locus-tag	class	description
GXP74_RS00010	COG0592	DNA-directed DNA polymerase activity
GXP74_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GXP74_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GXP74_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GXP74_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GXP74_RS00095	COG0457	Tetratricopeptide repeat
GXP74_RS00095	COG0705	Rhomboid family
GXP74_RS00115	COG3764	Sortase (surface protein transpeptidase)
GXP74_RS00120	COG3764	Sortase (surface protein transpeptidase)
GXP74_RS00130	COG0515	serine threonine protein kinase
GXP74_RS00150	COG1716	ATPase activity
GXP74_RS00155	COG1716	ATPase activity
GXP74_RS00155	COG1716	ATPase activity
GXP74_RS00170	COG1942	4-Oxalocrotonate Tautomerase
GXP74_RS00175	COG2409	Drug exporters of the RND superfamily
GXP74_RS00185	COG2208	phosphoserine phosphatase activity
GXP74_RS00195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GXP74_RS00200	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS00225	COG1522	sequence-specific DNA binding
GXP74_RS00230	COG1309	transcriptional regulator
GXP74_RS00235	COG0477	Major facilitator Superfamily
GXP74_RS00250	COG0531	amino acid
GXP74_RS00260	COG3842	ATPase activity
GXP74_RS00265	COG1176	ABC-type spermidine putrescine transport system, permease component I
GXP74_RS00270	COG1177	transmembrane transport
GXP74_RS00280	COG2814	Major facilitator Superfamily
GXP74_RS00285	COG1902	pentaerythritol trinitrate reductase activity
GXP74_RS00290	COG0789	Transcriptional regulator
GXP74_RS00295	COG3118	belongs to the thioredoxin family
GXP74_RS00295	COG0492	ferredoxin-NADP+ reductase activity
GXP74_RS00310	COG1950	PFAM Membrane protein of
GXP74_RS00315	COG0662	Cupin 2, conserved barrel domain protein
GXP74_RS00320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GXP74_RS00330	COG2268	Band 7 protein
GXP74_RS00350	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GXP74_RS00385	COG1609	Transcriptional regulator
GXP74_RS00390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GXP74_RS00400	COG0577	efflux transmembrane transporter activity
GXP74_RS00400	COG1136	(ABC) transporter
GXP74_RS00415	COG4591	ABC-type transport system involved in lipoprotein release permease component
GXP74_RS00415	COG1136	(ABC) transporter
GXP74_RS00420	COG0577	efflux transmembrane transporter activity
GXP74_RS00420	COG1136	(ABC) transporter
GXP74_RS00430	COG0745	RESPONSE REGULATOR receiver
GXP74_RS00435	COG2205	protein histidine kinase activity
GXP74_RS00440	COG1271	oxidase subunit
GXP74_RS00445	COG1294	oxidase, subunit
GXP74_RS00455	COG0561	phosphatase activity
GXP74_RS00525	COG1131	(ABC) transporter
GXP74_RS00550	COG2186	Transcriptional regulator
GXP74_RS00555	COG0561	phosphatase activity
GXP74_RS00560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GXP74_RS00565	COG0077	Prephenate dehydratase
GXP74_RS00570	COG2837	iron assimilation
GXP74_RS00610	COG0006	proline dipeptidase activity
GXP74_RS00630	COG0653	protein targeting
GXP74_RS00650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXP74_RS00720	COG1857	crispr-associated protein
GXP74_RS00735	COG1518	maintenance of DNA repeat elements
GXP74_RS00740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GXP74_RS00770	COG1793	dna ligase
GXP74_RS00785	COG1940	carbohydrate kinase activity
GXP74_RS00800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GXP74_RS00805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GXP74_RS00885	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS00890	COG2204	response regulator
GXP74_RS00930	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS00980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXP74_RS00985	COG4948	Mandelate Racemase Muconate Lactonizing
GXP74_RS00995	COG2365	Tyrosine phosphatase family
GXP74_RS01000	COG1191	sigma factor activity
GXP74_RS01005	COG1191	sigma factor activity
GXP74_RS01025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXP74_RS01030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXP74_RS01075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GXP74_RS01095	COG0598	Magnesium transport protein CorA
GXP74_RS01105	COG1940	carbohydrate kinase activity
GXP74_RS01120	COG2268	Band 7 protein
GXP74_RS01140	COG1472	Belongs to the glycosyl hydrolase 3 family
GXP74_RS01185	COG0667	Aldo Keto reductase
GXP74_RS01225	COG0667	Aldo Keto reductase
GXP74_RS01230	COG4221	oxidoreductase activity
GXP74_RS01295	COG1309	transcriptional regulator
GXP74_RS01300	COG2409	Drug exporters of the RND superfamily
GXP74_RS01305	COG1280	lysine exporter protein (LysE YggA)
GXP74_RS01325	COG1309	transcriptional regulator
GXP74_RS01340	COG1131	(ABC) transporter
GXP74_RS01350	COG4585	Histidine kinase
GXP74_RS01355	COG2197	response regulator
GXP74_RS01375	COG3634	alkyl hydroperoxide reductase activity
GXP74_RS01490	COG0187	DNA topoisomerase II activity
GXP74_RS01555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GXP74_RS01560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GXP74_RS01580	COG1247	-acetyltransferase
GXP74_RS01585	COG0640	Transcriptional regulator
GXP74_RS01730	COG0525	valine-tRNA ligase activity
GXP74_RS01735	COG0438	transferase activity, transferring glycosyl groups
GXP74_RS01735	COG1216	Glycosyl transferase, family 2
GXP74_RS01760	COG1660	Displays ATPase and GTPase activities
GXP74_RS01805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GXP74_RS01810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GXP74_RS01825	COG1595	DNA-templated transcription, initiation
GXP74_RS01865	COG0667	Aldo Keto reductase
GXP74_RS01885	COG1408	metallophosphoesterase
GXP74_RS01895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXP74_RS01905	COG0003	Pfam Anion-transporting ATPase
GXP74_RS01930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXP74_RS01980	COG2267	carboxylic ester hydrolase activity
GXP74_RS01985	COG4977	sequence-specific DNA binding
GXP74_RS02020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GXP74_RS02035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GXP74_RS02085	COG3629	intracellular signal transduction
GXP74_RS02085	COG3903	Transcriptional regulator
GXP74_RS02135	COG0529	Catalyzes the synthesis of activated sulfate
GXP74_RS02150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GXP74_RS02165	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS02170	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS02195	COG0066	3-isopropylmalate dehydratase activity
GXP74_RS02200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GXP74_RS02205	COG0494	nUDIX hydrolase
GXP74_RS02230	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS02240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS02250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GXP74_RS02320	COG0596	Alpha beta hydrolase
GXP74_RS02330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GXP74_RS02335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXP74_RS02395	COG1205	dead DEAH box helicase
GXP74_RS02395	COG1111	helicase
GXP74_RS02400	COG1366	Belongs to the anti-sigma-factor antagonist family
GXP74_RS02405	COG2172	sigma factor antagonist activity
GXP74_RS02410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GXP74_RS02420	COG2890	protein-(glutamine-N5) methyltransferase activity
GXP74_RS02430	COG1754	DNA topoisomerase type I activity
GXP74_RS02430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GXP74_RS02435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GXP74_RS02440	COG0470	DNA polymerase III
GXP74_RS02515	COG2197	response regulator
GXP74_RS02680	COG0602	queuosine metabolic process
GXP74_RS02685	COG0302	gtp cyclohydrolase
GXP74_RS02700	COG0529	Catalyzes the synthesis of activated sulfate
GXP74_RS02720	COG1051	belongs to the nudix hydrolase family
GXP74_RS02905	COG0305	Participates in initiation and elongation during chromosome replication
GXP74_RS03010	COG2223	nitrite transmembrane transporter activity
GXP74_RS03020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GXP74_RS03020	COG2146	nitrite reductase [NAD(P)H] activity
GXP74_RS03025	COG0745	RESPONSE REGULATOR receiver
GXP74_RS03030	COG0243	molybdopterin cofactor binding
GXP74_RS03040	COG3189	MarR family transcriptional regulator
GXP74_RS03055	COG1846	Transcriptional regulator
GXP74_RS03070	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS03075	COG0402	S-adenosylhomocysteine deaminase activity
GXP74_RS03085	COG2124	cytochrome p450
GXP74_RS03120	COG0667	Aldo Keto reductase
GXP74_RS03125	COG3629	intracellular signal transduction
GXP74_RS03135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXP74_RS03170	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GXP74_RS03210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GXP74_RS03215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GXP74_RS03225	COG1024	Enoyl-CoA hydratase
GXP74_RS03260	COG1132	(ABC) transporter
GXP74_RS03265	COG1132	(ABC) transporter
GXP74_RS03270	COG0072	phenylalanine-tRNA ligase activity
GXP74_RS03275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GXP74_RS03280	COG2226	methyltransferase
GXP74_RS03285	COG3959	Transketolase, thiamine diphosphate binding domain
GXP74_RS03290	COG3958	Transketolase
GXP74_RS03305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXP74_RS03305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GXP74_RS03310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS03330	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS03340	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS03350	COG0673	inositol 2-dehydrogenase activity
GXP74_RS03365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS03370	COG1131	(ABC) transporter
GXP74_RS03375	COG0842	Transport permease protein
GXP74_RS03385	COG0017	Asparaginyl-tRNA synthetase
GXP74_RS03395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GXP74_RS03405	COG1136	(ABC) transporter
GXP74_RS03410	COG3795	YCII-related domain
GXP74_RS03415	COG4941	Belongs to the sigma-70 factor family
GXP74_RS03440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GXP74_RS03445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GXP74_RS03450	COG1121	(ABC) transporter
GXP74_RS03480	COG1609	Transcriptional regulator
GXP74_RS03485	COG1295	ribonuclease BN
GXP74_RS03495	COG1609	Transcriptional regulator
GXP74_RS03505	COG2814	Major facilitator Superfamily
GXP74_RS03510	COG1309	transcriptional regulator
GXP74_RS03525	COG2124	cytochrome p450
GXP74_RS03530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GXP74_RS03530	COG1672	PFAM Archaeal ATPase
GXP74_RS03535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GXP74_RS03555	COG0672	)-iron permease
GXP74_RS03600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GXP74_RS03605	COG2027	D-alanyl-D-alanine carboxypeptidase
GXP74_RS03615	COG0037	tRNA processing
GXP74_RS03630	COG0302	gtp cyclohydrolase
GXP74_RS03645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GXP74_RS03645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GXP74_RS03650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GXP74_RS03660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GXP74_RS03665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GXP74_RS03690	COG1522	sequence-specific DNA binding
GXP74_RS03700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GXP74_RS03710	COG0456	acetyltransferase
GXP74_RS03720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GXP74_RS03730	COG3300	MHYT domain
GXP74_RS03730	COG5001	Diguanylate cyclase
GXP74_RS03760	COG0395	ABC-type sugar transport system, permease component
GXP74_RS03785	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GXP74_RS03790	COG0463	Glycosyl transferase, family 2
GXP74_RS03840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GXP74_RS03845	COG3973	AAA domain
GXP74_RS03860	COG1061	Type III restriction enzyme res subunit
GXP74_RS03865	COG0181	hydroxymethylbilane synthase activity
GXP74_RS03895	COG1278	Cold shock
GXP74_RS03900	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GXP74_RS03905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GXP74_RS03915	COG2814	Major facilitator Superfamily
GXP74_RS03955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GXP74_RS03965	COG0163	prenyltransferase activity
GXP74_RS03970	COG1522	sequence-specific DNA binding
GXP74_RS03975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GXP74_RS03980	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GXP74_RS03995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GXP74_RS04005	COG0259	pyridoxamine-phosphate oxidase activity
GXP74_RS04015	COG4821	SIS domain
GXP74_RS04055	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GXP74_RS04065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GXP74_RS04075	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS04090	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS04095	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS04115	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS04125	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GXP74_RS04140	COG0640	Transcriptional regulator
GXP74_RS04160	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GXP74_RS04165	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GXP74_RS04175	COG2226	methyltransferase
GXP74_RS04200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXP74_RS04205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXP74_RS04210	COG0649	NAD binding
GXP74_RS04220	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GXP74_RS04225	COG1034	ATP synthesis coupled electron transport
GXP74_RS04230	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GXP74_RS04235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXP74_RS04245	COG0713	ATP synthesis coupled electron transport
GXP74_RS04250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GXP74_RS04260	COG1007	ATP synthesis coupled electron transport
GXP74_RS04275	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GXP74_RS04275	COG0674	pyruvate-flavodoxin oxidoreductase activity
GXP74_RS04280	COG1013	pyruvate-flavodoxin oxidoreductase activity
GXP74_RS04300	COG1349	DNA-binding transcription factor activity
GXP74_RS04315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GXP74_RS04320	COG2365	Tyrosine phosphatase family
GXP74_RS04325	COG2814	Major facilitator Superfamily
GXP74_RS04385	COG2197	response regulator
GXP74_RS04390	COG4585	Histidine kinase
GXP74_RS04420	COG0702	epimerase
GXP74_RS04430	COG0242	peptide deformylase activity
GXP74_RS04495	COG1595	DNA-templated transcription, initiation
GXP74_RS04510	COG0789	Transcriptional regulator
GXP74_RS04545	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS04555	COG2017	converts alpha-aldose to the beta-anomer
GXP74_RS04565	COG0745	RESPONSE REGULATOR receiver
GXP74_RS04570	COG2205	protein histidine kinase activity
GXP74_RS04575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GXP74_RS04590	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS04595	COG2124	cytochrome p450
GXP74_RS04605	COG0148	phosphopyruvate hydratase activity
GXP74_RS04625	COG1252	NADH dehydrogenase
GXP74_RS04630	COG2177	Part of the ABC transporter FtsEX involved in
GXP74_RS04635	COG1136	(ABC) transporter
GXP74_RS04635	COG0577	efflux transmembrane transporter activity
GXP74_RS04660	COG0183	Belongs to the thiolase family
GXP74_RS04700	COG0705	Rhomboid family
GXP74_RS04700	COG0457	Tetratricopeptide repeat
GXP74_RS04710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GXP74_RS04725	COG1846	Transcriptional regulator
GXP74_RS04730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GXP74_RS04765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GXP74_RS04775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXP74_RS04785	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GXP74_RS04795	COG3629	intracellular signal transduction
GXP74_RS04795	COG3903	Transcriptional regulator
GXP74_RS04800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GXP74_RS04825	COG1331	Highly conserved protein containing a thioredoxin domain
GXP74_RS04850	COG1331	Highly conserved protein containing a thioredoxin domain
GXP74_RS04855	COG1309	transcriptional regulator
GXP74_RS04860	COG0477	Major facilitator Superfamily
GXP74_RS04870	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GXP74_RS04880	COG0436	Aminotransferase
GXP74_RS04895	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GXP74_RS04905	COG0251	oxidation-reduction process
GXP74_RS04915	COG0667	Aldo Keto reductase
GXP74_RS04920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GXP74_RS04925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GXP74_RS04940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GXP74_RS04945	COG0450	alkyl hydroperoxide reductase
GXP74_RS04990	COG0114	fumarate hydratase activity
GXP74_RS05000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GXP74_RS05000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GXP74_RS05025	COG0778	Nitroreductase
GXP74_RS05030	COG1722	exodeoxyribonuclease VII activity
GXP74_RS05035	COG1570	exodeoxyribonuclease VII activity
GXP74_RS05040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GXP74_RS05055	COG0012	GTP binding
GXP74_RS05060	COG2161	toxin-antitoxin pair type II binding
GXP74_RS05065	COG4115	mRNA cleavage
GXP74_RS05080	COG0494	nUDIX hydrolase
GXP74_RS05100	COG1053	succinate dehydrogenase
GXP74_RS05130	COG0601	transmembrane transport
GXP74_RS05135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS05145	COG4608	Belongs to the ABC transporter superfamily
GXP74_RS05155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS05160	COG0601	transmembrane transport
GXP74_RS05180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXP74_RS05200	COG1131	(ABC) transporter
GXP74_RS05210	COG4585	Histidine kinase
GXP74_RS05215	COG2197	response regulator
GXP74_RS05225	COG2912	Transglutaminase-like superfamily
GXP74_RS05255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXP74_RS05260	COG1611	Belongs to the LOG family
GXP74_RS05265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GXP74_RS05275	COG0519	Catalyzes the synthesis of GMP from XMP
GXP74_RS05280	COG1024	Enoyl-CoA hydratase
GXP74_RS05305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXP74_RS05310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GXP74_RS05330	COG2239	Acts as a magnesium transporter
GXP74_RS05375	COG0513	Belongs to the DEAD box helicase family
GXP74_RS05415	COG0438	transferase activity, transferring glycosyl groups
GXP74_RS05480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXP74_RS05490	COG2188	Transcriptional regulator
GXP74_RS05560	COG3480	Lon protease (S16) C-terminal proteolytic domain
GXP74_RS05590	COG0586	Pfam SNARE associated Golgi protein
GXP74_RS05595	COG0483	inositol monophosphate 1-phosphatase activity
GXP74_RS05610	COG1162	GTPase activity
GXP74_RS05615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GXP74_RS05625	COG2135	peptidase activity
GXP74_RS05630	COG1595	DNA-templated transcription, initiation
GXP74_RS05635	COG5662	AntiSigma factor
GXP74_RS05645	COG0242	peptide deformylase activity
GXP74_RS05675	COG3751	2OG-Fe(II) oxygenase superfamily
GXP74_RS05705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GXP74_RS05730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GXP74_RS05760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GXP74_RS05775	COG1349	DNA-binding transcription factor activity
GXP74_RS05780	COG4770	biotin carboxylase activity
GXP74_RS05795	COG0424	maF-like protein
GXP74_RS05805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GXP74_RS05815	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GXP74_RS05825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GXP74_RS05830	COG2986	histidine ammonia-lyase
GXP74_RS05865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GXP74_RS05880	COG1228	amidohydrolase
GXP74_RS05885	COG0745	RESPONSE REGULATOR receiver
GXP74_RS05890	COG2205	protein histidine kinase activity
GXP74_RS05905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GXP74_RS05925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXP74_RS05930	COG1832	CoA-binding protein
GXP74_RS05935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GXP74_RS05940	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS05950	COG2076	Multidrug Resistance protein
GXP74_RS05955	COG0546	phosphoglycolate phosphatase activity
GXP74_RS05960	COG3842	ATPase activity
GXP74_RS05980	COG2188	Transcriptional regulator
GXP74_RS05990	COG1316	TRANSCRIPTIONal
GXP74_RS06010	COG0778	Nitroreductase
GXP74_RS06010	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GXP74_RS06015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GXP74_RS06020	COG2205	protein histidine kinase activity
GXP74_RS06025	COG0745	RESPONSE REGULATOR receiver
GXP74_RS06060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GXP74_RS06065	COG2835	tetraacyldisaccharide 4'-kinase activity
GXP74_RS06075	COG1482	cell wall glycoprotein biosynthetic process
GXP74_RS06085	COG0393	Putative heavy-metal-binding
GXP74_RS06095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GXP74_RS06125	COG0745	RESPONSE REGULATOR receiver
GXP74_RS06130	COG5002	protein histidine kinase activity
GXP74_RS06130	COG5000	phosphorelay sensor kinase activity
GXP74_RS06135	COG0823	Involved in the tonB-independent uptake of proteins
GXP74_RS06140	COG1040	competence protein
GXP74_RS06145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GXP74_RS06150	COG2197	response regulator
GXP74_RS06155	COG3214	Protein conserved in bacteria
GXP74_RS06160	COG0438	transferase activity, transferring glycosyl groups
GXP74_RS06180	COG0653	protein targeting
GXP74_RS06200	COG2902	Dehydrogenase
GXP74_RS06205	COG3842	ATPase activity
GXP74_RS06210	COG0395	ABC-type sugar transport system, permease component
GXP74_RS06210	COG0395	ABC-type sugar transport system, permease component
GXP74_RS06215	COG1175	transmembrane transport
GXP74_RS06220	COG1653	transport
GXP74_RS06230	COG1674	ftsk spoiiie
GXP74_RS06235	COG0515	serine threonine protein kinase
GXP74_RS06240	COG0515	serine threonine protein kinase
GXP74_RS06245	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GXP74_RS06260	COG2884	Cell division ATP-binding protein ftsE
GXP74_RS06270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GXP74_RS06280	COG3973	AAA domain
GXP74_RS06290	COG0776	regulation of translation
GXP74_RS06295	COG0728	peptidoglycan biosynthetic process
GXP74_RS06300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GXP74_RS06305	COG1678	Uncharacterized ACR, COG1678
GXP74_RS06315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXP74_RS06340	COG2814	Major facilitator Superfamily
GXP74_RS06355	COG3480	Lon protease (S16) C-terminal proteolytic domain
GXP74_RS06365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GXP74_RS06370	COG0277	FAD linked oxidase domain protein
GXP74_RS06380	COG0745	RESPONSE REGULATOR receiver
GXP74_RS06385	COG2205	protein histidine kinase activity
GXP74_RS06425	COG1335	isochorismatase
GXP74_RS06435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GXP74_RS06465	COG1234	tRNA 3'-trailer cleavage
GXP74_RS06470	COG1263	PTS System
GXP74_RS06475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GXP74_RS06480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GXP74_RS06485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GXP74_RS06520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GXP74_RS06530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXP74_RS06570	COG2733	membrane
GXP74_RS06575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GXP74_RS06580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXP74_RS06605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GXP74_RS06620	COG1175	transmembrane transport
GXP74_RS06630	COG0395	ABC-type sugar transport system, permease component
GXP74_RS06640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GXP74_RS06645	COG0531	amino acid
GXP74_RS06680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GXP74_RS06690	COG3469	chitinase activity
GXP74_RS06695	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GXP74_RS06700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS06735	COG3958	Transketolase
GXP74_RS06740	COG3959	Transketolase, thiamine diphosphate binding domain
GXP74_RS06745	COG0789	Transcriptional regulator
GXP74_RS06755	COG5001	Diguanylate cyclase
GXP74_RS06775	COG2315	Protein conserved in bacteria
GXP74_RS06800	COG1309	transcriptional regulator
GXP74_RS06840	COG0406	alpha-ribazole phosphatase activity
GXP74_RS06865	COG4608	Belongs to the ABC transporter superfamily
GXP74_RS06870	COG0444	Belongs to the ABC transporter superfamily
GXP74_RS06875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS06880	COG0601	transmembrane transport
GXP74_RS06885	COG1609	Transcriptional regulator
GXP74_RS06920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GXP74_RS06925	COG4977	sequence-specific DNA binding
GXP74_RS06930	COG1011	Hydrolase
GXP74_RS06935	COG0589	response to stress
GXP74_RS06940	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS06955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GXP74_RS06960	COG1309	transcriptional regulator
GXP74_RS06965	COG1733	regulation of RNA biosynthetic process
GXP74_RS06975	COG3467	pyridoxamine 5'-phosphate
GXP74_RS07050	COG1846	Transcriptional regulator
GXP74_RS07065	COG0386	Belongs to the glutathione peroxidase family
GXP74_RS07070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GXP74_RS07105	COG2261	transglycosylase associated protein
GXP74_RS07120	COG1846	Transcriptional regulator
GXP74_RS07125	COG1643	Atp-dependent helicase
GXP74_RS07135	COG0604	alcohol dehydrogenase
GXP74_RS07165	COG0629	single-stranded DNA binding
GXP74_RS07185	COG1376	ErfK ybiS ycfS ynhG family protein
GXP74_RS07195	COG2267	carboxylic ester hydrolase activity
GXP74_RS07205	COG2807	transmembrane transport
GXP74_RS07215	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS07230	COG0586	Pfam SNARE associated Golgi protein
GXP74_RS07255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS07260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS07265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS07270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS07300	COG1472	Belongs to the glycosyl hydrolase 3 family
GXP74_RS07330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXP74_RS07410	COG0519	Catalyzes the synthesis of GMP from XMP
GXP74_RS07420	COG1595	DNA-templated transcription, initiation
GXP74_RS07430	COG3012	SEC-C Motif Domain Protein
GXP74_RS07450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GXP74_RS07450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GXP74_RS07495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GXP74_RS07510	COG1486	melibiose metabolic process
GXP74_RS07525	COG0668	transmembrane transport
GXP74_RS07570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GXP74_RS07575	COG1268	BioY protein
GXP74_RS07580	COG0698	ribose 5-phosphate isomerase
GXP74_RS07635	COG1002	Type II restriction enzyme, methylase subunits
GXP74_RS07655	COG2188	Transcriptional regulator
GXP74_RS07715	COG2814	Major facilitator Superfamily
GXP74_RS07720	COG0544	peptidyl-prolyl cis-trans isomerase activity
GXP74_RS07725	COG0740	serine-type endopeptidase activity
GXP74_RS07730	COG0740	serine-type endopeptidase activity
GXP74_RS07735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GXP74_RS07750	COG0525	valine-tRNA ligase activity
GXP74_RS07760	COG0285	dihydrofolate synthase activity
GXP74_RS07770	COG0105	UTP biosynthetic process
GXP74_RS07775	COG1077	Cell shape determining protein MreB Mrl
GXP74_RS07790	COG0768	penicillin binding
GXP74_RS07795	COG0772	Belongs to the SEDS family
GXP74_RS07815	COG3511	phospholipase C
GXP74_RS07850	COG3655	Transcriptional regulator
GXP74_RS07860	COG3511	phospholipase C
GXP74_RS07875	COG1530	ribonuclease E activity
GXP74_RS07880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GXP74_RS07885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GXP74_RS07890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GXP74_RS07895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GXP74_RS07900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GXP74_RS07910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GXP74_RS07925	COG0501	Belongs to the peptidase M48B family
GXP74_RS07940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GXP74_RS07950	COG0799	negative regulation of ribosome biogenesis
GXP74_RS07955	COG0588	phosphoglycerate mutase activity
GXP74_RS07975	COG0477	Major facilitator Superfamily
GXP74_RS08010	COG0495	leucyl-tRNA aminoacylation
GXP74_RS08020	COG1307	EDD domain protein, DegV family
GXP74_RS08045	COG0268	Binds directly to 16S ribosomal RNA
GXP74_RS08050	COG2329	Antibiotic biosynthesis monooxygenase
GXP74_RS08060	COG0481	GTPase activity
GXP74_RS08105	COG0501	Belongs to the peptidase M48B family
GXP74_RS08110	COG1420	regulation of RNA biosynthetic process
GXP74_RS08115	COG0484	heat shock protein binding
GXP74_RS08125	COG0793	Belongs to the peptidase S41A family
GXP74_RS08125	COG4946	Tricorn protease homolog
GXP74_RS08130	COG0537	adenosine 5'-monophosphoramidase activity
GXP74_RS08135	COG1234	tRNA 3'-trailer cleavage
GXP74_RS08145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GXP74_RS08155	COG1473	amidohydrolase
GXP74_RS08170	COG1473	amidohydrolase
GXP74_RS08200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GXP74_RS08205	COG1609	Transcriptional regulator
GXP74_RS08210	COG0596	Alpha beta hydrolase
GXP74_RS08230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GXP74_RS08240	COG1381	Involved in DNA repair and RecF pathway recombination
GXP74_RS08245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GXP74_RS08255	COG0423	glycine-tRNA ligase activity
GXP74_RS08275	COG2197	response regulator
GXP74_RS08295	COG0477	Major facilitator Superfamily
GXP74_RS08300	COG0583	DNA-binding transcription factor activity
GXP74_RS08320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXP74_RS08345	COG0574	Belongs to the PEP-utilizing enzyme family
GXP74_RS08345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GXP74_RS08370	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GXP74_RS08380	COG0358	DNA primase activity
GXP74_RS08385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GXP74_RS08390	COG1070	Carbohydrate kinase
GXP74_RS08425	COG5650	phosphatidylinositol metabolic process
GXP74_RS08435	COG2130	NADP-dependent
GXP74_RS08450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXP74_RS08455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXP74_RS08460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXP74_RS08485	COG0789	Transcriptional regulator
GXP74_RS08490	COG0667	Aldo Keto reductase
GXP74_RS08510	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GXP74_RS08540	COG3654	unkown
GXP74_RS08555	COG1940	carbohydrate kinase activity
GXP74_RS08580	COG1358	cellular component organization or biogenesis
GXP74_RS08610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GXP74_RS08645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GXP74_RS08775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GXP74_RS08790	COG0667	Aldo Keto reductase
GXP74_RS08810	COG2124	cytochrome p450
GXP74_RS08815	COG0183	Belongs to the thiolase family
GXP74_RS08830	COG3845	ABC transporter
GXP74_RS08865	COG1309	transcriptional regulator
GXP74_RS08870	COG0438	transferase activity, transferring glycosyl groups
GXP74_RS08875	COG2226	methyltransferase
GXP74_RS08890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS08920	COG3511	phospholipase C
GXP74_RS08925	COG0183	Belongs to the thiolase family
GXP74_RS08930	COG2030	dehydratase
GXP74_RS08940	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS08960	COG0823	Involved in the tonB-independent uptake of proteins
GXP74_RS08960	COG4946	Tricorn protease homolog
GXP74_RS08960	COG1506	peptidase
GXP74_RS08965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GXP74_RS08980	COG3022	response to hydroperoxide
GXP74_RS09155	COG4941	Belongs to the sigma-70 factor family
GXP74_RS09180	COG2223	nitrite transmembrane transporter activity
GXP74_RS09225	COG1285	pathogenesis
GXP74_RS09230	COG0640	Transcriptional regulator
GXP74_RS09245	COG1397	ADP-ribosylglycohydrolase
GXP74_RS09270	COG3469	chitinase activity
GXP74_RS09285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GXP74_RS09345	COG0714	Associated with various cellular activities
GXP74_RS09380	COG1994	Peptidase M50
GXP74_RS09435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXP74_RS09440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GXP74_RS09445	COG0477	Major facilitator Superfamily
GXP74_RS09450	COG1309	transcriptional regulator
GXP74_RS09460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GXP74_RS09460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GXP74_RS09465	COG0174	glutamine synthetase
GXP74_RS09480	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GXP74_RS09500	COG1584	GPR1 FUN34 yaaH family protein
GXP74_RS09505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXP74_RS09530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GXP74_RS09540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GXP74_RS09545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GXP74_RS09545	COG2080	2 iron, 2 sulfur cluster binding
GXP74_RS09615	COG4941	Belongs to the sigma-70 factor family
GXP74_RS09620	COG3629	intracellular signal transduction
GXP74_RS09620	COG3903	Transcriptional regulator
GXP74_RS09630	COG4221	oxidoreductase activity
GXP74_RS09650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS09690	COG0515	serine threonine protein kinase
GXP74_RS09725	COG0789	Transcriptional regulator
GXP74_RS09740	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
GXP74_RS09770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GXP74_RS09775	COG0321	lipoyl(octanoyl) transferase activity
GXP74_RS09780	COG0667	Aldo Keto reductase
GXP74_RS09785	COG1309	transcriptional regulator
GXP74_RS09805	COG0456	acetyltransferase
GXP74_RS09815	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXP74_RS09820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GXP74_RS09825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GXP74_RS09830	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GXP74_RS09835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GXP74_RS09855	COG0667	Aldo Keto reductase
GXP74_RS09860	COG2226	methyltransferase
GXP74_RS09880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GXP74_RS09890	COG1522	sequence-specific DNA binding
GXP74_RS09895	COG0076	glutamate decarboxylase activity
GXP74_RS09920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GXP74_RS09925	COG1104	cysteine desulfurase activity
GXP74_RS09930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GXP74_RS09935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GXP74_RS09945	COG1376	ErfK ybiS ycfS ynhG family protein
GXP74_RS09955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GXP74_RS09960	COG0723	plastoquinol--plastocyanin reductase activity
GXP74_RS09970	COG1845	cytochrome c oxidase, subunit III
GXP74_RS09980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GXP74_RS09985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GXP74_RS10060	COG0003	Pfam Anion-transporting ATPase
GXP74_RS10070	COG1940	carbohydrate kinase activity
GXP74_RS10100	COG2197	response regulator
GXP74_RS10105	COG0205	6-phosphofructokinase activity
GXP74_RS10125	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GXP74_RS10130	COG0243	molybdopterin cofactor binding
GXP74_RS10145	COG2193	ferroxidase activity
GXP74_RS10150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GXP74_RS10160	COG0778	Nitroreductase
GXP74_RS10165	COG2815	serine threonine protein kinase
GXP74_RS10165	COG0515	serine threonine protein kinase
GXP74_RS10170	COG2022	thiamine diphosphate biosynthetic process
GXP74_RS10180	COG2022	thiamine diphosphate biosynthetic process
GXP74_RS10180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXP74_RS10195	COG0352	thiamine-phosphate diphosphorylase activity
GXP74_RS10215	COG1233	COG1233 Phytoene dehydrogenase and related
GXP74_RS10220	COG1309	transcriptional regulator
GXP74_RS10230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GXP74_RS10240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GXP74_RS10260	COG0714	Associated with various cellular activities
GXP74_RS10270	COG0275	rRNA processing
GXP74_RS10280	COG0768	penicillin binding
GXP74_RS10285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GXP74_RS10295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GXP74_RS10300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GXP74_RS10310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GXP74_RS10315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GXP74_RS10320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GXP74_RS10335	COG1799	cell septum assembly
GXP74_RS10350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GXP74_RS10360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GXP74_RS10400	COG0587	DNA-directed DNA polymerase activity
GXP74_RS10435	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GXP74_RS10440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GXP74_RS10445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GXP74_RS10450	COG0131	Imidazoleglycerol-phosphate dehydratase
GXP74_RS10460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GXP74_RS10465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GXP74_RS10470	COG0251	oxidation-reduction process
GXP74_RS10475	COG0107	imidazoleglycerol-phosphate synthase activity
GXP74_RS10485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GXP74_RS10490	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GXP74_RS10510	COG0134	indole-3-glycerol-phosphate synthase activity
GXP74_RS10515	COG0133	tryptophan synthase activity
GXP74_RS10520	COG0159	tryptophan synthase activity
GXP74_RS10540	COG2197	response regulator
GXP74_RS10555	COG4591	ABC-type transport system involved in lipoprotein release permease component
GXP74_RS10555	COG1136	(ABC) transporter
GXP74_RS10595	COG0531	amino acid
GXP74_RS10600	COG0531	amino acid
GXP74_RS10620	COG2050	protein possibly involved in aromatic compounds catabolism
GXP74_RS10630	COG2226	methyltransferase
GXP74_RS10640	COG2409	Drug exporters of the RND superfamily
GXP74_RS10645	COG0237	dephospho-CoA kinase activity
GXP74_RS10650	COG2233	PERMEase
GXP74_RS10680	COG2409	Drug exporters of the RND superfamily
GXP74_RS10695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GXP74_RS10700	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GXP74_RS10720	COG0529	Catalyzes the synthesis of activated sulfate
GXP74_RS10725	COG0175	sulfate reduction
GXP74_RS10735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GXP74_RS10740	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS10780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GXP74_RS10805	COG1309	transcriptional regulator
GXP74_RS10820	COG0110	maltose O-acetyltransferase activity
GXP74_RS10855	COG0494	nUDIX hydrolase
GXP74_RS10880	COG2957	Belongs to the agmatine deiminase family
GXP74_RS10885	COG0804	urea catabolic process
GXP74_RS10890	COG0831	urea catabolic process
GXP74_RS10890	COG0832	Belongs to the urease beta subunit family
GXP74_RS10895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GXP74_RS10915	COG1136	(ABC) transporter
GXP74_RS10940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GXP74_RS10950	COG1414	Transcriptional regulator
GXP74_RS11020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GXP74_RS11095	COG2351	hydroxyisourate hydrolase activity
GXP74_RS11115	COG3622	Belongs to the hyi family
GXP74_RS11120	COG2084	Dehydrogenase
GXP74_RS11125	COG3960	tartronate-semialdehyde synthase activity
GXP74_RS11130	COG1929	Belongs to the glycerate kinase type-1 family
GXP74_RS11135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GXP74_RS11140	COG4266	Belongs to the allantoicase family
GXP74_RS11145	COG0753	catalase activity
GXP74_RS11165	COG0346	lactoylglutathione lyase activity
GXP74_RS11175	COG2252	PERMEase
GXP74_RS11195	COG0339	signal peptide processing
GXP74_RS11200	COG3835	regulator
GXP74_RS11205	COG1940	carbohydrate kinase activity
GXP74_RS11210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GXP74_RS11215	COG0671	phosphoesterase, PA-phosphatase related
GXP74_RS11235	COG2755	lipolytic protein G-D-S-L family
GXP74_RS11285	COG2182	Extracellular solute-binding protein
GXP74_RS11295	COG3833	ABC-type maltose transport systems, permease component
GXP74_RS11300	COG0366	Alpha amylase catalytic
GXP74_RS11390	COG0726	polysaccharide deacetylase
GXP74_RS11435	COG1802	Transcriptional regulator
GXP74_RS11445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GXP74_RS11450	COG0540	Belongs to the ATCase OTCase family
GXP74_RS11455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GXP74_RS11465	COG0505	Belongs to the CarA family
GXP74_RS11470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GXP74_RS11475	COG0167	dihydroorotate dehydrogenase activity
GXP74_RS11480	COG0543	2 iron, 2 sulfur cluster binding
GXP74_RS11485	COG0167	dihydroorotate dehydrogenase activity
GXP74_RS11490	COG0284	orotidine-5'-phosphate decarboxylase activity
GXP74_RS11500	COG0194	GDP metabolic process
GXP74_RS11520	COG0393	Putative heavy-metal-binding
GXP74_RS11535	COG0242	peptide deformylase activity
GXP74_RS11540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GXP74_RS11550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GXP74_RS11635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GXP74_RS11640	COG4585	Histidine kinase
GXP74_RS11655	COG3201	nicotinamide mononucleotide transporter
GXP74_RS11660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GXP74_RS11660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GXP74_RS11665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GXP74_RS11670	COG0140	phosphoribosyl-ATP diphosphatase activity
GXP74_RS11675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GXP74_RS11685	COG3250	beta-galactosidase activity
GXP74_RS11695	COG1253	flavin adenine dinucleotide binding
GXP74_RS11700	COG4152	abc transporter atp-binding protein
GXP74_RS11710	COG0464	growth
GXP74_RS11720	COG1937	Protein conserved in bacteria
GXP74_RS11755	COG1216	Glycosyl transferase, family 2
GXP74_RS11770	COG0259	pyridoxamine-phosphate oxidase activity
GXP74_RS11815	COG0583	DNA-binding transcription factor activity
GXP74_RS11820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GXP74_RS11835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GXP74_RS11845	COG1309	transcriptional regulator
GXP74_RS11860	COG3345	alpha-galactosidase
GXP74_RS11895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GXP74_RS11900	COG0066	3-isopropylmalate dehydratase activity
GXP74_RS11905	COG4221	oxidoreductase activity
GXP74_RS11930	COG0829	nickel cation binding
GXP74_RS11935	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GXP74_RS11940	COG0830	nickel cation binding
GXP74_RS11945	COG0804	urea catabolic process
GXP74_RS11950	COG0832	Belongs to the urease beta subunit family
GXP74_RS11960	COG0831	urea catabolic process
GXP74_RS11990	COG0708	Exodeoxyribonuclease III
GXP74_RS12005	COG0745	RESPONSE REGULATOR receiver
GXP74_RS12010	COG0488	(ABC) transporter
GXP74_RS12015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXP74_RS12040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXP74_RS12065	COG0387	Pfam Sodium calcium exchanger
GXP74_RS12085	COG0431	NADPH-dependent FMN reductase
GXP74_RS12090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS12215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GXP74_RS12225	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS12255	COG0842	Transport permease protein
GXP74_RS12275	COG0254	rRNA binding
GXP74_RS12280	COG1846	Transcriptional regulator
GXP74_RS12285	COG2353	YceI-like domain
GXP74_RS12315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GXP74_RS12320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GXP74_RS12350	COG0477	Major facilitator Superfamily
GXP74_RS12355	COG1846	Transcriptional regulator
GXP74_RS12370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GXP74_RS12395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GXP74_RS12400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GXP74_RS12430	COG0708	Exodeoxyribonuclease III
GXP74_RS12440	COG0640	Transcriptional regulator
GXP74_RS12470	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS12495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GXP74_RS12515	COG2124	cytochrome p450
GXP74_RS12550	COG1309	transcriptional regulator
GXP74_RS12555	COG1946	Acyl-CoA thioesterase
GXP74_RS12565	COG1024	Enoyl-CoA hydratase
GXP74_RS12585	COG2132	Multicopper oxidase
GXP74_RS12590	COG0076	glutamate decarboxylase activity
GXP74_RS12595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GXP74_RS12605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GXP74_RS12640	COG2188	Transcriptional regulator
GXP74_RS12645	COG1940	carbohydrate kinase activity
GXP74_RS12660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GXP74_RS12665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GXP74_RS12670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GXP74_RS12685	COG0156	8-amino-7-oxononanoate synthase activity
GXP74_RS12710	COG0494	nUDIX hydrolase
GXP74_RS12715	COG0477	Major facilitator Superfamily
GXP74_RS12730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GXP74_RS12735	COG0205	6-phosphofructokinase activity
GXP74_RS12740	COG1492	cobalamin metabolic process
GXP74_RS12750	COG0242	peptide deformylase activity
GXP74_RS12760	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS12800	COG0183	Belongs to the thiolase family
GXP74_RS12805	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS12825	COG0395	ABC-type sugar transport system, permease component
GXP74_RS12860	COG1105	Belongs to the carbohydrate kinase PfkB family
GXP74_RS12865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GXP74_RS12875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GXP74_RS12880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GXP74_RS12885	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GXP74_RS12895	COG1132	(ABC) transporter
GXP74_RS12915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GXP74_RS12955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GXP74_RS12980	COG2949	membrane
GXP74_RS12985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GXP74_RS12995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GXP74_RS12995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GXP74_RS13020	COG1695	Transcriptional regulator
GXP74_RS13035	COG0110	maltose O-acetyltransferase activity
GXP74_RS13060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GXP74_RS13070	COG1349	DNA-binding transcription factor activity
GXP74_RS13100	COG0646	methionine synthase
GXP74_RS13100	COG1410	methionine synthase
GXP74_RS13110	COG0747	negative chemotaxis
GXP74_RS13115	COG2197	response regulator
GXP74_RS13125	COG1994	Peptidase M50
GXP74_RS13125	COG0517	IMP dehydrogenase activity
GXP74_RS13145	COG1222	aaa ATPase
GXP74_RS13150	COG4122	O-methyltransferase activity
GXP74_RS13165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GXP74_RS13170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GXP74_RS13175	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GXP74_RS13190	COG2378	regulation of single-species biofilm formation
GXP74_RS13210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GXP74_RS13215	COG0805	protein transport
GXP74_RS13270	COG2378	regulation of single-species biofilm formation
GXP74_RS13285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS13305	COG1116	anion transmembrane transporter activity
GXP74_RS13315	COG1276	copper resistance
GXP74_RS13315	COG2372	response to copper ion
GXP74_RS13335	COG3415	Transposase
GXP74_RS13335	COG2801	Transposase and inactivated derivatives
GXP74_RS13360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GXP74_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS13395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GXP74_RS13400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GXP74_RS13405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GXP74_RS13410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GXP74_RS13415	COG5002	protein histidine kinase activity
GXP74_RS13420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GXP74_RS13425	COG0072	phenylalanine-tRNA ligase activity
GXP74_RS13425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXP74_RS13430	COG0640	Transcriptional regulator
GXP74_RS13450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GXP74_RS13465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GXP74_RS13480	COG0587	DNA-directed DNA polymerase activity
GXP74_RS13490	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GXP74_RS13490	COG2066	Belongs to the glutaminase family
GXP74_RS13515	COG1024	Enoyl-CoA hydratase
GXP74_RS13520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GXP74_RS13540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GXP74_RS13545	COG2706	6-phosphogluconolactonase activity
GXP74_RS13585	COG3265	gluconokinase activity
GXP74_RS13590	COG3387	PFAM Glycoside hydrolase 15-related
GXP74_RS13600	COG1063	alcohol dehydrogenase
GXP74_RS13620	COG0477	Major facilitator Superfamily
GXP74_RS13655	COG0671	phosphoesterase, PA-phosphatase related
GXP74_RS13680	COG0587	DNA-directed DNA polymerase activity
GXP74_RS13705	COG0587	DNA-directed DNA polymerase activity
GXP74_RS13735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GXP74_RS13740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GXP74_RS13745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GXP74_RS13780	COG0494	nUDIX hydrolase
GXP74_RS13830	COG0300	oxidoreductase activity
GXP74_RS13835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GXP74_RS13840	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GXP74_RS13845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GXP74_RS13850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GXP74_RS13855	COG1438	arginine binding
GXP74_RS13860	COG0137	argininosuccinate synthase activity
GXP74_RS13865	COG0165	Argininosuccinate lyase
GXP74_RS13890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GXP74_RS13895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GXP74_RS13895	COG1648	precorrin-2 dehydrogenase activity
GXP74_RS13905	COG0515	serine threonine protein kinase
GXP74_RS13905	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GXP74_RS13985	COG5002	protein histidine kinase activity
GXP74_RS13985	COG2176	DNA-directed DNA polymerase activity
GXP74_RS14000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GXP74_RS14025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GXP74_RS14030	COG1560	Kdo2-lipid A biosynthetic process
GXP74_RS14035	COG0438	transferase activity, transferring glycosyl groups
GXP74_RS14045	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GXP74_RS14050	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GXP74_RS14055	COG0217	transcriptional regulatory protein
GXP74_RS14060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GXP74_RS14065	COG0632	four-way junction helicase activity
GXP74_RS14070	COG2255	four-way junction helicase activity
GXP74_RS14080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GXP74_RS14085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GXP74_RS14090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GXP74_RS14100	COG1196	nuclear chromosome segregation
GXP74_RS14105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GXP74_RS14115	COG0124	histidyl-tRNA synthetase
GXP74_RS14120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GXP74_RS14135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GXP74_RS14155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GXP74_RS14160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GXP74_RS14170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GXP74_RS14175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GXP74_RS14180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GXP74_RS14185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GXP74_RS14190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GXP74_RS14200	COG0006	proline dipeptidase activity
GXP74_RS14205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GXP74_RS14210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GXP74_RS14215	COG0477	Major facilitator Superfamily
GXP74_RS14225	COG2197	response regulator
GXP74_RS14235	COG0300	oxidoreductase activity
GXP74_RS14275	COG2197	response regulator
GXP74_RS14290	COG1725	Transcriptional regulator
GXP74_RS14295	COG3842	ATPase activity
GXP74_RS14335	COG0747	negative chemotaxis
GXP74_RS14340	COG0601	transmembrane transport
GXP74_RS14345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS14370	COG0076	glutamate decarboxylase activity
GXP74_RS14375	COG1309	transcriptional regulator
GXP74_RS14385	COG1134	teichoic acid transport
GXP74_RS14390	COG1562	ergosterol biosynthetic process
GXP74_RS14400	COG1233	COG1233 Phytoene dehydrogenase and related
GXP74_RS14410	COG1657	PFAM Prenyltransferase squalene oxidase
GXP74_RS14420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GXP74_RS14450	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS14455	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS14500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GXP74_RS14520	COG1309	transcriptional regulator
GXP74_RS14530	COG1940	carbohydrate kinase activity
GXP74_RS14535	COG0531	amino acid
GXP74_RS14550	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS14580	COG2072	flavoprotein involved in K transport
GXP74_RS14600	COG3104	oligopeptide transport
GXP74_RS14605	COG0588	phosphoglycerate mutase activity
GXP74_RS14610	COG3485	protocatechuate 3,4-dioxygenase
GXP74_RS14615	COG3485	protocatechuate 3,4-dioxygenase
GXP74_RS14635	COG1414	Transcriptional regulator
GXP74_RS14655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXP74_RS14685	COG0667	Aldo Keto reductase
GXP74_RS14690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS14695	COG2706	6-phosphogluconolactonase activity
GXP74_RS14700	COG3265	gluconokinase activity
GXP74_RS14725	COG1366	Belongs to the anti-sigma-factor antagonist family
GXP74_RS14730	COG2770	Histidine kinase
GXP74_RS14730	COG2208	phosphoserine phosphatase activity
GXP74_RS14735	COG0596	Alpha beta hydrolase
GXP74_RS14765	COG0028	Belongs to the TPP enzyme family
GXP74_RS14785	COG4948	Mandelate Racemase Muconate Lactonizing
GXP74_RS14790	COG3387	PFAM Glycoside hydrolase 15-related
GXP74_RS14795	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS14805	COG1834	amidinotransferase
GXP74_RS14820	COG2890	protein-(glutamine-N5) methyltransferase activity
GXP74_RS14825	COG1007	ATP synthesis coupled electron transport
GXP74_RS14835	COG2111	Na H antiporter
GXP74_RS14870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GXP74_RS14875	COG1024	Enoyl-CoA hydratase
GXP74_RS14885	COG4533	DNA binding
GXP74_RS14890	COG0601	transmembrane transport
GXP74_RS14900	COG4172	Belongs to the ABC transporter superfamily
GXP74_RS14910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS14915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS14920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS14945	COG1472	Belongs to the glycosyl hydrolase 3 family
GXP74_RS14990	COG0673	inositol 2-dehydrogenase activity
GXP74_RS15010	COG1846	Transcriptional regulator
GXP74_RS15010	COG1940	carbohydrate kinase activity
GXP74_RS15015	COG1940	carbohydrate kinase activity
GXP74_RS15035	COG0395	ABC-type sugar transport system, permease component
GXP74_RS15055	COG0395	ABC-type sugar transport system, permease component
GXP74_RS15060	COG1175	transmembrane transport
GXP74_RS15070	COG1609	Transcriptional regulator
GXP74_RS15100	COG2197	response regulator
GXP74_RS15110	COG1131	(ABC) transporter
GXP74_RS15120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GXP74_RS15135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GXP74_RS15160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GXP74_RS15180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GXP74_RS15190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXP74_RS15195	COG1595	DNA-templated transcription, initiation
GXP74_RS15240	COG0215	cysteine-tRNA ligase activity
GXP74_RS15245	COG0463	Glycosyl transferase, family 2
GXP74_RS15250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GXP74_RS15265	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GXP74_RS15270	COG4122	O-methyltransferase activity
GXP74_RS15275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GXP74_RS15295	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS15305	COG2814	Major facilitator Superfamily
GXP74_RS15310	COG1881	PFAM PEBP family protein
GXP74_RS15315	COG0515	serine threonine protein kinase
GXP74_RS15320	COG2070	2-Nitropropane dioxygenase
GXP74_RS15335	COG0693	protein deglycase activity
GXP74_RS15350	COG2197	response regulator
GXP74_RS15355	COG4585	Histidine kinase
GXP74_RS15390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GXP74_RS15400	COG2226	methyltransferase
GXP74_RS15420	COG3408	Glycogen debranching enzyme
GXP74_RS15420	COG3119	arylsulfatase activity
GXP74_RS15425	COG0542	response to heat
GXP74_RS15455	COG0586	Pfam SNARE associated Golgi protein
GXP74_RS15475	COG0022	dehydrogenase e1 component
GXP74_RS15480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GXP74_RS15495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXP74_RS15535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GXP74_RS15550	COG1819	glycosyl
GXP74_RS15565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXP74_RS15605	COG2814	Major facilitator Superfamily
GXP74_RS15630	COG0446	pyridine nucleotide-disulphide oxidoreductase
GXP74_RS15640	COG0656	L-ascorbic acid biosynthetic process
GXP74_RS15655	COG0367	asparagine synthase
GXP74_RS15660	COG0784	Response regulator, receiver
GXP74_RS15675	COG4251	negative regulation of phosphorylation
GXP74_RS15685	COG2837	iron assimilation
GXP74_RS15690	COG1077	Cell shape determining protein MreB Mrl
GXP74_RS15735	COG2208	phosphoserine phosphatase activity
GXP74_RS15740	COG0531	amino acid
GXP74_RS15765	COG0765	amino acid transport
GXP74_RS15785	COG0463	Glycosyl transferase, family 2
GXP74_RS15835	COG2814	Major facilitator Superfamily
GXP74_RS15840	COG1309	transcriptional regulator
GXP74_RS15845	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS15865	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GXP74_RS15885	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GXP74_RS15905	COG4948	Mandelate Racemase Muconate Lactonizing
GXP74_RS15910	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS15920	COG0247	lactate metabolic process
GXP74_RS15925	COG1139	Iron-sulfur cluster binding protein
GXP74_RS15930	COG1556	Lactate utilization protein
GXP74_RS15940	COG3618	amidohydrolase
GXP74_RS15955	COG3387	PFAM Glycoside hydrolase 15-related
GXP74_RS15980	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS16010	COG2027	D-alanyl-D-alanine carboxypeptidase
GXP74_RS16020	COG0492	ferredoxin-NADP+ reductase activity
GXP74_RS16025	COG0477	Major facilitator Superfamily
GXP74_RS16040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GXP74_RS16050	COG1799	cell septum assembly
GXP74_RS16055	COG2223	nitrite transmembrane transporter activity
GXP74_RS16095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXP74_RS16150	COG2813	Specifically methylates the guanine in position
GXP74_RS16160	COG1302	Protein conserved in bacteria
GXP74_RS16165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXP74_RS16210	COG1652	LysM domain
GXP74_RS16230	COG2050	protein possibly involved in aromatic compounds catabolism
GXP74_RS16255	COG0829	nickel cation binding
GXP74_RS16260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GXP74_RS16265	COG0830	nickel cation binding
GXP74_RS16270	COG0804	urea catabolic process
GXP74_RS16275	COG0832	Belongs to the urease beta subunit family
GXP74_RS16285	COG0831	urea catabolic process
GXP74_RS16290	COG4413	Urea transporter
GXP74_RS16295	COG1349	DNA-binding transcription factor activity
GXP74_RS16305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GXP74_RS16315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GXP74_RS16355	COG0504	CTP synthase activity
GXP74_RS16405	COG0667	Aldo Keto reductase
GXP74_RS16410	COG0028	Belongs to the TPP enzyme family
GXP74_RS16435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXP74_RS16440	COG3629	intracellular signal transduction
GXP74_RS16440	COG3903	Transcriptional regulator
GXP74_RS16465	COG4977	sequence-specific DNA binding
GXP74_RS16465	COG1917	Cupin 2, conserved barrel domain protein
GXP74_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS16525	COG2986	histidine ammonia-lyase
GXP74_RS16555	COG0596	Alpha beta hydrolase
GXP74_RS16585	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GXP74_RS16610	COG2376	Dihydroxyacetone kinase
GXP74_RS16615	COG2376	Dihydroxyacetone kinase
GXP74_RS16660	COG0375	protein maturation
GXP74_RS16665	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GXP74_RS16705	COG3237	CsbD-like
GXP74_RS16720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GXP74_RS16730	COG0745	RESPONSE REGULATOR receiver
GXP74_RS16755	COG0483	inositol monophosphate 1-phosphatase activity
GXP74_RS16800	COG0789	Transcriptional regulator
GXP74_RS16810	COG0542	response to heat
GXP74_RS16825	COG0667	Aldo Keto reductase
GXP74_RS16850	COG1473	amidohydrolase
GXP74_RS16855	COG3961	Belongs to the TPP enzyme family
GXP74_RS16895	COG1309	transcriptional regulator
GXP74_RS16900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXP74_RS16905	COG0531	amino acid
GXP74_RS16930	COG2318	DinB family
GXP74_RS16950	COG0583	DNA-binding transcription factor activity
GXP74_RS16960	COG2095	MarC family integral membrane protein
GXP74_RS16990	COG2080	2 iron, 2 sulfur cluster binding
GXP74_RS16990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GXP74_RS17000	COG3537	Alpha-1,2-mannosidase
GXP74_RS17085	COG2205	protein histidine kinase activity
GXP74_RS17085	COG0784	Response regulator, receiver
GXP74_RS17085	COG5002	protein histidine kinase activity
GXP74_RS17115	COG0243	molybdopterin cofactor binding
GXP74_RS17120	COG0745	RESPONSE REGULATOR receiver
GXP74_RS17125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GXP74_RS17125	COG2146	nitrite reductase [NAD(P)H] activity
GXP74_RS17135	COG2223	nitrite transmembrane transporter activity
GXP74_RS17170	COG2226	methyltransferase
GXP74_RS17190	COG2226	methyltransferase
GXP74_RS17195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXP74_RS17195	COG4499	WXG100 protein secretion system (Wss), protein YukC
GXP74_RS17205	COG0667	Aldo Keto reductase
GXP74_RS17210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GXP74_RS17255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GXP74_RS17305	COG0494	nUDIX hydrolase
GXP74_RS17330	COG1802	Transcriptional regulator
GXP74_RS17345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXP74_RS17350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXP74_RS17370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXP74_RS17380	COG3246	L-lysine catabolic process to acetate
GXP74_RS17385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GXP74_RS17425	COG2268	Band 7 protein
GXP74_RS17480	COG2124	cytochrome p450
GXP74_RS17500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXP74_RS17530	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GXP74_RS17540	COG0142	geranyltranstransferase activity
GXP74_RS17545	COG2124	cytochrome p450
GXP74_RS17570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXP74_RS17575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS17575	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GXP74_RS17580	COG0019	diaminopimelate decarboxylase activity
GXP74_RS17585	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS17680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXP74_RS17690	COG0596	Alpha beta hydrolase
GXP74_RS17695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GXP74_RS17700	COG4977	sequence-specific DNA binding
GXP74_RS17705	COG0783	Belongs to the Dps family
GXP74_RS17735	COG1472	Belongs to the glycosyl hydrolase 3 family
GXP74_RS17745	COG4209	transmembrane transport
GXP74_RS17750	COG0395	ABC-type sugar transport system, permease component
GXP74_RS17760	COG1609	Transcriptional regulator
GXP74_RS17900	COG1250	3-hydroxyacyl-CoA dehydrogenase
GXP74_RS18025	COG2197	response regulator
GXP74_RS18030	COG4585	Histidine kinase
GXP74_RS18040	COG1408	metallophosphoesterase
GXP74_RS18045	COG1506	peptidase
GXP74_RS18045	COG0823	Involved in the tonB-independent uptake of proteins
GXP74_RS18060	COG2318	DinB family
GXP74_RS18080	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS18090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GXP74_RS18100	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXP74_RS18125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GXP74_RS18200	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GXP74_RS18220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GXP74_RS18230	COG0583	DNA-binding transcription factor activity
GXP74_RS18235	COG0183	Belongs to the thiolase family
GXP74_RS18240	COG1024	Enoyl-CoA hydratase
GXP74_RS18255	COG4977	sequence-specific DNA binding
GXP74_RS18270	COG2070	2-Nitropropane dioxygenase
GXP74_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS18285	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS18290	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS18295	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS18330	COG0596	Alpha beta hydrolase
GXP74_RS18365	COG0601	transmembrane transport
GXP74_RS18370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS18375	COG0444	Belongs to the ABC transporter superfamily
GXP74_RS18380	COG4608	Belongs to the ABC transporter superfamily
GXP74_RS18395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS18405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS18415	COG2197	response regulator
GXP74_RS18420	COG0702	epimerase
GXP74_RS18430	COG3629	intracellular signal transduction
GXP74_RS18430	COG3903	Transcriptional regulator
GXP74_RS18500	COG2080	2 iron, 2 sulfur cluster binding
GXP74_RS18505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GXP74_RS18510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GXP74_RS18535	COG3629	intracellular signal transduction
GXP74_RS18535	COG3903	Transcriptional regulator
GXP74_RS18545	COG0667	Aldo Keto reductase
GXP74_RS18565	COG0477	Major facilitator Superfamily
GXP74_RS18570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXP74_RS18590	COG3938	Belongs to the proline racemase family
GXP74_RS18595	COG1802	Transcriptional regulator
GXP74_RS18600	COG0006	proline dipeptidase activity
GXP74_RS18605	COG3345	alpha-galactosidase
GXP74_RS18610	COG0583	DNA-binding transcription factor activity
GXP74_RS18615	COG4934	collagen metabolic process
GXP74_RS18635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GXP74_RS18645	COG0640	Transcriptional regulator
GXP74_RS18660	COG4221	oxidoreductase activity
GXP74_RS18670	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS18700	COG1733	regulation of RNA biosynthetic process
GXP74_RS18805	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS18820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXP74_RS18825	COG3345	alpha-galactosidase
GXP74_RS18830	COG3250	beta-galactosidase activity
GXP74_RS18835	COG3693	PFAM glycoside hydrolase, family 10
GXP74_RS18845	COG3345	alpha-galactosidase
GXP74_RS18875	COG1609	Transcriptional regulator
GXP74_RS18885	COG1879	ABC-type sugar transport system periplasmic component
GXP74_RS18890	COG1129	ABC transporter
GXP74_RS18895	COG1172	Belongs to the binding-protein-dependent transport system permease family
GXP74_RS18905	COG1609	Transcriptional regulator
GXP74_RS18920	COG0745	RESPONSE REGULATOR receiver
GXP74_RS18950	COG0501	Belongs to the peptidase M48B family
GXP74_RS18990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXP74_RS19010	COG0569	domain protein
GXP74_RS19010	COG0475	glutathione-regulated potassium exporter activity
GXP74_RS19025	COG3537	Alpha-1,2-mannosidase
GXP74_RS19040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GXP74_RS19060	COG0346	lactoylglutathione lyase activity
GXP74_RS19120	COG2234	aminopeptidase activity
GXP74_RS19160	COG1032	radical SAM domain protein
GXP74_RS19175	COG0328	RNA-DNA hybrid ribonuclease activity
GXP74_RS19235	COG0783	Belongs to the Dps family
GXP74_RS19245	COG2188	Transcriptional regulator
GXP74_RS19250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GXP74_RS19255	COG1053	succinate dehydrogenase
GXP74_RS19265	COG0583	DNA-binding transcription factor activity
GXP74_RS19270	COG2267	carboxylic ester hydrolase activity
GXP74_RS19275	COG2197	response regulator
GXP74_RS19285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXP74_RS19340	COG2814	Major facilitator Superfamily
GXP74_RS19355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXP74_RS19360	COG0395	ABC-type sugar transport system, permease component
GXP74_RS19365	COG1175	transmembrane transport
GXP74_RS19400	COG1733	regulation of RNA biosynthetic process
GXP74_RS19420	COG1733	regulation of RNA biosynthetic process
GXP74_RS19425	COG0702	epimerase
GXP74_RS19430	COG0640	Transcriptional regulator
GXP74_RS19450	COG4172	Belongs to the ABC transporter superfamily
GXP74_RS19460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS19530	COG4978	Transcriptional regulator
GXP74_RS19530	COG0789	Transcriptional regulator
GXP74_RS19535	COG0346	lactoylglutathione lyase activity
GXP74_RS19565	COG2249	NAD(P)H dehydrogenase (quinone) activity
GXP74_RS19570	COG0640	Transcriptional regulator
GXP74_RS19605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXP74_RS19720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GXP74_RS19745	COG4974	Belongs to the 'phage' integrase family
GXP74_RS19760	COG2188	Transcriptional regulator
GXP74_RS19785	COG0582	viral genome integration into host DNA
GXP74_RS19830	COG5297	Belongs to the glycosyl hydrolase family 6
GXP74_RS19830	COG4733	cellulase activity
GXP74_RS19835	COG1396	sequence-specific DNA binding
GXP74_RS19840	COG0740	serine-type endopeptidase activity
GXP74_RS19845	COG0740	serine-type endopeptidase activity
GXP74_RS19875	COG0800	Aldolase
GXP74_RS19880	COG4948	Mandelate Racemase Muconate Lactonizing
GXP74_RS19885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXP74_RS19890	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS19895	COG4974	Belongs to the 'phage' integrase family
GXP74_RS19935	COG1414	Transcriptional regulator
GXP74_RS19945	COG0395	ABC-type sugar transport system, permease component
GXP74_RS19950	COG1175	transmembrane transport
GXP74_RS20015	COG4585	Histidine kinase
GXP74_RS20055	COG1136	(ABC) transporter
GXP74_RS20080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS20100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS20120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS20125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS20135	COG0442	prolyl-tRNA aminoacylation
GXP74_RS20220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GXP74_RS20290	COG1309	transcriptional regulator
GXP74_RS20340	COG0281	malic enzyme
GXP74_RS20390	COG2267	carboxylic ester hydrolase activity
GXP74_RS20395	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS20400	COG1902	pentaerythritol trinitrate reductase activity
GXP74_RS20415	COG1940	carbohydrate kinase activity
GXP74_RS20440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GXP74_RS20480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GXP74_RS20520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXP74_RS20575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GXP74_RS20695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GXP74_RS20750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXP74_RS20765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GXP74_RS20795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GXP74_RS20835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GXP74_RS20860	COG1940	carbohydrate kinase activity
GXP74_RS20875	COG1902	pentaerythritol trinitrate reductase activity
GXP74_RS20880	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS20885	COG2267	carboxylic ester hydrolase activity
GXP74_RS20935	COG0281	malic enzyme
GXP74_RS20985	COG1309	transcriptional regulator
GXP74_RS21145	COG0442	prolyl-tRNA aminoacylation
GXP74_RS21195	COG1136	(ABC) transporter
GXP74_RS21230	COG2197	response regulator
GXP74_RS21235	COG4585	Histidine kinase
GXP74_RS21240	COG2175	clavaminate synthase activity
GXP74_RS21280	COG1175	transmembrane transport
GXP74_RS21285	COG0395	ABC-type sugar transport system, permease component
GXP74_RS21295	COG1414	Transcriptional regulator
GXP74_RS21335	COG4974	Belongs to the 'phage' integrase family
GXP74_RS21340	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS21345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXP74_RS21350	COG4948	Mandelate Racemase Muconate Lactonizing
GXP74_RS21355	COG0800	Aldolase
GXP74_RS21385	COG0740	serine-type endopeptidase activity
GXP74_RS21390	COG0740	serine-type endopeptidase activity
GXP74_RS21395	COG1396	sequence-specific DNA binding
GXP74_RS21400	COG4733	cellulase activity
GXP74_RS21400	COG5297	Belongs to the glycosyl hydrolase family 6
GXP74_RS21445	COG0582	viral genome integration into host DNA
GXP74_RS21470	COG2188	Transcriptional regulator
GXP74_RS21485	COG4974	Belongs to the 'phage' integrase family
GXP74_RS21510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GXP74_RS21625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXP74_RS21660	COG0640	Transcriptional regulator
GXP74_RS21665	COG2249	NAD(P)H dehydrogenase (quinone) activity
GXP74_RS21695	COG0346	lactoylglutathione lyase activity
GXP74_RS21700	COG4978	Transcriptional regulator
GXP74_RS21700	COG0789	Transcriptional regulator
GXP74_RS21770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS21780	COG4172	Belongs to the ABC transporter superfamily
GXP74_RS21800	COG0640	Transcriptional regulator
GXP74_RS21805	COG0702	epimerase
GXP74_RS21810	COG1733	regulation of RNA biosynthetic process
GXP74_RS21830	COG1733	regulation of RNA biosynthetic process
GXP74_RS21845	COG2182	Extracellular solute-binding protein
GXP74_RS21850	COG1175	transmembrane transport
GXP74_RS21915	COG0138	bifunctional purine biosynthesis protein purh
GXP74_RS21930	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS21960	COG1309	transcriptional regulator
GXP74_RS21985	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GXP74_RS21995	COG2135	peptidase activity
GXP74_RS22015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GXP74_RS22020	COG0509	glycine decarboxylation via glycine cleavage system
GXP74_RS22025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GXP74_RS22045	COG1733	regulation of RNA biosynthetic process
GXP74_RS22050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GXP74_RS22055	COG2267	carboxylic ester hydrolase activity
GXP74_RS22070	COG0456	acetyltransferase
GXP74_RS22070	COG0454	-acetyltransferase
GXP74_RS22080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GXP74_RS22085	COG0302	gtp cyclohydrolase
GXP74_RS22095	COG0720	synthase
GXP74_RS22100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GXP74_RS22105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GXP74_RS22125	COG2910	NAD(P)H-binding
GXP74_RS22155	COG4941	Belongs to the sigma-70 factor family
GXP74_RS22180	COG2318	DinB family
GXP74_RS22185	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS22215	COG1191	sigma factor activity
GXP74_RS22225	COG3237	CsbD-like
GXP74_RS22260	COG0784	Response regulator, receiver
GXP74_RS22275	COG0784	Response regulator, receiver
GXP74_RS22285	COG1366	Belongs to the anti-sigma-factor antagonist family
GXP74_RS22290	COG1366	Belongs to the anti-sigma-factor antagonist family
GXP74_RS22295	COG2172	sigma factor antagonist activity
GXP74_RS22305	COG5002	protein histidine kinase activity
GXP74_RS22305	COG2198	Histidine kinase
GXP74_RS22305	COG0784	Response regulator, receiver
GXP74_RS22335	COG2124	cytochrome p450
GXP74_RS22350	COG4638	Rieske (2fe-2S)
GXP74_RS22390	COG0702	epimerase
GXP74_RS22415	COG1191	sigma factor activity
GXP74_RS22440	COG0784	Response regulator, receiver
GXP74_RS22440	COG2205	protein histidine kinase activity
GXP74_RS22440	COG5002	protein histidine kinase activity
GXP74_RS22455	COG1191	sigma factor activity
GXP74_RS22460	COG2271	Major facilitator Superfamily
GXP74_RS22490	COG2318	DinB family
GXP74_RS22510	COG3973	AAA domain
GXP74_RS22520	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GXP74_RS22530	COG1902	pentaerythritol trinitrate reductase activity
GXP74_RS22550	COG3251	PFAM MbtH domain protein
GXP74_RS22565	COG3629	intracellular signal transduction
GXP74_RS22565	COG3903	Transcriptional regulator
GXP74_RS22575	COG0477	Major facilitator Superfamily
GXP74_RS22595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXP74_RS22600	COG3251	PFAM MbtH domain protein
GXP74_RS22625	COG3424	synthase
GXP74_RS22630	COG1024	Enoyl-CoA hydratase
GXP74_RS22635	COG1024	Enoyl-CoA hydratase
GXP74_RS22640	COG1024	Enoyl-CoA hydratase
GXP74_RS22715	COG0673	inositol 2-dehydrogenase activity
GXP74_RS22720	COG4702	Belongs to the UPF0303 family
GXP74_RS22790	COG2124	cytochrome p450
GXP74_RS22800	COG3903	Transcriptional regulator
GXP74_RS22800	COG3629	intracellular signal transduction
GXP74_RS22845	COG1695	Transcriptional regulator
GXP74_RS22890	COG0494	nUDIX hydrolase
GXP74_RS22905	COG0726	polysaccharide deacetylase
GXP74_RS22945	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GXP74_RS22950	COG0028	Belongs to the TPP enzyme family
GXP74_RS22960	COG0395	ABC-type sugar transport system, permease component
GXP74_RS22980	COG0542	response to heat
GXP74_RS22995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GXP74_RS23000	COG0443	Heat shock 70 kDa protein
GXP74_RS23005	COG3835	regulator
GXP74_RS23030	COG1335	isochorismatase
GXP74_RS23045	COG3209	COG3209 Rhs family protein
GXP74_RS23065	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GXP74_RS23070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GXP74_RS23160	COG3979	chitinase
GXP74_RS23165	COG1132	(ABC) transporter
GXP74_RS23175	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GXP74_RS23210	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS23230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXP74_RS23250	COG2197	response regulator
GXP74_RS23290	COG1309	transcriptional regulator
GXP74_RS23300	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GXP74_RS23330	COG1796	DNA polymerase
GXP74_RS23330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GXP74_RS23350	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GXP74_RS23355	COG1793	dna ligase
GXP74_RS23355	COG3285	dna ligase
GXP74_RS23360	COG1793	dna ligase
GXP74_RS23360	COG3285	dna ligase
GXP74_RS23405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GXP74_RS23410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GXP74_RS23430	COG1131	(ABC) transporter
GXP74_RS23445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GXP74_RS23450	COG0765	amino acid transport
GXP74_RS23490	COG3903	Transcriptional regulator
GXP74_RS23490	COG3629	intracellular signal transduction
GXP74_RS23515	COG1250	3-hydroxyacyl-CoA dehydrogenase
GXP74_RS23545	COG3572	ergothioneine biosynthetic process
GXP74_RS23555	COG0121	glutamine amidotransferase
GXP74_RS23570	COG1764	response to oxidative stress
GXP74_RS23590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GXP74_RS23690	COG5001	Diguanylate cyclase
GXP74_RS23740	COG4977	sequence-specific DNA binding
GXP74_RS23755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GXP74_RS23760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GXP74_RS23770	COG0180	Tryptophanyl-tRNA synthetase
GXP74_RS23775	COG1357	PFAM Pentapeptide repeats (8 copies)
GXP74_RS23780	COG1473	amidohydrolase
GXP74_RS23785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS23795	COG1116	anion transmembrane transporter activity
GXP74_RS23800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GXP74_RS23820	COG3619	membrane
GXP74_RS23835	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GXP74_RS23850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXP74_RS23855	COG1739	Uncharacterized protein family UPF0029
GXP74_RS23865	COG4221	oxidoreductase activity
GXP74_RS23885	COG4221	oxidoreductase activity
GXP74_RS23900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GXP74_RS23925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GXP74_RS23930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXP74_RS23945	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS23950	COG1414	Transcriptional regulator
GXP74_RS23955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GXP74_RS23960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GXP74_RS23965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GXP74_RS23975	COG2755	lipolytic protein G-D-S-L family
GXP74_RS24005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GXP74_RS24010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GXP74_RS24015	COG1984	allophanate hydrolase subunit 2
GXP74_RS24025	COG0438	transferase activity, transferring glycosyl groups
GXP74_RS24030	COG0438	transferase activity, transferring glycosyl groups
GXP74_RS24075	COG1024	Enoyl-CoA hydratase
GXP74_RS24120	COG0601	transmembrane transport
GXP74_RS24125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS24140	COG1764	response to oxidative stress
GXP74_RS24145	COG1846	Transcriptional regulator
GXP74_RS24155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GXP74_RS24160	COG2151	metal-sulfur cluster biosynthetic enzyme
GXP74_RS24165	COG3396	Phenylacetate-CoA oxygenase
GXP74_RS24170	COG3460	Phenylacetate-CoA oxygenase
GXP74_RS24175	COG3396	Phenylacetate-CoA oxygenase
GXP74_RS24190	COG0477	Major facilitator Superfamily
GXP74_RS24210	COG0529	Catalyzes the synthesis of activated sulfate
GXP74_RS24235	COG3321	synthase
GXP74_RS24235	COG4221	oxidoreductase activity
GXP74_RS24235	COG0604	alcohol dehydrogenase
GXP74_RS24235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS24240	COG1309	transcriptional regulator
GXP74_RS24265	COG2197	response regulator
GXP74_RS24270	COG4585	Histidine kinase
GXP74_RS24275	COG0644	oxidoreductase
GXP74_RS24300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GXP74_RS24340	COG0420	3'-5' exonuclease activity
GXP74_RS24345	COG0419	ATPase involved in DNA repair
GXP74_RS24350	COG0366	Alpha amylase catalytic
GXP74_RS24365	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS24370	COG0741	lytic transglycosylase activity
GXP74_RS24370	COG1196	nuclear chromosome segregation
GXP74_RS24370	COG0739	heme binding
GXP74_RS24375	COG0166	Belongs to the GPI family
GXP74_RS24380	COG4585	Histidine kinase
GXP74_RS24385	COG2197	response regulator
GXP74_RS24390	COG0513	Belongs to the DEAD box helicase family
GXP74_RS24405	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS24445	COG0531	amino acid
GXP74_RS24460	COG3511	phospholipase C
GXP74_RS24465	COG1119	ATPase activity
GXP74_RS24470	COG4733	cellulase activity
GXP74_RS24520	COG0495	leucyl-tRNA aminoacylation
GXP74_RS24525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GXP74_RS24540	COG2326	polyphosphate kinase activity
GXP74_RS24550	COG1486	melibiose metabolic process
GXP74_RS24555	COG4608	Belongs to the ABC transporter superfamily
GXP74_RS24560	COG0444	Belongs to the ABC transporter superfamily
GXP74_RS24590	COG0366	Alpha amylase catalytic
GXP74_RS24600	COG1175	transmembrane transport
GXP74_RS24605	COG1653	transport
GXP74_RS24620	COG0412	Dienelactone hydrolase
GXP74_RS24640	COG0589	response to stress
GXP74_RS24645	COG0363	glucosamine-6-phosphate deaminase activity
GXP74_RS24660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXP74_RS24705	COG1063	alcohol dehydrogenase
GXP74_RS24725	COG0477	Major facilitator Superfamily
GXP74_RS24740	COG0800	Aldolase
GXP74_RS24755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GXP74_RS24770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GXP74_RS24780	COG1063	alcohol dehydrogenase
GXP74_RS24785	COG0156	8-amino-7-oxononanoate synthase activity
GXP74_RS24790	COG0583	DNA-binding transcription factor activity
GXP74_RS24800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GXP74_RS24805	COG0640	Transcriptional regulator
GXP74_RS24810	COG2188	Transcriptional regulator
GXP74_RS24815	COG2175	clavaminate synthase activity
GXP74_RS24870	COG0640	Transcriptional regulator
GXP74_RS24875	COG1316	TRANSCRIPTIONal
GXP74_RS24900	COG1064	alcohol dehydrogenase
GXP74_RS24905	COG2197	response regulator
GXP74_RS24915	COG0464	growth
GXP74_RS24995	COG0697	spore germination
GXP74_RS25025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GXP74_RS25030	COG0640	Transcriptional regulator
GXP74_RS25035	COG0681	Belongs to the peptidase S26 family
GXP74_RS25045	COG2890	protein-(glutamine-N5) methyltransferase activity
GXP74_RS25050	COG0384	phenazine biosynthesis protein PhzF
GXP74_RS25060	COG3469	chitinase activity
GXP74_RS25090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GXP74_RS25100	COG0667	Aldo Keto reductase
GXP74_RS25105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GXP74_RS25115	COG0501	Belongs to the peptidase M48B family
GXP74_RS25205	COG5297	Belongs to the glycosyl hydrolase family 6
GXP74_RS25210	COG2770	Histidine kinase
GXP74_RS25210	COG2208	phosphoserine phosphatase activity
GXP74_RS25220	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS25250	COG1278	Cold shock
GXP74_RS25255	COG1652	LysM domain
GXP74_RS25270	COG1744	ABC transporter substrate-binding protein PnrA-like
GXP74_RS25305	COG1127	ABC transporter
GXP74_RS25315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GXP74_RS25370	COG1612	heme a metabolic process
GXP74_RS25405	COG3842	ATPase activity
GXP74_RS25425	COG2837	iron assimilation
GXP74_RS25465	COG3842	ATPase activity
GXP74_RS25485	COG1278	Cold shock
GXP74_RS25490	COG0514	ATP-dependent DNA helicase (RecQ)
GXP74_RS25505	COG0531	amino acid
GXP74_RS25510	COG0183	Belongs to the thiolase family
GXP74_RS25515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GXP74_RS25530	COG1285	pathogenesis
GXP74_RS25560	COG0477	Major facilitator Superfamily
GXP74_RS25565	COG1335	isochorismatase
GXP74_RS25580	COG1335	isochorismatase
GXP74_RS25605	COG0326	Molecular chaperone. Has ATPase activity
GXP74_RS25635	COG1515	deoxyribonuclease V activity
GXP74_RS25665	COG1215	transferase activity, transferring glycosyl groups
GXP74_RS25670	COG2755	lipolytic protein G-D-S-L family
GXP74_RS25670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GXP74_RS25680	COG0446	pyridine nucleotide-disulphide oxidoreductase
GXP74_RS25680	COG1902	pentaerythritol trinitrate reductase activity
GXP74_RS25715	COG4585	Histidine kinase
GXP74_RS25720	COG2197	response regulator
GXP74_RS25730	COG2409	Drug exporters of the RND superfamily
GXP74_RS25740	COG1940	carbohydrate kinase activity
GXP74_RS25745	COG2188	Transcriptional regulator
GXP74_RS25775	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS25820	COG1309	transcriptional regulator
GXP74_RS25855	COG3321	synthase
GXP74_RS25855	COG0604	alcohol dehydrogenase
GXP74_RS25860	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS25875	COG0747	negative chemotaxis
GXP74_RS25915	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS25925	COG1228	amidohydrolase
GXP74_RS25950	COG2409	Drug exporters of the RND superfamily
GXP74_RS25955	COG1309	transcriptional regulator
GXP74_RS25965	COG2267	carboxylic ester hydrolase activity
GXP74_RS25980	COG1309	transcriptional regulator
GXP74_RS25990	COG3537	Alpha-1,2-mannosidase
GXP74_RS26020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXP74_RS26030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXP74_RS26095	COG0736	holo-[acyl-carrier-protein] synthase activity
GXP74_RS26110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GXP74_RS26115	COG0501	Belongs to the peptidase M48B family
GXP74_RS26150	COG2814	Major facilitator Superfamily
GXP74_RS26160	COG0583	DNA-binding transcription factor activity
GXP74_RS26180	COG0395	ABC-type sugar transport system, permease component
GXP74_RS26205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GXP74_RS26240	COG2197	response regulator
GXP74_RS26245	COG4585	Histidine kinase
GXP74_RS26260	COG0726	polysaccharide deacetylase
GXP74_RS26270	COG2197	response regulator
GXP74_RS26290	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GXP74_RS26295	COG1609	Transcriptional regulator
GXP74_RS26310	COG0789	Transcriptional regulator
GXP74_RS26315	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GXP74_RS26320	COG1940	carbohydrate kinase activity
GXP74_RS26325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXP74_RS26330	COG4608	Belongs to the ABC transporter superfamily
GXP74_RS26335	COG0444	Belongs to the ABC transporter superfamily
GXP74_RS26355	COG3458	cephalosporin-C deacetylase activity
GXP74_RS26370	COG1609	Transcriptional regulator
GXP74_RS26385	COG0596	Alpha beta hydrolase
GXP74_RS26405	COG1309	transcriptional regulator
GXP74_RS26430	COG4865	methylaspartate mutase activity
GXP74_RS26435	COG0674	pyruvate-flavodoxin oxidoreductase activity
GXP74_RS26435	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GXP74_RS26440	COG1013	pyruvate-flavodoxin oxidoreductase activity
GXP74_RS26470	COG4989	oxidoreductase activity
GXP74_RS26480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GXP74_RS26490	COG0561	phosphatase activity
GXP74_RS26515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GXP74_RS26540	COG1131	(ABC) transporter
GXP74_RS26545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GXP74_RS26550	COG0662	Cupin 2, conserved barrel domain protein
GXP74_RS26555	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GXP74_RS26560	COG0366	Alpha amylase catalytic
GXP74_RS26575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS26575	COG0604	alcohol dehydrogenase
GXP74_RS26575	COG4221	oxidoreductase activity
GXP74_RS26575	COG3321	synthase
GXP74_RS26615	COG3629	intracellular signal transduction
GXP74_RS26615	COG3903	Transcriptional regulator
GXP74_RS26640	COG3458	cephalosporin-C deacetylase activity
GXP74_RS26650	COG1609	Transcriptional regulator
GXP74_RS26660	COG0601	transmembrane transport
GXP74_RS26665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS26670	COG0444	Belongs to the ABC transporter superfamily
GXP74_RS26675	COG4608	Belongs to the ABC transporter superfamily
GXP74_RS26680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXP74_RS26705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXP74_RS26715	COG2264	protein methyltransferase activity
GXP74_RS26765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GXP74_RS26770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GXP74_RS26775	COG2192	nodulation
GXP74_RS26785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS26785	COG2226	methyltransferase
GXP74_RS26785	COG3433	isochorismatase activity
GXP74_RS26790	COG0456	acetyltransferase
GXP74_RS26800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXP74_RS26800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXP74_RS26825	COG1846	Transcriptional regulator
GXP74_RS26840	COG3883	PFAM NLP P60 protein
GXP74_RS26840	COG0791	NLP P60 protein
GXP74_RS26855	COG4716	Myosin-crossreactive antigen
GXP74_RS26870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GXP74_RS26890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXP74_RS26920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GXP74_RS26930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXP74_RS26935	COG1233	COG1233 Phytoene dehydrogenase and related
GXP74_RS26940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXP74_RS26950	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GXP74_RS26960	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS26965	COG1891	lyase activity
GXP74_RS26970	COG0673	inositol 2-dehydrogenase activity
GXP74_RS26995	COG0833	amino acid
GXP74_RS27005	COG0395	ABC-type sugar transport system, permease component
GXP74_RS27015	COG1653	transport
GXP74_RS27025	COG1940	carbohydrate kinase activity
GXP74_RS27035	COG2188	Transcriptional regulator
GXP74_RS27040	COG1609	Transcriptional regulator
GXP74_RS27045	COG0673	inositol 2-dehydrogenase activity
GXP74_RS27060	COG1929	Belongs to the glycerate kinase type-1 family
GXP74_RS27080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXP74_RS27080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXP74_RS27090	COG1181	Belongs to the D-alanine--D-alanine ligase family
GXP74_RS27115	COG2197	response regulator
GXP74_RS27130	COG0277	FAD linked oxidase domain protein
GXP74_RS27135	COG1834	amidinotransferase
GXP74_RS27145	COG1335	isochorismatase
GXP74_RS27155	COG0475	glutathione-regulated potassium exporter activity
GXP74_RS27195	COG0151	Belongs to the GarS family
GXP74_RS27205	COG1940	carbohydrate kinase activity
GXP74_RS27205	COG1846	Transcriptional regulator
GXP74_RS27220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GXP74_RS27230	COG1175	transmembrane transport
GXP74_RS27235	COG0395	ABC-type sugar transport system, permease component
GXP74_RS27290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GXP74_RS27305	COG3511	phospholipase C
GXP74_RS27310	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GXP74_RS27330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GXP74_RS27355	COG2267	carboxylic ester hydrolase activity
GXP74_RS27370	COG2160	L-arabinose isomerase activity
GXP74_RS27375	COG1609	Transcriptional regulator
GXP74_RS27385	COG1129	ABC transporter
GXP74_RS27390	COG1172	Belongs to the binding-protein-dependent transport system permease family
GXP74_RS27425	COG0277	FAD linked oxidase domain protein
GXP74_RS27490	COG1609	Transcriptional regulator
GXP74_RS27500	COG2755	lipolytic protein G-D-S-L family
GXP74_RS27505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXP74_RS27515	COG1595	DNA-templated transcription, initiation
GXP74_RS27565	COG1136	(ABC) transporter
GXP74_RS27585	COG1181	Belongs to the D-alanine--D-alanine ligase family
GXP74_RS27590	COG1181	Belongs to the D-alanine--D-alanine ligase family
GXP74_RS27655	COG2124	cytochrome p450
GXP74_RS27665	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS27695	COG2197	response regulator
GXP74_RS27700	COG4585	Histidine kinase
GXP74_RS27740	COG1472	Belongs to the glycosyl hydrolase 3 family
GXP74_RS27750	COG0583	DNA-binding transcription factor activity
GXP74_RS27755	COG0367	asparagine synthase
GXP74_RS27765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GXP74_RS27770	COG2814	Major facilitator Superfamily
GXP74_RS27785	COG4585	Histidine kinase
GXP74_RS27790	COG2197	response regulator
GXP74_RS27850	COG3851	Histidine kinase
GXP74_RS27860	COG0477	Major facilitator Superfamily
GXP74_RS27870	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS27875	COG2211	Major facilitator Superfamily
GXP74_RS27885	COG0235	Class ii aldolase
GXP74_RS27900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS27955	COG0463	Glycosyl transferase, family 2
GXP74_RS28005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GXP74_RS28010	COG0673	inositol 2-dehydrogenase activity
GXP74_RS28035	COG0584	glycerophosphoryl diester phosphodiesterase
GXP74_RS28040	COG2072	flavoprotein involved in K transport
GXP74_RS28045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GXP74_RS28050	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS28070	COG0251	oxidation-reduction process
GXP74_RS28080	COG0069	glutamate synthase activity
GXP74_RS28090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GXP74_RS28105	COG0581	inorganic phosphate transmembrane transporter activity
GXP74_RS28165	COG0477	Major facilitator Superfamily
GXP74_RS28175	COG0179	Fumarylacetoacetate (FAA) hydrolase
GXP74_RS28210	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS28235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GXP74_RS28240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GXP74_RS28290	COG0395	ABC-type sugar transport system, permease component
GXP74_RS28295	COG1175	transmembrane transport
GXP74_RS28305	COG1940	carbohydrate kinase activity
GXP74_RS28345	COG3321	synthase
GXP74_RS28345	COG0604	alcohol dehydrogenase
GXP74_RS28380	COG0477	Major facilitator Superfamily
GXP74_RS28385	COG0477	Major facilitator Superfamily
GXP74_RS28435	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXP74_RS28450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXP74_RS28455	COG3903	Transcriptional regulator
GXP74_RS28455	COG3629	intracellular signal transduction
GXP74_RS28475	COG1509	lysine 2,3-aminomutase activity
GXP74_RS28520	COG0445	tRNA wobble uridine modification
GXP74_RS28525	COG1595	DNA-templated transcription, initiation
GXP74_RS28540	COG2226	methyltransferase
GXP74_RS28580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GXP74_RS28585	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GXP74_RS28590	COG1120	ATPase activity
GXP74_RS28610	COG0702	epimerase
GXP74_RS28635	COG1278	Cold shock
GXP74_RS28640	COG0513	Belongs to the DEAD box helicase family
GXP74_RS28645	COG1819	glycosyl
GXP74_RS28655	COG1834	amidinotransferase
GXP74_RS28660	COG3903	Transcriptional regulator
GXP74_RS28660	COG3629	intracellular signal transduction
GXP74_RS28675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS28690	COG2124	cytochrome p450
GXP74_RS28745	COG0477	Major facilitator Superfamily
GXP74_RS28755	COG1191	sigma factor activity
GXP74_RS28775	COG2770	Histidine kinase
GXP74_RS28775	COG2208	phosphoserine phosphatase activity
GXP74_RS28805	COG3469	chitinase activity
GXP74_RS28825	COG1082	Xylose isomerase domain protein TIM barrel
GXP74_RS28840	COG1940	carbohydrate kinase activity
GXP74_RS28845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GXP74_RS28855	COG2814	Major facilitator Superfamily
GXP74_RS28890	COG0601	transmembrane transport
GXP74_RS28905	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GXP74_RS28910	COG2259	Doxx family
GXP74_RS28915	COG1511	domain protein
GXP74_RS28965	COG0395	ABC-type sugar transport system, permease component
GXP74_RS28970	COG1175	transmembrane transport
GXP74_RS28980	COG1609	Transcriptional regulator
GXP74_RS28990	COG3511	phospholipase C
GXP74_RS29010	COG0151	Belongs to the GarS family
GXP74_RS29015	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GXP74_RS29020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GXP74_RS29025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS29030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS29035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GXP74_RS29040	COG2423	ornithine cyclodeaminase activity
GXP74_RS29045	COG2197	response regulator
GXP74_RS29065	COG1940	carbohydrate kinase activity
GXP74_RS29085	COG1595	DNA-templated transcription, initiation
GXP74_RS29090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GXP74_RS29120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GXP74_RS29130	COG0492	ferredoxin-NADP+ reductase activity
GXP74_RS29140	COG2124	cytochrome p450
GXP74_RS29145	COG0475	glutathione-regulated potassium exporter activity
GXP74_RS29150	COG0745	RESPONSE REGULATOR receiver
GXP74_RS29155	COG2205	protein histidine kinase activity
GXP74_RS29185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXP74_RS29215	COG3469	chitinase activity
GXP74_RS29250	COG1846	Transcriptional regulator
GXP74_RS29320	COG1309	transcriptional regulator
GXP74_RS29415	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GXP74_RS29425	COG2197	response regulator
GXP74_RS29455	COG2801	Transposase and inactivated derivatives
GXP74_RS29485	COG3293	Transposase
GXP74_RS29495	COG0667	Aldo Keto reductase
GXP74_RS29500	COG0583	DNA-binding transcription factor activity
GXP74_RS29510	COG0667	Aldo Keto reductase
GXP74_RS29515	COG1309	transcriptional regulator
GXP74_RS29520	COG0596	Alpha beta hydrolase
GXP74_RS29550	COG2255	four-way junction helicase activity
GXP74_RS29565	COG2197	response regulator
GXP74_RS29570	COG2197	response regulator
GXP74_RS29575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GXP74_RS29580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GXP74_RS29590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS29595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS29605	COG2175	clavaminate synthase activity
GXP74_RS29630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GXP74_RS29690	COG1366	Belongs to the anti-sigma-factor antagonist family
GXP74_RS29695	COG1366	Belongs to the anti-sigma-factor antagonist family
GXP74_RS29700	COG2172	sigma factor antagonist activity
GXP74_RS29740	COG3251	PFAM MbtH domain protein
GXP74_RS29755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GXP74_RS29775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS29805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GXP74_RS29815	COG0148	phosphopyruvate hydratase activity
GXP74_RS29840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GXP74_RS29860	COG0154	amidase activity
GXP74_RS29990	COG1946	Acyl-CoA thioesterase
GXP74_RS30005	COG1652	LysM domain
GXP74_RS30030	COG1160	GTP binding
GXP74_RS30035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GXP74_RS30045	COG0697	spore germination
GXP74_RS30050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GXP74_RS30075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GXP74_RS30110	COG1187	pseudouridine synthase activity
GXP74_RS30115	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GXP74_RS30120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GXP74_RS30135	COG0686	Belongs to the AlaDH PNT family
GXP74_RS30145	COG0494	nUDIX hydrolase
GXP74_RS30150	COG0504	CTP synthase activity
GXP74_RS30155	COG3387	PFAM Glycoside hydrolase 15-related
GXP74_RS30160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXP74_RS30165	COG0297	glycogen (starch) synthase activity
GXP74_RS30170	COG0497	DNA recombination
GXP74_RS30175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GXP74_RS30200	COG0647	UMP catabolic process
GXP74_RS30240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GXP74_RS30250	COG2094	Belongs to the DNA glycosylase MPG family
GXP74_RS30255	COG1881	PFAM PEBP family protein
GXP74_RS30270	COG2154	pterin-4-alpha-carbinolamine dehydratase
GXP74_RS30290	COG1119	ATPase activity
GXP74_RS30300	COG2197	response regulator
GXP74_RS30305	COG4585	Histidine kinase
GXP74_RS30315	COG1131	(ABC) transporter
GXP74_RS30315	COG0842	Transport permease protein
GXP74_RS30315	COG1716	ATPase activity
GXP74_RS30320	COG3830	Belongs to the UPF0237 family
GXP74_RS30320	COG0560	Phosphoserine phosphatase
GXP74_RS30335	COG2186	Transcriptional regulator
GXP74_RS30355	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS30385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GXP74_RS30395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GXP74_RS30400	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS30410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GXP74_RS30420	COG3387	PFAM Glycoside hydrolase 15-related
GXP74_RS30445	COG1302	Protein conserved in bacteria
GXP74_RS30455	COG1024	Enoyl-CoA hydratase
GXP74_RS30465	COG0488	(ABC) transporter
GXP74_RS30500	COG0728	peptidoglycan biosynthetic process
GXP74_RS30515	COG0438	transferase activity, transferring glycosyl groups
GXP74_RS30530	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GXP74_RS30550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXP74_RS30550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXP74_RS30565	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS30570	COG0688	phosphatidylethanolamine metabolic process
GXP74_RS30580	COG0477	Major facilitator Superfamily
GXP74_RS30605	COG0174	glutamine synthetase
GXP74_RS30620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXP74_RS30635	COG1492	cobalamin metabolic process
GXP74_RS30655	COG1797	cobyrinic acid a,c-diamide synthase activity
GXP74_RS30670	COG0726	polysaccharide deacetylase
GXP74_RS30670	COG1649	PFAM Uncharacterised BCR, COG1649
GXP74_RS30675	COG1216	Glycosyl transferase, family 2
GXP74_RS30715	COG0463	Glycosyl transferase, family 2
GXP74_RS30750	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GXP74_RS30785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GXP74_RS30820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXP74_RS30825	COG2310	stress, protein
GXP74_RS30870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS30875	COG0601	transmembrane transport
GXP74_RS30900	COG0506	proline dehydrogenase activity
GXP74_RS30905	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS30945	COG2151	metal-sulfur cluster biosynthetic enzyme
GXP74_RS30950	COG0822	iron-sulfur transferase activity
GXP74_RS30955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GXP74_RS30960	COG0396	ATPase activity
GXP74_RS30970	COG0719	Fe-S assembly protein
GXP74_RS31025	COG0109	protoheme IX farnesyltransferase activity
GXP74_RS31030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GXP74_RS31035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GXP74_RS31050	COG0363	glucosamine-6-phosphate deaminase activity
GXP74_RS31075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXP74_RS31090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GXP74_RS31095	COG0149	triose-phosphate isomerase activity
GXP74_RS31100	COG0126	phosphoglycerate kinase activity
GXP74_RS31105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GXP74_RS31110	COG1481	regulation of sporulation
GXP74_RS31120	COG1660	Displays ATPase and GTPase activities
GXP74_RS31125	COG0322	excinuclease ABC activity
GXP74_RS31150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GXP74_RS31160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXP74_RS31185	COG1278	Cold shock
GXP74_RS31200	COG1278	Cold shock
GXP74_RS31205	COG1278	Cold shock
GXP74_RS31215	COG0583	DNA-binding transcription factor activity
GXP74_RS31255	COG0556	nucleotide-excision repair
GXP74_RS31275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GXP74_RS31280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GXP74_RS31295	COG0515	serine threonine protein kinase
GXP74_RS31295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GXP74_RS31320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GXP74_RS31340	COG0183	Belongs to the thiolase family
GXP74_RS31345	COG1250	3-hydroxyacyl-CoA dehydrogenase
GXP74_RS31345	COG1024	Enoyl-CoA hydratase
GXP74_RS31350	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GXP74_RS31370	COG4214	carbohydrate transport
GXP74_RS31380	COG4213	ABC transporter substrate-binding protein
GXP74_RS31385	COG1940	carbohydrate kinase activity
GXP74_RS31400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GXP74_RS31410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GXP74_RS31430	COG2171	N-acyltransferase activity
GXP74_RS31470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GXP74_RS31475	COG0531	amino acid
GXP74_RS31480	COG0569	domain protein
GXP74_RS31580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GXP74_RS31580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GXP74_RS31645	COG4195	phage-related replication protein
GXP74_RS31760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXP74_RS31765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GXP74_RS31770	COG2175	clavaminate synthase activity
GXP74_RS31775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GXP74_RS31780	COG1116	anion transmembrane transporter activity
GXP74_RS31790	COG0756	dUTP diphosphatase activity
GXP74_RS31820	COG2205	protein histidine kinase activity
GXP74_RS31825	COG0745	RESPONSE REGULATOR receiver
GXP74_RS31890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GXP74_RS31895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXP74_RS31925	COG2072	flavoprotein involved in K transport
GXP74_RS31960	COG1690	Belongs to the RtcB family
GXP74_RS31990	COG0612	Peptidase, M16
GXP74_RS31995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GXP74_RS32005	COG4264	IucA IucC family
GXP74_RS32015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GXP74_RS32025	COG2197	response regulator
GXP74_RS32030	COG4585	Histidine kinase
GXP74_RS32040	COG0187	DNA topoisomerase II activity
GXP74_RS32055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GXP74_RS32070	COG3842	ATPase activity
GXP74_RS32075	COG1051	belongs to the nudix hydrolase family
GXP74_RS32075	COG1056	cytidyltransferase-related domain
GXP74_RS32100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GXP74_RS32115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXP74_RS32125	COG1733	regulation of RNA biosynthetic process
GXP74_RS32140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GXP74_RS32145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GXP74_RS32155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GXP74_RS32180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GXP74_RS32185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GXP74_RS32190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GXP74_RS32200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GXP74_RS32215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GXP74_RS32240	COG2205	protein histidine kinase activity
GXP74_RS32245	COG0745	RESPONSE REGULATOR receiver
GXP74_RS32250	COG1126	abc transporter atp-binding protein
GXP74_RS32255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXP74_RS32270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GXP74_RS32275	COG1418	mRNA catabolic process
GXP74_RS32280	COG2137	regulation of response to DNA damage stimulus
GXP74_RS32285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GXP74_RS32305	COG2207	Transcriptional regulator
GXP74_RS32305	COG1917	Cupin 2, conserved barrel domain protein
GXP74_RS32325	COG1201	RNA secondary structure unwinding
GXP74_RS32335	COG1396	sequence-specific DNA binding
GXP74_RS32340	COG1546	Belongs to the CinA family
GXP74_RS32340	COG1058	Belongs to the CinA family
GXP74_RS32350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GXP74_RS32360	COG1674	ftsk spoiiie
GXP74_RS32370	COG0784	Response regulator, receiver
GXP74_RS32370	COG2205	protein histidine kinase activity
GXP74_RS32375	COG2770	Histidine kinase
GXP74_RS32375	COG2208	phosphoserine phosphatase activity
GXP74_RS32390	COG3135	benzoate transporter
GXP74_RS32410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GXP74_RS32415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXP74_RS32420	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GXP74_RS32435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GXP74_RS32440	COG0612	Peptidase, M16
GXP74_RS32445	COG1185	polyribonucleotide nucleotidyltransferase activity
GXP74_RS32450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GXP74_RS32460	COG1674	ftsk spoiiie
GXP74_RS32485	COG1404	Belongs to the peptidase S8 family
GXP74_RS32515	COG0455	bacterial-type flagellum organization
GXP74_RS32530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GXP74_RS32535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GXP74_RS32540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GXP74_RS32550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GXP74_RS32565	COG0779	Required for maturation of 30S ribosomal subunits
GXP74_RS32575	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GXP74_RS32580	COG4585	Histidine kinase
GXP74_RS32595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GXP74_RS32605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GXP74_RS32615	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS32630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GXP74_RS32660	COG1309	transcriptional regulator
GXP74_RS32675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXP74_RS32700	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS32710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GXP74_RS32725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GXP74_RS32730	COG0575	Belongs to the CDS family
GXP74_RS32735	COG0233	cytoplasmic translational termination
GXP74_RS32740	COG0528	UMP kinase activity
GXP74_RS32745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GXP74_RS32750	COG0052	Belongs to the universal ribosomal protein uS2 family
GXP74_RS32765	COG1191	sigma factor activity
GXP74_RS32780	COG0792	nuclease activity
GXP74_RS32790	COG1051	belongs to the nudix hydrolase family
GXP74_RS32805	COG0681	Belongs to the peptidase S26 family
GXP74_RS32815	COG0335	large ribosomal subunit rRNA binding
GXP74_RS32820	COG0336	Belongs to the RNA methyltransferase TrmD family
GXP74_RS32825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GXP74_RS32830	COG1837	Belongs to the UPF0109 family
GXP74_RS32835	COG0228	four-way junction DNA binding
GXP74_RS32845	COG0442	prolyl-tRNA aminoacylation
GXP74_RS32855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GXP74_RS32870	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GXP74_RS32900	COG1196	nuclear chromosome segregation
GXP74_RS32910	COG1254	Belongs to the acylphosphatase family
GXP74_RS32920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GXP74_RS32925	COG0571	ribonuclease III activity
GXP74_RS32930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GXP74_RS32945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GXP74_RS32950	COG0742	ribosomal rna small subunit methyltransferase
GXP74_RS32965	COG1461	Dihydroxyacetone kinase
GXP74_RS32970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GXP74_RS32975	COG0351	phosphomethylpyrimidine kinase
GXP74_RS32980	COG0205	6-phosphofructokinase activity
GXP74_RS33005	COG1181	Belongs to the D-alanine--D-alanine ligase family
GXP74_RS33010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GXP74_RS33020	COG1920	GTP binding
GXP74_RS33030	COG0776	regulation of translation
GXP74_RS33040	COG0066	3-isopropylmalate dehydratase activity
GXP74_RS33045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GXP74_RS33050	COG1414	Transcriptional regulator
GXP74_RS33100	COG0179	Fumarylacetoacetate (FAA) hydrolase
GXP74_RS33115	COG2018	Roadblock/LC7 domain
GXP74_RS33135	COG2018	Roadblock/LC7 domain
GXP74_RS33150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GXP74_RS33160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GXP74_RS33165	COG0473	3-isopropylmalate dehydrogenase activity
GXP74_RS33175	COG0287	Prephenate dehydrogenase
GXP74_RS33175	COG1605	Chorismate mutase
GXP74_RS33185	COG1404	Belongs to the peptidase S8 family
GXP74_RS33200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GXP74_RS33205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GXP74_RS33210	COG0440	acetolactate synthase activity
GXP74_RS33220	COG5001	Diguanylate cyclase
GXP74_RS33230	COG1672	PFAM Archaeal ATPase
GXP74_RS33230	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GXP74_RS33245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GXP74_RS33255	COG1106	Psort location Cytoplasmic, score
GXP74_RS33265	COG0154	amidase activity
GXP74_RS33270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GXP74_RS33280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GXP74_RS33305	COG0482	sulfurtransferase activity
GXP74_RS33315	COG1414	Transcriptional regulator
GXP74_RS33320	COG2860	membrane
GXP74_RS33330	COG4166	transmembrane transport
GXP74_RS33345	COG4608	Belongs to the ABC transporter superfamily
GXP74_RS33360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GXP74_RS33365	COG0509	glycine decarboxylation via glycine cleavage system
GXP74_RS33370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GXP74_RS33375	COG1760	l-serine dehydratase
GXP74_RS33400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GXP74_RS33410	COG0477	Major facilitator Superfamily
GXP74_RS33435	COG0791	NLP P60 protein
GXP74_RS33435	COG3883	PFAM NLP P60 protein
GXP74_RS33445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXP74_RS33460	COG1917	Cupin 2, conserved barrel domain protein
GXP74_RS33460	COG4977	sequence-specific DNA binding
GXP74_RS33490	COG1881	PFAM PEBP family protein
GXP74_RS33520	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GXP74_RS33535	COG3394	polysaccharide catabolic process
GXP74_RS33540	COG1316	TRANSCRIPTIONal
GXP74_RS33585	COG0326	Molecular chaperone. Has ATPase activity
GXP74_RS33625	COG1376	ErfK ybiS ycfS ynhG family protein
GXP74_RS33650	COG1132	(ABC) transporter
GXP74_RS33655	COG1132	(ABC) transporter
GXP74_RS33700	COG1316	TRANSCRIPTIONal
GXP74_RS33705	COG0058	SHG alpha-glucan phosphorylase activity
GXP74_RS33710	COG0366	Alpha amylase catalytic
GXP74_RS33720	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GXP74_RS33725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GXP74_RS33745	COG0857	belongs to the CobB CobQ family
GXP74_RS33745	COG0280	phosphate acetyltransferase
GXP74_RS33750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GXP74_RS33790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXP74_RS33790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXP74_RS33825	COG0183	Belongs to the thiolase family
GXP74_RS33845	COG2267	carboxylic ester hydrolase activity
GXP74_RS33850	COG1131	(ABC) transporter
GXP74_RS33860	COG1131	(ABC) transporter
GXP74_RS33885	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GXP74_RS33905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GXP74_RS33920	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GXP74_RS33925	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GXP74_RS33930	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GXP74_RS33935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GXP74_RS33940	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GXP74_RS33945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GXP74_RS33950	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GXP74_RS33965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GXP74_RS33970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GXP74_RS33975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GXP74_RS33985	COG2890	protein-(glutamine-N5) methyltransferase activity
GXP74_RS33990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GXP74_RS33995	COG0254	rRNA binding
GXP74_RS34010	COG0083	homoserine kinase activity
GXP74_RS34015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GXP74_RS34020	COG0460	homoserine dehydrogenase
GXP74_RS34025	COG0019	diaminopimelate decarboxylase activity
GXP74_RS34030	COG0018	arginyl-trna synthetase
GXP74_RS34035	COG0745	RESPONSE REGULATOR receiver
GXP74_RS34055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GXP74_RS34100	COG1802	Transcriptional regulator
GXP74_RS34135	COG0179	Fumarylacetoacetate (FAA) hydrolase
GXP74_RS34140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GXP74_RS34150	COG1011	Hydrolase
GXP74_RS34250	COG1070	Carbohydrate kinase
GXP74_RS34290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GXP74_RS34335	COG0745	RESPONSE REGULATOR receiver
GXP74_RS34340	COG2205	protein histidine kinase activity
GXP74_RS34345	COG0567	Dehydrogenase, E1 component
GXP74_RS34345	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXP74_RS34375	COG0604	alcohol dehydrogenase
GXP74_RS34380	COG0281	malic enzyme
GXP74_RS34430	COG1597	lipid kinase activity
GXP74_RS34440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXP74_RS34450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GXP74_RS34455	COG2182	Extracellular solute-binding protein
GXP74_RS34460	COG1472	Belongs to the glycosyl hydrolase 3 family
GXP74_RS34465	COG0395	ABC-type sugar transport system, permease component
GXP74_RS34470	COG1175	transmembrane transport
GXP74_RS34475	COG2182	Extracellular solute-binding protein
GXP74_RS34480	COG2188	Transcriptional regulator
GXP74_RS34500	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS34505	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS34510	COG1595	DNA-templated transcription, initiation
GXP74_RS34515	COG0745	RESPONSE REGULATOR receiver
GXP74_RS34520	COG2205	protein histidine kinase activity
GXP74_RS34545	COG0583	DNA-binding transcription factor activity
GXP74_RS34550	COG2814	Major facilitator Superfamily
GXP74_RS34565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GXP74_RS34565	COG1473	amidohydrolase
GXP74_RS34580	COG2009	succinate dehydrogenase
GXP74_RS34595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GXP74_RS34610	COG1686	Belongs to the peptidase S11 family
GXP74_RS34625	COG2205	protein histidine kinase activity
GXP74_RS34635	COG1295	ribonuclease BN
GXP74_RS34640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GXP74_RS34640	COG0463	Glycosyl transferase, family 2
GXP74_RS34640	COG0463	Glycosyl transferase, family 2
GXP74_RS34640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GXP74_RS34645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GXP74_RS34650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GXP74_RS34665	COG0180	Tryptophanyl-tRNA synthetase
GXP74_RS34675	COG1253	flavin adenine dinucleotide binding
GXP74_RS34680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GXP74_RS34685	COG0039	L-malate dehydrogenase activity
GXP74_RS34705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GXP74_RS34715	COG1714	RDD family
GXP74_RS34720	COG0138	bifunctional purine biosynthesis protein purh
GXP74_RS34750	COG0045	succinate-CoA ligase (ADP-forming) activity
GXP74_RS34755	COG0671	phosphoesterase, PA-phosphatase related
GXP74_RS34760	COG0277	FAD linked oxidase domain protein
GXP74_RS34775	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GXP74_RS34785	COG0714	Associated with various cellular activities
GXP74_RS34800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXP74_RS34815	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GXP74_RS34820	COG2197	response regulator
GXP74_RS34855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GXP74_RS34855	COG0519	Catalyzes the synthesis of GMP from XMP
GXP74_RS34860	COG1605	Chorismate mutase
GXP74_RS34865	COG3548	integral membrane protein
GXP74_RS34875	COG1012	belongs to the aldehyde dehydrogenase family
GXP74_RS34885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GXP74_RS34890	COG2815	serine threonine protein kinase
GXP74_RS34890	COG0515	serine threonine protein kinase
GXP74_RS34900	COG2815	serine threonine protein kinase
GXP74_RS34900	COG0515	serine threonine protein kinase
GXP74_RS34905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GXP74_RS34915	COG0516	GMP reductase activity
GXP74_RS34925	COG1595	DNA-templated transcription, initiation
GXP74_RS34930	COG2197	response regulator
GXP74_RS34950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GXP74_RS34960	COG0726	polysaccharide deacetylase
GXP74_RS34965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GXP74_RS34970	COG0456	acetyltransferase
GXP74_RS34990	COG0802	atpase or kinase
GXP74_RS35000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GXP74_RS35015	COG0736	holo-[acyl-carrier-protein] synthase activity
GXP74_RS35035	COG1072	(Pantothenic acid kinase))
GXP74_RS35040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GXP74_RS35045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GXP74_RS35050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GXP74_RS35055	COG0488	(ABC) transporter
GXP74_RS35065	COG0101	tRNA pseudouridine synthase activity
GXP74_RS35070	COG0203	ribosomal protein L17
GXP74_RS35075	COG0202	RNA polymerase activity
GXP74_RS35080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GXP74_RS35085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GXP74_RS35090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GXP74_RS35095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GXP74_RS35105	COG0563	adenylate kinase activity
GXP74_RS35115	COG0200	Binds to the 23S rRNA
GXP74_RS35125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GXP74_RS35130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GXP74_RS35135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GXP74_RS35140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GXP74_RS35145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GXP74_RS35150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GXP74_RS35155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GXP74_RS35160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GXP74_RS35165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GXP74_RS35170	COG0255	Belongs to the universal ribosomal protein uL29 family
GXP74_RS35175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GXP74_RS35180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GXP74_RS35185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GXP74_RS35190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GXP74_RS35195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GXP74_RS35205	COG0088	Forms part of the polypeptide exit tunnel
GXP74_RS35210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GXP74_RS35215	COG0051	transcription antitermination factor activity, RNA binding
GXP74_RS35245	COG1215	transferase activity, transferring glycosyl groups
GXP74_RS35275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GXP74_RS35280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GXP74_RS35285	COG0049	tRNA binding
GXP74_RS35310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GXP74_RS35315	COG0085	RNA polymerase activity
GXP74_RS35320	COG0222	ribosome binding
GXP74_RS35325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GXP74_RS35330	COG0081	regulation of translation
GXP74_RS35335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GXP74_RS35340	COG0250	Participates in transcription elongation, termination and antitermination
GXP74_RS35355	COG0436	Aminotransferase
GXP74_RS35360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GXP74_RS35365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GXP74_RS35370	COG0477	Major facilitator Superfamily
GXP74_RS35385	COG2030	dehydratase
GXP74_RS35390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GXP74_RS35425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXP74_RS35430	COG0601	transmembrane transport
GXP74_RS35465	COG1666	GTP binding
GXP74_RS35510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GXP74_RS35520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GXP74_RS35525	COG0501	Belongs to the peptidase M48B family
GXP74_RS35530	COG1007	ATP synthesis coupled electron transport
GXP74_RS35540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GXP74_RS35545	COG0713	ATP synthesis coupled electron transport
GXP74_RS35555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXP74_RS35560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GXP74_RS35565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXP74_RS35570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXP74_RS35575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXP74_RS35615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXP74_RS35665	COG3851	Histidine kinase
GXP74_RS35670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GXP74_RS35675	COG0193	aminoacyl-tRNA hydrolase activity
GXP74_RS35680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GXP74_RS35685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GXP74_RS35690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GXP74_RS35710	COG1309	transcriptional regulator
GXP74_RS35715	COG4106	trans-aconitate 2-methyltransferase activity
GXP74_RS35720	COG1846	Transcriptional regulator
GXP74_RS35730	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GXP74_RS35730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GXP74_RS35740	COG2197	response regulator
GXP74_RS35745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GXP74_RS35775	COG0477	Major facilitator Superfamily
GXP74_RS35795	COG0488	(ABC) transporter
GXP74_RS35800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GXP74_RS35805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GXP74_RS35815	COG0084	hydrolase, TatD family'
GXP74_RS35820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXP74_RS35845	COG0768	penicillin binding
GXP74_RS35850	COG2514	catechol 2,3-dioxygenase activity
GXP74_RS35860	COG2197	response regulator
GXP74_RS35865	COG4585	Histidine kinase
GXP74_RS35870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GXP74_RS35880	COG0772	Belongs to the SEDS family
GXP74_RS35925	COG2814	Major facilitator Superfamily
GXP74_RS36080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GXP74_RS36085	COG0521	Mo-molybdopterin cofactor biosynthetic process
GXP74_RS36090	COG0315	cyclic pyranopterin monophosphate synthase activity
GXP74_RS36100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GXP74_RS36110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GXP74_RS36140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GXP74_RS36170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GXP74_RS36170	COG0515	serine threonine protein kinase
GXP74_RS36175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXP74_RS36180	COG1309	transcriptional regulator
GXP74_RS36190	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS36200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXP74_RS36215	COG0640	Transcriptional regulator
GXP74_RS36220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GXP74_RS36235	COG1024	Enoyl-CoA hydratase
GXP74_RS36245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GXP74_RS36255	COG4977	sequence-specific DNA binding
GXP74_RS36260	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GXP74_RS36280	COG2252	PERMEase
GXP74_RS36290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GXP74_RS36300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GXP74_RS36305	COG1333	cytochrome c biogenesis protein
GXP74_RS36310	COG0785	Cytochrome C biogenesis protein
GXP74_RS36315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GXP74_RS36320	COG0406	alpha-ribazole phosphatase activity
GXP74_RS36325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GXP74_RS36335	COG0242	peptide deformylase activity
GXP74_RS36465	COG0515	serine threonine protein kinase
GXP74_RS36465	COG2815	serine threonine protein kinase
GXP74_RS36565	COG0113	porphobilinogen synthase activity
GXP74_RS36570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GXP74_RS36570	COG1648	precorrin-2 dehydrogenase activity
GXP74_RS36575	COG0181	hydroxymethylbilane synthase activity
GXP74_RS36580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GXP74_RS36585	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GXP74_RS36635	COG0123	including yeast histone deacetylase and acetoin utilization protein
GXP74_RS36650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXP74_RS36655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GXP74_RS36675	COG0129	dihydroxy-acid dehydratase activity
GXP74_RS36680	COG2226	methyltransferase
GXP74_RS36685	COG1082	Xylose isomerase domain protein TIM barrel
GXP74_RS36690	COG0248	Ppx GppA phosphatase
GXP74_RS36720	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GXP74_RS36735	COG1309	transcriptional regulator
GXP74_RS36780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GXP74_RS36805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GXP74_RS36815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GXP74_RS36820	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GXP74_RS36825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GXP74_RS36835	COG0318	PFAM AMP-dependent synthetase and ligase
GXP74_RS36835	COG0204	Acyl-transferase
GXP74_RS36845	COG2197	response regulator
GXP74_RS36850	COG4585	Histidine kinase
GXP74_RS36860	COG0649	NAD binding
GXP74_RS36870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GXP74_RS36900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GXP74_RS36905	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS36920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXP74_RS36935	COG0640	Transcriptional regulator
GXP74_RS36955	COG1017	nitric oxide dioxygenase activity
GXP74_RS36955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GXP74_RS36995	COG1595	DNA-templated transcription, initiation
GXP74_RS37025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GXP74_RS37030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXP74_RS37050	COG0542	response to heat
GXP74_RS37060	COG2203	Gaf domain
GXP74_RS37060	COG4585	Histidine kinase
GXP74_RS37065	COG2197	response regulator
GXP74_RS37090	COG2409	Drug exporters of the RND superfamily
GXP74_RS37100	COG1136	(ABC) transporter
GXP74_RS37100	COG0577	efflux transmembrane transporter activity
GXP74_RS37115	COG4585	Histidine kinase
GXP74_RS37165	COG0596	Alpha beta hydrolase
GXP74_RS37220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GXP74_RS37235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GXP74_RS37255	COG3842	ATPase activity
GXP74_RS37280	COG0215	cysteine-tRNA ligase activity
GXP74_RS37285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GXP74_RS37290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GXP74_RS37295	COG1329	Transcriptional regulator
GXP74_RS37305	COG0745	RESPONSE REGULATOR receiver
GXP74_RS37310	COG5002	protein histidine kinase activity
GXP74_RS37325	COG0588	phosphoglycerate mutase activity
GXP74_RS37335	COG4552	Acetyltransferase involved in intracellular survival and related
GXP74_RS37345	COG1309	transcriptional regulator
GXP74_RS37370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GXP74_RS37375	COG1335	isochorismatase
GXP74_RS37385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GXP74_RS37410	COG3655	Transcriptional regulator
GXP74_RS37440	COG3293	Transposase
GXP74_RS37455	COG1228	amidohydrolase
GXP74_RS37470	COG0823	Involved in the tonB-independent uptake of proteins
GXP74_RS37470	COG1506	peptidase
GXP74_RS37510	COG2197	response regulator
GXP74_RS37515	COG4585	Histidine kinase
GXP74_RS37525	COG1733	regulation of RNA biosynthetic process
GXP74_RS37625	COG0438	transferase activity, transferring glycosyl groups
GXP74_RS37645	COG1490	D-aminoacyl-tRNA deacylase activity
GXP74_RS37650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GXP74_RS37660	COG3485	protocatechuate 3,4-dioxygenase
GXP74_RS37705	COG0745	RESPONSE REGULATOR receiver
GXP74_RS37710	COG1609	Transcriptional regulator
GXP74_RS37715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXP74_RS37720	COG0745	RESPONSE REGULATOR receiver
GXP74_RS37730	COG2271	Major facilitator Superfamily
GXP74_RS37735	COG0456	acetyltransferase
GXP74_RS37755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GXP74_RS37770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GXP74_RS37775	COG0306	phosphate transporter
GXP74_RS37785	COG1937	Protein conserved in bacteria
GXP74_RS37805	COG0277	FAD linked oxidase domain protein
GXP74_RS37810	COG0671	phosphoesterase, PA-phosphatase related
GXP74_RS37890	COG1470	cell adhesion involved in biofilm formation
GXP74_RS37890	COG0366	Alpha amylase catalytic
GXP74_RS37895	COG2226	methyltransferase
GXP74_RS37905	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS37935	COG0579	oxidoreductase
GXP74_RS37940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GXP74_RS37975	COG1968	undecaprenyl-diphosphatase activity
GXP74_RS37995	COG5002	protein histidine kinase activity
GXP74_RS38000	COG2018	Roadblock/LC7 domain
GXP74_RS38015	COG1174	glycine betaine transport
GXP74_RS38020	COG1174	glycine betaine transport
GXP74_RS38030	COG1316	TRANSCRIPTIONal
GXP74_RS38045	COG1595	DNA-templated transcription, initiation
GXP74_RS38065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GXP74_RS38070	COG1278	Cold shock
GXP74_RS38135	COG3152	Membrane
GXP74_RS38255	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GXP74_RS38270	COG0582	viral genome integration into host DNA
GXP74_RS38325	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GXP74_RS38335	COG2124	cytochrome p450
GXP74_RS38350	COG2843	Capsule synthesis protein
GXP74_RS38355	COG2175	clavaminate synthase activity
GXP74_RS38385	COG1131	(ABC) transporter
GXP74_RS38445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GXP74_RS38450	COG3629	intracellular signal transduction
GXP74_RS38450	COG3903	Transcriptional regulator
GXP74_RS38465	COG2197	response regulator
GXP74_RS38485	COG1309	transcriptional regulator
GXP74_RS38495	COG2197	response regulator
GXP74_RS38500	COG0513	Belongs to the DEAD box helicase family
GXP74_RS38560	COG2855	membrane
GXP74_RS38570	COG2205	protein histidine kinase activity
GXP74_RS38575	COG0745	RESPONSE REGULATOR receiver
GXP74_RS38600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GXP74_RS38605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GXP74_RS38630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GXP74_RS38640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GXP74_RS38660	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS38665	COG1595	DNA-templated transcription, initiation
GXP74_RS38670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GXP74_RS38675	COG0047	phosphoribosylformylglycinamidine synthase activity
GXP74_RS38680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GXP74_RS38700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GXP74_RS38715	COG0151	Belongs to the GarS family
GXP74_RS38730	COG1802	Transcriptional regulator
GXP74_RS38760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GXP74_RS38775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GXP74_RS38790	COG0191	fructose-bisphosphate aldolase activity
GXP74_RS38795	COG0586	Pfam SNARE associated Golgi protein
GXP74_RS38800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GXP74_RS38815	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GXP74_RS38835	COG1120	ATPase activity
GXP74_RS38850	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GXP74_RS38900	COG0542	response to heat
GXP74_RS38905	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GXP74_RS38905	COG0515	serine threonine protein kinase
GXP74_RS38935	COG1362	aminopeptidase activity
GXP74_RS38940	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS39000	COG1960	acyl-CoA dehydrogenase activity
GXP74_RS39015	COG0303	'Molybdopterin
GXP74_RS39025	COG1316	TRANSCRIPTIONal
GXP74_RS39045	COG1028	Short-chain dehydrogenase reductase Sdr
GXP74_RS39045	COG3321	synthase
GXP74_RS39045	COG0604	alcohol dehydrogenase
GXP74_RS39060	COG0604	alcohol dehydrogenase
GXP74_RS39085	COG0477	Major facilitator Superfamily
GXP74_RS39115	COG0515	serine threonine protein kinase
GXP74_RS39120	COG0515	serine threonine protein kinase
GXP74_RS39140	COG0022	dehydrogenase e1 component
GXP74_RS39145	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXP74_RS39175	COG1461	Dihydroxyacetone kinase
GXP74_RS39180	COG2376	Dihydroxyacetone kinase
GXP74_RS39185	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GXP74_RS39190	COG0789	Transcriptional regulator
GXP74_RS39195	COG0484	heat shock protein binding
GXP74_RS39200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GXP74_RS39205	COG0443	Heat shock 70 kDa protein
GXP74_RS39210	COG2181	nitrate reductase activity
GXP74_RS39210	COG0247	lactate metabolic process
GXP74_RS39220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GXP74_RS39225	COG0717	Belongs to the dCTP deaminase family
GXP74_RS39305	COG0702	epimerase
GXP74_RS39340	COG1533	DNA photolyase activity
GXP74_RS39360	COG3629	intracellular signal transduction
GXP74_RS39360	COG3903	Transcriptional regulator
GXP74_RS39365	COG0667	Aldo Keto reductase
GXP74_RS39385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GXP74_RS39395	COG2197	response regulator
GXP74_RS39400	COG2203	Gaf domain
GXP74_RS39400	COG4585	Histidine kinase
GXP74_RS39440	COG1733	regulation of RNA biosynthetic process
GXP74_RS39445	COG1733	regulation of RNA biosynthetic process
GXP74_RS39460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GXP74_RS39505	COG3629	intracellular signal transduction
GXP74_RS39505	COG3903	Transcriptional regulator
GXP74_RS39525	COG2197	response regulator
GXP74_RS39530	COG4585	Histidine kinase
GXP74_RS39535	COG0577	efflux transmembrane transporter activity
GXP74_RS39535	COG1136	(ABC) transporter
GXP74_RS39625	COG1131	(ABC) transporter
GXP74_RS39630	COG2205	protein histidine kinase activity
GXP74_RS39635	COG0745	RESPONSE REGULATOR receiver
GXP74_RS39745	COG0305	Participates in initiation and elongation during chromosome replication
GXP74_RS39750	COG0534	Mate efflux family protein
GXP74_RS39760	COG0359	binds to the 23S rRNA
GXP74_RS39765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GXP74_RS39770	COG0629	single-stranded DNA binding
GXP74_RS39775	COG0360	Binds together with S18 to 16S ribosomal RNA
GXP74_RS39800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GXP74_RS39810	COG1260	myo-inositol-1-phosphate synthase
GXP74_RS39820	COG0617	tRNA 3'-terminal CCA addition
GXP74_RS39835	COG0515	serine threonine protein kinase
GXP74_RS39835	COG2815	serine threonine protein kinase
GXP74_RS39840	COG1595	DNA-templated transcription, initiation
GXP74_RS39855	COG3118	belongs to the thioredoxin family
GXP74_RS39860	COG3409	Peptidoglycan-binding domain 1 protein
GXP74_RS39860	COG0860	N-Acetylmuramoyl-L-alanine amidase
GXP74_RS39875	COG1192	Involved in chromosome partitioning
GXP74_RS39880	COG0357	Ribosomal RNA small subunit methyltransferase G
GXP74_RS39890	COG0706	membrane insertase activity
GXP74_RS39895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GXP74_RS39905	COG0230	Belongs to the bacterial ribosomal protein bL34 family