locus-tag	class	description
C7M71_RS00325	COG4977	sequence-specific DNA binding
C7M71_RS00345	COG1802	Transcriptional regulator
C7M71_RS00350	COG1024	Enoyl-CoA hydratase
C7M71_RS00355	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS00390	COG0183	Belongs to the thiolase family
C7M71_RS00400	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS00405	COG1024	Enoyl-CoA hydratase
C7M71_RS00410	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS00415	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS00420	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS00425	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS00430	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS00435	COG1024	Enoyl-CoA hydratase
C7M71_RS00470	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS00475	COG1024	Enoyl-CoA hydratase
C7M71_RS00485	COG2188	Transcriptional regulator
C7M71_RS00500	COG0183	Belongs to the thiolase family
C7M71_RS00515	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS00520	COG1024	Enoyl-CoA hydratase
C7M71_RS00525	COG1024	Enoyl-CoA hydratase
C7M71_RS00530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7M71_RS00540	COG0183	Belongs to the thiolase family
C7M71_RS00550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C7M71_RS00565	COG1024	Enoyl-CoA hydratase
C7M71_RS00570	COG2188	Transcriptional regulator
C7M71_RS00580	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS00590	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS00600	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS00635	COG1309	transcriptional regulator
C7M71_RS00640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7M71_RS00650	COG1802	Transcriptional regulator
C7M71_RS00665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS00670	COG1946	Acyl-CoA thioesterase
C7M71_RS00675	COG0783	Belongs to the Dps family
C7M71_RS00680	COG0114	fumarate hydratase activity
C7M71_RS00695	COG3961	Belongs to the TPP enzyme family
C7M71_RS00710	COG2130	NADP-dependent
C7M71_RS00775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7M71_RS00780	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS00795	COG0577	efflux transmembrane transporter activity
C7M71_RS00795	COG1136	(ABC) transporter
C7M71_RS00825	COG4266	Belongs to the allantoicase family
C7M71_RS00830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7M71_RS00845	COG1414	Transcriptional regulator
C7M71_RS00870	COG2223	nitrite transmembrane transporter activity
C7M71_RS00875	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS00900	COG0765	amino acid transport
C7M71_RS00905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M71_RS00910	COG1404	Belongs to the peptidase S8 family
C7M71_RS00930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C7M71_RS00935	COG1116	anion transmembrane transporter activity
C7M71_RS00955	COG0402	S-adenosylhomocysteine deaminase activity
C7M71_RS00995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C7M71_RS01000	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C7M71_RS01005	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C7M71_RS01010	COG1070	Carbohydrate kinase
C7M71_RS01015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C7M71_RS01035	COG1129	ABC transporter
C7M71_RS01045	COG2188	Transcriptional regulator
C7M71_RS01055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7M71_RS01090	COG0531	amino acid
C7M71_RS01100	COG0589	response to stress
C7M71_RS01105	COG2326	polyphosphate kinase activity
C7M71_RS01115	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS01120	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS01145	COG2030	dehydratase
C7M71_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS01155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7M71_RS01160	COG0183	Belongs to the thiolase family
C7M71_RS01165	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS01170	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS01180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS01190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7M71_RS01200	COG1024	Enoyl-CoA hydratase
C7M71_RS01250	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS01320	COG1278	Cold shock
C7M71_RS01325	COG4555	ABC transporter
C7M71_RS01340	COG0509	glycine decarboxylation via glycine cleavage system
C7M71_RS01350	COG0443	Heat shock 70 kDa protein
C7M71_RS01355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7M71_RS01360	COG0659	secondary active sulfate transmembrane transporter activity
C7M71_RS01420	COG1215	transferase activity, transferring glycosyl groups
C7M71_RS01430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C7M71_RS01455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7M71_RS01460	COG1461	Dihydroxyacetone kinase
C7M71_RS01465	COG2376	Dihydroxyacetone kinase
C7M71_RS01475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7M71_RS01515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7M71_RS01520	COG1993	acr, cog1993
C7M71_RS01525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7M71_RS01530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C7M71_RS01550	COG0583	DNA-binding transcription factor activity
C7M71_RS01560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C7M71_RS01565	COG1126	abc transporter atp-binding protein
C7M71_RS01575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M71_RS01590	COG0831	urea catabolic process
C7M71_RS01595	COG0832	Belongs to the urease beta subunit family
C7M71_RS01600	COG0804	urea catabolic process
C7M71_RS01610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C7M71_RS01615	COG0829	nickel cation binding
C7M71_RS01635	COG0583	DNA-binding transcription factor activity
C7M71_RS01650	COG0542	response to heat
C7M71_RS01680	COG0586	Pfam SNARE associated Golgi protein
C7M71_RS01700	COG1119	ATPase activity
C7M71_RS01710	COG0656	L-ascorbic acid biosynthetic process
C7M71_RS01720	COG3397	chitin binding
C7M71_RS01730	COG0367	asparagine synthase
C7M71_RS01790	COG0745	RESPONSE REGULATOR receiver
C7M71_RS01805	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS01815	COG1595	DNA-templated transcription, initiation
C7M71_RS01820	COG1132	(ABC) transporter
C7M71_RS01830	COG0242	peptide deformylase activity
C7M71_RS01840	COG3442	glutamine amidotransferase
C7M71_RS01845	COG0205	6-phosphofructokinase activity
C7M71_RS01865	COG0791	NLP P60 protein
C7M71_RS01865	COG0741	lytic transglycosylase activity
C7M71_RS01890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7M71_RS01895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C7M71_RS01900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C7M71_RS01930	COG2264	protein methyltransferase activity
C7M71_RS01945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7M71_RS01950	COG1940	carbohydrate kinase activity
C7M71_RS01955	COG2188	Transcriptional regulator
C7M71_RS02020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7M71_RS02030	COG0076	glutamate decarboxylase activity
C7M71_RS02040	COG4122	O-methyltransferase activity
C7M71_RS02080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C7M71_RS02085	COG1053	succinate dehydrogenase
C7M71_RS02095	COG0583	DNA-binding transcription factor activity
C7M71_RS02130	COG0242	peptide deformylase activity
C7M71_RS02150	COG1846	Transcriptional regulator
C7M71_RS02150	COG1940	carbohydrate kinase activity
C7M71_RS02155	COG2223	nitrite transmembrane transporter activity
C7M71_RS02165	COG0398	Pfam SNARE associated Golgi protein
C7M71_RS02190	COG2378	regulation of single-species biofilm formation
C7M71_RS02205	COG1799	cell septum assembly
C7M71_RS02215	COG0477	Major facilitator Superfamily
C7M71_RS02220	COG3958	Transketolase
C7M71_RS02225	COG3959	Transketolase, thiamine diphosphate binding domain
C7M71_RS02230	COG0789	Transcriptional regulator
C7M71_RS02245	COG0667	Aldo Keto reductase
C7M71_RS02260	COG0583	DNA-binding transcription factor activity
C7M71_RS02265	COG0156	8-amino-7-oxononanoate synthase activity
C7M71_RS02270	COG1063	alcohol dehydrogenase
C7M71_RS02275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C7M71_RS02340	COG4585	Histidine kinase
C7M71_RS02345	COG2197	response regulator
C7M71_RS02360	COG3903	Transcriptional regulator
C7M71_RS02360	COG3629	intracellular signal transduction
C7M71_RS02365	COG1609	Transcriptional regulator
C7M71_RS02390	COG1609	Transcriptional regulator
C7M71_RS02410	COG1132	(ABC) transporter
C7M71_RS02435	COG0736	holo-[acyl-carrier-protein] synthase activity
C7M71_RS02450	COG2226	methyltransferase
C7M71_RS02460	COG0596	Alpha beta hydrolase
C7M71_RS02485	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS02505	COG0366	Alpha amylase catalytic
C7M71_RS02505	COG1874	Beta-galactosidase
C7M71_RS02510	COG0542	response to heat
C7M71_RS02525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7M71_RS02530	COG0443	Heat shock 70 kDa protein
C7M71_RS02540	COG3458	cephalosporin-C deacetylase activity
C7M71_RS02560	COG1175	transmembrane transport
C7M71_RS02615	COG1131	(ABC) transporter
C7M71_RS02665	COG0612	Peptidase, M16
C7M71_RS02670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS02730	COG2208	phosphoserine phosphatase activity
C7M71_RS02790	COG1017	nitric oxide dioxygenase activity
C7M71_RS02790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7M71_RS02840	COG1597	lipid kinase activity
C7M71_RS02845	COG3629	intracellular signal transduction
C7M71_RS02845	COG3903	Transcriptional regulator
C7M71_RS02895	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C7M71_RS02920	COG0477	Major facilitator Superfamily
C7M71_RS02930	COG2017	converts alpha-aldose to the beta-anomer
C7M71_RS02955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7M71_RS02965	COG0477	Major facilitator Superfamily
C7M71_RS02975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C7M71_RS03015	COG0477	Major facilitator Superfamily
C7M71_RS03025	COG0412	Dienelactone hydrolase
C7M71_RS03035	COG0259	pyridoxamine-phosphate oxidase activity
C7M71_RS03070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C7M71_RS03085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7M71_RS03085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7M71_RS03095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7M71_RS03100	COG2949	membrane
C7M71_RS03140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C7M71_RS03175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7M71_RS03180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7M71_RS03190	COG2040	homocysteine
C7M71_RS03195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C7M71_RS03200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C7M71_RS03210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C7M71_RS03255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C7M71_RS03260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C7M71_RS03265	COG1984	allophanate hydrolase subunit 2
C7M71_RS03305	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS03330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7M71_RS03345	COG0477	Major facilitator Superfamily
C7M71_RS03350	COG3795	YCII-related domain
C7M71_RS03355	COG4941	Belongs to the sigma-70 factor family
C7M71_RS03360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7M71_RS03370	COG0726	polysaccharide deacetylase
C7M71_RS03380	COG0726	polysaccharide deacetylase
C7M71_RS03390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C7M71_RS03390	COG1796	DNA polymerase
C7M71_RS03395	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C7M71_RS03400	COG1793	dna ligase
C7M71_RS03400	COG3285	dna ligase
C7M71_RS03455	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS03460	COG2894	cell division
C7M71_RS03490	COG0633	Ferredoxin
C7M71_RS03490	COG3217	Mosc domain protein beta barrel domain protein
C7M71_RS03505	COG1349	DNA-binding transcription factor activity
C7M71_RS03515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7M71_RS03530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7M71_RS03535	COG0254	rRNA binding
C7M71_RS03565	COG0738	Major facilitator superfamily
C7M71_RS03570	COG0110	maltose O-acetyltransferase activity
C7M71_RS03575	COG1024	Enoyl-CoA hydratase
C7M71_RS03595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7M71_RS03630	COG1660	Displays ATPase and GTPase activities
C7M71_RS03635	COG1940	carbohydrate kinase activity
C7M71_RS03640	COG1609	Transcriptional regulator
C7M71_RS03645	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS03650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C7M71_RS03680	COG4221	oxidoreductase activity
C7M71_RS03690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M71_RS03695	COG0765	amino acid transport
C7M71_RS03705	COG0672	)-iron permease
C7M71_RS03710	COG2837	iron assimilation
C7M71_RS03790	COG0366	Alpha amylase catalytic
C7M71_RS03795	COG3833	ABC-type maltose transport systems, permease component
C7M71_RS03800	COG1175	transmembrane transport
C7M71_RS03830	COG0366	Alpha amylase catalytic
C7M71_RS03835	COG0395	ABC-type sugar transport system, permease component
C7M71_RS03840	COG1175	transmembrane transport
C7M71_RS03875	COG0247	lactate metabolic process
C7M71_RS03875	COG0277	FAD linked oxidase domain protein
C7M71_RS03900	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C7M71_RS03905	COG0121	glutamine amidotransferase
C7M71_RS03910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7M71_RS03915	COG0436	Aminotransferase
C7M71_RS03925	COG3386	PFAM SMP-30 Gluconolaconase
C7M71_RS03935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7M71_RS03965	COG1609	Transcriptional regulator
C7M71_RS03990	COG0494	nUDIX hydrolase
C7M71_RS03995	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C7M71_RS04020	COG1132	(ABC) transporter
C7M71_RS04025	COG1132	(ABC) transporter
C7M71_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS04070	COG0671	phosphoesterase, PA-phosphatase related
C7M71_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS04125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C7M71_RS04150	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C7M71_RS04160	COG1562	ergosterol biosynthetic process
C7M71_RS04165	COG1134	teichoic acid transport
C7M71_RS04190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7M71_RS04200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C7M71_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS04265	COG0495	leucyl-tRNA aminoacylation
C7M71_RS04315	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7M71_RS04320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7M71_RS04330	COG1116	anion transmembrane transporter activity
C7M71_RS04335	COG0640	Transcriptional regulator
C7M71_RS04350	COG1940	carbohydrate kinase activity
C7M71_RS04355	COG1175	transmembrane transport
C7M71_RS04360	COG0395	ABC-type sugar transport system, permease component
C7M71_RS04370	COG3345	alpha-galactosidase
C7M71_RS04380	COG2084	Dehydrogenase
C7M71_RS04390	COG0006	proline dipeptidase activity
C7M71_RS04395	COG3958	Transketolase
C7M71_RS04400	COG3959	Transketolase, thiamine diphosphate binding domain
C7M71_RS04415	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS04440	COG1218	3'(2'),5'-bisphosphate nucleotidase
C7M71_RS04455	COG0477	Major facilitator Superfamily
C7M71_RS04460	COG1335	isochorismatase
C7M71_RS04480	COG1414	Transcriptional regulator
C7M71_RS04530	COG0671	phosphoesterase, PA-phosphatase related
C7M71_RS04555	COG0395	ABC-type sugar transport system, permease component
C7M71_RS04560	COG1175	transmembrane transport
C7M71_RS04580	COG0366	Alpha amylase catalytic
C7M71_RS04585	COG0076	glutamate decarboxylase activity
C7M71_RS04600	COG0444	Belongs to the ABC transporter superfamily
C7M71_RS04605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7M71_RS04610	COG0601	transmembrane transport
C7M71_RS04620	COG4166	transmembrane transport
C7M71_RS04625	COG1609	Transcriptional regulator
C7M71_RS04675	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C7M71_RS04715	COG0697	spore germination
C7M71_RS04720	COG0823	Involved in the tonB-independent uptake of proteins
C7M71_RS04720	COG1506	peptidase
C7M71_RS04745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7M71_RS04755	COG1946	Acyl-CoA thioesterase
C7M71_RS04770	COG1309	transcriptional regulator
C7M71_RS04775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7M71_RS04785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7M71_RS04790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7M71_RS04820	COG1929	Belongs to the glycerate kinase type-1 family
C7M71_RS04830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7M71_RS04835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7M71_RS04850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C7M71_RS04850	COG5297	Belongs to the glycosyl hydrolase family 6
C7M71_RS04870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7M71_RS04875	COG1609	Transcriptional regulator
C7M71_RS04880	COG1957	nucleoside hydrolase
C7M71_RS04910	COG3345	alpha-galactosidase
C7M71_RS04915	COG4608	Belongs to the ABC transporter superfamily
C7M71_RS04920	COG0444	Belongs to the ABC transporter superfamily
C7M71_RS04925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7M71_RS04935	COG0747	negative chemotaxis
C7M71_RS04940	COG1609	Transcriptional regulator
C7M71_RS04950	COG3458	cephalosporin-C deacetylase activity
C7M71_RS04960	COG0405	Gamma-glutamyltransferase
C7M71_RS04975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7M71_RS04980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7M71_RS04985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7M71_RS05035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M71_RS05040	COG1940	carbohydrate kinase activity
C7M71_RS05070	COG3835	regulator
C7M71_RS05085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7M71_RS05095	COG4948	Mandelate Racemase Muconate Lactonizing
C7M71_RS05110	COG1414	Transcriptional regulator
C7M71_RS05135	COG2226	methyltransferase
C7M71_RS05170	COG0667	Aldo Keto reductase
C7M71_RS05175	COG2353	YceI-like domain
C7M71_RS05210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7M71_RS05230	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS05255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7M71_RS05300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7M71_RS05335	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C7M71_RS05370	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C7M71_RS05375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS05420	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS05435	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C7M71_RS05445	COG3384	dioxygenase
C7M71_RS05500	COG0831	urea catabolic process
C7M71_RS05500	COG0832	Belongs to the urease beta subunit family
C7M71_RS05505	COG0804	urea catabolic process
C7M71_RS05510	COG2957	Belongs to the agmatine deiminase family
C7M71_RS05520	COG1309	transcriptional regulator
C7M71_RS05550	COG2814	Major facilitator Superfamily
C7M71_RS05560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7M71_RS05580	COG1162	GTPase activity
C7M71_RS05595	COG0175	sulfate reduction
C7M71_RS05600	COG0529	Catalyzes the synthesis of activated sulfate
C7M71_RS05625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C7M71_RS05630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C7M71_RS05640	COG1309	transcriptional regulator
C7M71_RS05655	COG1278	Cold shock
C7M71_RS05665	COG2409	Drug exporters of the RND superfamily
C7M71_RS05710	COG0237	dephospho-CoA kinase activity
C7M71_RS05715	COG2409	Drug exporters of the RND superfamily
C7M71_RS05725	COG2226	methyltransferase
C7M71_RS05730	COG1643	Atp-dependent helicase
C7M71_RS05740	COG2050	protein possibly involved in aromatic compounds catabolism
C7M71_RS05800	COG0737	Belongs to the 5'-nucleotidase family
C7M71_RS05810	COG0067	glutamate synthase
C7M71_RS05810	COG0070	glutamate synthase
C7M71_RS05810	COG0069	glutamate synthase activity
C7M71_RS05820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7M71_RS05840	COG0159	tryptophan synthase activity
C7M71_RS05845	COG0133	tryptophan synthase activity
C7M71_RS05855	COG0134	indole-3-glycerol-phosphate synthase activity
C7M71_RS05875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7M71_RS05880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C7M71_RS05905	COG0107	imidazoleglycerol-phosphate synthase activity
C7M71_RS05910	COG0251	oxidation-reduction process
C7M71_RS05915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7M71_RS05920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C7M71_RS05925	COG0131	Imidazoleglycerol-phosphate dehydratase
C7M71_RS05930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7M71_RS05935	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7M71_RS05955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C7M71_RS05960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7M71_RS05975	COG1131	(ABC) transporter
C7M71_RS05990	COG0587	DNA-directed DNA polymerase activity
C7M71_RS06045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C7M71_RS06055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C7M71_RS06060	COG3599	regulation of cell shape
C7M71_RS06070	COG1799	cell septum assembly
C7M71_RS06085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C7M71_RS06090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C7M71_RS06095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7M71_RS06105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7M71_RS06110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7M71_RS06120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7M71_RS06125	COG0768	penicillin binding
C7M71_RS06135	COG0275	rRNA processing
C7M71_RS06150	COG0714	Associated with various cellular activities
C7M71_RS06170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7M71_RS06175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C7M71_RS06195	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C7M71_RS06205	COG1309	transcriptional regulator
C7M71_RS06225	COG1733	regulation of RNA biosynthetic process
C7M71_RS06230	COG0778	Nitroreductase
C7M71_RS06275	COG0352	thiamine-phosphate diphosphorylase activity
C7M71_RS06295	COG1175	transmembrane transport
C7M71_RS06300	COG0395	ABC-type sugar transport system, permease component
C7M71_RS06305	COG2723	6-phospho-beta-galactosidase activity
C7M71_RS06310	COG2022	thiamine diphosphate biosynthetic process
C7M71_RS06310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7M71_RS06320	COG2022	thiamine diphosphate biosynthetic process
C7M71_RS06335	COG2815	serine threonine protein kinase
C7M71_RS06335	COG0515	serine threonine protein kinase
C7M71_RS06355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C7M71_RS06360	COG2193	ferroxidase activity
C7M71_RS06365	COG0243	molybdopterin cofactor binding
C7M71_RS06370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C7M71_RS06380	COG3191	aminopeptidase activity
C7M71_RS06385	COG0205	6-phosphofructokinase activity
C7M71_RS06390	COG2197	response regulator
C7M71_RS06420	COG1940	carbohydrate kinase activity
C7M71_RS06430	COG0003	Pfam Anion-transporting ATPase
C7M71_RS06460	COG0501	Belongs to the peptidase M48B family
C7M71_RS06510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7M71_RS06515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7M71_RS06525	COG1845	cytochrome c oxidase, subunit III
C7M71_RS06530	COG2010	Cytochrome c
C7M71_RS06535	COG0723	plastoquinol--plastocyanin reductase activity
C7M71_RS06540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C7M71_RS06555	COG1376	ErfK ybiS ycfS ynhG family protein
C7M71_RS06565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C7M71_RS06570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C7M71_RS06575	COG1104	cysteine desulfurase activity
C7M71_RS06580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7M71_RS06600	COG0076	glutamate decarboxylase activity
C7M71_RS06610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C7M71_RS06630	COG2226	methyltransferase
C7M71_RS06635	COG0667	Aldo Keto reductase
C7M71_RS06650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C7M71_RS06655	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C7M71_RS06660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7M71_RS06665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7M71_RS06670	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7M71_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS06710	COG0321	lipoyl(octanoyl) transferase activity
C7M71_RS06715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C7M71_RS06755	COG0784	Response regulator, receiver
C7M71_RS06765	COG4251	negative regulation of phosphorylation
C7M71_RS06780	COG0673	inositol 2-dehydrogenase activity
C7M71_RS06825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C7M71_RS06830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS06840	COG0431	NADPH-dependent FMN reductase
C7M71_RS06855	COG0583	DNA-binding transcription factor activity
C7M71_RS06870	COG2814	Major facilitator Superfamily
C7M71_RS06885	COG1252	NADH dehydrogenase
C7M71_RS06890	COG1595	DNA-templated transcription, initiation
C7M71_RS06925	COG2188	Transcriptional regulator
C7M71_RS06940	COG4974	Belongs to the 'phage' integrase family
C7M71_RS06980	COG3509	depolymerase
C7M71_RS06995	COG0174	glutamine synthetase
C7M71_RS07005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7M71_RS07005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7M71_RS07015	COG1309	transcriptional regulator
C7M71_RS07020	COG0477	Major facilitator Superfamily
C7M71_RS07025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C7M71_RS07030	COG5297	Belongs to the glycosyl hydrolase family 6
C7M71_RS07055	COG1994	Peptidase M50
C7M71_RS07105	COG1191	sigma factor activity
C7M71_RS07165	COG0375	protein maturation
C7M71_RS07175	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C7M71_RS07180	COG0298	carbon dioxide binding
C7M71_RS07190	COG0309	Hydrogenase expression formation protein (HypE)
C7M71_RS07235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7M71_RS07235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7M71_RS07240	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7M71_RS07245	COG0022	dehydrogenase e1 component
C7M71_RS07260	COG2050	protein possibly involved in aromatic compounds catabolism
C7M71_RS07270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7M71_RS07280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7M71_RS07285	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7M71_RS07335	COG0477	Major facilitator Superfamily
C7M71_RS07340	COG1064	alcohol dehydrogenase
C7M71_RS07345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M71_RS07350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M71_RS07365	COG1024	Enoyl-CoA hydratase
C7M71_RS07380	COG2197	response regulator
C7M71_RS07390	COG0183	Belongs to the thiolase family
C7M71_RS07440	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS07475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7M71_RS07480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7M71_RS07485	COG1418	mRNA catabolic process
C7M71_RS07530	COG3540	Alkaline phosphatase
C7M71_RS07575	COG3022	response to hydroperoxide
C7M71_RS07590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C7M71_RS07605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7M71_RS07610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7M71_RS07620	COG1506	peptidase
C7M71_RS07650	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7M71_RS07665	COG2226	methyltransferase
C7M71_RS07670	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS07675	COG1309	transcriptional regulator
C7M71_RS07695	COG3845	ABC transporter
C7M71_RS07705	COG4213	ABC transporter substrate-binding protein
C7M71_RS07715	COG4214	carbohydrate transport
C7M71_RS07775	COG5001	Diguanylate cyclase
C7M71_RS07795	COG1077	Cell shape determining protein MreB Mrl
C7M71_RS07800	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C7M71_RS07815	COG2890	protein-(glutamine-N5) methyltransferase activity
C7M71_RS07855	COG0437	4 iron, 4 sulfur cluster binding
C7M71_RS07860	COG0243	molybdopterin cofactor binding
C7M71_RS07860	COG3383	formate dehydrogenase (NAD+) activity
C7M71_RS07865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C7M71_RS07920	COG2186	Transcriptional regulator
C7M71_RS07925	COG0247	lactate metabolic process
C7M71_RS07930	COG1139	Iron-sulfur cluster binding protein
C7M71_RS07935	COG1556	Lactate utilization protein
C7M71_RS07945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7M71_RS07950	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7M71_RS07960	COG1129	ABC transporter
C7M71_RS07965	COG1869	D-ribose catabolic process
C7M71_RS07970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7M71_RS07975	COG2188	Transcriptional regulator
C7M71_RS07990	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M71_RS07995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M71_RS08015	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7M71_RS08025	COG3842	ATPase activity
C7M71_RS08030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7M71_RS08085	COG1674	ftsk spoiiie
C7M71_RS08125	COG0183	Belongs to the thiolase family
C7M71_RS08135	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7M71_RS08140	COG3396	Phenylacetate-CoA oxygenase
C7M71_RS08145	COG3460	Phenylacetate-CoA oxygenase
C7M71_RS08150	COG3396	Phenylacetate-CoA oxygenase
C7M71_RS08155	COG2151	metal-sulfur cluster biosynthetic enzyme
C7M71_RS08160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7M71_RS08165	COG0745	RESPONSE REGULATOR receiver
C7M71_RS08170	COG2205	protein histidine kinase activity
C7M71_RS08240	COG3409	Peptidoglycan-binding domain 1 protein
C7M71_RS08245	COG1940	carbohydrate kinase activity
C7M71_RS08280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C7M71_RS08285	COG0477	Major facilitator Superfamily
C7M71_RS08290	COG1309	transcriptional regulator
C7M71_RS08295	COG4585	Histidine kinase
C7M71_RS08300	COG2197	response regulator
C7M71_RS08325	COG0667	Aldo Keto reductase
C7M71_RS08330	COG0789	Transcriptional regulator
C7M71_RS08340	COG1741	Belongs to the pirin family
C7M71_RS08355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M71_RS08360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7M71_RS08365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7M71_RS08390	COG2130	NADP-dependent
C7M71_RS08425	COG1070	Carbohydrate kinase
C7M71_RS08435	COG0358	DNA primase activity
C7M71_RS08445	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C7M71_RS08455	COG0019	diaminopimelate decarboxylase activity
C7M71_RS08470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7M71_RS08500	COG1132	(ABC) transporter
C7M71_RS08535	COG0531	amino acid
C7M71_RS08540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7M71_RS08555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7M71_RS08555	COG0574	Belongs to the PEP-utilizing enzyme family
C7M71_RS08575	COG0423	glycine-tRNA ligase activity
C7M71_RS08585	COG1121	(ABC) transporter
C7M71_RS08590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7M71_RS08600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7M71_RS08605	COG1381	Involved in DNA repair and RecF pathway recombination
C7M71_RS08615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7M71_RS08630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7M71_RS08645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7M71_RS08655	COG1234	tRNA 3'-trailer cleavage
C7M71_RS08660	COG0537	adenosine 5'-monophosphoramidase activity
C7M71_RS08675	COG0484	heat shock protein binding
C7M71_RS08680	COG1420	regulation of RNA biosynthetic process
C7M71_RS08685	COG0501	Belongs to the peptidase M48B family
C7M71_RS08720	COG0481	GTPase activity
C7M71_RS08725	COG0268	Binds directly to 16S ribosomal RNA
C7M71_RS08760	COG1555	photosystem II stabilization
C7M71_RS08760	COG1596	polysaccharide export
C7M71_RS08765	COG1307	EDD domain protein, DegV family
C7M71_RS08775	COG0495	leucyl-tRNA aminoacylation
C7M71_RS08800	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C7M71_RS08810	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS08845	COG0588	phosphoglycerate mutase activity
C7M71_RS08850	COG0799	negative regulation of ribosome biogenesis
C7M71_RS08860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7M71_RS08865	COG0501	Belongs to the peptidase M48B family
C7M71_RS08880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7M71_RS08890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C7M71_RS08895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7M71_RS08900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7M71_RS08905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7M71_RS08910	COG1530	ribonuclease E activity
C7M71_RS08940	COG0772	Belongs to the SEDS family
C7M71_RS08945	COG0768	penicillin binding
C7M71_RS08960	COG1077	Cell shape determining protein MreB Mrl
C7M71_RS08965	COG0105	UTP biosynthetic process
C7M71_RS08975	COG0285	dihydrofolate synthase activity
C7M71_RS09010	COG0525	valine-tRNA ligase activity
C7M71_RS09020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7M71_RS09025	COG0740	serine-type endopeptidase activity
C7M71_RS09030	COG0740	serine-type endopeptidase activity
C7M71_RS09035	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7M71_RS09065	COG4552	Acetyltransferase involved in intracellular survival and related
C7M71_RS09085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C7M71_RS09105	COG0791	NLP P60 protein
C7M71_RS09105	COG0741	lytic transglycosylase activity
C7M71_RS09155	COG1609	Transcriptional regulator
C7M71_RS09165	COG1175	transmembrane transport
C7M71_RS09175	COG1472	Belongs to the glycosyl hydrolase 3 family
C7M71_RS09185	COG0235	Class ii aldolase
C7M71_RS09195	COG1522	sequence-specific DNA binding
C7M71_RS09205	COG0477	Major facilitator Superfamily
C7M71_RS09215	COG0252	asparaginase activity
C7M71_RS09240	COG0668	transmembrane transport
C7M71_RS09255	COG1175	transmembrane transport
C7M71_RS09260	COG0395	ABC-type sugar transport system, permease component
C7M71_RS09265	COG1486	melibiose metabolic process
C7M71_RS09315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7M71_RS09320	COG1131	(ABC) transporter
C7M71_RS09375	COG0339	signal peptide processing
C7M71_RS09420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7M71_RS09425	COG0386	Belongs to the glutathione peroxidase family
C7M71_RS09465	COG1739	Uncharacterized protein family UPF0029
C7M71_RS09470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7M71_RS09470	COG0515	serine threonine protein kinase
C7M71_RS09525	COG2233	PERMEase
C7M71_RS09535	COG2304	oxidoreductase activity
C7M71_RS09550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7M71_RS09550	COG0515	serine threonine protein kinase
C7M71_RS09570	COG3467	pyridoxamine 5'-phosphate
C7M71_RS09590	COG1309	transcriptional regulator
C7M71_RS09595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7M71_RS09610	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS09635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C7M71_RS09670	COG0395	ABC-type sugar transport system, permease component
C7M71_RS09695	COG0406	alpha-ribazole phosphatase activity
C7M71_RS09760	COG1605	Chorismate mutase
C7M71_RS09760	COG0287	Prephenate dehydrogenase
C7M71_RS09800	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS09805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS09810	COG2814	Major facilitator Superfamily
C7M71_RS09830	COG1231	oxidoreductase activity
C7M71_RS09840	COG0681	Belongs to the peptidase S26 family
C7M71_RS09855	COG0596	Alpha beta hydrolase
C7M71_RS09860	COG0667	Aldo Keto reductase
C7M71_RS09885	COG2095	MarC family integral membrane protein
C7M71_RS09895	COG0697	spore germination
C7M71_RS09915	COG2264	protein methyltransferase activity
C7M71_RS09930	COG0559	Belongs to the binding-protein-dependent transport system permease family
C7M71_RS09960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7M71_RS09965	COG2070	2-Nitropropane dioxygenase
C7M71_RS09975	COG0673	inositol 2-dehydrogenase activity
C7M71_RS09980	COG4585	Histidine kinase
C7M71_RS09990	COG0706	membrane insertase activity
C7M71_RS09995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7M71_RS10000	COG2733	membrane
C7M71_RS10040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7M71_RS10045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C7M71_RS10065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C7M71_RS10075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C7M71_RS10080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7M71_RS10085	COG1263	PTS System
C7M71_RS10090	COG1234	tRNA 3'-trailer cleavage
C7M71_RS10110	COG1113	amino acid transport
C7M71_RS10120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C7M71_RS10130	COG1335	isochorismatase
C7M71_RS10150	COG1404	Belongs to the peptidase S8 family
C7M71_RS10165	COG1515	deoxyribonuclease V activity
C7M71_RS10205	COG0745	RESPONSE REGULATOR receiver
C7M71_RS10215	COG1285	pathogenesis
C7M71_RS10220	COG0277	FAD linked oxidase domain protein
C7M71_RS10225	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C7M71_RS10235	COG3480	Lon protease (S16) C-terminal proteolytic domain
C7M71_RS10245	COG2205	protein histidine kinase activity
C7M71_RS10250	COG0745	RESPONSE REGULATOR receiver
C7M71_RS10255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7M71_RS10260	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7M71_RS10265	COG1061	Type III restriction enzyme res subunit
C7M71_RS10275	COG2267	carboxylic ester hydrolase activity
C7M71_RS10285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7M71_RS10300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C7M71_RS10310	COG1678	Uncharacterized ACR, COG1678
C7M71_RS10315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7M71_RS10325	COG0776	regulation of translation
C7M71_RS10335	COG1278	Cold shock
C7M71_RS10340	COG3973	AAA domain
C7M71_RS10350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7M71_RS10355	COG0793	Belongs to the peptidase S41A family
C7M71_RS10360	COG2177	Part of the ABC transporter FtsEX involved in
C7M71_RS10365	COG2884	Cell division ATP-binding protein ftsE
C7M71_RS10375	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C7M71_RS10385	COG0515	serine threonine protein kinase
C7M71_RS10390	COG1674	ftsk spoiiie
C7M71_RS10395	COG1653	transport
C7M71_RS10400	COG1175	transmembrane transport
C7M71_RS10405	COG0395	ABC-type sugar transport system, permease component
C7M71_RS10410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C7M71_RS10440	COG0653	protein targeting
C7M71_RS10450	COG3214	Protein conserved in bacteria
C7M71_RS10455	COG2197	response regulator
C7M71_RS10460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C7M71_RS10470	COG0823	Involved in the tonB-independent uptake of proteins
C7M71_RS10475	COG5000	phosphorelay sensor kinase activity
C7M71_RS10475	COG5002	protein histidine kinase activity
C7M71_RS10480	COG0745	RESPONSE REGULATOR receiver
C7M71_RS10485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C7M71_RS10505	COG0714	Associated with various cellular activities
C7M71_RS10555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C7M71_RS10565	COG1482	cell wall glycoprotein biosynthetic process
C7M71_RS10580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7M71_RS10635	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C7M71_RS10640	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C7M71_RS10640	COG0778	Nitroreductase
C7M71_RS10660	COG1316	TRANSCRIPTIONal
C7M71_RS10670	COG1316	TRANSCRIPTIONal
C7M71_RS10695	COG1136	(ABC) transporter
C7M71_RS10700	COG1316	TRANSCRIPTIONal
C7M71_RS10715	COG0259	pyridoxamine-phosphate oxidase activity
C7M71_RS10725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C7M71_RS10730	COG1832	CoA-binding protein
C7M71_RS10745	COG1959	2 iron, 2 sulfur cluster binding
C7M71_RS10750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C7M71_RS10750	COG1017	nitric oxide dioxygenase activity
C7M71_RS10760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C7M71_RS10775	COG2205	protein histidine kinase activity
C7M71_RS10780	COG0745	RESPONSE REGULATOR receiver
C7M71_RS10785	COG3104	oligopeptide transport
C7M71_RS10800	COG1191	sigma factor activity
C7M71_RS10805	COG1228	amidohydrolase
C7M71_RS10820	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C7M71_RS10830	COG1473	amidohydrolase
C7M71_RS10860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7M71_RS10875	COG2986	histidine ammonia-lyase
C7M71_RS10880	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C7M71_RS10890	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C7M71_RS10900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7M71_RS10920	COG0424	maF-like protein
C7M71_RS10925	COG4770	biotin carboxylase activity
C7M71_RS10990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7M71_RS11005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7M71_RS11010	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS11015	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS11020	COG3237	CsbD-like
C7M71_RS11075	COG1595	DNA-templated transcription, initiation
C7M71_RS11080	COG0745	RESPONSE REGULATOR receiver
C7M71_RS11085	COG2205	protein histidine kinase activity
C7M71_RS11115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7M71_RS11125	COG0583	DNA-binding transcription factor activity
C7M71_RS11130	COG2814	Major facilitator Superfamily
C7M71_RS11135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C7M71_RS11135	COG5297	Belongs to the glycosyl hydrolase family 6
C7M71_RS11175	COG1473	amidohydrolase
C7M71_RS11175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C7M71_RS11185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7M71_RS11185	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7M71_RS11200	COG2009	succinate dehydrogenase
C7M71_RS11235	COG1686	Belongs to the peptidase S11 family
C7M71_RS11245	COG1216	Glycosyl transferase, family 2
C7M71_RS11255	COG0180	Tryptophanyl-tRNA synthetase
C7M71_RS11270	COG1253	flavin adenine dinucleotide binding
C7M71_RS11325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7M71_RS11330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7M71_RS11335	COG0754	glutathionylspermidine amidase activity
C7M71_RS11345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C7M71_RS11350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7M71_RS11355	COG0039	L-malate dehydrogenase activity
C7M71_RS11370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7M71_RS11390	COG1714	RDD family
C7M71_RS11395	COG0138	bifunctional purine biosynthesis protein purh
C7M71_RS11420	COG0045	succinate-CoA ligase (ADP-forming) activity
C7M71_RS11430	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C7M71_RS11440	COG0714	Associated with various cellular activities
C7M71_RS11455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7M71_RS11470	COG3541	Predicted nucleotidyltransferase
C7M71_RS11490	COG2197	response regulator
C7M71_RS11515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7M71_RS11515	COG0519	Catalyzes the synthesis of GMP from XMP
C7M71_RS11525	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS11530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7M71_RS11535	COG2815	serine threonine protein kinase
C7M71_RS11535	COG0515	serine threonine protein kinase
C7M71_RS11545	COG2815	serine threonine protein kinase
C7M71_RS11545	COG0515	serine threonine protein kinase
C7M71_RS11555	COG0516	GMP reductase activity
C7M71_RS11575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C7M71_RS11580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7M71_RS11590	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS11605	COG1595	DNA-templated transcription, initiation
C7M71_RS11610	COG2197	response regulator
C7M71_RS11620	COG0583	DNA-binding transcription factor activity
C7M71_RS11630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C7M71_RS11645	COG0726	polysaccharide deacetylase
C7M71_RS11655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7M71_RS11680	COG0802	atpase or kinase
C7M71_RS11690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7M71_RS11705	COG0736	holo-[acyl-carrier-protein] synthase activity
C7M71_RS11710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7M71_RS11715	COG1072	(Pantothenic acid kinase))
C7M71_RS11725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7M71_RS11730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7M71_RS11735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7M71_RS11740	COG0488	(ABC) transporter
C7M71_RS11750	COG0101	tRNA pseudouridine synthase activity
C7M71_RS11755	COG0203	ribosomal protein L17
C7M71_RS11760	COG0202	RNA polymerase activity
C7M71_RS11765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7M71_RS11770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7M71_RS11775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7M71_RS11780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7M71_RS11790	COG0563	adenylate kinase activity
C7M71_RS11800	COG0200	Binds to the 23S rRNA
C7M71_RS11810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7M71_RS11815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7M71_RS11820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7M71_RS11825	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7M71_RS11830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7M71_RS11835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7M71_RS11840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7M71_RS11845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7M71_RS11850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7M71_RS11855	COG0255	Belongs to the universal ribosomal protein uL29 family
C7M71_RS11860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7M71_RS11865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7M71_RS11870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7M71_RS11875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7M71_RS11880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7M71_RS11890	COG0088	Forms part of the polypeptide exit tunnel
C7M71_RS11895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7M71_RS11900	COG0051	transcription antitermination factor activity, RNA binding
C7M71_RS11905	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS11910	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS11915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7M71_RS11920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7M71_RS11925	COG0049	tRNA binding
C7M71_RS11930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7M71_RS11940	COG1131	(ABC) transporter
C7M71_RS12065	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7M71_RS12070	COG0085	RNA polymerase activity
C7M71_RS12080	COG0222	ribosome binding
C7M71_RS12085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7M71_RS12100	COG0081	regulation of translation
C7M71_RS12105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7M71_RS12115	COG0250	Participates in transcription elongation, termination and antitermination
C7M71_RS12130	COG0436	Aminotransferase
C7M71_RS12135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C7M71_RS12140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7M71_RS12160	COG2030	dehydratase
C7M71_RS12165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7M71_RS12195	COG0531	amino acid
C7M71_RS12215	COG1666	GTP binding
C7M71_RS12225	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C7M71_RS12240	COG3304	Inner membrane component domain
C7M71_RS12245	COG0501	Belongs to the peptidase M48B family
C7M71_RS12250	COG1007	ATP synthesis coupled electron transport
C7M71_RS12265	COG0713	ATP synthesis coupled electron transport
C7M71_RS12275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7M71_RS12280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C7M71_RS12285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7M71_RS12290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7M71_RS12295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7M71_RS12310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7M71_RS12315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7M71_RS12325	COG1216	Glycosyl transferase, family 2
C7M71_RS12325	COG1442	glycosyl transferase family 8
C7M71_RS12340	COG2089	acid synthase
C7M71_RS12365	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS12370	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS12375	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS12380	COG3594	Acyltransferase
C7M71_RS12400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7M71_RS12405	COG1215	transferase activity, transferring glycosyl groups
C7M71_RS12420	COG1309	transcriptional regulator
C7M71_RS12425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M71_RS12460	COG1595	DNA-templated transcription, initiation
C7M71_RS12510	COG4821	SIS domain
C7M71_RS12525	COG0259	pyridoxamine-phosphate oxidase activity
C7M71_RS12535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C7M71_RS12560	COG2814	Major facilitator Superfamily
C7M71_RS12565	COG1846	Transcriptional regulator
C7M71_RS12620	COG2252	PERMEase
C7M71_RS12630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7M71_RS12675	COG0181	hydroxymethylbilane synthase activity
C7M71_RS12725	COG0387	Pfam Sodium calcium exchanger
C7M71_RS12735	COG2814	Major facilitator Superfamily
C7M71_RS12745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7M71_RS12750	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C7M71_RS12755	COG1278	Cold shock
C7M71_RS12780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M71_RS12785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M71_RS12790	COG1120	ATPase activity
C7M71_RS12820	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7M71_RS12825	COG1177	transmembrane transport
C7M71_RS12835	COG3842	ATPase activity
C7M71_RS12840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7M71_RS12845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C7M71_RS12850	COG3246	L-lysine catabolic process to acetate
C7M71_RS12880	COG1061	Type III restriction enzyme res subunit
C7M71_RS12895	COG3973	AAA domain
C7M71_RS12915	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS12920	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7M71_RS12925	COG0459	protein refolding
C7M71_RS12930	COG1278	Cold shock
C7M71_RS12940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7M71_RS12945	COG0463	Glycosyl transferase, family 2
C7M71_RS12990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7M71_RS13010	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C7M71_RS13050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7M71_RS13050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7M71_RS13090	COG3629	intracellular signal transduction
C7M71_RS13090	COG3903	Transcriptional regulator
C7M71_RS13105	COG3629	intracellular signal transduction
C7M71_RS13105	COG3903	Transcriptional regulator
C7M71_RS13195	COG3842	ATPase activity
C7M71_RS13205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7M71_RS13215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7M71_RS13220	COG0215	cysteine-tRNA ligase activity
C7M71_RS13230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C7M71_RS13235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7M71_RS13240	COG1329	Transcriptional regulator
C7M71_RS13255	COG0745	RESPONSE REGULATOR receiver
C7M71_RS13260	COG5002	protein histidine kinase activity
C7M71_RS13270	COG0588	phosphoglycerate mutase activity
C7M71_RS13285	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS13295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C7M71_RS13300	COG4565	transcriptional regulatory protein
C7M71_RS13320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7M71_RS13325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C7M71_RS13355	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS13355	COG0204	Acyl-transferase
C7M71_RS13365	COG2318	DinB family
C7M71_RS13390	COG4552	Acetyltransferase involved in intracellular survival and related
C7M71_RS13400	COG1490	D-aminoacyl-tRNA deacylase activity
C7M71_RS13450	COG3485	protocatechuate 3,4-dioxygenase
C7M71_RS13470	COG2897	thiosulfate sulfurtransferase activity
C7M71_RS13490	COG0745	RESPONSE REGULATOR receiver
C7M71_RS13495	COG1609	Transcriptional regulator
C7M71_RS13500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7M71_RS13505	COG0745	RESPONSE REGULATOR receiver
C7M71_RS13510	COG2205	protein histidine kinase activity
C7M71_RS13515	COG0737	Belongs to the 5'-nucleotidase family
C7M71_RS13525	COG0456	acetyltransferase
C7M71_RS13575	COG1937	Protein conserved in bacteria
C7M71_RS13595	COG0277	FAD linked oxidase domain protein
C7M71_RS13600	COG0671	phosphoesterase, PA-phosphatase related
C7M71_RS13605	COG0791	NLP P60 protein
C7M71_RS13735	COG0579	oxidoreductase
C7M71_RS13740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7M71_RS13755	COG0583	DNA-binding transcription factor activity
C7M71_RS13785	COG1396	sequence-specific DNA binding
C7M71_RS13805	COG0583	DNA-binding transcription factor activity
C7M71_RS13815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7M71_RS13855	COG2271	Major facilitator Superfamily
C7M71_RS13870	COG1942	4-Oxalocrotonate Tautomerase
C7M71_RS13880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7M71_RS13885	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C7M71_RS13915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C7M71_RS14025	COG0475	glutathione-regulated potassium exporter activity
C7M71_RS14030	COG0490	domain, Protein
C7M71_RS14035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7M71_RS14040	COG0726	polysaccharide deacetylase
C7M71_RS14055	COG3284	Transcriptional regulator
C7M71_RS14060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7M71_RS14090	COG2124	cytochrome p450
C7M71_RS14130	COG0513	Belongs to the DEAD box helicase family
C7M71_RS14165	COG1643	Atp-dependent helicase
C7M71_RS14195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C7M71_RS14215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7M71_RS14220	COG0047	phosphoribosylformylglycinamidine synthase activity
C7M71_RS14225	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7M71_RS14245	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C7M71_RS14265	COG0151	Belongs to the GarS family
C7M71_RS14295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7M71_RS14305	COG2124	cytochrome p450
C7M71_RS14315	COG3483	tryptophan 2,3-dioxygenase activity
C7M71_RS14325	COG0191	fructose-bisphosphate aldolase activity
C7M71_RS14330	COG0586	Pfam SNARE associated Golgi protein
C7M71_RS14335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7M71_RS14350	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C7M71_RS14365	COG0542	response to heat
C7M71_RS14385	COG0789	Transcriptional regulator
C7M71_RS14390	COG0484	heat shock protein binding
C7M71_RS14395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7M71_RS14400	COG0443	Heat shock 70 kDa protein
C7M71_RS14425	COG0717	Belongs to the dCTP deaminase family
C7M71_RS14520	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
C7M71_RS14540	COG1518	maintenance of DNA repeat elements
C7M71_RS14580	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS14640	COG0179	Fumarylacetoacetate (FAA) hydrolase
C7M71_RS14695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7M71_RS14725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7M71_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS14755	COG0655	NAD(P)H dehydrogenase (quinone) activity
C7M71_RS14760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7M71_RS14770	COG2264	protein methyltransferase activity
C7M71_RS14800	COG0477	Major facilitator Superfamily
C7M71_RS14885	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS14895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C7M71_RS14945	COG0419	ATPase involved in DNA repair
C7M71_RS15010	COG1741	Belongs to the pirin family
C7M71_RS15025	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS15035	COG1362	aminopeptidase activity
C7M71_RS15050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7M71_RS15060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7M71_RS15100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C7M71_RS15105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7M71_RS15160	COG2223	nitrite transmembrane transporter activity
C7M71_RS15175	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7M71_RS15180	COG0022	dehydrogenase e1 component
C7M71_RS15200	COG0515	serine threonine protein kinase
C7M71_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS15215	COG0604	alcohol dehydrogenase
C7M71_RS15215	COG3321	synthase
C7M71_RS15220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C7M71_RS15240	COG1902	pentaerythritol trinitrate reductase activity
C7M71_RS15255	COG0596	Alpha beta hydrolase
C7M71_RS15260	COG1309	transcriptional regulator
C7M71_RS15275	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C7M71_RS15345	COG0534	Mate efflux family protein
C7M71_RS15355	COG0359	binds to the 23S rRNA
C7M71_RS15360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7M71_RS15365	COG0629	single-stranded DNA binding
C7M71_RS15370	COG0360	Binds together with S18 to 16S ribosomal RNA
C7M71_RS15395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7M71_RS15415	COG0617	tRNA 3'-terminal CCA addition
C7M71_RS15430	COG2815	serine threonine protein kinase
C7M71_RS15430	COG0515	serine threonine protein kinase
C7M71_RS15450	COG3118	belongs to the thioredoxin family
C7M71_RS15470	COG0357	Ribosomal RNA small subunit methyltransferase G
C7M71_RS15480	COG0706	membrane insertase activity
C7M71_RS15485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C7M71_RS15490	COG0594	ribonuclease P activity
C7M71_RS15495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C7M71_RS15505	COG0592	DNA-directed DNA polymerase activity
C7M71_RS15510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C7M71_RS15515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7M71_RS15520	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C7M71_RS15530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7M71_RS15550	COG1408	metallophosphoesterase
C7M71_RS15555	COG0702	epimerase
C7M71_RS15575	COG0705	Rhomboid family
C7M71_RS15575	COG0457	Tetratricopeptide repeat
C7M71_RS15605	COG3764	Sortase (surface protein transpeptidase)
C7M71_RS15615	COG0515	serine threonine protein kinase
C7M71_RS15620	COG0768	penicillin binding
C7M71_RS15635	COG1716	ATPase activity
C7M71_RS15640	COG1716	ATPase activity
C7M71_RS15655	COG2197	response regulator
C7M71_RS15660	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C7M71_RS15660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7M71_RS15690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7M71_RS15730	COG1309	transcriptional regulator
C7M71_RS15735	COG1522	sequence-specific DNA binding
C7M71_RS15745	COG0022	dehydrogenase e1 component
C7M71_RS15750	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7M71_RS15775	COG1950	PFAM Membrane protein of
C7M71_RS15780	COG0662	Cupin 2, conserved barrel domain protein
C7M71_RS15785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C7M71_RS15795	COG2268	Band 7 protein
C7M71_RS15810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C7M71_RS15825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C7M71_RS15830	COG1609	Transcriptional regulator
C7M71_RS15835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7M71_RS15845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C7M71_RS15850	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7M71_RS15850	COG1136	(ABC) transporter
C7M71_RS15865	COG0745	RESPONSE REGULATOR receiver
C7M71_RS15870	COG2205	protein histidine kinase activity
C7M71_RS15875	COG1271	oxidase subunit
C7M71_RS15880	COG1294	oxidase, subunit
C7M71_RS15890	COG0561	phosphatase activity
C7M71_RS15940	COG1131	(ABC) transporter
C7M71_RS15950	COG1131	(ABC) transporter
C7M71_RS15965	COG2807	transmembrane transport
C7M71_RS15975	COG0561	phosphatase activity
C7M71_RS15980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7M71_RS15985	COG0077	Prephenate dehydratase
C7M71_RS15990	COG2837	iron assimilation
C7M71_RS15995	COG2372	response to copper ion
C7M71_RS16045	COG4585	Histidine kinase
C7M71_RS16050	COG2197	response regulator
C7M71_RS16060	COG0006	proline dipeptidase activity
C7M71_RS16075	COG0653	protein targeting
C7M71_RS16095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7M71_RS16130	COG0640	Transcriptional regulator
C7M71_RS16135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7M71_RS16140	COG1316	TRANSCRIPTIONal
C7M71_RS16150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7M71_RS16170	COG0477	Major facilitator Superfamily
C7M71_RS16190	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS16195	COG0745	RESPONSE REGULATOR receiver
C7M71_RS16240	COG0667	Aldo Keto reductase
C7M71_RS16250	COG2365	Tyrosine phosphatase family
C7M71_RS16255	COG1191	sigma factor activity
C7M71_RS16275	COG0590	tRNA wobble adenosine to inosine editing
C7M71_RS16290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7M71_RS16310	COG0592	DNA-directed DNA polymerase activity
C7M71_RS16335	COG1120	ATPase activity
C7M71_RS16340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M71_RS16345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7M71_RS16360	COG5398	heme oxygenase
C7M71_RS16510	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS16520	COG0583	DNA-binding transcription factor activity
C7M71_RS16560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7M71_RS16565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7M71_RS16585	COG1595	DNA-templated transcription, initiation
C7M71_RS16595	COG1566	PFAM secretion protein HlyD family protein
C7M71_RS16615	COG1408	metallophosphoesterase
C7M71_RS16630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7M71_RS16640	COG0003	Pfam Anion-transporting ATPase
C7M71_RS16665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7M71_RS16705	COG2267	carboxylic ester hydrolase activity
C7M71_RS16715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C7M71_RS16720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7M71_RS16780	COG1205	dead DEAH box helicase
C7M71_RS16780	COG1111	helicase
C7M71_RS16785	COG1366	Belongs to the anti-sigma-factor antagonist family
C7M71_RS16790	COG2172	sigma factor antagonist activity
C7M71_RS16795	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C7M71_RS16805	COG1131	(ABC) transporter
C7M71_RS16820	COG2890	protein-(glutamine-N5) methyltransferase activity
C7M71_RS16830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7M71_RS16830	COG1754	DNA topoisomerase type I activity
C7M71_RS16835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7M71_RS16895	COG0477	Major facilitator Superfamily
C7M71_RS16915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7M71_RS16920	COG2192	nodulation
C7M71_RS16930	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C7M71_RS16930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7M71_RS16935	COG0456	acetyltransferase
C7M71_RS16950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C7M71_RS16955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7M71_RS16965	COG1063	alcohol dehydrogenase
C7M71_RS16990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7M71_RS17020	COG0019	diaminopimelate decarboxylase activity
C7M71_RS17040	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS17080	COG3360	Dodecin
C7M71_RS17105	COG0326	Molecular chaperone. Has ATPase activity
C7M71_RS17115	COG0586	Pfam SNARE associated Golgi protein
C7M71_RS17140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C7M71_RS17145	COG2027	D-alanyl-D-alanine carboxypeptidase
C7M71_RS17155	COG0037	tRNA processing
C7M71_RS17170	COG0302	gtp cyclohydrolase
C7M71_RS17175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7M71_RS17175	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C7M71_RS17180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C7M71_RS17190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C7M71_RS17210	COG0649	NAD binding
C7M71_RS17225	COG2197	response regulator
C7M71_RS17240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C7M71_RS17245	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C7M71_RS17250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C7M71_RS17260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C7M71_RS17275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7M71_RS17290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C7M71_RS17315	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS17325	COG1309	transcriptional regulator
C7M71_RS17330	COG0477	Major facilitator Superfamily
C7M71_RS17350	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C7M71_RS17375	COG0248	Ppx GppA phosphatase
C7M71_RS17385	COG1082	Xylose isomerase domain protein TIM barrel
C7M71_RS17410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7M71_RS17415	COG1349	DNA-binding transcription factor activity
C7M71_RS17420	COG0129	dihydroxy-acid dehydratase activity
C7M71_RS17435	COG0842	Transport permease protein
C7M71_RS17435	COG1129	ABC transporter
C7M71_RS17450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7M71_RS17455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7M71_RS17470	COG0738	Major facilitator superfamily
C7M71_RS17475	COG0123	including yeast histone deacetylase and acetoin utilization protein
C7M71_RS17525	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7M71_RS17530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C7M71_RS17535	COG0181	hydroxymethylbilane synthase activity
C7M71_RS17540	COG1648	precorrin-2 dehydrogenase activity
C7M71_RS17540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7M71_RS17545	COG0113	porphobilinogen synthase activity
C7M71_RS17570	COG1742	UPF0060 membrane protein
C7M71_RS17595	COG2353	YceI-like domain
C7M71_RS17625	COG0105	UTP biosynthetic process
C7M71_RS17650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7M71_RS17655	COG0406	alpha-ribazole phosphatase activity
C7M71_RS17665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7M71_RS17670	COG0785	Cytochrome C biogenesis protein
C7M71_RS17675	COG1333	cytochrome c biogenesis protein
C7M71_RS17680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C7M71_RS17690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7M71_RS17715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7M71_RS17820	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C7M71_RS17825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C7M71_RS17840	COG0163	prenyltransferase activity
C7M71_RS17845	COG1522	sequence-specific DNA binding
C7M71_RS17850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7M71_RS17855	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C7M71_RS17870	COG1609	Transcriptional regulator
C7M71_RS17885	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C7M71_RS17895	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C7M71_RS17910	COG2226	methyltransferase
C7M71_RS17935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7M71_RS17940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7M71_RS17945	COG0649	NAD binding
C7M71_RS17955	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C7M71_RS17960	COG1034	ATP synthesis coupled electron transport
C7M71_RS17965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C7M71_RS17970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7M71_RS17980	COG0713	ATP synthesis coupled electron transport
C7M71_RS17985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C7M71_RS17995	COG1007	ATP synthesis coupled electron transport
C7M71_RS18000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C7M71_RS18020	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7M71_RS18025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7M71_RS18035	COG4733	cellulase activity
C7M71_RS18035	COG5297	Belongs to the glycosyl hydrolase family 6
C7M71_RS18040	COG1733	regulation of RNA biosynthetic process
C7M71_RS18045	COG0702	epimerase
C7M71_RS18075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C7M71_RS18100	COG1686	Belongs to the peptidase S11 family
C7M71_RS18155	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C7M71_RS18200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M71_RS18220	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS18230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7M71_RS18240	COG3328	transposase activity
C7M71_RS18265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7M71_RS18350	COG0523	cobalamin synthesis protein
C7M71_RS18355	COG0477	Major facilitator Superfamily
C7M71_RS18365	COG0277	FAD linked oxidase domain protein
C7M71_RS18380	COG1278	Cold shock
C7M71_RS18385	COG0513	Belongs to the DEAD box helicase family
C7M71_RS18400	COG1254	Belongs to the acylphosphatase family
C7M71_RS18405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7M71_RS18415	COG1764	response to oxidative stress
C7M71_RS18420	COG1846	Transcriptional regulator
C7M71_RS18425	COG0183	Belongs to the thiolase family
C7M71_RS18435	COG1309	transcriptional regulator
C7M71_RS18455	COG0235	Class ii aldolase
C7M71_RS18475	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C7M71_RS18495	COG3263	regulation of cellular component size
C7M71_RS18505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7M71_RS18515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7M71_RS18525	COG0315	cyclic pyranopterin monophosphate synthase activity
C7M71_RS18530	COG0521	Mo-molybdopterin cofactor biosynthetic process
C7M71_RS18535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7M71_RS18595	COG2304	oxidoreductase activity
C7M71_RS18620	COG0768	penicillin binding
C7M71_RS18630	COG4585	Histidine kinase
C7M71_RS18635	COG2197	response regulator
C7M71_RS18650	COG0768	penicillin binding
C7M71_RS18670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M71_RS18675	COG0084	hydrolase, TatD family'
C7M71_RS18680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7M71_RS18685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7M71_RS18690	COG0488	(ABC) transporter
C7M71_RS18740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7M71_RS18750	COG1086	Polysaccharide biosynthesis protein
C7M71_RS18755	COG1846	Transcriptional regulator
C7M71_RS18760	COG4106	trans-aconitate 2-methyltransferase activity
C7M71_RS18765	COG1309	transcriptional regulator
C7M71_RS18780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7M71_RS18785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7M71_RS18790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C7M71_RS18795	COG0193	aminoacyl-tRNA hydrolase activity
C7M71_RS18815	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C7M71_RS18820	COG4585	Histidine kinase
C7M71_RS18840	COG0673	inositol 2-dehydrogenase activity
C7M71_RS18855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C7M71_RS18890	COG3903	Transcriptional regulator
C7M71_RS18890	COG3629	intracellular signal transduction
C7M71_RS18930	COG1672	PFAM Archaeal ATPase
C7M71_RS18930	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C7M71_RS18935	COG1404	Belongs to the peptidase S8 family
C7M71_RS19010	COG2124	cytochrome p450
C7M71_RS19020	COG0148	phosphopyruvate hydratase activity
C7M71_RS19040	COG1252	NADH dehydrogenase
C7M71_RS19045	COG0577	efflux transmembrane transporter activity
C7M71_RS19095	COG0183	Belongs to the thiolase family
C7M71_RS19140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7M71_RS19155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7M71_RS19160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7M71_RS19170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C7M71_RS19180	COG1331	Highly conserved protein containing a thioredoxin domain
C7M71_RS19185	COG1309	transcriptional regulator
C7M71_RS19190	COG0477	Major facilitator Superfamily
C7M71_RS19200	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C7M71_RS19225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7M71_RS19245	COG0667	Aldo Keto reductase
C7M71_RS19250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7M71_RS19255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C7M71_RS19260	COG0741	lytic transglycosylase activity
C7M71_RS19270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C7M71_RS19275	COG0450	alkyl hydroperoxide reductase
C7M71_RS19295	COG2814	Major facilitator Superfamily
C7M71_RS19305	COG0114	fumarate hydratase activity
C7M71_RS19320	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C7M71_RS19320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C7M71_RS19345	COG0778	Nitroreductase
C7M71_RS19350	COG1722	exodeoxyribonuclease VII activity
C7M71_RS19360	COG1570	exodeoxyribonuclease VII activity
C7M71_RS19365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C7M71_RS19380	COG0012	GTP binding
C7M71_RS19425	COG0494	nUDIX hydrolase
C7M71_RS19475	COG0601	transmembrane transport
C7M71_RS19480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7M71_RS19490	COG4608	Belongs to the ABC transporter superfamily
C7M71_RS19495	COG4166	transmembrane transport
C7M71_RS19500	COG0601	transmembrane transport
C7M71_RS19515	COG4608	Belongs to the ABC transporter superfamily
C7M71_RS19525	COG4608	Belongs to the ABC transporter superfamily
C7M71_RS19530	COG0444	Belongs to the ABC transporter superfamily
C7M71_RS19535	COG0601	transmembrane transport
C7M71_RS19540	COG0747	negative chemotaxis
C7M71_RS19560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C7M71_RS19580	COG1131	(ABC) transporter
C7M71_RS19590	COG2197	response regulator
C7M71_RS19625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M71_RS19630	COG1611	Belongs to the LOG family
C7M71_RS19635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C7M71_RS19645	COG0519	Catalyzes the synthesis of GMP from XMP
C7M71_RS19650	COG1024	Enoyl-CoA hydratase
C7M71_RS19665	COG1595	DNA-templated transcription, initiation
C7M71_RS19675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7M71_RS19680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7M71_RS19690	COG4335	DNA alkylation repair
C7M71_RS19705	COG2239	Acts as a magnesium transporter
C7M71_RS19720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7M71_RS19745	COG2197	response regulator
C7M71_RS19775	COG2095	MarC family integral membrane protein
C7M71_RS19790	COG2814	Major facilitator Superfamily
C7M71_RS19830	COG0596	Alpha beta hydrolase
C7M71_RS19845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7M71_RS19905	COG0210	DNA helicase
C7M71_RS19925	COG1136	(ABC) transporter
C7M71_RS19925	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7M71_RS19935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M71_RS19940	COG2816	NAD+ diphosphatase activity
C7M71_RS19950	COG2188	Transcriptional regulator
C7M71_RS20020	COG3480	Lon protease (S16) C-terminal proteolytic domain
C7M71_RS20030	COG1615	UPF0182 protein
C7M71_RS20060	COG0753	catalase activity
C7M71_RS20070	COG0483	inositol monophosphate 1-phosphatase activity
C7M71_RS20090	COG1162	GTPase activity
C7M71_RS20095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C7M71_RS20105	COG2135	peptidase activity
C7M71_RS20115	COG1595	DNA-templated transcription, initiation
C7M71_RS20120	COG5662	AntiSigma factor
C7M71_RS20135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C7M71_RS20145	COG0242	peptide deformylase activity
C7M71_RS20150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7M71_RS20155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7M71_RS20155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7M71_RS20185	COG2188	Transcriptional regulator
C7M71_RS20190	COG2182	Extracellular solute-binding protein
C7M71_RS20195	COG1175	transmembrane transport
C7M71_RS20200	COG0395	ABC-type sugar transport system, permease component
C7M71_RS20205	COG1472	Belongs to the glycosyl hydrolase 3 family
C7M71_RS20210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7M71_RS20215	COG2855	membrane
C7M71_RS20275	COG1597	lipid kinase activity
C7M71_RS20290	COG2172	sigma factor antagonist activity
C7M71_RS20325	COG4106	trans-aconitate 2-methyltransferase activity
C7M71_RS20330	COG1126	abc transporter atp-binding protein
C7M71_RS20335	COG0765	amino acid transport
C7M71_RS20340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M71_RS20345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7M71_RS20355	COG0604	alcohol dehydrogenase
C7M71_RS20385	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7M71_RS20385	COG0567	Dehydrogenase, E1 component
C7M71_RS20390	COG2205	protein histidine kinase activity
C7M71_RS20395	COG0745	RESPONSE REGULATOR receiver
C7M71_RS20425	COG2304	oxidoreductase activity
C7M71_RS20485	COG0642	Histidine kinase
C7M71_RS20490	COG2018	Roadblock/LC7 domain
C7M71_RS20535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS20565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS20570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS20630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7M71_RS20650	COG0745	RESPONSE REGULATOR receiver
C7M71_RS20655	COG0018	arginyl-trna synthetase
C7M71_RS20660	COG0019	diaminopimelate decarboxylase activity
C7M71_RS20665	COG0460	homoserine dehydrogenase
C7M71_RS20670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7M71_RS20675	COG0083	homoserine kinase activity
C7M71_RS20695	COG0254	rRNA binding
C7M71_RS20700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7M71_RS20705	COG2890	protein-(glutamine-N5) methyltransferase activity
C7M71_RS20720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7M71_RS20725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7M71_RS20730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7M71_RS20745	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7M71_RS20750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7M71_RS20755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7M71_RS20760	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7M71_RS20765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7M71_RS20770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7M71_RS20775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7M71_RS20795	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7M71_RS20810	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C7M71_RS20865	COG0183	Belongs to the thiolase family
C7M71_RS20920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7M71_RS20920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7M71_RS20965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7M71_RS20970	COG0857	belongs to the CobB CobQ family
C7M71_RS20970	COG0280	phosphate acetyltransferase
C7M71_RS20995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C7M71_RS21000	COG3281	Trehalose synthase
C7M71_RS21010	COG0366	Alpha amylase catalytic
C7M71_RS21020	COG0058	SHG alpha-glucan phosphorylase activity
C7M71_RS21025	COG1132	(ABC) transporter
C7M71_RS21030	COG1132	(ABC) transporter
C7M71_RS21050	COG1376	ErfK ybiS ycfS ynhG family protein
C7M71_RS21105	COG1760	l-serine dehydratase
C7M71_RS21110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7M71_RS21115	COG0509	glycine decarboxylation via glycine cleavage system
C7M71_RS21120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C7M71_RS21150	COG4166	transmembrane transport
C7M71_RS21165	COG4608	Belongs to the ABC transporter superfamily
C7M71_RS21170	COG2860	membrane
C7M71_RS21185	COG0482	sulfurtransferase activity
C7M71_RS21205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7M71_RS21215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7M71_RS21220	COG0154	amidase activity
C7M71_RS21230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7M71_RS21240	COG2197	response regulator
C7M71_RS21250	COG5001	Diguanylate cyclase
C7M71_RS21260	COG0440	acetolactate synthase activity
C7M71_RS21265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C7M71_RS21270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7M71_RS21280	COG0473	3-isopropylmalate dehydrogenase activity
C7M71_RS21285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7M71_RS21290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7M71_RS21305	COG2018	Roadblock/LC7 domain
C7M71_RS21325	COG2018	Roadblock/LC7 domain
C7M71_RS21340	COG0179	Fumarylacetoacetate (FAA) hydrolase
C7M71_RS21345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7M71_RS21380	COG1414	Transcriptional regulator
C7M71_RS21385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7M71_RS21390	COG0066	3-isopropylmalate dehydratase activity
C7M71_RS21400	COG0776	regulation of translation
C7M71_RS21410	COG1920	GTP binding
C7M71_RS21420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7M71_RS21425	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7M71_RS21450	COG0351	phosphomethylpyrimidine kinase
C7M71_RS21460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7M71_RS21465	COG1461	Dihydroxyacetone kinase
C7M71_RS21470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7M71_RS21480	COG0742	ribosomal rna small subunit methyltransferase
C7M71_RS21485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7M71_RS21500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7M71_RS21505	COG0571	ribonuclease III activity
C7M71_RS21510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7M71_RS21520	COG1254	Belongs to the acylphosphatase family
C7M71_RS21550	COG3422	double-strand break repair
C7M71_RS21605	COG0442	prolyl-tRNA aminoacylation
C7M71_RS21615	COG0228	four-way junction DNA binding
C7M71_RS21620	COG1837	Belongs to the UPF0109 family
C7M71_RS21625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7M71_RS21630	COG0336	Belongs to the RNA methyltransferase TrmD family
C7M71_RS21635	COG0335	large ribosomal subunit rRNA binding
C7M71_RS21645	COG0681	Belongs to the peptidase S26 family
C7M71_RS21665	COG0792	nuclease activity
C7M71_RS21680	COG1191	sigma factor activity
C7M71_RS21695	COG0052	Belongs to the universal ribosomal protein uS2 family
C7M71_RS21700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7M71_RS21705	COG0528	UMP kinase activity
C7M71_RS21710	COG0233	cytoplasmic translational termination
C7M71_RS21715	COG0575	Belongs to the CDS family
C7M71_RS21720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C7M71_RS21730	COG1136	(ABC) transporter
C7M71_RS21735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C7M71_RS21745	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS21775	COG3842	ATPase activity
C7M71_RS21780	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7M71_RS21785	COG1177	transmembrane transport
C7M71_RS21790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7M71_RS21850	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS21860	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7M71_RS21880	COG0750	zinc metalloprotease
C7M71_RS21885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C7M71_RS21915	COG0779	Required for maturation of 30S ribosomal subunits
C7M71_RS21930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7M71_RS21940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7M71_RS21945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7M71_RS21950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7M71_RS21990	COG1404	Belongs to the peptidase S8 family
C7M71_RS22000	COG1674	ftsk spoiiie
C7M71_RS22005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C7M71_RS22020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7M71_RS22025	COG1185	polyribonucleotide nucleotidyltransferase activity
C7M71_RS22030	COG0612	Peptidase, M16
C7M71_RS22035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7M71_RS22050	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C7M71_RS22055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7M71_RS22060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C7M71_RS22090	COG1793	dna ligase
C7M71_RS22115	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS22140	COG0673	inositol 2-dehydrogenase activity
C7M71_RS22165	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C7M71_RS22180	COG2208	phosphoserine phosphatase activity
C7M71_RS22180	COG2770	Histidine kinase
C7M71_RS22185	COG3850	Histidine kinase
C7M71_RS22185	COG3437	response regulator, receiver
C7M71_RS22185	COG2205	protein histidine kinase activity
C7M71_RS22185	COG4999	Histidine kinase
C7M71_RS22195	COG1674	ftsk spoiiie
C7M71_RS22205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7M71_RS22215	COG1546	Belongs to the CinA family
C7M71_RS22215	COG1058	Belongs to the CinA family
C7M71_RS22220	COG1396	sequence-specific DNA binding
C7M71_RS22230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7M71_RS22240	COG1404	Belongs to the peptidase S8 family
C7M71_RS22290	COG2897	thiosulfate sulfurtransferase activity
C7M71_RS22305	COG0765	amino acid transport
C7M71_RS22310	COG0765	amino acid transport
C7M71_RS22320	COG1126	abc transporter atp-binding protein
C7M71_RS22325	COG0745	RESPONSE REGULATOR receiver
C7M71_RS22330	COG2205	protein histidine kinase activity
C7M71_RS22335	COG0515	serine threonine protein kinase
C7M71_RS22345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7M71_RS22365	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7M71_RS22375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7M71_RS22380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7M71_RS22385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7M71_RS22415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7M71_RS22420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7M71_RS22440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7M71_RS22485	COG2186	Transcriptional regulator
C7M71_RS22495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7M71_RS22510	COG0187	DNA topoisomerase II activity
C7M71_RS22520	COG4585	Histidine kinase
C7M71_RS22525	COG2197	response regulator
C7M71_RS22530	COG5297	Belongs to the glycosyl hydrolase family 6
C7M71_RS22540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7M71_RS22570	COG3265	gluconokinase activity
C7M71_RS22575	COG3842	ATPase activity
C7M71_RS22580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C7M71_RS22590	COG1177	transmembrane transport
C7M71_RS22655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7M71_RS22705	COG3485	protocatechuate 3,4-dioxygenase
C7M71_RS22725	COG2197	response regulator
C7M71_RS22730	COG4585	Histidine kinase
C7M71_RS22745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7M71_RS22750	COG0612	Peptidase, M16
C7M71_RS22780	COG1690	Belongs to the RtcB family
C7M71_RS22785	COG0494	nUDIX hydrolase
C7M71_RS22810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7M71_RS22815	COG1518	maintenance of DNA repeat elements
C7M71_RS22830	COG1857	crispr-associated protein
C7M71_RS22850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7M71_RS22870	COG1435	thymidine kinase activity
C7M71_RS22915	COG0745	RESPONSE REGULATOR receiver
C7M71_RS22920	COG2205	protein histidine kinase activity
C7M71_RS22950	COG0756	dUTP diphosphatase activity
C7M71_RS23000	COG0569	domain protein
C7M71_RS23005	COG0531	amino acid
C7M71_RS23010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7M71_RS23035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7M71_RS23045	COG1349	DNA-binding transcription factor activity
C7M71_RS23055	COG1175	transmembrane transport
C7M71_RS23060	COG0395	ABC-type sugar transport system, permease component
C7M71_RS23065	COG1063	alcohol dehydrogenase
C7M71_RS23080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7M71_RS23135	COG2171	N-acyltransferase activity
C7M71_RS23145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C7M71_RS23155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7M71_RS23170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C7M71_RS23180	COG1653	transport
C7M71_RS23185	COG1175	transmembrane transport
C7M71_RS23190	COG0395	ABC-type sugar transport system, permease component
C7M71_RS23200	COG1940	carbohydrate kinase activity
C7M71_RS23205	COG4213	ABC transporter substrate-binding protein
C7M71_RS23215	COG4214	carbohydrate transport
C7M71_RS23225	COG0531	amino acid
C7M71_RS23240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C7M71_RS23275	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7M71_RS23275	COG1024	Enoyl-CoA hydratase
C7M71_RS23280	COG0183	Belongs to the thiolase family
C7M71_RS23300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C7M71_RS23335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7M71_RS23340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7M71_RS23360	COG0556	nucleotide-excision repair
C7M71_RS23395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7M71_RS23410	COG0322	excinuclease ABC activity
C7M71_RS23415	COG1660	Displays ATPase and GTPase activities
C7M71_RS23425	COG1481	regulation of sporulation
C7M71_RS23430	COG3979	chitinase
C7M71_RS23435	COG3619	membrane
C7M71_RS23450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7M71_RS23455	COG0126	phosphoglycerate kinase activity
C7M71_RS23460	COG0149	triose-phosphate isomerase activity
C7M71_RS23465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7M71_RS23475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7M71_RS23480	COG0166	Belongs to the GPI family
C7M71_RS23485	COG0363	glucosamine-6-phosphate deaminase activity
C7M71_RS23500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7M71_RS23505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C7M71_RS23510	COG0109	protoheme IX farnesyltransferase activity
C7M71_RS23540	COG1131	(ABC) transporter
C7M71_RS23545	COG2746	aminoglycoside 3-N-acetyltransferase activity
C7M71_RS23560	COG0719	Fe-S assembly protein
C7M71_RS23570	COG0396	ATPase activity
C7M71_RS23575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7M71_RS23580	COG0822	iron-sulfur transferase activity
C7M71_RS23585	COG2151	metal-sulfur cluster biosynthetic enzyme
C7M71_RS23635	COG0582	viral genome integration into host DNA
C7M71_RS23675	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS23700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7M71_RS23705	COG1414	Transcriptional regulator
C7M71_RS23720	COG0586	Pfam SNARE associated Golgi protein
C7M71_RS23725	COG0671	phosphoesterase, PA-phosphatase related
C7M71_RS23735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7M71_RS23750	COG2076	Multidrug Resistance protein
C7M71_RS23760	COG3842	ATPase activity
C7M71_RS23770	COG3833	ABC-type maltose transport systems, permease component
C7M71_RS23785	COG0395	ABC-type sugar transport system, permease component
C7M71_RS23790	COG1175	transmembrane transport
C7M71_RS23830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7M71_RS23840	COG0477	Major facilitator Superfamily
C7M71_RS23845	COG2188	Transcriptional regulator
C7M71_RS23905	COG2890	protein-(glutamine-N5) methyltransferase activity
C7M71_RS23910	COG1797	cobyrinic acid a,c-diamide synthase activity
C7M71_RS23930	COG1492	cobalamin metabolic process
C7M71_RS23935	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C7M71_RS23955	COG4974	Belongs to the 'phage' integrase family
C7M71_RS23960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7M71_RS23980	COG0174	glutamine synthetase
C7M71_RS23990	COG0688	phosphatidylethanolamine metabolic process
C7M71_RS23995	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS24010	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7M71_RS24010	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7M71_RS24045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7M71_RS24080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7M71_RS24090	COG0728	peptidoglycan biosynthetic process
C7M71_RS24120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M71_RS24135	COG1619	proteins homologs of microcin C7 resistance protein MccF
C7M71_RS24145	COG0488	(ABC) transporter
C7M71_RS24155	COG1024	Enoyl-CoA hydratase
C7M71_RS24170	COG1199	ATP-dependent helicase activity
C7M71_RS24170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7M71_RS24180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C7M71_RS24185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C7M71_RS24255	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS24260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7M71_RS24270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C7M71_RS24275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C7M71_RS24280	COG3844	kynureninase activity
C7M71_RS24285	COG2186	Transcriptional regulator
C7M71_RS24290	COG2807	transmembrane transport
C7M71_RS24295	COG2062	phosphohistidine phosphatase, SixA
C7M71_RS24300	COG3830	Belongs to the UPF0237 family
C7M71_RS24300	COG0560	Phosphoserine phosphatase
C7M71_RS24310	COG1716	ATPase activity
C7M71_RS24310	COG1131	(ABC) transporter
C7M71_RS24310	COG0842	Transport permease protein
C7M71_RS24320	COG4585	Histidine kinase
C7M71_RS24325	COG2197	response regulator
C7M71_RS24340	COG1119	ATPase activity
C7M71_RS24360	COG2154	pterin-4-alpha-carbinolamine dehydratase
C7M71_RS24375	COG1881	PFAM PEBP family protein
C7M71_RS24385	COG2094	Belongs to the DNA glycosylase MPG family
C7M71_RS24390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7M71_RS24430	COG0647	UMP catabolic process
C7M71_RS24455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7M71_RS24465	COG0497	DNA recombination
C7M71_RS24475	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS24480	COG3387	PFAM Glycoside hydrolase 15-related
C7M71_RS24485	COG0504	CTP synthase activity
C7M71_RS24490	COG0494	nUDIX hydrolase
C7M71_RS24505	COG0686	Belongs to the AlaDH PNT family
C7M71_RS24520	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C7M71_RS24525	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7M71_RS24530	COG1187	pseudouridine synthase activity
C7M71_RS24540	COG4977	sequence-specific DNA binding
C7M71_RS24540	COG1917	Cupin 2, conserved barrel domain protein
C7M71_RS24595	COG3903	Transcriptional regulator
C7M71_RS24595	COG3629	intracellular signal transduction
C7M71_RS24605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7M71_RS24620	COG0445	tRNA wobble uridine modification
C7M71_RS24625	COG0475	glutathione-regulated potassium exporter activity
C7M71_RS24635	COG3321	synthase
C7M71_RS24635	COG0604	alcohol dehydrogenase
C7M71_RS24635	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS24650	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C7M71_RS24660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7M71_RS24680	COG2409	Drug exporters of the RND superfamily
C7M71_RS24695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C7M71_RS24695	COG0674	pyruvate-flavodoxin oxidoreductase activity
C7M71_RS24700	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7M71_RS24715	COG1397	ADP-ribosylglycohydrolase
C7M71_RS24725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7M71_RS24735	COG1160	GTP binding
C7M71_RS24750	COG1652	LysM domain
C7M71_RS24765	COG1946	Acyl-CoA thioesterase
C7M71_RS24775	COG0477	Major facilitator Superfamily
C7M71_RS24790	COG0720	synthase
C7M71_RS24850	COG0515	serine threonine protein kinase
C7M71_RS24850	COG2815	serine threonine protein kinase
C7M71_RS24855	COG3629	intracellular signal transduction
C7M71_RS24855	COG3903	Transcriptional regulator
C7M71_RS24880	COG3415	Transposase
C7M71_RS24880	COG2801	Transposase and inactivated derivatives
C7M71_RS24890	COG3387	PFAM Glycoside hydrolase 15-related
C7M71_RS24940	COG1609	Transcriptional regulator
C7M71_RS24950	COG0395	ABC-type sugar transport system, permease component
C7M71_RS25035	COG0747	negative chemotaxis
C7M71_RS25050	COG0444	Belongs to the ABC transporter superfamily
C7M71_RS25055	COG4172	Belongs to the ABC transporter superfamily
C7M71_RS25060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS25080	COG0431	NADPH-dependent FMN reductase
C7M71_RS25095	COG0395	ABC-type sugar transport system, permease component
C7M71_RS25100	COG1175	transmembrane transport
C7M71_RS25115	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C7M71_RS25120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M71_RS25125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M71_RS25130	COG1120	ATPase activity
C7M71_RS25140	COG1132	(ABC) transporter
C7M71_RS25150	COG1132	(ABC) transporter
C7M71_RS25155	COG2382	esterase
C7M71_RS25175	COG0596	Alpha beta hydrolase
C7M71_RS25195	COG0431	NADPH-dependent FMN reductase
C7M71_RS25255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS25270	COG0667	Aldo Keto reductase
C7M71_RS25280	COG0477	Major facilitator Superfamily
C7M71_RS25300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M71_RS25330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS25335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS25340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS25355	COG0601	transmembrane transport
C7M71_RS25400	COG2268	Band 7 protein
C7M71_RS25415	COG1228	amidohydrolase
C7M71_RS25425	COG1132	(ABC) transporter
C7M71_RS25430	COG1408	metallophosphoesterase
C7M71_RS25465	COG2318	DinB family
C7M71_RS25480	COG1132	(ABC) transporter
C7M71_RS25530	COG0745	RESPONSE REGULATOR receiver
C7M71_RS25535	COG2205	protein histidine kinase activity
C7M71_RS25585	COG3953	SLT domain
C7M71_RS25585	COG5280	Phage tail tape measure protein TP901
C7M71_RS25590	COG3424	synthase
C7M71_RS25595	COG2124	cytochrome p450
C7M71_RS25600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7M71_RS25605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7M71_RS25610	COG4948	Mandelate Racemase Muconate Lactonizing
C7M71_RS25620	COG0395	ABC-type sugar transport system, permease component
C7M71_RS25630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7M71_RS25640	COG3866	Pectate lyase
C7M71_RS25645	COG1414	Transcriptional regulator
C7M71_RS25660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7M71_RS25685	COG1309	transcriptional regulator
C7M71_RS25715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7M71_RS25750	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS25775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C7M71_RS25780	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C7M71_RS25805	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C7M71_RS25815	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C7M71_RS25850	COG2197	response regulator
C7M71_RS25865	COG2124	cytochrome p450
C7M71_RS25890	COG3903	Transcriptional regulator
C7M71_RS25890	COG3629	intracellular signal transduction
C7M71_RS25905	COG1819	glycosyl
C7M71_RS25975	COG1120	ATPase activity
C7M71_RS25980	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M71_RS25985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7M71_RS25990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7M71_RS26010	COG1132	(ABC) transporter
C7M71_RS26015	COG1132	(ABC) transporter
C7M71_RS26025	COG2264	protein methyltransferase activity
C7M71_RS26075	COG1120	ATPase activity
C7M71_RS26100	COG2382	esterase
C7M71_RS26105	COG2815	serine threonine protein kinase
C7M71_RS26105	COG0515	serine threonine protein kinase
C7M71_RS26120	COG1335	isochorismatase
C7M71_RS26125	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C7M71_RS26140	COG3012	SEC-C Motif Domain Protein
C7M71_RS26150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS26175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7M71_RS26180	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS26185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7M71_RS26210	COG2124	cytochrome p450
C7M71_RS26230	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS26280	COG1653	transport
C7M71_RS26290	COG0564	pseudouridine synthase activity
C7M71_RS26305	COG0477	Major facilitator Superfamily
C7M71_RS26310	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C7M71_RS26315	COG4260	virion core protein, lumpy skin disease virus
C7M71_RS26335	COG0714	Associated with various cellular activities
C7M71_RS26435	COG0181	hydroxymethylbilane synthase activity
C7M71_RS26460	COG0697	spore germination
C7M71_RS26465	COG1802	Transcriptional regulator
C7M71_RS26545	COG3537	Alpha-1,2-mannosidase
C7M71_RS26555	COG1131	(ABC) transporter
C7M71_RS26570	COG3467	pyridoxamine 5'-phosphate
C7M71_RS26720	COG0667	Aldo Keto reductase
C7M71_RS26730	COG3437	response regulator, receiver
C7M71_RS26730	COG3850	Histidine kinase
C7M71_RS26730	COG4999	Histidine kinase
C7M71_RS26730	COG2205	protein histidine kinase activity
C7M71_RS26755	COG1132	(ABC) transporter
C7M71_RS26770	COG2124	cytochrome p450
C7M71_RS26810	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7M71_RS26810	COG1902	pentaerythritol trinitrate reductase activity
C7M71_RS26815	COG2072	flavoprotein involved in K transport
C7M71_RS26825	COG0626	cystathionine gamma-synthase activity
C7M71_RS26830	COG0393	Putative heavy-metal-binding
C7M71_RS26855	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS26860	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS26880	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS26895	COG0148	phosphopyruvate hydratase activity
C7M71_RS26910	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C7M71_RS26930	COG0596	Alpha beta hydrolase
C7M71_RS26945	COG2362	D-Aminopeptidase
C7M71_RS26955	COG4166	transmembrane transport
C7M71_RS26960	COG0601	transmembrane transport
C7M71_RS26965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7M71_RS27005	COG1132	(ABC) transporter
C7M71_RS27010	COG0667	Aldo Keto reductase
C7M71_RS27035	COG2272	Belongs to the type-B carboxylesterase lipase family
C7M71_RS27045	COG1301	dicarboxylic acid transport
C7M71_RS27050	COG3290	protein histidine kinase activity
C7M71_RS27055	COG4565	transcriptional regulatory protein
C7M71_RS27065	COG2226	methyltransferase
C7M71_RS27090	COG0483	inositol monophosphate 1-phosphatase activity
C7M71_RS27095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7M71_RS27100	COG1505	serine-type exopeptidase activity
C7M71_RS27105	COG2072	flavoprotein involved in K transport
C7M71_RS27120	COG1129	ABC transporter
C7M71_RS27125	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7M71_RS27140	COG3693	PFAM glycoside hydrolase, family 10
C7M71_RS27150	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS27155	COG1132	(ABC) transporter
C7M71_RS27165	COG1063	alcohol dehydrogenase
C7M71_RS27175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C7M71_RS27185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7M71_RS27200	COG0028	Belongs to the TPP enzyme family
C7M71_RS27230	COG0419	ATPase involved in DNA repair
C7M71_RS27235	COG0420	3'-5' exonuclease activity
C7M71_RS27245	COG2755	lipolytic protein G-D-S-L family
C7M71_RS27275	COG1968	undecaprenyl-diphosphatase activity
C7M71_RS27290	COG4209	transmembrane transport
C7M71_RS27295	COG0395	ABC-type sugar transport system, permease component
C7M71_RS27310	COG1404	Belongs to the peptidase S8 family
C7M71_RS27325	COG0436	Aminotransferase
C7M71_RS27340	COG0702	epimerase
C7M71_RS27345	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7M71_RS27390	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS27400	COG2183	response to ionizing radiation
C7M71_RS27415	COG0488	(ABC) transporter
C7M71_RS27420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS27440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7M71_RS27460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C7M71_RS27480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C7M71_RS27485	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C7M71_RS27485	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C7M71_RS27490	COG0859	PFAM glycosyl transferase family 9
C7M71_RS27545	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS27590	COG1704	LemA family
C7M71_RS27605	COG2159	amidohydrolase
C7M71_RS27615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7M71_RS27645	COG0667	Aldo Keto reductase
C7M71_RS27650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS27660	COG0598	Magnesium transport protein CorA
C7M71_RS27680	COG0215	cysteine-tRNA ligase activity
C7M71_RS27690	COG1410	methionine synthase
C7M71_RS27690	COG0646	methionine synthase
C7M71_RS27700	COG4166	transmembrane transport
C7M71_RS27705	COG2197	response regulator
C7M71_RS27715	COG0517	IMP dehydrogenase activity
C7M71_RS27715	COG1994	Peptidase M50
C7M71_RS27735	COG1222	aaa ATPase
C7M71_RS27740	COG4122	O-methyltransferase activity
C7M71_RS27755	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C7M71_RS27770	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C7M71_RS27780	COG0545	Peptidyl-prolyl cis-trans isomerase
C7M71_RS27790	COG2378	regulation of single-species biofilm formation
C7M71_RS27810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7M71_RS27815	COG0805	protein transport
C7M71_RS27830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7M71_RS27835	COG4175	Glycine betaine
C7M71_RS27835	COG0517	IMP dehydrogenase activity
C7M71_RS27840	COG4176	ABC-type proline glycine betaine transport system permease component
C7M71_RS27850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7M71_RS27855	COG2186	Transcriptional regulator
C7M71_RS27865	COG1012	belongs to the aldehyde dehydrogenase family
C7M71_RS27910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7M71_RS27915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7M71_RS27920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7M71_RS27925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7M71_RS27930	COG5002	protein histidine kinase activity
C7M71_RS27935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7M71_RS27940	COG0072	phenylalanine-tRNA ligase activity
C7M71_RS27940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7M71_RS27950	COG1649	PFAM Uncharacterised BCR, COG1649
C7M71_RS27965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7M71_RS27970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7M71_RS27975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7M71_RS27975	COG0723	plastoquinol--plastocyanin reductase activity
C7M71_RS27980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C7M71_RS27985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C7M71_RS27990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7M71_RS27995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7M71_RS28000	COG1438	arginine binding
C7M71_RS28005	COG0137	argininosuccinate synthase activity
C7M71_RS28010	COG0165	Argininosuccinate lyase
C7M71_RS28030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7M71_RS28035	COG2011	ABC-type metal ion transport system permease component
C7M71_RS28040	COG1464	Belongs to the NlpA lipoprotein family
C7M71_RS28045	COG2226	methyltransferase
C7M71_RS28060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C7M71_RS28065	COG1648	precorrin-2 dehydrogenase activity
C7M71_RS28065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7M71_RS28075	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C7M71_RS28115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C7M71_RS28165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7M71_RS28180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7M71_RS28185	COG0596	Alpha beta hydrolase
C7M71_RS28195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7M71_RS28200	COG0318	PFAM AMP-dependent synthetase and ligase
C7M71_RS28205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C7M71_RS28220	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS28220	COG0604	alcohol dehydrogenase
C7M71_RS28220	COG3321	synthase
C7M71_RS28245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7M71_RS28250	COG1560	Kdo2-lipid A biosynthetic process
C7M71_RS28255	COG0438	transferase activity, transferring glycosyl groups
C7M71_RS28265	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C7M71_RS28270	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C7M71_RS28275	COG0217	transcriptional regulatory protein
C7M71_RS28285	COG0632	four-way junction helicase activity
C7M71_RS28290	COG2255	four-way junction helicase activity
C7M71_RS28300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7M71_RS28305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7M71_RS28310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7M71_RS28315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7M71_RS28320	COG1196	nuclear chromosome segregation
C7M71_RS28325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7M71_RS28335	COG0124	histidyl-tRNA synthetase
C7M71_RS28340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7M71_RS28370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7M71_RS28385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7M71_RS28390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7M71_RS28395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7M71_RS28405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7M71_RS28410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7M71_RS28415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7M71_RS28420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7M71_RS28425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C7M71_RS28435	COG0006	proline dipeptidase activity
C7M71_RS28440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7M71_RS28445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7M71_RS28455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C7M71_RS28460	COG0540	Belongs to the ATCase OTCase family
C7M71_RS28465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7M71_RS28475	COG0505	Belongs to the CarA family
C7M71_RS28480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7M71_RS28485	COG0167	dihydroorotate dehydrogenase activity
C7M71_RS28490	COG0284	orotidine-5'-phosphate decarboxylase activity
C7M71_RS28500	COG0194	GDP metabolic process
C7M71_RS28515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7M71_RS28550	COG0242	peptide deformylase activity
C7M71_RS28555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7M71_RS28565	COG4106	trans-aconitate 2-methyltransferase activity
C7M71_RS28580	COG1174	glycine betaine transport
C7M71_RS28590	COG0667	Aldo Keto reductase
C7M71_RS28595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7M71_RS28610	COG0542	response to heat
C7M71_RS28630	COG3201	nicotinamide mononucleotide transporter
C7M71_RS28635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7M71_RS28635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C7M71_RS28640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7M71_RS28645	COG0140	phosphoribosyl-ATP diphosphatase activity
C7M71_RS28650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C7M71_RS28660	COG1253	flavin adenine dinucleotide binding
C7M71_RS28665	COG1253	flavin adenine dinucleotide binding
C7M71_RS28675	COG3903	Transcriptional regulator
C7M71_RS28675	COG3629	intracellular signal transduction
C7M71_RS28680	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS28695	COG1228	amidohydrolase
C7M71_RS28705	COG0463	Glycosyl transferase, family 2
C7M71_RS28710	COG3030	protein affecting phage T7 exclusion by the F plasmid
C7M71_RS28720	COG2270	Major facilitator Superfamily
C7M71_RS28735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7M71_RS28755	COG1902	pentaerythritol trinitrate reductase activity
C7M71_RS28840	COG2329	Antibiotic biosynthesis monooxygenase
C7M71_RS28845	COG0662	Cupin 2, conserved barrel domain protein
C7M71_RS28865	COG2867	negative regulation of translational initiation
C7M71_RS28895	COG0477	Major facilitator Superfamily
C7M71_RS28925	COG4221	oxidoreductase activity
C7M71_RS28935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C7M71_RS28945	COG2362	D-Aminopeptidase
C7M71_RS28950	COG1846	Transcriptional regulator
C7M71_RS28955	COG0477	Major facilitator Superfamily
C7M71_RS28980	COG3220	belongs to the UPF0276 family
C7M71_RS29000	COG1609	Transcriptional regulator
C7M71_RS29005	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7M71_RS29010	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7M71_RS29015	COG1129	ABC transporter
C7M71_RS29020	COG1879	ABC-type sugar transport system periplasmic component
C7M71_RS29050	COG2226	methyltransferase
C7M71_RS29080	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS29120	COG0477	Major facilitator Superfamily
C7M71_RS29145	COG0412	Dienelactone hydrolase
C7M71_RS29160	COG1609	Transcriptional regulator
C7M71_RS29165	COG0738	Major facilitator superfamily
C7M71_RS29170	COG0531	amino acid
C7M71_RS29175	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS29195	COG2124	cytochrome p450
C7M71_RS29220	COG2268	Band 7 protein
C7M71_RS29230	COG1309	transcriptional regulator
C7M71_RS29275	COG3845	ABC transporter
C7M71_RS29305	COG2226	methyltransferase
C7M71_RS29315	COG2409	Drug exporters of the RND superfamily
C7M71_RS29335	COG0701	Predicted permease
C7M71_RS29365	COG2813	Specifically methylates the guanine in position
C7M71_RS29400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7M71_RS29405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7M71_RS29410	COG0019	diaminopimelate decarboxylase activity
C7M71_RS29430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C7M71_RS29450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7M71_RS29460	COG1024	Enoyl-CoA hydratase
C7M71_RS29510	COG3483	tryptophan 2,3-dioxygenase activity
C7M71_RS29520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7M71_RS29540	COG3469	chitinase activity
C7M71_RS29565	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C7M71_RS29565	COG2508	Transcriptional regulator
C7M71_RS29570	COG0019	diaminopimelate decarboxylase activity
C7M71_RS29580	COG0531	amino acid
C7M71_RS29610	COG1414	Transcriptional regulator
C7M71_RS29615	COG0747	negative chemotaxis
C7M71_RS29620	COG0444	Belongs to the ABC transporter superfamily
C7M71_RS29625	COG4608	Belongs to the ABC transporter superfamily
C7M71_RS29650	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C7M71_RS29655	COG0800	Aldolase
C7M71_RS29665	COG1414	Transcriptional regulator
C7M71_RS29670	COG0251	oxidation-reduction process
C7M71_RS29690	COG4106	trans-aconitate 2-methyltransferase activity
C7M71_RS29710	COG1802	Transcriptional regulator
C7M71_RS29720	COG2197	response regulator
C7M71_RS29725	COG4585	Histidine kinase
C7M71_RS29730	COG1136	(ABC) transporter
C7M71_RS29790	COG0444	Belongs to the ABC transporter superfamily
C7M71_RS29800	COG0601	transmembrane transport
C7M71_RS29810	COG1609	Transcriptional regulator
C7M71_RS29815	COG3387	PFAM Glycoside hydrolase 15-related
C7M71_RS29860	COG1902	pentaerythritol trinitrate reductase activity
C7M71_RS29890	COG0693	protein deglycase activity
C7M71_RS29905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C7M71_RS29915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7M71_RS29930	COG1920	GTP binding
C7M71_RS29935	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C7M71_RS29940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C7M71_RS29945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C7M71_RS29955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C7M71_RS29975	COG1953	Uracil, thiamine, allantoin
C7M71_RS30015	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS30095	COG0596	Alpha beta hydrolase
C7M71_RS30145	COG4555	ABC transporter
C7M71_RS30160	COG0148	phosphopyruvate hydratase activity
C7M71_RS30185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7M71_RS30200	COG0154	amidase activity
C7M71_RS30225	COG0667	Aldo Keto reductase
C7M71_RS30230	COG3663	DNA glycosylase
C7M71_RS30260	COG1028	Short-chain dehydrogenase reductase Sdr
C7M71_RS30270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7M71_RS30275	COG0798	PFAM Bile acid sodium symporter
C7M71_RS30280	COG0640	Transcriptional regulator
C7M71_RS30285	COG4941	Belongs to the sigma-70 factor family
C7M71_RS30290	COG3795	YCII-related domain
C7M71_RS30325	COG0583	DNA-binding transcription factor activity
C7M71_RS30330	COG0346	lactoylglutathione lyase activity
C7M71_RS30340	COG0183	Belongs to the thiolase family
C7M71_RS30370	COG1960	acyl-CoA dehydrogenase activity
C7M71_RS30380	COG1802	Transcriptional regulator
C7M71_RS30420	COG2801	Transposase and inactivated derivatives
C7M71_RS30565	COG0629	single-stranded DNA binding
C7M71_RS30855	COG0438	transferase activity, transferring glycosyl groups