locus-tag	class	description
ACG33_RS00005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACG33_RS00010	COG0582	viral genome integration into host DNA
ACG33_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACG33_RS00030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACG33_RS00065	COG0732	type I restriction modification DNA specificity domain
ACG33_RS00075	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ACG33_RS00130	COG1518	maintenance of DNA repeat elements
ACG33_RS00135	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ACG33_RS00165	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ACG33_RS00170	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS00190	COG1218	3'(2'),5'-bisphosphate nucleotidase
ACG33_RS00200	COG0175	sulfate reduction
ACG33_RS00210	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS00215	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS00225	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS00235	COG0183	Belongs to the thiolase family
ACG33_RS00245	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACG33_RS00260	COG3409	Peptidoglycan-binding domain 1 protein
ACG33_RS00260	COG3267	Type II secretory pathway component ExeA
ACG33_RS00265	COG1131	(ABC) transporter
ACG33_RS00270	COG0842	Transport permease protein
ACG33_RS00275	COG0493	'glutamate synthase
ACG33_RS00280	COG0070	glutamate synthase
ACG33_RS00280	COG0067	glutamate synthase
ACG33_RS00280	COG0069	glutamate synthase activity
ACG33_RS00295	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS00340	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS00345	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS00350	COG0183	Belongs to the thiolase family
ACG33_RS00355	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS00360	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS00365	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS00400	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS00415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS00425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS00430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS00440	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ACG33_RS00450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS00455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACG33_RS00460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACG33_RS00460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACG33_RS00465	COG1703	isobutyryl-CoA mutase activity
ACG33_RS00475	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS00480	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS00495	COG1902	pentaerythritol trinitrate reductase activity
ACG33_RS00500	COG0339	signal peptide processing
ACG33_RS00505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ACG33_RS00510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACG33_RS00520	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ACG33_RS00525	COG0408	coproporphyrinogen oxidase activity
ACG33_RS00535	COG2922	Belongs to the Smg family
ACG33_RS00540	COG0758	DNA mediated transformation
ACG33_RS00550	COG0242	peptide deformylase activity
ACG33_RS00555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACG33_RS00560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACG33_RS00570	COG5000	phosphorelay sensor kinase activity
ACG33_RS00575	COG2204	response regulator
ACG33_RS00585	COG0018	arginyl-trna synthetase
ACG33_RS00590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACG33_RS00595	COG1595	DNA-templated transcription, initiation
ACG33_RS00620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACG33_RS00635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACG33_RS00635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACG33_RS00645	COG0284	orotidine-5'-phosphate decarboxylase activity
ACG33_RS00650	COG0427	acetyl-CoA hydrolase
ACG33_RS00660	COG3038	cytochrome b561
ACG33_RS00665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACG33_RS00675	COG0534	Mate efflux family protein
ACG33_RS00680	COG2918	glutathione biosynthetic process
ACG33_RS00690	COG4191	Histidine kinase
ACG33_RS00720	COG1131	(ABC) transporter
ACG33_RS00725	COG0842	Transport permease protein
ACG33_RS00730	COG0347	Belongs to the P(II) protein family
ACG33_RS00740	COG0028	Belongs to the TPP enzyme family
ACG33_RS00745	COG0183	Belongs to the thiolase family
ACG33_RS00750	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACG33_RS00750	COG1024	Enoyl-CoA hydratase
ACG33_RS00765	COG0823	Involved in the tonB-independent uptake of proteins
ACG33_RS00765	COG1506	peptidase
ACG33_RS00785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACG33_RS00790	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACG33_RS00830	COG2815	serine threonine protein kinase
ACG33_RS00830	COG0515	serine threonine protein kinase
ACG33_RS00835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACG33_RS00880	COG2027	D-alanyl-D-alanine carboxypeptidase
ACG33_RS00895	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACG33_RS00900	COG0363	glucosamine-6-phosphate deaminase activity
ACG33_RS00905	COG0837	glucose binding
ACG33_RS00910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACG33_RS00945	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ACG33_RS00950	COG2894	cell division
ACG33_RS00975	COG2223	nitrite transmembrane transporter activity
ACG33_RS00990	COG2119	membrane
ACG33_RS00995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACG33_RS01030	COG0515	serine threonine protein kinase
ACG33_RS01035	COG2032	superoxide dismutase activity
ACG33_RS01040	COG0625	glutathione transferase activity
ACG33_RS01065	COG2264	protein methyltransferase activity
ACG33_RS01075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACG33_RS01090	COG0741	lytic transglycosylase activity
ACG33_RS01110	COG0358	DNA primase activity
ACG33_RS01115	COG1610	YqeY-like protein
ACG33_RS01120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACG33_RS01150	COG0617	tRNA 3'-terminal CCA addition
ACG33_RS01170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACG33_RS01200	COG1484	DNA-dependent DNA replication
ACG33_RS01225	COG2226	methyltransferase
ACG33_RS01250	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS01265	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS01280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACG33_RS01285	COG0022	dehydrogenase e1 component
ACG33_RS01290	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACG33_RS01300	COG1024	Enoyl-CoA hydratase
ACG33_RS01315	COG2909	trisaccharide binding
ACG33_RS01330	COG0668	transmembrane transport
ACG33_RS01335	COG1388	LysM domain
ACG33_RS01335	COG0741	lytic transglycosylase activity
ACG33_RS01350	COG1611	Belongs to the LOG family
ACG33_RS01385	COG2945	thiolester hydrolase activity
ACG33_RS01430	COG0543	2 iron, 2 sulfur cluster binding
ACG33_RS01435	COG0540	Belongs to the ATCase OTCase family
ACG33_RS01440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACG33_RS01445	COG1678	Uncharacterized ACR, COG1678
ACG33_RS01455	COG0189	ligase activity
ACG33_RS01475	COG0840	transmembrane signaling receptor activity
ACG33_RS01480	COG0643	Histidine kinase
ACG33_RS01480	COG0784	Response regulator, receiver
ACG33_RS01480	COG2198	Histidine kinase
ACG33_RS01490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACG33_RS01500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACG33_RS01520	COG1397	ADP-ribosylglycohydrolase
ACG33_RS01525	COG1506	peptidase
ACG33_RS01525	COG0823	Involved in the tonB-independent uptake of proteins
ACG33_RS01535	COG1011	Hydrolase
ACG33_RS01540	COG0724	RNA recognition motif
ACG33_RS01560	COG3608	succinylglutamate desuccinylase aspartoacylase
ACG33_RS01565	COG0724	RNA recognition motif
ACG33_RS01575	COG1166	arginine decarboxylase activity
ACG33_RS01595	COG3590	peptidase
ACG33_RS01600	COG1704	LemA family
ACG33_RS01605	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ACG33_RS01625	COG2096	Adenosyltransferase
ACG33_RS01635	COG0483	inositol monophosphate 1-phosphatase activity
ACG33_RS01640	COG1120	ATPase activity
ACG33_RS01645	COG0792	nuclease activity
ACG33_RS01650	COG3107	peptidoglycan biosynthetic process
ACG33_RS01665	COG2001	Belongs to the MraZ family
ACG33_RS01675	COG3116	cell division
ACG33_RS01690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACG33_RS01695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACG33_RS01700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACG33_RS01705	COG0772	Belongs to the SEDS family
ACG33_RS01710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACG33_RS01715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACG33_RS01720	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACG33_RS01725	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACG33_RS01730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACG33_RS01740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACG33_RS01745	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACG33_RS01755	COG0739	heme binding
ACG33_RS01760	COG0653	protein targeting
ACG33_RS01765	COG0494	nUDIX hydrolase
ACG33_RS01770	COG0842	Transport permease protein
ACG33_RS01775	COG1131	(ABC) transporter
ACG33_RS01780	COG1505	serine-type exopeptidase activity
ACG33_RS01785	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ACG33_RS01795	COG0339	signal peptide processing
ACG33_RS01805	COG3876	Protein conserved in bacteria
ACG33_RS01815	COG0488	(ABC) transporter
ACG33_RS01825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACG33_RS01830	COG1477	protein flavinylation
ACG33_RS01835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACG33_RS01845	COG4771	TonB-dependent receptor
ACG33_RS01850	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACG33_RS01865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACG33_RS01895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACG33_RS01910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACG33_RS01915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACG33_RS01925	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACG33_RS01950	COG0488	(ABC) transporter
ACG33_RS01955	COG0724	RNA recognition motif
ACG33_RS01960	COG1872	DUF167
ACG33_RS01990	COG4774	siderophore transport
ACG33_RS02005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ACG33_RS02010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACG33_RS02015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACG33_RS02030	COG1703	isobutyryl-CoA mutase activity
ACG33_RS02030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACG33_RS02030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACG33_RS02035	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS02080	COG0668	transmembrane transport
ACG33_RS02095	COG3634	alkyl hydroperoxide reductase activity
ACG33_RS02110	COG2814	Major facilitator Superfamily
ACG33_RS02120	COG0673	inositol 2-dehydrogenase activity
ACG33_RS02125	COG0471	metal ion transport
ACG33_RS02125	COG0490	domain, Protein
ACG33_RS02135	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ACG33_RS02150	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACG33_RS02175	COG2832	Protein of unknown function (DUF454)
ACG33_RS02180	COG1320	monovalent cation:proton antiporter activity
ACG33_RS02185	COG2212	antiporter activity
ACG33_RS02195	COG0651	ATP synthesis coupled electron transport
ACG33_RS02200	COG1006	Multisubunit Na H antiporter MnhC subunit
ACG33_RS02205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACG33_RS02205	COG2111	Na H antiporter
ACG33_RS02210	COG0492	ferredoxin-NADP+ reductase activity
ACG33_RS02215	COG1946	Acyl-CoA thioesterase
ACG33_RS02235	COG0175	sulfate reduction
ACG33_RS02250	COG0277	FAD linked oxidase domain protein
ACG33_RS02255	COG0501	Belongs to the peptidase M48B family
ACG33_RS02275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACG33_RS02285	COG0314	molybdopterin synthase activity
ACG33_RS02290	COG0746	molybdenum cofactor guanylyltransferase activity
ACG33_RS02290	COG0315	cyclic pyranopterin monophosphate synthase activity
ACG33_RS02295	COG0315	cyclic pyranopterin monophosphate synthase activity
ACG33_RS02300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACG33_RS02305	COG0303	'Molybdopterin
ACG33_RS02325	COG4149	molybdate abc transporter
ACG33_RS02330	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ACG33_RS02340	COG3800	Transcriptional regulator
ACG33_RS02340	COG1396	sequence-specific DNA binding
ACG33_RS02350	COG0583	DNA-binding transcription factor activity
ACG33_RS02360	COG1063	alcohol dehydrogenase
ACG33_RS02385	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
ACG33_RS02390	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
ACG33_RS02395	COG2944	sequence-specific DNA binding
ACG33_RS02410	COG0217	transcriptional regulatory protein
ACG33_RS02430	COG1119	ATPase activity
ACG33_RS02435	COG0384	phenazine biosynthesis protein PhzF
ACG33_RS02460	COG0588	phosphoglycerate mutase activity
ACG33_RS02465	COG2902	Dehydrogenase
ACG33_RS02485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACG33_RS02495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACG33_RS02500	COG0626	cystathionine gamma-synthase activity
ACG33_RS02505	COG3278	Belongs to the heme-copper respiratory oxidase family
ACG33_RS02520	COG2010	Cytochrome c
ACG33_RS02525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACG33_RS02530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACG33_RS02540	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ACG33_RS02545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACG33_RS02555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACG33_RS02560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACG33_RS02565	COG0193	aminoacyl-tRNA hydrolase activity
ACG33_RS02570	COG0012	GTP binding
ACG33_RS02575	COG0582	viral genome integration into host DNA
ACG33_RS02605	COG1196	nuclear chromosome segregation
ACG33_RS02610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACG33_RS02625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACG33_RS02665	COG4584	PFAM Integrase catalytic
ACG33_RS02670	COG1484	DNA-dependent DNA replication
ACG33_RS02715	COG1396	sequence-specific DNA binding
ACG33_RS02725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACG33_RS02740	COG2010	Cytochrome c
ACG33_RS02770	COG0640	Transcriptional regulator
ACG33_RS02810	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ACG33_RS02830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACG33_RS02835	COG0582	viral genome integration into host DNA
ACG33_RS02865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACG33_RS02875	COG0116	Belongs to the methyltransferase superfamily
ACG33_RS02875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACG33_RS02885	COG0720	synthase
ACG33_RS02890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACG33_RS02900	COG0174	glutamine synthetase
ACG33_RS02905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACG33_RS02910	COG3842	ATPase activity
ACG33_RS02915	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACG33_RS02920	COG1177	transmembrane transport
ACG33_RS02930	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ACG33_RS02935	COG0538	isocitrate dehydrogenase activity
ACG33_RS02940	COG5002	protein histidine kinase activity
ACG33_RS02945	COG0745	RESPONSE REGULATOR receiver
ACG33_RS02960	COG0859	PFAM glycosyl transferase family 9
ACG33_RS02965	COG3642	lipopolysaccharide core region biosynthetic process
ACG33_RS02970	COG1560	Kdo2-lipid A biosynthetic process
ACG33_RS02980	COG1519	Transferase
ACG33_RS03005	COG1538	Outer membrane efflux protein
ACG33_RS03010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACG33_RS03015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACG33_RS03020	COG5001	Diguanylate cyclase
ACG33_RS03020	COG5002	protein histidine kinase activity
ACG33_RS03025	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ACG33_RS03030	COG0205	6-phosphofructokinase activity
ACG33_RS03035	COG0563	adenylate kinase activity
ACG33_RS03040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ACG33_RS03050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACG33_RS03085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACG33_RS03090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACG33_RS03100	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ACG33_RS03105	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACG33_RS03110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACG33_RS03115	COG0126	phosphoglycerate kinase activity
ACG33_RS03120	COG0469	pyruvate kinase activity
ACG33_RS03145	COG2239	Acts as a magnesium transporter
ACG33_RS03150	COG1660	Displays ATPase and GTPase activities
ACG33_RS03165	COG1137	ATPase activity
ACG33_RS03180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACG33_RS03195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACG33_RS03200	COG0723	plastoquinol--plastocyanin reductase activity
ACG33_RS03205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACG33_RS03210	COG2857	Cytochrome c1
ACG33_RS03215	COG0625	glutathione transferase activity
ACG33_RS03220	COG2969	positive regulation of protein catabolic process
ACG33_RS03225	COG0259	pyridoxamine-phosphate oxidase activity
ACG33_RS03230	COG0077	Prephenate dehydratase
ACG33_RS03230	COG1605	Chorismate mutase
ACG33_RS03235	COG3706	GGDEF domain
ACG33_RS03245	COG1178	ABC-type Fe3 transport system permease component
ACG33_RS03250	COG3842	ATPase activity
ACG33_RS03255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACG33_RS03260	COG0494	nUDIX hydrolase
ACG33_RS03265	COG1981	membrane
ACG33_RS03280	COG0316	Belongs to the HesB IscA family
ACG33_RS03285	COG0248	Ppx GppA phosphatase
ACG33_RS03290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACG33_RS03295	COG0739	heme binding
ACG33_RS03300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACG33_RS03340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACG33_RS03345	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ACG33_RS03345	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ACG33_RS03350	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACG33_RS03360	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACG33_RS03440	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS03445	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS03450	COG1053	succinate dehydrogenase
ACG33_RS03460	COG4774	siderophore transport
ACG33_RS03475	COG1012	belongs to the aldehyde dehydrogenase family
ACG33_RS03505	COG0183	Belongs to the thiolase family
ACG33_RS03510	COG0427	acetyl-CoA hydrolase
ACG33_RS03515	COG1042	CoA-binding domain protein
ACG33_RS03515	COG0045	succinate-CoA ligase (ADP-forming) activity
ACG33_RS03515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACG33_RS03520	COG2030	dehydratase
ACG33_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS03535	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS03540	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS03545	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS03580	COG1309	transcriptional regulator
ACG33_RS03585	COG1012	belongs to the aldehyde dehydrogenase family
ACG33_RS03590	COG1024	Enoyl-CoA hydratase
ACG33_RS03615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACG33_RS03620	COG4774	siderophore transport
ACG33_RS03625	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS03630	COG1024	Enoyl-CoA hydratase
ACG33_RS03645	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS03660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACG33_RS03665	COG4770	biotin carboxylase activity
ACG33_RS03670	COG2271	Major facilitator Superfamily
ACG33_RS03675	COG1595	DNA-templated transcription, initiation
ACG33_RS03730	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS03740	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS03745	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS03755	COG4753	response regulator
ACG33_RS03755	COG2207	Transcriptional regulator
ACG33_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS03815	COG3976	FMN-binding domain protein
ACG33_RS03815	COG1053	succinate dehydrogenase
ACG33_RS03855	COG4774	siderophore transport
ACG33_RS03855	COG1629	transport
ACG33_RS03875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS03905	COG1024	Enoyl-CoA hydratase
ACG33_RS03910	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ACG33_RS03915	COG1024	Enoyl-CoA hydratase
ACG33_RS03920	COG0145	ligase activity
ACG33_RS03925	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ACG33_RS03930	COG4647	ligase activity
ACG33_RS03935	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS03940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS03970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACG33_RS03995	COG2010	Cytochrome c
ACG33_RS04005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACG33_RS04010	COG0842	Transport permease protein
ACG33_RS04010	COG1129	ABC transporter
ACG33_RS04015	COG0842	Transport permease protein
ACG33_RS04020	COG1595	DNA-templated transcription, initiation
ACG33_RS04030	COG0786	glutamate:sodium symporter activity
ACG33_RS04040	COG0288	reversible hydration of carbon dioxide
ACG33_RS04050	COG0745	RESPONSE REGULATOR receiver
ACG33_RS04065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACG33_RS04070	COG4660	Part of a membrane complex involved in electron transport
ACG33_RS04075	COG4659	FMN binding
ACG33_RS04090	COG2878	Part of a membrane complex involved in electron transport
ACG33_RS04100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACG33_RS04100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACG33_RS04120	COG0489	protein tyrosine kinase activity
ACG33_RS04125	COG0717	Belongs to the dCTP deaminase family
ACG33_RS04135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACG33_RS04140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACG33_RS04155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACG33_RS04175	COG1254	Belongs to the acylphosphatase family
ACG33_RS04180	COG0741	lytic transglycosylase activity
ACG33_RS04185	COG1183	phosphatidylcholine synthase activity
ACG33_RS04190	COG1573	uracil-dna glycosylase
ACG33_RS04195	COG0456	acetyltransferase
ACG33_RS04200	COG0735	belongs to the Fur family
ACG33_RS04210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACG33_RS04215	COG2270	Major facilitator Superfamily
ACG33_RS04220	COG3228	Belongs to the MtfA family
ACG33_RS04235	COG0714	Associated with various cellular activities
ACG33_RS04240	COG0525	valine-tRNA ligase activity
ACG33_RS04250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACG33_RS04255	COG0795	lipopolysaccharide-transporting ATPase activity
ACG33_RS04260	COG0795	lipopolysaccharide-transporting ATPase activity
ACG33_RS04285	COG1131	(ABC) transporter
ACG33_RS04310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACG33_RS04310	COG0758	DNA mediated transformation
ACG33_RS04320	COG0617	tRNA 3'-terminal CCA addition
ACG33_RS04335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACG33_RS04345	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACG33_RS04350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACG33_RS04350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACG33_RS04355	COG0802	atpase or kinase
ACG33_RS04360	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACG33_RS04365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACG33_RS04370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACG33_RS04375	COG1923	regulation of RNA biosynthetic process
ACG33_RS04380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACG33_RS04385	COG0330	HflC and HflK could
ACG33_RS04390	COG0330	HflC and HflK could
ACG33_RS04400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACG33_RS04420	COG3108	Peptidase M15
ACG33_RS04425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACG33_RS04430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACG33_RS04435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACG33_RS04440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACG33_RS04455	COG0183	Belongs to the thiolase family
ACG33_RS04460	COG1024	Enoyl-CoA hydratase
ACG33_RS04460	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACG33_RS04475	COG0582	viral genome integration into host DNA
ACG33_RS04485	COG0643	Histidine kinase
ACG33_RS04485	COG2198	Histidine kinase
ACG33_RS04490	COG0840	transmembrane signaling receptor activity
ACG33_RS04495	COG0835	chemotaxis
ACG33_RS04505	COG0745	RESPONSE REGULATOR receiver
ACG33_RS04515	COG2201	protein-glutamate methylesterase activity
ACG33_RS04520	COG2199	diguanylate cyclase activity
ACG33_RS04520	COG2200	EAL domain
ACG33_RS04520	COG2202	Pas domain
ACG33_RS04535	COG0058	SHG alpha-glucan phosphorylase activity
ACG33_RS04545	COG0557	exoribonuclease II activity
ACG33_RS04555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACG33_RS04560	COG0360	Binds together with S18 to 16S ribosomal RNA
ACG33_RS04565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACG33_RS04575	COG0359	binds to the 23S rRNA
ACG33_RS04585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACG33_RS04600	COG2815	serine threonine protein kinase
ACG33_RS04600	COG0515	serine threonine protein kinase
ACG33_RS04625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACG33_RS04635	COG0741	lytic transglycosylase activity
ACG33_RS04635	COG1388	LysM domain
ACG33_RS04640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACG33_RS04660	COG0328	RNA-DNA hybrid ribonuclease activity
ACG33_RS04695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACG33_RS04745	COG2244	polysaccharide biosynthetic process
ACG33_RS04810	COG3959	Transketolase, thiamine diphosphate binding domain
ACG33_RS04815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACG33_RS04820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACG33_RS04870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACG33_RS04895	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACG33_RS04900	COG0740	serine-type endopeptidase activity
ACG33_RS04905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACG33_RS04910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACG33_RS04975	COG0726	polysaccharide deacetylase
ACG33_RS04990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACG33_RS04995	COG2076	Multidrug Resistance protein
ACG33_RS05000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACG33_RS05005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACG33_RS05005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACG33_RS05010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACG33_RS05015	COG0463	Glycosyl transferase, family 2
ACG33_RS05045	COG2801	Transposase and inactivated derivatives
ACG33_RS05060	COG0671	phosphoesterase, PA-phosphatase related
ACG33_RS05080	COG4536	flavin adenine dinucleotide binding
ACG33_RS05090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACG33_RS05095	COG0228	four-way junction DNA binding
ACG33_RS05100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACG33_RS05105	COG0336	Belongs to the RNA methyltransferase TrmD family
ACG33_RS05110	COG0335	large ribosomal subunit rRNA binding
ACG33_RS05120	COG0616	signal peptide processing
ACG33_RS05130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ACG33_RS05135	COG0514	ATP-dependent DNA helicase (RecQ)
ACG33_RS05145	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACG33_RS05170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACG33_RS05190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACG33_RS05195	COG0081	regulation of translation
ACG33_RS05200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACG33_RS05205	COG0222	ribosome binding
ACG33_RS05210	COG0085	RNA polymerase activity
ACG33_RS05215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACG33_RS05220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACG33_RS05225	COG0049	tRNA binding
ACG33_RS05230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACG33_RS05235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACG33_RS05240	COG0051	transcription antitermination factor activity, RNA binding
ACG33_RS05245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACG33_RS05250	COG0088	Forms part of the polypeptide exit tunnel
ACG33_RS05255	COG0089	rRNA binding
ACG33_RS05260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACG33_RS05265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACG33_RS05270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACG33_RS05280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACG33_RS05285	COG0255	Belongs to the universal ribosomal protein uL29 family
ACG33_RS05290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACG33_RS05295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACG33_RS05300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACG33_RS05305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACG33_RS05310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACG33_RS05315	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACG33_RS05320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACG33_RS05325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACG33_RS05330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACG33_RS05335	COG1841	ribosomal large subunit assembly
ACG33_RS05340	COG0200	Binds to the 23S rRNA
ACG33_RS05345	COG0201	protein transport
ACG33_RS05350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACG33_RS05355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACG33_RS05360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACG33_RS05370	COG0203	ribosomal protein L17
ACG33_RS05375	COG2989	Protein conserved in bacteria
ACG33_RS05385	COG0587	DNA-directed DNA polymerase activity
ACG33_RS05400	COG1970	mechanosensitive ion channel activity
ACG33_RS05405	COG0006	proline dipeptidase activity
ACG33_RS05430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACG33_RS05435	COG1702	phosphate starvation-inducible protein PhoH
ACG33_RS05440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACG33_RS05445	COG4535	Mg2 and Co2 transporter CorC
ACG33_RS05450	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACG33_RS05455	COG1968	undecaprenyl-diphosphatase activity
ACG33_RS05460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACG33_RS05470	COG2183	response to ionizing radiation
ACG33_RS05495	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACG33_RS05500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACG33_RS05505	COG4771	TonB-dependent receptor
ACG33_RS05510	COG0252	asparaginase activity
ACG33_RS05520	COG2827	Endonuclease containing a URI domain
ACG33_RS05575	COG1815	bacterial-type flagellum-dependent cell motility
ACG33_RS05580	COG1558	bacterial-type flagellum-dependent cell motility
ACG33_RS05595	COG4787	bacterial-type flagellum-dependent cell motility
ACG33_RS05620	COG3951	Flagellar rod assembly protein muramidase FlgJ
ACG33_RS05620	COG1705	Flagellar rod assembly protein muramidase FlgJ
ACG33_RS05660	COG3550	peptidyl-serine autophosphorylation
ACG33_RS05665	COG1396	sequence-specific DNA binding
ACG33_RS05680	COG1677	Flagellar hook-basal body complex protein FliE
ACG33_RS05690	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACG33_RS05695	COG1317	bacterial-type flagellum organization
ACG33_RS05755	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACG33_RS05780	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ACG33_RS05785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACG33_RS05790	COG1360	Flagellar Motor Protein
ACG33_RS05810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACG33_RS05825	COG0745	RESPONSE REGULATOR receiver
ACG33_RS05830	COG2198	Histidine kinase
ACG33_RS05830	COG0643	Histidine kinase
ACG33_RS05840	COG0835	chemotaxis
ACG33_RS05845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACG33_RS05850	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACG33_RS05855	COG2201	protein-glutamate methylesterase activity
ACG33_RS05865	COG0495	leucyl-tRNA aminoacylation
ACG33_RS05895	COG1466	dna polymerase III delta subunit
ACG33_RS05900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACG33_RS05910	COG0799	negative regulation of ribosome biogenesis
ACG33_RS05920	COG0424	maF-like protein
ACG33_RS05935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACG33_RS05940	COG0312	modulator of DNA gyrase
ACG33_RS05950	COG3267	Type II secretory pathway component ExeA
ACG33_RS05950	COG3409	Peptidoglycan-binding domain 1 protein
ACG33_RS05965	COG3028	Belongs to the UPF0307 family
ACG33_RS05970	COG0312	modulator of DNA gyrase
ACG33_RS05975	COG1295	ribonuclease BN
ACG33_RS05980	COG5002	protein histidine kinase activity
ACG33_RS05980	COG0784	Response regulator, receiver
ACG33_RS05985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACG33_RS05990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACG33_RS06005	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ACG33_RS06010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACG33_RS06015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACG33_RS06070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACG33_RS06085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACG33_RS06105	COG3079	Belongs to the UPF0149 family
ACG33_RS06110	COG0006	proline dipeptidase activity
ACG33_RS06115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACG33_RS06120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACG33_RS06130	COG0189	ligase activity
ACG33_RS06135	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACG33_RS06140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACG33_RS06145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACG33_RS06155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACG33_RS06160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACG33_RS06165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACG33_RS06175	COG0009	L-threonylcarbamoyladenylate synthase
ACG33_RS06200	COG1331	Highly conserved protein containing a thioredoxin domain
ACG33_RS06205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACG33_RS06210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACG33_RS06215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACG33_RS06235	COG1187	pseudouridine synthase activity
ACG33_RS06245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACG33_RS06250	COG2967	ApaG domain
ACG33_RS06255	COG0589	response to stress
ACG33_RS06260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACG33_RS06265	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACG33_RS06270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACG33_RS06275	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACG33_RS06285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACG33_RS06320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACG33_RS06330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACG33_RS06335	COG0321	lipoyl(octanoyl) transferase activity
ACG33_RS06340	COG2921	Belongs to the UPF0250 family
ACG33_RS06345	COG1686	Belongs to the peptidase S11 family
ACG33_RS06350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACG33_RS06355	COG2951	lytic endotransglycosylase activity
ACG33_RS06360	COG0772	Belongs to the SEDS family
ACG33_RS06365	COG0768	penicillin binding
ACG33_RS06375	COG1792	Involved in formation and maintenance of cell shape
ACG33_RS06380	COG1077	Cell shape determining protein MreB Mrl
ACG33_RS06385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACG33_RS06390	COG0154	amidase activity
ACG33_RS06395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACG33_RS06400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACG33_RS06405	COG0640	Transcriptional regulator
ACG33_RS06420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ACG33_RS06445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACG33_RS06450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ACG33_RS06460	COG2423	ornithine cyclodeaminase activity
ACG33_RS06470	COG4774	siderophore transport
ACG33_RS06485	COG2030	dehydratase
ACG33_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS06505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS06515	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACG33_RS06520	COG0343	queuine tRNA-ribosyltransferase activity
ACG33_RS06525	COG0628	permease
ACG33_RS06530	COG1253	flavin adenine dinucleotide binding
ACG33_RS06535	COG1862	Preprotein translocase
ACG33_RS06540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACG33_RS06555	COG0531	amino acid
ACG33_RS06565	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ACG33_RS06570	COG1104	cysteine desulfurase activity
ACG33_RS06580	COG0316	Belongs to the HesB IscA family
ACG33_RS06585	COG0105	UTP biosynthetic process
ACG33_RS06590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACG33_RS06605	COG0124	histidyl-tRNA synthetase
ACG33_RS06615	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACG33_RS06620	COG1160	GTP binding
ACG33_RS06625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACG33_RS06630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACG33_RS06640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACG33_RS06650	COG1570	exodeoxyribonuclease VII activity
ACG33_RS06665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACG33_RS06665	COG0519	Catalyzes the synthesis of GMP from XMP
ACG33_RS06700	COG3550	peptidyl-serine autophosphorylation
ACG33_RS06710	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACG33_RS06725	COG1686	Belongs to the peptidase S11 family
ACG33_RS06735	COG0025	NhaP-type Na H and K H
ACG33_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS06745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACG33_RS06760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACG33_RS06765	COG2867	negative regulation of translational initiation
ACG33_RS06770	COG2914	Belongs to the UPF0125 (RnfH) family
ACG33_RS06775	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACG33_RS06780	COG0735	belongs to the Fur family
ACG33_RS06785	COG0497	DNA recombination
ACG33_RS06790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACG33_RS06795	COG1420	regulation of RNA biosynthetic process
ACG33_RS06800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACG33_RS06805	COG0443	Heat shock 70 kDa protein
ACG33_RS06810	COG0484	heat shock protein binding
ACG33_RS06815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACG33_RS06820	COG0505	Belongs to the CarA family
ACG33_RS06825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACG33_RS06830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACG33_RS06840	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ACG33_RS06845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACG33_RS06850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACG33_RS06855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACG33_RS06860	COG0149	triose-phosphate isomerase activity
ACG33_RS06875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACG33_RS06880	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACG33_RS06885	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACG33_RS06890	COG0649	NAD binding
ACG33_RS06895	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ACG33_RS06905	COG1034	ATP synthesis coupled electron transport
ACG33_RS06910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACG33_RS06915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACG33_RS06925	COG0713	ATP synthesis coupled electron transport
ACG33_RS06940	COG1007	ATP synthesis coupled electron transport
ACG33_RS06950	COG0779	Required for maturation of 30S ribosomal subunits
ACG33_RS06955	COG2251	uridine kinase activity
ACG33_RS06955	COG0195	Participates in both transcription termination and antitermination
ACG33_RS06960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACG33_RS06965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACG33_RS06970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACG33_RS06975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACG33_RS06980	COG1185	polyribonucleotide nucleotidyltransferase activity
ACG33_RS06995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACG33_RS07005	COG1196	nuclear chromosome segregation
ACG33_RS07015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACG33_RS07020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACG33_RS07030	COG2917	probably involved in intracellular septation
ACG33_RS07035	COG0009	L-threonylcarbamoyladenylate synthase
ACG33_RS07040	COG0180	Tryptophanyl-tRNA synthetase
ACG33_RS07050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACG33_RS07055	COG1187	pseudouridine synthase activity
ACG33_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS07065	COG1562	ergosterol biosynthetic process
ACG33_RS07070	COG1322	Protein conserved in bacteria
ACG33_RS07085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACG33_RS07090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACG33_RS07095	COG1605	Chorismate mutase
ACG33_RS07095	COG0077	Prephenate dehydratase
ACG33_RS07100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACG33_RS07105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACG33_RS07110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACG33_RS07120	COG0776	regulation of translation
ACG33_RS07130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ACG33_RS07140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACG33_RS07175	COG2814	Major facilitator Superfamily
ACG33_RS07200	COG0436	Aminotransferase
ACG33_RS07220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACG33_RS07225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACG33_RS07230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACG33_RS07235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACG33_RS07240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACG33_RS07245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACG33_RS07245	COG0072	phenylalanine-tRNA ligase activity
ACG33_RS07250	COG0776	regulation of translation
ACG33_RS07305	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACG33_RS07310	COG3657	addiction module killer protein
ACG33_RS07350	COG0673	inositol 2-dehydrogenase activity
ACG33_RS07365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACG33_RS07405	COG0438	transferase activity, transferring glycosyl groups
ACG33_RS07410	COG0438	transferase activity, transferring glycosyl groups
ACG33_RS07465	COG4584	PFAM Integrase catalytic
ACG33_RS07470	COG1484	DNA-dependent DNA replication
ACG33_RS07495	COG0546	phosphoglycolate phosphatase activity
ACG33_RS07495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACG33_RS07500	COG5002	protein histidine kinase activity
ACG33_RS07500	COG2198	Histidine kinase
ACG33_RS07500	COG0784	Response regulator, receiver
ACG33_RS07505	COG0745	RESPONSE REGULATOR receiver
ACG33_RS07530	COG4974	Belongs to the 'phage' integrase family
ACG33_RS07540	COG5001	Diguanylate cyclase
ACG33_RS07540	COG4251	negative regulation of phosphorylation
ACG33_RS07540	COG3706	GGDEF domain
ACG33_RS07540	COG2203	Gaf domain
ACG33_RS07550	COG1858	cytochrome C peroxidase
ACG33_RS07555	COG2010	Cytochrome c
ACG33_RS07570	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS07575	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS07605	COG0527	aspartate kinase activity
ACG33_RS07620	COG0140	phosphoribosyl-ATP diphosphatase activity
ACG33_RS07620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACG33_RS07625	COG0107	imidazoleglycerol-phosphate synthase activity
ACG33_RS07630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACG33_RS07635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACG33_RS07640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACG33_RS07645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACG33_RS07650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACG33_RS07665	COG2086	electron transfer activity
ACG33_RS07675	COG0436	Aminotransferase
ACG33_RS07685	COG1074	ATP-dependent DNA helicase activity
ACG33_RS07725	COG2165	general secretion pathway protein
ACG33_RS07740	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS07745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACG33_RS07750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACG33_RS07755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACG33_RS07760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACG33_RS07765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACG33_RS07770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACG33_RS07785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACG33_RS07790	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACG33_RS07790	COG1024	Enoyl-CoA hydratase
ACG33_RS07815	COG3360	Dodecin
ACG33_RS07825	COG1484	DNA-dependent DNA replication
ACG33_RS07830	COG4584	PFAM Integrase catalytic
ACG33_RS07860	COG4774	siderophore transport
ACG33_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS07885	COG0346	lactoylglutathione lyase activity
ACG33_RS07890	COG1063	alcohol dehydrogenase
ACG33_RS07905	COG1902	pentaerythritol trinitrate reductase activity
ACG33_RS07910	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS07925	COG0516	GMP reductase activity
ACG33_RS07925	COG0517	IMP dehydrogenase activity
ACG33_RS07950	COG0778	Nitroreductase
ACG33_RS07965	COG3088	subunit of a heme lyase
ACG33_RS07970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACG33_RS08000	COG4133	protoheme IX ABC transporter activity
ACG33_RS08030	COG0281	malic enzyme
ACG33_RS08050	COG0322	excinuclease ABC activity
ACG33_RS08055	COG1573	uracil-dna glycosylase
ACG33_RS08065	COG2224	Isocitrate lyase
ACG33_RS08070	COG0583	DNA-binding transcription factor activity
ACG33_RS08095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACG33_RS08100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACG33_RS08105	COG0066	3-isopropylmalate dehydratase activity
ACG33_RS08110	COG0473	3-isopropylmalate dehydrogenase activity
ACG33_RS08115	COG0626	cystathionine gamma-synthase activity
ACG33_RS08125	COG0129	dihydroxy-acid dehydratase activity
ACG33_RS08130	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ACG33_RS08140	COG1012	belongs to the aldehyde dehydrogenase family
ACG33_RS08145	COG1024	Enoyl-CoA hydratase
ACG33_RS08155	COG1643	Atp-dependent helicase
ACG33_RS08180	COG3956	TIGRFAM MazG family protein
ACG33_RS08205	COG0482	sulfurtransferase activity
ACG33_RS08220	COG4804	nuclease activity
ACG33_RS08225	COG2003	Belongs to the UPF0758 family
ACG33_RS08240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACG33_RS08250	COG2801	Transposase and inactivated derivatives
ACG33_RS08265	COG1475	DNA binding
ACG33_RS08300	COG1192	Involved in chromosome partitioning
ACG33_RS08335	COG1611	Belongs to the LOG family
ACG33_RS08340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACG33_RS08360	COG0842	Transport permease protein
ACG33_RS08365	COG0842	Transport permease protein
ACG33_RS08370	COG1131	(ABC) transporter
ACG33_RS08375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACG33_RS08380	COG1309	transcriptional regulator
ACG33_RS08385	COG0583	DNA-binding transcription factor activity
ACG33_RS08405	COG4962	Type ii secretion system protein e
ACG33_RS08410	COG3838	Conjugal transfer protein Trbc
ACG33_RS08420	COG3451	type IV secretory pathway VirB4
ACG33_RS08435	COG3846	protein secretion by the type IV secretion system
ACG33_RS08475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACG33_RS08510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACG33_RS08520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACG33_RS08550	COG1396	sequence-specific DNA binding
ACG33_RS08555	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ACG33_RS08565	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACG33_RS08570	COG0602	queuosine metabolic process
ACG33_RS08575	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ACG33_RS08580	COG2885	chlorophyll binding
ACG33_RS08585	COG0823	Involved in the tonB-independent uptake of proteins
ACG33_RS08605	COG0824	Thioesterase
ACG33_RS08610	COG2255	four-way junction helicase activity
ACG33_RS08615	COG0632	four-way junction helicase activity
ACG33_RS08620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACG33_RS08625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACG33_RS08650	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS08675	COG1764	response to oxidative stress
ACG33_RS08680	COG3189	MarR family transcriptional regulator
ACG33_RS08690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACG33_RS08695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACG33_RS08705	COG0235	Class ii aldolase
ACG33_RS08735	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
ACG33_RS08740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACG33_RS08760	COG4584	PFAM Integrase catalytic
ACG33_RS08765	COG1484	DNA-dependent DNA replication
ACG33_RS08825	COG2801	Transposase and inactivated derivatives
ACG33_RS08855	COG0582	viral genome integration into host DNA
ACG33_RS08885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACG33_RS08890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACG33_RS08900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACG33_RS08905	COG1674	ftsk spoiiie
ACG33_RS08910	COG0492	ferredoxin-NADP+ reductase activity
ACG33_RS08920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACG33_RS08925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACG33_RS08930	COG0542	response to heat
ACG33_RS08935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACG33_RS08940	COG3031	protein transport across the cell outer membrane
ACG33_RS08955	COG1459	type II secretion system
ACG33_RS09000	COG0793	Belongs to the peptidase S41A family
ACG33_RS09015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ACG33_RS09025	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACG33_RS09030	COG0501	Belongs to the peptidase M48B family
ACG33_RS09035	COG1162	GTPase activity
ACG33_RS09040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACG33_RS09045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACG33_RS09050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACG33_RS09060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACG33_RS09065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACG33_RS09070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACG33_RS09080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACG33_RS09095	COG3093	addiction module antidote protein HigA
ACG33_RS09100	COG3549	Plasmid maintenance system killer
ACG33_RS09120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACG33_RS09135	COG1522	sequence-specific DNA binding
ACG33_RS09150	COG0535	radical SAM domain protein
ACG33_RS09155	COG2010	Cytochrome c
ACG33_RS09160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACG33_RS09160	COG1648	precorrin-2 dehydrogenase activity
ACG33_RS09180	COG0783	Belongs to the Dps family
ACG33_RS09185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACG33_RS09225	COG1376	ErfK ybiS ycfS ynhG family protein
ACG33_RS09230	COG0416	fatty acid biosynthetic process
ACG33_RS09235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACG33_RS09245	COG0424	maF-like protein
ACG33_RS09250	COG0564	pseudouridine synthase activity
ACG33_RS09255	COG1530	ribonuclease E activity
ACG33_RS09260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACG33_RS09265	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACG33_RS09270	COG2835	tetraacyldisaccharide 4'-kinase activity
ACG33_RS09275	COG1663	tetraacyldisaccharide 4'-kinase activity
ACG33_RS09280	COG1132	(ABC) transporter
ACG33_RS09285	COG0848	biopolymer transport protein
ACG33_RS09290	COG0811	peptide transport
ACG33_RS09300	COG1136	(ABC) transporter
ACG33_RS09305	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACG33_RS09320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACG33_RS09340	COG1472	Belongs to the glycosyl hydrolase 3 family
ACG33_RS09345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACG33_RS09355	COG0736	holo-[acyl-carrier-protein] synthase activity
ACG33_RS09365	COG1381	Involved in DNA repair and RecF pathway recombination
ACG33_RS09375	COG0571	ribonuclease III activity
ACG33_RS09385	COG0681	Belongs to the peptidase S26 family
ACG33_RS09390	COG0481	GTPase activity
ACG33_RS09415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ACG33_RS09450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACG33_RS09455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACG33_RS09470	COG3737	Protein of unknown function (DUF498/DUF598)
ACG33_RS09480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACG33_RS09485	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACG33_RS09495	COG0585	pseudouridine synthase activity
ACG33_RS09500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACG33_RS09505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACG33_RS09510	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ACG33_RS09515	COG0148	phosphopyruvate hydratase activity
ACG33_RS09520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACG33_RS09525	COG0504	CTP synthase activity
ACG33_RS09530	COG0037	tRNA processing
ACG33_RS09535	COG0825	malonyl-CoA metabolic process
ACG33_RS09555	COG0023	Translation Initiation Factor
ACG33_RS09560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS09565	COG2124	cytochrome p450
ACG33_RS09580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACG33_RS09580	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACG33_RS09585	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACG33_RS09595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACG33_RS09610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACG33_RS09615	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACG33_RS09620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACG33_RS09625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACG33_RS09630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACG33_RS09640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACG33_RS09650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACG33_RS09660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACG33_RS09665	COG0233	cytoplasmic translational termination
ACG33_RS09670	COG0528	UMP kinase activity
ACG33_RS09675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACG33_RS09680	COG0052	Belongs to the universal ribosomal protein uS2 family
ACG33_RS09685	COG0024	Methionine aminopeptidase
ACG33_RS09690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACG33_RS09695	COG0436	Aminotransferase
ACG33_RS09700	COG2171	N-acyltransferase activity
ACG33_RS09705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACG33_RS09710	COG0581	inorganic phosphate transmembrane transporter activity
ACG33_RS09715	COG0573	inorganic phosphate transmembrane transporter activity
ACG33_RS09725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACG33_RS09735	COG0704	Plays a role in the regulation of phosphate uptake
ACG33_RS09750	COG1214	PFAM Peptidase M22, glycoprotease
ACG33_RS09755	COG1199	ATP-dependent helicase activity
ACG33_RS09775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACG33_RS09805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACG33_RS09810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACG33_RS09820	COG0019	diaminopimelate decarboxylase activity
ACG33_RS09845	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ACG33_RS09860	COG3736	Type IV secretory pathway, component VirB8
ACG33_RS09865	COG3704	protein secretion by the type IV secretion system
ACG33_RS09875	COG3451	type IV secretory pathway VirB4
ACG33_RS09940	COG3015	lipoprotein NlpE involved in copper resistance
ACG33_RS09980	COG5002	protein histidine kinase activity
ACG33_RS09980	COG5001	Diguanylate cyclase
ACG33_RS09985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACG33_RS10005	COG1217	gtp-binding protein TYPA
ACG33_RS10025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACG33_RS10035	COG2205	protein histidine kinase activity
ACG33_RS10045	COG2204	response regulator
ACG33_RS10055	COG0579	oxidoreductase
ACG33_RS10060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACG33_RS10065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACG33_RS10075	COG4310	Domain of unknown function (DUF2172)
ACG33_RS10080	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ACG33_RS10090	COG1132	(ABC) transporter
ACG33_RS10130	COG0463	Glycosyl transferase, family 2
ACG33_RS10135	COG1216	Glycosyl transferase, family 2
ACG33_RS10140	COG0367	asparagine synthase
ACG33_RS10170	COG1215	transferase activity, transferring glycosyl groups
ACG33_RS10195	COG1596	polysaccharide export
ACG33_RS10210	COG2204	response regulator
ACG33_RS10215	COG4191	Histidine kinase
ACG33_RS10220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACG33_RS10255	COG1115	amino acid carrier protein
ACG33_RS10260	COG1920	GTP binding
ACG33_RS10320	COG0215	cysteine-tRNA ligase activity
ACG33_RS10325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACG33_RS10340	COG0515	serine threonine protein kinase
ACG33_RS10340	COG2815	serine threonine protein kinase
ACG33_RS10350	COG1286	toxin biosynthetic process
ACG33_RS10360	COG0285	dihydrofolate synthase activity
ACG33_RS10365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACG33_RS10385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACG33_RS10400	COG0688	phosphatidylethanolamine metabolic process
ACG33_RS10405	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ACG33_RS10410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACG33_RS10415	COG1509	lysine 2,3-aminomutase activity
ACG33_RS10430	COG2199	diguanylate cyclase activity
ACG33_RS10430	COG2200	EAL domain
ACG33_RS10430	COG3287	FIST C domain
ACG33_RS10445	COG1722	exodeoxyribonuclease VII activity
ACG33_RS10450	COG0142	geranyltranstransferase activity
ACG33_RS10455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACG33_RS10460	COG1469	GTP cyclohydrolase I activity
ACG33_RS10465	COG0515	serine threonine protein kinase
ACG33_RS10465	COG2815	serine threonine protein kinase
ACG33_RS10470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACG33_RS10480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACG33_RS10485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACG33_RS10500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACG33_RS10500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACG33_RS10505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACG33_RS10510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACG33_RS10520	COG0488	(ABC) transporter
ACG33_RS10530	COG0047	phosphoribosylformylglycinamidine synthase activity
ACG33_RS10530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACG33_RS10550	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ACG33_RS10565	COG0386	Belongs to the glutathione peroxidase family
ACG33_RS10575	COG1116	anion transmembrane transporter activity
ACG33_RS10575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACG33_RS10585	COG1218	3'(2'),5'-bisphosphate nucleotidase
ACG33_RS10595	COG0175	sulfate reduction
ACG33_RS10615	COG3012	SEC-C Motif Domain Protein
ACG33_RS10620	COG4372	Transposase
ACG33_RS10630	COG2801	Transposase and inactivated derivatives
ACG33_RS10640	COG4372	Transposase
ACG33_RS10645	COG3436	PFAM IS66 Orf2 family protein
ACG33_RS10655	COG2130	NADP-dependent
ACG33_RS10665	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS10675	COG3381	protein complex oligomerization
ACG33_RS10690	COG0243	molybdopterin cofactor binding
ACG33_RS10700	COG4774	siderophore transport
ACG33_RS10725	COG2070	2-Nitropropane dioxygenase
ACG33_RS10735	COG1024	Enoyl-CoA hydratase
ACG33_RS10745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACG33_RS10755	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS10760	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS10765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACG33_RS10775	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS10780	COG1053	succinate dehydrogenase
ACG33_RS10785	COG4774	siderophore transport
ACG33_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS10795	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACG33_RS10795	COG1902	pentaerythritol trinitrate reductase activity
ACG33_RS10815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS10825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACG33_RS10830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACG33_RS10840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACG33_RS10845	COG0826	peptidase U32
ACG33_RS10850	COG0826	peptidase U32
ACG33_RS10860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACG33_RS10870	COG2223	nitrite transmembrane transporter activity
ACG33_RS10875	COG0500	methyltransferase
ACG33_RS10895	COG5002	protein histidine kinase activity
ACG33_RS10910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACG33_RS10915	COG2181	nitrate reductase activity
ACG33_RS10920	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ACG33_RS10925	COG1140	nitrate reductase beta subunit
ACG33_RS10930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ACG33_RS10940	COG2853	Lipoprotein
ACG33_RS10960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACG33_RS10965	COG1127	ABC transporter
ACG33_RS10970	COG3588	fructose-bisphosphate aldolase
ACG33_RS10985	COG0719	Fe-S assembly protein
ACG33_RS10990	COG0396	ATPase activity
ACG33_RS10995	COG0719	Fe-S assembly protein
ACG33_RS11005	COG0822	iron-sulfur transferase activity
ACG33_RS11010	COG2151	metal-sulfur cluster biosynthetic enzyme
ACG33_RS11035	COG4566	intracellular signal transduction
ACG33_RS11040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACG33_RS11055	COG1611	Belongs to the LOG family
ACG33_RS11065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACG33_RS11075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACG33_RS11095	COG2217	Heavy metal translocating P-type atpase
ACG33_RS11110	COG0010	Belongs to the arginase family
ACG33_RS11120	COG1686	Belongs to the peptidase S11 family
ACG33_RS11130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ACG33_RS11135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACG33_RS11150	COG2095	MarC family integral membrane protein
ACG33_RS11155	COG0281	malic enzyme
ACG33_RS11155	COG0280	phosphate acetyltransferase
ACG33_RS11160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACG33_RS11165	COG2911	Protein conserved in bacteria
ACG33_RS11170	COG0729	surface antigen
ACG33_RS11185	COG0604	alcohol dehydrogenase
ACG33_RS11190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACG33_RS11195	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACG33_RS11205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACG33_RS11210	COG0418	dihydroorotase activity
ACG33_RS11215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACG33_RS11220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ACG33_RS11230	COG5002	protein histidine kinase activity
ACG33_RS11230	COG5001	Diguanylate cyclase
ACG33_RS11235	COG1230	cation diffusion facilitator family transporter
ACG33_RS11250	COG0735	belongs to the Fur family
ACG33_RS11260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACG33_RS11265	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACG33_RS11270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACG33_RS11275	COG0196	riboflavin kinase activity
ACG33_RS11280	COG0728	peptidoglycan biosynthetic process
ACG33_RS11285	COG0268	Binds directly to 16S ribosomal RNA
ACG33_RS11290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACG33_RS11300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACG33_RS11305	COG0142	geranyltranstransferase activity
ACG33_RS11335	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS11345	COG1733	regulation of RNA biosynthetic process
ACG33_RS11350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACG33_RS11355	COG0183	Belongs to the thiolase family
ACG33_RS11370	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS11380	COG2070	2-Nitropropane dioxygenase
ACG33_RS11390	COG0163	prenyltransferase activity
ACG33_RS11395	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS11425	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS11430	COG2818	Glycosylase
ACG33_RS11445	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACG33_RS11550	COG3609	addiction module antidote protein, CC2985 family
ACG33_RS11610	COG3415	Transposase
ACG33_RS11610	COG2801	Transposase and inactivated derivatives
ACG33_RS11630	COG0543	2 iron, 2 sulfur cluster binding
ACG33_RS11630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACG33_RS11635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACG33_RS11660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACG33_RS11665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACG33_RS11670	COG1546	Belongs to the CinA family
ACG33_RS11675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACG33_RS11680	COG2137	regulation of response to DNA damage stimulus
ACG33_RS11685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACG33_RS11690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACG33_RS11700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACG33_RS11715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACG33_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS11745	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS11750	COG1024	Enoyl-CoA hydratase
ACG33_RS11765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ACG33_RS11775	COG4771	TonB-dependent receptor
ACG33_RS11790	COG1902	pentaerythritol trinitrate reductase activity
ACG33_RS11790	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACG33_RS11800	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS11805	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS11810	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS11815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACG33_RS11820	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS11825	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS11850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACG33_RS11855	COG4263	nitrous-oxide reductase activity
ACG33_RS11875	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ACG33_RS11885	COG2079	MmgE PrpD family protein
ACG33_RS11905	COG1595	DNA-templated transcription, initiation
ACG33_RS11925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACG33_RS11935	COG0542	response to heat
ACG33_RS11960	COG0564	pseudouridine synthase activity
ACG33_RS11970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACG33_RS11970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACG33_RS11975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACG33_RS11980	COG0045	succinate-CoA ligase (ADP-forming) activity
ACG33_RS12040	COG0237	dephospho-CoA kinase activity
ACG33_RS12050	COG0330	HflC and HflK could
ACG33_RS12060	COG0500	methyltransferase
ACG33_RS12075	COG0459	protein refolding
ACG33_RS12080	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACG33_RS12085	COG1324	tolerance protein
ACG33_RS12090	COG4232	protein-disulfide reductase activity
ACG33_RS12100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACG33_RS12105	COG0511	ligase activity, forming carbon-carbon bonds
ACG33_RS12110	COG0439	Biotin carboxylase
ACG33_RS12130	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ACG33_RS12140	COG0151	Belongs to the GarS family
ACG33_RS12150	COG0625	glutathione transferase activity
ACG33_RS12160	COG2200	EAL domain
ACG33_RS12180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACG33_RS12195	COG1011	Hydrolase
ACG33_RS12210	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACG33_RS12210	COG3264	Mechanosensitive ion channel
ACG33_RS12220	COG2937	Belongs to the GPAT DAPAT family
ACG33_RS12235	COG0037	tRNA processing
ACG33_RS12240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACG33_RS12245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACG33_RS12255	COG0297	glycogen (starch) synthase activity
ACG33_RS12265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACG33_RS12275	COG2197	response regulator
ACG33_RS12280	COG3916	Acyl-homoserine-lactone synthase
ACG33_RS12290	COG5265	(ABC) transporter
ACG33_RS12310	COG0823	Involved in the tonB-independent uptake of proteins
ACG33_RS12310	COG1506	peptidase
ACG33_RS12320	COG4771	TonB-dependent receptor
ACG33_RS12330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACG33_RS12335	COG0501	Belongs to the peptidase M48B family
ACG33_RS12340	COG1704	LemA family
ACG33_RS12350	COG4783	chaperone-mediated protein folding
ACG33_RS12360	COG0247	lactate metabolic process
ACG33_RS12365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACG33_RS12375	COG2205	protein histidine kinase activity
ACG33_RS12400	COG0625	glutathione transferase activity
ACG33_RS12405	COG2824	Alkylphosphonate utilization operon protein PhnA
ACG33_RS12435	COG1024	Enoyl-CoA hydratase
ACG33_RS12450	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS12455	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACG33_RS12455	COG1902	pentaerythritol trinitrate reductase activity
ACG33_RS12475	COG1187	pseudouridine synthase activity
ACG33_RS12480	COG1643	Atp-dependent helicase
ACG33_RS12535	COG1187	pseudouridine synthase activity
ACG33_RS12545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACG33_RS12570	COG1966	Carbon starvation protein
ACG33_RS12575	COG1024	Enoyl-CoA hydratase
ACG33_RS12580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACG33_RS12585	COG3083	sulfuric ester hydrolase activity
ACG33_RS12595	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS12655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACG33_RS12700	COG1116	anion transmembrane transporter activity
ACG33_RS12710	COG2814	Major facilitator Superfamily
ACG33_RS12715	COG1566	PFAM secretion protein HlyD family protein
ACG33_RS12780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACG33_RS12785	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACG33_RS12790	COG1877	trehalose-phosphatase activity
ACG33_RS12800	COG2201	protein-glutamate methylesterase activity
ACG33_RS12810	COG0745	RESPONSE REGULATOR receiver
ACG33_RS12820	COG0835	chemotaxis
ACG33_RS12825	COG0840	transmembrane signaling receptor activity
ACG33_RS12830	COG2198	Histidine kinase
ACG33_RS12830	COG0643	Histidine kinase
ACG33_RS12850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACG33_RS12855	COG0659	secondary active sulfate transmembrane transporter activity
ACG33_RS12860	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACG33_RS12865	COG1194	a g-specific adenine glycosylase
ACG33_RS12870	COG2982	Protein involved in outer membrane biogenesis
ACG33_RS12890	COG0784	Response regulator, receiver
ACG33_RS12890	COG4191	Histidine kinase
ACG33_RS12900	COG2197	response regulator
ACG33_RS12905	COG2204	response regulator
ACG33_RS12915	COG0784	Response regulator, receiver
ACG33_RS12915	COG4191	Histidine kinase
ACG33_RS12935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACG33_RS12940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACG33_RS12945	COG1120	ATPase activity
ACG33_RS12960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACG33_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS12970	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS12980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACG33_RS13000	COG0356	it plays a direct role in the translocation of protons across the membrane
ACG33_RS13010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACG33_RS13015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACG33_RS13020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACG33_RS13030	COG2205	protein histidine kinase activity
ACG33_RS13085	COG0582	viral genome integration into host DNA
ACG33_RS13095	COG0583	DNA-binding transcription factor activity
ACG33_RS13100	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS13115	COG1309	transcriptional regulator
ACG33_RS13125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACG33_RS13130	COG1131	(ABC) transporter
ACG33_RS13135	COG0842	Transport permease protein
ACG33_RS13140	COG0842	Transport permease protein
ACG33_RS13155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACG33_RS13160	COG1611	Belongs to the LOG family
ACG33_RS13220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACG33_RS13230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACG33_RS13265	COG0642	Histidine kinase
ACG33_RS13280	COG0745	RESPONSE REGULATOR receiver
ACG33_RS13310	COG2205	protein histidine kinase activity
ACG33_RS13325	COG1484	DNA-dependent DNA replication
ACG33_RS13330	COG4584	PFAM Integrase catalytic
ACG33_RS13355	COG0582	viral genome integration into host DNA
ACG33_RS13370	COG3609	addiction module antidote protein, CC2985 family
ACG33_RS13415	COG3549	Plasmid maintenance system killer
ACG33_RS13435	COG5002	protein histidine kinase activity
ACG33_RS13440	COG0745	RESPONSE REGULATOR receiver
ACG33_RS13460	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACG33_RS13465	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ACG33_RS13480	COG2217	Heavy metal translocating P-type atpase
ACG33_RS13495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACG33_RS13505	COG0058	SHG alpha-glucan phosphorylase activity
ACG33_RS13530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACG33_RS13535	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACG33_RS13555	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACG33_RS13560	COG0789	Transcriptional regulator
ACG33_RS13580	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACG33_RS13585	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ACG33_RS13600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACG33_RS13605	COG2217	Heavy metal translocating P-type atpase
ACG33_RS13610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACG33_RS13635	COG0431	NADPH-dependent FMN reductase
ACG33_RS13650	COG0798	PFAM Bile acid sodium symporter
ACG33_RS13655	COG0653	protein targeting
ACG33_RS13715	COG0667	Aldo Keto reductase
ACG33_RS13730	COG0789	Transcriptional regulator
ACG33_RS13795	COG0583	DNA-binding transcription factor activity
ACG33_RS13800	COG1396	sequence-specific DNA binding
ACG33_RS13810	COG0582	viral genome integration into host DNA
ACG33_RS13835	COG2211	Major facilitator Superfamily
ACG33_RS13840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACG33_RS13850	COG0756	dUTP diphosphatase activity
ACG33_RS13855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACG33_RS13860	COG2003	Belongs to the UPF0758 family
ACG33_RS13865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACG33_RS13870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACG33_RS13875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACG33_RS13890	COG0742	ribosomal rna small subunit methyltransferase
ACG33_RS13895	COG0552	protein localization to endoplasmic reticulum
ACG33_RS13900	COG2884	Cell division ATP-binding protein ftsE
ACG33_RS13905	COG2177	Part of the ABC transporter FtsEX involved in
ACG33_RS13915	COG2885	chlorophyll binding
ACG33_RS13920	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS13950	COG0612	Peptidase, M16
ACG33_RS13965	COG0180	Tryptophanyl-tRNA synthetase
ACG33_RS13980	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS13995	COG0488	(ABC) transporter
ACG33_RS14005	COG4251	negative regulation of phosphorylation
ACG33_RS14020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACG33_RS14035	COG2974	May be involved in recombination
ACG33_RS14050	COG1127	ABC transporter
ACG33_RS14055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACG33_RS14060	COG0668	transmembrane transport
ACG33_RS14065	COG0039	L-malate dehydrogenase activity
ACG33_RS14070	COG1960	acyl-CoA dehydrogenase activity
ACG33_RS14075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACG33_RS14090	COG2816	NAD+ diphosphatase activity
ACG33_RS14105	COG0729	surface antigen
ACG33_RS14110	COG2911	Protein conserved in bacteria
ACG33_RS14115	COG1051	belongs to the nudix hydrolase family
ACG33_RS14125	COG1438	arginine binding
ACG33_RS14130	COG0137	argininosuccinate synthase activity
ACG33_RS14140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACG33_RS14150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACG33_RS14155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACG33_RS14160	COG0165	Argininosuccinate lyase
ACG33_RS14165	COG2050	protein possibly involved in aromatic compounds catabolism
ACG33_RS14180	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACG33_RS14215	COG2201	protein-glutamate methylesterase activity
ACG33_RS14230	COG0612	Peptidase, M16
ACG33_RS14255	COG0784	Response regulator, receiver
ACG33_RS14270	COG1640	4-alpha-glucanotransferase
ACG33_RS14280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACG33_RS14285	COG0058	SHG alpha-glucan phosphorylase activity
ACG33_RS14295	COG2373	Large extracellular alpha-helical protein
ACG33_RS14300	COG4953	penicillin-binding protein 1C
ACG33_RS14330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACG33_RS14335	COG2766	serine protein kinase
ACG33_RS14340	COG2718	Belongs to the UPF0229 family
ACG33_RS14345	COG2719	SpoVR family
ACG33_RS14350	COG1201	RNA secondary structure unwinding
ACG33_RS14365	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACG33_RS14380	COG0583	DNA-binding transcription factor activity
ACG33_RS14385	COG0400	carboxylic ester hydrolase activity
ACG33_RS14390	COG0442	prolyl-tRNA aminoacylation
ACG33_RS14415	COG4181	ATPase activity
ACG33_RS14425	COG0318	PFAM AMP-dependent synthetase and ligase
ACG33_RS14430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACG33_RS14435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACG33_RS14440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACG33_RS14445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACG33_RS14500	COG0254	rRNA binding
ACG33_RS14505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACG33_RS14510	COG0129	dihydroxy-acid dehydratase activity
ACG33_RS14520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACG33_RS14525	COG0631	protein serine/threonine phosphatase activity
ACG33_RS14530	COG1561	YicC-like family, N-terminal region
ACG33_RS14550	COG0194	GDP metabolic process
ACG33_RS14560	COG2151	metal-sulfur cluster biosynthetic enzyme
ACG33_RS14595	COG0445	tRNA wobble uridine modification
ACG33_RS14600	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
ACG33_RS14610	COG1309	transcriptional regulator
ACG33_RS14640	COG0435	Glutathione S-transferase
ACG33_RS14650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACG33_RS14655	COG3177	Filamentation induced by cAMP protein fic
ACG33_RS14665	COG3609	addiction module antidote protein, CC2985 family
ACG33_RS14700	COG3245	cytochrome
ACG33_RS14715	COG0004	ammonium transporteR
ACG33_RS14725	COG3275	phosphorelay sensor kinase activity
ACG33_RS14750	COG0181	hydroxymethylbilane synthase activity
ACG33_RS14780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACG33_RS14790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACG33_RS14800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACG33_RS14820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACG33_RS14825	COG0586	Pfam SNARE associated Golgi protein
ACG33_RS14830	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACG33_RS14840	COG0159	tryptophan synthase activity
ACG33_RS14845	COG0133	tryptophan synthase activity
ACG33_RS14850	COG0135	phosphoribosylanthranilate isomerase activity
ACG33_RS14855	COG0134	indole-3-glycerol-phosphate synthase activity
ACG33_RS14860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACG33_RS14870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACG33_RS14880	COG1028	Short-chain dehydrogenase reductase Sdr
ACG33_RS14880	COG0604	alcohol dehydrogenase
ACG33_RS14880	COG3321	synthase
ACG33_RS14885	COG0745	RESPONSE REGULATOR receiver
ACG33_RS14890	COG5002	protein histidine kinase activity
ACG33_RS14895	COG4208	sulfate ABC transporter
ACG33_RS14905	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ACG33_RS14910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACG33_RS14930	COG0583	DNA-binding transcription factor activity
ACG33_RS14950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACG33_RS14950	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACG33_RS14955	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACG33_RS14965	COG0584	glycerophosphoryl diester phosphodiesterase
ACG33_RS14990	COG0513	Belongs to the DEAD box helicase family
ACG33_RS15000	COG0242	peptide deformylase activity
ACG33_RS15005	COG2814	Major facilitator Superfamily
ACG33_RS15015	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACG33_RS15020	COG0577	efflux transmembrane transporter activity
ACG33_RS15020	COG1136	(ABC) transporter
ACG33_RS15025	COG0577	efflux transmembrane transporter activity
ACG33_RS15025	COG1136	(ABC) transporter
ACG33_RS15030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACG33_RS15040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACG33_RS15050	COG1047	Peptidyl-prolyl cis-trans
ACG33_RS15055	COG0708	Exodeoxyribonuclease III
ACG33_RS15070	COG4774	siderophore transport
ACG33_RS15090	COG0517	IMP dehydrogenase activity
ACG33_RS15095	COG1335	isochorismatase
ACG33_RS15105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACG33_RS15125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACG33_RS15130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACG33_RS15135	COG1492	cobalamin metabolic process
ACG33_RS15140	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACG33_RS15145	COG1120	ATPase activity
ACG33_RS15150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACG33_RS15165	COG4206	TonB-dependent receptor
ACG33_RS15175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACG33_RS15180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACG33_RS15185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACG33_RS15190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACG33_RS15195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACG33_RS15200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACG33_RS15205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACG33_RS15210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACG33_RS15225	COG0356	it plays a direct role in the translocation of protons across the membrane
ACG33_RS15240	COG1475	DNA binding
ACG33_RS15245	COG1192	Involved in chromosome partitioning
ACG33_RS15250	COG0357	Ribosomal RNA small subunit methyltransferase G
ACG33_RS15255	COG0604	alcohol dehydrogenase
ACG33_RS15265	COG1758	RNA polymerase activity
ACG33_RS15270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACG33_RS15280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACG33_RS15285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACG33_RS15290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACG33_RS15310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACG33_RS15320	COG1845	cytochrome c oxidase, subunit III
ACG33_RS15355	COG0210	DNA helicase
ACG33_RS15360	COG0569	domain protein
ACG33_RS15365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACG33_RS15370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACG33_RS15380	COG1490	D-aminoacyl-tRNA deacylase activity
ACG33_RS15390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACG33_RS15395	COG0805	protein transport
ACG33_RS15405	COG1297	OPT oligopeptide transporter protein
ACG33_RS15410	COG1950	PFAM Membrane protein of
ACG33_RS15415	COG0793	Belongs to the peptidase S41A family
ACG33_RS15420	COG4942	peptidase
ACG33_RS15430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACG33_RS15440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACG33_RS15445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACG33_RS15450	COG0167	dihydroorotate dehydrogenase activity
ACG33_RS15460	COG3852	Histidine kinase
ACG33_RS15470	COG0174	glutamine synthetase
ACG33_RS15480	COG0751	glycine-tRNA ligase activity
ACG33_RS15490	COG0187	DNA topoisomerase II activity
ACG33_RS15505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACG33_RS15510	COG0594	ribonuclease P activity
ACG33_RS15515	COG0706	membrane insertase activity