locus-tag	class	description
SLY_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SLY_RS00040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SLY_RS00085	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SLY_RS00090	COG1393	Belongs to the ArsC family
SLY_RS00110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SLY_RS00120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SLY_RS00130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SLY_RS00150	COG3842	ATPase activity
SLY_RS00155	COG0017	Asparaginyl-tRNA synthetase
SLY_RS00190	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS00195	COG2801	Transposase and inactivated derivatives
SLY_RS00225	COG2801	Transposase and inactivated derivatives
SLY_RS00250	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS00260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS00320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS00335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SLY_RS00350	COG0148	phosphopyruvate hydratase activity
SLY_RS00355	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SLY_RS00360	COG0469	pyruvate kinase activity
SLY_RS00375	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SLY_RS00380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SLY_RS00395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SLY_RS00400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SLY_RS00405	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SLY_RS00410	COG1307	EDD domain protein, DegV family
SLY_RS00420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SLY_RS00425	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS00505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS00515	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS00550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SLY_RS00565	COG2217	Heavy metal translocating P-type atpase
SLY_RS00570	COG2088	sporulation resulting in formation of a cellular spore
SLY_RS00575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SLY_RS00580	COG1078	dGTPase activity
SLY_RS00585	COG4869	propanediol catabolic process
SLY_RS00625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS00680	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS00690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS00800	COG2801	Transposase and inactivated derivatives
SLY_RS00815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SLY_RS00820	COG0012	GTP binding
SLY_RS00825	COG1162	GTPase activity
SLY_RS00900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS00910	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS00935	COG2801	Transposase and inactivated derivatives
SLY_RS00940	COG2801	Transposase and inactivated derivatives
SLY_RS00945	COG2801	Transposase and inactivated derivatives
SLY_RS00960	COG0513	Belongs to the DEAD box helicase family
SLY_RS00965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLY_RS00970	COG0196	riboflavin kinase activity
SLY_RS00975	COG0322	excinuclease ABC activity
SLY_RS00980	COG0556	nucleotide-excision repair
SLY_RS01085	COG1121	(ABC) transporter
SLY_RS01090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SLY_RS01095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SLY_RS01100	COG0124	histidyl-tRNA synthetase
SLY_RS01105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SLY_RS01110	COG0037	tRNA processing
SLY_RS01115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS01120	COG0564	pseudouridine synthase activity
SLY_RS01125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SLY_RS01140	COG3870	Protein conserved in bacteria
SLY_RS01145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SLY_RS01155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SLY_RS01160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SLY_RS01165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SLY_RS01170	COG0215	cysteine-tRNA ligase activity
SLY_RS01175	COG0778	Nitroreductase
SLY_RS01185	COG3763	UPF0154 protein
SLY_RS01190	COG0742	ribosomal rna small subunit methyltransferase
SLY_RS01205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SLY_RS01210	COG4122	O-methyltransferase activity
SLY_RS01215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SLY_RS01220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SLY_RS01230	COG0126	phosphoglycerate kinase activity
SLY_RS01235	COG0191	fructose-bisphosphate aldolase activity
SLY_RS01245	COG0149	triose-phosphate isomerase activity
SLY_RS01250	COG4589	Belongs to the CDS family
SLY_RS01255	COG0233	cytoplasmic translational termination
SLY_RS01260	COG0528	UMP kinase activity
SLY_RS01265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SLY_RS01270	COG0052	Belongs to the universal ribosomal protein uS2 family
SLY_RS01275	COG0756	dUTP diphosphatase activity
SLY_RS01280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SLY_RS01290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS01325	COG0577	efflux transmembrane transporter activity
SLY_RS01325	COG1136	(ABC) transporter
SLY_RS01330	COG0072	phenylalanine-tRNA ligase activity
SLY_RS01335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SLY_RS01360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SLY_RS01365	COG0095	Lipoate-protein ligase
SLY_RS01375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS01380	COG0018	arginyl-trna synthetase
SLY_RS01390	COG2176	DNA-directed DNA polymerase activity
SLY_RS01395	COG0180	Tryptophanyl-tRNA synthetase
SLY_RS01410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SLY_RS01415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SLY_RS01420	COG0335	large ribosomal subunit rRNA binding
SLY_RS01425	COG0336	Belongs to the RNA methyltransferase TrmD family
SLY_RS01430	COG0228	four-way junction DNA binding
SLY_RS01435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SLY_RS01440	COG0653	protein targeting
SLY_RS01455	COG0443	Heat shock 70 kDa protein
SLY_RS01460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SLY_RS01465	COG1420	regulation of RNA biosynthetic process
SLY_RS01475	COG0203	ribosomal protein L17
SLY_RS01480	COG0202	RNA polymerase activity
SLY_RS01485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SLY_RS01490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SLY_RS01495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SLY_RS01500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SLY_RS01505	COG0024	Methionine aminopeptidase
SLY_RS01510	COG0563	adenylate kinase activity
SLY_RS01515	COG0201	protein transport
SLY_RS01520	COG0200	Binds to the 23S rRNA
SLY_RS01525	COG1841	ribosomal large subunit assembly
SLY_RS01530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SLY_RS01535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SLY_RS01540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SLY_RS01545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SLY_RS01550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SLY_RS01555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SLY_RS01560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SLY_RS01565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SLY_RS01570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SLY_RS01575	COG0255	Belongs to the universal ribosomal protein uL29 family
SLY_RS01580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SLY_RS01585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SLY_RS01595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SLY_RS01600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SLY_RS01605	COG0089	rRNA binding
SLY_RS01610	COG0088	Forms part of the polypeptide exit tunnel
SLY_RS01615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SLY_RS01620	COG0051	transcription antitermination factor activity, RNA binding
SLY_RS01625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SLY_RS01635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SLY_RS01640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SLY_RS01650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SLY_RS01655	COG1054	Belongs to the UPF0176 family
SLY_RS01660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SLY_RS01675	COG0268	Binds directly to 16S ribosomal RNA
SLY_RS01685	COG0301	tRNA thio-modification
SLY_RS01695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SLY_RS01705	COG2251	uridine kinase activity
SLY_RS01710	COG0195	Participates in both transcription termination and antitermination
SLY_RS01720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SLY_RS01725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SLY_RS01730	COG0193	aminoacyl-tRNA hydrolase activity
SLY_RS01735	COG1253	flavin adenine dinucleotide binding
SLY_RS01750	COG0358	DNA primase activity
SLY_RS01755	COG0423	glycine-tRNA ligase activity
SLY_RS01760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SLY_RS01765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SLY_RS01770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SLY_RS01785	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SLY_RS01800	COG1183	phosphatidylcholine synthase activity
SLY_RS01805	COG0688	phosphatidylethanolamine metabolic process
SLY_RS01810	COG0504	CTP synthase activity
SLY_RS01825	COG0571	ribonuclease III activity
SLY_RS01830	COG0416	fatty acid biosynthetic process
SLY_RS01855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SLY_RS01860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SLY_RS01865	COG1692	metallophosphoesterase
SLY_RS01870	COG1418	mRNA catabolic process
SLY_RS01895	COG0445	tRNA wobble uridine modification
SLY_RS01900	COG0357	Ribosomal RNA small subunit methyltransferase G
SLY_RS01905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS01930	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS01940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS01945	COG2801	Transposase and inactivated derivatives
SLY_RS01950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SLY_RS01955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SLY_RS01960	COG0049	tRNA binding
SLY_RS01965	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SLY_RS01970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SLY_RS01975	COG0085	RNA polymerase activity
SLY_RS01980	COG0222	ribosome binding
SLY_RS01985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SLY_RS01990	COG0081	regulation of translation
SLY_RS01995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SLY_RS02010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SLY_RS02015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SLY_RS02020	COG1185	polyribonucleotide nucleotidyltransferase activity
SLY_RS02060	COG0594	ribonuclease P activity
SLY_RS02065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SLY_RS02070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SLY_RS02085	COG0006	proline dipeptidase activity
SLY_RS02090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SLY_RS02105	COG0776	regulation of translation
SLY_RS02110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SLY_RS02155	COG0084	hydrolase, TatD family'
SLY_RS02175	COG0210	DNA helicase
SLY_RS02200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SLY_RS02205	COG0544	peptidyl-prolyl cis-trans isomerase activity
SLY_RS02210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SLY_RS02220	COG0312	modulator of DNA gyrase
SLY_RS02230	COG0537	adenosine 5'-monophosphoramidase activity
SLY_RS02240	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SLY_RS02250	COG3481	metal-dependent phosphohydrolase, HD sub domain
SLY_RS02255	COG0617	tRNA 3'-terminal CCA addition
SLY_RS02260	COG0590	tRNA wobble adenosine to inosine editing
SLY_RS02265	COG1435	thymidine kinase activity
SLY_RS02270	COG0254	rRNA binding
SLY_RS02275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SLY_RS02285	COG0071	Belongs to the small heat shock protein (HSP20) family
SLY_RS02290	COG4608	Belongs to the ABC transporter superfamily
SLY_RS02295	COG2801	Transposase and inactivated derivatives
SLY_RS02350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS02355	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS02365	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS02365	COG1372	Participates in initiation and elongation during chromosome replication
SLY_RS02420	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS02430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS02535	COG2801	Transposase and inactivated derivatives
SLY_RS02590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS02630	COG0776	regulation of translation
SLY_RS02650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS02660	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS02695	COG2801	Transposase and inactivated derivatives
SLY_RS02705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS02715	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS02735	COG4608	Belongs to the ABC transporter superfamily
SLY_RS02740	COG0444	Belongs to the ABC transporter superfamily
SLY_RS02755	COG0601	transmembrane transport
SLY_RS02760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLY_RS02765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SLY_RS02770	COG0459	protein refolding
SLY_RS02785	COG0482	sulfurtransferase activity
SLY_RS02790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SLY_RS02795	COG3493	citrate carrier protein
SLY_RS02800	COG0281	malic enzyme
SLY_RS02805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SLY_RS02810	COG1481	regulation of sporulation
SLY_RS02850	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS02860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS02895	COG0776	regulation of translation
SLY_RS02935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS02965	COG2801	Transposase and inactivated derivatives
SLY_RS02970	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS02990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS03045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS03055	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS03070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SLY_RS03075	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SLY_RS03085	COG1122	ATPase activity
SLY_RS03110	COG0187	DNA topoisomerase II activity
SLY_RS03115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SLY_RS03120	COG0802	atpase or kinase
SLY_RS03125	COG1214	PFAM Peptidase M22, glycoprotease
SLY_RS03125	COG0456	acetyltransferase
SLY_RS03155	COG0481	GTPase activity
SLY_RS03175	COG2801	Transposase and inactivated derivatives
SLY_RS03190	COG2801	Transposase and inactivated derivatives
SLY_RS03210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS03265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS03275	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS03290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SLY_RS03295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SLY_RS03300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SLY_RS03310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SLY_RS03320	COG0495	leucyl-tRNA aminoacylation
SLY_RS03325	COG0194	GDP metabolic process
SLY_RS03330	COG1758	RNA polymerase activity
SLY_RS03335	COG0275	rRNA processing
SLY_RS03360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SLY_RS03370	COG1132	(ABC) transporter
SLY_RS03375	COG1132	(ABC) transporter
SLY_RS03380	COG2801	Transposase and inactivated derivatives
SLY_RS03480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS03490	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS03510	COG1272	protein, Hemolysin III
SLY_RS03515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SLY_RS03530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SLY_RS03550	COG2801	Transposase and inactivated derivatives
SLY_RS03555	COG2801	Transposase and inactivated derivatives
SLY_RS03570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS03580	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS03600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLY_RS03600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLY_RS03605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SLY_RS03625	COG1177	transmembrane transport
SLY_RS03630	COG1176	ABC-type spermidine putrescine transport system, permease component I
SLY_RS03635	COG3839	Belongs to the ABC transporter superfamily
SLY_RS03645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLY_RS03650	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SLY_RS03655	COG1122	ATPase activity
SLY_RS03660	COG4720	Psort location CytoplasmicMembrane, score
SLY_RS03665	COG0525	valine-tRNA ligase activity
SLY_RS03670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SLY_RS03685	COG0009	L-threonylcarbamoyladenylate synthase
SLY_RS03690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SLY_RS03695	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS03700	COG0359	binds to the 23S rRNA
SLY_RS03700	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SLY_RS03705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SLY_RS03710	COG0629	single-stranded DNA binding
SLY_RS03715	COG0360	Binds together with S18 to 16S ribosomal RNA
SLY_RS03735	COG2801	Transposase and inactivated derivatives
SLY_RS03745	COG0513	Belongs to the DEAD box helicase family
SLY_RS03780	COG0205	6-phosphofructokinase activity
SLY_RS03790	COG0166	Belongs to the GPI family
SLY_RS03795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SLY_RS03805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS03810	COG0101	tRNA pseudouridine synthase activity
SLY_RS03820	COG2801	Transposase and inactivated derivatives
SLY_RS03840	COG2801	Transposase and inactivated derivatives
SLY_RS03925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS03935	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS03965	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS03975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS04010	COG0776	regulation of translation
SLY_RS04050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS04095	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS04105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS04185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS04215	COG2801	Transposase and inactivated derivatives
SLY_RS04230	COG1126	abc transporter atp-binding protein
SLY_RS04250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SLY_RS04255	COG1160	GTP binding
SLY_RS04260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SLY_RS04265	COG1187	pseudouridine synthase activity
SLY_RS04270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SLY_RS04295	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS04305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS04380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SLY_RS04445	COG1484	DNA-dependent DNA replication
SLY_RS04455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SLY_RS04460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLY_RS04460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLY_RS04470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SLY_RS04475	COG0552	protein localization to endoplasmic reticulum
SLY_RS04500	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS04510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS04530	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS04540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS04545	COG0305	Participates in initiation and elongation during chromosome replication
SLY_RS04555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLY_RS04615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLY_RS04640	COG2801	Transposase and inactivated derivatives
SLY_RS04645	COG2801	Transposase and inactivated derivatives
SLY_RS04755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SLY_RS04765	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLY_RS04770	COG0736	holo-[acyl-carrier-protein] synthase activity