locus-tag	class	description
M52SOB_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M52SOB_RS00010	COG0592	DNA-directed DNA polymerase activity
M52SOB_RS00025	COG2204	response regulator
M52SOB_RS00030	COG3852	Histidine kinase
M52SOB_RS00050	COG0243	molybdopterin cofactor binding
M52SOB_RS00085	COG0446	pyridine nucleotide-disulphide oxidoreductase
M52SOB_RS00095	COG3381	protein complex oligomerization
M52SOB_RS00105	COG0437	4 iron, 4 sulfur cluster binding
M52SOB_RS00110	COG0243	molybdopterin cofactor binding
M52SOB_RS00140	COG0243	molybdopterin cofactor binding
M52SOB_RS00150	COG4191	Histidine kinase
M52SOB_RS00180	COG0798	PFAM Bile acid sodium symporter
M52SOB_RS00190	COG1595	DNA-templated transcription, initiation
M52SOB_RS00200	COG1137	ATPase activity
M52SOB_RS00220	COG3220	belongs to the UPF0276 family
M52SOB_RS00235	COG1595	DNA-templated transcription, initiation
M52SOB_RS00265	COG2391	methyltransferase activity
M52SOB_RS00325	COG1230	cation diffusion facilitator family transporter
M52SOB_RS00365	COG1136	(ABC) transporter
M52SOB_RS00370	COG4591	ABC-type transport system involved in lipoprotein release permease component
M52SOB_RS00385	COG0183	Belongs to the thiolase family
M52SOB_RS00395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M52SOB_RS00425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M52SOB_RS00480	COG2814	Major facilitator Superfamily
M52SOB_RS00495	COG2885	chlorophyll binding
M52SOB_RS00510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M52SOB_RS00520	COG0037	tRNA processing
M52SOB_RS00535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M52SOB_RS00545	COG1858	cytochrome C peroxidase
M52SOB_RS00555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M52SOB_RS00560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M52SOB_RS00565	COG0308	aminopeptidase N
M52SOB_RS00585	COG3453	Protein conserved in bacteria
M52SOB_RS00585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M52SOB_RS00600	COG1294	oxidase, subunit
M52SOB_RS00640	COG4232	protein-disulfide reductase activity
M52SOB_RS00645	COG1324	tolerance protein
M52SOB_RS00650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M52SOB_RS00660	COG0516	GMP reductase activity
M52SOB_RS00660	COG0517	IMP dehydrogenase activity
M52SOB_RS00680	COG0022	dehydrogenase e1 component
M52SOB_RS00695	COG1131	(ABC) transporter
M52SOB_RS00700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M52SOB_RS00705	COG1970	mechanosensitive ion channel activity
M52SOB_RS00715	COG1702	phosphate starvation-inducible protein PhoH
M52SOB_RS00720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M52SOB_RS00725	COG4535	Mg2 and Co2 transporter CorC
M52SOB_RS00730	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M52SOB_RS00735	COG0752	glycyl-tRNA synthetase alpha subunit
M52SOB_RS00740	COG0751	glycine-tRNA ligase activity
M52SOB_RS00745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M52SOB_RS00805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M52SOB_RS00815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M52SOB_RS00825	COG0154	amidase activity
M52SOB_RS00830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M52SOB_RS00835	COG1077	Cell shape determining protein MreB Mrl
M52SOB_RS00845	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M52SOB_RS00850	COG0768	penicillin binding
M52SOB_RS00855	COG0772	Belongs to the SEDS family
M52SOB_RS00865	COG1686	Belongs to the peptidase S11 family
M52SOB_RS00870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M52SOB_RS00875	COG2921	Belongs to the UPF0250 family
M52SOB_RS00880	COG0321	lipoyl(octanoyl) transferase activity
M52SOB_RS00895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M52SOB_RS00910	COG0438	transferase activity, transferring glycosyl groups
M52SOB_RS00945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M52SOB_RS00950	COG0573	inorganic phosphate transmembrane transporter activity
M52SOB_RS00955	COG0573	inorganic phosphate transmembrane transporter activity
M52SOB_RS00960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M52SOB_RS00970	COG0210	DNA helicase
M52SOB_RS00975	COG0617	tRNA 3'-terminal CCA addition
M52SOB_RS00985	COG0741	lytic transglycosylase activity
M52SOB_RS00990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M52SOB_RS00995	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M52SOB_RS01005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M52SOB_RS01015	COG0840	transmembrane signaling receptor activity
M52SOB_RS01015	COG0840	transmembrane signaling receptor activity
M52SOB_RS01020	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
M52SOB_RS01030	COG0612	Peptidase, M16
M52SOB_RS01035	COG0612	Peptidase, M16
M52SOB_RS01060	COG0742	ribosomal rna small subunit methyltransferase
M52SOB_RS01065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M52SOB_RS01070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M52SOB_RS01075	COG0861	Integral membrane protein TerC family
M52SOB_RS01080	COG0589	response to stress
M52SOB_RS01095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M52SOB_RS01100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M52SOB_RS01105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M52SOB_RS01110	COG2271	Major facilitator Superfamily
M52SOB_RS01115	COG1999	signal sequence binding
M52SOB_RS01120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M52SOB_RS01130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M52SOB_RS01135	COG0511	ligase activity, forming carbon-carbon bonds
M52SOB_RS01140	COG0439	Biotin carboxylase
M52SOB_RS01145	COG2264	protein methyltransferase activity
M52SOB_RS01155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M52SOB_RS01170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M52SOB_RS01175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M52SOB_RS01180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M52SOB_RS01185	COG3568	Endonuclease Exonuclease Phosphatase
M52SOB_RS01195	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M52SOB_RS01200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M52SOB_RS01205	COG0174	glutamine synthetase
M52SOB_RS01215	COG3852	Histidine kinase
M52SOB_RS01230	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M52SOB_RS01230	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M52SOB_RS01235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M52SOB_RS01240	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
M52SOB_RS01245	COG0237	dephospho-CoA kinase activity
M52SOB_RS01250	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M52SOB_RS01255	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M52SOB_RS01260	COG0352	thiamine-phosphate diphosphorylase activity
M52SOB_RS01280	COG0004	ammonium transporteR
M52SOB_RS01290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M52SOB_RS01330	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M52SOB_RS01340	COG4942	peptidase
M52SOB_RS01370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M52SOB_RS01375	COG1238	metal cluster binding
M52SOB_RS01390	COG1902	pentaerythritol trinitrate reductase activity
M52SOB_RS01400	COG0432	Pfam Uncharacterised protein family UPF0047
M52SOB_RS01410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M52SOB_RS01440	COG0583	DNA-binding transcription factor activity
M52SOB_RS01445	COG0783	Belongs to the Dps family
M52SOB_RS01460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M52SOB_RS01470	COG3243	poly(R)-hydroxyalkanoic acid synthase
M52SOB_RS01475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M52SOB_RS01490	COG1960	acyl-CoA dehydrogenase activity
M52SOB_RS01495	COG0183	Belongs to the thiolase family
M52SOB_RS01500	COG0697	spore germination
M52SOB_RS01505	COG1960	acyl-CoA dehydrogenase activity
M52SOB_RS01510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M52SOB_RS01520	COG4770	biotin carboxylase activity
M52SOB_RS01530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M52SOB_RS01535	COG3161	chorismate lyase activity
M52SOB_RS01540	COG1660	Displays ATPase and GTPase activities
M52SOB_RS01590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M52SOB_RS01605	COG4636	protein conserved in cyanobacteria
M52SOB_RS01630	COG0438	transferase activity, transferring glycosyl groups
M52SOB_RS01645	COG0438	transferase activity, transferring glycosyl groups
M52SOB_RS01655	COG0726	polysaccharide deacetylase
M52SOB_RS01660	COG0438	transferase activity, transferring glycosyl groups
M52SOB_RS01665	COG1132	(ABC) transporter
M52SOB_RS01670	COG0438	transferase activity, transferring glycosyl groups
M52SOB_RS01675	COG0859	PFAM glycosyl transferase family 9
M52SOB_RS01690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M52SOB_RS01695	COG3338	carbonate dehydratase activity
M52SOB_RS01700	COG1194	a g-specific adenine glycosylase
M52SOB_RS01710	COG0142	geranyltranstransferase activity
M52SOB_RS01735	COG3023	N-Acetylmuramoyl-L-alanine amidase
M52SOB_RS01745	COG0436	Aminotransferase
M52SOB_RS01750	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M52SOB_RS01755	COG0281	malic enzyme
M52SOB_RS01755	COG0280	phosphate acetyltransferase
M52SOB_RS01760	COG1686	Belongs to the peptidase S11 family
M52SOB_RS01765	COG0247	lactate metabolic process
M52SOB_RS01770	COG1139	Iron-sulfur cluster binding protein
M52SOB_RS01805	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M52SOB_RS01830	COG0475	glutathione-regulated potassium exporter activity
M52SOB_RS01840	COG2271	Major facilitator Superfamily
M52SOB_RS01890	COG0436	Aminotransferase
M52SOB_RS01895	COG0488	(ABC) transporter
M52SOB_RS01925	COG0284	orotidine-5'-phosphate decarboxylase activity
M52SOB_RS01930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M52SOB_RS01935	COG1643	Atp-dependent helicase
M52SOB_RS01945	COG1058	Belongs to the CinA family
M52SOB_RS01945	COG1546	Belongs to the CinA family
M52SOB_RS01950	COG0577	efflux transmembrane transporter activity
M52SOB_RS01950	COG1136	(ABC) transporter
M52SOB_RS01955	COG1136	(ABC) transporter
M52SOB_RS01955	COG0577	efflux transmembrane transporter activity
M52SOB_RS01980	COG2165	general secretion pathway protein
M52SOB_RS01990	COG1459	type II secretion system
M52SOB_RS01995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M52SOB_RS02000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M52SOB_RS02005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M52SOB_RS02015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M52SOB_RS02020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M52SOB_RS02025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M52SOB_RS02035	COG0588	phosphoglycerate mutase activity
M52SOB_RS02040	COG4942	peptidase
M52SOB_RS02045	COG0793	Belongs to the peptidase S41A family
M52SOB_RS02055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M52SOB_RS02060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M52SOB_RS02060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M52SOB_RS02065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M52SOB_RS02070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M52SOB_RS02085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M52SOB_RS02100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M52SOB_RS02105	COG0312	modulator of DNA gyrase
M52SOB_RS02110	COG3028	Belongs to the UPF0307 family
M52SOB_RS02115	COG0521	Mo-molybdopterin cofactor biosynthetic process
M52SOB_RS02120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M52SOB_RS02125	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M52SOB_RS02150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M52SOB_RS02160	COG0166	Belongs to the GPI family
M52SOB_RS02165	COG0297	glycogen (starch) synthase activity
M52SOB_RS02180	COG0717	Belongs to the dCTP deaminase family
M52SOB_RS02185	COG0489	protein tyrosine kinase activity
M52SOB_RS02190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M52SOB_RS02190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M52SOB_RS02195	COG1254	Belongs to the acylphosphatase family
M52SOB_RS02210	COG0737	Belongs to the 5'-nucleotidase family
M52SOB_RS02215	COG2010	Cytochrome c
M52SOB_RS02260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M52SOB_RS02280	COG0823	Involved in the tonB-independent uptake of proteins
M52SOB_RS02300	COG0824	Thioesterase
M52SOB_RS02305	COG2255	four-way junction helicase activity
M52SOB_RS02310	COG0628	permease
M52SOB_RS02315	COG0632	four-way junction helicase activity
M52SOB_RS02320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M52SOB_RS02325	COG0217	transcriptional regulatory protein
M52SOB_RS02335	COG0433	COG0433 Predicted ATPase
M52SOB_RS02350	COG5001	Diguanylate cyclase
M52SOB_RS02350	COG3300	MHYT domain
M52SOB_RS02360	COG4771	TonB-dependent receptor
M52SOB_RS02385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M52SOB_RS02390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M52SOB_RS02400	COG1560	Kdo2-lipid A biosynthetic process
M52SOB_RS02405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M52SOB_RS02415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M52SOB_RS02435	COG1136	(ABC) transporter
M52SOB_RS02435	COG0577	efflux transmembrane transporter activity
M52SOB_RS02465	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M52SOB_RS02470	COG1121	(ABC) transporter
M52SOB_RS02475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M52SOB_RS02480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M52SOB_RS02485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M52SOB_RS02490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M52SOB_RS02505	COG1965	Belongs to the frataxin family
M52SOB_RS02540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M52SOB_RS02545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M52SOB_RS02550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M52SOB_RS02555	COG0069	glutamate synthase activity
M52SOB_RS02555	COG0067	glutamate synthase
M52SOB_RS02555	COG0070	glutamate synthase
M52SOB_RS02565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M52SOB_RS02575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M52SOB_RS02600	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M52SOB_RS02605	COG1703	isobutyryl-CoA mutase activity
M52SOB_RS02605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M52SOB_RS02605	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M52SOB_RS02610	COG4178	(ABC) transporter
M52SOB_RS02615	COG0473	3-isopropylmalate dehydrogenase activity
M52SOB_RS02620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M52SOB_RS02625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M52SOB_RS02630	COG0066	3-isopropylmalate dehydratase activity
M52SOB_RS02635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M52SOB_RS02645	COG0826	peptidase U32
M52SOB_RS02665	COG1022	Amp-dependent synthetase and ligase
M52SOB_RS02695	COG0318	PFAM AMP-dependent synthetase and ligase
M52SOB_RS02705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M52SOB_RS02720	COG2197	response regulator
M52SOB_RS02740	COG0277	FAD linked oxidase domain protein
M52SOB_RS02770	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M52SOB_RS02780	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M52SOB_RS02785	COG0081	regulation of translation
M52SOB_RS02790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M52SOB_RS02795	COG0222	ribosome binding
M52SOB_RS02800	COG0085	RNA polymerase activity
M52SOB_RS02805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M52SOB_RS02810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M52SOB_RS02815	COG0049	tRNA binding
M52SOB_RS02820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M52SOB_RS02830	COG0051	transcription antitermination factor activity, RNA binding
M52SOB_RS02835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M52SOB_RS02840	COG0088	Forms part of the polypeptide exit tunnel
M52SOB_RS02845	COG0089	rRNA binding
M52SOB_RS02850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M52SOB_RS02855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M52SOB_RS02860	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M52SOB_RS02865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M52SOB_RS02870	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M52SOB_RS02875	COG0255	Belongs to the universal ribosomal protein uL29 family
M52SOB_RS02880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M52SOB_RS02885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M52SOB_RS02890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M52SOB_RS02895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M52SOB_RS02900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M52SOB_RS02905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M52SOB_RS02910	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M52SOB_RS02915	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M52SOB_RS02920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M52SOB_RS02925	COG1841	ribosomal large subunit assembly
M52SOB_RS02930	COG0200	Binds to the 23S rRNA
M52SOB_RS02935	COG0201	protein transport
M52SOB_RS02945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M52SOB_RS02950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M52SOB_RS02955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M52SOB_RS02960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M52SOB_RS02965	COG0202	RNA polymerase activity
M52SOB_RS02970	COG0203	ribosomal protein L17
M52SOB_RS02975	COG2840	Smr protein MutS2
M52SOB_RS02980	COG0492	ferredoxin-NADP+ reductase activity
M52SOB_RS02985	COG1674	ftsk spoiiie
M52SOB_RS02990	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M52SOB_RS02995	COG1280	lysine exporter protein (LysE YggA)
M52SOB_RS03000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M52SOB_RS03005	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M52SOB_RS03010	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M52SOB_RS03020	COG2920	part of a sulfur-relay system
M52SOB_RS03060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M52SOB_RS03075	COG0784	Response regulator, receiver
M52SOB_RS03075	COG0835	chemotaxis
M52SOB_RS03080	COG0784	Response regulator, receiver
M52SOB_RS03080	COG0835	chemotaxis
M52SOB_RS03090	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M52SOB_RS03095	COG0643	Histidine kinase
M52SOB_RS03095	COG2198	Histidine kinase
M52SOB_RS03095	COG0784	Response regulator, receiver
M52SOB_RS03105	COG4969	Belongs to the N-Me-Phe pilin family
M52SOB_RS03125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M52SOB_RS03130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M52SOB_RS03150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M52SOB_RS03155	COG1360	Flagellar Motor Protein
M52SOB_RS03175	COG1815	bacterial-type flagellum-dependent cell motility
M52SOB_RS03180	COG1558	bacterial-type flagellum-dependent cell motility
M52SOB_RS03185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M52SOB_RS03190	COG1749	Flagellar hook protein flgE
M52SOB_RS03205	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M52SOB_RS03210	COG1706	bacterial-type flagellum-dependent cell motility
M52SOB_RS03220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M52SOB_RS03250	COG1256	bacterial-type flagellum assembly
M52SOB_RS03260	COG1086	Polysaccharide biosynthesis protein
M52SOB_RS03265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M52SOB_RS03270	COG1083	cytidylyl-transferase
M52SOB_RS03285	COG2089	acid synthase
M52SOB_RS03300	COG1987	bacterial-type flagellum assembly
M52SOB_RS03320	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M52SOB_RS03340	COG1157	protein secretion by the type III secretion system
M52SOB_RS03370	COG1677	Flagellar hook-basal body complex protein FliE
M52SOB_RS03380	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M52SOB_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
M52SOB_RS03405	COG1960	acyl-CoA dehydrogenase activity
M52SOB_RS03410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M52SOB_RS03415	COG2358	TRAP transporter, solute receptor (TAXI family
M52SOB_RS03435	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M52SOB_RS03440	COG0501	Belongs to the peptidase M48B family
M52SOB_RS03445	COG0583	DNA-binding transcription factor activity
M52SOB_RS03465	COG0277	FAD linked oxidase domain protein
M52SOB_RS03470	COG1752	Esterase of the alpha-beta hydrolase superfamily
M52SOB_RS03475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M52SOB_RS03485	COG3243	poly(R)-hydroxyalkanoic acid synthase
M52SOB_RS03505	COG0564	pseudouridine synthase activity
M52SOB_RS03515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M52SOB_RS03530	COG0557	exoribonuclease II activity
M52SOB_RS03550	COG0859	PFAM glycosyl transferase family 9
M52SOB_RS03570	COG0482	sulfurtransferase activity
M52SOB_RS03575	COG0625	glutathione transferase activity
M52SOB_RS03600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M52SOB_RS03605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M52SOB_RS03610	COG1862	Preprotein translocase
M52SOB_RS03615	COG0343	queuine tRNA-ribosyltransferase activity
M52SOB_RS03620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M52SOB_RS03645	COG3259	Nickel-dependent hydrogenase
M52SOB_RS03650	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
M52SOB_RS03655	COG3383	formate dehydrogenase (NAD+) activity
M52SOB_RS03660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M52SOB_RS03670	COG0298	carbon dioxide binding
M52SOB_RS03675	COG0409	Hydrogenase expression formation protein
M52SOB_RS03680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M52SOB_RS03680	COG1024	Enoyl-CoA hydratase
M52SOB_RS03685	COG2204	response regulator
M52SOB_RS03695	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
M52SOB_RS03705	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
M52SOB_RS03710	COG0437	4 iron, 4 sulfur cluster binding
M52SOB_RS03715	COG5557	Pfam Polysulphide reductase, NrfD
M52SOB_RS03720	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
M52SOB_RS03725	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M52SOB_RS03735	COG0375	protein maturation
M52SOB_RS03745	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
M52SOB_RS03760	COG0501	Belongs to the peptidase M48B family
M52SOB_RS03765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M52SOB_RS03770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M52SOB_RS03775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M52SOB_RS03780	COG0339	signal peptide processing
M52SOB_RS03790	COG0708	Exodeoxyribonuclease III
M52SOB_RS03795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M52SOB_RS03805	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M52SOB_RS03820	COG0739	heme binding
M52SOB_RS03825	COG0653	protein targeting
M52SOB_RS03830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M52SOB_RS03835	COG0235	Class ii aldolase
M52SOB_RS03840	COG0243	molybdopterin cofactor binding
M52SOB_RS03845	COG2146	nitrite reductase [NAD(P)H] activity
M52SOB_RS03850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M52SOB_RS03855	COG1116	anion transmembrane transporter activity
M52SOB_RS03860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M52SOB_RS03865	COG1116	anion transmembrane transporter activity
M52SOB_RS03865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M52SOB_RS03870	COG3707	response regulator
M52SOB_RS03875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M52SOB_RS03880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M52SOB_RS03885	COG0505	Belongs to the CarA family
M52SOB_RS03895	COG0735	belongs to the Fur family
M52SOB_RS03960	COG1136	(ABC) transporter
M52SOB_RS04035	COG1845	cytochrome c oxidase, subunit III
M52SOB_RS04055	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M52SOB_RS04080	COG5002	protein histidine kinase activity
M52SOB_RS04080	COG5001	Diguanylate cyclase
M52SOB_RS04095	COG1575	Belongs to the MenA family. Type 1 subfamily
M52SOB_RS04100	COG2226	methyltransferase
M52SOB_RS04105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M52SOB_RS04120	COG1131	(ABC) transporter
M52SOB_RS04135	COG0348	domain, Protein
M52SOB_RS04140	COG0437	4 iron, 4 sulfur cluster binding
M52SOB_RS04160	COG2863	cytochrome
M52SOB_RS04165	COG4263	nitrous-oxide reductase activity
M52SOB_RS04170	COG2197	response regulator
M52SOB_RS04180	COG4263	nitrous-oxide reductase activity
M52SOB_RS04195	COG1162	GTPase activity
M52SOB_RS04200	COG2154	pterin-4-alpha-carbinolamine dehydratase
M52SOB_RS04205	COG0501	Belongs to the peptidase M48B family
M52SOB_RS04210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M52SOB_RS04220	COG0254	rRNA binding
M52SOB_RS04225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M52SOB_RS04235	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M52SOB_RS04240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M52SOB_RS04255	COG0617	tRNA 3'-terminal CCA addition
M52SOB_RS04265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M52SOB_RS04270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M52SOB_RS04275	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M52SOB_RS04290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M52SOB_RS04295	COG0586	Pfam SNARE associated Golgi protein
M52SOB_RS04305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M52SOB_RS04315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M52SOB_RS04315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M52SOB_RS04320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M52SOB_RS04325	COG3264	Mechanosensitive ion channel
M52SOB_RS04325	COG1511	domain protein
M52SOB_RS04340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M52SOB_RS04345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M52SOB_RS04350	COG2003	Belongs to the UPF0758 family
M52SOB_RS04355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M52SOB_RS04360	COG0756	dUTP diphosphatase activity
M52SOB_RS04365	COG0446	pyridine nucleotide-disulphide oxidoreductase
M52SOB_RS04370	COG2863	cytochrome
M52SOB_RS04380	COG3005	denitrification pathway
M52SOB_RS04385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M52SOB_RS04400	COG2224	Isocitrate lyase
M52SOB_RS04405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M52SOB_RS04410	COG0542	response to heat
M52SOB_RS04415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M52SOB_RS04420	COG1278	Cold shock
M52SOB_RS04425	COG0538	isocitrate dehydrogenase activity
M52SOB_RS04430	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M52SOB_RS04450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M52SOB_RS04455	COG1278	Cold shock
M52SOB_RS04460	COG0437	4 iron, 4 sulfur cluster binding
M52SOB_RS04485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M52SOB_RS04490	COG1570	exodeoxyribonuclease VII activity
M52SOB_RS04515	COG2920	part of a sulfur-relay system
M52SOB_RS04520	COG1122	ATPase activity
M52SOB_RS04530	COG0310	cobalt ion transport
M52SOB_RS04570	COG0456	acetyltransferase
M52SOB_RS04575	COG1573	uracil-dna glycosylase
M52SOB_RS04580	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M52SOB_RS04585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M52SOB_RS04590	COG1388	LysM domain
M52SOB_RS04590	COG4942	peptidase
M52SOB_RS04600	COG2815	serine threonine protein kinase
M52SOB_RS04600	COG0515	serine threonine protein kinase
M52SOB_RS04605	COG2951	lytic endotransglycosylase activity
M52SOB_RS04620	COG0714	Associated with various cellular activities
M52SOB_RS04625	COG0123	including yeast histone deacetylase and acetoin utilization protein
M52SOB_RS04630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M52SOB_RS04635	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M52SOB_RS04640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M52SOB_RS04640	COG0321	lipoyl(octanoyl) transferase activity
M52SOB_RS04650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M52SOB_RS04660	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M52SOB_RS04670	COG2361	Protein of unknown function DUF86
M52SOB_RS04680	COG1217	gtp-binding protein TYPA
M52SOB_RS04690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M52SOB_RS04695	COG0024	Methionine aminopeptidase
M52SOB_RS04700	COG0052	Belongs to the universal ribosomal protein uS2 family
M52SOB_RS04705	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M52SOB_RS04710	COG0528	UMP kinase activity
M52SOB_RS04715	COG0233	cytoplasmic translational termination
M52SOB_RS04720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M52SOB_RS04725	COG0575	Belongs to the CDS family
M52SOB_RS04730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M52SOB_RS04750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M52SOB_RS04755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M52SOB_RS04760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M52SOB_RS04765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M52SOB_RS04775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M52SOB_RS04790	COG2205	protein histidine kinase activity
M52SOB_RS04790	COG2198	Histidine kinase
M52SOB_RS04790	COG0784	Response regulator, receiver
M52SOB_RS04810	COG0330	HflC and HflK could
M52SOB_RS04815	COG2814	Major facilitator Superfamily
M52SOB_RS04820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M52SOB_RS04825	COG2867	negative regulation of translational initiation
M52SOB_RS04830	COG2914	Belongs to the UPF0125 (RnfH) family
M52SOB_RS04845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M52SOB_RS04845	COG0519	Catalyzes the synthesis of GMP from XMP
M52SOB_RS04850	COG2814	Major facilitator Superfamily
M52SOB_RS04855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M52SOB_RS04860	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
M52SOB_RS04865	COG0058	SHG alpha-glucan phosphorylase activity
M52SOB_RS04885	COG1993	acr, cog1993
M52SOB_RS04895	COG0303	'Molybdopterin
M52SOB_RS04905	COG1028	Short-chain dehydrogenase reductase Sdr
M52SOB_RS04920	COG2414	aldehyde ferredoxin oxidoreductase
M52SOB_RS04925	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M52SOB_RS04940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M52SOB_RS04950	COG2183	response to ionizing radiation
M52SOB_RS04965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M52SOB_RS04975	COG1923	regulation of RNA biosynthetic process
M52SOB_RS04980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M52SOB_RS04985	COG0330	HflC and HflK could
M52SOB_RS04990	COG0330	HflC and HflK could
M52SOB_RS05000	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M52SOB_RS05005	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M52SOB_RS05020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M52SOB_RS05050	COG0778	Nitroreductase
M52SOB_RS05080	COG2176	DNA-directed DNA polymerase activity
M52SOB_RS05080	COG5002	protein histidine kinase activity
M52SOB_RS05095	COG0601	transmembrane transport
M52SOB_RS05100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M52SOB_RS05110	COG1388	LysM domain
M52SOB_RS05110	COG0741	lytic transglycosylase activity
M52SOB_RS05130	COG0105	UTP biosynthetic process
M52SOB_RS05135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M52SOB_RS05145	COG1426	Protein conserved in bacteria
M52SOB_RS05150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M52SOB_RS05155	COG0124	histidyl-tRNA synthetase
M52SOB_RS05160	COG2976	Protein conserved in bacteria
M52SOB_RS05170	COG1160	GTP binding
M52SOB_RS05175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M52SOB_RS05180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M52SOB_RS05190	COG2814	Major facilitator Superfamily
M52SOB_RS05205	COG0473	3-isopropylmalate dehydrogenase activity
M52SOB_RS05225	COG0101	tRNA pseudouridine synthase activity
M52SOB_RS05230	COG0135	phosphoribosylanthranilate isomerase activity
M52SOB_RS05235	COG0133	tryptophan synthase activity
M52SOB_RS05250	COG0159	tryptophan synthase activity
M52SOB_RS05255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M52SOB_RS05260	COG0285	dihydrofolate synthase activity
M52SOB_RS05290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M52SOB_RS05295	COG0723	plastoquinol--plastocyanin reductase activity
M52SOB_RS05300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M52SOB_RS05305	COG2857	Cytochrome c1
M52SOB_RS05310	COG0625	glutathione transferase activity
M52SOB_RS05315	COG2969	positive regulation of protein catabolic process
M52SOB_RS05330	COG0360	Binds together with S18 to 16S ribosomal RNA
M52SOB_RS05340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M52SOB_RS05345	COG0359	binds to the 23S rRNA
M52SOB_RS05350	COG0305	Participates in initiation and elongation during chromosome replication
M52SOB_RS05355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M52SOB_RS05360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M52SOB_RS05365	COG0726	polysaccharide deacetylase
M52SOB_RS05375	COG0436	Aminotransferase
M52SOB_RS05405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M52SOB_RS05415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M52SOB_RS05415	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M52SOB_RS05420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M52SOB_RS05430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M52SOB_RS05435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M52SOB_RS05440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M52SOB_RS05455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M52SOB_RS05460	COG0271	Belongs to the BolA IbaG family
M52SOB_RS05465	COG2350	Protein conserved in bacteria
M52SOB_RS05470	COG2917	probably involved in intracellular septation
M52SOB_RS05475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M52SOB_RS05480	COG0513	Belongs to the DEAD box helicase family
M52SOB_RS05490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M52SOB_RS05495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M52SOB_RS05505	COG0215	cysteine-tRNA ligase activity
M52SOB_RS05510	COG0825	malonyl-CoA metabolic process
M52SOB_RS05515	COG0037	tRNA processing
M52SOB_RS05520	COG4566	intracellular signal transduction
M52SOB_RS05535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M52SOB_RS05540	COG0488	(ABC) transporter
M52SOB_RS05565	COG0326	Molecular chaperone. Has ATPase activity
M52SOB_RS05575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M52SOB_RS05585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M52SOB_RS05595	COG4660	Part of a membrane complex involved in electron transport
M52SOB_RS05600	COG4659	FMN binding
M52SOB_RS05605	COG4658	electron transport chain
M52SOB_RS05615	COG2878	Part of a membrane complex involved in electron transport
M52SOB_RS05625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M52SOB_RS05630	COG0248	Ppx GppA phosphatase
M52SOB_RS05635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M52SOB_RS05640	COG1127	ABC transporter
M52SOB_RS05655	COG1534	Rna-binding protein
M52SOB_RS05660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M52SOB_RS05665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M52SOB_RS05680	COG3842	ATPase activity
M52SOB_RS05685	COG4208	sulfate ABC transporter
M52SOB_RS05690	COG0725	ABC transporter, periplasmic molybdate-binding protein
M52SOB_RS05700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M52SOB_RS05715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M52SOB_RS05725	COG0306	phosphate transporter
M52SOB_RS05750	COG1309	transcriptional regulator
M52SOB_RS05755	COG1960	acyl-CoA dehydrogenase activity
M52SOB_RS05765	COG1250	3-hydroxyacyl-CoA dehydrogenase
M52SOB_RS05765	COG1024	Enoyl-CoA hydratase
M52SOB_RS05770	COG0183	Belongs to the thiolase family
M52SOB_RS05785	COG0318	PFAM AMP-dependent synthetase and ligase
M52SOB_RS05795	COG1960	acyl-CoA dehydrogenase activity
M52SOB_RS05805	COG0309	Hydrogenase expression formation protein (HypE)
M52SOB_RS05825	COG0039	L-malate dehydrogenase activity
M52SOB_RS05835	COG2009	succinate dehydrogenase
M52SOB_RS05845	COG1053	succinate dehydrogenase
M52SOB_RS05850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M52SOB_RS05855	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M52SOB_RS05860	COG0372	Belongs to the citrate synthase family
M52SOB_RS05865	COG0567	Dehydrogenase, E1 component
M52SOB_RS05870	COG0508	dehydrogenase complex catalyzes the overall conversion of
M52SOB_RS05875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M52SOB_RS05885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M52SOB_RS05895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M52SOB_RS05900	COG2937	Belongs to the GPAT DAPAT family
M52SOB_RS05910	COG0167	dihydroorotate dehydrogenase activity
M52SOB_RS05915	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M52SOB_RS05920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M52SOB_RS05925	COG3842	ATPase activity
M52SOB_RS05960	COG1840	ABC-type Fe3 transport system, periplasmic component
M52SOB_RS05965	COG0604	alcohol dehydrogenase
M52SOB_RS05970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M52SOB_RS05980	COG0149	triose-phosphate isomerase activity
M52SOB_RS05995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M52SOB_RS06000	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M52SOB_RS06010	COG0649	NAD binding
M52SOB_RS06015	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M52SOB_RS06025	COG1034	ATP synthesis coupled electron transport
M52SOB_RS06030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M52SOB_RS06035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M52SOB_RS06045	COG0713	ATP synthesis coupled electron transport
M52SOB_RS06060	COG1007	ATP synthesis coupled electron transport
M52SOB_RS06095	COG1199	ATP-dependent helicase activity
M52SOB_RS06110	COG1763	Mo-molybdopterin cofactor biosynthetic process
M52SOB_RS06115	COG0303	'Molybdopterin
M52SOB_RS06120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M52SOB_RS06125	COG0314	molybdopterin synthase activity
M52SOB_RS06150	COG5001	Diguanylate cyclase
M52SOB_RS06155	COG2205	protein histidine kinase activity
M52SOB_RS06155	COG0784	Response regulator, receiver
M52SOB_RS06170	COG0542	response to heat
M52SOB_RS06190	COG2818	Glycosylase
M52SOB_RS06195	COG3108	Peptidase M15
M52SOB_RS06200	COG2989	Protein conserved in bacteria
M52SOB_RS06205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M52SOB_RS06205	COG1042	CoA-binding domain protein
M52SOB_RS06205	COG0045	succinate-CoA ligase (ADP-forming) activity
M52SOB_RS06220	COG1187	pseudouridine synthase activity
M52SOB_RS06230	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
M52SOB_RS06245	COG4181	ATPase activity
M52SOB_RS06260	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
M52SOB_RS06270	COG1562	ergosterol biosynthetic process
M52SOB_RS06280	COG0544	peptidyl-prolyl cis-trans isomerase activity
M52SOB_RS06285	COG0740	serine-type endopeptidase activity
M52SOB_RS06290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M52SOB_RS06295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M52SOB_RS06305	COG3118	belongs to the thioredoxin family
M52SOB_RS06310	COG2084	Dehydrogenase
M52SOB_RS06315	COG1881	PFAM PEBP family protein
M52SOB_RS06320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M52SOB_RS06320	COG0047	phosphoribosylformylglycinamidine synthase activity
M52SOB_RS06325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M52SOB_RS06330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M52SOB_RS06335	COG0746	molybdenum cofactor guanylyltransferase activity
M52SOB_RS06340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M52SOB_RS06360	COG0840	transmembrane signaling receptor activity
M52SOB_RS06375	COG0515	serine threonine protein kinase
M52SOB_RS06375	COG2815	serine threonine protein kinase
M52SOB_RS06395	COG0084	hydrolase, TatD family'
M52SOB_RS06405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M52SOB_RS06410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M52SOB_RS06415	COG0354	folic acid binding
M52SOB_RS06440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M52SOB_RS06440	COG0574	Belongs to the PEP-utilizing enzyme family
M52SOB_RS06445	COG2974	May be involved in recombination
M52SOB_RS06450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M52SOB_RS06450	COG0189	ligase activity
M52SOB_RS06455	COG0189	ligase activity
M52SOB_RS06455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M52SOB_RS06460	COG1132	(ABC) transporter
M52SOB_RS06475	COG5001	Diguanylate cyclase
M52SOB_RS06475	COG3300	MHYT domain
M52SOB_RS06480	COG4191	Histidine kinase
M52SOB_RS06485	COG3437	response regulator, receiver
M52SOB_RS06490	COG3852	Histidine kinase
M52SOB_RS06500	COG1640	4-alpha-glucanotransferase
M52SOB_RS06525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M52SOB_RS06530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M52SOB_RS06535	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M52SOB_RS06545	COG0776	regulation of translation
M52SOB_RS06555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M52SOB_RS06560	COG0287	Prephenate dehydrogenase
M52SOB_RS06565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M52SOB_RS06575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M52SOB_RS06580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M52SOB_RS06590	COG0402	S-adenosylhomocysteine deaminase activity
M52SOB_RS06600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M52SOB_RS06615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M52SOB_RS06625	COG0527	aspartate kinase activity
M52SOB_RS06660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M52SOB_RS06670	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M52SOB_RS06670	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M52SOB_RS06675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M52SOB_RS06695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M52SOB_RS06705	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M52SOB_RS06720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M52SOB_RS06725	COG0583	DNA-binding transcription factor activity
M52SOB_RS06730	COG0477	Major facilitator Superfamily
M52SOB_RS06740	COG0187	DNA topoisomerase II activity
M52SOB_RS06770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M52SOB_RS06775	COG1074	ATP-dependent DNA helicase activity
M52SOB_RS06780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M52SOB_RS06785	COG1490	D-aminoacyl-tRNA deacylase activity
M52SOB_RS06835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M52SOB_RS06840	COG1355	regulation of microtubule-based process
M52SOB_RS06860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M52SOB_RS06865	COG1393	Belongs to the ArsC family
M52SOB_RS06870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M52SOB_RS06875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M52SOB_RS06880	COG0509	glycine decarboxylation via glycine cleavage system
M52SOB_RS06885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M52SOB_RS06885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M52SOB_RS06900	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M52SOB_RS06905	COG0148	phosphopyruvate hydratase activity
M52SOB_RS06915	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M52SOB_RS06930	COG0504	CTP synthase activity
M52SOB_RS06940	COG0322	excinuclease ABC activity
M52SOB_RS06990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M52SOB_RS07000	COG1472	Belongs to the glycosyl hydrolase 3 family
M52SOB_RS07005	COG0736	holo-[acyl-carrier-protein] synthase activity
M52SOB_RS07010	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M52SOB_RS07015	COG1381	Involved in DNA repair and RecF pathway recombination
M52SOB_RS07020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M52SOB_RS07025	COG0571	ribonuclease III activity
M52SOB_RS07035	COG0681	Belongs to the peptidase S26 family
M52SOB_RS07040	COG0481	GTPase activity
M52SOB_RS07050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M52SOB_RS07060	COG3026	antisigma factor binding
M52SOB_RS07075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M52SOB_RS07085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M52SOB_RS07090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M52SOB_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
M52SOB_RS07105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M52SOB_RS07110	COG0416	fatty acid biosynthetic process
M52SOB_RS07115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M52SOB_RS07120	COG1399	metal-binding, possibly nucleic acid-binding protein
M52SOB_RS07125	COG0424	maF-like protein
M52SOB_RS07130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M52SOB_RS07135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M52SOB_RS07135	COG0616	signal peptide processing
M52SOB_RS07145	COG0546	phosphoglycolate phosphatase activity
M52SOB_RS07155	COG1530	ribonuclease E activity
M52SOB_RS07160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M52SOB_RS07165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M52SOB_RS07170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M52SOB_RS07200	COG1136	(ABC) transporter
M52SOB_RS07305	COG1185	polyribonucleotide nucleotidyltransferase activity
M52SOB_RS07310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M52SOB_RS07315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M52SOB_RS07320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M52SOB_RS07325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M52SOB_RS07330	COG0195	Participates in both transcription termination and antitermination
M52SOB_RS07335	COG0779	Required for maturation of 30S ribosomal subunits
M52SOB_RS07340	COG1187	pseudouridine synthase activity
M52SOB_RS07345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M52SOB_RS07355	COG2050	protein possibly involved in aromatic compounds catabolism
M52SOB_RS07360	COG0180	Tryptophanyl-tRNA synthetase
M52SOB_RS07365	COG1994	Peptidase M50
M52SOB_RS07370	COG0009	L-threonylcarbamoyladenylate synthase
M52SOB_RS07375	COG0613	PHP domain protein
M52SOB_RS07380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M52SOB_RS07385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M52SOB_RS07400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M52SOB_RS07405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M52SOB_RS07415	COG0156	8-amino-7-oxononanoate synthase activity
M52SOB_RS07420	COG2267	carboxylic ester hydrolase activity
M52SOB_RS07425	COG4106	trans-aconitate 2-methyltransferase activity
M52SOB_RS07425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M52SOB_RS07445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M52SOB_RS07460	COG2171	N-acyltransferase activity
M52SOB_RS07470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M52SOB_RS07485	COG1881	PFAM PEBP family protein
M52SOB_RS07490	COG1187	pseudouridine synthase activity
M52SOB_RS07495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M52SOB_RS07500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M52SOB_RS07535	COG0556	nucleotide-excision repair
M52SOB_RS07605	COG0577	efflux transmembrane transporter activity
M52SOB_RS07610	COG1136	(ABC) transporter
M52SOB_RS07610	COG0577	efflux transmembrane transporter activity
M52SOB_RS07620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M52SOB_RS07625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M52SOB_RS07630	COG0328	RNA-DNA hybrid ribonuclease activity
M52SOB_RS07635	COG2226	methyltransferase
M52SOB_RS07640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M52SOB_RS07645	COG0497	DNA recombination
M52SOB_RS07650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M52SOB_RS07660	COG1420	regulation of RNA biosynthetic process
M52SOB_RS07665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M52SOB_RS07680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M52SOB_RS07685	COG0443	Heat shock 70 kDa protein
M52SOB_RS07690	COG0484	heat shock protein binding
M52SOB_RS07695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M52SOB_RS07720	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M52SOB_RS07725	COG0084	hydrolase, TatD family'
M52SOB_RS07740	COG0443	Heat shock 70 kDa protein
M52SOB_RS07745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M52SOB_RS07755	COG0822	iron-sulfur transferase activity
M52SOB_RS07760	COG1104	cysteine desulfurase activity
M52SOB_RS07775	COG1045	serine acetyltransferase
M52SOB_RS07785	COG0483	inositol monophosphate 1-phosphatase activity
M52SOB_RS07845	COG1484	DNA-dependent DNA replication
M52SOB_RS07850	COG4584	PFAM Integrase catalytic
M52SOB_RS07860	COG3391	amine dehydrogenase activity
M52SOB_RS07870	COG1858	cytochrome C peroxidase
M52SOB_RS07875	COG3284	Transcriptional regulator
M52SOB_RS07880	COG1999	signal sequence binding
M52SOB_RS07895	COG1473	amidohydrolase
M52SOB_RS07900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M52SOB_RS07900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M52SOB_RS07920	COG0662	Cupin 2, conserved barrel domain protein
M52SOB_RS07920	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M52SOB_RS07945	COG0318	PFAM AMP-dependent synthetase and ligase
M52SOB_RS08020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M52SOB_RS08030	COG2244	polysaccharide biosynthetic process
M52SOB_RS08060	COG0438	transferase activity, transferring glycosyl groups
M52SOB_RS08090	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
M52SOB_RS08105	COG0367	asparagine synthase
M52SOB_RS08110	COG0438	transferase activity, transferring glycosyl groups
M52SOB_RS08150	COG0726	polysaccharide deacetylase
M52SOB_RS08155	COG3409	Peptidoglycan-binding domain 1 protein
M52SOB_RS08155	COG3267	Type II secretory pathway component ExeA
M52SOB_RS08165	COG0489	protein tyrosine kinase activity
M52SOB_RS08195	COG2204	response regulator
M52SOB_RS08205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M52SOB_RS08210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M52SOB_RS08235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M52SOB_RS08240	COG4591	ABC-type transport system involved in lipoprotein release permease component
M52SOB_RS08245	COG1136	(ABC) transporter
M52SOB_RS08245	COG0577	efflux transmembrane transporter activity
M52SOB_RS08275	COG1136	(ABC) transporter
M52SOB_RS08285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M52SOB_RS08290	COG2197	response regulator
M52SOB_RS08295	COG3850	Histidine kinase
M52SOB_RS08300	COG0494	nUDIX hydrolase
M52SOB_RS08310	COG0183	Belongs to the thiolase family
M52SOB_RS08315	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M52SOB_RS08335	COG1666	GTP binding
M52SOB_RS08340	COG3123	guanosine phosphorylase activity
M52SOB_RS08350	COG0137	argininosuccinate synthase activity
M52SOB_RS08355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M52SOB_RS08360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M52SOB_RS08365	COG0268	Binds directly to 16S ribosomal RNA
M52SOB_RS08370	COG0728	peptidoglycan biosynthetic process
M52SOB_RS08375	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
M52SOB_RS08380	COG0205	6-phosphofructokinase activity
M52SOB_RS08385	COG0563	adenylate kinase activity
M52SOB_RS08390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M52SOB_RS08395	COG2835	tetraacyldisaccharide 4'-kinase activity
M52SOB_RS08400	COG1663	tetraacyldisaccharide 4'-kinase activity
M52SOB_RS08405	COG0848	biopolymer transport protein
M52SOB_RS08410	COG0811	peptide transport
M52SOB_RS08450	COG2221	Nitrite and sulphite reductase 4Fe-4S
M52SOB_RS08455	COG2221	Nitrite and sulphite reductase 4Fe-4S
M52SOB_RS08460	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M52SOB_RS08465	COG2923	Belongs to the DsrF TusC family
M52SOB_RS08470	COG2168	tRNA wobble position uridine thiolation
M52SOB_RS08510	COG1797	cobyrinic acid a,c-diamide synthase activity
M52SOB_RS08520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M52SOB_RS08520	COG1648	precorrin-2 dehydrogenase activity
M52SOB_RS08570	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M52SOB_RS08575	COG1047	Peptidyl-prolyl cis-trans
M52SOB_RS08580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M52SOB_RS08585	COG3744	PilT protein domain protein
M52SOB_RS08595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M52SOB_RS08600	COG0196	riboflavin kinase activity
M52SOB_RS08605	COG0860	N-Acetylmuramoyl-L-alanine amidase
M52SOB_RS08610	COG0802	atpase or kinase
M52SOB_RS08615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M52SOB_RS08635	COG1722	exodeoxyribonuclease VII activity
M52SOB_RS08640	COG0142	geranyltranstransferase activity
M52SOB_RS08645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M52SOB_RS08650	COG1469	GTP cyclohydrolase I activity
M52SOB_RS08655	COG0335	large ribosomal subunit rRNA binding
M52SOB_RS08660	COG0336	Belongs to the RNA methyltransferase TrmD family
M52SOB_RS08665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M52SOB_RS08670	COG0228	four-way junction DNA binding
M52SOB_RS08675	COG2890	protein-(glutamine-N5) methyltransferase activity
M52SOB_RS08680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M52SOB_RS08685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M52SOB_RS08705	COG1136	(ABC) transporter
M52SOB_RS08705	COG0577	efflux transmembrane transporter activity
M52SOB_RS08715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M52SOB_RS08755	COG0348	domain, Protein
M52SOB_RS08770	COG4771	TonB-dependent receptor
M52SOB_RS08815	COG1858	cytochrome C peroxidase
M52SOB_RS08880	COG2226	methyltransferase
M52SOB_RS08890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M52SOB_RS08890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M52SOB_RS08895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M52SOB_RS08905	COG2217	Heavy metal translocating P-type atpase
M52SOB_RS08915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M52SOB_RS08920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M52SOB_RS08925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M52SOB_RS08950	COG3243	poly(R)-hydroxyalkanoic acid synthase
M52SOB_RS08975	COG0348	domain, Protein
M52SOB_RS08995	COG3278	Belongs to the heme-copper respiratory oxidase family
M52SOB_RS09005	COG2217	Heavy metal translocating P-type atpase
M52SOB_RS09025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M52SOB_RS09045	COG3609	addiction module antidote protein, CC2985 family
M52SOB_RS09055	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
M52SOB_RS09225	COG0616	signal peptide processing
M52SOB_RS09285	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M52SOB_RS09290	COG2161	toxin-antitoxin pair type II binding
M52SOB_RS09300	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M52SOB_RS09315	COG3609	addiction module antidote protein, CC2985 family
M52SOB_RS09395	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M52SOB_RS09395	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M52SOB_RS09405	COG2856	Zn peptidase
M52SOB_RS09430	COG2217	Heavy metal translocating P-type atpase
M52SOB_RS09465	COG5002	protein histidine kinase activity
M52SOB_RS09470	COG5001	Diguanylate cyclase
M52SOB_RS09470	COG3300	MHYT domain
M52SOB_RS09480	COG0789	Transcriptional regulator
M52SOB_RS09535	COG1742	UPF0060 membrane protein
M52SOB_RS09700	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M52SOB_RS09740	COG1061	Type III restriction enzyme res subunit
M52SOB_RS09845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M52SOB_RS09855	COG0642	Histidine kinase
M52SOB_RS09865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M52SOB_RS09865	COG0517	IMP dehydrogenase activity
M52SOB_RS09875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M52SOB_RS09885	COG0459	protein refolding
M52SOB_RS09890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M52SOB_RS09915	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M52SOB_RS09920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M52SOB_RS09925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M52SOB_RS09950	COG5265	(ABC) transporter
M52SOB_RS09955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M52SOB_RS09965	COG0765	amino acid transport
M52SOB_RS09970	COG1126	abc transporter atp-binding protein
M52SOB_RS09985	COG0776	regulation of translation
M52SOB_RS09990	COG0072	phenylalanine-tRNA ligase activity
M52SOB_RS09990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M52SOB_RS09995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M52SOB_RS10000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M52SOB_RS10005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M52SOB_RS10010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M52SOB_RS10015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M52SOB_RS10025	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M52SOB_RS10055	COG2010	Cytochrome c
M52SOB_RS10075	COG2010	Cytochrome c
M52SOB_RS10085	COG0535	radical SAM domain protein
M52SOB_RS10095	COG1845	cytochrome c oxidase, subunit III
M52SOB_RS10105	COG2010	Cytochrome c
M52SOB_RS10110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M52SOB_RS10120	COG0584	glycerophosphoryl diester phosphodiesterase
M52SOB_RS10135	COG0513	Belongs to the DEAD box helicase family
M52SOB_RS10150	COG3876	Protein conserved in bacteria
M52SOB_RS10165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M52SOB_RS10170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M52SOB_RS10175	COG0631	protein serine/threonine phosphatase activity
M52SOB_RS10190	COG0247	lactate metabolic process
M52SOB_RS10195	COG0277	FAD linked oxidase domain protein
M52SOB_RS10200	COG0277	FAD linked oxidase domain protein
M52SOB_RS10205	COG3622	Belongs to the hyi family
M52SOB_RS10240	COG3864	Putative metallopeptidase domain
M52SOB_RS10275	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
M52SOB_RS10285	COG2391	methyltransferase activity
M52SOB_RS10295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M52SOB_RS10320	COG3260	NADH ubiquinone oxidoreductase 20
M52SOB_RS10325	COG0649	NAD binding
M52SOB_RS10325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M52SOB_RS10325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M52SOB_RS10330	COG0651	ATP synthesis coupled electron transport
M52SOB_RS10340	COG0650	Formate hydrogenlyase subunit 4
M52SOB_RS10345	COG0651	ATP synthesis coupled electron transport
M52SOB_RS10355	COG0471	metal ion transport
M52SOB_RS10355	COG3273	potassium ion transport
M52SOB_RS10360	COG0659	secondary active sulfate transmembrane transporter activity
M52SOB_RS10370	COG0730	response to heat
M52SOB_RS10375	COG0745	RESPONSE REGULATOR receiver
M52SOB_RS10380	COG0642	Histidine kinase
M52SOB_RS10400	COG0191	fructose-bisphosphate aldolase activity
M52SOB_RS10405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M52SOB_RS10420	COG4451	ribulose bisphosphate carboxylase, small
M52SOB_RS10425	COG1850	ribulose-bisphosphate carboxylase activity
M52SOB_RS10430	COG0583	DNA-binding transcription factor activity
M52SOB_RS10435	COG2096	Adenosyltransferase
M52SOB_RS10440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M52SOB_RS10445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M52SOB_RS10455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M52SOB_RS10460	COG0312	modulator of DNA gyrase
M52SOB_RS10465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M52SOB_RS10475	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M52SOB_RS10480	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M52SOB_RS10495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M52SOB_RS10505	COG2967	ApaG domain
M52SOB_RS10510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M52SOB_RS10515	COG0546	phosphoglycolate phosphatase activity
M52SOB_RS10535	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M52SOB_RS10600	COG0446	pyridine nucleotide-disulphide oxidoreductase
M52SOB_RS10610	COG2205	protein histidine kinase activity
M52SOB_RS10620	COG2204	response regulator
M52SOB_RS10625	COG0512	Glutamine amidotransferase of anthranilate synthase
M52SOB_RS10630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M52SOB_RS10645	COG0134	indole-3-glycerol-phosphate synthase activity
M52SOB_RS10650	COG0191	fructose-bisphosphate aldolase activity
M52SOB_RS10655	COG0469	pyruvate kinase activity
M52SOB_RS10660	COG0126	phosphoglycerate kinase activity
M52SOB_RS10665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M52SOB_RS10670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M52SOB_RS10675	COG3954	Phosphoribulokinase
M52SOB_RS10680	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M52SOB_RS10700	COG1850	ribulose-bisphosphate carboxylase activity
M52SOB_RS10705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M52SOB_RS10730	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M52SOB_RS10740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M52SOB_RS10740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M52SOB_RS10745	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M52SOB_RS10750	COG3657	addiction module killer protein
M52SOB_RS10755	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M52SOB_RS10760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M52SOB_RS10770	COG1487	ribonuclease activity
M52SOB_RS10785	COG0508	dehydrogenase complex catalyzes the overall conversion of
M52SOB_RS10790	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M52SOB_RS10795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M52SOB_RS10800	COG0674	pyruvate-flavodoxin oxidoreductase activity
M52SOB_RS10805	COG1013	pyruvate-flavodoxin oxidoreductase activity
M52SOB_RS10810	COG0493	'glutamate synthase
M52SOB_RS10830	COG4625	pathogenesis
M52SOB_RS10830	COG3240	lipase activity
M52SOB_RS10855	COG1796	DNA polymerase
M52SOB_RS10855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M52SOB_RS10860	COG1067	ATP-dependent peptidase activity
M52SOB_RS10865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M52SOB_RS10870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M52SOB_RS10875	COG0022	dehydrogenase e1 component
M52SOB_RS10875	COG0508	dehydrogenase complex catalyzes the overall conversion of
M52SOB_RS10885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M52SOB_RS10915	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M52SOB_RS10920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M52SOB_RS10925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M52SOB_RS10930	COG0009	L-threonylcarbamoyladenylate synthase
M52SOB_RS10940	COG2226	methyltransferase
M52SOB_RS10955	COG4636	protein conserved in cyanobacteria
M52SOB_RS10960	COG0784	Response regulator, receiver
M52SOB_RS10980	COG4251	negative regulation of phosphorylation
M52SOB_RS11000	COG1335	isochorismatase
M52SOB_RS11010	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M52SOB_RS11030	COG2046	Belongs to the sulfate adenylyltransferase family
M52SOB_RS11035	COG4783	chaperone-mediated protein folding
M52SOB_RS11040	COG0315	cyclic pyranopterin monophosphate synthase activity
M52SOB_RS11060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M52SOB_RS11065	COG0438	transferase activity, transferring glycosyl groups
M52SOB_RS11100	COG2226	methyltransferase
M52SOB_RS11120	COG0529	Catalyzes the synthesis of activated sulfate
M52SOB_RS11195	COG2814	Major facilitator Superfamily
M52SOB_RS11200	COG0629	single-stranded DNA binding
M52SOB_RS11205	COG2358	TRAP transporter, solute receptor (TAXI family
M52SOB_RS11210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M52SOB_RS11215	COG2823	Periplasmic or secreted lipoprotein
M52SOB_RS11220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M52SOB_RS11230	COG0792	nuclease activity
M52SOB_RS11245	COG0418	dihydroorotase activity
M52SOB_RS11260	COG2001	Belongs to the MraZ family
M52SOB_RS11265	COG0275	rRNA processing
M52SOB_RS11270	COG3116	cell division
M52SOB_RS11280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M52SOB_RS11285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M52SOB_RS11290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M52SOB_RS11295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M52SOB_RS11300	COG0772	Belongs to the SEDS family
M52SOB_RS11305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M52SOB_RS11310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M52SOB_RS11315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M52SOB_RS11320	COG1181	Belongs to the D-alanine--D-alanine ligase family
M52SOB_RS11325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M52SOB_RS11340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M52SOB_RS11345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M52SOB_RS11350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M52SOB_RS11355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M52SOB_RS11365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M52SOB_RS11370	COG0006	proline dipeptidase activity
M52SOB_RS11375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M52SOB_RS11385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M52SOB_RS11390	COG0138	bifunctional purine biosynthesis protein purh
M52SOB_RS11395	COG0151	Belongs to the GarS family
M52SOB_RS11400	COG0408	coproporphyrinogen oxidase activity
M52SOB_RS11410	COG2959	enzyme of heme biosynthesis
M52SOB_RS11420	COG0181	hydroxymethylbilane synthase activity
M52SOB_RS11425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M52SOB_RS11430	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M52SOB_RS11440	COG2972	Histidine kinase
M52SOB_RS11440	COG0745	RESPONSE REGULATOR receiver
M52SOB_RS11445	COG0165	Argininosuccinate lyase
M52SOB_RS11450	COG3001	Fructosamine kinase
M52SOB_RS11465	COG1295	ribonuclease BN
M52SOB_RS11475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M52SOB_RS11485	COG0688	phosphatidylethanolamine metabolic process
M52SOB_RS11490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M52SOB_RS11495	COG0440	acetolactate synthase activity
M52SOB_RS11500	COG0028	Belongs to the TPP enzyme family
M52SOB_RS11525	COG0795	lipopolysaccharide-transporting ATPase activity
M52SOB_RS11530	COG0795	lipopolysaccharide-transporting ATPase activity
M52SOB_RS11535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M52SOB_RS11550	COG0525	valine-tRNA ligase activity
M52SOB_RS11555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M52SOB_RS11560	COG0671	phosphoesterase, PA-phosphatase related
M52SOB_RS11565	COG0463	Glycosyl transferase, family 2
M52SOB_RS11585	COG2210	Belongs to the sulfur carrier protein TusA family
M52SOB_RS11590	COG0425	Belongs to the sulfur carrier protein TusA family
M52SOB_RS11595	COG3302	dmso reductase anchor subunit
M52SOB_RS11600	COG0437	4 iron, 4 sulfur cluster binding
M52SOB_RS11605	COG0243	molybdopterin cofactor binding
M52SOB_RS11635	COG1233	COG1233 Phytoene dehydrogenase and related
M52SOB_RS11640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M52SOB_RS11645	COG2048	Heterodisulfide reductase, subunit B
M52SOB_RS11675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M52SOB_RS11680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M52SOB_RS11695	COG2423	ornithine cyclodeaminase activity
M52SOB_RS11700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M52SOB_RS11705	COG0045	succinate-CoA ligase (ADP-forming) activity
M52SOB_RS11730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M52SOB_RS11735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M52SOB_RS11745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M52SOB_RS11750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M52SOB_RS11760	COG0140	phosphoribosyl-ATP diphosphatase activity
M52SOB_RS11765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M52SOB_RS11770	COG0107	imidazoleglycerol-phosphate synthase activity
M52SOB_RS11775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M52SOB_RS11780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M52SOB_RS11785	COG0131	Imidazoleglycerol-phosphate dehydratase
M52SOB_RS11790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M52SOB_RS11795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M52SOB_RS11815	COG5007	Belongs to the BolA IbaG family
M52SOB_RS11830	COG2853	Lipoprotein
M52SOB_RS11835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M52SOB_RS11840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M52SOB_RS11845	COG1127	ABC transporter
M52SOB_RS11855	COG3409	Peptidoglycan-binding domain 1 protein
M52SOB_RS11855	COG3267	Type II secretory pathway component ExeA
M52SOB_RS11875	COG1459	type II secretion system
M52SOB_RS11905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M52SOB_RS11910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M52SOB_RS11915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M52SOB_RS11920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M52SOB_RS11950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M52SOB_RS11960	COG0316	Belongs to the HesB IscA family
M52SOB_RS11975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M52SOB_RS11980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M52SOB_RS11985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M52SOB_RS11990	COG1765	OsmC-like protein
M52SOB_RS11995	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M52SOB_RS12005	COG0494	nUDIX hydrolase
M52SOB_RS12010	COG0442	prolyl-tRNA aminoacylation
M52SOB_RS12015	COG0741	lytic transglycosylase activity
M52SOB_RS12020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M52SOB_RS12030	COG4536	flavin adenine dinucleotide binding
M52SOB_RS12055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M52SOB_RS12070	COG0494	nUDIX hydrolase
M52SOB_RS12075	COG0071	Belongs to the small heat shock protein (HSP20) family
M52SOB_RS12080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M52SOB_RS12090	COG1309	transcriptional regulator
M52SOB_RS12100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M52SOB_RS12110	COG2205	protein histidine kinase activity
M52SOB_RS12110	COG5002	protein histidine kinase activity
M52SOB_RS12110	COG0784	Response regulator, receiver
M52SOB_RS12115	COG2226	methyltransferase
M52SOB_RS12120	COG1040	competence protein
M52SOB_RS12135	COG3409	Peptidoglycan-binding domain 1 protein
M52SOB_RS12135	COG3267	Type II secretory pathway component ExeA
M52SOB_RS12140	COG1450	Type ii and iii secretion system protein
M52SOB_RS12165	COG4770	biotin carboxylase activity
M52SOB_RS12170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M52SOB_RS12175	COG1703	isobutyryl-CoA mutase activity
M52SOB_RS12190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M52SOB_RS12190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M52SOB_RS12200	COG0446	pyridine nucleotide-disulphide oxidoreductase
M52SOB_RS12205	COG1024	Enoyl-CoA hydratase
M52SOB_RS12215	COG1011	Hydrolase
M52SOB_RS12235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M52SOB_RS12240	COG0129	dihydroxy-acid dehydratase activity
M52SOB_RS12255	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M52SOB_RS12260	COG1331	Highly conserved protein containing a thioredoxin domain
M52SOB_RS12265	COG4654	Cytochrome c, class I
M52SOB_RS12270	COG4566	intracellular signal transduction
M52SOB_RS12275	COG4191	Histidine kinase
M52SOB_RS12280	COG2855	membrane
M52SOB_RS12305	COG0411	ABC transporter
M52SOB_RS12335	COG1981	membrane
M52SOB_RS12370	COG0762	integral membrane protein
M52SOB_RS12375	COG1872	DUF167
M52SOB_RS12380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M52SOB_RS12390	COG0012	GTP binding
M52SOB_RS12395	COG0193	aminoacyl-tRNA hydrolase activity
M52SOB_RS12400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M52SOB_RS12405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M52SOB_RS12415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M52SOB_RS12420	COG1940	carbohydrate kinase activity
M52SOB_RS12435	COG1127	ABC transporter
M52SOB_RS12445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M52SOB_RS12450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M52SOB_RS12455	COG0205	6-phosphofructokinase activity
M52SOB_RS12460	COG2119	membrane
M52SOB_RS12470	COG0569	domain protein
M52SOB_RS12475	COG2204	response regulator
M52SOB_RS12490	COG5000	phosphorelay sensor kinase activity
M52SOB_RS12510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M52SOB_RS12525	COG0758	DNA mediated transformation
M52SOB_RS12530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M52SOB_RS12530	COG0551	DNA topoisomerase type I activity
M52SOB_RS12540	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M52SOB_RS12550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M52SOB_RS12555	COG0646	methionine synthase
M52SOB_RS12555	COG1410	methionine synthase
M52SOB_RS12565	COG1968	undecaprenyl-diphosphatase activity
M52SOB_RS12570	COG3150	esterase
M52SOB_RS12590	COG0651	ATP synthesis coupled electron transport
M52SOB_RS12595	COG0651	ATP synthesis coupled electron transport
M52SOB_RS12615	COG1320	monovalent cation:proton antiporter activity
M52SOB_RS12645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M52SOB_RS12650	COG0598	Magnesium transport protein CorA
M52SOB_RS12655	COG0406	alpha-ribazole phosphatase activity
M52SOB_RS12660	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M52SOB_RS12665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M52SOB_RS12680	COG1294	oxidase, subunit
M52SOB_RS12695	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M52SOB_RS12700	COG0512	Glutamine amidotransferase of anthranilate synthase
M52SOB_RS12700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M52SOB_RS12705	COG1492	cobalamin metabolic process
M52SOB_RS12710	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M52SOB_RS12720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M52SOB_RS12730	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M52SOB_RS12735	COG1797	cobyrinic acid a,c-diamide synthase activity
M52SOB_RS12745	COG1120	ATPase activity
M52SOB_RS12750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M52SOB_RS12755	COG4206	TonB-dependent receptor
M52SOB_RS12780	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M52SOB_RS12790	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M52SOB_RS12825	COG2022	thiamine diphosphate biosynthetic process
M52SOB_RS12835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M52SOB_RS12840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M52SOB_RS12845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M52SOB_RS12850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M52SOB_RS12860	COG1561	YicC-like family, N-terminal region
M52SOB_RS12905	COG0194	GDP metabolic process
M52SOB_RS12910	COG1758	RNA polymerase activity
M52SOB_RS12915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M52SOB_RS12935	COG0243	molybdopterin cofactor binding
M52SOB_RS12940	COG0437	4 iron, 4 sulfur cluster binding
M52SOB_RS12945	COG0348	domain, Protein
M52SOB_RS12970	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M52SOB_RS12975	COG4235	cytochrome complex assembly
M52SOB_RS12980	COG3088	subunit of a heme lyase
M52SOB_RS12985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M52SOB_RS12995	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M52SOB_RS13015	COG4133	protoheme IX ABC transporter activity
M52SOB_RS13020	COG2878	Part of a membrane complex involved in electron transport
M52SOB_RS13025	COG1013	pyruvate-flavodoxin oxidoreductase activity
M52SOB_RS13025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M52SOB_RS13025	COG0674	pyruvate-flavodoxin oxidoreductase activity
M52SOB_RS13025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M52SOB_RS13030	COG4656	Part of a membrane complex involved in electron transport
M52SOB_RS13035	COG4658	electron transport chain
M52SOB_RS13045	COG4660	Part of a membrane complex involved in electron transport
M52SOB_RS13050	COG4657	Part of a membrane complex involved in electron transport
M52SOB_RS13090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M52SOB_RS13110	COG4584	PFAM Integrase catalytic
M52SOB_RS13115	COG1484	DNA-dependent DNA replication
M52SOB_RS13135	COG0730	response to heat
M52SOB_RS13150	COG0489	protein tyrosine kinase activity
M52SOB_RS13155	COG0281	malic enzyme
M52SOB_RS13155	COG0280	phosphate acetyltransferase
M52SOB_RS13160	COG1192	Involved in chromosome partitioning
M52SOB_RS13165	COG2267	carboxylic ester hydrolase activity
M52SOB_RS13175	COG0210	DNA helicase
M52SOB_RS13185	COG3706	GGDEF domain
M52SOB_RS13190	COG0495	leucyl-tRNA aminoacylation
M52SOB_RS13205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M52SOB_RS13225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M52SOB_RS13230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M52SOB_RS13235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M52SOB_RS13265	COG0791	NLP P60 protein
M52SOB_RS13280	COG0412	Dienelactone hydrolase
M52SOB_RS13290	COG0424	maF-like protein
M52SOB_RS13295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M52SOB_RS13300	COG0799	negative regulation of ribosome biogenesis
M52SOB_RS13305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M52SOB_RS13340	COG0577	efflux transmembrane transporter activity
M52SOB_RS13340	COG1136	(ABC) transporter
M52SOB_RS13345	COG1136	(ABC) transporter
M52SOB_RS13345	COG0577	efflux transmembrane transporter activity
M52SOB_RS13350	COG1136	(ABC) transporter
M52SOB_RS13350	COG0577	efflux transmembrane transporter activity
M52SOB_RS13355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M52SOB_RS13365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M52SOB_RS13370	COG0352	thiamine-phosphate diphosphorylase activity
M52SOB_RS13375	COG0351	phosphomethylpyrimidine kinase
M52SOB_RS13380	COG0415	Belongs to the DNA photolyase family
M52SOB_RS13385	COG1678	Uncharacterized ACR, COG1678
M52SOB_RS13390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M52SOB_RS13400	COG0540	Belongs to the ATCase OTCase family
M52SOB_RS13405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M52SOB_RS13435	COG2814	Major facilitator Superfamily
M52SOB_RS13440	COG0606	chelatase, subunit chli
M52SOB_RS13445	COG2960	long-chain fatty acid transporting porin activity
M52SOB_RS13460	COG0004	ammonium transporteR
M52SOB_RS13475	COG0840	transmembrane signaling receptor activity
M52SOB_RS13480	COG0488	(ABC) transporter
M52SOB_RS13505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M52SOB_RS13510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M52SOB_RS13515	COG0791	NLP P60 protein
M52SOB_RS13520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M52SOB_RS13525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M52SOB_RS13525	COG2813	Specifically methylates the guanine in position
M52SOB_RS13545	COG2945	thiolester hydrolase activity
M52SOB_RS13570	COG3154	lipid carrier protein
M52SOB_RS13575	COG0826	peptidase U32
M52SOB_RS13585	COG2442	InterPro IPR007367
M52SOB_RS13590	COG0826	peptidase U32
M52SOB_RS13595	COG0300	oxidoreductase activity
M52SOB_RS13600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M52SOB_RS13610	COG0018	arginyl-trna synthetase
M52SOB_RS13635	COG0247	lactate metabolic process
M52SOB_RS13660	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M52SOB_RS13665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M52SOB_RS13670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M52SOB_RS13675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M52SOB_RS13680	COG1546	Belongs to the CinA family
M52SOB_RS13685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M52SOB_RS13690	COG2137	regulation of response to DNA damage stimulus
M52SOB_RS13695	COG1137	ATPase activity
M52SOB_RS13700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M52SOB_RS13705	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M52SOB_RS13710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M52SOB_RS13715	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M52SOB_RS13725	COG2226	methyltransferase
M52SOB_RS13740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M52SOB_RS13745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M52SOB_RS13750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M52SOB_RS13755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M52SOB_RS13760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M52SOB_RS13775	COG0356	it plays a direct role in the translocation of protons across the membrane
M52SOB_RS13790	COG1192	Involved in chromosome partitioning
M52SOB_RS13795	COG0357	Ribosomal RNA small subunit methyltransferase G
M52SOB_RS13800	COG0445	tRNA wobble uridine modification
M52SOB_RS13825	COG0730	response to heat
M52SOB_RS13830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M52SOB_RS13835	COG0706	membrane insertase activity
M52SOB_RS13840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M52SOB_RS13845	COG0594	ribonuclease P activity
M52SOB_RS13850	COG0230	Belongs to the bacterial ribosomal protein bL34 family