_RS21355	COG1006	Multisubunit Na H antiporter MnhC subunit
M1L61_RS21360	COG0651	ATP synthesis coupled electron transport
M1L61_RS21365	COG1863	multisubunit Na H antiporter MnhE subunit
M1L61_RS21370	COG2212	antiporter activity
M1L61_RS21375	COG1320	monovalent cation:proton antiporter activity
M1L61_RS21380	COG0530	calcium, potassium:sodium antiporter activity
M1L61_RS21395	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M1L61_RS21420	COG3104	oligopeptide transport
M1L61_RS21425	COG3483	tryptophan 2,3-dioxygenase activity
M1L61_RS21455	COG2378	regulation of single-species biofilm formation
M1L61_RS21470	COG2354	Protein conserved in bacteria
M1L61_RS21475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1L61_RS21480	COG1368	sulfuric ester hydrolase activity
M1L61_RS21485	COG3264	Mechanosensitive ion channel
M1L61_RS21485	COG1511	domain protein
M1L61_RS21505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M1L61_RS21540	COG1166	arginine decarboxylase activity
M1L61_RS21545	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M1L61_RS21565	COG2960	long-chain fatty acid transporting porin activity
M1L61_RS21630	COG2161	toxin-antitoxin pair type II binding
M1L61_RS21650	COG0606	chelatase, subunit chli
M1L61_RS21670	COG0561	phosphatase activity
M1L61_RS21675	COG3932	Exopolysaccharide synthesis, ExoD
M1L61_RS21700	COG1999	signal sequence binding
M1L61_RS21705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1L61_RS21710	COG1845	cytochrome c oxidase, subunit III
M1L61_RS21720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1L61_RS21725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1L61_RS21740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1L61_RS21770	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1L61_RS21795	COG2031	fatty acid transporter
M1L61_RS21830	COG0673	inositol 2-dehydrogenase activity
M1L61_RS21840	COG1501	Belongs to the glycosyl hydrolase 31 family
M1L61_RS21845	COG2222	sugar isomerase
M1L61_RS21850	COG1940	carbohydrate kinase activity
M1L61_RS21860	COG1349	DNA-binding transcription factor activity
M1L61_RS21865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M1L61_RS21870	COG2814	Major facilitator Superfamily
M1L61_RS21885	COG1040	competence protein
M1L61_RS21905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M1L61_RS21910	COG0156	8-amino-7-oxononanoate synthase activity
M1L61_RS21915	COG2267	carboxylic ester hydrolase activity
M1L61_RS21920	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS21935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1L61_RS21955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1L61_RS21960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1L61_RS21965	COG2205	protein histidine kinase activity
M1L61_RS21970	COG0745	RESPONSE REGULATOR receiver
M1L61_RS21975	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1L61_RS22000	COG0714	Associated with various cellular activities
M1L61_RS22015	COG0754	glutathionylspermidine amidase activity
M1L61_RS22025	COG0129	dihydroxy-acid dehydratase activity
M1L61_RS22035	COG1199	ATP-dependent helicase activity
M1L61_RS22045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M1L61_RS22065	COG3781	membrane
M1L61_RS22085	COG3291	Pkd domain containing protein
M1L61_RS22105	COG0625	glutathione transferase activity
M1L61_RS22125	COG2207	Transcriptional regulator
M1L61_RS22140	COG4555	ABC transporter
M1L61_RS22170	COG0543	2 iron, 2 sulfur cluster binding
M1L61_RS22170	COG0633	Ferredoxin
M1L61_RS22175	COG1131	(ABC) transporter
M1L61_RS22180	COG0842	Transport permease protein
M1L61_RS22190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M1L61_RS22200	COG0084	hydrolase, TatD family'
M1L61_RS22205	COG1643	Atp-dependent helicase
M1L61_RS22215	COG1187	pseudouridine synthase activity
M1L61_RS22230	COG0667	Aldo Keto reductase
M1L61_RS22245	COG1690	Belongs to the RtcB family
M1L61_RS22255	COG1959	2 iron, 2 sulfur cluster binding
M1L61_RS22265	COG0583	DNA-binding transcription factor activity
M1L61_RS22270	COG2814	Major facilitator Superfamily
M1L61_RS22275	COG0656	L-ascorbic acid biosynthetic process
M1L61_RS22280	COG2205	protein histidine kinase activity
M1L61_RS22280	COG2198	Histidine kinase
M1L61_RS22280	COG0784	Response regulator, receiver
M1L61_RS22295	COG2267	carboxylic ester hydrolase activity
M1L61_RS22300	COG0393	Putative heavy-metal-binding
M1L61_RS22305	COG1042	CoA-binding domain protein
M1L61_RS22305	COG0045	succinate-CoA ligase (ADP-forming) activity
M1L61_RS22305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1L61_RS22310	COG2239	Acts as a magnesium transporter
M1L61_RS22325	COG3100	YcgL domain-containing protein
M1L61_RS22340	COG1028	Short-chain dehydrogenase reductase Sdr
M1L61_RS22360	COG0644	oxidoreductase
M1L61_RS22380	COG2986	histidine ammonia-lyase
M1L61_RS22390	COG0463	Glycosyl transferase, family 2
M1L61_RS22405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1L61_RS22410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1L61_RS22425	COG1294	oxidase, subunit
M1L61_RS22430	COG1271	oxidase subunit
M1L61_RS22465	COG1595	DNA-templated transcription, initiation
M1L61_RS22480	COG0494	nUDIX hydrolase
M1L61_RS22500	COG0408	coproporphyrinogen oxidase activity
M1L61_RS22510	COG2323	membrane
M1L61_RS22525	COG0589	response to stress
M1L61_RS22545	COG0210	DNA helicase
M1L61_RS22555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1L61_RS22560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M1L61_RS22565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M1L61_RS22580	COG0251	oxidation-reduction process
M1L61_RS22615	COG0463	Glycosyl transferase, family 2
M1L61_RS22630	COG1475	DNA binding
M1L61_RS22635	COG1192	Involved in chromosome partitioning
M1L61_RS22640	COG0357	Ribosomal RNA small subunit methyltransferase G
M1L61_RS22645	COG2091	lysine biosynthetic process via aminoadipic acid
M1L61_RS22685	COG1943	Transposase
M1L61_RS22690	COG1971	Probably functions as a manganese efflux pump
M1L61_RS22705	COG2911	Protein conserved in bacteria
M1L61_RS22710	COG0729	surface antigen
M1L61_RS22720	COG0752	glycyl-tRNA synthetase alpha subunit
M1L61_RS22725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1L61_RS22730	COG0519	Catalyzes the synthesis of GMP from XMP
M1L61_RS22730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1L61_RS22740	COG0805	protein transport
M1L61_RS22750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M1L61_RS22760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M1L61_RS22765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1L61_RS22765	COG0596	Alpha beta hydrolase
M1L61_RS22770	COG0840	transmembrane signaling receptor activity
M1L61_RS22850	COG3135	benzoate transporter
M1L61_RS22865	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
M1L61_RS22870	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1L61_RS22875	COG3706	GGDEF domain
M1L61_RS22905	COG0302	gtp cyclohydrolase
M1L61_RS22925	COG1566	PFAM secretion protein HlyD family protein
M1L61_RS22935	COG1289	transmembrane transporter activity
M1L61_RS22955	COG1074	ATP-dependent DNA helicase activity
M1L61_RS22960	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1L61_RS22965	COG1127	ABC transporter
M1L61_RS22970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1L61_RS22975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M1L61_RS22995	COG0386	Belongs to the glutathione peroxidase family
M1L61_RS23005	COG1322	Protein conserved in bacteria
M1L61_RS23020	COG0583	DNA-binding transcription factor activity
M1L61_RS23040	COG0667	Aldo Keto reductase
M1L61_RS23045	COG0531	amino acid
M1L61_RS23055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M1L61_RS23060	COG0861	Integral membrane protein TerC family
M1L61_RS23070	COG0584	glycerophosphoryl diester phosphodiesterase
M1L61_RS23090	COG0706	membrane insertase activity
M1L61_RS23095	COG0594	ribonuclease P activity
M1L61_RS23100	COG0230	Belongs to the bacterial ribosomal protein bL34 family