locus-tag	class	description
EL335_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EL335_RS00010	COG0592	DNA-directed DNA polymerase activity
EL335_RS00025	COG2204	response regulator
EL335_RS00030	COG3852	Histidine kinase
EL335_RS00050	COG0243	molybdopterin cofactor binding
EL335_RS00090	COG4191	Histidine kinase
EL335_RS00105	COG0243	molybdopterin cofactor binding
EL335_RS00130	COG0243	molybdopterin cofactor binding
EL335_RS00135	COG0437	4 iron, 4 sulfur cluster binding
EL335_RS00155	COG0446	pyridine nucleotide-disulphide oxidoreductase
EL335_RS00160	COG0425	Belongs to the sulfur carrier protein TusA family
EL335_RS00175	COG0798	PFAM Bile acid sodium symporter
EL335_RS00190	COG3385	transposase activity
EL335_RS00200	COG2814	Major facilitator Superfamily
EL335_RS00215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EL335_RS00225	COG0037	tRNA processing
EL335_RS00240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EL335_RS00245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EL335_RS00250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EL335_RS00305	COG4232	protein-disulfide reductase activity
EL335_RS00315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EL335_RS00335	COG0022	dehydrogenase e1 component
EL335_RS00350	COG1131	(ABC) transporter
EL335_RS00355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EL335_RS00360	COG1970	mechanosensitive ion channel activity
EL335_RS00365	COG1702	phosphate starvation-inducible protein PhoH
EL335_RS00370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EL335_RS00375	COG4535	Mg2 and Co2 transporter CorC
EL335_RS00380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EL335_RS00385	COG0752	glycyl-tRNA synthetase alpha subunit
EL335_RS00390	COG0751	glycine-tRNA ligase activity
EL335_RS00395	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EL335_RS00450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EL335_RS00460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EL335_RS00465	COG0154	amidase activity
EL335_RS00470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EL335_RS00475	COG1077	Cell shape determining protein MreB Mrl
EL335_RS00485	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EL335_RS00490	COG0768	penicillin binding
EL335_RS00495	COG0772	Belongs to the SEDS family
EL335_RS00505	COG1686	Belongs to the peptidase S11 family
EL335_RS00510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EL335_RS00515	COG2921	Belongs to the UPF0250 family
EL335_RS00520	COG0321	lipoyl(octanoyl) transferase activity
EL335_RS00525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EL335_RS00530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EL335_RS00530	COG0438	transferase activity, transferring glycosyl groups
EL335_RS00535	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EL335_RS00540	COG0438	transferase activity, transferring glycosyl groups
EL335_RS00560	COG0745	RESPONSE REGULATOR receiver
EL335_RS00575	COG0573	inorganic phosphate transmembrane transporter activity
EL335_RS00595	COG0210	DNA helicase
EL335_RS00600	COG0617	tRNA 3'-terminal CCA addition
EL335_RS00610	COG0741	lytic transglycosylase activity
EL335_RS00615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EL335_RS00620	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EL335_RS00630	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EL335_RS00640	COG0840	transmembrane signaling receptor activity
EL335_RS00645	COG2201	protein-glutamate methylesterase activity
EL335_RS00660	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EL335_RS00670	COG0612	Peptidase, M16
EL335_RS00675	COG0612	Peptidase, M16
EL335_RS00705	COG0742	ribosomal rna small subunit methyltransferase
EL335_RS00710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EL335_RS00715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EL335_RS00720	COG0861	Integral membrane protein TerC family
EL335_RS00725	COG0589	response to stress
EL335_RS00730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EL335_RS00740	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EL335_RS00745	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EL335_RS00750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EL335_RS00755	COG1321	iron dependent repressor
EL335_RS00770	COG1640	4-alpha-glucanotransferase
EL335_RS00780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EL335_RS00790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EL335_RS00795	COG0511	ligase activity, forming carbon-carbon bonds
EL335_RS00800	COG0439	Biotin carboxylase
EL335_RS00805	COG2264	protein methyltransferase activity
EL335_RS00815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EL335_RS00845	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EL335_RS00850	COG1518	maintenance of DNA repeat elements
EL335_RS00855	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EL335_RS00900	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EL335_RS00905	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EL335_RS00930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EL335_RS00935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EL335_RS00945	COG3568	Endonuclease Exonuclease Phosphatase
EL335_RS00955	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EL335_RS00960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EL335_RS00965	COG0174	glutamine synthetase
EL335_RS00975	COG3852	Histidine kinase
EL335_RS00990	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EL335_RS00990	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EL335_RS00995	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EL335_RS01100	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
EL335_RS01105	COG0237	dephospho-CoA kinase activity
EL335_RS01110	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EL335_RS01115	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EL335_RS01120	COG0494	nUDIX hydrolase
EL335_RS01130	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EL335_RS01140	COG0004	ammonium transporteR
EL335_RS01150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EL335_RS01160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EL335_RS01165	COG1238	metal cluster binding
EL335_RS01180	COG1902	pentaerythritol trinitrate reductase activity
EL335_RS01190	COG0432	Pfam Uncharacterised protein family UPF0047
EL335_RS01195	COG0367	asparagine synthase
EL335_RS01200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EL335_RS01250	COG0783	Belongs to the Dps family
EL335_RS01265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EL335_RS01275	COG3243	poly(R)-hydroxyalkanoic acid synthase
EL335_RS01290	COG1960	acyl-CoA dehydrogenase activity
EL335_RS01295	COG0183	Belongs to the thiolase family
EL335_RS01300	COG0697	spore germination
EL335_RS01305	COG1960	acyl-CoA dehydrogenase activity
EL335_RS01310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EL335_RS01320	COG4770	biotin carboxylase activity
EL335_RS01335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EL335_RS01340	COG3161	chorismate lyase activity
EL335_RS01345	COG1660	Displays ATPase and GTPase activities
EL335_RS01380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EL335_RS01395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EL335_RS01410	COG4636	protein conserved in cyanobacteria
EL335_RS01420	COG0859	PFAM glycosyl transferase family 9
EL335_RS01430	COG0438	transferase activity, transferring glycosyl groups
EL335_RS01450	COG0438	transferase activity, transferring glycosyl groups
EL335_RS01460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EL335_RS01465	COG0438	transferase activity, transferring glycosyl groups
EL335_RS01470	COG1132	(ABC) transporter
EL335_RS01475	COG0859	PFAM glycosyl transferase family 9
EL335_RS01480	COG0438	transferase activity, transferring glycosyl groups
EL335_RS01495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EL335_RS01500	COG3338	carbonate dehydratase activity
EL335_RS01505	COG1194	a g-specific adenine glycosylase
EL335_RS01515	COG0142	geranyltranstransferase activity
EL335_RS01525	COG4251	negative regulation of phosphorylation
EL335_RS01530	COG0784	Response regulator, receiver
EL335_RS01545	COG0840	transmembrane signaling receptor activity
EL335_RS01550	COG5001	Diguanylate cyclase
EL335_RS01550	COG5002	protein histidine kinase activity
EL335_RS01570	COG3023	N-Acetylmuramoyl-L-alanine amidase
EL335_RS01585	COG0436	Aminotransferase
EL335_RS01590	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EL335_RS01595	COG0281	malic enzyme
EL335_RS01595	COG0280	phosphate acetyltransferase
EL335_RS01600	COG1686	Belongs to the peptidase S11 family
EL335_RS01605	COG0247	lactate metabolic process
EL335_RS01610	COG1139	Iron-sulfur cluster binding protein
EL335_RS01645	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EL335_RS01670	COG0475	glutathione-regulated potassium exporter activity
EL335_RS01680	COG2271	Major facilitator Superfamily
EL335_RS01715	COG0436	Aminotransferase
EL335_RS01720	COG0488	(ABC) transporter
EL335_RS01745	COG0284	orotidine-5'-phosphate decarboxylase activity
EL335_RS01750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EL335_RS01755	COG1643	Atp-dependent helicase
EL335_RS01765	COG1546	Belongs to the CinA family
EL335_RS01765	COG1058	Belongs to the CinA family
EL335_RS01770	COG0577	efflux transmembrane transporter activity
EL335_RS01770	COG1136	(ABC) transporter
EL335_RS01775	COG4591	ABC-type transport system involved in lipoprotein release permease component
EL335_RS01775	COG1136	(ABC) transporter
EL335_RS01785	COG2165	general secretion pathway protein
EL335_RS01790	COG2165	general secretion pathway protein
EL335_RS01800	COG1459	type II secretion system
EL335_RS01805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EL335_RS01810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EL335_RS01815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EL335_RS01825	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EL335_RS01830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EL335_RS01835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EL335_RS01840	COG0640	Transcriptional regulator
EL335_RS01845	COG0588	phosphoglycerate mutase activity
EL335_RS01850	COG4942	peptidase
EL335_RS01855	COG0793	Belongs to the peptidase S41A family
EL335_RS01865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EL335_RS01870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EL335_RS01870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EL335_RS01875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EL335_RS01880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EL335_RS01900	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EL335_RS01905	COG0312	modulator of DNA gyrase
EL335_RS01910	COG3028	Belongs to the UPF0307 family
EL335_RS01915	COG0521	Mo-molybdopterin cofactor biosynthetic process
EL335_RS01920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EL335_RS01925	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EL335_RS01930	COG0837	glucose binding
EL335_RS01940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EL335_RS01950	COG0166	Belongs to the GPI family
EL335_RS01955	COG0297	glycogen (starch) synthase activity
EL335_RS01970	COG0717	Belongs to the dCTP deaminase family
EL335_RS01975	COG0489	protein tyrosine kinase activity
EL335_RS01980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EL335_RS01980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EL335_RS01985	COG1254	Belongs to the acylphosphatase family
EL335_RS02000	COG0737	Belongs to the 5'-nucleotidase family
EL335_RS02005	COG2010	Cytochrome c
EL335_RS02030	COG1595	DNA-templated transcription, initiation
EL335_RS02050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EL335_RS02055	COG0602	queuosine metabolic process
EL335_RS02070	COG0823	Involved in the tonB-independent uptake of proteins
EL335_RS02090	COG0824	Thioesterase
EL335_RS02095	COG2255	four-way junction helicase activity
EL335_RS02100	COG0628	permease
EL335_RS02105	COG0632	four-way junction helicase activity
EL335_RS02110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EL335_RS02115	COG0217	transcriptional regulatory protein
EL335_RS02125	COG0433	COG0433 Predicted ATPase
EL335_RS02150	COG4771	TonB-dependent receptor
EL335_RS02165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EL335_RS02185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EL335_RS02190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EL335_RS02200	COG1560	Kdo2-lipid A biosynthetic process
EL335_RS02205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EL335_RS02215	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EL335_RS02235	COG0577	efflux transmembrane transporter activity
EL335_RS02235	COG1136	(ABC) transporter
EL335_RS02260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EL335_RS02270	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EL335_RS02275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EL335_RS02290	COG1965	Belongs to the frataxin family
EL335_RS02325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EL335_RS02330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EL335_RS02335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EL335_RS02340	COG0070	glutamate synthase
EL335_RS02340	COG0069	glutamate synthase activity
EL335_RS02340	COG0067	glutamate synthase
EL335_RS02350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EL335_RS02385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EL335_RS02385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EL335_RS02385	COG1703	isobutyryl-CoA mutase activity
EL335_RS02390	COG0473	3-isopropylmalate dehydrogenase activity
EL335_RS02395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EL335_RS02400	COG0066	3-isopropylmalate dehydratase activity
EL335_RS02405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EL335_RS02425	COG1022	Amp-dependent synthetase and ligase
EL335_RS02480	COG2197	response regulator
EL335_RS02490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EL335_RS02495	COG0277	FAD linked oxidase domain protein
EL335_RS02525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EL335_RS02540	COG0081	regulation of translation
EL335_RS02545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EL335_RS02550	COG0222	ribosome binding
EL335_RS02555	COG0085	RNA polymerase activity
EL335_RS02560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EL335_RS02565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EL335_RS02570	COG0049	tRNA binding
EL335_RS02575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EL335_RS02585	COG0051	transcription antitermination factor activity, RNA binding
EL335_RS02590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EL335_RS02595	COG0088	Forms part of the polypeptide exit tunnel
EL335_RS02600	COG0089	rRNA binding
EL335_RS02605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EL335_RS02610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EL335_RS02615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EL335_RS02620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EL335_RS02625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EL335_RS02630	COG0255	Belongs to the universal ribosomal protein uL29 family
EL335_RS02635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EL335_RS02640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EL335_RS02645	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EL335_RS02650	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EL335_RS02655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EL335_RS02660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EL335_RS02665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EL335_RS02670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EL335_RS02675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EL335_RS02680	COG1841	ribosomal large subunit assembly
EL335_RS02685	COG0200	Binds to the 23S rRNA
EL335_RS02690	COG0201	protein transport
EL335_RS02700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EL335_RS02705	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EL335_RS02710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EL335_RS02715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EL335_RS02720	COG0202	RNA polymerase activity
EL335_RS02725	COG0203	ribosomal protein L17
EL335_RS02730	COG2840	Smr protein MutS2
EL335_RS02735	COG0492	ferredoxin-NADP+ reductase activity
EL335_RS02740	COG1674	ftsk spoiiie
EL335_RS02745	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EL335_RS02750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EL335_RS02755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EL335_RS02760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EL335_RS02770	COG2920	part of a sulfur-relay system
EL335_RS02775	COG1032	radical SAM domain protein
EL335_RS02805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EL335_RS02815	COG0840	transmembrane signaling receptor activity
EL335_RS02820	COG0784	Response regulator, receiver
EL335_RS02820	COG0835	chemotaxis
EL335_RS02825	COG0784	Response regulator, receiver
EL335_RS02825	COG0835	chemotaxis
EL335_RS02835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EL335_RS02840	COG2198	Histidine kinase
EL335_RS02840	COG0643	Histidine kinase
EL335_RS02840	COG0784	Response regulator, receiver
EL335_RS02870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EL335_RS02875	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EL335_RS02895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EL335_RS02900	COG1360	Flagellar Motor Protein
EL335_RS02920	COG1815	bacterial-type flagellum-dependent cell motility
EL335_RS02925	COG1558	bacterial-type flagellum-dependent cell motility
EL335_RS02930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EL335_RS02935	COG1749	Flagellar hook protein flgE
EL335_RS02950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EL335_RS02955	COG1706	bacterial-type flagellum-dependent cell motility
EL335_RS02960	COG1705	Flagellar rod assembly protein muramidase FlgJ
EL335_RS02960	COG3951	Flagellar rod assembly protein muramidase FlgJ
EL335_RS02975	COG2226	methyltransferase
EL335_RS02980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EL335_RS02995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EL335_RS03005	COG5443	negative regulation of bacterial-type flagellum assembly
EL335_RS03035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EL335_RS03040	COG4310	Domain of unknown function (DUF2172)
EL335_RS03045	COG1256	bacterial-type flagellum assembly
EL335_RS03055	COG1086	Polysaccharide biosynthesis protein
EL335_RS03060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EL335_RS03075	COG2089	acid synthase
EL335_RS03110	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EL335_RS03160	COG1677	Flagellar hook-basal body complex protein FliE
EL335_RS03165	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EL335_RS03185	COG1028	Short-chain dehydrogenase reductase Sdr
EL335_RS03200	COG2358	TRAP transporter, solute receptor (TAXI family
EL335_RS03220	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EL335_RS03225	COG0501	Belongs to the peptidase M48B family
EL335_RS03230	COG0583	DNA-binding transcription factor activity
EL335_RS03250	COG0277	FAD linked oxidase domain protein
EL335_RS03255	COG1752	Esterase of the alpha-beta hydrolase superfamily
EL335_RS03260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EL335_RS03270	COG3243	poly(R)-hydroxyalkanoic acid synthase
EL335_RS03280	COG0564	pseudouridine synthase activity
EL335_RS03290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EL335_RS03305	COG0557	exoribonuclease II activity
EL335_RS03320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EL335_RS03330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EL335_RS03355	COG0732	type I restriction modification DNA specificity domain
EL335_RS03370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EL335_RS03400	COG0482	sulfurtransferase activity
EL335_RS03405	COG0625	glutathione transferase activity
EL335_RS03430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EL335_RS03435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EL335_RS03440	COG1862	Preprotein translocase
EL335_RS03445	COG0343	queuine tRNA-ribosyltransferase activity
EL335_RS03450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EL335_RS03475	COG3259	Nickel-dependent hydrogenase
EL335_RS03480	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
EL335_RS03485	COG3383	formate dehydrogenase (NAD+) activity
EL335_RS03490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EL335_RS03545	COG0409	Hydrogenase expression formation protein
EL335_RS03550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EL335_RS03550	COG1024	Enoyl-CoA hydratase
EL335_RS03555	COG2204	response regulator
EL335_RS03575	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EL335_RS03580	COG0437	4 iron, 4 sulfur cluster binding
EL335_RS03585	COG5557	Pfam Polysulphide reductase, NrfD
EL335_RS03590	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EL335_RS03595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EL335_RS03605	COG0375	protein maturation
EL335_RS03615	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EL335_RS03630	COG0501	Belongs to the peptidase M48B family
EL335_RS03635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EL335_RS03645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EL335_RS03650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EL335_RS03665	COG0708	Exodeoxyribonuclease III
EL335_RS03670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EL335_RS03680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EL335_RS03695	COG0739	heme binding
EL335_RS03700	COG0653	protein targeting
EL335_RS03705	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EL335_RS03710	COG0235	Class ii aldolase
EL335_RS03715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EL335_RS03720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EL335_RS03725	COG0505	Belongs to the CarA family
EL335_RS03730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EL335_RS03735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EL335_RS03740	COG0735	belongs to the Fur family
EL335_RS03755	COG2151	metal-sulfur cluster biosynthetic enzyme
EL335_RS03770	COG2181	nitrate reductase activity
EL335_RS03775	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EL335_RS03780	COG1140	nitrate reductase beta subunit
EL335_RS03785	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EL335_RS03800	COG2197	response regulator
EL335_RS03805	COG3850	Histidine kinase
EL335_RS03825	COG1136	(ABC) transporter
EL335_RS03850	COG2161	toxin-antitoxin pair type II binding
EL335_RS03855	COG4115	mRNA cleavage
EL335_RS03875	COG1845	cytochrome c oxidase, subunit III
EL335_RS03890	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EL335_RS03900	COG0318	PFAM AMP-dependent synthetase and ligase
EL335_RS03915	COG5002	protein histidine kinase activity
EL335_RS03915	COG5001	Diguanylate cyclase
EL335_RS03940	COG1575	Belongs to the MenA family. Type 1 subfamily
EL335_RS03945	COG2226	methyltransferase
EL335_RS03950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EL335_RS03965	COG1116	anion transmembrane transporter activity
EL335_RS03980	COG0348	domain, Protein
EL335_RS03985	COG0437	4 iron, 4 sulfur cluster binding
EL335_RS04005	COG2863	cytochrome
EL335_RS04010	COG4263	nitrous-oxide reductase activity
EL335_RS04015	COG2197	response regulator
EL335_RS04025	COG4263	nitrous-oxide reductase activity
EL335_RS04035	COG1162	GTPase activity
EL335_RS04040	COG2154	pterin-4-alpha-carbinolamine dehydratase
EL335_RS04045	COG0501	Belongs to the peptidase M48B family
EL335_RS04050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EL335_RS04060	COG0254	rRNA binding
EL335_RS04065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EL335_RS04075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EL335_RS04080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EL335_RS04090	COG0617	tRNA 3'-terminal CCA addition
EL335_RS04110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EL335_RS04115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EL335_RS04120	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EL335_RS04125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EL335_RS04135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EL335_RS04140	COG0586	Pfam SNARE associated Golgi protein
EL335_RS04150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EL335_RS04160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EL335_RS04160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EL335_RS04170	COG3264	Mechanosensitive ion channel
EL335_RS04170	COG1511	domain protein
EL335_RS04185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EL335_RS04190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EL335_RS04195	COG2003	Belongs to the UPF0758 family
EL335_RS04200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EL335_RS04205	COG0756	dUTP diphosphatase activity
EL335_RS04210	COG0446	pyridine nucleotide-disulphide oxidoreductase
EL335_RS04215	COG2863	cytochrome
EL335_RS04225	COG3005	denitrification pathway
EL335_RS04230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EL335_RS04240	COG0583	DNA-binding transcription factor activity
EL335_RS04245	COG2224	Isocitrate lyase
EL335_RS04250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EL335_RS04255	COG0542	response to heat
EL335_RS04260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EL335_RS04265	COG1278	Cold shock
EL335_RS04270	COG0538	isocitrate dehydrogenase activity
EL335_RS04275	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EL335_RS04295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EL335_RS04300	COG1278	Cold shock
EL335_RS04310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EL335_RS04315	COG1570	exodeoxyribonuclease VII activity
EL335_RS04345	COG1122	ATPase activity
EL335_RS04355	COG0310	cobalt ion transport
EL335_RS04390	COG1573	uracil-dna glycosylase
EL335_RS04395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EL335_RS04400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EL335_RS04405	COG4942	peptidase
EL335_RS04405	COG1388	LysM domain
EL335_RS04415	COG2951	lytic endotransglycosylase activity
EL335_RS04430	COG0714	Associated with various cellular activities
EL335_RS04435	COG0123	including yeast histone deacetylase and acetoin utilization protein
EL335_RS04440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EL335_RS04445	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EL335_RS04450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EL335_RS04460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EL335_RS04470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EL335_RS04480	COG1217	gtp-binding protein TYPA
EL335_RS04490	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EL335_RS04495	COG0024	Methionine aminopeptidase
EL335_RS04500	COG0052	Belongs to the universal ribosomal protein uS2 family
EL335_RS04505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EL335_RS04510	COG0528	UMP kinase activity
EL335_RS04515	COG0233	cytoplasmic translational termination
EL335_RS04520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EL335_RS04530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EL335_RS04540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EL335_RS04550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EL335_RS04555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EL335_RS04560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EL335_RS04565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EL335_RS04570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EL335_RS04575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EL335_RS04590	COG0583	DNA-binding transcription factor activity
EL335_RS04595	COG0730	response to heat
EL335_RS04610	COG0175	sulfate reduction
EL335_RS04620	COG2895	sulfate adenylyltransferase (ATP) activity
EL335_RS04625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EL335_RS04630	COG2867	negative regulation of translational initiation
EL335_RS04635	COG2914	Belongs to the UPF0125 (RnfH) family
EL335_RS04650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EL335_RS04650	COG0519	Catalyzes the synthesis of GMP from XMP
EL335_RS04675	COG1993	acr, cog1993
EL335_RS04685	COG0303	'Molybdopterin
EL335_RS04695	COG1028	Short-chain dehydrogenase reductase Sdr
EL335_RS04710	COG2414	aldehyde ferredoxin oxidoreductase
EL335_RS04740	COG2183	response to ionizing radiation
EL335_RS04745	COG2050	protein possibly involved in aromatic compounds catabolism
EL335_RS04750	COG1309	transcriptional regulator
EL335_RS04760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EL335_RS04770	COG1923	regulation of RNA biosynthetic process
EL335_RS04775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EL335_RS04780	COG0330	HflC and HflK could
EL335_RS04785	COG0330	HflC and HflK could
EL335_RS04795	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EL335_RS04800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EL335_RS04815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EL335_RS04820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EL335_RS04840	COG0778	Nitroreductase
EL335_RS04870	COG5002	protein histidine kinase activity
EL335_RS04870	COG2176	DNA-directed DNA polymerase activity
EL335_RS04885	COG0601	transmembrane transport
EL335_RS04890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EL335_RS04900	COG0741	lytic transglycosylase activity
EL335_RS04900	COG1388	LysM domain
EL335_RS04920	COG0105	UTP biosynthetic process
EL335_RS04925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EL335_RS04935	COG1426	Protein conserved in bacteria
EL335_RS04940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EL335_RS04945	COG0124	histidyl-tRNA synthetase
EL335_RS04950	COG2976	Protein conserved in bacteria
EL335_RS04955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EL335_RS04960	COG1160	GTP binding
EL335_RS04965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EL335_RS04970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EL335_RS04980	COG2814	Major facilitator Superfamily
EL335_RS04995	COG0473	3-isopropylmalate dehydrogenase activity
EL335_RS05015	COG0101	tRNA pseudouridine synthase activity
EL335_RS05020	COG0135	phosphoribosylanthranilate isomerase activity
EL335_RS05025	COG0133	tryptophan synthase activity
EL335_RS05040	COG0159	tryptophan synthase activity
EL335_RS05045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EL335_RS05050	COG0285	dihydrofolate synthase activity
EL335_RS05080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EL335_RS05085	COG0723	plastoquinol--plastocyanin reductase activity
EL335_RS05090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EL335_RS05095	COG2857	Cytochrome c1
EL335_RS05100	COG0625	glutathione transferase activity
EL335_RS05105	COG2969	positive regulation of protein catabolic process
EL335_RS05120	COG0360	Binds together with S18 to 16S ribosomal RNA
EL335_RS05125	COG2965	DNA replication, synthesis of RNA primer
EL335_RS05130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EL335_RS05135	COG0359	binds to the 23S rRNA
EL335_RS05140	COG0305	Participates in initiation and elongation during chromosome replication
EL335_RS05145	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EL335_RS05150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EL335_RS05155	COG0726	polysaccharide deacetylase
EL335_RS05165	COG0436	Aminotransferase
EL335_RS05195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EL335_RS05205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EL335_RS05205	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EL335_RS05210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EL335_RS05240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EL335_RS05245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EL335_RS05260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EL335_RS05265	COG0271	Belongs to the BolA IbaG family
EL335_RS05270	COG2350	Protein conserved in bacteria
EL335_RS05275	COG2917	probably involved in intracellular septation
EL335_RS05280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EL335_RS05285	COG0513	Belongs to the DEAD box helicase family
EL335_RS05290	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EL335_RS05295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EL335_RS05305	COG0215	cysteine-tRNA ligase activity
EL335_RS05310	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EL335_RS05325	COG0825	malonyl-CoA metabolic process
EL335_RS05330	COG0037	tRNA processing
EL335_RS05335	COG4566	intracellular signal transduction
EL335_RS05350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EL335_RS05355	COG0488	(ABC) transporter
EL335_RS05385	COG0326	Molecular chaperone. Has ATPase activity
EL335_RS05395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EL335_RS05405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EL335_RS05415	COG4660	Part of a membrane complex involved in electron transport
EL335_RS05420	COG4659	FMN binding
EL335_RS05425	COG4658	electron transport chain
EL335_RS05435	COG2878	Part of a membrane complex involved in electron transport
EL335_RS05445	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EL335_RS05450	COG0248	Ppx GppA phosphatase
EL335_RS05455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EL335_RS05460	COG1127	ABC transporter
EL335_RS05480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EL335_RS05485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EL335_RS05500	COG4149	molybdate abc transporter
EL335_RS05520	COG2207	Transcriptional regulator
EL335_RS05535	COG3220	belongs to the UPF0276 family
EL335_RS05550	COG2199	diguanylate cyclase activity
EL335_RS05550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EL335_RS05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EL335_RS05580	COG1595	DNA-templated transcription, initiation
EL335_RS05595	COG2226	methyltransferase
EL335_RS05605	COG0789	Transcriptional regulator
EL335_RS05655	COG2391	methyltransferase activity
EL335_RS05715	COG1230	cation diffusion facilitator family transporter
EL335_RS05730	COG1136	(ABC) transporter
EL335_RS05730	COG0577	efflux transmembrane transporter activity
EL335_RS05735	COG4591	ABC-type transport system involved in lipoprotein release permease component
EL335_RS05750	COG0183	Belongs to the thiolase family
EL335_RS05760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EL335_RS05795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EL335_RS05800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EL335_RS05810	COG0356	it plays a direct role in the translocation of protons across the membrane
EL335_RS05820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EL335_RS05820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EL335_RS05825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EL335_RS05845	COG1230	cation diffusion facilitator family transporter
EL335_RS05860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EL335_RS05890	COG1309	transcriptional regulator
EL335_RS05895	COG1960	acyl-CoA dehydrogenase activity
EL335_RS05900	COG2067	long-chain fatty acid transport protein
EL335_RS05905	COG1250	3-hydroxyacyl-CoA dehydrogenase
EL335_RS05905	COG1024	Enoyl-CoA hydratase
EL335_RS05910	COG0183	Belongs to the thiolase family
EL335_RS05920	COG0318	PFAM AMP-dependent synthetase and ligase
EL335_RS05930	COG1960	acyl-CoA dehydrogenase activity
EL335_RS05940	COG0309	Hydrogenase expression formation protein (HypE)
EL335_RS05945	COG1049	propionate catabolic process, 2-methylcitrate cycle
EL335_RS05960	COG0039	L-malate dehydrogenase activity
EL335_RS05965	COG2188	Transcriptional regulator
EL335_RS05980	COG1053	succinate dehydrogenase
EL335_RS05985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EL335_RS05990	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EL335_RS05995	COG0372	Belongs to the citrate synthase family
EL335_RS06000	COG0567	Dehydrogenase, E1 component
EL335_RS06005	COG0508	dehydrogenase complex catalyzes the overall conversion of
EL335_RS06010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EL335_RS06020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EL335_RS06030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EL335_RS06035	COG2937	Belongs to the GPAT DAPAT family
EL335_RS06045	COG5001	Diguanylate cyclase
EL335_RS06045	COG3300	MHYT domain
EL335_RS06050	COG0167	dihydroorotate dehydrogenase activity
EL335_RS06055	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EL335_RS06060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EL335_RS06065	COG3842	ATPase activity
EL335_RS06070	COG1178	ABC-type Fe3 transport system permease component
EL335_RS06080	COG1840	ABC-type Fe3 transport system, periplasmic component
EL335_RS06085	COG0604	alcohol dehydrogenase
EL335_RS06090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EL335_RS06100	COG0149	triose-phosphate isomerase activity
EL335_RS06115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EL335_RS06120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EL335_RS06130	COG0649	NAD binding
EL335_RS06135	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EL335_RS06145	COG1034	ATP synthesis coupled electron transport
EL335_RS06150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EL335_RS06155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EL335_RS06165	COG0713	ATP synthesis coupled electron transport
EL335_RS06180	COG1007	ATP synthesis coupled electron transport
EL335_RS06220	COG1199	ATP-dependent helicase activity
EL335_RS06235	COG1763	Mo-molybdopterin cofactor biosynthetic process
EL335_RS06240	COG0303	'Molybdopterin
EL335_RS06245	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EL335_RS06250	COG0314	molybdopterin synthase activity
EL335_RS06280	COG2201	protein-glutamate methylesterase activity
EL335_RS06295	COG0542	response to heat
EL335_RS06315	COG2818	Glycosylase
EL335_RS06320	COG3108	Peptidase M15
EL335_RS06325	COG2989	Protein conserved in bacteria
EL335_RS06330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EL335_RS06330	COG0045	succinate-CoA ligase (ADP-forming) activity
EL335_RS06330	COG1042	CoA-binding domain protein
EL335_RS06340	COG2703	oxygen carrier activity
EL335_RS06345	COG1187	pseudouridine synthase activity
EL335_RS06365	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EL335_RS06380	COG4181	ATPase activity
EL335_RS06395	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
EL335_RS06405	COG1562	ergosterol biosynthetic process
EL335_RS06415	COG0544	peptidyl-prolyl cis-trans isomerase activity
EL335_RS06420	COG0740	serine-type endopeptidase activity
EL335_RS06425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EL335_RS06430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EL335_RS06440	COG3118	belongs to the thioredoxin family
EL335_RS06445	COG2084	Dehydrogenase
EL335_RS06450	COG1881	PFAM PEBP family protein
EL335_RS06455	COG0047	phosphoribosylformylglycinamidine synthase activity
EL335_RS06455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EL335_RS06460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EL335_RS06465	COG0746	molybdenum cofactor guanylyltransferase activity
EL335_RS06470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EL335_RS06490	COG0840	transmembrane signaling receptor activity
EL335_RS06505	COG0515	serine threonine protein kinase
EL335_RS06525	COG0084	hydrolase, TatD family'
EL335_RS06535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EL335_RS06540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EL335_RS06545	COG0354	folic acid binding
EL335_RS06570	COG0574	Belongs to the PEP-utilizing enzyme family
EL335_RS06570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EL335_RS06575	COG2974	May be involved in recombination
EL335_RS06580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EL335_RS06585	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EL335_RS06595	COG0058	SHG alpha-glucan phosphorylase activity
EL335_RS06600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EL335_RS06600	COG0189	ligase activity
EL335_RS06605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EL335_RS06605	COG0189	ligase activity
EL335_RS06610	COG1132	(ABC) transporter
EL335_RS06625	COG4191	Histidine kinase
EL335_RS06630	COG3437	response regulator, receiver
EL335_RS06635	COG3852	Histidine kinase
EL335_RS06645	COG1640	4-alpha-glucanotransferase
EL335_RS06660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EL335_RS06665	COG3385	transposase activity
EL335_RS06670	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EL335_RS06675	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EL335_RS06685	COG0776	regulation of translation
EL335_RS06695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EL335_RS06700	COG0287	Prephenate dehydrogenase
EL335_RS06705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EL335_RS06715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EL335_RS06720	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EL335_RS06730	COG0402	S-adenosylhomocysteine deaminase activity
EL335_RS06740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EL335_RS06755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EL335_RS06765	COG0527	aspartate kinase activity
EL335_RS06880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EL335_RS06890	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EL335_RS06890	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EL335_RS06895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EL335_RS06915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EL335_RS06920	COG5001	Diguanylate cyclase
EL335_RS06920	COG3300	MHYT domain
EL335_RS06925	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EL335_RS06935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EL335_RS06940	COG0583	DNA-binding transcription factor activity
EL335_RS06945	COG0477	Major facilitator Superfamily
EL335_RS06955	COG0187	DNA topoisomerase II activity
EL335_RS06970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EL335_RS06975	COG1074	ATP-dependent DNA helicase activity
EL335_RS06980	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EL335_RS06985	COG1490	D-aminoacyl-tRNA deacylase activity
EL335_RS07025	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EL335_RS07035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EL335_RS07040	COG1355	regulation of microtubule-based process
EL335_RS07060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EL335_RS07065	COG1393	Belongs to the ArsC family
EL335_RS07070	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EL335_RS07075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EL335_RS07080	COG0509	glycine decarboxylation via glycine cleavage system
EL335_RS07085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EL335_RS07085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EL335_RS07100	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EL335_RS07105	COG0148	phosphopyruvate hydratase activity
EL335_RS07120	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EL335_RS07125	COG0148	phosphopyruvate hydratase activity
EL335_RS07135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EL335_RS07150	COG0504	CTP synthase activity
EL335_RS07170	COG0322	excinuclease ABC activity
EL335_RS07220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EL335_RS07230	COG1472	Belongs to the glycosyl hydrolase 3 family
EL335_RS07235	COG0736	holo-[acyl-carrier-protein] synthase activity
EL335_RS07240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EL335_RS07245	COG1381	Involved in DNA repair and RecF pathway recombination
EL335_RS07250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EL335_RS07255	COG0571	ribonuclease III activity
EL335_RS07265	COG0681	Belongs to the peptidase S26 family
EL335_RS07270	COG0481	GTPase activity
EL335_RS07280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EL335_RS07290	COG3026	antisigma factor binding
EL335_RS07305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EL335_RS07315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EL335_RS07320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EL335_RS07325	COG1028	Short-chain dehydrogenase reductase Sdr
EL335_RS07335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EL335_RS07340	COG0416	fatty acid biosynthetic process
EL335_RS07345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EL335_RS07350	COG1399	metal-binding, possibly nucleic acid-binding protein
EL335_RS07355	COG0424	maF-like protein
EL335_RS07360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EL335_RS07370	COG0546	phosphoglycolate phosphatase activity
EL335_RS07380	COG1530	ribonuclease E activity
EL335_RS07385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EL335_RS07390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EL335_RS07395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EL335_RS07425	COG1136	(ABC) transporter
EL335_RS07465	COG1185	polyribonucleotide nucleotidyltransferase activity
EL335_RS07470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EL335_RS07475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EL335_RS07480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EL335_RS07485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EL335_RS07490	COG0195	Participates in both transcription termination and antitermination
EL335_RS07495	COG0779	Required for maturation of 30S ribosomal subunits
EL335_RS07500	COG1187	pseudouridine synthase activity
EL335_RS07505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EL335_RS07515	COG2050	protein possibly involved in aromatic compounds catabolism
EL335_RS07520	COG0180	Tryptophanyl-tRNA synthetase
EL335_RS07525	COG1994	Peptidase M50
EL335_RS07530	COG0009	L-threonylcarbamoyladenylate synthase
EL335_RS07535	COG0613	PHP domain protein
EL335_RS07540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EL335_RS07545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EL335_RS07560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EL335_RS07565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EL335_RS07575	COG0156	8-amino-7-oxononanoate synthase activity
EL335_RS07585	COG4106	trans-aconitate 2-methyltransferase activity
EL335_RS07605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EL335_RS07620	COG2171	N-acyltransferase activity
EL335_RS07630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EL335_RS07640	COG1881	PFAM PEBP family protein
EL335_RS07645	COG1187	pseudouridine synthase activity
EL335_RS07650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EL335_RS07655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EL335_RS07685	COG0556	nucleotide-excision repair
EL335_RS07705	COG0577	efflux transmembrane transporter activity
EL335_RS07710	COG1136	(ABC) transporter
EL335_RS07710	COG0577	efflux transmembrane transporter activity
EL335_RS07720	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EL335_RS07725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EL335_RS07730	COG0328	RNA-DNA hybrid ribonuclease activity
EL335_RS07740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EL335_RS07745	COG0497	DNA recombination
EL335_RS07750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EL335_RS07760	COG1420	regulation of RNA biosynthetic process
EL335_RS07765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EL335_RS07780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EL335_RS07785	COG0443	Heat shock 70 kDa protein
EL335_RS07790	COG0484	heat shock protein binding
EL335_RS07795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EL335_RS07820	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EL335_RS07825	COG0084	hydrolase, TatD family'
EL335_RS07840	COG0443	Heat shock 70 kDa protein
EL335_RS07845	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EL335_RS07855	COG0822	iron-sulfur transferase activity
EL335_RS07860	COG1104	cysteine desulfurase activity
EL335_RS07875	COG1045	serine acetyltransferase
EL335_RS07885	COG0483	inositol monophosphate 1-phosphatase activity
EL335_RS07890	COG3706	GGDEF domain
EL335_RS07910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EL335_RS07910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EL335_RS07930	COG0662	Cupin 2, conserved barrel domain protein
EL335_RS07930	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EL335_RS07965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EL335_RS08020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EL335_RS08030	COG2244	polysaccharide biosynthetic process
EL335_RS08050	COG0438	transferase activity, transferring glycosyl groups
EL335_RS08100	COG0367	asparagine synthase
EL335_RS08115	COG0438	transferase activity, transferring glycosyl groups
EL335_RS08120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EL335_RS08160	COG3267	Type II secretory pathway component ExeA
EL335_RS08160	COG3409	Peptidoglycan-binding domain 1 protein
EL335_RS08170	COG0489	protein tyrosine kinase activity
EL335_RS08195	COG4191	Histidine kinase
EL335_RS08200	COG2204	response regulator
EL335_RS08210	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EL335_RS08215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EL335_RS08240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EL335_RS08245	COG0577	efflux transmembrane transporter activity
EL335_RS08250	COG1136	(ABC) transporter
EL335_RS08250	COG0577	efflux transmembrane transporter activity
EL335_RS08280	COG1136	(ABC) transporter
EL335_RS08290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EL335_RS08295	COG2197	response regulator
EL335_RS08300	COG3850	Histidine kinase
EL335_RS08305	COG0494	nUDIX hydrolase
EL335_RS08315	COG0183	Belongs to the thiolase family
EL335_RS08320	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EL335_RS08340	COG1666	GTP binding
EL335_RS08345	COG3123	guanosine phosphorylase activity
EL335_RS08355	COG0137	argininosuccinate synthase activity
EL335_RS08360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EL335_RS08365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EL335_RS08370	COG0268	Binds directly to 16S ribosomal RNA
EL335_RS08380	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EL335_RS08385	COG0205	6-phosphofructokinase activity
EL335_RS08390	COG0563	adenylate kinase activity
EL335_RS08395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EL335_RS08400	COG2835	tetraacyldisaccharide 4'-kinase activity
EL335_RS08405	COG1663	tetraacyldisaccharide 4'-kinase activity
EL335_RS08410	COG0848	biopolymer transport protein
EL335_RS08415	COG0811	peptide transport
EL335_RS08455	COG2221	Nitrite and sulphite reductase 4Fe-4S
EL335_RS08460	COG2221	Nitrite and sulphite reductase 4Fe-4S
EL335_RS08465	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EL335_RS08470	COG2923	Belongs to the DsrF TusC family
EL335_RS08480	COG2920	part of a sulfur-relay system
EL335_RS08515	COG1797	cobyrinic acid a,c-diamide synthase activity
EL335_RS08525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EL335_RS08525	COG1648	precorrin-2 dehydrogenase activity
EL335_RS08565	COG4969	Belongs to the N-Me-Phe pilin family
EL335_RS08575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EL335_RS08580	COG1047	Peptidyl-prolyl cis-trans
EL335_RS08585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EL335_RS08590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EL335_RS08595	COG0196	riboflavin kinase activity
EL335_RS08600	COG0860	N-Acetylmuramoyl-L-alanine amidase
EL335_RS08605	COG0802	atpase or kinase
EL335_RS08640	COG1722	exodeoxyribonuclease VII activity
EL335_RS08645	COG0142	geranyltranstransferase activity
EL335_RS08650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EL335_RS08655	COG1469	GTP cyclohydrolase I activity
EL335_RS08665	COG0335	large ribosomal subunit rRNA binding
EL335_RS08670	COG0336	Belongs to the RNA methyltransferase TrmD family
EL335_RS08675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EL335_RS08680	COG0228	four-way junction DNA binding
EL335_RS08685	COG2890	protein-(glutamine-N5) methyltransferase activity
EL335_RS08690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EL335_RS08695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EL335_RS08715	COG1136	(ABC) transporter
EL335_RS08715	COG0577	efflux transmembrane transporter activity
EL335_RS08725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EL335_RS08760	COG4771	TonB-dependent receptor
EL335_RS08815	COG1858	cytochrome C peroxidase
EL335_RS08840	COG2226	methyltransferase
EL335_RS08850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EL335_RS08850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EL335_RS08855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EL335_RS08865	COG2217	Heavy metal translocating P-type atpase
EL335_RS08875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EL335_RS08880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EL335_RS08885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EL335_RS08910	COG3243	poly(R)-hydroxyalkanoic acid synthase
EL335_RS08935	COG0348	domain, Protein
EL335_RS08955	COG3278	Belongs to the heme-copper respiratory oxidase family
EL335_RS08985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EL335_RS08990	COG4636	protein conserved in cyanobacteria
EL335_RS09055	COG5002	protein histidine kinase activity
EL335_RS09065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EL335_RS09080	COG0446	pyridine nucleotide-disulphide oxidoreductase
EL335_RS09095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EL335_RS09095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EL335_RS09100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EL335_RS09105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EL335_RS09135	COG0583	DNA-binding transcription factor activity
EL335_RS09160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EL335_RS09170	COG0642	Histidine kinase
EL335_RS09190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EL335_RS09200	COG0459	protein refolding
EL335_RS09205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EL335_RS09225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EL335_RS09230	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EL335_RS09235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EL335_RS09260	COG5265	(ABC) transporter
EL335_RS09265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EL335_RS09270	COG0765	amino acid transport
EL335_RS09275	COG0765	amino acid transport
EL335_RS09280	COG1126	abc transporter atp-binding protein
EL335_RS09295	COG0776	regulation of translation
EL335_RS09300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EL335_RS09300	COG0072	phenylalanine-tRNA ligase activity
EL335_RS09305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EL335_RS09310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EL335_RS09315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EL335_RS09320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EL335_RS09325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EL335_RS09335	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EL335_RS09365	COG2010	Cytochrome c
EL335_RS09390	COG0641	radical SAM
EL335_RS09410	COG2010	Cytochrome c
EL335_RS09415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EL335_RS09425	COG0584	glycerophosphoryl diester phosphodiesterase
EL335_RS09440	COG0513	Belongs to the DEAD box helicase family
EL335_RS09450	COG3876	Protein conserved in bacteria
EL335_RS09465	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EL335_RS09470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EL335_RS09475	COG0631	protein serine/threonine phosphatase activity
EL335_RS09485	COG0247	lactate metabolic process
EL335_RS09490	COG0277	FAD linked oxidase domain protein
EL335_RS09495	COG0277	FAD linked oxidase domain protein
EL335_RS09500	COG3622	Belongs to the hyi family
EL335_RS09550	COG3864	Putative metallopeptidase domain
EL335_RS09575	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
EL335_RS09585	COG2391	methyltransferase activity
EL335_RS09600	COG3260	NADH ubiquinone oxidoreductase 20
EL335_RS09605	COG3261	NADH dehydrogenase
EL335_RS09605	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
EL335_RS09610	COG0651	ATP synthesis coupled electron transport
EL335_RS09620	COG0650	Formate hydrogenlyase subunit 4
EL335_RS09625	COG0651	ATP synthesis coupled electron transport
EL335_RS09635	COG0471	metal ion transport
EL335_RS09635	COG3273	potassium ion transport
EL335_RS09650	COG0730	response to heat
EL335_RS09655	COG0745	RESPONSE REGULATOR receiver
EL335_RS09660	COG0642	Histidine kinase
EL335_RS09680	COG2096	Adenosyltransferase
EL335_RS09685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EL335_RS09695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EL335_RS09705	COG2203	Gaf domain
EL335_RS09705	COG4585	Histidine kinase
EL335_RS09715	COG3005	denitrification pathway
EL335_RS09720	COG0312	modulator of DNA gyrase
EL335_RS09735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EL335_RS09740	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EL335_RS09755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EL335_RS09765	COG2967	ApaG domain
EL335_RS09770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EL335_RS09775	COG0546	phosphoglycolate phosphatase activity
EL335_RS09795	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EL335_RS09850	COG1459	type II secretion system
EL335_RS09860	COG0446	pyridine nucleotide-disulphide oxidoreductase
EL335_RS09870	COG2205	protein histidine kinase activity
EL335_RS09880	COG2204	response regulator
EL335_RS09890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EL335_RS09895	COG0134	indole-3-glycerol-phosphate synthase activity
EL335_RS09900	COG0191	fructose-bisphosphate aldolase activity
EL335_RS09905	COG0469	pyruvate kinase activity
EL335_RS09910	COG0126	phosphoglycerate kinase activity
EL335_RS09915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EL335_RS09920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EL335_RS09925	COG3954	Phosphoribulokinase
EL335_RS09930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EL335_RS09945	COG1850	ribulose-bisphosphate carboxylase activity
EL335_RS09950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EL335_RS09970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EL335_RS09980	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EL335_RS09980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EL335_RS09985	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EL335_RS09990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EL335_RS10000	COG0508	dehydrogenase complex catalyzes the overall conversion of
EL335_RS10005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EL335_RS10015	COG0674	pyruvate-flavodoxin oxidoreductase activity
EL335_RS10020	COG1013	pyruvate-flavodoxin oxidoreductase activity
EL335_RS10025	COG0493	'glutamate synthase
EL335_RS10045	COG3240	lipase activity
EL335_RS10045	COG4625	pathogenesis
EL335_RS10070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EL335_RS10070	COG1796	DNA polymerase
EL335_RS10075	COG1067	ATP-dependent peptidase activity
EL335_RS10080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EL335_RS10085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EL335_RS10090	COG0508	dehydrogenase complex catalyzes the overall conversion of
EL335_RS10090	COG0022	dehydrogenase e1 component
EL335_RS10100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EL335_RS10120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EL335_RS10125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EL335_RS10130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EL335_RS10135	COG0009	L-threonylcarbamoyladenylate synthase
EL335_RS10155	COG4636	protein conserved in cyanobacteria
EL335_RS10160	COG0784	Response regulator, receiver
EL335_RS10180	COG4251	negative regulation of phosphorylation
EL335_RS10200	COG1335	isochorismatase
EL335_RS10215	COG1980	fructose-bisphosphate aldolase activity
EL335_RS10220	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EL335_RS10240	COG2046	Belongs to the sulfate adenylyltransferase family
EL335_RS10250	COG0315	cyclic pyranopterin monophosphate synthase activity
EL335_RS10280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EL335_RS10290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EL335_RS10295	COG0438	transferase activity, transferring glycosyl groups
EL335_RS10310	COG0367	asparagine synthase
EL335_RS10335	COG1216	Glycosyl transferase, family 2
EL335_RS10340	COG1216	Glycosyl transferase, family 2
EL335_RS10370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EL335_RS10375	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
EL335_RS10445	COG2814	Major facilitator Superfamily
EL335_RS10450	COG0629	single-stranded DNA binding
EL335_RS10455	COG2358	TRAP transporter, solute receptor (TAXI family
EL335_RS10460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EL335_RS10465	COG2823	Periplasmic or secreted lipoprotein
EL335_RS10470	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EL335_RS10475	COG0792	nuclease activity
EL335_RS10485	COG0418	dihydroorotase activity
EL335_RS10500	COG2001	Belongs to the MraZ family
EL335_RS10505	COG0275	rRNA processing
EL335_RS10510	COG3116	cell division
EL335_RS10525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EL335_RS10530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EL335_RS10535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EL335_RS10540	COG0772	Belongs to the SEDS family
EL335_RS10545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EL335_RS10550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EL335_RS10555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EL335_RS10560	COG1181	Belongs to the D-alanine--D-alanine ligase family
EL335_RS10565	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EL335_RS10580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EL335_RS10585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EL335_RS10590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EL335_RS10595	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EL335_RS10610	COG0006	proline dipeptidase activity
EL335_RS10615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EL335_RS10625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EL335_RS10630	COG0138	bifunctional purine biosynthesis protein purh
EL335_RS10635	COG0151	Belongs to the GarS family
EL335_RS10640	COG0408	coproporphyrinogen oxidase activity
EL335_RS10650	COG2959	enzyme of heme biosynthesis
EL335_RS10660	COG0181	hydroxymethylbilane synthase activity
EL335_RS10665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EL335_RS10670	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EL335_RS10680	COG3275	phosphorelay sensor kinase activity
EL335_RS10685	COG0165	Argininosuccinate lyase
EL335_RS10690	COG3001	Fructosamine kinase
EL335_RS10695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EL335_RS10705	COG1295	ribonuclease BN
EL335_RS10715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EL335_RS10725	COG0688	phosphatidylethanolamine metabolic process
EL335_RS10730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EL335_RS10735	COG0440	acetolactate synthase activity
EL335_RS10740	COG0028	Belongs to the TPP enzyme family
EL335_RS10765	COG0795	lipopolysaccharide-transporting ATPase activity
EL335_RS10770	COG0795	lipopolysaccharide-transporting ATPase activity
EL335_RS10775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EL335_RS10790	COG0525	valine-tRNA ligase activity
EL335_RS10795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EL335_RS10800	COG0671	phosphoesterase, PA-phosphatase related
EL335_RS10805	COG0463	Glycosyl transferase, family 2
EL335_RS10825	COG2210	Belongs to the sulfur carrier protein TusA family
EL335_RS10830	COG0425	Belongs to the sulfur carrier protein TusA family
EL335_RS10835	COG3302	dmso reductase anchor subunit
EL335_RS10840	COG0437	4 iron, 4 sulfur cluster binding
EL335_RS10850	COG0243	molybdopterin cofactor binding
EL335_RS10870	COG1233	COG1233 Phytoene dehydrogenase and related
EL335_RS10875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EL335_RS10880	COG2048	Heterodisulfide reductase, subunit B
EL335_RS10915	COG3744	PilT protein domain protein
EL335_RS10920	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EL335_RS10925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EL335_RS10940	COG2423	ornithine cyclodeaminase activity
EL335_RS10945	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EL335_RS10950	COG0045	succinate-CoA ligase (ADP-forming) activity
EL335_RS10985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EL335_RS10990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EL335_RS11000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EL335_RS11005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EL335_RS11015	COG0140	phosphoribosyl-ATP diphosphatase activity
EL335_RS11020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EL335_RS11025	COG0107	imidazoleglycerol-phosphate synthase activity
EL335_RS11030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EL335_RS11035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EL335_RS11040	COG0131	Imidazoleglycerol-phosphate dehydratase
EL335_RS11045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EL335_RS11050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EL335_RS11085	COG2853	Lipoprotein
EL335_RS11090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EL335_RS11095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EL335_RS11100	COG1127	ABC transporter
EL335_RS11110	COG3409	Peptidoglycan-binding domain 1 protein
EL335_RS11110	COG3267	Type II secretory pathway component ExeA
EL335_RS11125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EL335_RS11130	COG1459	type II secretion system
EL335_RS11160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EL335_RS11165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EL335_RS11170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EL335_RS11175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EL335_RS11205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EL335_RS11215	COG0316	Belongs to the HesB IscA family
EL335_RS11230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EL335_RS11235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EL335_RS11240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EL335_RS11245	COG1765	OsmC-like protein
EL335_RS11250	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EL335_RS11260	COG0494	nUDIX hydrolase
EL335_RS11265	COG0442	prolyl-tRNA aminoacylation
EL335_RS11270	COG0741	lytic transglycosylase activity
EL335_RS11275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EL335_RS11285	COG4536	flavin adenine dinucleotide binding
EL335_RS11310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EL335_RS11325	COG0494	nUDIX hydrolase
EL335_RS11330	COG0071	Belongs to the small heat shock protein (HSP20) family
EL335_RS11335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EL335_RS11345	COG1309	transcriptional regulator
EL335_RS11355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EL335_RS11370	COG2226	methyltransferase
EL335_RS11375	COG1040	competence protein
EL335_RS11385	COG3409	Peptidoglycan-binding domain 1 protein
EL335_RS11385	COG3267	Type II secretory pathway component ExeA
EL335_RS11415	COG4770	biotin carboxylase activity
EL335_RS11420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EL335_RS11425	COG1703	isobutyryl-CoA mutase activity
EL335_RS11440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EL335_RS11440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EL335_RS11450	COG0446	pyridine nucleotide-disulphide oxidoreductase
EL335_RS11455	COG1024	Enoyl-CoA hydratase
EL335_RS11465	COG1011	Hydrolase
EL335_RS11485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EL335_RS11490	COG0129	dihydroxy-acid dehydratase activity
EL335_RS11505	COG1331	Highly conserved protein containing a thioredoxin domain
EL335_RS11515	COG4566	intracellular signal transduction
EL335_RS11520	COG4191	Histidine kinase
EL335_RS11525	COG2855	membrane
EL335_RS11580	COG1981	membrane
EL335_RS11615	COG0762	integral membrane protein
EL335_RS11620	COG1872	DUF167
EL335_RS11625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EL335_RS11630	COG0012	GTP binding
EL335_RS11635	COG0193	aminoacyl-tRNA hydrolase activity
EL335_RS11640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EL335_RS11645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EL335_RS11655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EL335_RS11660	COG1940	carbohydrate kinase activity
EL335_RS11675	COG1127	ABC transporter
EL335_RS11685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EL335_RS11690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EL335_RS11695	COG0205	6-phosphofructokinase activity
EL335_RS11700	COG2119	membrane
EL335_RS11710	COG0569	domain protein
EL335_RS11715	COG2204	response regulator
EL335_RS11725	COG5000	phosphorelay sensor kinase activity
EL335_RS11745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EL335_RS11760	COG0758	DNA mediated transformation
EL335_RS11765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EL335_RS11765	COG0551	DNA topoisomerase type I activity
EL335_RS11775	COG1968	undecaprenyl-diphosphatase activity
EL335_RS11800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EL335_RS11805	COG0598	Magnesium transport protein CorA
EL335_RS11815	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EL335_RS11820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EL335_RS11830	COG0512	Glutamine amidotransferase of anthranilate synthase
EL335_RS11830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EL335_RS11835	COG1492	cobalamin metabolic process
EL335_RS11840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EL335_RS11860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EL335_RS11865	COG1797	cobyrinic acid a,c-diamide synthase activity
EL335_RS11880	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EL335_RS11885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EL335_RS11890	COG4206	TonB-dependent receptor
EL335_RS11925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EL335_RS11960	COG2022	thiamine diphosphate biosynthetic process
EL335_RS11970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EL335_RS11975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EL335_RS11980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EL335_RS11985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EL335_RS11990	COG0515	serine threonine protein kinase
EL335_RS11990	COG3266	domain, Protein
EL335_RS11995	COG1561	YicC-like family, N-terminal region
EL335_RS12000	COG0194	GDP metabolic process
EL335_RS12005	COG1758	RNA polymerase activity
EL335_RS12010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EL335_RS12030	COG0243	molybdopterin cofactor binding
EL335_RS12035	COG0437	4 iron, 4 sulfur cluster binding
EL335_RS12040	COG0348	domain, Protein
EL335_RS12065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EL335_RS12070	COG4235	cytochrome complex assembly
EL335_RS12075	COG3088	subunit of a heme lyase
EL335_RS12080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EL335_RS12090	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EL335_RS12110	COG4133	protoheme IX ABC transporter activity
EL335_RS12115	COG2878	Part of a membrane complex involved in electron transport
EL335_RS12120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EL335_RS12120	COG0674	pyruvate-flavodoxin oxidoreductase activity
EL335_RS12120	COG1013	pyruvate-flavodoxin oxidoreductase activity
EL335_RS12120	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EL335_RS12125	COG4656	Part of a membrane complex involved in electron transport
EL335_RS12130	COG4658	electron transport chain
EL335_RS12135	COG4659	FMN binding
EL335_RS12140	COG4660	Part of a membrane complex involved in electron transport
EL335_RS12145	COG4657	Part of a membrane complex involved in electron transport
EL335_RS12170	COG0730	response to heat
EL335_RS12175	COG0475	glutathione-regulated potassium exporter activity
EL335_RS12175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EL335_RS12185	COG0489	protein tyrosine kinase activity
EL335_RS12190	COG0280	phosphate acetyltransferase
EL335_RS12190	COG0281	malic enzyme
EL335_RS12195	COG2267	carboxylic ester hydrolase activity
EL335_RS12220	COG3706	GGDEF domain
EL335_RS12225	COG0495	leucyl-tRNA aminoacylation
EL335_RS12245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EL335_RS12250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EL335_RS12255	COG4974	Belongs to the 'phage' integrase family
EL335_RS12265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EL335_RS12270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EL335_RS12275	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EL335_RS12300	COG0791	NLP P60 protein
EL335_RS12315	COG0412	Dienelactone hydrolase
EL335_RS12320	COG1530	ribonuclease E activity
EL335_RS12325	COG0424	maF-like protein
EL335_RS12330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EL335_RS12335	COG0799	negative regulation of ribosome biogenesis
EL335_RS12340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EL335_RS12385	COG1136	(ABC) transporter
EL335_RS12385	COG0577	efflux transmembrane transporter activity
EL335_RS12390	COG1136	(ABC) transporter
EL335_RS12390	COG0577	efflux transmembrane transporter activity
EL335_RS12395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EL335_RS12400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EL335_RS12405	COG0352	thiamine-phosphate diphosphorylase activity
EL335_RS12410	COG0351	phosphomethylpyrimidine kinase
EL335_RS12415	COG0415	Belongs to the DNA photolyase family
EL335_RS12420	COG1678	Uncharacterized ACR, COG1678
EL335_RS12425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EL335_RS12435	COG0540	Belongs to the ATCase OTCase family
EL335_RS12440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EL335_RS12490	COG0606	chelatase, subunit chli
EL335_RS12505	COG0347	Belongs to the P(II) protein family
EL335_RS12510	COG0004	ammonium transporteR
EL335_RS12525	COG0840	transmembrane signaling receptor activity
EL335_RS12530	COG0488	(ABC) transporter
EL335_RS12555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EL335_RS12560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EL335_RS12565	COG0791	NLP P60 protein
EL335_RS12570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EL335_RS12575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EL335_RS12575	COG2813	Specifically methylates the guanine in position
EL335_RS12595	COG2945	thiolester hydrolase activity
EL335_RS12610	COG2814	Major facilitator Superfamily
EL335_RS12625	COG3154	lipid carrier protein
EL335_RS12630	COG0826	peptidase U32
EL335_RS12635	COG0826	peptidase U32
EL335_RS12640	COG0300	oxidoreductase activity
EL335_RS12645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EL335_RS12655	COG0018	arginyl-trna synthetase
EL335_RS12670	COG0450	alkyl hydroperoxide reductase
EL335_RS12680	COG0247	lactate metabolic process
EL335_RS12700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EL335_RS12705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EL335_RS12715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EL335_RS12720	COG1546	Belongs to the CinA family
EL335_RS12725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EL335_RS12730	COG2137	regulation of response to DNA damage stimulus
EL335_RS12735	COG1137	ATPase activity
EL335_RS12740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EL335_RS12745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EL335_RS12755	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EL335_RS12765	COG2226	methyltransferase
EL335_RS12775	COG2205	protein histidine kinase activity
EL335_RS12780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EL335_RS12785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EL335_RS12790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EL335_RS12795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EL335_RS12800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EL335_RS12805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EL335_RS12815	COG0356	it plays a direct role in the translocation of protons across the membrane
EL335_RS12825	COG1475	DNA binding
EL335_RS12830	COG1192	Involved in chromosome partitioning
EL335_RS12835	COG0357	Ribosomal RNA small subunit methyltransferase G
EL335_RS12840	COG0445	tRNA wobble uridine modification
EL335_RS12865	COG0730	response to heat
EL335_RS12870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EL335_RS12875	COG0706	membrane insertase activity
EL335_RS12880	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EL335_RS12885	COG0594	ribonuclease P activity
EL335_RS12890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EL335_RS12910	COG1475	DNA binding
EL335_RS12925	COG2826	transposase and inactivated derivatives, IS30 family
EL335_RS12990	COG0592	DNA-directed DNA polymerase activity
EL335_RS13060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EL335_RS13095	COG3328	transposase activity
EL335_RS13175	COG0776	regulation of translation
EL335_RS13210	COG1199	ATP-dependent helicase activity
EL335_RS13250	COG0322	excinuclease ABC activity
EL335_RS13260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EL335_RS13340	COG0463	Glycosyl transferase, family 2
EL335_RS13455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EL335_RS13535	COG4585	Histidine kinase
EL335_RS13580	COG0629	single-stranded DNA binding
EL335_RS13620	COG2894	cell division
EL335_RS13670	COG0739	heme binding
EL335_RS13700	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EL335_RS13740	COG4974	Belongs to the 'phage' integrase family
EL335_RS13755	COG1192	Involved in chromosome partitioning
EL335_RS13795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EL335_RS13810	COG1988	membrane-bound metal-dependent
EL335_RS14045	COG0210	DNA helicase
EL335_RS14065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EL335_RS14095	COG0629	single-stranded DNA binding
EL335_RS14165	COG2003	Belongs to the UPF0758 family
EL335_RS14195	COG0535	radical SAM domain protein
EL335_RS14205	COG1328	CTP reductase activity
EL335_RS14215	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EL335_RS14220	COG0840	transmembrane signaling receptor activity