locus-tag class description GXP74_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GXP74_RS00015 ENOG4108J5G 6-phosphogluconate dehydrogenase GXP74_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GXP74_RS00025 ENOG4105K7N UPF0232 protein GXP74_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXP74_RS00095 ENOG4107ZXI Rhomboid family GXP74_RS00100 ENOG4105ZJT Cell division protein CrgA GXP74_RS00115 ENOG4108U4N (sortase) family GXP74_RS00120 ENOG4108RN7 integral membrane protein GXP74_RS00150 ENOG4105HZM Fha domain containing protein GXP74_RS00155 ENOG4105TV9 FHA Domain-Containing protein GXP74_RS00155 ENOG4105TV9 FHA Domain-Containing protein GXP74_RS00170 ENOG41069HH 4-oxalocrotonate tautomerase GXP74_RS00175 ENOG4105EYF MMPL domain protein GXP74_RS00185 ENOG4108MJI response regulator GXP74_RS00195 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GXP74_RS00200 ENOG4105J5T Amp-dependent synthetase and ligase GXP74_RS00210 ENOG4107QSN dihydrolipoamide acetyltransferase GXP74_RS00225 ENOG4108XM1 transcriptional regulator AsnC family GXP74_RS00230 ENOG4108IG5 Transcriptional regulator GXP74_RS00250 ENOG4105D5Q Arginine ornithine antiporter GXP74_RS00260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GXP74_RS00265 ENOG4105F38 ABC transporter, permease GXP74_RS00270 ENOG4105D38 putrescine abc transporter GXP74_RS00285 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GXP74_RS00290 ENOG4108Z6Z Transcriptional regulator GXP74_RS00295 ENOG4105C3M thioredoxin reductase GXP74_RS00310 ENOG41082T9 Membrane GXP74_RS00315 ENOG4106048 Cupin 2, conserved barrel domain protein GXP74_RS00320 ENOG4105ETU transcriptional activator (TenA GXP74_RS00330 ENOG4105DZ6 Band 7 protein GXP74_RS00350 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GXP74_RS00385 ENOG4107P2S Transcriptional regulator GXP74_RS00390 ENOG4105CIH Imidazole acetol-phosphate transaminase GXP74_RS00400 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GXP74_RS00415 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GXP74_RS00420 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GXP74_RS00430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXP74_RS00435 ENOG4105BZU Histidine kinase GXP74_RS00440 ENOG4105C4M (Ubiquinol oxidase) subunit I GXP74_RS00445 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GXP74_RS00455 ENOG4108K4B hydrolase GXP74_RS00525 ENOG4105CJ1 ABC, transporter GXP74_RS00550 ENOG41073TP transcriptional regulator GXP74_RS00555 ENOG410667J hydrolase GXP74_RS00560 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GXP74_RS00570 ENOG4105DBE peroxidase GXP74_RS00610 ENOG4107T6F Xaa-Pro aminopeptidase GXP74_RS00630 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GXP74_RS00650 ENOG4105C0H protease GXP74_RS00720 ENOG41060M0 Crispr-associated protein, cse4 family GXP74_RS00735 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GXP74_RS00740 ENOG4105PWE CRISPR-associated protein cas2 GXP74_RS00765 ENOG4105DQE DNA ligase GXP74_RS00800 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GXP74_RS00805 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GXP74_RS00885 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS00930 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GXP74_RS00965 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GXP74_RS00985 ENOG4105EQX glucarate dehydratase GXP74_RS00995 ENOG4105M2Z protein tyrosine serine phosphatase GXP74_RS01000 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXP74_RS01005 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXP74_RS01010 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein GXP74_RS01030 ENOG4105BZ4 penicillin-binding protein GXP74_RS01060 ENOG4108Z6B deaminase GXP74_RS01075 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GXP74_RS01095 ENOG4105D7N magnesium and cobalt transport protein CorA GXP74_RS01105 ENOG4105DKQ ROK family GXP74_RS01120 ENOG4105DZ6 Band 7 protein GXP74_RS01140 ENOG4105D17 glycoside hydrolase, family 3 domain protein GXP74_RS01155 ENOG41064MX Tetr family transcriptional regulator GXP74_RS01160 ENOG41064MX Tetr family transcriptional regulator GXP74_RS01185 ENOG4105CPC Aldo Keto reductase GXP74_RS01225 ENOG4105CPC Aldo Keto reductase GXP74_RS01230 ENOG4105EMU Dehydrogenase GXP74_RS01295 ENOG4108RZE Tetr family transcriptional regulator GXP74_RS01300 ENOG4105EYF MMPL domain protein GXP74_RS01305 ENOG4105N14 lysine exporter protein LysE YggA GXP74_RS01325 ENOG4107Z3H Transcriptional regulator, TetR family GXP74_RS01340 ENOG4105CZV ABC transporter GXP74_RS01350 ENOG4105BZU Histidine kinase GXP74_RS01355 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS01375 ENOG4108JU3 Alkyl hydroperoxide reductase GXP74_RS01490 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXP74_RS01550 ENOG4105C3M thioredoxin reductase GXP74_RS01560 ENOG4105HS2 Arsenate reductase GXP74_RS01570 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GXP74_RS01580 ENOG4108Z7F N-acetyltransferase GXP74_RS01585 ENOG41082YX Transcriptional regulator, arsr family GXP74_RS01640 ENOG4106CY5 excisionase GXP74_RS01645 ENOG4107T65 Integrase GXP74_RS01730 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GXP74_RS01760 ENOG4105I1F Resistance protein GXP74_RS01770 ENOG4107ZVI PhiRv2 prophage protein GXP74_RS01780 ENOG4106CY5 excisionase GXP74_RS01785 ENOG4107T65 Integrase GXP74_RS01805 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GXP74_RS01810 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GXP74_RS01820 ENOG4105CFH Aspartokinase GXP74_RS01825 ENOG4105NAF rna polymerase sigma factor GXP74_RS01845 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GXP74_RS01865 ENOG4105CPC Aldo Keto reductase GXP74_RS01895 ENOG4105BZ4 penicillin-binding protein GXP74_RS01930 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GXP74_RS01980 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GXP74_RS02020 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GXP74_RS02035 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GXP74_RS02135 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) GXP74_RS02165 ENOG4107Q3C acyl-Coa dehydrogenase GXP74_RS02170 ENOG4107RCI amp-dependent synthetase and ligase GXP74_RS02195 ENOG4108S93 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GXP74_RS02200 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GXP74_RS02205 ENOG4105M6F mutator MutT protein GXP74_RS02240 ENOG4105C0W non-ribosomal peptide synthetase GXP74_RS02250 ENOG4105C5I Dehydrogenase GXP74_RS02260 ENOG4107H8F GXP74_RS02300 ENOG4105P8F nudix hydrolase GXP74_RS02320 ENOG4105D74 hydrolase GXP74_RS02330 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GXP74_RS02335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GXP74_RS02340 ENOG4107B2H carbonic anhydrase GXP74_RS02395 ENOG4108I5C dEAD DEAH box helicase GXP74_RS02400 ENOG4105WN5 stage II sporulation protein GXP74_RS02405 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GXP74_RS02410 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GXP74_RS02420 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GXP74_RS02430 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GXP74_RS02435 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GXP74_RS02440 ENOG4107QRG dna polymerase iii GXP74_RS02455 ENOG4108NIW Leucine export protein LeuE GXP74_RS02515 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS02680 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GXP74_RS02685 ENOG4105EUJ GTP cyclohydrolase i GXP74_RS02700 ENOG4108EJ0 Catalyzes the synthesis of activated sulfate (By similarity) GXP74_RS02720 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GXP74_RS02765 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXP74_RS02905 ENOG4105CDU Replicative dna helicase GXP74_RS03010 ENOG4105DQQ Major facilitator superfamily MFS_1 GXP74_RS03020 ENOG4107QZF nitrite reductase NADPH large subunit GXP74_RS03025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXP74_RS03030 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GXP74_RS03040 ENOG4105K78 MarR family Transcriptional regulator GXP74_RS03055 ENOG410834F Transcriptional regulator GXP74_RS03070 ENOG4105CHR reductase GXP74_RS03075 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GXP74_RS03085 ENOG4105Q56 cytochrome P450 GXP74_RS03120 ENOG4105CPC Aldo Keto reductase GXP74_RS03135 ENOG4105CZS beta-ketoacyl synthase GXP74_RS03170 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) GXP74_RS03225 ENOG4105E39 Enoyl-CoA hydratase GXP74_RS03230 ENOG4105CHR reductase GXP74_RS03260 ENOG4105BZ1 (ABC) transporter GXP74_RS03265 ENOG4105BZ1 (ABC) transporter GXP74_RS03270 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GXP74_RS03275 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GXP74_RS03280 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GXP74_RS03285 ENOG4108HHA Transketolase GXP74_RS03290 ENOG4108IUS Transketolase GXP74_RS03305 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GXP74_RS03310 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS03315 ENOG4107EEY synthase GXP74_RS03330 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS03340 ENOG4105CHR reductase GXP74_RS03355 ENOG4108URH decarboxylase GXP74_RS03370 ENOG4105CJ1 ABC, transporter GXP74_RS03385 ENOG4105C5S asparaginyl-tRNA synthetase GXP74_RS03395 ENOG4105C0D helicase GXP74_RS03405 ENOG4105C19 ABC transporter GXP74_RS03410 ENOG4105GRZ Ycii-related protein GXP74_RS03415 ENOG4105CHP RNA polymerase GXP74_RS03440 ENOG4105CC5 ABC transporter GXP74_RS03445 ENOG4105CC5 ABC transporter GXP74_RS03450 ENOG4105FDK ABC transporter GXP74_RS03480 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS03485 ENOG4107S2Z UPF0761 membrane protein GXP74_RS03495 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS03505 ENOG4105EQ0 Major Facilitator superfamily GXP74_RS03510 ENOG4108JGH Tetr family transcriptional regulator GXP74_RS03525 ENOG4108X7A Terpene synthase metal-binding domain-containing protein GXP74_RS03530 ENOG4107SM8 Adenylate Guanylate cyclase GXP74_RS03535 ENOG41080RH Thioredoxin GXP74_RS03560 ENOG4105DBE peroxidase GXP74_RS03600 ENOG4105F0N pyrophosphate phospho-hydrolase GXP74_RS03615 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GXP74_RS03630 ENOG4105EUJ GTP cyclohydrolase i GXP74_RS03645 ENOG4105CRK lysyL-tRNA synthetase GXP74_RS03650 ENOG4105EEI dihydropteroate synthase GXP74_RS03665 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GXP74_RS03700 ENOG4105ESN nucleotide-binding protein GXP74_RS03710 ENOG4108ZBR Gcn5-related n-acetyltransferase GXP74_RS03720 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GXP74_RS03730 ENOG4105BZU Histidine kinase GXP74_RS03740 ENOG4105CE4 GlcNAc 6-P deacetylase GXP74_RS03785 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GXP74_RS03790 ENOG4105C3Q Glycosyl transferase, family 2 GXP74_RS03840 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GXP74_RS03845 ENOG4105EEM helicase GXP74_RS03860 ENOG4105CFI type iii restriction protein res subunit GXP74_RS03865 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GXP74_RS03895 ENOG4105VEQ Cold shock protein GXP74_RS03900 ENOG4105E63 Pfam:DUF178 GXP74_RS03905 ENOG4108UIH futalosine nucleosidase GXP74_RS03915 ENOG4108N0W Major Facilitator superfamily GXP74_RS03955 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GXP74_RS03960 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GXP74_RS03965 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GXP74_RS03970 ENOG4108VVK transcriptional Regulator, AsnC GXP74_RS03975 ENOG4105C7B Threonine dehydratase GXP74_RS03980 ENOG4105DVY radical SAM domain protein GXP74_RS03995 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GXP74_RS04005 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GXP74_RS04015 ENOG4108SU4 UPF0309 protein GXP74_RS04055 ENOG4107SJB teichoic acid biosynthesis GXP74_RS04065 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GXP74_RS04075 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS04090 ENOG4105CC9 acyl-Coa dehydrogenase GXP74_RS04095 ENOG4105D2B acyl-CoA dehydrogenase GXP74_RS04110 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GXP74_RS04115 ENOG4105CC9 acyl-Coa dehydrogenase GXP74_RS04125 ENOG4107QPD alcohol dehydrogenase GXP74_RS04140 ENOG4105YVS arsR family transcriptional regulator GXP74_RS04155 ENOG4105VEQ Cold shock protein GXP74_RS04160 ENOG4105EV6 Pfam:DUF178 GXP74_RS04165 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GXP74_RS04175 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXP74_RS04200 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS04205 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GXP74_RS04210 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS04220 ENOG4107QIZ NADH dehydrogenase GXP74_RS04225 ENOG4108IEH NADH dehydrogenase subunit g GXP74_RS04230 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GXP74_RS04235 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS04240 ENOG4105DF2 NADH dehydrogenase subunit j GXP74_RS04245 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS04250 ENOG4105D65 subunit l GXP74_RS04260 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS04275 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GXP74_RS04280 ENOG4105DQU oxidoreductase, subunit beta GXP74_RS04300 ENOG4105MVE transcriptional regulator GXP74_RS04315 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GXP74_RS04320 ENOG4105M2Z protein tyrosine serine phosphatase GXP74_RS04325 ENOG4105C54 Major Facilitator superfamily GXP74_RS04360 ENOG41061WM D-Alanyl-D-Alanine GXP74_RS04385 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS04390 ENOG4105BZU Histidine kinase GXP74_RS04430 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXP74_RS04495 ENOG4108KPJ rna polymerase sigma factor GXP74_RS04510 ENOG4105VUF Transcriptional regulator GXP74_RS04530 ENOG4105CHR reductase GXP74_RS04545 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS04555 ENOG4107WI4 Aldose-1-epimerase GXP74_RS04565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXP74_RS04570 ENOG4105BZU Histidine kinase GXP74_RS04575 ENOG4105EDW glycosyl transferase, family 39 GXP74_RS04590 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GXP74_RS04595 ENOG4106A3M Cytochrome p-450 GXP74_RS04605 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GXP74_RS04630 ENOG4105CRP Part of the ABC transporter FtsEX involved in GXP74_RS04635 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GXP74_RS04660 ENOG4105CHU acetyl-coa acetyltransferase GXP74_RS04700 ENOG4107ZXI Rhomboid family GXP74_RS04710 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GXP74_RS04725 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GXP74_RS04730 ENOG4105C7B Threonine dehydratase GXP74_RS04765 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GXP74_RS04775 ENOG4105T1M mycothiol conjugate amidase mca GXP74_RS04785 ENOG4105D9G High-affinity GXP74_RS04800 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GXP74_RS04825 ENOG4105C7Z Conserved Protein GXP74_RS04850 ENOG4105C7Z Conserved Protein GXP74_RS04860 ENOG4105C57 major facilitator superfamily GXP74_RS04870 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) GXP74_RS04880 ENOG4105CHM Aminotransferase GXP74_RS04905 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) GXP74_RS04915 ENOG4105CPC Aldo Keto reductase GXP74_RS04920 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GXP74_RS04925 ENOG4108IAB Phoh family GXP74_RS04940 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GXP74_RS04945 ENOG4105D3R alkyl hydroperoxide reductase GXP74_RS04965 ENOG4105EUB pirin domain protein GXP74_RS04990 ENOG4105C9Q fumarate hydratase class II GXP74_RS05000 ENOG4107GFK fumarate GXP74_RS05025 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GXP74_RS05035 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GXP74_RS05040 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GXP74_RS05055 ENOG4105C3G gtp-binding protein GXP74_RS05060 ENOG41084HI prevent-host-death family GXP74_RS05065 ENOG4105KRQ Addiction module toxin, Txe YoeB family GXP74_RS05080 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GXP74_RS05100 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GXP74_RS05120 ENOG4105CI3 gtp-binding protein typa GXP74_RS05130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXP74_RS05135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS05145 ENOG4108JQ7 (ABC) transporter GXP74_RS05155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS05180 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GXP74_RS05200 ENOG4108M15 ABC transporter GXP74_RS05210 ENOG4105BZU Histidine kinase GXP74_RS05215 ENOG4108S01 response regulator GXP74_RS05225 ENOG41063JG Transcriptional regulator GXP74_RS05235 ENOG4108Z4U Ferredoxin GXP74_RS05255 ENOG4107R4C succinyl-diaminopimelate desuccinylase GXP74_RS05260 ENOG4108URH decarboxylase GXP74_RS05265 ENOG4105EEI dihydropteroate synthase GXP74_RS05275 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GXP74_RS05280 ENOG4105CGU Enoyl-CoA hydratase GXP74_RS05290 ENOG4107ZBN O-methyltransferase GXP74_RS05305 ENOG4105C0H protease GXP74_RS05310 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GXP74_RS05330 ENOG4105CJW magnesium transporter GXP74_RS05375 ENOG4105C1J atp-dependent rna helicase GXP74_RS05415 ENOG4105CPK Glycosyl transferase (Group 1 GXP74_RS05480 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GXP74_RS05490 ENOG4105FDP GntR family transcriptional regulator GXP74_RS05510 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXP74_RS05560 ENOG41063PX domain protein GXP74_RS05595 ENOG4107TK4 histidinol-phosphate phosphatase GXP74_RS05600 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GXP74_RS05610 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GXP74_RS05615 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GXP74_RS05625 ENOG4108RAV Conserved protein GXP74_RS05630 ENOG4105EMN RNA polymerase sigma factor GXP74_RS05635 ENOG4105WMN AntiSigma factor GXP74_RS05645 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXP74_RS05705 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GXP74_RS05710 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GXP74_RS05730 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GXP74_RS05760 ENOG4105EDW glycosyl transferase, family 39 GXP74_RS05775 ENOG4105E98 transcriptional regulator DeoR family GXP74_RS05780 ENOG4108JIK carboxylase GXP74_RS05795 ENOG4107WR6 Maf-like protein GXP74_RS05805 ENOG4105D8K carboxyl transferase GXP74_RS05815 ENOG4108QER Adenylate cyclase GXP74_RS05820 ENOG4105KDM Diguanylate cyclase with gaf sensor GXP74_RS05825 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GXP74_RS05830 ENOG4105C84 Histidine ammonia-lyase GXP74_RS05865 ENOG4105CGP Urocanate hydratase GXP74_RS05880 ENOG4105CI2 imidazolone-5-propionate hydrolase GXP74_RS05885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXP74_RS05890 ENOG41065SU Two-component system sensor kinase GXP74_RS05905 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GXP74_RS05920 ENOG4108IUX (ABC) transporter GXP74_RS05925 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GXP74_RS05930 ENOG4105K4P CoA-binding domain protein GXP74_RS05935 ENOG4105C6Y Udp-glucose 6-dehydrogenase GXP74_RS05940 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS05945 ENOG4105C84 Histidine ammonia-lyase GXP74_RS05950 ENOG4105KPY Small multidrug resistance protein GXP74_RS05955 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GXP74_RS05980 ENOG4105FDP GntR family transcriptional regulator GXP74_RS05990 ENOG4108KGH TRANSCRIPTIONal GXP74_RS06020 ENOG4105EB3 Histidine kinase GXP74_RS06025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXP74_RS06035 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXP74_RS06040 ENOG4107RGC Glycosyl transferase, family 2 GXP74_RS06060 ENOG4107QKV phosphomannomutase GXP74_RS06065 ENOG4105W49 UPF0434 protein GXP74_RS06075 ENOG4105EIP mannose-6-phosphate isomerase GXP74_RS06085 ENOG4108115 UPF0145 protein GXP74_RS06095 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GXP74_RS06125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXP74_RS06130 ENOG4105BZU Histidine kinase GXP74_RS06135 ENOG4105G3P Lipoprotein lpqB GXP74_RS06140 ENOG4105MJ2 Competence protein GXP74_RS06145 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GXP74_RS06150 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS06155 ENOG4105T0Z Conserved Protein GXP74_RS06160 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GXP74_RS06180 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GXP74_RS06200 ENOG4105C7I Dehydrogenase GXP74_RS06210 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GXP74_RS06210 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GXP74_RS06215 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component GXP74_RS06220 ENOG4105EPJ extracellular solute-binding protein family 1 GXP74_RS06230 ENOG4105EC2 ftsk spoIIIe GXP74_RS06235 ENOG4108UGD Serine Threonine protein kinase GXP74_RS06240 ENOG4108QVN serine threonine protein kinase GXP74_RS06245 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GXP74_RS06260 ENOG4105CAK Cell division ATP-binding protein ftsE GXP74_RS06270 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GXP74_RS06280 ENOG4105EEM helicase GXP74_RS06290 ENOG4108426 dNA-binding protein GXP74_RS06295 ENOG4105CJR Integral membrane protein (MviN GXP74_RS06300 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GXP74_RS06305 ENOG4108UJU UPF0301 protein GXP74_RS06315 ENOG4105E2D ec 3.2.1.52 GXP74_RS06340 ENOG4105C6X Major Facilitator GXP74_RS06355 ENOG41063PX domain protein GXP74_RS06365 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GXP74_RS06370 ENOG4105CQB FAD linked oxidase domain protein GXP74_RS06380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXP74_RS06385 ENOG41065SU Two-component system sensor kinase GXP74_RS06390 ENOG4107SMB hydrolase Family 5 GXP74_RS06400 ENOG4105KF0 sporulation and cell division protein, SsgA GXP74_RS06425 ENOG4108RWI nicotinamidase GXP74_RS06435 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GXP74_RS06465 ENOG4108RQ5 Beta-lactamase domain-containing protein GXP74_RS06480 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GXP74_RS06485 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GXP74_RS06520 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GXP74_RS06530 ENOG4105BZ4 penicillin-binding protein GXP74_RS06560 ENOG4105E2D ec 3.2.1.52 GXP74_RS06570 ENOG4106BRA Membrane GXP74_RS06575 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GXP74_RS06580 ENOG4105MWK D-amino acid dehydrogenase, small subunit GXP74_RS06605 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GXP74_RS06630 ENOG4105DRS transport system, permease GXP74_RS06640 ENOG4105CN5 Metallo-Beta-Lactamase GXP74_RS06645 ENOG4105C0X amino acid GXP74_RS06680 ENOG4105D8K carboxyl transferase GXP74_RS06690 ENOG4106UDK Cellulose-binding, family II GXP74_RS06695 ENOG4105K6H D-cysteine desulfhydrase GXP74_RS06700 ENOG4105DEN Luciferase family GXP74_RS06715 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase GXP74_RS06745 ENOG4108Z4X TRANSCRIPTIONal GXP74_RS06775 ENOG4105MSB protein, conserved in bacteria GXP74_RS06790 ENOG41064MX Tetr family transcriptional regulator GXP74_RS06800 ENOG4107XI7 Tetr family transcriptional regulator GXP74_RS06840 ENOG4108ZM9 phosphoglycerate mutase GXP74_RS06875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS06880 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXP74_RS06885 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS06900 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS06920 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GXP74_RS06925 ENOG4105ECQ AraC Family Transcriptional Regulator GXP74_RS06940 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS06945 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GXP74_RS06955 ENOG4107QX3 carboxylase GXP74_RS06965 ENOG4105KVH Transcriptional regulator GXP74_RS06975 ENOG410905P Pyridoxamine 5-phosphate GXP74_RS07050 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GXP74_RS07065 ENOG4108V06 Glutathione peroxidase GXP74_RS07070 ENOG4105C7H Helicase, RecD TraA family GXP74_RS07105 ENOG4105Y3U Transglycosylase-associated protein GXP74_RS07120 ENOG410834F Transcriptional regulator GXP74_RS07125 ENOG4105CQ7 ATP-dependent helicase GXP74_RS07135 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GXP74_RS07165 ENOG4105VHU single-stranded DNA-binding protein GXP74_RS07185 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GXP74_RS07195 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GXP74_RS07205 ENOG4105DJ2 Major Facilitator Superfamily GXP74_RS07255 ENOG4105DEN Luciferase family GXP74_RS07330 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GXP74_RS07405 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GXP74_RS07410 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GXP74_RS07430 ENOG4105K5B UPF0225 protein GXP74_RS07450 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GXP74_RS07485 ENOG4105EAB amino acid AbC transporter GXP74_RS07495 ENOG410825M Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GXP74_RS07510 ENOG4105F8D glycoside hydrolase family 4 GXP74_RS07525 ENOG4105D8X mechanosensitive ion channel GXP74_RS07570 ENOG4105MC2 DSBA oxidoreductase GXP74_RS07575 ENOG4107ZYJ bioY protein GXP74_RS07580 ENOG4108YZG isomerase GXP74_RS07635 ENOG4105D85 methylase GXP74_RS07655 ENOG4105CZE histidine utilization repressor GXP74_RS07715 ENOG4105C0R drug resistance transporter emrb qaca subfamily GXP74_RS07720 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GXP74_RS07725 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GXP74_RS07730 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GXP74_RS07735 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GXP74_RS07750 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GXP74_RS07760 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GXP74_RS07770 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GXP74_RS07775 ENOG4105DFF Rod shape-determining protein mreb GXP74_RS07790 ENOG4105CJN penicillin-binding protein GXP74_RS07795 ENOG4105CNI cell division protein FtsW GXP74_RS07850 ENOG4105VMP Transcriptional regulator GXP74_RS07875 ENOG4105C03 ribonuclease GXP74_RS07880 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GXP74_RS07885 ENOG4105K46 50S ribosomal protein l27 GXP74_RS07890 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GXP74_RS07900 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GXP74_RS07910 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GXP74_RS07940 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GXP74_RS07955 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GXP74_RS07990 ENOG4107QQG Dehydrogenase GXP74_RS07995 ENOG4106WTF Glycosyl transferase, family 2 GXP74_RS08010 ENOG4105C8T Leucyl-tRNA synthetase GXP74_RS08020 ENOG4105EPR degv family GXP74_RS08045 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GXP74_RS08050 ENOG41061CK Antibiotic biosynthesis monooxygenase GXP74_RS08060 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GXP74_RS08105 ENOG4105D0M Protease HtpX homolog GXP74_RS08110 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GXP74_RS08115 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GXP74_RS08125 ENOG4107RE3 peptidase, S41 GXP74_RS08130 ENOG4107YU2 histidine triad (hIT) protein GXP74_RS08135 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GXP74_RS08145 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GXP74_RS08170 ENOG4105CH2 amidohydrolase GXP74_RS08200 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GXP74_RS08205 ENOG41060NJ transcriptional regulator GXP74_RS08210 ENOG4108J2P Alpha beta hydrolase fold GXP74_RS08215 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GXP74_RS08225 ENOG4105D4Y metalloprotease GXP74_RS08230 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GXP74_RS08240 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GXP74_RS08245 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GXP74_RS08255 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GXP74_RS08275 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS08320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GXP74_RS08345 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GXP74_RS08370 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GXP74_RS08380 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GXP74_RS08385 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXP74_RS08425 ENOG4108VJY integral membrane protein GXP74_RS08435 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GXP74_RS08455 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GXP74_RS08460 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXP74_RS08480 ENOG4107S1E Beta-lactamase GXP74_RS08485 ENOG4105VUF Transcriptional regulator GXP74_RS08490 ENOG4105CPC Aldo Keto reductase GXP74_RS08510 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GXP74_RS08540 ENOG41086VY Fic/DOC family GXP74_RS08555 ENOG4105DKQ ROK family GXP74_RS08580 ENOG4105DAX Pfam:DUF2983 GXP74_RS08610 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GXP74_RS08645 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GXP74_RS08775 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GXP74_RS08790 ENOG4105CPC Aldo Keto reductase GXP74_RS08810 ENOG4106A3M Cytochrome p-450 GXP74_RS08815 ENOG4105F2C Acetyl-CoA acetyltransferase GXP74_RS08830 ENOG4105BZ1 (ABC) transporter GXP74_RS08865 ENOG4108SGK Tetr family transcriptional regulator GXP74_RS08870 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GXP74_RS08875 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXP74_RS08890 ENOG4105DYW oxidoreductase GXP74_RS08940 ENOG4105CHR reductase GXP74_RS08960 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GXP74_RS08965 ENOG4105EGD dinuclear metal center protein, YbgI family GXP74_RS08980 ENOG4107XFJ UPF0246 protein GXP74_RS09155 ENOG4105CHP RNA polymerase GXP74_RS09180 ENOG4106UW1 Major Facilitator superfamily GXP74_RS09230 ENOG41082SX arsR family transcriptional regulator GXP74_RS09245 ENOG41065RQ ADP-ribosylation crystallin J1 GXP74_RS09265 ENOG4105EGE secreted protein GXP74_RS09270 ENOG4106UDK Cellulose-binding, family II GXP74_RS09275 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS09285 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GXP74_RS09345 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GXP74_RS09380 ENOG4107XZ0 Peptidase M50 GXP74_RS09435 ENOG4105BZ4 penicillin-binding protein GXP74_RS09440 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GXP74_RS09445 ENOG4105C57 major facilitator superfamily GXP74_RS09450 ENOG4108JGH Tetr family transcriptional regulator GXP74_RS09460 ENOG4105C4K Nad synthetase GXP74_RS09465 ENOG4105C5F glutamine synthetase GXP74_RS09480 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GXP74_RS09500 ENOG4106HK8 GPR1 FUN34 yaaH family protein GXP74_RS09515 ENOG4105HSS phospholipase C GXP74_RS09540 ENOG4108HR6 Dehydrogenase GXP74_RS09545 ENOG4105C7W Xanthine dehydrogenase GXP74_RS09555 ENOG4105F4R Transcriptional regulator mode GXP74_RS09615 ENOG4105CHP RNA polymerase GXP74_RS09630 ENOG4105EMU Dehydrogenase GXP74_RS09650 ENOG4105DEN Luciferase family GXP74_RS09665 ENOG4105C9U ATP-dependent DNA helicase RecQ GXP74_RS09725 ENOG4107TXC Transcriptional regulator GXP74_RS09770 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GXP74_RS09775 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GXP74_RS09780 ENOG4108FN7 Aldo keto reductase GXP74_RS09785 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GXP74_RS09805 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GXP74_RS09825 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GXP74_RS09830 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GXP74_RS09835 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GXP74_RS09855 ENOG4105CPC Aldo Keto reductase GXP74_RS09860 ENOG4105DXX methyltransferase GXP74_RS09880 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GXP74_RS09890 ENOG4105F7P transcriptional regulator AsnC family GXP74_RS09895 ENOG4105DY8 decarboxylase GXP74_RS09920 ENOG4107T4Z adenosine kinase GXP74_RS09925 ENOG4105C3J Cysteine desulfurase GXP74_RS09930 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GXP74_RS09935 ENOG4105BZ9 Cytochrome C oxidase, subunit I GXP74_RS09940 ENOG4105MCD Part of cytochrome c oxidase, its function is GXP74_RS09945 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GXP74_RS09955 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GXP74_RS09960 ENOG4107EUI c reductase, iron-sulfur GXP74_RS09970 ENOG4105CCU oxidase (Subunit III) GXP74_RS09980 ENOG4108I0Q anthranilate phosphoribosyltransferase GXP74_RS09985 ENOG4105C9B Cysteine desulfurase GXP74_RS10060 ENOG4105D0U Arsenite-activated ATPase (ArsA) GXP74_RS10070 ENOG4105DKQ ROK family GXP74_RS10100 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS10105 ENOG4105CTQ phosphohexokinase GXP74_RS10125 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GXP74_RS10145 ENOG4108UQY Iron-storage protein GXP74_RS10160 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase GXP74_RS10170 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GXP74_RS10195 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GXP74_RS10215 ENOG4107VFM Dehydrogenase GXP74_RS10220 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GXP74_RS10230 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GXP74_RS10240 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GXP74_RS10260 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GXP74_RS10270 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GXP74_RS10280 ENOG4105CJN penicillin-binding protein GXP74_RS10285 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GXP74_RS10295 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GXP74_RS10300 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GXP74_RS10310 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GXP74_RS10315 ENOG4105ME9 cell division protein FtsQ GXP74_RS10320 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GXP74_RS10325 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GXP74_RS10330 ENOG4105DFA alanine racemase domain protein GXP74_RS10335 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GXP74_RS10350 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GXP74_RS10360 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GXP74_RS10400 ENOG4105C0B DNA polymerase III (alpha subunit) GXP74_RS10435 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GXP74_RS10440 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GXP74_RS10445 ENOG4105CIH Imidazole acetol-phosphate transaminase GXP74_RS10450 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GXP74_RS10460 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GXP74_RS10465 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GXP74_RS10470 ENOG4108176 endoribonuclease L-psp GXP74_RS10475 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GXP74_RS10485 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GXP74_RS10490 ENOG4105CRQ synthase (Component I) GXP74_RS10510 ENOG4105DK0 Indole-3-glycerol phosphate synthase GXP74_RS10515 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GXP74_RS10520 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GXP74_RS10540 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS10545 ENOG4105ENE Histidine kinase GXP74_RS10555 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GXP74_RS10595 ENOG4107QTZ amino acid GXP74_RS10600 ENOG4107QTZ amino acid GXP74_RS10620 ENOG4105KA0 thioesterase Superfamily protein GXP74_RS10630 ENOG4105F2W methyltransferase GXP74_RS10640 ENOG4107R13 MMPL domain protein GXP74_RS10645 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GXP74_RS10680 ENOG4105EYF MMPL domain protein GXP74_RS10695 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GXP74_RS10700 ENOG4108IY8 ABC, transporter GXP74_RS10725 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GXP74_RS10735 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GXP74_RS10740 ENOG4105CSU acyl-Coa dehydrogenase GXP74_RS10780 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GXP74_RS10805 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GXP74_RS10820 ENOG4108UW5 maltose o-acetyltransferase GXP74_RS10880 ENOG4105DWY Agmatine deiminase GXP74_RS10885 ENOG4105CQM Urea amidohydrolase subunit alpha GXP74_RS10895 ENOG4105CMR udp-glucose 4-epimerase GXP74_RS10915 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GXP74_RS10940 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXP74_RS10950 ENOG4107HP6 Transcriptional regulator GXP74_RS10955 ENOG4107R9S Malate synthase GXP74_RS10960 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GXP74_RS11020 ENOG4105C6Y Udp-glucose 6-dehydrogenase GXP74_RS11085 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GXP74_RS11115 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GXP74_RS11120 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GXP74_RS11125 ENOG41060W2 glyoxylate carboligase GXP74_RS11130 ENOG4105BZW Glycerate kinase GXP74_RS11145 ENOG4105CH6 catalase GXP74_RS11175 ENOG4105C7N Xanthine uracil vitamin C permease GXP74_RS11195 ENOG4105DGW oligopeptidase A GXP74_RS11205 ENOG4105DKQ ROK family GXP74_RS11210 ENOG4105E8R UPF0173 metal-dependent hydrolase GXP74_RS11215 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GXP74_RS11235 ENOG4108TCJ secreted hydrolase GXP74_RS11290 ENOG4105D56 permease protein GXP74_RS11295 ENOG4105EG2 ABC transporter, permease GXP74_RS11300 ENOG4105CG3 alpha amylase, catalytic region GXP74_RS11390 ENOG4108ZJ4 polysaccharide deacetylase GXP74_RS11435 ENOG4105DRR Transcriptional regulator, GntR family GXP74_RS11445 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GXP74_RS11450 ENOG4105CXT aspartate transcarbamylase GXP74_RS11455 ENOG4105CD3 dihydroorotase GXP74_RS11465 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GXP74_RS11470 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GXP74_RS11475 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GXP74_RS11480 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GXP74_RS11485 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GXP74_RS11490 ENOG4105SKN orotidine 5''-phosphate decarboxylase GXP74_RS11500 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GXP74_RS11520 ENOG41082VC UPF0145 protein GXP74_RS11535 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXP74_RS11540 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GXP74_RS11550 ENOG4105DJV ribulose-phosphate 3-epimerase GXP74_RS11595 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GXP74_RS11635 ENOG4108Z66 YbaK ebsC protein GXP74_RS11640 ENOG4105BZU Histidine kinase GXP74_RS11660 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GXP74_RS11665 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GXP74_RS11670 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GXP74_RS11675 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GXP74_RS11695 ENOG4107UAX integral membrane protein GXP74_RS11700 ENOG4108IUX (ABC) transporter GXP74_RS11710 ENOG4106F1P AAA ATPase, central domain protein GXP74_RS11720 ENOG4105XTG Pfam:DUF156 GXP74_RS11735 ENOG4105EW9 transcriptional regulator AsnC family GXP74_RS11755 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GXP74_RS11765 ENOG4105Q70 GXP74_RS11770 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GXP74_RS11810 ENOG4105DHU Bile acid GXP74_RS11815 ENOG4107653 Transcriptional regulator GXP74_RS11820 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GXP74_RS11835 ENOG4105MC2 DSBA oxidoreductase GXP74_RS11845 ENOG4105EJ2 Transcriptional regulator GXP74_RS11860 ENOG4105EX0 alpha-galactosidase GXP74_RS11870 ENOG4108Q50 Histidine kinase GXP74_RS11895 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GXP74_RS11900 ENOG4108S93 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GXP74_RS11930 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GXP74_RS11935 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GXP74_RS11940 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GXP74_RS11945 ENOG4105CQM Urea amidohydrolase subunit alpha GXP74_RS11950 ENOG4105KI2 Urea amidohydrolase subunit beta GXP74_RS11960 ENOG4108YZ9 Urea amidohydrolase subunit gamma GXP74_RS11990 ENOG4105CGK Exodeoxyribonuclease III GXP74_RS12005 ENOG4107NHD transcriptional regulator GXP74_RS12010 ENOG4105C5H ABC transporter GXP74_RS12015 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GXP74_RS12040 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GXP74_RS12090 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GXP74_RS12215 ENOG4105ETS cytosine purines uracil thiamine allantoin GXP74_RS12220 ENOG4107RR1 TRANSCRIPTIONal GXP74_RS12225 ENOG4105C26 Dehydrogenase GXP74_RS12275 ENOG4105NRA 50s ribosomal protein l31 type b GXP74_RS12280 ENOG41062A4 Transcriptional regulator GXP74_RS12285 ENOG4108YYC ycei family GXP74_RS12290 ENOG4108VCA G U mismatch-specific DNA glycosylase GXP74_RS12315 ENOG41083X2 DNA polymerase III, epsilon subunit GXP74_RS12320 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GXP74_RS12350 ENOG4105C0R drug resistance transporter emrb qaca subfamily GXP74_RS12355 ENOG41067TZ transcriptional regulator, MarR family GXP74_RS12370 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GXP74_RS12395 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GXP74_RS12400 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GXP74_RS12430 ENOG4105CGK Exodeoxyribonuclease III GXP74_RS12440 ENOG4105NPE arsR family transcriptional regulator GXP74_RS12470 ENOG4108R85 Short chain dehydrogenase GXP74_RS12495 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GXP74_RS12515 ENOG4106A3M Cytochrome p-450 GXP74_RS12550 ENOG4108SGK Tetr family transcriptional regulator GXP74_RS12555 ENOG4105C29 acyl-CoA thioesterase GXP74_RS12585 ENOG4107STQ Multicopper oxidase GXP74_RS12590 ENOG4105DY8 decarboxylase GXP74_RS12595 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GXP74_RS12605 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GXP74_RS12640 ENOG4105FDP GntR family transcriptional regulator GXP74_RS12645 ENOG4105DKQ ROK family GXP74_RS12660 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GXP74_RS12665 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GXP74_RS12670 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GXP74_RS12685 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GXP74_RS12710 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GXP74_RS12730 ENOG4105C5I Dehydrogenase GXP74_RS12735 ENOG4105CTQ phosphohexokinase GXP74_RS12750 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXP74_RS12760 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS12805 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS12860 ENOG4105DE4 1-phosphofructokinase GXP74_RS12865 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GXP74_RS12875 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GXP74_RS12880 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GXP74_RS12885 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GXP74_RS12895 ENOG4105BZ1 (ABC) transporter GXP74_RS12910 ENOG4105PGM cation diffusion facilitator family transporter GXP74_RS12915 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GXP74_RS12980 ENOG4108UB4 uncharacterized protein ygjQ GXP74_RS12985 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GXP74_RS12995 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GXP74_RS13020 ENOG4105NTW Transcriptional regulator GXP74_RS13035 ENOG4108UW5 maltose o-acetyltransferase GXP74_RS13060 ENOG4105C6T cysteine synthase GXP74_RS13070 ENOG4105MVE transcriptional regulator GXP74_RS13100 ENOG4105C3R Methionine synthase GXP74_RS13110 ENOG4105DEF Extracellular solute-binding protein, family 5 GXP74_RS13115 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS13145 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GXP74_RS13150 ENOG4105E5F proteasome GXP74_RS13155 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) GXP74_RS13165 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GXP74_RS13170 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GXP74_RS13175 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GXP74_RS13190 ENOG4108FFZ Transcriptional regulator GXP74_RS13210 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GXP74_RS13215 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GXP74_RS13270 ENOG4105D29 Helix-turn-helix type 11 domain protein GXP74_RS13305 ENOG4105E2Y ABC, transporter GXP74_RS13315 ENOG4108T5E Copper resistance protein GXP74_RS13335 ENOG4108KQ5 Integrase catalytic subunit GXP74_RS13360 ENOG4105HFS 5'-3' exonuclease GXP74_RS13365 ENOG4105CHR reductase GXP74_RS13395 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GXP74_RS13400 ENOG41084BS 50S ribosomal protein L35 GXP74_RS13405 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GXP74_RS13410 ENOG4108RWN rrna methyltransferase GXP74_RS13415 ENOG4105BZU Histidine kinase GXP74_RS13420 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GXP74_RS13425 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GXP74_RS13430 ENOG41066UM arsR family transcriptional regulator GXP74_RS13450 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GXP74_RS13465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GXP74_RS13480 ENOG4105C0B DNA polymerase III (alpha subunit) GXP74_RS13490 ENOG4105CSV Glutaminase GXP74_RS13515 ENOG4105E39 Enoyl-CoA hydratase GXP74_RS13520 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) GXP74_RS13540 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GXP74_RS13545 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GXP74_RS13585 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GXP74_RS13590 ENOG4105BZP glycoside hydrolase 15-related GXP74_RS13600 ENOG4105CPQ Dehydrogenase GXP74_RS13655 ENOG4106CKV Pap2 superfamily protein GXP74_RS13680 ENOG4105C0B DNA polymerase III (alpha subunit) GXP74_RS13705 ENOG4105C0B DNA polymerase III (alpha subunit) GXP74_RS13735 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GXP74_RS13740 ENOG4107S1E Beta-lactamase GXP74_RS13745 ENOG4107R4N Cell wall formation (By similarity) GXP74_RS13780 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GXP74_RS13835 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GXP74_RS13840 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GXP74_RS13845 ENOG4105CAS nag kinase GXP74_RS13850 ENOG4105C8Y Acetylornithine aminotransferase GXP74_RS13855 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GXP74_RS13860 ENOG4105CDH Citrulline--aspartate ligase GXP74_RS13865 ENOG4105CH7 arginosuccinase GXP74_RS13890 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GXP74_RS13895 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GXP74_RS13905 ENOG4108762 serine threonine protein kinase GXP74_RS13965 ENOG4105KF0 sporulation and cell division protein, SsgA GXP74_RS13985 ENOG4108IRC dna polymerase iii GXP74_RS14000 ENOG4105C22 threonyL-tRNA synthetase GXP74_RS14030 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase GXP74_RS14035 ENOG4105E2K Glycosyl transferase (Group 1 GXP74_RS14045 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GXP74_RS14050 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GXP74_RS14055 ENOG4105CDY transcriptional regulatory protein GXP74_RS14060 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GXP74_RS14065 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GXP74_RS14070 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GXP74_RS14080 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GXP74_RS14085 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GXP74_RS14090 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GXP74_RS14100 ENOG4105C99 atpase involved in dna repair GXP74_RS14105 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GXP74_RS14115 ENOG4105CUT histidyl-tRNA synthetase GXP74_RS14120 ENOG4105C9M aspartyl-trna synthetase GXP74_RS14135 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GXP74_RS14155 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GXP74_RS14160 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GXP74_RS14170 ENOG4105E2X shikimate dehydrogenase GXP74_RS14175 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GXP74_RS14180 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GXP74_RS14185 ENOG4105D49 3-dehydroquinate synthase GXP74_RS14190 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GXP74_RS14200 ENOG4105DC7 peptidase M24 GXP74_RS14205 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GXP74_RS14210 ENOG410803B Involved in the transcription termination process (By similarity) GXP74_RS14225 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS14235 ENOG4108IXY short-chain dehydrogenase reductase GXP74_RS14275 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS14290 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GXP74_RS14295 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GXP74_RS14335 ENOG4105DEF Extracellular solute-binding protein, family 5 GXP74_RS14340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXP74_RS14345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS14350 ENOG4105C3U ABC transporter GXP74_RS14370 ENOG4105CVK Glutamate decarboxylase GXP74_RS14375 ENOG4108JGH Tetr family transcriptional regulator GXP74_RS14385 ENOG4105EY8 ABC transporter GXP74_RS14390 ENOG4105FBD synthase GXP74_RS14410 ENOG4105EWU Squalene--hopene cyclase GXP74_RS14420 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GXP74_RS14445 ENOG4105CHR reductase GXP74_RS14450 ENOG4105D2B acyl-CoA dehydrogenase GXP74_RS14455 ENOG4105D2B acyl-CoA dehydrogenase GXP74_RS14500 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GXP74_RS14520 ENOG4108IG5 Transcriptional regulator GXP74_RS14530 ENOG4105DKQ ROK family GXP74_RS14535 ENOG4107QHQ amino acid GXP74_RS14550 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS14580 ENOG4105F95 Monooxygenase GXP74_RS14600 ENOG4105DUX Transporter GXP74_RS14605 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GXP74_RS14615 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha GXP74_RS14635 ENOG4107HP6 Transcriptional regulator GXP74_RS14655 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GXP74_RS14685 ENOG4105CPC Aldo Keto reductase GXP74_RS14690 ENOG4105DYW oxidoreductase GXP74_RS14695 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GXP74_RS14700 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GXP74_RS14725 ENOG4105WN5 stage II sporulation protein GXP74_RS14735 ENOG4107R6F Alpha Beta Hydrolase Fold protein GXP74_RS14750 ENOG41082AN stage II sporulation protein GXP74_RS14785 ENOG4105DIA mandelate racemase muconate lactonizing GXP74_RS14790 ENOG4105BZP glycoside hydrolase 15-related GXP74_RS14795 ENOG4107JEE Short-chain dehydrogenase reductase Sdr GXP74_RS14805 ENOG4105CIK Amidinotransferase GXP74_RS14820 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GXP74_RS14825 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS14870 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GXP74_RS14875 ENOG4105E39 Enoyl-CoA hydratase GXP74_RS14885 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GXP74_RS14890 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXP74_RS14900 ENOG4108JQ6 ABC transporter GXP74_RS14910 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GXP74_RS15010 ENOG4105E2R ROK family GXP74_RS15015 ENOG4105E2R ROK family GXP74_RS15035 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GXP74_RS15070 ENOG41060NJ transcriptional regulator GXP74_RS15100 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS15105 ENOG4105BZU Histidine kinase GXP74_RS15110 ENOG4105CJ1 ABC, transporter GXP74_RS15120 ENOG4108C33 Resolvase GXP74_RS15135 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GXP74_RS15160 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GXP74_RS15180 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GXP74_RS15190 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GXP74_RS15195 ENOG4105K6V RNA polymerase GXP74_RS15200 ENOG4105RNG membrane GXP74_RS15240 ENOG4105C8N cysteinyl-tRNA synthetase GXP74_RS15245 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GXP74_RS15250 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GXP74_RS15255 ENOG4105DMF Dehydrogenase GXP74_RS15265 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GXP74_RS15275 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GXP74_RS15295 ENOG4105X7H acyl-CoA dehydrogenase GXP74_RS15305 ENOG4105D94 Major Facilitator Superfamily GXP74_RS15310 ENOG4108V1U phospholipid-binding protein GXP74_RS15335 ENOG4108Z0Z intracellular protease Pfpi family GXP74_RS15350 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS15355 ENOG4105BZU Histidine kinase GXP74_RS15390 ENOG4105C83 adenylosuccinate lyase GXP74_RS15400 ENOG4105F2W methyltransferase GXP74_RS15405 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein GXP74_RS15425 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GXP74_RS15455 ENOG4106W5V Membrane GXP74_RS15475 ENOG4105CPP Dehydrogenase, E1 component GXP74_RS15480 ENOG4107R0V Pyruvate dehydrogenase GXP74_RS15500 ENOG4105J5T Amp-dependent synthetase and ligase GXP74_RS15535 ENOG4108KQJ Type 11 methyltransferase GXP74_RS15565 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GXP74_RS15630 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GXP74_RS15640 ENOG4105CV8 reductase GXP74_RS15655 ENOG4105CAQ asparagine synthetase GXP74_RS15670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GXP74_RS15675 ENOG4105BZU Histidine kinase GXP74_RS15685 ENOG4105EZR dyp-type peroxidase family protein GXP74_RS15690 ENOG4105DFF Rod shape-determining protein mreb GXP74_RS15735 ENOG4108MJI response regulator GXP74_RS15740 ENOG4107QTZ amino acid GXP74_RS15755 ENOG4105CDA abc transporter atp-binding protein GXP74_RS15760 ENOG4106PMH Extracellular solute-binding protein family 3 GXP74_RS15765 ENOG4105DRP amino acid AbC transporter GXP74_RS15785 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GXP74_RS15835 ENOG4107Y80 Major Facilitator superfamily GXP74_RS15840 ENOG4105KBX Transcriptional regulator, TetR family GXP74_RS15845 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS15865 ENOG4105D9G High-affinity GXP74_RS15885 ENOG4108Z86 Glutamine amidotransferase GXP74_RS15905 ENOG4105DIA mandelate racemase muconate lactonizing GXP74_RS15920 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GXP74_RS15925 ENOG4107QR9 Iron-sulfur cluster binding protein GXP74_RS15930 ENOG41080R8 Conserved Protein GXP74_RS15955 ENOG4105BZP glycoside hydrolase 15-related GXP74_RS15980 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GXP74_RS16010 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family GXP74_RS16015 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GXP74_RS16020 ENOG4105CAY ferredoxin--nadp reductase GXP74_RS16025 ENOG4105C57 major facilitator superfamily GXP74_RS16030 ENOG4105RJZ Transcriptional regulator GXP74_RS16040 ENOG4105C0D helicase GXP74_RS16050 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GXP74_RS16055 ENOG4106UW1 Major Facilitator superfamily GXP74_RS16095 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GXP74_RS16105 ENOG4105CVP deoxyribo-dipyrimidine photolyase GXP74_RS16145 ENOG4105HSS phospholipase C GXP74_RS16150 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) GXP74_RS16160 ENOG4105VBF alkaline shock protein GXP74_RS16165 ENOG4107SCK Monooxygenase GXP74_RS16210 ENOG4105MS9 Resuscitation-promoting factor GXP74_RS16230 ENOG4108ZJI phenylacetic acid degradation protein GXP74_RS16255 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GXP74_RS16260 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GXP74_RS16270 ENOG4105CQM Urea amidohydrolase subunit alpha GXP74_RS16280 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GXP74_RS16285 ENOG4108YZ9 Urea amidohydrolase subunit gamma GXP74_RS16295 ENOG4105E98 transcriptional regulator DeoR family GXP74_RS16305 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GXP74_RS16310 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GXP74_RS16315 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GXP74_RS16340 ENOG4105PTV Nudix Hydrolase GXP74_RS16350 ENOG4105DUM transcriptional regulator, lysR family GXP74_RS16355 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GXP74_RS16380 ENOG4105CMR udp-glucose 4-epimerase GXP74_RS16405 ENOG4107SET aldo keto reductase GXP74_RS16435 ENOG4105C1B dTDP-glucose 4-6-dehydratase GXP74_RS16465 ENOG4105E7U AraC family transcriptional regulator GXP74_RS16525 ENOG4105C84 Histidine ammonia-lyase GXP74_RS16555 ENOG4105CIR epoxide hydrolase GXP74_RS16585 ENOG4105EUZ Beta-lactamase domain protein GXP74_RS16610 ENOG4105CMT Dihydroxyacetone kinase GXP74_RS16615 ENOG4105CMT Dihydroxyacetone kinase GXP74_RS16660 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GXP74_RS16670 ENOG4105C8H hydrogenase maturation protein Hypf GXP74_RS16680 ENOG4105CQS hydrogenase expression formation protein HypD GXP74_RS16685 ENOG4105C45 hydrogenase expression formation protein (HypE) GXP74_RS16705 ENOG41067RQ csbd family GXP74_RS16720 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GXP74_RS16730 ENOG4105ETX regulatoR GXP74_RS16755 ENOG4105ECY inositol monophosphatase GXP74_RS16790 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GXP74_RS16800 ENOG4108Z6Z Transcriptional regulator GXP74_RS16810 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB GXP74_RS16820 ENOG4107SCA Formamidase (EC 3.5.1.49) GXP74_RS16825 ENOG4105CPC Aldo Keto reductase GXP74_RS16850 ENOG4105CH2 amidohydrolase GXP74_RS16855 ENOG4107RA9 decarboxylase GXP74_RS16900 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GXP74_RS16905 ENOG4107QTZ amino acid GXP74_RS16950 ENOG4105DND Transcriptional regulator GXP74_RS16960 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GXP74_RS16990 ENOG4105C7W Xanthine dehydrogenase GXP74_RS17000 ENOG4105CWX Alpha-1,2-mannosidase GXP74_RS17065 ENOG4105EGE secreted protein GXP74_RS17085 ENOG4105BZU Histidine kinase GXP74_RS17110 ENOG4108TM9 integral membrane protein GXP74_RS17115 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GXP74_RS17120 ENOG4107NHD transcriptional regulator GXP74_RS17125 ENOG4107QZF nitrite reductase NADPH large subunit GXP74_RS17135 ENOG4105DQQ Major facilitator superfamily MFS_1 GXP74_RS17170 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GXP74_RS17180 ENOG4108RU0 short-chain dehydrogenase reductase GXP74_RS17190 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GXP74_RS17195 ENOG4105BZ4 penicillin-binding protein GXP74_RS17205 ENOG4105CPC Aldo Keto reductase GXP74_RS17210 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GXP74_RS17255 ENOG4105D9U N-acetyltransferase GXP74_RS17280 ENOG4105EGE secreted protein GXP74_RS17305 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GXP74_RS17320 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GXP74_RS17330 ENOG4108PVQ transcriptional regulator GXP74_RS17350 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GXP74_RS17370 ENOG41061H0 Monooxygenase GXP74_RS17385 ENOG4105CPN adenine deaminase GXP74_RS17390 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) GXP74_RS17395 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS17425 ENOG4105DZ6 Band 7 protein GXP74_RS17480 ENOG4106A3M Cytochrome p-450 GXP74_RS17500 ENOG4105C1B dTDP-glucose 4-6-dehydratase GXP74_RS17530 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GXP74_RS17540 ENOG4105EAH synthase GXP74_RS17545 ENOG4106A3M Cytochrome p-450 GXP74_RS17570 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GXP74_RS17575 ENOG4105C0W non-ribosomal peptide synthetase GXP74_RS17580 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GXP74_RS17585 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS17680 ENOG4108W8B Beta-lactamase domain protein GXP74_RS17690 ENOG4108YIQ Alpha beta hydrolase GXP74_RS17695 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GXP74_RS17700 ENOG4105ECQ AraC Family Transcriptional Regulator GXP74_RS17705 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GXP74_RS17750 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GXP74_RS17760 ENOG41060NJ transcriptional regulator GXP74_RS17900 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GXP74_RS18025 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS18030 ENOG4105BZU Histidine kinase GXP74_RS18040 ENOG4107RN3 metallophosphoesterase GXP74_RS18045 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GXP74_RS18080 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS18100 ENOG4105C7S Dehydrogenase GXP74_RS18125 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GXP74_RS18165 ENOG4105EKQ RNA-directed DNA polymerase GXP74_RS18190 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXP74_RS18200 ENOG4107QRI Phosphoketolase GXP74_RS18220 ENOG4107QNJ CoA-transferase subunit B GXP74_RS18230 ENOG4107RSM transcriptional regulator GXP74_RS18235 ENOG4105F2C Acetyl-CoA acetyltransferase GXP74_RS18255 ENOG4105ECQ AraC Family Transcriptional Regulator GXP74_RS18270 ENOG4105EA8 2-Nitropropane dioxygenase GXP74_RS18275 ENOG4105CHR reductase GXP74_RS18285 ENOG4105D2B acyl-CoA dehydrogenase GXP74_RS18290 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS18295 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr GXP74_RS18300 ENOG4105CHR reductase GXP74_RS18330 ENOG4105CIR epoxide hydrolase GXP74_RS18370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS18375 ENOG4105C3U ABC transporter GXP74_RS18395 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GXP74_RS18415 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS18420 ENOG4107S9F NmrA family GXP74_RS18500 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GXP74_RS18505 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GXP74_RS18510 ENOG4105C7W Xanthine dehydrogenase GXP74_RS18545 ENOG4107S5I aldo keto reductase GXP74_RS18580 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GXP74_RS18590 ENOG4105CTU Proline racemase GXP74_RS18595 ENOG4105DRR Transcriptional regulator, GntR family GXP74_RS18605 ENOG4105EX0 alpha-galactosidase GXP74_RS18610 ENOG4108KXM LysR family Transcriptional regulator GXP74_RS18615 ENOG4105KXC Collagenase GXP74_RS18640 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GXP74_RS18645 ENOG41082BM Transcriptional regulator, arsr family GXP74_RS18660 ENOG4105EMU Dehydrogenase GXP74_RS18670 ENOG4105C26 Dehydrogenase GXP74_RS18685 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GXP74_RS18700 ENOG4105KVH Transcriptional regulator GXP74_RS18720 ENOG41065KQ synthase GXP74_RS18805 ENOG4105CHR reductase GXP74_RS18820 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GXP74_RS18825 ENOG4105EX0 alpha-galactosidase GXP74_RS18840 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GXP74_RS18845 ENOG4105EX0 alpha-galactosidase GXP74_RS18870 ENOG4105CYP glycoside hydrolase, family GXP74_RS18875 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS18885 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GXP74_RS18890 ENOG4105C2J ABC transporter GXP74_RS18895 ENOG4107R9N ABC transporter GXP74_RS18900 ENOG41062B0 ABC transporter, permease GXP74_RS18905 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS18910 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GXP74_RS18920 ENOG4107NHD transcriptional regulator GXP74_RS18950 ENOG4105D0M Protease HtpX homolog GXP74_RS18990 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXP74_RS19025 ENOG4105CWX Alpha-1,2-mannosidase GXP74_RS19040 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GXP74_RS19060 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase GXP74_RS19075 ENOG4105JZC GHMP kinase GXP74_RS19120 ENOG4107VAM peptidase, m28 GXP74_RS19175 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GXP74_RS19235 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GXP74_RS19245 ENOG4105FDP GntR family transcriptional regulator GXP74_RS19250 ENOG4105E33 succinate dehydrogenase GXP74_RS19265 ENOG4105C5Q Transcriptional regulator GXP74_RS19270 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) GXP74_RS19275 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS19285 ENOG4107VXZ Hydrolase GXP74_RS19340 ENOG4105F27 Major Facilitator GXP74_RS19355 ENOG4105E2D ec 3.2.1.52 GXP74_RS19420 ENOG4105KVH Transcriptional regulator GXP74_RS19425 ENOG4105ECR NmrA family GXP74_RS19430 ENOG4108ZHR arsR family transcriptional regulator GXP74_RS19450 ENOG4108JQ5 ABC transporter GXP74_RS19460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS19465 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXP74_RS19530 ENOG41090E6 transcriptional regulator MERR family GXP74_RS19535 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GXP74_RS19565 ENOG4108X0B nad(p)h dehydrogenase (quinone) GXP74_RS19570 ENOG4105WAB arsR family transcriptional regulator GXP74_RS19585 ENOG4105EXG Transcriptional regulator GXP74_RS19605 ENOG41061H0 Monooxygenase GXP74_RS19720 ENOG4105ESN nucleotide-binding protein GXP74_RS19745 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GXP74_RS19760 ENOG4105FDP GntR family transcriptional regulator GXP74_RS19785 ENOG4105VTR Integrase GXP74_RS19830 ENOG4105CYP glycoside hydrolase, family GXP74_RS19835 ENOG4105WBV Transcriptional regulator GXP74_RS19840 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GXP74_RS19845 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GXP74_RS19875 ENOG4108UHU Aldolase GXP74_RS19880 ENOG4105CXK mandelate racemase muconate lactonizing GXP74_RS19885 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GXP74_RS19890 ENOG4105CHR reductase GXP74_RS19895 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GXP74_RS19935 ENOG4107258 Transcriptional regulator GXP74_RS19945 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GXP74_RS19950 ENOG4105D56 permease protein GXP74_RS20015 ENOG4105ENE Histidine kinase GXP74_RS20080 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS20100 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS20120 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS20125 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS20135 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GXP74_RS20220 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GXP74_RS20315 ENOG4105EKT )-iron permease GXP74_RS20340 ENOG4107R1I NAD-dependent malic enzyme GXP74_RS20390 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GXP74_RS20400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GXP74_RS20440 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXP74_RS20480 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GXP74_RS20520 ENOG4105E6M Sulphatase-modifying factor protein GXP74_RS20575 ENOG4105CAT Cytidine monophosphate kinase GXP74_RS20595 ENOG4108F3G Type I restriction-modification system, R subunit GXP74_RS20620 ENOG4105F0K SARP family transcriptional regulator GXP74_RS20675 ENOG4108F3G Type I restriction-modification system, R subunit GXP74_RS20695 ENOG4105CAT Cytidine monophosphate kinase GXP74_RS20750 ENOG4105E6M Sulphatase-modifying factor protein GXP74_RS20765 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GXP74_RS20795 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GXP74_RS20835 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXP74_RS20875 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GXP74_RS20885 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GXP74_RS20935 ENOG4107R1I NAD-dependent malic enzyme GXP74_RS20960 ENOG4105EKT )-iron permease GXP74_RS21145 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GXP74_RS21230 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS21235 ENOG4105ENE Histidine kinase GXP74_RS21240 ENOG4106IBS oxygenase GXP74_RS21280 ENOG4105D56 permease protein GXP74_RS21285 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GXP74_RS21295 ENOG4107258 Transcriptional regulator GXP74_RS21335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GXP74_RS21340 ENOG4105CHR reductase GXP74_RS21345 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GXP74_RS21350 ENOG4105CXK mandelate racemase muconate lactonizing GXP74_RS21355 ENOG4108UHU Aldolase GXP74_RS21385 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GXP74_RS21390 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GXP74_RS21395 ENOG4105WBV Transcriptional regulator GXP74_RS21400 ENOG4105CYP glycoside hydrolase, family GXP74_RS21445 ENOG4105VTR Integrase GXP74_RS21470 ENOG4105FDP GntR family transcriptional regulator GXP74_RS21485 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GXP74_RS21510 ENOG4105ESN nucleotide-binding protein GXP74_RS21625 ENOG41061H0 Monooxygenase GXP74_RS21645 ENOG4105EXG Transcriptional regulator GXP74_RS21660 ENOG4105WAB arsR family transcriptional regulator GXP74_RS21665 ENOG4108X0B nad(p)h dehydrogenase (quinone) GXP74_RS21695 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GXP74_RS21700 ENOG41090E6 transcriptional regulator MERR family GXP74_RS21765 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXP74_RS21770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS21780 ENOG4108JQ5 ABC transporter GXP74_RS21800 ENOG4108ZHR arsR family transcriptional regulator GXP74_RS21805 ENOG4105ECR NmrA family GXP74_RS21810 ENOG4105KVH Transcriptional regulator GXP74_RS21840 ENOG4105CYP glycoside hydrolase, family GXP74_RS21915 ENOG4105DC1 bifunctional purine biosynthesis protein purh GXP74_RS21930 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GXP74_RS21955 ENOG4105EP9 oxidoreductase GXP74_RS21960 ENOG4105U5Y Transcriptional regulator GXP74_RS21965 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GXP74_RS21985 ENOG4106FKC arabinogalactan endo-1,4-beta-galactosidase GXP74_RS21995 ENOG4108RAV Conserved protein GXP74_RS22015 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GXP74_RS22020 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GXP74_RS22025 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GXP74_RS22045 ENOG4105KVH Transcriptional regulator GXP74_RS22050 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GXP74_RS22070 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GXP74_RS22080 ENOG4108JPW Aminotransferase GXP74_RS22085 ENOG4105EUJ GTP cyclohydrolase i GXP74_RS22095 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GXP74_RS22100 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GXP74_RS22105 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GXP74_RS22125 ENOG4108RYK Nad-dependent epimerase dehydratase GXP74_RS22155 ENOG4105CHP RNA polymerase GXP74_RS22185 ENOG4108R85 Short chain dehydrogenase GXP74_RS22215 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXP74_RS22225 ENOG41067RQ csbd family GXP74_RS22285 ENOG4107MMM Anti-sigma-factor antagonist GXP74_RS22290 ENOG4105FUA antagonist GXP74_RS22295 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GXP74_RS22305 ENOG4105BZU Histidine kinase GXP74_RS22335 ENOG4105JZI cytochrome P450 GXP74_RS22340 ENOG4107QVI Methyltransferase, type 11 GXP74_RS22350 ENOG4105DVW rieske (2Fe-2S) GXP74_RS22365 ENOG4105CMR udp-glucose 4-epimerase GXP74_RS22390 ENOG4105CGD Nad-dependent epimerase dehydratase GXP74_RS22415 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXP74_RS22440 ENOG4105BZU Histidine kinase GXP74_RS22455 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXP74_RS22460 ENOG4105C54 Major Facilitator superfamily GXP74_RS22495 ENOG4105CHR reductase GXP74_RS22510 ENOG4105EEM helicase GXP74_RS22520 ENOG4107QRI Phosphoketolase GXP74_RS22530 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GXP74_RS22550 ENOG41085A6 mbth domain-containing protein GXP74_RS22595 ENOG41061H0 Monooxygenase GXP74_RS22600 ENOG4105WQT MbtH domain protein GXP74_RS22715 ENOG4105D9R oxidoreductase GXP74_RS22720 ENOG41090KN UPF0303 protein GXP74_RS22790 ENOG4106A3M Cytochrome p-450 GXP74_RS22890 ENOG4107VIJ nudix hydrolase GXP74_RS22900 ENOG4105E98 transcriptional regulator DeoR family GXP74_RS22945 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GXP74_RS22950 ENOG4105C7K acetolactate synthase GXP74_RS22955 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS22980 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GXP74_RS22995 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GXP74_RS23000 ENOG4105CFG Acts as a chaperone (By similarity) GXP74_RS23005 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GXP74_RS23030 ENOG4108RWI nicotinamidase GXP74_RS23045 ENOG4105CNA YD repeat protein GXP74_RS23065 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GXP74_RS23070 ENOG4107S1Q Phosphatase GXP74_RS23160 ENOG4108NNZ chitinase GXP74_RS23165 ENOG4105BZ1 (ABC) transporter GXP74_RS23205 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GXP74_RS23210 ENOG4107RCI amp-dependent synthetase and ligase GXP74_RS23230 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GXP74_RS23250 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS23290 ENOG4108SGK Tetr family transcriptional regulator GXP74_RS23300 ENOG4105ETS cytosine purines uracil thiamine allantoin GXP74_RS23330 ENOG4105DCG PHP domain protein GXP74_RS23350 ENOG4105FDF Could be involved in DNA repair (By similarity) GXP74_RS23355 ENOG4105DQE DNA ligase GXP74_RS23360 ENOG4105DQE DNA ligase GXP74_RS23405 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GXP74_RS23410 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GXP74_RS23430 ENOG4105CJ1 ABC, transporter GXP74_RS23445 ENOG4107UBR Extracellular solute-binding protein family 3 GXP74_RS23450 ENOG4105EAD ABC transporter GXP74_RS23515 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GXP74_RS23545 ENOG4105D1K glutamate--cysteine ligase GXP74_RS23555 ENOG4108V75 Glutamine amidotransferase GXP74_RS23570 ENOG4108Z9K Osmotically inducible protein GXP74_RS23590 ENOG4107QX3 carboxylase GXP74_RS23600 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GXP74_RS23615 ENOG4105NAU thioesterase Superfamily protein GXP74_RS23740 ENOG4105ECQ AraC Family Transcriptional Regulator GXP74_RS23745 ENOG41090B9 response to stress GXP74_RS23755 ENOG4105ETS cytosine purines uracil thiamine allantoin GXP74_RS23760 ENOG4105EFZ amidohydrolase GXP74_RS23770 ENOG4105C31 Tryptophanyl-tRNA synthetase GXP74_RS23775 ENOG4105DDN Pentapeptide repeat-containing protein GXP74_RS23785 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GXP74_RS23800 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GXP74_RS23820 ENOG4105XPP Protein of unknown function (DUF1275) GXP74_RS23830 ENOG4108UZX fmn reductase GXP74_RS23835 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GXP74_RS23845 ENOG4107R5B glutamine synthetase GXP74_RS23850 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GXP74_RS23855 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GXP74_RS23865 ENOG4105EMU Dehydrogenase GXP74_RS23880 ENOG4105QNJ serralysin (EC 3.4.24.40) GXP74_RS23885 ENOG4105EMU Dehydrogenase GXP74_RS23900 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GXP74_RS23925 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GXP74_RS23930 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GXP74_RS23945 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GXP74_RS23950 ENOG4108K8U Glycerol operon regulatory protein GXP74_RS23955 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GXP74_RS23960 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GXP74_RS23965 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GXP74_RS23975 ENOG4108TCJ secreted hydrolase GXP74_RS24005 ENOG4105E7W lamb ycsf family protein GXP74_RS24010 ENOG4105P4J Allophanate hydrolase, subunit 1 GXP74_RS24015 ENOG4107R7A Allophanate hydrolase subunit 2 GXP74_RS24025 ENOG4108MJN Glycosyl Transferase GXP74_RS24075 ENOG4105E39 Enoyl-CoA hydratase GXP74_RS24105 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS24120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXP74_RS24125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS24130 ENOG4105C3U ABC transporter GXP74_RS24140 ENOG4108ZHJ Organic hydroperoxide resistance protein GXP74_RS24145 ENOG4105K56 Transcriptional regulator GXP74_RS24155 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GXP74_RS24160 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit GXP74_RS24165 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GXP74_RS24170 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GXP74_RS24175 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GXP74_RS24180 ENOG4105CSW GntR family transcriptional regulator GXP74_RS24240 ENOG4108IND Tetr family transcriptional regulator GXP74_RS24265 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS24270 ENOG4105BZU Histidine kinase GXP74_RS24275 ENOG4105P52 geranylgeranyl reductase GXP74_RS24300 ENOG4105C10 Electron transfer flavoprotein GXP74_RS24320 ENOG4105E9Q Acyl-transferase GXP74_RS24345 ENOG4105EYH Exonuclease GXP74_RS24350 ENOG4105CG3 alpha amylase, catalytic region GXP74_RS24365 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GXP74_RS24370 ENOG4105E4C Lytic transglycosylase catalytic GXP74_RS24375 ENOG4107QP8 phosphohexose isomerase GXP74_RS24380 ENOG4105BZU Histidine kinase GXP74_RS24385 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS24390 ENOG4105C1J atp-dependent rna helicase GXP74_RS24405 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS24430 ENOG4105JHE Major Facilitator Superfamily GXP74_RS24445 ENOG4105CUB amino acid GXP74_RS24460 ENOG4105FBN Acid phosphatase GXP74_RS24465 ENOG4105DKW ABC transporter GXP74_RS24480 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS24520 ENOG4105C8T Leucyl-tRNA synthetase GXP74_RS24525 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GXP74_RS24540 ENOG4105CSR polyphosphate kinase 2 GXP74_RS24550 ENOG4105F8D glycoside hydrolase family 4 GXP74_RS24560 ENOG4105C3U ABC transporter GXP74_RS24590 ENOG4105CG3 alpha amylase, catalytic region GXP74_RS24600 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GXP74_RS24605 ENOG4105BZ7 extracellular solute-binding protein family 1 GXP74_RS24640 ENOG4107YZX Universal stress protein GXP74_RS24645 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GXP74_RS24660 ENOG4107PP3 Acetylornithine deacetylase GXP74_RS24705 ENOG4105CPQ Dehydrogenase GXP74_RS24725 ENOG41080V3 Major Facilitator superfamily GXP74_RS24740 ENOG4108UHU Aldolase GXP74_RS24755 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GXP74_RS24770 ENOG4105UA4 acetyltransferase GXP74_RS24780 ENOG4105CPQ Dehydrogenase GXP74_RS24785 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GXP74_RS24790 ENOG4106NZI LysR family Transcriptional regulator GXP74_RS24800 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GXP74_RS24805 ENOG4105NPE arsR family transcriptional regulator GXP74_RS24815 ENOG4108QDA dioxygenase GXP74_RS24870 ENOG41082SX arsR family transcriptional regulator GXP74_RS24875 ENOG4107TB5 TRANSCRIPTIONal GXP74_RS24900 ENOG4105DQ4 alcohol dehydrogenase GXP74_RS24905 ENOG4108S01 response regulator GXP74_RS24995 ENOG4108RNG Permease of the drug metabolite transporter GXP74_RS25025 ENOG4105C22 threonyL-tRNA synthetase GXP74_RS25030 ENOG41066UM arsR family transcriptional regulator GXP74_RS25035 ENOG4107QYR Signal peptidase i GXP74_RS25045 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GXP74_RS25050 ENOG4105JAB phenazine biosynthesis protein, phzf family GXP74_RS25060 ENOG4106UDK Cellulose-binding, family II GXP74_RS25075 ENOG4105EGE secreted protein GXP74_RS25090 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GXP74_RS25100 ENOG4107S5I aldo keto reductase GXP74_RS25105 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GXP74_RS25115 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GXP74_RS25200 ENOG4106R7G Glycoside hydrolase family 5 GXP74_RS25205 ENOG41065HY 1,4-beta-cellobiosidase GXP74_RS25220 ENOG4105CHR reductase GXP74_RS25250 ENOG4105VEQ Cold shock protein GXP74_RS25255 ENOG4105MS9 Resuscitation-promoting factor GXP74_RS25270 ENOG4105DIH basic membrane GXP74_RS25275 ENOG4108JQ9 ABC transporter GXP74_RS25280 ENOG4105UIB (ABC) transporter GXP74_RS25305 ENOG4105DHJ ABC, transporter GXP74_RS25370 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GXP74_RS25405 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GXP74_RS25425 ENOG4105DBE peroxidase GXP74_RS25465 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GXP74_RS25485 ENOG4105VEQ Cold shock protein GXP74_RS25490 ENOG4105C9U ATP-dependent DNA helicase RecQ GXP74_RS25505 ENOG4105E5D amino acid GXP74_RS25510 ENOG4105CHU acetyl-coa acetyltransferase GXP74_RS25515 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GXP74_RS25530 ENOG4105KT7 mgtC SapB transporter GXP74_RS25560 ENOG4105C0R drug resistance transporter emrb qaca subfamily GXP74_RS25565 ENOG4105D3W isochorismatase GXP74_RS25580 ENOG4105D3W isochorismatase GXP74_RS25605 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GXP74_RS25615 ENOG4105E9K Isocitrate dehydrogenase GXP74_RS25635 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GXP74_RS25665 ENOG4107QZ7 Cellulose synthase catalytic subunit GXP74_RS25670 ENOG4105EXC Acyl-transferase GXP74_RS25680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GXP74_RS25715 ENOG4108ZGX Histidine kinase GXP74_RS25720 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS25730 ENOG4105EYF MMPL domain protein GXP74_RS25735 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS25740 ENOG4105DKQ ROK family GXP74_RS25745 ENOG4105FDP GntR family transcriptional regulator GXP74_RS25775 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GXP74_RS25820 ENOG4105XEA Tetr family transcriptional regulator GXP74_RS25845 ENOG4107EEY synthase GXP74_RS25855 ENOG4108JA1 polyketide synthase GXP74_RS25875 ENOG4105DEF Extracellular solute-binding protein, family 5 GXP74_RS25885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS25915 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS25925 ENOG4105CI2 imidazolone-5-propionate hydrolase GXP74_RS25935 ENOG4105EW9 transcriptional regulator AsnC family GXP74_RS25950 ENOG4105EYF MMPL domain protein GXP74_RS25955 ENOG4108IG5 Transcriptional regulator GXP74_RS25965 ENOG4105D74 hydrolase GXP74_RS25980 ENOG4108JGH Tetr family transcriptional regulator GXP74_RS25990 ENOG4105CWX Alpha-1,2-mannosidase GXP74_RS26020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GXP74_RS26030 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GXP74_RS26095 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GXP74_RS26110 ENOG4108Z4U Ferredoxin GXP74_RS26115 ENOG4105D0M Protease HtpX homolog GXP74_RS26150 ENOG4105C0R drug resistance transporter emrb qaca subfamily GXP74_RS26160 ENOG4106NZI LysR family Transcriptional regulator GXP74_RS26205 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GXP74_RS26225 ENOG4105C3R Methionine synthase GXP74_RS26240 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS26245 ENOG4105BZU Histidine kinase GXP74_RS26270 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS26290 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GXP74_RS26295 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS26310 ENOG4107TXC Transcriptional regulator GXP74_RS26315 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) GXP74_RS26320 ENOG4105DKQ ROK family GXP74_RS26325 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GXP74_RS26330 ENOG4108JQ7 (ABC) transporter GXP74_RS26335 ENOG4105C3U ABC transporter GXP74_RS26355 ENOG4105I82 acetyl xylan esterase GXP74_RS26365 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GXP74_RS26370 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS26385 ENOG4108VQT Alpha beta hydrolase fold protein GXP74_RS26405 ENOG41082JN Transcriptional regulator GXP74_RS26430 ENOG4105DJI Methylaspartate mutase, E subunit GXP74_RS26435 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GXP74_RS26440 ENOG4105DQU oxidoreductase, subunit beta GXP74_RS26465 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GXP74_RS26470 ENOG4107QM2 Aldo Keto reductase GXP74_RS26480 ENOG4108U3T pfkb domain protein GXP74_RS26510 ENOG4108YUY GXP74_RS26515 ENOG4108PVU Nucleotidyl transferase GXP74_RS26540 ENOG4105CJ1 ABC, transporter GXP74_RS26550 ENOG4105W06 Cupin 2, conserved barrel domain protein GXP74_RS26560 ENOG4105CG3 alpha amylase, catalytic region GXP74_RS26630 ENOG4105F0K SARP family transcriptional regulator GXP74_RS26635 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GXP74_RS26640 ENOG4105I82 acetyl xylan esterase GXP74_RS26650 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS26660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXP74_RS26665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS26670 ENOG4105C3U ABC transporter GXP74_RS26705 ENOG4107W19 lmbE family GXP74_RS26715 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GXP74_RS26765 ENOG4108JPW Aminotransferase GXP74_RS26770 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GXP74_RS26785 ENOG4105C0W non-ribosomal peptide synthetase GXP74_RS26790 ENOG4108XET gCN5-related N-acetyltransferase GXP74_RS26800 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GXP74_RS26825 ENOG41061AU MarR family Transcriptional regulator GXP74_RS26840 ENOG4105ZXU NLP P60 protein GXP74_RS26855 ENOG4105CCI Myosin-Cross-Reactive Antigen GXP74_RS26860 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS26870 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GXP74_RS26890 ENOG4108KB0 deacetylase GXP74_RS26900 ENOG4105EP9 oxidoreductase GXP74_RS26920 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GXP74_RS26930 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GXP74_RS26935 ENOG4105EWK phytoene GXP74_RS26940 ENOG4108PA7 Methyltransferase GXP74_RS26950 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) GXP74_RS26960 ENOG4105C26 Dehydrogenase GXP74_RS26965 ENOG4105I9Z UPF0264 protein GXP74_RS26995 ENOG4108IQI permease GXP74_RS27005 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GXP74_RS27015 ENOG4107T3P ABC, transporter GXP74_RS27025 ENOG41066F8 ROK family GXP74_RS27040 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS27060 ENOG4105BZW Glycerate kinase GXP74_RS27075 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GXP74_RS27080 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GXP74_RS27085 ENOG4105MWK D-amino acid dehydrogenase, small subunit GXP74_RS27090 ENOG4105CPF Cell wall formation (By similarity) GXP74_RS27130 ENOG4105DNP FAD linked oxidase domain protein GXP74_RS27135 ENOG4105CIK Amidinotransferase GXP74_RS27145 ENOG4105CHJ isochorismatase hydrolase GXP74_RS27180 ENOG4105CHR reductase GXP74_RS27195 ENOG4105C12 Phosphoribosylglycinamide synthetase GXP74_RS27205 ENOG4105E2R ROK family GXP74_RS27220 ENOG4105C5I Dehydrogenase GXP74_RS27235 ENOG4105DRS transport system, permease GXP74_RS27290 ENOG4107R5R arsenical pump membrane protein GXP74_RS27310 ENOG4107QWR cellulase (EC 3.2.1.4) GXP74_RS27330 ENOG4105EDW glycosyl transferase, family 39 GXP74_RS27350 ENOG4105CH6 catalase GXP74_RS27360 ENOG4105EF1 ribulokinase GXP74_RS27370 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) GXP74_RS27375 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS27385 ENOG4105C2J ABC transporter GXP74_RS27390 ENOG4105CNN ABC, transporter GXP74_RS27425 ENOG4105QE3 oxidoreductase GXP74_RS27435 ENOG4105E2D ec 3.2.1.52 GXP74_RS27490 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS27500 ENOG4108TCJ secreted hydrolase GXP74_RS27505 ENOG4105BZ4 penicillin-binding protein GXP74_RS27520 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GXP74_RS27565 ENOG4105C19 ABC transporter GXP74_RS27585 ENOG4105CPF Cell wall formation (By similarity) GXP74_RS27590 ENOG4105CPF Cell wall formation (By similarity) GXP74_RS27610 ENOG4105CNN ABC, transporter GXP74_RS27615 ENOG4105C2J ABC transporter GXP74_RS27620 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS27665 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS27695 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS27700 ENOG4105BZU Histidine kinase GXP74_RS27710 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GXP74_RS27725 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS27750 ENOG4107RSM transcriptional regulator GXP74_RS27755 ENOG4105CAQ asparagine synthetase GXP74_RS27765 ENOG4105CD3 dihydroorotase GXP74_RS27785 ENOG4105BZU Histidine kinase GXP74_RS27790 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS27850 ENOG4105BZU Histidine kinase GXP74_RS27870 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS27885 ENOG4108S8N class II Aldolase GXP74_RS27900 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS27930 ENOG4107QQG Dehydrogenase GXP74_RS27935 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GXP74_RS28005 ENOG4105CMR udp-glucose 4-epimerase GXP74_RS28010 ENOG4107TYG Oxidoreductase domain-containing protein GXP74_RS28015 ENOG4105D3Q Sugar transferase GXP74_RS28035 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GXP74_RS28040 ENOG4105H3G oxidoreductase GXP74_RS28050 ENOG4105C26 Dehydrogenase GXP74_RS28070 ENOG4105KME endoribonuclease L-psp GXP74_RS28080 ENOG4105CBC glutamate synthase GXP74_RS28090 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GXP74_RS28105 ENOG4105E2Z phosphate ABC transporter (Permease GXP74_RS28195 ENOG41061GT Aldolase GXP74_RS28200 ENOG4106M32 3-dehydroquinate synthase GXP74_RS28205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GXP74_RS28210 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS28235 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GXP74_RS28240 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GXP74_RS28270 ENOG4105E8G Major facilitator Superfamily GXP74_RS28290 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GXP74_RS28295 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GXP74_RS28345 ENOG4108JA1 polyketide synthase GXP74_RS28380 ENOG4105C57 major facilitator superfamily GXP74_RS28385 ENOG4105C0R drug resistance transporter emrb qaca subfamily GXP74_RS28425 ENOG4108ZXC Two component transcriptional regulator, luxr family GXP74_RS28435 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GXP74_RS28450 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXP74_RS28475 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GXP74_RS28495 ENOG4105CXY transporter GXP74_RS28520 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GXP74_RS28525 ENOG4108KPJ rna polymerase sigma factor GXP74_RS28540 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXP74_RS28580 ENOG4105DQ5 transport system permease protein GXP74_RS28585 ENOG4105TVJ transport system, permease GXP74_RS28590 ENOG4105E0A ABC, transporter GXP74_RS28610 ENOG4105ECR NmrA family GXP74_RS28635 ENOG4105VEQ Cold shock protein GXP74_RS28645 ENOG4108K6T Protein of unknown function (DUF1205) GXP74_RS28655 ENOG4105CIK Amidinotransferase GXP74_RS28675 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS28690 ENOG4106A3M Cytochrome p-450 GXP74_RS28745 ENOG41079KZ Major Facilitator Superfamily GXP74_RS28755 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXP74_RS28805 ENOG4106UDK Cellulose-binding, family II GXP74_RS28825 ENOG41064E2 Xylose isomerase-like TIM barrel GXP74_RS28840 ENOG4108YUY GXP74_RS28845 ENOG4108KK4 3-dehydroquinate synthase GXP74_RS28855 ENOG4105F27 Major Facilitator GXP74_RS28895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS28905 ENOG4105EUZ Beta-lactamase domain protein GXP74_RS28910 ENOG4105MGM doxx family GXP74_RS28915 ENOG4105ECB domain protein GXP74_RS28965 ENOG4105DRS transport system, permease GXP74_RS28970 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GXP74_RS28980 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS29000 ENOG4105HSS phospholipase C GXP74_RS29010 ENOG4105C12 Phosphoribosylglycinamide synthetase GXP74_RS29015 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GXP74_RS29020 ENOG4105DBV ornithine carbamoyltransferase GXP74_RS29025 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS29030 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS29040 ENOG4105CIF Ornithine Cyclodeaminase GXP74_RS29065 ENOG4105E2R ROK family GXP74_RS29085 ENOG4108KPJ rna polymerase sigma factor GXP74_RS29090 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GXP74_RS29100 ENOG4105F0K SARP family transcriptional regulator GXP74_RS29115 ENOG4105D01 (LipO)protein GXP74_RS29125 ENOG4108UMI ABC transporter, permease GXP74_RS29130 ENOG4105CAY ferredoxin--nadp reductase GXP74_RS29140 ENOG4105JZI cytochrome P450 GXP74_RS29150 ENOG4105ETX regulatoR GXP74_RS29155 ENOG4105I8F Histidine kinase GXP74_RS29165 ENOG4107S1E Beta-lactamase GXP74_RS29190 ENOG4105C8Y Acetylornithine aminotransferase GXP74_RS29215 ENOG4106UDK Cellulose-binding, family II GXP74_RS29250 ENOG410834F Transcriptional regulator GXP74_RS29325 ENOG4107UB2 Alpha beta hydrolase fold GXP74_RS29330 ENOG4105CHR reductase GXP74_RS29415 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GXP74_RS29425 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS29495 ENOG4107S5I aldo keto reductase GXP74_RS29500 ENOG4107RSM transcriptional regulator GXP74_RS29510 ENOG4105CPC Aldo Keto reductase GXP74_RS29515 ENOG4105YIP Tetr family transcriptional regulator GXP74_RS29520 ENOG4105CIR epoxide hydrolase GXP74_RS29550 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GXP74_RS29565 ENOG4108S01 response regulator GXP74_RS29570 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS29580 ENOG4105DBV ornithine carbamoyltransferase GXP74_RS29590 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS29595 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS29690 ENOG4107MMM Anti-sigma-factor antagonist GXP74_RS29695 ENOG4105FUA antagonist GXP74_RS29700 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GXP74_RS29740 ENOG41085A6 mbth domain-containing protein GXP74_RS29755 ENOG4105C6T cysteine synthase GXP74_RS29805 ENOG4105CIH Imidazole acetol-phosphate transaminase GXP74_RS29825 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GXP74_RS29840 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GXP74_RS29860 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GXP74_RS29990 ENOG4105C29 acyl-CoA thioesterase GXP74_RS30005 ENOG4105MS9 Resuscitation-promoting factor GXP74_RS30030 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GXP74_RS30035 ENOG4105CAT Cytidine monophosphate kinase GXP74_RS30045 ENOG4105T38 integral membrane protein GXP74_RS30075 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GXP74_RS30110 ENOG4105FE9 pseudouridine synthase GXP74_RS30115 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GXP74_RS30120 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GXP74_RS30135 ENOG4105DCF alanine dehydrogenase GXP74_RS30145 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GXP74_RS30150 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GXP74_RS30155 ENOG4105BZP glycoside hydrolase 15-related GXP74_RS30160 ENOG4107VXZ Hydrolase GXP74_RS30165 ENOG4107QPH glycogen) synthase GXP74_RS30170 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GXP74_RS30175 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GXP74_RS30200 ENOG4105DSU hydrolase GXP74_RS30240 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GXP74_RS30250 ENOG4108VX5 3-methyladenine DNA glycosylase GXP74_RS30255 ENOG4108V1U phospholipid-binding protein GXP74_RS30270 ENOG410842T Pterin carbinolamine dehydratase GXP74_RS30290 ENOG4105DKW ABC transporter GXP74_RS30300 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS30305 ENOG4105ENE Histidine kinase GXP74_RS30310 ENOG4105BZU Histidine kinase GXP74_RS30315 ENOG4105IDI abc transporter atp-binding protein GXP74_RS30320 ENOG4105EAC phosphoserine phosphatase GXP74_RS30335 ENOG4107YCY Transcriptional regulator GXP74_RS30355 ENOG4105CHR reductase GXP74_RS30385 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXP74_RS30395 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GXP74_RS30400 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS30410 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GXP74_RS30420 ENOG4105BZP glycoside hydrolase 15-related GXP74_RS30445 ENOG4105VBF alkaline shock protein GXP74_RS30465 ENOG4105C5H ABC transporter GXP74_RS30500 ENOG4105CJR Integral membrane protein (MviN GXP74_RS30510 ENOG4105D3Q Sugar transferase GXP74_RS30515 ENOG4105CPK Glycosyl transferase (Group 1 GXP74_RS30530 ENOG4105PTV Nudix Hydrolase GXP74_RS30565 ENOG4105C1G acyl-Coa dehydrogenase GXP74_RS30570 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme GXP74_RS30580 ENOG4105C57 major facilitator superfamily GXP74_RS30605 ENOG4105C5F glutamine synthetase GXP74_RS30620 ENOG4105CJP fad dependent oxidoreductase GXP74_RS30635 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GXP74_RS30640 ENOG4105CTK cobaltochelatase, cobn subunit GXP74_RS30655 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GXP74_RS30670 ENOG4107BJW polysaccharide deacetylase GXP74_RS30675 ENOG4105K64 Glycosyl transferase, family 2 GXP74_RS30715 ENOG4106WTF Glycosyl transferase, family 2 GXP74_RS30740 ENOG4105E4R Precorrin-3B C17-methyltransferase GXP74_RS30745 ENOG41081F0 Precorrin-8x methylmutase GXP74_RS30785 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GXP74_RS30820 ENOG4105E9Z Nad-dependent epimerase dehydratase GXP74_RS30825 ENOG4106FN3 tellurium resistance protein GXP74_RS30870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS30905 ENOG4105C26 Dehydrogenase GXP74_RS30945 ENOG4105VG1 fes assembly suf system protein GXP74_RS30950 ENOG4108UNV SUF system FeS assembly protein, NifU family GXP74_RS30955 ENOG4105C9B Cysteine desulfurase GXP74_RS30960 ENOG4105C3K feS assembly ATPase SufC GXP74_RS30970 ENOG4105JRK feS assembly protein SufD GXP74_RS30995 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GXP74_RS31025 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GXP74_RS31030 ENOG4105CV1 Transketolase (EC 2.2.1.1) GXP74_RS31035 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GXP74_RS31050 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) GXP74_RS31075 ENOG4105E6M Sulphatase-modifying factor protein GXP74_RS31080 ENOG4105CMR udp-glucose 4-epimerase GXP74_RS31095 ENOG4105CP7 Triose-phosphate isomerase GXP74_RS31100 ENOG4105BZA Phosphoglycerate kinase GXP74_RS31105 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GXP74_RS31110 ENOG4105CIE May be required for sporulation (By similarity) GXP74_RS31120 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GXP74_RS31125 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GXP74_RS31150 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GXP74_RS31160 ENOG4105C5X domain protein GXP74_RS31185 ENOG4105VEQ Cold shock protein GXP74_RS31200 ENOG4105VEQ Cold shock protein GXP74_RS31205 ENOG4105VEQ Cold shock protein GXP74_RS31215 ENOG4106NZI LysR family Transcriptional regulator GXP74_RS31220 ENOG4105C0R drug resistance transporter emrb qaca subfamily GXP74_RS31245 ENOG4105DU1 integral membrane protein, terc GXP74_RS31255 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GXP74_RS31275 ENOG4105DFU Cell wall formation (By similarity) GXP74_RS31280 ENOG4105E0X reductase GXP74_RS31295 ENOG4108762 serine threonine protein kinase GXP74_RS31305 ENOG4107JTW chlorite dismutase GXP74_RS31310 ENOG4105C1Q protoporphyrinogen oxidase GXP74_RS31320 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GXP74_RS31340 ENOG4105CHU acetyl-coa acetyltransferase GXP74_RS31345 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GXP74_RS31350 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) GXP74_RS31370 ENOG4108HWW ABC transporter GXP74_RS31375 ENOG4105C2J ABC transporter GXP74_RS31380 ENOG4105DFW ABC transporter GXP74_RS31385 ENOG4105E2R ROK family GXP74_RS31400 ENOG4107QM5 aconitate hydratase GXP74_RS31410 ENOG4105DBV ornithine carbamoyltransferase GXP74_RS31430 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GXP74_RS31470 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GXP74_RS31475 ENOG4105C0X amino acid GXP74_RS31480 ENOG4107VEG TrkA-N domain protein GXP74_RS31505 ENOG4105DV0 amidase (EC 3.5.1.4 GXP74_RS31580 ENOG4105C2M dna polymerase I GXP74_RS31645 ENOG4105K7W phage-related replication protein GXP74_RS31765 ENOG4105GVF (ABC) transporter GXP74_RS31770 ENOG4105E2B Taurine dioxygenase GXP74_RS31775 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GXP74_RS31780 ENOG4105E2Y ABC, transporter GXP74_RS31790 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GXP74_RS31820 ENOG4106F60 Histidine kinase GXP74_RS31825 ENOG4105F44 Two component transcriptional regulator, winged helix family GXP74_RS31840 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GXP74_RS31865 ENOG4105KHC sulfurtransferase GXP74_RS31885 ENOG4105CD5 CoA-binding domain protein GXP74_RS31890 ENOG410849S phosphocarrier protein (HPr) GXP74_RS31895 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GXP74_RS31925 ENOG4105F95 Monooxygenase GXP74_RS31960 ENOG4105E0Y RtcB Protein GXP74_RS31995 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXP74_RS32015 ENOG4107QN1 sodium solute GXP74_RS32025 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS32030 ENOG4105BZU Histidine kinase GXP74_RS32040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXP74_RS32055 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXP74_RS32070 ENOG4108IJ6 ABC transporter GXP74_RS32085 ENOG4105C9U ATP-dependent DNA helicase RecQ GXP74_RS32100 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GXP74_RS32115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GXP74_RS32125 ENOG4105KVH Transcriptional regulator GXP74_RS32135 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GXP74_RS32140 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GXP74_RS32145 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GXP74_RS32180 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GXP74_RS32185 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GXP74_RS32190 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GXP74_RS32200 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GXP74_RS32215 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GXP74_RS32240 ENOG4105EB3 Histidine kinase GXP74_RS32245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXP74_RS32250 ENOG4105CDA abc transporter atp-binding protein GXP74_RS32270 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GXP74_RS32275 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GXP74_RS32280 ENOG4105KC9 Modulates RecA activity (By similarity) GXP74_RS32285 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GXP74_RS32305 ENOG4106AXJ AraC family transcriptional regulator GXP74_RS32325 ENOG4107QRT dEAD DEAH box helicase GXP74_RS32335 ENOG4105WBV Transcriptional regulator GXP74_RS32340 ENOG4105CEV competence damage-inducible protein GXP74_RS32350 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GXP74_RS32360 ENOG4107QZI cell division protein FtsK GXP74_RS32365 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GXP74_RS32390 ENOG4105DKK Benzoate GXP74_RS32410 ENOG4105CN5 Metallo-Beta-Lactamase GXP74_RS32415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GXP74_RS32435 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GXP74_RS32440 ENOG4105C1V Peptidase, M16 GXP74_RS32445 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GXP74_RS32450 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GXP74_RS32460 ENOG4105EC2 ftsk spoIIIe GXP74_RS32530 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GXP74_RS32535 ENOG4105SFS phosphoesterase RecJ domain protein GXP74_RS32540 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GXP74_RS32565 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GXP74_RS32580 ENOG4105BZU Histidine kinase GXP74_RS32595 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GXP74_RS32605 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GXP74_RS32615 ENOG4105C26 Dehydrogenase GXP74_RS32630 ENOG4108JPW Aminotransferase GXP74_RS32660 ENOG4105J7D transcriptional regulator GXP74_RS32665 ENOG4105C26 Dehydrogenase GXP74_RS32675 ENOG4105CJP fad dependent oxidoreductase GXP74_RS32700 ENOG4105C26 Dehydrogenase GXP74_RS32710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GXP74_RS32715 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GXP74_RS32725 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GXP74_RS32730 ENOG4105KNE Phosphatidate cytidylyltransferase GXP74_RS32735 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GXP74_RS32740 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GXP74_RS32745 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GXP74_RS32750 ENOG4105CE9 30S ribosomal protein S2 GXP74_RS32765 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXP74_RS32780 ENOG41080R2 UPF0102 protein GXP74_RS32790 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GXP74_RS32805 ENOG4107QYR Signal peptidase i GXP74_RS32815 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GXP74_RS32820 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GXP74_RS32825 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GXP74_RS32830 ENOG41082KU UPF0109 protein GXP74_RS32835 ENOG4105K5M 30s ribosomal protein S16 GXP74_RS32845 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) GXP74_RS32855 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GXP74_RS32860 ENOG4105D9U N-acetyltransferase GXP74_RS32870 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GXP74_RS32900 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GXP74_RS32910 ENOG4108375 Acylphosphatase (EC 3.6.1.7) GXP74_RS32920 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GXP74_RS32925 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GXP74_RS32930 ENOG41084BZ 50S ribosomal protein L32 GXP74_RS32945 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GXP74_RS32950 ENOG4106H78 methyltransferase GXP74_RS32965 ENOG4105DP4 dak2 domain fusion protein ylov GXP74_RS32970 ENOG4105VB9 50S ribosomal protein l28 GXP74_RS32975 ENOG4105DWF phosphomethylpyrimidine kinase GXP74_RS32980 ENOG4105CTQ phosphohexokinase GXP74_RS33005 ENOG4105CPF Cell wall formation (By similarity) GXP74_RS33010 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GXP74_RS33030 ENOG4105K70 DNA-binding protein GXP74_RS33040 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GXP74_RS33045 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GXP74_RS33050 ENOG41069M3 Transcriptional regulator GXP74_RS33100 ENOG4105ERH Fumarylacetoacetate hydrolase GXP74_RS33115 ENOG4105GWZ Roadblock lc7 family protein GXP74_RS33135 ENOG4105GWZ Roadblock lc7 family protein GXP74_RS33150 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GXP74_RS33160 ENOG4105CM2 brancheD-chain amino acid aminotransferase GXP74_RS33165 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GXP74_RS33175 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GXP74_RS33185 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin GXP74_RS33200 ENOG4108JQ1 Dehydrogenase GXP74_RS33205 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GXP74_RS33210 ENOG4108ZP8 Acetolactate synthase small subunit GXP74_RS33230 ENOG4107SM8 Adenylate Guanylate cyclase GXP74_RS33245 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GXP74_RS33255 ENOG41090JH (ATPase)-like protein GXP74_RS33265 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GXP74_RS33270 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GXP74_RS33275 ENOG4105BZU Histidine kinase GXP74_RS33280 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GXP74_RS33305 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GXP74_RS33315 ENOG4107HP6 Transcriptional regulator GXP74_RS33320 ENOG4105EN6 Membrane GXP74_RS33325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS33330 ENOG4108J59 Extracellular solute-binding protein, family 5 GXP74_RS33340 ENOG4105C3U ABC transporter GXP74_RS33345 ENOG4108JQ7 (ABC) transporter GXP74_RS33360 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GXP74_RS33365 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GXP74_RS33370 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GXP74_RS33375 ENOG4105EJQ L-serine dehydratase GXP74_RS33400 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GXP74_RS33410 ENOG4105C57 major facilitator superfamily GXP74_RS33435 ENOG4105ZXU NLP P60 protein GXP74_RS33460 ENOG4105ID8 Transcriptional regulator, ARAC family GXP74_RS33490 ENOG4108V1U phospholipid-binding protein GXP74_RS33520 ENOG4105CPN adenine deaminase GXP74_RS33535 ENOG410901P UPF0249 protein GXP74_RS33540 ENOG4107TB5 TRANSCRIPTIONal GXP74_RS33555 ENOG4105CMQ Chloride channel GXP74_RS33585 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GXP74_RS33590 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GXP74_RS33625 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GXP74_RS33650 ENOG4105BZ1 (ABC) transporter GXP74_RS33655 ENOG4105BZ1 (ABC) transporter GXP74_RS33700 ENOG4107TB5 TRANSCRIPTIONal GXP74_RS33705 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GXP74_RS33710 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GXP74_RS33720 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GXP74_RS33725 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GXP74_RS33745 ENOG4105C6K Malic enzyme GXP74_RS33750 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GXP74_RS33825 ENOG4105CHU acetyl-coa acetyltransferase GXP74_RS33845 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GXP74_RS33850 ENOG4105CJ1 ABC, transporter GXP74_RS33860 ENOG4105CJ1 ABC, transporter GXP74_RS33885 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GXP74_RS33905 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GXP74_RS33920 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GXP74_RS33925 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GXP74_RS33930 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GXP74_RS33935 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GXP74_RS33940 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GXP74_RS33945 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GXP74_RS33950 ENOG4105ZA1 atp synthase GXP74_RS33960 ENOG4105Z3P ATP synthase GXP74_RS33965 ENOG4105ESV Glycosyl transferase, family 4 GXP74_RS33970 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GXP74_RS33975 ENOG4107ZF2 Phosphatase GXP74_RS33985 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GXP74_RS33990 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GXP74_RS33995 ENOG4105VFB Binds the 23S rRNA (By similarity) GXP74_RS34010 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GXP74_RS34015 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GXP74_RS34020 ENOG4105D6E homoserine dehydrogenase GXP74_RS34025 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GXP74_RS34030 ENOG4105C75 arginyL-tRNA synthetase GXP74_RS34035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GXP74_RS34055 ENOG4105CVR type I restriction-modification system GXP74_RS34100 ENOG4105DRR Transcriptional regulator, GntR family GXP74_RS34135 ENOG4105ERH Fumarylacetoacetate hydrolase GXP74_RS34140 ENOG4105D9U N-acetyltransferase GXP74_RS34250 ENOG4105CMG Carbohydrate kinase GXP74_RS34290 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GXP74_RS34335 ENOG4108PYU two-component system response regulator GXP74_RS34340 ENOG4105EB3 Histidine kinase GXP74_RS34345 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GXP74_RS34375 ENOG4105CB2 alcohol dehydrogenase GXP74_RS34380 ENOG4105C6K Malic enzyme GXP74_RS34395 ENOG4108VEQ Superoxide dismutase GXP74_RS34430 ENOG4105CBD Diacylglycerol kinase GXP74_RS34450 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GXP74_RS34460 ENOG4105D17 glycoside hydrolase, family 3 domain protein GXP74_RS34480 ENOG4105FDP GntR family transcriptional regulator GXP74_RS34500 ENOG4105C26 Dehydrogenase GXP74_RS34505 ENOG4105C26 Dehydrogenase GXP74_RS34510 ENOG4105NAF rna polymerase sigma factor GXP74_RS34515 ENOG4108KXV response regulator GXP74_RS34520 ENOG41065SU Two-component system sensor kinase GXP74_RS34545 ENOG4107RSM transcriptional regulator GXP74_RS34550 ENOG4105D94 Major Facilitator Superfamily GXP74_RS34565 ENOG4107RM1 amidohydrolase GXP74_RS34610 ENOG4105DZ1 carboxypeptidase GXP74_RS34625 ENOG4108TAG Histidine kinase GXP74_RS34635 ENOG4107H3J ribonuclease GXP74_RS34640 ENOG4107SJB teichoic acid biosynthesis GXP74_RS34640 ENOG4107SJB teichoic acid biosynthesis GXP74_RS34645 ENOG4107SJB teichoic acid biosynthesis GXP74_RS34650 ENOG4107SJB teichoic acid biosynthesis GXP74_RS34665 ENOG4105C31 Tryptophanyl-tRNA synthetase GXP74_RS34680 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GXP74_RS34685 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GXP74_RS34705 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GXP74_RS34715 ENOG4105W8D rdd domain containing protein GXP74_RS34720 ENOG4105DC1 bifunctional purine biosynthesis protein purh GXP74_RS34750 ENOG4105CMV Succinyl-CoA synthetase subunit beta GXP74_RS34760 ENOG4105IQ5 FAD linked oxidase domain protein GXP74_RS34775 ENOG4105DEG Vwa containing coxe family protein GXP74_RS34785 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GXP74_RS34815 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) GXP74_RS34820 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS34855 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GXP74_RS34860 ENOG4106D2I Chorismate mutase GXP74_RS34875 ENOG4105C26 Dehydrogenase GXP74_RS34885 ENOG4107QN2 dihydrolipoyl dehydrogenase GXP74_RS34890 ENOG4105D9P serine threonine protein kinase GXP74_RS34900 ENOG4105D9P serine threonine protein kinase GXP74_RS34905 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GXP74_RS34915 ENOG4107QVP Dehydrogenase GXP74_RS34925 ENOG4108MMM RNA Polymerase GXP74_RS34930 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS34935 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXP74_RS34950 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GXP74_RS34965 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GXP74_RS34970 ENOG410801F ribosomal-protein-alanine acetyltransferase GXP74_RS34990 ENOG4108097 ATP-binding protein GXP74_RS34995 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 GXP74_RS35000 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GXP74_RS35035 ENOG4105CS9 pantothenic acid kinase GXP74_RS35040 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GXP74_RS35045 ENOG4108UJD 30S ribosomal protein S9 GXP74_RS35050 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GXP74_RS35055 ENOG4105C5H ABC transporter GXP74_RS35065 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GXP74_RS35070 ENOG4108ZT0 50S ribosomal protein l17 GXP74_RS35075 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GXP74_RS35080 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GXP74_RS35085 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GXP74_RS35090 ENOG41067V7 50S ribosomal protein L36 GXP74_RS35095 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GXP74_RS35105 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GXP74_RS35110 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GXP74_RS35115 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GXP74_RS35125 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GXP74_RS35130 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GXP74_RS35135 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GXP74_RS35140 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GXP74_RS35145 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GXP74_RS35150 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GXP74_RS35155 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GXP74_RS35160 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GXP74_RS35165 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GXP74_RS35170 ENOG41082SA 50s ribosomal protein l29 GXP74_RS35175 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GXP74_RS35180 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GXP74_RS35185 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GXP74_RS35190 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GXP74_RS35195 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GXP74_RS35205 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GXP74_RS35210 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GXP74_RS35215 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GXP74_RS35245 ENOG4108PBI Polysaccharide metabolism GXP74_RS35255 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GXP74_RS35280 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GXP74_RS35285 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GXP74_RS35310 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GXP74_RS35315 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GXP74_RS35325 ENOG4108VZM 50s ribosomal protein L10 GXP74_RS35330 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GXP74_RS35335 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GXP74_RS35340 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GXP74_RS35360 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GXP74_RS35365 ENOG4107R4N Cell wall formation (By similarity) GXP74_RS35385 ENOG410900P UPF0336 protein GXP74_RS35390 ENOG4105WDJ 50S ribosomal protein L33 GXP74_RS35425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXP74_RS35440 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GXP74_RS35465 ENOG4108VPT UPF0234 protein GXP74_RS35490 ENOG4108UVJ appr-1-p processing domain protein GXP74_RS35510 ENOG4108JQ1 Dehydrogenase GXP74_RS35520 ENOG4107SVH Potassium channel protein GXP74_RS35525 ENOG4105D0M Protease HtpX homolog GXP74_RS35530 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS35535 ENOG4105C8S subunit m GXP74_RS35540 ENOG4105D65 subunit l GXP74_RS35545 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS35555 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS35560 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GXP74_RS35565 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GXP74_RS35570 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS35575 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GXP74_RS35605 ENOG4105FBW Monooxygenase GXP74_RS35615 ENOG4105C0H protease GXP74_RS35665 ENOG4105BZU Histidine kinase GXP74_RS35670 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GXP74_RS35675 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GXP74_RS35680 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GXP74_RS35685 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GXP74_RS35690 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GXP74_RS35710 ENOG4108IG5 Transcriptional regulator GXP74_RS35715 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GXP74_RS35720 ENOG4108ZT1 Transcriptional regulator GXP74_RS35730 ENOG4105CRK lysyL-tRNA synthetase GXP74_RS35740 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS35745 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GXP74_RS35775 ENOG4105CSH Transporter GXP74_RS35795 ENOG4105C5H ABC transporter GXP74_RS35800 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GXP74_RS35805 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GXP74_RS35815 ENOG4105F8V Hydrolase, tatD family GXP74_RS35820 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GXP74_RS35845 ENOG4105CJN penicillin-binding protein GXP74_RS35850 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GXP74_RS35860 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS35865 ENOG4105BZU Histidine kinase GXP74_RS35870 ENOG4108RVA ribokinase GXP74_RS35880 ENOG4107QHZ cell cycle protein GXP74_RS35925 ENOG4105F27 Major Facilitator GXP74_RS35940 ENOG4105EMN RNA polymerase sigma factor GXP74_RS36080 ENOG4105D9U N-acetyltransferase GXP74_RS36085 ENOG4108RIR Molybdenum cofactor biosynthesis protein GXP74_RS36090 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXP74_RS36100 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GXP74_RS36110 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GXP74_RS36140 ENOG4105EDW glycosyl transferase, family 39 GXP74_RS36150 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS36170 ENOG4108762 serine threonine protein kinase GXP74_RS36175 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GXP74_RS36180 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GXP74_RS36190 ENOG4105D2B acyl-CoA dehydrogenase GXP74_RS36200 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXP74_RS36215 ENOG4108ZHR arsR family transcriptional regulator GXP74_RS36220 ENOG4108SQ9 flavin reductase domain protein, FMN-binding GXP74_RS36245 ENOG4105MXW flavin reductase domain protein, FMN-binding GXP74_RS36260 ENOG41081HM 2'-5' rna ligase GXP74_RS36270 ENOG4105E8G Major facilitator Superfamily GXP74_RS36280 ENOG4105C7N Xanthine uracil vitamin C permease GXP74_RS36290 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GXP74_RS36300 ENOG4105CRE cytochrome C GXP74_RS36305 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) GXP74_RS36310 ENOG4107QIV Cytochrome c biogenesis protein GXP74_RS36315 ENOG4107ZT5 Thiol disulfide interchange protein GXP74_RS36320 ENOG4108RH7 phosphoglycerate mutase GXP74_RS36325 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GXP74_RS36335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXP74_RS36465 ENOG4105D9P serine threonine protein kinase GXP74_RS36565 ENOG4105D52 delta-aminolevulinic acid dehydratase GXP74_RS36570 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GXP74_RS36575 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GXP74_RS36580 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GXP74_RS36585 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GXP74_RS36630 ENOG4108XFF GXP74_RS36635 ENOG4105DGU Histone deacetylase GXP74_RS36650 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GXP74_RS36655 ENOG4105II7 pyrroline-5-carboxylate reductase GXP74_RS36675 ENOG4105C01 Dihydroxy-acid dehydratase GXP74_RS36680 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GXP74_RS36685 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GXP74_RS36690 ENOG4107R33 ppx gppa phosphatase GXP74_RS36705 ENOG4108JWX GXP74_RS36720 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GXP74_RS36735 ENOG4107XI7 Tetr family transcriptional regulator GXP74_RS36740 ENOG4105C26 Dehydrogenase GXP74_RS36805 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GXP74_RS36815 ENOG4108IYU L-aspartate oxidase GXP74_RS36820 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GXP74_RS36825 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GXP74_RS36835 ENOG4105CEY Amp-dependent synthetase and ligase GXP74_RS36845 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS36850 ENOG4105BZU Histidine kinase GXP74_RS36860 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXP74_RS36870 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GXP74_RS36900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GXP74_RS36905 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GXP74_RS36920 ENOG4105C0H protease GXP74_RS36935 ENOG41066UM arsR family transcriptional regulator GXP74_RS36955 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GXP74_RS36995 ENOG4105NAF rna polymerase sigma factor GXP74_RS37025 ENOG4108Z0R Transferase GXP74_RS37030 ENOG4107YBY Hydrolase GXP74_RS37050 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GXP74_RS37060 ENOG4105BZU Histidine kinase GXP74_RS37065 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS37090 ENOG4105EYF MMPL domain protein GXP74_RS37100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GXP74_RS37115 ENOG4105BZU Histidine kinase GXP74_RS37165 ENOG4108YIQ Alpha beta hydrolase GXP74_RS37185 ENOG4105E7U AraC family transcriptional regulator GXP74_RS37195 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXP74_RS37220 ENOG4105DZR Type I site-specific deoxyribonuclease GXP74_RS37235 ENOG4105CVR type I restriction-modification system GXP74_RS37275 ENOG4105C2N RNA methyltransferase TrmH family group 3 GXP74_RS37280 ENOG4105C8N cysteinyl-tRNA synthetase GXP74_RS37285 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GXP74_RS37290 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GXP74_RS37295 ENOG4108VJ1 Transcriptional regulator (CarD family GXP74_RS37305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXP74_RS37310 ENOG4105BZU Histidine kinase GXP74_RS37325 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GXP74_RS37335 ENOG4105HHS UPF0256 protein GXP74_RS37345 ENOG41067SE Tetr family transcriptional regulator GXP74_RS37370 ENOG4105D4M Lactamase_B GXP74_RS37375 ENOG4108RWI nicotinamidase GXP74_RS37385 ENOG4107XEY Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GXP74_RS37410 ENOG4105VMP Transcriptional regulator GXP74_RS37450 ENOG4108MIC Mg-protoporphyrin IX methyl transferase GXP74_RS37455 ENOG4105CI2 imidazolone-5-propionate hydrolase GXP74_RS37470 ENOG4105C5Z peptidase GXP74_RS37510 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS37515 ENOG4108ZGX Histidine kinase GXP74_RS37525 ENOG4105KVH Transcriptional regulator GXP74_RS37625 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GXP74_RS37645 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GXP74_RS37650 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GXP74_RS37660 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GXP74_RS37675 ENOG4105PKJ carbohydrate binding GXP74_RS37680 ENOG4105KHC sulfurtransferase GXP74_RS37705 ENOG4107NHD transcriptional regulator GXP74_RS37710 ENOG4105ETE Transcriptional regulator (LacI family GXP74_RS37715 ENOG4105C0H protease GXP74_RS37720 ENOG4105ETX regulatoR GXP74_RS37730 ENOG4105E5T Major Facilitator Superfamily GXP74_RS37735 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GXP74_RS37740 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GXP74_RS37755 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GXP74_RS37770 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GXP74_RS37775 ENOG4105CJ3 phosphate transporter GXP74_RS37785 ENOG4105VPX protein, conserved in bacteria GXP74_RS37805 ENOG4105DNP FAD linked oxidase domain protein GXP74_RS37810 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GXP74_RS37815 ENOG4105K4H Nlp p60 protein GXP74_RS37890 ENOG4105ESP cell wall surface anchor family protein GXP74_RS37895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXP74_RS37905 ENOG4105E1F short-chain dehydrogenase reductase GXP74_RS37935 ENOG4105D5U fad dependent oxidoreductase GXP74_RS37940 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GXP74_RS37975 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GXP74_RS37995 ENOG4105BZU Histidine kinase GXP74_RS38000 ENOG4105GWZ Roadblock lc7 family protein GXP74_RS38015 ENOG4105E90 ABC transporter GXP74_RS38020 ENOG4105E90 ABC transporter GXP74_RS38025 ENOG4108IJ8 ABC transporter GXP74_RS38030 ENOG4107TB5 TRANSCRIPTIONal GXP74_RS38040 ENOG4105RNG membrane GXP74_RS38045 ENOG4105K6V RNA polymerase GXP74_RS38065 ENOG4105NHS Transcriptional regulator, TraR DksA family GXP74_RS38070 ENOG4105VEQ Cold shock protein GXP74_RS38135 ENOG4105KAF membrAne GXP74_RS38255 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GXP74_RS38270 ENOG4105VTR Integrase GXP74_RS38325 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) GXP74_RS38335 ENOG4106A3M Cytochrome p-450 GXP74_RS38385 ENOG4108M15 ABC transporter GXP74_RS38430 ENOG4105F8J Adenylate Guanylate cyclase GXP74_RS38445 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXP74_RS38465 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS38475 ENOG41064MX Tetr family transcriptional regulator GXP74_RS38485 ENOG4108IG5 Transcriptional regulator GXP74_RS38495 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS38500 ENOG4105C1J atp-dependent rna helicase GXP74_RS38560 ENOG4107ZR7 Membrane GXP74_RS38570 ENOG4106F60 Histidine kinase GXP74_RS38575 ENOG4105F44 Two component transcriptional regulator, winged helix family GXP74_RS38595 ENOG410630P Transcriptional regulator GXP74_RS38600 ENOG41083YR Protein CrcB homolog GXP74_RS38605 ENOG41083TI Protein CrcB homolog GXP74_RS38625 ENOG4108TAC GXP74_RS38640 ENOG4105CXB phosphoribosylaminoimidazole synthetase GXP74_RS38660 ENOG4105F6U Short-chain dehydrogenase reductase Sdr GXP74_RS38665 ENOG4108KPJ rna polymerase sigma factor GXP74_RS38670 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GXP74_RS38675 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GXP74_RS38680 ENOG410839H phosphoribosylformylglycinamidine synthase GXP74_RS38700 ENOG4105C8V SAICAR synthetase GXP74_RS38715 ENOG4105C12 Phosphoribosylglycinamide synthetase GXP74_RS38730 ENOG4105DRR Transcriptional regulator, GntR family GXP74_RS38735 ENOG4108JPW Aminotransferase GXP74_RS38760 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXP74_RS38775 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GXP74_RS38790 ENOG4107RCW fructose-bisphosphate aldolase GXP74_RS38795 ENOG4105DQR SNARE associated Golgi GXP74_RS38800 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GXP74_RS38815 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GXP74_RS38835 ENOG4105E0A ABC, transporter GXP74_RS38900 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GXP74_RS38905 ENOG4108762 serine threonine protein kinase GXP74_RS38935 ENOG4105DFM M18 family aminopeptidase GXP74_RS38940 ENOG4105CSU acyl-Coa dehydrogenase GXP74_RS38950 ENOG4105EUB pirin domain protein GXP74_RS39000 ENOG4108RK3 acyl-Coa dehydrogenase GXP74_RS39005 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GXP74_RS39015 ENOG4105CVM Molybdenum cofactor synthesis domain protein GXP74_RS39025 ENOG4108KGH TRANSCRIPTIONal GXP74_RS39060 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GXP74_RS39085 ENOG4105C57 major facilitator superfamily GXP74_RS39115 ENOG4107QPV Serine Threonine protein kinase GXP74_RS39140 ENOG4105CPP Dehydrogenase, E1 component GXP74_RS39145 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GXP74_RS39175 ENOG4108UTZ Dihydroxyacetone kinase GXP74_RS39180 ENOG4105CMT Dihydroxyacetone kinase GXP74_RS39185 ENOG4105VDH Dihydroxyacetone kinase GXP74_RS39190 ENOG4105KNI merR family transcriptional Regulator GXP74_RS39195 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GXP74_RS39200 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GXP74_RS39205 ENOG4105CFG Acts as a chaperone (By similarity) GXP74_RS39210 ENOG4105DF6 Fe-S oxidoreductase GXP74_RS39220 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GXP74_RS39225 ENOG4105DHP deoxycytidine triphosphate deaminase GXP74_RS39305 ENOG4105ECR NmrA family GXP74_RS39340 ENOG4105F6S Spore photoproduct lyase GXP74_RS39365 ENOG4107SET aldo keto reductase GXP74_RS39385 ENOG4105MXW flavin reductase domain protein, FMN-binding GXP74_RS39395 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS39400 ENOG4105BZU Histidine kinase GXP74_RS39445 ENOG4105KVH Transcriptional regulator GXP74_RS39525 ENOG4105WH1 Two component transcriptional regulator luxr family GXP74_RS39530 ENOG4105BZU Histidine kinase GXP74_RS39535 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GXP74_RS39590 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GXP74_RS39625 ENOG4105CJ1 ABC, transporter GXP74_RS39630 ENOG4106F60 Histidine kinase GXP74_RS39635 ENOG4105F44 Two component transcriptional regulator, winged helix family GXP74_RS39660 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GXP74_RS39745 ENOG4105CDU Replicative dna helicase GXP74_RS39750 ENOG4107QI1 Mate efflux family protein GXP74_RS39760 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GXP74_RS39765 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GXP74_RS39770 ENOG4107YH6 single-stranded DNA-binding protein GXP74_RS39775 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GXP74_RS39800 ENOG4108JQC penicillin-binding protein 1A GXP74_RS39810 ENOG4105CZA synthase GXP74_RS39820 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GXP74_RS39835 ENOG4105D9P serine threonine protein kinase GXP74_RS39850 ENOG4105C3M thioredoxin reductase GXP74_RS39855 ENOG4105K63 Thioredoxin GXP74_RS39860 ENOG4108E1C hydrolase GXP74_RS39875 ENOG4107QJE Chromosome Partitioning Protein GXP74_RS39880 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GXP74_RS39890 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GXP74_RS39895 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GXP74_RS39905 ENOG41084CH 50S ribosomal protein l34