locus-tag class description GXW83_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GXW83_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GXW83_RS00015 ENOG4108J5G 6-phosphogluconate dehydrogenase GXW83_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GXW83_RS00025 ENOG4105K7N UPF0232 protein GXW83_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXW83_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXW83_RS00075 ENOG4105ZJT Cell division protein CrgA GXW83_RS00090 ENOG4108U4N (sortase) family GXW83_RS00095 ENOG4108RN7 integral membrane protein GXW83_RS00125 ENOG4105HZM Fha domain containing protein GXW83_RS00130 ENOG4105TV9 FHA Domain-Containing protein GXW83_RS00130 ENOG4105TV9 FHA Domain-Containing protein GXW83_RS00145 ENOG41069HH 4-oxalocrotonate tautomerase GXW83_RS00150 ENOG4105EYF MMPL domain protein GXW83_RS00160 ENOG4108MJI response regulator GXW83_RS00170 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GXW83_RS00175 ENOG4105J5T Amp-dependent synthetase and ligase GXW83_RS00185 ENOG4107QSN dihydrolipoamide acetyltransferase GXW83_RS00200 ENOG4108XM1 transcriptional regulator AsnC family GXW83_RS00205 ENOG4108IG5 Transcriptional regulator GXW83_RS00225 ENOG4107QTZ amino acid GXW83_RS00235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GXW83_RS00240 ENOG4105F38 ABC transporter, permease GXW83_RS00245 ENOG4105D38 putrescine abc transporter GXW83_RS00255 ENOG4105WXW Antirepressor GXW83_RS00265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GXW83_RS00295 ENOG41082T9 Membrane GXW83_RS00300 ENOG4106048 Cupin 2, conserved barrel domain protein GXW83_RS00305 ENOG4105ETU transcriptional activator (TenA GXW83_RS00315 ENOG4105DZ6 Band 7 protein GXW83_RS00325 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GXW83_RS00365 ENOG4107P2S Transcriptional regulator GXW83_RS00370 ENOG4105CIH Imidazole acetol-phosphate transaminase GXW83_RS00380 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GXW83_RS00395 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GXW83_RS00415 ENOG4105BZU Histidine kinase GXW83_RS00425 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GXW83_RS00430 ENOG4108JJ9 ABC, transporter GXW83_RS00435 ENOG4108K4B hydrolase GXW83_RS00485 ENOG4105DA5 (ABC) transporter GXW83_RS00495 ENOG4105CJ1 ABC, transporter GXW83_RS00505 ENOG4105DJ2 Major Facilitator Superfamily GXW83_RS00510 ENOG41073TP transcriptional regulator GXW83_RS00520 ENOG410667J hydrolase GXW83_RS00525 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GXW83_RS00535 ENOG4105DBE peroxidase GXW83_RS00570 ENOG4107TXC Transcriptional regulator GXW83_RS00575 ENOG4107T6F Xaa-Pro aminopeptidase GXW83_RS00595 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GXW83_RS00680 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS00685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GXW83_RS00715 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GXW83_RS00720 ENOG41082BM Transcriptional regulator, arsr family GXW83_RS00750 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GXW83_RS00770 ENOG4105EQX glucarate dehydratase GXW83_RS00780 ENOG4105M2Z protein tyrosine serine phosphatase GXW83_RS00785 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXW83_RS00795 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein GXW83_RS00805 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GXW83_RS00815 ENOG4108Z6B deaminase GXW83_RS00830 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GXW83_RS00870 ENOG4105DKQ ROK family GXW83_RS00905 ENOG4105DZ6 Band 7 protein GXW83_RS00925 ENOG4105D17 glycoside hydrolase, family 3 domain protein GXW83_RS00940 ENOG41067SE Tetr family transcriptional regulator GXW83_RS00950 ENOG4107RN3 metallophosphoesterase GXW83_RS01035 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GXW83_RS01050 ENOG4105KRQ Addiction module toxin, Txe YoeB family GXW83_RS01055 ENOG4105VTW prevent-host-death family GXW83_RS01130 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GXW83_RS01140 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GXW83_RS01195 ENOG4107ZVI PhiRv2 prophage protein GXW83_RS01205 ENOG4106CY5 excisionase GXW83_RS01210 ENOG4107T65 Integrase GXW83_RS01230 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GXW83_RS01235 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GXW83_RS01245 ENOG4105CFH Aspartokinase GXW83_RS01250 ENOG4105NAF rna polymerase sigma factor GXW83_RS01275 ENOG4105C0R drug resistance transporter emrb qaca subfamily GXW83_RS01340 ENOG4107QW8 radical SAM domain protein GXW83_RS01365 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS01400 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXW83_RS01405 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXW83_RS01435 ENOG4105BZ4 penicillin-binding protein GXW83_RS01470 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GXW83_RS01495 ENOG4105D74 hydrolase GXW83_RS01505 ENOG4108YV4 Universal stress protein GXW83_RS01510 ENOG4105CHR reductase GXW83_RS01570 ENOG4105P8F nudix hydrolase GXW83_RS01590 ENOG4105D74 hydrolase GXW83_RS01605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GXW83_RS01610 ENOG4107B2H carbonic anhydrase GXW83_RS01665 ENOG4108I5C dEAD DEAH box helicase GXW83_RS01670 ENOG4105WN5 stage II sporulation protein GXW83_RS01675 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GXW83_RS01680 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for GXW83_RS01690 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GXW83_RS01700 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GXW83_RS01705 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GXW83_RS01710 ENOG4107QRG dna polymerase iii GXW83_RS01725 ENOG4108NIW Leucine export protein LeuE GXW83_RS01780 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GXW83_RS01805 ENOG4105C0R drug resistance transporter emrb qaca subfamily GXW83_RS01810 ENOG41067TZ transcriptional regulator, MarR family GXW83_RS01815 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GXW83_RS01875 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GXW83_RS01880 ENOG4107T5V SNARE associated Golgi GXW83_RS01885 ENOG4107T5V SNARE associated Golgi GXW83_RS01905 ENOG4105ETX regulatoR GXW83_RS01910 ENOG4105EB3 Histidine kinase GXW83_RS01930 ENOG4107EEP NADH dehydrogenase (quinone) (EC 1.6.99.5) GXW83_RS02155 ENOG4107QQG Dehydrogenase GXW83_RS02165 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GXW83_RS02255 ENOG41080HT Transcriptional regulator, arsr family GXW83_RS02265 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GXW83_RS02285 ENOG4105C3M thioredoxin reductase GXW83_RS02385 ENOG4105CHR reductase GXW83_RS02420 ENOG4105DF6 Fe-S oxidoreductase GXW83_RS02445 ENOG4105DBE peroxidase GXW83_RS02455 ENOG4105CVK Glutamate decarboxylase GXW83_RS02455 ENOG4105CVK Glutamate decarboxylase GXW83_RS02505 ENOG4105C0X amino acid GXW83_RS02560 ENOG4105CDU Replicative dna helicase GXW83_RS02705 ENOG4105DQQ Major facilitator superfamily MFS_1 GXW83_RS02715 ENOG4107QZF nitrite reductase NADPH large subunit GXW83_RS02720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXW83_RS02725 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GXW83_RS02735 ENOG4105K78 MarR family Transcriptional regulator GXW83_RS02750 ENOG410834F Transcriptional regulator GXW83_RS02755 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GXW83_RS02770 ENOG4107ZVI PhiRv2 prophage protein GXW83_RS02835 ENOG4107QMH DNA methylase GXW83_RS02845 ENOG4105D5G Transposase GXW83_RS02865 ENOG4105VTR Integrase GXW83_RS02905 ENOG4107T65 Integrase GXW83_RS02960 ENOG41085W3 Transposase GXW83_RS02975 ENOG41085W3 Transposase GXW83_RS03005 ENOG4107TB5 TRANSCRIPTIONal GXW83_RS03015 ENOG4108X7A Terpene synthase metal-binding domain-containing protein GXW83_RS03025 ENOG41080RH Thioredoxin GXW83_RS03060 ENOG4105ZXU NLP P60 protein GXW83_RS03065 ENOG4105F0N pyrophosphate phospho-hydrolase GXW83_RS03080 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GXW83_RS03095 ENOG4105EUJ GTP cyclohydrolase i GXW83_RS03110 ENOG4105CRK lysyL-tRNA synthetase GXW83_RS03115 ENOG4105EEI dihydropteroate synthase GXW83_RS03150 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) GXW83_RS03165 ENOG4105ESN nucleotide-binding protein GXW83_RS03190 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GXW83_RS03200 ENOG4105BZU Histidine kinase GXW83_RS03210 ENOG4105CI2 imidazolone-5-propionate hydrolase GXW83_RS03260 ENOG4105C3Q Glycosyl transferase, family 2 GXW83_RS03305 ENOG4105EEM helicase GXW83_RS03320 ENOG4105CFI type iii restriction protein res subunit GXW83_RS03380 ENOG4105VEQ Cold shock protein GXW83_RS03385 ENOG4105E63 Pfam:DUF178 GXW83_RS03390 ENOG4108UIH futalosine nucleosidase GXW83_RS03400 ENOG4108N0W Major Facilitator superfamily GXW83_RS03425 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GXW83_RS03430 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GXW83_RS03435 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS03440 ENOG4105BZU Histidine kinase GXW83_RS03455 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GXW83_RS03460 ENOG4108VVK transcriptional Regulator, AsnC GXW83_RS03465 ENOG4105C7B Threonine dehydratase GXW83_RS03470 ENOG4105DVY radical SAM domain protein GXW83_RS03485 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GXW83_RS03495 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GXW83_RS03540 ENOG4108SU4 UPF0309 protein GXW83_RS03580 ENOG4105K6V RNA polymerase GXW83_RS03590 ENOG4105K64 Glycosyl transferase, family 2 GXW83_RS03615 ENOG4105CC9 acyl-Coa dehydrogenase GXW83_RS03640 ENOG4105CC9 acyl-Coa dehydrogenase GXW83_RS03650 ENOG4107QPD alcohol dehydrogenase GXW83_RS03685 ENOG4105VEQ Cold shock protein GXW83_RS03690 ENOG4105EV6 Pfam:DUF178 GXW83_RS03695 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GXW83_RS03705 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXW83_RS03725 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS03730 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GXW83_RS03735 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS03745 ENOG4107QIZ NADH dehydrogenase GXW83_RS03750 ENOG4108IEH NADH dehydrogenase subunit g GXW83_RS03755 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GXW83_RS03760 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS03765 ENOG4105DF2 NADH dehydrogenase subunit j GXW83_RS03770 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS03775 ENOG4105D65 subunit l GXW83_RS03785 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS03800 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GXW83_RS03805 ENOG4105DQU oxidoreductase, subunit beta GXW83_RS03810 ENOG4105C0X amino acid GXW83_RS03845 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) GXW83_RS03875 ENOG4105DZ1 carboxypeptidase GXW83_RS03900 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS03905 ENOG4105BZU Histidine kinase GXW83_RS03980 ENOG4105EGI Transcriptional regulator GXW83_RS03995 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GXW83_RS04045 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GXW83_RS04050 ENOG4105ECQ AraC Family Transcriptional Regulator GXW83_RS04055 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GXW83_RS04070 ENOG4108W8B Beta-lactamase domain protein GXW83_RS04100 ENOG4105NAF rna polymerase sigma factor GXW83_RS04130 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS04140 ENOG4107WI4 Aldose-1-epimerase GXW83_RS04150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXW83_RS04155 ENOG4105BZU Histidine kinase GXW83_RS04160 ENOG4105EDW glycosyl transferase, family 39 GXW83_RS04160 ENOG4105EDW glycosyl transferase, family 39 GXW83_RS04180 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GXW83_RS04185 ENOG4106A3M Cytochrome p-450 GXW83_RS04195 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GXW83_RS04245 ENOG4105CHU acetyl-coa acetyltransferase GXW83_RS04270 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GXW83_RS04305 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GXW83_RS04335 ENOG41086VY Fic/DOC family GXW83_RS04355 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GXW83_RS04370 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GXW83_RS04375 ENOG4105C7B Threonine dehydratase GXW83_RS04395 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GXW83_RS04405 ENOG4105T1M mycothiol conjugate amidase mca GXW83_RS04415 ENOG4105D9G High-affinity GXW83_RS04435 ENOG4105ECY inositol monophosphatase GXW83_RS04450 ENOG4107TXC Transcriptional regulator GXW83_RS04465 ENOG4105C7Z Conserved Protein GXW83_RS04475 ENOG4105C57 major facilitator superfamily GXW83_RS04485 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) GXW83_RS04495 ENOG4105CHM Aminotransferase GXW83_RS04520 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) GXW83_RS04530 ENOG4105CPC Aldo Keto reductase GXW83_RS04535 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GXW83_RS04540 ENOG4108IAB Phoh family GXW83_RS04555 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GXW83_RS04560 ENOG4105D3R alkyl hydroperoxide reductase GXW83_RS04580 ENOG4105EUB pirin domain protein GXW83_RS04590 ENOG4105C9Q fumarate hydratase class II GXW83_RS04620 ENOG4107GFK fumarate GXW83_RS04645 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) GXW83_RS04655 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GXW83_RS04660 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GXW83_RS04675 ENOG4105C3G gtp-binding protein GXW83_RS04705 ENOG4105M6F mutator MutT protein GXW83_RS04725 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GXW83_RS04745 ENOG4105CI3 gtp-binding protein typa GXW83_RS04755 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXW83_RS04760 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXW83_RS04770 ENOG4108JQ7 (ABC) transporter GXW83_RS04805 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GXW83_RS04820 ENOG4108762 serine threonine protein kinase GXW83_RS04825 ENOG4108M15 ABC transporter GXW83_RS04835 ENOG4105BZU Histidine kinase GXW83_RS04850 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GXW83_RS04855 ENOG4108Z4U Ferredoxin GXW83_RS04875 ENOG4107R4C succinyl-diaminopimelate desuccinylase GXW83_RS04880 ENOG4108URH decarboxylase GXW83_RS04885 ENOG4105EEI dihydropteroate synthase GXW83_RS04890 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GXW83_RS04895 ENOG4105CGU Enoyl-CoA hydratase GXW83_RS04920 ENOG4105C0H protease GXW83_RS04925 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GXW83_RS04935 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GXW83_RS04950 ENOG4105CJW magnesium transporter GXW83_RS04975 ENOG4105DB7 PHP domain protein GXW83_RS04995 ENOG4105C1J atp-dependent rna helicase GXW83_RS05035 ENOG4105CPK Glycosyl transferase (Group 1 GXW83_RS05070 ENOG4105C4R Atp-dependent dna helicase GXW83_RS05100 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GXW83_RS05110 ENOG4105FDP GntR family transcriptional regulator GXW83_RS05130 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXW83_RS05140 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GXW83_RS05180 ENOG41063PX domain protein GXW83_RS05215 ENOG4107TK4 histidinol-phosphate phosphatase GXW83_RS05220 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GXW83_RS05230 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GXW83_RS05235 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GXW83_RS05245 ENOG4108RAV Conserved protein GXW83_RS05250 ENOG4105EMN RNA polymerase sigma factor GXW83_RS05255 ENOG4105WMN AntiSigma factor GXW83_RS05265 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXW83_RS05280 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GXW83_RS05285 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GXW83_RS05305 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GXW83_RS05325 ENOG4105E98 transcriptional regulator DeoR family GXW83_RS05330 ENOG4108JIK carboxylase GXW83_RS05345 ENOG4107WR6 Maf-like protein GXW83_RS05355 ENOG4105D8K carboxyl transferase GXW83_RS05360 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GXW83_RS05365 ENOG4108QER Adenylate cyclase GXW83_RS05370 ENOG4105KDM Diguanylate cyclase with gaf sensor GXW83_RS05375 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GXW83_RS05380 ENOG4105C84 Histidine ammonia-lyase GXW83_RS05400 ENOG4105CGP Urocanate hydratase GXW83_RS05405 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GXW83_RS05415 ENOG4105CI2 imidazolone-5-propionate hydrolase GXW83_RS05420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXW83_RS05425 ENOG41065SU Two-component system sensor kinase GXW83_RS05450 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GXW83_RS05455 ENOG4105K4P CoA-binding domain protein GXW83_RS05460 ENOG4105C6Y Udp-glucose 6-dehydrogenase GXW83_RS05475 ENOG4105C84 Histidine ammonia-lyase GXW83_RS05485 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GXW83_RS05510 ENOG4105FDP GntR family transcriptional regulator GXW83_RS05525 ENOG4107TB5 TRANSCRIPTIONal GXW83_RS05555 ENOG4105EB3 Histidine kinase GXW83_RS05560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXW83_RS05570 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXW83_RS05575 ENOG4107RGC Glycosyl transferase, family 2 GXW83_RS05595 ENOG4107QKV phosphomannomutase GXW83_RS05600 ENOG4105W49 UPF0434 protein GXW83_RS05610 ENOG4105EIP mannose-6-phosphate isomerase GXW83_RS05620 ENOG4105K8R UPF0145 protein GXW83_RS05630 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GXW83_RS05655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXW83_RS05660 ENOG4105BZU Histidine kinase GXW83_RS05665 ENOG4105G3P Lipoprotein lpqB GXW83_RS05670 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GXW83_RS05675 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GXW83_RS05680 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS05685 ENOG4105T0Z Conserved Protein GXW83_RS05690 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GXW83_RS05710 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GXW83_RS05730 ENOG4105C7I Dehydrogenase GXW83_RS05735 ENOG4105EC2 ftsk spoIIIe GXW83_RS05740 ENOG4108UGD Serine Threonine protein kinase GXW83_RS05745 ENOG4108QVN serine threonine protein kinase GXW83_RS05750 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) GXW83_RS05765 ENOG4105CAK Cell division ATP-binding protein ftsE GXW83_RS05775 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GXW83_RS05790 ENOG4105EEM helicase GXW83_RS05800 ENOG4108426 dNA-binding protein GXW83_RS05805 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GXW83_RS05810 ENOG4108UJU UPF0301 protein GXW83_RS05820 ENOG4105E2D ec 3.2.1.52 GXW83_RS05870 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GXW83_RS05875 ENOG4105CQB FAD linked oxidase domain protein GXW83_RS05890 ENOG4105BZU Histidine kinase GXW83_RS05895 ENOG4105CYP glycoside hydrolase, family GXW83_RS05905 ENOG4105KF0 sporulation and cell division protein, SsgA GXW83_RS05930 ENOG4108RWI nicotinamidase GXW83_RS05940 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GXW83_RS05970 ENOG4108RQ5 Beta-lactamase domain-containing protein GXW83_RS05985 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GXW83_RS05990 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GXW83_RS06025 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GXW83_RS06030 ENOG4105BZ4 penicillin-binding protein GXW83_RS06050 ENOG4105E2D ec 3.2.1.52 GXW83_RS06060 ENOG4106BRA Membrane GXW83_RS06065 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GXW83_RS06070 ENOG4105MWK D-amino acid dehydrogenase, small subunit GXW83_RS06075 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GXW83_RS06100 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GXW83_RS06130 ENOG4105CN5 Metallo-Beta-Lactamase GXW83_RS06135 ENOG4105C0X amino acid GXW83_RS06160 ENOG4105D8K carboxyl transferase GXW83_RS06170 ENOG4106UDK Cellulose-binding, family II GXW83_RS06175 ENOG4105K6H D-cysteine desulfhydrase GXW83_RS06180 ENOG4105DEN Luciferase family GXW83_RS06195 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GXW83_RS06215 ENOG4105BZU Histidine kinase GXW83_RS06220 ENOG4108NJZ Sensory box GGDEF EAL domain protein GXW83_RS06260 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GXW83_RS06275 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GXW83_RS06285 ENOG4105C5S asparaginyl-tRNA synthetase GXW83_RS06295 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GXW83_RS06300 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GXW83_RS06375 ENOG4108ZM9 phosphoglycerate mutase GXW83_RS06380 ENOG4105D9R oxidoreductase GXW83_RS06410 ENOG4105C3U ABC transporter GXW83_RS06415 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXW83_RS06420 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXW83_RS06425 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS06440 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS06460 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GXW83_RS06470 ENOG4105PAD Hydrolase GXW83_RS06480 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS06485 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GXW83_RS06495 ENOG4107QX3 carboxylase GXW83_RS06505 ENOG410905P Pyridoxamine 5-phosphate GXW83_RS06540 ENOG4106KR7 LysR family Transcriptional regulator GXW83_RS06550 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GXW83_RS06560 ENOG4108V06 Glutathione peroxidase GXW83_RS06565 ENOG4105C7H Helicase, RecD TraA family GXW83_RS06600 ENOG4105Y3U Transglycosylase-associated protein GXW83_RS06630 ENOG410834F Transcriptional regulator GXW83_RS06635 ENOG4105CQ7 ATP-dependent helicase GXW83_RS06640 ENOG41068WN GXW83_RS06650 ENOG4108Z6Z Transcriptional regulator GXW83_RS06670 ENOG4105VHU single-stranded DNA-binding protein GXW83_RS06690 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GXW83_RS06695 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GXW83_RS06710 ENOG4108K81 inner membrane protein YghB GXW83_RS06740 ENOG4105DEN Luciferase family GXW83_RS06770 ENOG4105VEQ Cold shock protein GXW83_RS06780 ENOG4105K5B UPF0225 protein GXW83_RS06790 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GXW83_RS06825 ENOG4105CT1 (ABC) transporter GXW83_RS06835 ENOG410825M Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GXW83_RS06850 ENOG4105F8D glycoside hydrolase family 4 GXW83_RS06860 ENOG4105D8X mechanosensitive ion channel GXW83_RS06895 ENOG4105MC2 DSBA oxidoreductase GXW83_RS06900 ENOG4107ZYJ bioY protein GXW83_RS06905 ENOG4108YZG isomerase GXW83_RS06930 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GXW83_RS07020 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GXW83_RS07025 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GXW83_RS07030 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GXW83_RS07035 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GXW83_RS07040 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GXW83_RS07050 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GXW83_RS07060 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GXW83_RS07065 ENOG4105DFF Rod shape-determining protein mreb GXW83_RS07080 ENOG4105CJN penicillin-binding protein GXW83_RS07085 ENOG4105CNI cell division protein FtsW GXW83_RS07160 ENOG4105C03 ribonuclease GXW83_RS07165 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GXW83_RS07170 ENOG4105K46 50S ribosomal protein l27 GXW83_RS07175 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GXW83_RS07185 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GXW83_RS07195 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GXW83_RS07210 ENOG4105D0M Protease HtpX homolog GXW83_RS07225 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GXW83_RS07240 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GXW83_RS07275 ENOG4107QQG Dehydrogenase GXW83_RS07295 ENOG4105C8T Leucyl-tRNA synthetase GXW83_RS07305 ENOG4105EPR degv family GXW83_RS07330 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GXW83_RS07335 ENOG41061CK Antibiotic biosynthesis monooxygenase GXW83_RS07345 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GXW83_RS07395 ENOG4105D0M Protease HtpX homolog GXW83_RS07400 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GXW83_RS07405 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GXW83_RS07415 ENOG4107RE3 peptidase, S41 GXW83_RS07420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GXW83_RS07425 ENOG4108KTQ Methyltransferase GXW83_RS07430 ENOG4107YU2 histidine triad (hIT) protein GXW83_RS07435 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GXW83_RS07445 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GXW83_RS07480 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GXW83_RS07485 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS07490 ENOG4108J2P Alpha beta hydrolase fold GXW83_RS07495 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GXW83_RS07505 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GXW83_RS07515 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GXW83_RS07520 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GXW83_RS07530 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GXW83_RS07570 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GXW83_RS07595 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GXW83_RS07605 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GXW83_RS07610 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXW83_RS07660 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GXW83_RS07685 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GXW83_RS07690 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXW83_RS07710 ENOG4107S1E Beta-lactamase GXW83_RS07715 ENOG4105VUF Transcriptional regulator GXW83_RS07720 ENOG4105CPC Aldo Keto reductase GXW83_RS07735 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GXW83_RS07770 ENOG4105E2R ROK family GXW83_RS07795 ENOG4105DAX Pfam:DUF2983 GXW83_RS07835 ENOG4105CYP glycoside hydrolase, family GXW83_RS07845 ENOG4105D9P serine threonine protein kinase GXW83_RS07855 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GXW83_RS07860 ENOG4105CF1 Alkylated DNA repair protein GXW83_RS07895 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GXW83_RS07910 ENOG4105CPC Aldo Keto reductase GXW83_RS07930 ENOG4106A3M Cytochrome p-450 GXW83_RS07935 ENOG4105F2C Acetyl-CoA acetyltransferase GXW83_RS07970 ENOG4108SGK Tetr family transcriptional regulator GXW83_RS07975 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GXW83_RS07980 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXW83_RS07995 ENOG4105DYW oxidoreductase GXW83_RS08005 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GXW83_RS08065 ENOG4105E5G Alpha beta hydrolase fold GXW83_RS08070 ENOG4105EGD dinuclear metal center protein, YbgI family GXW83_RS08085 ENOG4107XFJ UPF0246 protein GXW83_RS08090 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GXW83_RS08145 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GXW83_RS08180 ENOG4105PAD Hydrolase GXW83_RS08285 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GXW83_RS08350 ENOG4105C5S asparaginyl-tRNA synthetase GXW83_RS08360 ENOG4108Z4U Ferredoxin GXW83_RS08370 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS08375 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GXW83_RS08410 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GXW83_RS08445 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GXW83_RS08455 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GXW83_RS08480 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GXW83_RS08495 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GXW83_RS08505 ENOG4105EGE secreted protein GXW83_RS08510 ENOG4106UDK Cellulose-binding, family II GXW83_RS08515 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS08530 ENOG41060H3 Protein of unknown function (DUF1049) GXW83_RS08535 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GXW83_RS08590 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GXW83_RS08620 ENOG4107XZ0 Peptidase M50 GXW83_RS08665 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GXW83_RS08710 ENOG4105BZ4 penicillin-binding protein GXW83_RS08715 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GXW83_RS08725 ENOG4105C4K Nad synthetase GXW83_RS08730 ENOG4105C5F glutamine synthetase GXW83_RS08745 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GXW83_RS08755 ENOG4106HK8 GPR1 FUN34 yaaH family protein GXW83_RS08785 ENOG4105HSS phospholipase C GXW83_RS08820 ENOG4107XEY Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GXW83_RS08825 ENOG4108KPJ rna polymerase sigma factor GXW83_RS08860 ENOG4105KRQ Addiction module toxin, Txe YoeB family GXW83_RS08865 ENOG4105VTW prevent-host-death family GXW83_RS08895 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GXW83_RS08900 ENOG4108FN7 Aldo keto reductase GXW83_RS08905 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GXW83_RS08945 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GXW83_RS08950 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GXW83_RS08955 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GXW83_RS08960 ENOG4108YZT Adenosylcobinamide kinase GXW83_RS08975 ENOG4105CPC Aldo Keto reductase GXW83_RS08980 ENOG4105DXX methyltransferase GXW83_RS09000 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GXW83_RS09010 ENOG4105F7P transcriptional regulator AsnC family GXW83_RS09015 ENOG4105DY8 decarboxylase GXW83_RS09040 ENOG4107T4Z adenosine kinase GXW83_RS09050 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GXW83_RS09055 ENOG4105BZ9 Cytochrome C oxidase, subunit I GXW83_RS09060 ENOG4105MCD Part of cytochrome c oxidase, its function is GXW83_RS09065 ENOG4107UBC ErfK ybiS ycfS ynhG family protein GXW83_RS09070 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GXW83_RS09075 ENOG4107EUI c reductase, iron-sulfur GXW83_RS09085 ENOG4105CCU oxidase (Subunit III) GXW83_RS09095 ENOG4108I0Q anthranilate phosphoribosyltransferase GXW83_RS09100 ENOG4105C9B Cysteine desulfurase GXW83_RS09130 ENOG4105K4H Nlp p60 protein GXW83_RS09150 ENOG4105JNK Glycosyl transferase (Group 1 GXW83_RS09170 ENOG4105D0U Arsenite-activated ATPase (ArsA) GXW83_RS09180 ENOG4105DKQ ROK family GXW83_RS09210 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS09215 ENOG4105CTQ phosphohexokinase GXW83_RS09220 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GXW83_RS09230 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GXW83_RS09240 ENOG4108UQY Iron-storage protein GXW83_RS09265 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GXW83_RS09280 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase GXW83_RS09290 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GXW83_RS09315 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GXW83_RS09325 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GXW83_RS09330 ENOG4108VW9 Membrane GXW83_RS09340 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GXW83_RS09360 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GXW83_RS09370 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GXW83_RS09380 ENOG4105CJN penicillin-binding protein GXW83_RS09385 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GXW83_RS09390 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GXW83_RS09395 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GXW83_RS09400 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GXW83_RS09410 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GXW83_RS09420 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GXW83_RS09425 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GXW83_RS09430 ENOG4105DFA alanine racemase domain protein GXW83_RS09435 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GXW83_RS09445 ENOG4107VQS DivIVA family GXW83_RS09450 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GXW83_RS09460 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GXW83_RS09500 ENOG4105C0B DNA polymerase III (alpha subunit) GXW83_RS09530 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GXW83_RS09535 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GXW83_RS09540 ENOG4105CIH Imidazole acetol-phosphate transaminase GXW83_RS09545 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GXW83_RS09555 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GXW83_RS09560 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GXW83_RS09565 ENOG4108176 endoribonuclease L-psp GXW83_RS09570 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GXW83_RS09580 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GXW83_RS09585 ENOG4105CRQ synthase (Component I) GXW83_RS09605 ENOG4105DK0 Indole-3-glycerol phosphate synthase GXW83_RS09615 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GXW83_RS09620 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GXW83_RS09640 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS09645 ENOG4105ENE Histidine kinase GXW83_RS09655 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GXW83_RS09670 ENOG4105CBC glutamate synthase GXW83_RS09685 ENOG4105DBE peroxidase GXW83_RS09700 ENOG4107QTZ amino acid GXW83_RS09705 ENOG4107QTZ amino acid GXW83_RS09720 ENOG4105KA0 thioesterase Superfamily protein GXW83_RS09730 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXW83_RS09740 ENOG4107R13 MMPL domain protein GXW83_RS09745 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GXW83_RS09815 ENOG4105EYF MMPL domain protein GXW83_RS09830 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GXW83_RS09835 ENOG4108IY8 ABC, transporter GXW83_RS09860 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GXW83_RS09870 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GXW83_RS09875 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GXW83_RS09880 ENOG4105CFC Transporter GXW83_RS09895 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GXW83_RS09915 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GXW83_RS09940 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GXW83_RS09975 ENOG4105KZX Pterin carbinolamine dehydratase GXW83_RS09980 ENOG4105VF7 tolerance protein GXW83_RS09985 ENOG4105DWY Agmatine deiminase GXW83_RS09990 ENOG4105CQM Urea amidohydrolase subunit alpha GXW83_RS10030 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXW83_RS10040 ENOG4107HP6 Transcriptional regulator GXW83_RS10045 ENOG4107R9S Malate synthase GXW83_RS10060 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GXW83_RS10085 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GXW83_RS10090 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GXW83_RS10095 ENOG41060W2 glyoxylate carboligase GXW83_RS10100 ENOG4105BZW Glycerate kinase GXW83_RS10135 ENOG4105C7N Xanthine uracil vitamin C permease GXW83_RS10155 ENOG4105DGW oligopeptidase A GXW83_RS10165 ENOG4105DKQ ROK family GXW83_RS10175 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GXW83_RS10180 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN GXW83_RS10195 ENOG4108TCJ secreted hydrolase GXW83_RS10285 ENOG4105D56 permease protein GXW83_RS10290 ENOG4105EG2 ABC transporter, permease GXW83_RS10295 ENOG4105CG3 alpha amylase, catalytic region GXW83_RS10355 ENOG4108ZJ4 polysaccharide deacetylase GXW83_RS10400 ENOG4108WYP Transcriptional regulator GXW83_RS10410 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GXW83_RS10415 ENOG4105CXT aspartate transcarbamylase GXW83_RS10420 ENOG4105CD3 dihydroorotase GXW83_RS10430 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GXW83_RS10435 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GXW83_RS10440 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GXW83_RS10445 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GXW83_RS10450 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GXW83_RS10455 ENOG4105SKN orotidine 5''-phosphate decarboxylase GXW83_RS10465 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GXW83_RS10480 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GXW83_RS10485 ENOG41082VC UPF0145 protein GXW83_RS10500 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXW83_RS10505 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GXW83_RS10515 ENOG4105DJV ribulose-phosphate 3-epimerase GXW83_RS10550 ENOG4108Z66 YbaK ebsC protein GXW83_RS10555 ENOG4105BZU Histidine kinase GXW83_RS10575 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GXW83_RS10580 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GXW83_RS10585 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase GXW83_RS10590 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GXW83_RS10610 ENOG4108IUX (ABC) transporter GXW83_RS10630 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS10650 ENOG4105EW9 transcriptional regulator AsnC family GXW83_RS10670 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GXW83_RS10680 ENOG4105Q70 GXW83_RS10685 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GXW83_RS10715 ENOG4105EJ2 Transcriptional regulator GXW83_RS10730 ENOG4105EX0 alpha-galactosidase GXW83_RS10745 ENOG4105CGK Exodeoxyribonuclease III GXW83_RS10765 ENOG4105C5H ABC transporter GXW83_RS10770 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GXW83_RS10790 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GXW83_RS10965 ENOG4105C26 Dehydrogenase GXW83_RS11035 ENOG4108YYC ycei family GXW83_RS11040 ENOG4108VCA G U mismatch-specific DNA glycosylase GXW83_RS11050 ENOG41067TZ transcriptional regulator, MarR family GXW83_RS11055 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GXW83_RS11080 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GXW83_RS11085 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GXW83_RS11115 ENOG4105CGK Exodeoxyribonuclease III GXW83_RS11165 ENOG4105C8Y Acetylornithine aminotransferase GXW83_RS11170 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) GXW83_RS11190 ENOG4106A3M Cytochrome p-450 GXW83_RS11225 ENOG4108SGK Tetr family transcriptional regulator GXW83_RS11230 ENOG4105C29 acyl-CoA thioesterase GXW83_RS11245 ENOG4105DY8 decarboxylase GXW83_RS11250 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GXW83_RS11260 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GXW83_RS11275 ENOG4105E9K Isocitrate dehydrogenase GXW83_RS11280 ENOG4108Z0R Transferase GXW83_RS11285 ENOG4105FDP GntR family transcriptional regulator GXW83_RS11290 ENOG4105DKQ ROK family GXW83_RS11305 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GXW83_RS11310 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GXW83_RS11315 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GXW83_RS11355 ENOG4105C5I Dehydrogenase GXW83_RS11360 ENOG4105CTQ phosphohexokinase GXW83_RS11365 ENOG4105F1K Glutamine amidotransferase GXW83_RS11370 ENOG4105DMS mur ligase GXW83_RS11375 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXW83_RS11385 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS11420 ENOG4105CHU acetyl-coa acetyltransferase GXW83_RS11425 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS11440 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GXW83_RS11460 ENOG4105C57 major facilitator superfamily GXW83_RS11475 ENOG4105U5Y Transcriptional regulator GXW83_RS11490 ENOG4105DE4 1-phosphofructokinase GXW83_RS11495 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GXW83_RS11505 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GXW83_RS11510 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GXW83_RS11515 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GXW83_RS11525 ENOG4105BZ1 (ABC) transporter GXW83_RS11540 ENOG4105PGM cation diffusion facilitator family transporter GXW83_RS11610 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GXW83_RS11620 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GXW83_RS11645 ENOG4105JAB phenazine biosynthesis protein, phzf family GXW83_RS11655 ENOG4105NTW Transcriptional regulator GXW83_RS11665 ENOG4108UW5 maltose o-acetyltransferase GXW83_RS11670 ENOG4106UW1 Major Facilitator superfamily GXW83_RS11700 ENOG4105MVE transcriptional regulator GXW83_RS11710 ENOG4106F1P AAA ATPase, central domain protein GXW83_RS11735 ENOG4105C3R Methionine synthase GXW83_RS11740 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GXW83_RS11780 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) GXW83_RS11785 ENOG4105E5F proteasome GXW83_RS11790 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) GXW83_RS11800 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GXW83_RS11805 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) GXW83_RS11810 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) GXW83_RS11815 ENOG4108V1T peptidylprolyl cis-trans isomerase GXW83_RS11845 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GXW83_RS11850 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GXW83_RS11880 ENOG4105WKW Pfam:DUF1458 GXW83_RS11890 ENOG4105D29 Helix-turn-helix type 11 domain protein GXW83_RS11900 ENOG4105HFS 5'-3' exonuclease GXW83_RS11910 ENOG4108Z86 Glutamine amidotransferase GXW83_RS11930 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GXW83_RS12000 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GXW83_RS12005 ENOG41084BS 50S ribosomal protein L35 GXW83_RS12010 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GXW83_RS12015 ENOG4108RWN rrna methyltransferase GXW83_RS12020 ENOG4105BZU Histidine kinase GXW83_RS12025 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GXW83_RS12030 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GXW83_RS12035 ENOG41066UM arsR family transcriptional regulator GXW83_RS12050 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GXW83_RS12055 ENOG4107VIJ nudix hydrolase GXW83_RS12065 ENOG4105E98 transcriptional regulator DeoR family GXW83_RS12070 ENOG4105C0B DNA polymerase III (alpha subunit) GXW83_RS12075 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GXW83_RS12090 ENOG4105CHR reductase GXW83_RS12095 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GXW83_RS12100 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GXW83_RS12105 ENOG4105CAS nag kinase GXW83_RS12110 ENOG4105C8Y Acetylornithine aminotransferase GXW83_RS12115 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GXW83_RS12120 ENOG4105CDH Citrulline--aspartate ligase GXW83_RS12125 ENOG4105CH7 arginosuccinase GXW83_RS12150 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GXW83_RS12155 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GXW83_RS12165 ENOG4108762 serine threonine protein kinase GXW83_RS12230 ENOG4105KF0 sporulation and cell division protein, SsgA GXW83_RS12245 ENOG4108JDX DNA polymerase iii, epsilon subunit GXW83_RS12260 ENOG4105C22 threonyL-tRNA synthetase GXW83_RS12290 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase GXW83_RS12295 ENOG4105E2K Glycosyl transferase (Group 1 GXW83_RS12305 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GXW83_RS12310 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GXW83_RS12315 ENOG4105CDY transcriptional regulatory protein GXW83_RS12320 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GXW83_RS12325 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GXW83_RS12330 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GXW83_RS12340 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GXW83_RS12345 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GXW83_RS12350 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GXW83_RS12355 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GXW83_RS12360 ENOG4105C99 atpase involved in dna repair GXW83_RS12365 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) GXW83_RS12375 ENOG4105CUT histidyl-tRNA synthetase GXW83_RS12380 ENOG4105C9M aspartyl-trna synthetase GXW83_RS12415 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GXW83_RS12435 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GXW83_RS12440 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GXW83_RS12450 ENOG4105E2X shikimate dehydrogenase GXW83_RS12455 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GXW83_RS12460 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GXW83_RS12465 ENOG4105D49 3-dehydroquinate synthase GXW83_RS12470 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GXW83_RS12480 ENOG4105DC7 peptidase M24 GXW83_RS12485 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GXW83_RS12490 ENOG410803B Involved in the transcription termination process (By similarity) GXW83_RS12515 ENOG4108IXY short-chain dehydrogenase reductase GXW83_RS12540 ENOG4105CRK lysyL-tRNA synthetase GXW83_RS12545 ENOG4105BZU Histidine kinase GXW83_RS12550 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS12650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GXW83_RS12655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXW83_RS12660 ENOG4105C3U ABC transporter GXW83_RS12685 ENOG4105CVK Glutamate decarboxylase GXW83_RS12690 ENOG4108JGH Tetr family transcriptional regulator GXW83_RS12700 ENOG4105EY8 ABC transporter GXW83_RS12705 ENOG4105FE1 phytoene synthase GXW83_RS12715 ENOG4107S11 squalene-associated FAD-dependent desaturase GXW83_RS12735 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GXW83_RS12755 ENOG410841Q phosphoesterase PA-phosphatase related protein GXW83_RS12780 ENOG4108IG5 Transcriptional regulator GXW83_RS12800 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS12835 ENOG4105F95 Monooxygenase GXW83_RS12845 ENOG4105CV8 reductase GXW83_RS12860 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GXW83_RS12865 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GXW83_RS12890 ENOG4105CXK mandelate racemase muconate lactonizing GXW83_RS12895 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GXW83_RS12900 ENOG4105CHR reductase GXW83_RS12910 ENOG4106P37 HTH-type transcriptional regulator YjhI GXW83_RS12920 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GXW83_RS12935 ENOG41069M3 Transcriptional regulator GXW83_RS12945 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GXW83_RS12975 ENOG4105CPC Aldo Keto reductase GXW83_RS12980 ENOG4105DYW oxidoreductase GXW83_RS12990 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GXW83_RS12995 ENOG41061ZR Transcriptional regulator GXW83_RS12995 ENOG41061ZR Transcriptional regulator GXW83_RS13010 ENOG4105E6M Sulphatase-modifying factor protein GXW83_RS13030 ENOG4107R13 MMPL domain protein GXW83_RS13075 ENOG4105C8N cysteinyl-tRNA synthetase GXW83_RS13085 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GXW83_RS13090 ENOG4105DMF Dehydrogenase GXW83_RS13130 ENOG4105X7H acyl-CoA dehydrogenase GXW83_RS13185 ENOG4105C83 adenylosuccinate lyase GXW83_RS13210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GXW83_RS13245 ENOG4106W5V Membrane GXW83_RS13265 ENOG4105CPP Dehydrogenase, E1 component GXW83_RS13270 ENOG4107R0V Pyruvate dehydrogenase GXW83_RS13300 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GXW83_RS13320 ENOG4108KQJ Type 11 methyltransferase GXW83_RS13345 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXW83_RS13350 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GXW83_RS13390 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GXW83_RS13400 ENOG4105CV8 reductase GXW83_RS13435 ENOG4105EZR dyp-type peroxidase family protein GXW83_RS13440 ENOG4105DFF Rod shape-determining protein mreb GXW83_RS13475 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GXW83_RS13485 ENOG4108MJI response regulator GXW83_RS13495 ENOG4107QTZ amino acid GXW83_RS13505 ENOG4108IPT Naphthoate synthase GXW83_RS13530 ENOG4105CWX Alpha-1,2-mannosidase GXW83_RS13540 ENOG4105CHU acetyl-coa acetyltransferase GXW83_RS13545 ENOG410846T CoA-transferase family III GXW83_RS13565 ENOG41082YX Transcriptional regulator, arsr family GXW83_RS13600 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GXW83_RS13615 ENOG4105D5G Transposase GXW83_RS13625 ENOG4105CHR reductase GXW83_RS13655 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GXW83_RS13670 ENOG4107S5I aldo keto reductase GXW83_RS13680 ENOG4108DT4 serine threonine protein kinase GXW83_RS13710 ENOG4105EYF MMPL domain protein GXW83_RS13735 ENOG41081F0 Precorrin-8x methylmutase GXW83_RS13840 ENOG4105CS1 NAD(P)H quinone oxidoreductase GXW83_RS13845 ENOG4105KVH Transcriptional regulator GXW83_RS13865 ENOG410834F Transcriptional regulator GXW83_RS13885 ENOG4105CUB amino acid GXW83_RS13895 ENOG4105EYF MMPL domain protein GXW83_RS13900 ENOG4106NZI LysR family Transcriptional regulator GXW83_RS13930 ENOG4105EGE secreted protein GXW83_RS13935 ENOG4108ZJ4 polysaccharide deacetylase GXW83_RS13940 ENOG4108ZJ4 polysaccharide deacetylase GXW83_RS13955 ENOG4105VCT ion-transport protein YfeO GXW83_RS13970 ENOG4108UZX fmn reductase GXW83_RS13985 ENOG4105CDA abc transporter atp-binding protein GXW83_RS13995 ENOG4105E5Q amino acid AbC transporter GXW83_RS14000 ENOG4105CDA abc transporter atp-binding protein GXW83_RS14035 ENOG4105D9G High-affinity GXW83_RS14055 ENOG4108IXY short-chain dehydrogenase reductase GXW83_RS14065 ENOG4105C57 major facilitator superfamily GXW83_RS14115 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GXW83_RS14150 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GXW83_RS14180 ENOG4105DIA mandelate racemase muconate lactonizing GXW83_RS14190 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GXW83_RS14210 ENOG4105CIK Amidinotransferase GXW83_RS14225 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GXW83_RS14270 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GXW83_RS14280 ENOG4105ECB domain protein GXW83_RS14285 ENOG4108M15 ABC transporter GXW83_RS14305 ENOG4105SCY DNAK suppressor GXW83_RS14325 ENOG4105E98 transcriptional regulator DeoR family GXW83_RS14345 ENOG4105CPQ Dehydrogenase GXW83_RS14360 ENOG4107S5I aldo keto reductase GXW83_RS14380 ENOG4105DND Transcriptional regulator GXW83_RS14385 ENOG4106HB6 Alpha beta hydrolase GXW83_RS14420 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GXW83_RS14425 ENOG4108UTZ Dihydroxyacetone kinase GXW83_RS14430 ENOG4105CMT Dihydroxyacetone kinase GXW83_RS14455 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS14465 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GXW83_RS14470 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS14475 ENOG4105CNN ABC, transporter GXW83_RS14480 ENOG4107R9N ABC transporter GXW83_RS14485 ENOG4105C2J ABC transporter GXW83_RS14490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GXW83_RS14500 ENOG4108J2P Alpha beta hydrolase fold GXW83_RS14515 ENOG4105CY0 Metallo-Beta-Lactamase GXW83_RS14535 ENOG4108MP6 LysR family Transcriptional regulator GXW83_RS14565 ENOG4105C57 major facilitator superfamily GXW83_RS14590 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GXW83_RS14595 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS14600 ENOG4105BZU Histidine kinase GXW83_RS14625 ENOG41085A6 mbth domain-containing protein GXW83_RS14645 ENOG4106A3M Cytochrome p-450 GXW83_RS14650 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS14655 ENOG4105WN5 stage II sporulation protein GXW83_RS14685 ENOG4107U9T Pfam:Ribonuclease_BN GXW83_RS14705 ENOG4105CH6 catalase GXW83_RS14725 ENOG4105BZ1 (ABC) transporter GXW83_RS14745 ENOG4105EMN RNA polymerase sigma factor GXW83_RS14760 ENOG4105EC2 ftsk spoIIIe GXW83_RS14815 ENOG4105E0F Histidine kinase GXW83_RS14840 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXW83_RS14845 ENOG4107W53 thymidine kinase GXW83_RS14860 ENOG4105C9B Cysteine desulfurase GXW83_RS14875 ENOG41073TP transcriptional regulator GXW83_RS14880 ENOG4105C7K acetolactate synthase GXW83_RS14885 ENOG4105CBC glutamate synthase GXW83_RS14930 ENOG4105WN5 stage II sporulation protein GXW83_RS14985 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GXW83_RS15000 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GXW83_RS15005 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GXW83_RS15010 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GXW83_RS15015 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GXW83_RS15035 ENOG4105D82 Glutamate dehydrogenase GXW83_RS15055 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GXW83_RS15065 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GXW83_RS15120 ENOG4105C57 major facilitator superfamily GXW83_RS15195 ENOG4108W6C Dehydrogenase GXW83_RS15200 ENOG4105CHR reductase GXW83_RS15280 ENOG4107TPY serine threonine protein kinase GXW83_RS15320 ENOG4107MM9 BNR Asp-box repeat-containing protein GXW83_RS15325 ENOG4108KXM LysR family Transcriptional regulator GXW83_RS15355 ENOG4105EKT )-iron permease GXW83_RS15370 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GXW83_RS15375 ENOG4105CEP NADH dehydrogenase GXW83_RS15380 ENOG4105C4M (Ubiquinol oxidase) subunit I GXW83_RS15430 ENOG4105CHR reductase GXW83_RS15435 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) GXW83_RS15440 ENOG4105EMU Dehydrogenase GXW83_RS15475 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS15480 ENOG4105BZU Histidine kinase GXW83_RS15495 ENOG4107TPY serine threonine protein kinase GXW83_RS15505 ENOG4108RQS Two component transcriptional regulator (Winged helix family GXW83_RS15665 ENOG4105D5G Transposase GXW83_RS15720 ENOG4105D5G Transposase GXW83_RS15745 ENOG4105D5G Transposase GXW83_RS15795 ENOG4105CPC Aldo Keto reductase GXW83_RS15875 ENOG4105ECQ AraC Family Transcriptional Regulator GXW83_RS15905 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GXW83_RS15925 ENOG4107RT4 flavin reductase domain protein GXW83_RS15930 ENOG4105EP9 oxidoreductase GXW83_RS15935 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GXW83_RS15940 ENOG4105CAY ferredoxin--nadp reductase GXW83_RS15945 ENOG4105C57 major facilitator superfamily GXW83_RS15955 ENOG4107XWB Zinc finger, swim domain protein GXW83_RS15960 ENOG4105C0D helicase GXW83_RS15970 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GXW83_RS16015 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GXW83_RS16020 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GXW83_RS16030 ENOG4105CVP deoxyribo-dipyrimidine photolyase GXW83_RS16060 ENOG4105HSS phospholipase C GXW83_RS16065 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) GXW83_RS16075 ENOG4105VBF alkaline shock protein GXW83_RS16085 ENOG41066YJ Beta-lactamase GXW83_RS16120 ENOG4108ZJI phenylacetic acid degradation protein GXW83_RS16125 ENOG4105CQ7 ATP-dependent helicase GXW83_RS16130 ENOG4105CHU acetyl-coa acetyltransferase GXW83_RS16135 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GXW83_RS16175 ENOG4105E98 transcriptional regulator DeoR family GXW83_RS16230 ENOG4105DEF Extracellular solute-binding protein, family 5 GXW83_RS16240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXW83_RS16255 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GXW83_RS16260 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GXW83_RS16305 ENOG4105BZU Histidine kinase GXW83_RS16325 ENOG4108J5G 6-phosphogluconate dehydrogenase GXW83_RS16335 ENOG4108WYP Transcriptional regulator GXW83_RS16370 ENOG4105CJA serine threonine protein kinase GXW83_RS16385 ENOG41067SE Tetr family transcriptional regulator GXW83_RS16435 ENOG4105CIH Imidazole acetol-phosphate transaminase GXW83_RS16440 ENOG4105X1Z Methyltransferase type 12 GXW83_RS16475 ENOG4105WQT MbtH domain protein GXW83_RS16490 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GXW83_RS16515 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXW83_RS16545 ENOG4105BZU Histidine kinase GXW83_RS16555 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GXW83_RS16560 ENOG4105FUA antagonist GXW83_RS16565 ENOG4107MMM Anti-sigma-factor antagonist GXW83_RS16590 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXW83_RS16610 ENOG4105BZU Histidine kinase GXW83_RS16630 ENOG4105C54 Major Facilitator superfamily GXW83_RS16635 ENOG4107WI4 Aldose-1-epimerase GXW83_RS16640 ENOG4105KF0 sporulation and cell division protein, SsgA GXW83_RS16645 ENOG4105WN5 stage II sporulation protein GXW83_RS16665 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXW83_RS16710 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) GXW83_RS16725 ENOG4105CGD Nad-dependent epimerase dehydratase GXW83_RS16755 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GXW83_RS16765 ENOG4105BZU Histidine kinase GXW83_RS16805 ENOG4105WN5 stage II sporulation protein GXW83_RS16810 ENOG41082AN stage II sporulation protein GXW83_RS16830 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GXW83_RS16870 ENOG4106F1P AAA ATPase, central domain protein GXW83_RS16890 ENOG4105EC2 ftsk spoIIIe GXW83_RS16900 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXW83_RS16905 ENOG4105DUX Transporter GXW83_RS16925 ENOG4105ES4 Nitrilase GXW83_RS16935 ENOG4105ERH Fumarylacetoacetate hydrolase GXW83_RS16940 ENOG4105RE0 Asp Glu hydantoin racemase GXW83_RS16955 ENOG4106KE4 Dehydrogenase GXW83_RS16970 ENOG4105EXC Acyl-transferase GXW83_RS16985 ENOG4105E1F short-chain dehydrogenase reductase GXW83_RS16990 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GXW83_RS17005 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GXW83_RS17015 ENOG4107QIM DNA ligase GXW83_RS17025 ENOG4105CSU acyl-Coa dehydrogenase GXW83_RS17050 ENOG4105C57 major facilitator superfamily GXW83_RS17080 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GXW83_RS17085 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS17090 ENOG4105BZU Histidine kinase GXW83_RS17125 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GXW83_RS17180 ENOG4108IG5 Transcriptional regulator GXW83_RS17185 ENOG4105CPC Aldo Keto reductase GXW83_RS17190 ENOG4105EDW glycosyl transferase, family 39 GXW83_RS17245 ENOG4105E8G Major facilitator Superfamily GXW83_RS17275 ENOG4105WN5 stage II sporulation protein GXW83_RS17285 ENOG4107R6F Alpha Beta Hydrolase Fold protein GXW83_RS17315 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GXW83_RS17380 ENOG4107QX8 SPFH domain, Band 7 family protein GXW83_RS17385 ENOG4107QRI Phosphoketolase GXW83_RS17390 ENOG4105D0M Protease HtpX homolog GXW83_RS17405 ENOG41067RQ csbd family GXW83_RS17425 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GXW83_RS17430 ENOG4105FUA antagonist GXW83_RS17435 ENOG4107MMM Anti-sigma-factor antagonist GXW83_RS17455 ENOG4105MWK D-amino acid dehydrogenase, small subunit GXW83_RS17495 ENOG4105BZU Histidine kinase GXW83_RS17595 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GXW83_RS17630 ENOG4105BZ4 penicillin-binding protein GXW83_RS17660 ENOG4107WN4 Polygalacturonase GXW83_RS17725 ENOG4107WN4 Polygalacturonase GXW83_RS17755 ENOG4105BZ4 penicillin-binding protein GXW83_RS17820 ENOG41064MX Tetr family transcriptional regulator GXW83_RS17850 ENOG4106NZI LysR family Transcriptional regulator GXW83_RS17895 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GXW83_RS17910 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GXW83_RS17915 ENOG4107S5I aldo keto reductase GXW83_RS17950 ENOG4108ZHR arsR family transcriptional regulator GXW83_RS17960 ENOG4105DRR Transcriptional regulator, GntR family GXW83_RS17975 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GXW83_RS18000 ENOG4107T6F Xaa-Pro aminopeptidase GXW83_RS18005 ENOG4105KXC Collagenase GXW83_RS18010 ENOG4108KXM LysR family Transcriptional regulator GXW83_RS18015 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS18025 ENOG4105E6M Sulphatase-modifying factor protein GXW83_RS18070 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS18075 ENOG4107Y80 Major Facilitator superfamily GXW83_RS18090 ENOG4105CPC Aldo Keto reductase GXW83_RS18120 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) GXW83_RS18125 ENOG4107B2H carbonic anhydrase GXW83_RS18130 ENOG4105DND Transcriptional regulator GXW83_RS18155 ENOG4108UMI ABC transporter, permease GXW83_RS18160 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GXW83_RS18165 ENOG4105D01 (LipO)protein GXW83_RS18180 ENOG4105BZU Histidine kinase GXW83_RS18220 ENOG4105CXN decarboxylase GXW83_RS18230 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) GXW83_RS18235 ENOG4105E2A Dehydrogenase GXW83_RS18250 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GXW83_RS18275 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) GXW83_RS18325 ENOG4105E2D ec 3.2.1.52 GXW83_RS18330 ENOG4105FDP GntR family transcriptional regulator GXW83_RS18365 ENOG4108M4U conserved membrane protein GXW83_RS18395 ENOG4105NAF rna polymerase sigma factor GXW83_RS18480 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GXW83_RS18495 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXW83_RS18555 ENOG4105DUX Transporter GXW83_RS18575 ENOG4107QM2 Aldo Keto reductase GXW83_RS18580 ENOG4108JPZ Monovalent cation H antiporter subunit D GXW83_RS18600 ENOG4105BZ1 (ABC) transporter GXW83_RS18610 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GXW83_RS18620 ENOG4105CQM Urea amidohydrolase subunit alpha GXW83_RS18625 ENOG4105KI2 Urea amidohydrolase subunit beta GXW83_RS18630 ENOG4108YZ9 Urea amidohydrolase subunit gamma GXW83_RS18655 ENOG4105CYP glycoside hydrolase, family GXW83_RS18660 ENOG4105DCG PHP domain protein GXW83_RS18670 ENOG4105FDF Could be involved in DNA repair (By similarity) GXW83_RS18710 ENOG4108428 Inherit from COG: -acetyltransferase GXW83_RS18740 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GXW83_RS18775 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GXW83_RS18785 ENOG4105F27 Major Facilitator GXW83_RS18790 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) GXW83_RS18815 ENOG4108HW4 amino acid AbC transporter GXW83_RS18850 ENOG4105F0K SARP family transcriptional regulator GXW83_RS18875 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GXW83_RS18915 ENOG4105D1K glutamate--cysteine ligase GXW83_RS18920 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process GXW83_RS18925 ENOG4108V75 Glutamine amidotransferase GXW83_RS18930 ENOG41067HS methyltransferase GXW83_RS18960 ENOG4107QX3 carboxylase GXW83_RS18975 ENOG4105KXX peptidase s58 dmpa GXW83_RS19030 ENOG4107Y3V -acetyltransferase GXW83_RS19060 ENOG4105CAY ferredoxin--nadp reductase GXW83_RS19105 ENOG4107R8N Glycosyl transferase, family 2 GXW83_RS19185 ENOG4105ECQ AraC Family Transcriptional Regulator GXW83_RS19195 ENOG4105C7K acetolactate synthase GXW83_RS19215 ENOG4105C31 Tryptophanyl-tRNA synthetase GXW83_RS19220 ENOG4105XPP Protein of unknown function (DUF1275) GXW83_RS19230 ENOG4108UZX fmn reductase GXW83_RS19235 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GXW83_RS19245 ENOG4107R5B glutamine synthetase GXW83_RS19255 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GXW83_RS19280 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GXW83_RS19285 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GXW83_RS19295 ENOG4108K8U Glycerol operon regulatory protein GXW83_RS19300 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GXW83_RS19305 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GXW83_RS19310 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GXW83_RS19320 ENOG4108TCJ secreted hydrolase GXW83_RS19350 ENOG4105E7W lamb ycsf family protein GXW83_RS19355 ENOG4105P4J Allophanate hydrolase, subunit 1 GXW83_RS19370 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase GXW83_RS19415 ENOG4105E39 Enoyl-CoA hydratase GXW83_RS19440 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GXW83_RS19460 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS19480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXW83_RS19485 ENOG4105C3U ABC transporter GXW83_RS19490 ENOG4108ZHJ Organic hydroperoxide resistance protein GXW83_RS19495 ENOG4105K56 Transcriptional regulator GXW83_RS19505 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GXW83_RS19515 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit GXW83_RS19520 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit GXW83_RS19525 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit GXW83_RS19530 ENOG4105MUA Resistance protein GXW83_RS19535 ENOG4105CSW GntR family transcriptional regulator GXW83_RS19560 ENOG410842T Pterin carbinolamine dehydratase GXW83_RS19570 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GXW83_RS19595 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS19600 ENOG4105BZU Histidine kinase GXW83_RS19645 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GXW83_RS19655 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS19660 ENOG4105C10 Electron transfer flavoprotein GXW83_RS19680 ENOG4105E9Q Acyl-transferase GXW83_RS19705 ENOG4105EYH Exonuclease GXW83_RS19710 ENOG4105CG3 alpha amylase, catalytic region GXW83_RS19715 ENOG4105BZM domain protein GXW83_RS19735 ENOG4107QP8 phosphohexose isomerase GXW83_RS19740 ENOG4105BZU Histidine kinase GXW83_RS19750 ENOG4105C1J atp-dependent rna helicase GXW83_RS19765 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS19770 ENOG4108MUZ hydrolase GXW83_RS19785 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GXW83_RS19800 ENOG4105DBE peroxidase GXW83_RS19810 ENOG4105FBN Acid phosphatase GXW83_RS19825 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS19835 ENOG4105CAQ asparagine synthetase GXW83_RS19840 ENOG4105CHP RNA polymerase GXW83_RS19845 ENOG4105GRZ Ycii-related protein GXW83_RS19860 ENOG4105Y3U Transglycosylase-associated protein GXW83_RS19885 ENOG4105CSR polyphosphate kinase 2 GXW83_RS19890 ENOG4105F8D glycoside hydrolase family 4 GXW83_RS19900 ENOG4105C3U ABC transporter GXW83_RS19935 ENOG4105CG3 alpha amylase, catalytic region GXW83_RS19980 ENOG4107YZX Universal stress protein GXW83_RS19985 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GXW83_RS20005 ENOG4105E5D amino acid GXW83_RS20075 ENOG4108UHU Aldolase GXW83_RS20100 ENOG4105CPQ Dehydrogenase GXW83_RS20105 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GXW83_RS20110 ENOG4106NZI LysR family Transcriptional regulator GXW83_RS20115 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GXW83_RS20120 ENOG4105NPE arsR family transcriptional regulator GXW83_RS20125 ENOG4105FDP GntR family transcriptional regulator GXW83_RS20130 ENOG4108QDA dioxygenase GXW83_RS20145 ENOG41080R8 Conserved Protein GXW83_RS20155 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GXW83_RS20170 ENOG41082SX arsR family transcriptional regulator GXW83_RS20175 ENOG4107TB5 TRANSCRIPTIONal GXW83_RS20205 ENOG4108S01 response regulator GXW83_RS20290 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXW83_RS20320 ENOG4107QYR Signal peptidase i GXW83_RS20325 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GXW83_RS20330 ENOG4105WN5 stage II sporulation protein GXW83_RS20340 ENOG4105EGE secreted protein GXW83_RS20350 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GXW83_RS20355 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GXW83_RS20360 ENOG4105C0X amino acid GXW83_RS20405 ENOG4105YVM Phosphoesterase, PA-phosphatase related GXW83_RS20480 ENOG4107YCR Transcriptional regulator, ARSR family GXW83_RS20490 ENOG41065HY 1,4-beta-cellobiosidase GXW83_RS20500 ENOG4107SGM protein serine threonine phosphatase GXW83_RS20510 ENOG4105CHR reductase GXW83_RS20565 ENOG4105VEQ Cold shock protein GXW83_RS20570 ENOG4105MS9 Resuscitation-promoting factor GXW83_RS20580 ENOG4105DIH basic membrane GXW83_RS20585 ENOG4108JQ9 ABC transporter GXW83_RS20590 ENOG4105UIB (ABC) transporter GXW83_RS20695 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GXW83_RS20705 ENOG4105EG6 Saccharopine dehydrogenase GXW83_RS20710 ENOG4105F4R Transcriptional regulator mode GXW83_RS20745 ENOG4105EX0 alpha-galactosidase GXW83_RS20760 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS20770 ENOG4105VEQ Cold shock protein GXW83_RS20785 ENOG4105C9U ATP-dependent DNA helicase RecQ GXW83_RS20805 ENOG4105EYF MMPL domain protein GXW83_RS20850 ENOG4108RZE Tetr family transcriptional regulator GXW83_RS20865 ENOG4105EA8 2-Nitropropane dioxygenase GXW83_RS20870 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GXW83_RS20880 ENOG4105CC9 acyl-Coa dehydrogenase GXW83_RS20885 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS20905 ENOG4105F2C Acetyl-CoA acetyltransferase GXW83_RS20950 ENOG4108IG5 Transcriptional regulator GXW83_RS20975 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GXW83_RS20980 ENOG4105CSU acyl-Coa dehydrogenase GXW83_RS20995 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GXW83_RS21000 ENOG4107QN2 dihydrolipoyl dehydrogenase GXW83_RS21015 ENOG4105DPX Hydrogenase, large subunit GXW83_RS21040 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GXW83_RS21100 ENOG4107JEE Short-chain dehydrogenase reductase Sdr GXW83_RS21105 ENOG4105BZP glycoside hydrolase 15-related GXW83_RS21130 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GXW83_RS21150 ENOG4105DQE DNA ligase GXW83_RS21175 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GXW83_RS21180 ENOG4105C26 Dehydrogenase GXW83_RS21185 ENOG4108Z86 Glutamine amidotransferase GXW83_RS21195 ENOG4105CUB amino acid GXW83_RS21205 ENOG41073TP transcriptional regulator GXW83_RS21225 ENOG4105EHG Permease protein GXW83_RS21230 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GXW83_RS21235 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GXW83_RS21280 ENOG4105D3Q Sugar transferase GXW83_RS21285 ENOG4105C30 Nad-dependent epimerase dehydratase GXW83_RS21290 ENOG4105C0K Gdp-mannose 4,6-dehydratase GXW83_RS21295 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF GXW83_RS21305 ENOG4106CD9 glycosyl transferase group 1 GXW83_RS21360 ENOG4105C0Z ABC transporter GXW83_RS21365 ENOG4108IV0 ABC, transporter GXW83_RS21405 ENOG4105BZU Histidine kinase GXW83_RS21445 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GXW83_RS21450 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GXW83_RS21475 ENOG4108JQ6 ABC transporter GXW83_RS21485 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXW83_RS21490 ENOG4105DEF Extracellular solute-binding protein, family 5 GXW83_RS21505 ENOG4105CIH Imidazole acetol-phosphate transaminase GXW83_RS21510 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GXW83_RS21540 ENOG4108IUW ABC transporter GXW83_RS21555 ENOG4105EQ0 Major Facilitator superfamily GXW83_RS21560 ENOG4108JGH Tetr family transcriptional regulator GXW83_RS21585 ENOG4105CIK Amidinotransferase GXW83_RS21600 ENOG4105C10 Electron transfer flavoprotein GXW83_RS21610 ENOG4105DD7 kinase (PfkB family GXW83_RS21615 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GXW83_RS21620 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GXW83_RS21635 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS21640 ENOG4108KDT Molybdate metabolism regulator GXW83_RS21660 ENOG4107T3P ABC, transporter GXW83_RS21670 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GXW83_RS21680 ENOG4105CG3 alpha amylase, catalytic region GXW83_RS21705 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GXW83_RS21730 ENOG4105CDH Citrulline--aspartate ligase GXW83_RS21760 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GXW83_RS21775 ENOG4105HSS phospholipase C GXW83_RS21785 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS21820 ENOG41080U6 GntR family transcriptional regulator GXW83_RS21850 ENOG4106F1P AAA ATPase, central domain protein GXW83_RS21855 ENOG4105EC2 ftsk spoIIIe GXW83_RS21915 ENOG4108HRK Histidine kinase GXW83_RS21920 ENOG4107QN1 sodium solute GXW83_RS21935 ENOG4108NEV two component transcriptional regulator, LytTR family GXW83_RS21940 ENOG4105K56 Transcriptional regulator GXW83_RS22005 ENOG4105WQT MbtH domain protein GXW83_RS22030 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS22035 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS22040 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS22110 ENOG410650H (LipO)protein GXW83_RS22115 ENOG4105DBE peroxidase GXW83_RS22125 ENOG4107EEY synthase GXW83_RS22130 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GXW83_RS22370 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS22425 ENOG4107RKG DJ-1/PfpI family GXW83_RS22430 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GXW83_RS22455 ENOG41061AU MarR family Transcriptional regulator GXW83_RS22465 ENOG4105BZU Histidine kinase GXW83_RS22470 ENOG41068KF Universal stress protein GXW83_RS22525 ENOG4105CM2 brancheD-chain amino acid aminotransferase GXW83_RS22530 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS22545 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXW83_RS22550 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GXW83_RS22555 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GXW83_RS22560 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GXW83_RS22580 ENOG4105E5G Alpha beta hydrolase fold GXW83_RS22600 ENOG4107SM8 Adenylate Guanylate cyclase GXW83_RS22625 ENOG4105CQF Transcriptional regulator GXW83_RS22640 ENOG4105CJA serine threonine protein kinase GXW83_RS22740 ENOG4106A3M Cytochrome p-450 GXW83_RS22750 ENOG4105F95 Monooxygenase GXW83_RS22760 ENOG4105DMF Dehydrogenase GXW83_RS22765 ENOG4107RSM transcriptional regulator GXW83_RS22780 ENOG4106R7G Glycoside hydrolase family 5 GXW83_RS22875 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS22895 ENOG4105C8Y Acetylornithine aminotransferase GXW83_RS22915 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXW83_RS22920 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GXW83_RS22975 ENOG4108S01 response regulator GXW83_RS22980 ENOG4108ZGX Histidine kinase GXW83_RS23030 ENOG4107RCI amp-dependent synthetase and ligase GXW83_RS23060 ENOG4107QSN dihydrolipoamide acetyltransferase GXW83_RS23075 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXW83_RS23080 ENOG4108JA1 polyketide synthase GXW83_RS23095 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS23135 ENOG41061H0 Monooxygenase GXW83_RS23145 ENOG4105CAQ asparagine synthetase GXW83_RS23165 ENOG4105CHR reductase GXW83_RS23175 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) GXW83_RS23180 ENOG41061H0 Monooxygenase GXW83_RS23185 ENOG4105CHR reductase GXW83_RS23190 ENOG41061H0 Monooxygenase GXW83_RS23215 ENOG4105CHR reductase GXW83_RS23240 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GXW83_RS23285 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GXW83_RS23300 ENOG4105CHR reductase GXW83_RS23400 ENOG4105DBV ornithine carbamoyltransferase GXW83_RS23405 ENOG4105CEU Arginine dihydrolase GXW83_RS23410 ENOG4105D5Q Arginine ornithine antiporter GXW83_RS23435 ENOG4108S93 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GXW83_RS23445 ENOG4105DYW oxidoreductase GXW83_RS23460 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS23495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXW83_RS23500 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXW83_RS23510 ENOG4105C5S asparaginyl-tRNA synthetase GXW83_RS23525 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GXW83_RS23540 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GXW83_RS23570 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS23575 ENOG4107RCI amp-dependent synthetase and ligase GXW83_RS23595 ENOG4107SET aldo keto reductase GXW83_RS23655 ENOG4105ED2 Beta-lactamase GXW83_RS23665 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GXW83_RS23680 ENOG4107SQU synthase GXW83_RS23685 ENOG4105E0T Short-chain dehydrogenase reductase Sdr GXW83_RS23695 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase GXW83_RS23700 ENOG41062T2 Acyl carrier protein GXW83_RS23705 ENOG4108KQ6 Enoyl-CoA hydratase GXW83_RS23710 ENOG4108MGH Enoyl-CoA hydratase GXW83_RS23715 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GXW83_RS23720 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GXW83_RS23725 ENOG4107QKG PfaD family GXW83_RS23730 ENOG4107SQU synthase GXW83_RS23740 ENOG4107SQU synthase GXW83_RS23745 ENOG4107SQU synthase GXW83_RS23750 ENOG4107SQU synthase GXW83_RS23755 ENOG4105C0W non-ribosomal peptide synthetase GXW83_RS23770 ENOG4106A3M Cytochrome p-450 GXW83_RS23775 ENOG4105E6M Sulphatase-modifying factor protein GXW83_RS23790 ENOG4105C3M thioredoxin reductase GXW83_RS23810 ENOG4105BZ1 (ABC) transporter GXW83_RS23815 ENOG4105BZ1 (ABC) transporter GXW83_RS23845 ENOG4105C5E polysaccharide biosynthesis protein GXW83_RS23870 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) GXW83_RS23895 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS23900 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXW83_RS23920 ENOG4105CHR reductase GXW83_RS23985 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS24005 ENOG4105C8Y Acetylornithine aminotransferase GXW83_RS24025 ENOG4108ZGX Histidine kinase GXW83_RS24030 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS24120 ENOG4105CIH Imidazole acetol-phosphate transaminase GXW83_RS24140 ENOG4105D1U peptidase U62 modulator of DNA gyrase GXW83_RS24175 ENOG4105D5G Transposase GXW83_RS24215 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GXW83_RS24245 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS24250 ENOG4105BZU Histidine kinase GXW83_RS24280 ENOG4105ECQ AraC Family Transcriptional Regulator GXW83_RS24285 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase GXW83_RS24335 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXW83_RS24350 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GXW83_RS24355 ENOG4105CFG Acts as a chaperone (By similarity) GXW83_RS24360 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GXW83_RS24375 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GXW83_RS24405 ENOG4106F59 XRE family Transcriptional regulator GXW83_RS24410 ENOG4105XUP Phage derived protein Gp49-like (DUF891) GXW83_RS24415 ENOG4105D5G Transposase GXW83_RS24460 ENOG4105VUF Transcriptional regulator GXW83_RS24480 ENOG4107WN4 Polygalacturonase GXW83_RS24655 ENOG41080R8 Conserved Protein GXW83_RS24660 ENOG4107QR9 Iron-sulfur cluster binding protein GXW83_RS24665 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GXW83_RS24670 ENOG4105DET Rhamnulokinase GXW83_RS24680 ENOG4105C9F isomerase GXW83_RS24685 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS24720 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS24800 ENOG4108W6C Dehydrogenase GXW83_RS24810 ENOG4107S5I aldo keto reductase GXW83_RS24875 ENOG4105E8G Major facilitator Superfamily GXW83_RS24880 ENOG4105C29 acyl-CoA thioesterase GXW83_RS24915 ENOG4105C0Z ABC transporter GXW83_RS24920 ENOG4108IV0 ABC, transporter GXW83_RS24925 ENOG4105MS9 Resuscitation-promoting factor GXW83_RS24940 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GXW83_RS24945 ENOG4105CAT Cytidine monophosphate kinase GXW83_RS24955 ENOG4105T38 integral membrane protein GXW83_RS24960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GXW83_RS24995 ENOG4105FE9 pseudouridine synthase GXW83_RS25000 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GXW83_RS25005 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GXW83_RS25020 ENOG4105DCF alanine dehydrogenase GXW83_RS25030 ENOG4108YZ4 nudix hydrolase GXW83_RS25035 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GXW83_RS25040 ENOG4105BZP glycoside hydrolase 15-related GXW83_RS25045 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GXW83_RS25055 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GXW83_RS25060 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GXW83_RS25085 ENOG4105DSU hydrolase GXW83_RS25125 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GXW83_RS25130 ENOG4108VX5 3-methyladenine DNA glycosylase GXW83_RS25135 ENOG4108V1U phospholipid-binding protein GXW83_RS25150 ENOG410842T Pterin carbinolamine dehydratase GXW83_RS25170 ENOG4105DKW ABC transporter GXW83_RS25180 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS25185 ENOG4105ENE Histidine kinase GXW83_RS25190 ENOG4105BZU Histidine kinase GXW83_RS25195 ENOG4105IDI abc transporter atp-binding protein GXW83_RS25205 ENOG4105EAC phosphoserine phosphatase GXW83_RS25215 ENOG4105DJ2 Major Facilitator Superfamily GXW83_RS25220 ENOG41073TP transcriptional regulator GXW83_RS25225 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GXW83_RS25260 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXW83_RS25270 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS25280 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GXW83_RS25290 ENOG4105BZP glycoside hydrolase 15-related GXW83_RS25315 ENOG4105VBF alkaline shock protein GXW83_RS25330 ENOG4105C5H ABC transporter GXW83_RS25360 ENOG4105E2K Glycosyl transferase (Group 1 GXW83_RS25370 ENOG4105CJR Integral membrane protein (MviN GXW83_RS25380 ENOG4105D3Q Sugar transferase GXW83_RS25400 ENOG4105PTV Nudix Hydrolase GXW83_RS25405 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GXW83_RS25425 ENOG4105CI0 Citrate lyase GXW83_RS25435 ENOG4105C1G acyl-Coa dehydrogenase GXW83_RS25440 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme GXW83_RS25475 ENOG4105C5F glutamine synthetase GXW83_RS25490 ENOG4105CJP fad dependent oxidoreductase GXW83_RS25500 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GXW83_RS25505 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GXW83_RS25510 ENOG4105CTK cobaltochelatase, cobn subunit GXW83_RS25525 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GXW83_RS25540 ENOG4105D3P Mannan endo-1,4-beta-mannosidase GXW83_RS25565 ENOG4106WTF Glycosyl transferase, family 2 GXW83_RS25580 ENOG4105CIA precorrin-4 C(11)-methyltransferase GXW83_RS25590 ENOG4105E4R Precorrin-3B C17-methyltransferase GXW83_RS25595 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GXW83_RS25610 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GXW83_RS25645 ENOG4105E9Z Nad-dependent epimerase dehydratase GXW83_RS25650 ENOG4106FN3 tellurium resistance protein GXW83_RS25660 ENOG4106178 UPF0339 protein GXW83_RS25715 ENOG4105C26 Dehydrogenase GXW83_RS25735 ENOG4105VG1 fes assembly suf system protein GXW83_RS25740 ENOG4108UNV SUF system FeS assembly protein, NifU family GXW83_RS25745 ENOG4105C9B Cysteine desulfurase GXW83_RS25750 ENOG4105C3K feS assembly ATPase SufC GXW83_RS25760 ENOG4105JRK feS assembly protein SufD GXW83_RS25785 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GXW83_RS25815 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GXW83_RS25820 ENOG4105CV1 Transketolase (EC 2.2.1.1) GXW83_RS25825 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GXW83_RS25840 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) GXW83_RS25855 ENOG4105CP7 Triose-phosphate isomerase GXW83_RS25860 ENOG4105BZA Phosphoglycerate kinase GXW83_RS25865 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GXW83_RS25880 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GXW83_RS25885 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GXW83_RS25900 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GXW83_RS25935 ENOG4105VEQ Cold shock protein GXW83_RS25950 ENOG4105VEQ Cold shock protein GXW83_RS25955 ENOG4105VEQ Cold shock protein GXW83_RS25960 ENOG4105C0R drug resistance transporter emrb qaca subfamily GXW83_RS25975 ENOG4105DU1 integral membrane protein, terc GXW83_RS25985 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GXW83_RS26005 ENOG4105DFU Cell wall formation (By similarity) GXW83_RS26010 ENOG4105E0X reductase GXW83_RS26030 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E GXW83_RS26050 ENOG4107JTW chlorite dismutase GXW83_RS26055 ENOG4105C1Q protoporphyrinogen oxidase GXW83_RS26065 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GXW83_RS26085 ENOG4105CHU acetyl-coa acetyltransferase GXW83_RS26095 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) GXW83_RS26115 ENOG4108HWW ABC transporter GXW83_RS26120 ENOG4105C2J ABC transporter GXW83_RS26125 ENOG4105DFW ABC transporter GXW83_RS26130 ENOG4105E2R ROK family GXW83_RS26150 ENOG4107QM5 aconitate hydratase GXW83_RS26155 ENOG4105DBV ornithine carbamoyltransferase GXW83_RS26210 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GXW83_RS26215 ENOG4105C0X amino acid GXW83_RS26220 ENOG4107VEG TrkA-N domain protein GXW83_RS26260 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GXW83_RS26290 ENOG4106F60 Histidine kinase GXW83_RS26295 ENOG4105F44 Two component transcriptional regulator, winged helix family GXW83_RS26310 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GXW83_RS26335 ENOG4105KHC sulfurtransferase GXW83_RS26350 ENOG4105CD5 CoA-binding domain protein GXW83_RS26355 ENOG410849S phosphocarrier protein (HPr) GXW83_RS26360 ENOG4105C26 Dehydrogenase GXW83_RS26365 ENOG41067RQ csbd family GXW83_RS26370 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GXW83_RS26380 ENOG410834F Transcriptional regulator GXW83_RS26410 ENOG4105D4P Coproporphyrinogen iii oxidase GXW83_RS26445 ENOG4105E0Y RtcB Protein GXW83_RS26470 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXW83_RS26490 ENOG4107QN1 sodium solute GXW83_RS26500 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS26505 ENOG4105BZU Histidine kinase GXW83_RS26515 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GXW83_RS26525 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GXW83_RS26530 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXW83_RS26545 ENOG4108JJB ABC transporter GXW83_RS26560 ENOG4105C9U ATP-dependent DNA helicase RecQ GXW83_RS26575 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GXW83_RS26585 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GXW83_RS26590 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GXW83_RS26595 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GXW83_RS26600 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GXW83_RS26605 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GXW83_RS26645 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GXW83_RS26650 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GXW83_RS26655 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GXW83_RS26665 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GXW83_RS26680 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GXW83_RS26725 ENOG4105KV4 Transcriptional regulator GXW83_RS26745 ENOG4105DWV Homoserine O-trans-acetylase GXW83_RS26750 ENOG4105EB3 Histidine kinase GXW83_RS26755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXW83_RS26760 ENOG4105CDA abc transporter atp-binding protein GXW83_RS26775 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GXW83_RS26780 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GXW83_RS26785 ENOG4105KC9 Modulates RecA activity (By similarity) GXW83_RS26805 ENOG4105C57 major facilitator superfamily GXW83_RS26830 ENOG4105WBV Transcriptional regulator GXW83_RS26835 ENOG4105CEV competence damage-inducible protein GXW83_RS26845 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GXW83_RS26855 ENOG4107QZI cell division protein FtsK GXW83_RS26860 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GXW83_RS26865 ENOG4105BZU Histidine kinase GXW83_RS26885 ENOG4105DKK Benzoate GXW83_RS26905 ENOG4105CN5 Metallo-Beta-Lactamase GXW83_RS26910 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GXW83_RS26915 ENOG4107V6K Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) GXW83_RS26930 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GXW83_RS26935 ENOG4105C1V Peptidase, M16 GXW83_RS26940 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GXW83_RS26945 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GXW83_RS26955 ENOG4105EC2 ftsk spoIIIe GXW83_RS27050 ENOG4107R4N Cell wall formation (By similarity) GXW83_RS27080 ENOG4108C33 Resolvase GXW83_RS27100 ENOG4105KAF membrAne GXW83_RS27115 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GXW83_RS27120 ENOG4105SFS phosphoesterase RecJ domain protein GXW83_RS27125 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GXW83_RS27150 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) GXW83_RS27165 ENOG4105BZU Histidine kinase GXW83_RS27180 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GXW83_RS27205 ENOG4105C26 Dehydrogenase GXW83_RS27220 ENOG4108JPW Aminotransferase GXW83_RS27250 ENOG4105C26 Dehydrogenase GXW83_RS27260 ENOG4105CJP fad dependent oxidoreductase GXW83_RS27275 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GXW83_RS27285 ENOG4105C26 Dehydrogenase GXW83_RS27295 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GXW83_RS27310 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GXW83_RS27315 ENOG4105KNE Phosphatidate cytidylyltransferase GXW83_RS27320 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GXW83_RS27325 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GXW83_RS27330 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GXW83_RS27335 ENOG4105CE9 30S ribosomal protein S2 GXW83_RS27350 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GXW83_RS27640 ENOG41080R2 UPF0102 protein GXW83_RS27650 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GXW83_RS27665 ENOG4107QYR Signal peptidase i GXW83_RS27675 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GXW83_RS27680 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GXW83_RS27685 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GXW83_RS27690 ENOG41082KU UPF0109 protein GXW83_RS27695 ENOG4105K5M 30s ribosomal protein S16 GXW83_RS27705 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) GXW83_RS27715 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GXW83_RS27720 ENOG4105D9U N-acetyltransferase GXW83_RS27730 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GXW83_RS27770 ENOG4108375 Acylphosphatase (EC 3.6.1.7) GXW83_RS27780 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GXW83_RS27785 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GXW83_RS27790 ENOG41084BZ 50S ribosomal protein L32 GXW83_RS27805 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GXW83_RS27810 ENOG4106H78 methyltransferase GXW83_RS27825 ENOG4105DP4 dak2 domain fusion protein ylov GXW83_RS27830 ENOG4105DWF phosphomethylpyrimidine kinase GXW83_RS27835 ENOG4105CTQ phosphohexokinase GXW83_RS27860 ENOG4105CPF Cell wall formation (By similarity) GXW83_RS27865 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GXW83_RS27885 ENOG4105K70 DNA-binding protein GXW83_RS27890 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GXW83_RS27895 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GXW83_RS27900 ENOG41069M3 Transcriptional regulator GXW83_RS27945 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GXW83_RS27960 ENOG4105GWZ Roadblock lc7 family protein GXW83_RS27980 ENOG4105GWZ Roadblock lc7 family protein GXW83_RS27995 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GXW83_RS28000 ENOG4105CM2 brancheD-chain amino acid aminotransferase GXW83_RS28005 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GXW83_RS28015 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GXW83_RS28050 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GXW83_RS28055 ENOG4108ZP8 Acetolactate synthase small subunit GXW83_RS28065 ENOG4105BZU Histidine kinase GXW83_RS28075 ENOG4107SM8 Adenylate Guanylate cyclase GXW83_RS28090 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GXW83_RS28100 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GXW83_RS28105 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GXW83_RS28110 ENOG4105BZU Histidine kinase GXW83_RS28115 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GXW83_RS28125 ENOG4105EMU Dehydrogenase GXW83_RS28140 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GXW83_RS28150 ENOG4107HP6 Transcriptional regulator GXW83_RS28155 ENOG4105EN6 Membrane GXW83_RS28160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXW83_RS28165 ENOG4108J59 Extracellular solute-binding protein, family 5 GXW83_RS28175 ENOG4105C3U ABC transporter GXW83_RS28180 ENOG4108JQ7 (ABC) transporter GXW83_RS28195 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GXW83_RS28200 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GXW83_RS28205 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GXW83_RS28210 ENOG4105EJQ L-serine dehydratase GXW83_RS28320 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GXW83_RS28365 ENOG4105CDU Replicative dna helicase GXW83_RS28510 ENOG4106A3M Cytochrome p-450 GXW83_RS28515 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GXW83_RS28520 ENOG4108IAJ Nad-dependent epimerase dehydratase GXW83_RS28555 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GXW83_RS28565 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GXW83_RS28595 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 GXW83_RS28620 ENOG4107TPY serine threonine protein kinase GXW83_RS28660 ENOG4108JPW Aminotransferase GXW83_RS28670 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GXW83_RS28675 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GXW83_RS28680 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GXW83_RS28685 ENOG4105EUJ GTP cyclohydrolase i GXW83_RS28695 ENOG4105ERH Fumarylacetoacetate hydrolase GXW83_RS28700 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GXW83_RS28705 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) GXW83_RS28710 ENOG4108JPW Aminotransferase GXW83_RS28715 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) GXW83_RS28725 ENOG4105DJI Methylaspartate mutase, E subunit GXW83_RS28750 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GXW83_RS28800 ENOG4108AEY RNA polymerase sigma factor GXW83_RS28815 ENOG4105BZ1 (ABC) transporter GXW83_RS28820 ENOG4105BZ1 (ABC) transporter GXW83_RS28845 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GXW83_RS28850 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) GXW83_RS28860 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) GXW83_RS28865 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GXW83_RS28890 ENOG4105C6K Malic enzyme GXW83_RS28895 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GXW83_RS28965 ENOG4105CHU acetyl-coa acetyltransferase GXW83_RS28985 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GXW83_RS29015 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) GXW83_RS29030 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GXW83_RS29040 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GXW83_RS29055 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GXW83_RS29060 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GXW83_RS29065 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GXW83_RS29070 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GXW83_RS29075 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GXW83_RS29080 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GXW83_RS29085 ENOG4105ZA1 atp synthase GXW83_RS29095 ENOG4105Z3P ATP synthase GXW83_RS29100 ENOG4105ESV Glycosyl transferase, family 4 GXW83_RS29110 ENOG4107ZF2 Phosphatase GXW83_RS29120 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GXW83_RS29125 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GXW83_RS29130 ENOG4105VFB Binds the 23S rRNA (By similarity) GXW83_RS29145 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GXW83_RS29150 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GXW83_RS29160 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GXW83_RS29165 ENOG4105C75 arginyL-tRNA synthetase GXW83_RS29170 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GXW83_RS29230 ENOG4105D9U N-acetyltransferase GXW83_RS29275 ENOG4105CMG Carbohydrate kinase GXW83_RS29305 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GXW83_RS29310 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GXW83_RS29320 ENOG4108PYU two-component system response regulator GXW83_RS29325 ENOG4105EB3 Histidine kinase GXW83_RS29330 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GXW83_RS29355 ENOG4105CB2 alcohol dehydrogenase GXW83_RS29360 ENOG4105C6K Malic enzyme GXW83_RS29375 ENOG4108VEQ Superoxide dismutase GXW83_RS29410 ENOG4105CBD Diacylglycerol kinase GXW83_RS29435 ENOG4105D17 glycoside hydrolase, family 3 domain protein GXW83_RS29455 ENOG4105FDP GntR family transcriptional regulator GXW83_RS29475 ENOG4105C26 Dehydrogenase GXW83_RS29480 ENOG4105C26 Dehydrogenase GXW83_RS29490 ENOG4108KXV response regulator GXW83_RS29495 ENOG41065SU Two-component system sensor kinase GXW83_RS29520 ENOG4107RSM transcriptional regulator GXW83_RS29525 ENOG4105D94 Major Facilitator Superfamily GXW83_RS29540 ENOG4107RM1 amidohydrolase GXW83_RS29580 ENOG4105DZ1 carboxypeptidase GXW83_RS29600 ENOG4105ETX regulatoR GXW83_RS29610 ENOG4107SJB teichoic acid biosynthesis GXW83_RS29620 ENOG4107SJB teichoic acid biosynthesis GXW83_RS29635 ENOG4105C31 Tryptophanyl-tRNA synthetase GXW83_RS29645 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GXW83_RS29650 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GXW83_RS29670 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GXW83_RS29680 ENOG4105W8D rdd domain containing protein GXW83_RS29685 ENOG4105DC1 bifunctional purine biosynthesis protein purh GXW83_RS29715 ENOG4105CMV Succinyl-CoA synthetase subunit beta GXW83_RS29725 ENOG4105DEG Vwa containing coxe family protein GXW83_RS29735 ENOG4105KKX ATPase associated with various cellular activities aaa_5 GXW83_RS29765 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) GXW83_RS29770 ENOG4105K4H Nlp p60 protein GXW83_RS29775 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS29805 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GXW83_RS29820 ENOG4105C26 Dehydrogenase GXW83_RS29850 ENOG4105C6Y Udp-glucose 6-dehydrogenase GXW83_RS29860 ENOG4107QN2 dihydrolipoyl dehydrogenase GXW83_RS29865 ENOG4105D9P serine threonine protein kinase GXW83_RS29875 ENOG4105D9P serine threonine protein kinase GXW83_RS29880 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GXW83_RS29890 ENOG4107QVP Dehydrogenase GXW83_RS29900 ENOG4108MMM RNA Polymerase GXW83_RS29905 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS29910 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) GXW83_RS29915 ENOG4105DND Transcriptional regulator GXW83_RS29930 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GXW83_RS29945 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GXW83_RS29970 ENOG4108097 ATP-binding protein GXW83_RS29980 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GXW83_RS29990 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GXW83_RS30010 ENOG4105CS9 pantothenic acid kinase GXW83_RS30020 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GXW83_RS30025 ENOG4108UJD 30S ribosomal protein S9 GXW83_RS30030 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GXW83_RS30035 ENOG4105C5H ABC transporter GXW83_RS30045 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GXW83_RS30050 ENOG4108ZT0 50S ribosomal protein l17 GXW83_RS30055 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GXW83_RS30060 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GXW83_RS30065 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GXW83_RS30070 ENOG41067V7 50S ribosomal protein L36 GXW83_RS30075 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GXW83_RS30085 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GXW83_RS30090 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GXW83_RS30095 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GXW83_RS30105 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GXW83_RS30110 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GXW83_RS30115 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GXW83_RS30120 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GXW83_RS30125 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GXW83_RS30130 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GXW83_RS30135 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GXW83_RS30140 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GXW83_RS30145 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GXW83_RS30150 ENOG41082SA 50s ribosomal protein l29 GXW83_RS30155 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GXW83_RS30160 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GXW83_RS30165 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GXW83_RS30170 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GXW83_RS30175 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GXW83_RS30185 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GXW83_RS30190 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GXW83_RS30195 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GXW83_RS30220 ENOG4107QJZ Glycosyl transferase, family 2 GXW83_RS30230 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GXW83_RS30255 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GXW83_RS30260 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GXW83_RS30265 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GXW83_RS30285 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GXW83_RS30290 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GXW83_RS30300 ENOG4108VZM 50s ribosomal protein L10 GXW83_RS30310 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GXW83_RS30315 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GXW83_RS30320 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GXW83_RS30345 ENOG4107R4N Cell wall formation (By similarity) GXW83_RS30365 ENOG410900P UPF0336 protein GXW83_RS30370 ENOG4105WDJ 50S ribosomal protein L33 GXW83_RS30410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GXW83_RS30425 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GXW83_RS30430 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea GXW83_RS30460 ENOG4105VB9 50S ribosomal protein l28 GXW83_RS30470 ENOG4108VPT UPF0234 protein GXW83_RS30475 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GXW83_RS30495 ENOG4105D0M Protease HtpX homolog GXW83_RS30500 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS30505 ENOG4105C8S subunit m GXW83_RS30510 ENOG4105D65 subunit l GXW83_RS30515 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS30520 ENOG4107YX3 NADH dehydrogenase subunit j GXW83_RS30525 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS30535 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GXW83_RS30540 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS30570 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GXW83_RS30580 ENOG4105C0H protease GXW83_RS30630 ENOG4105BZU Histidine kinase GXW83_RS30635 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GXW83_RS30640 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GXW83_RS30645 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GXW83_RS30650 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GXW83_RS30655 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GXW83_RS30685 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) GXW83_RS30690 ENOG4108ZT1 Transcriptional regulator GXW83_RS30700 ENOG4105CRK lysyL-tRNA synthetase GXW83_RS30710 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS30720 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GXW83_RS30750 ENOG4105CSH Transporter GXW83_RS30770 ENOG4105C5H ABC transporter GXW83_RS30775 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GXW83_RS30780 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GXW83_RS30790 ENOG4105F8V Hydrolase, tatD family GXW83_RS30795 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GXW83_RS30815 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GXW83_RS30825 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS30830 ENOG4108ZGX Histidine kinase GXW83_RS30835 ENOG4108RVA ribokinase GXW83_RS30845 ENOG4107QHZ cell cycle protein GXW83_RS30860 ENOG4105ETX regulatoR GXW83_RS30915 ENOG4105D9U N-acetyltransferase GXW83_RS30920 ENOG4108RIR Molybdenum cofactor biosynthesis protein GXW83_RS30925 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GXW83_RS30935 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GXW83_RS30945 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase GXW83_RS30975 ENOG4105EDW glycosyl transferase, family 39 GXW83_RS30985 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS31010 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GXW83_RS31015 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GXW83_RS31025 ENOG4108KC2 acyl-Coa dehydrogenase GXW83_RS31035 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GXW83_RS31060 ENOG4105CMV Succinyl-CoA synthetase subunit beta GXW83_RS31065 ENOG4105CGU Enoyl-CoA hydratase GXW83_RS31075 ENOG4105MXW flavin reductase domain protein, FMN-binding GXW83_RS31105 ENOG4105C7N Xanthine uracil vitamin C permease GXW83_RS31115 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GXW83_RS31135 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GXW83_RS31155 ENOG4105CRE cytochrome C GXW83_RS31160 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) GXW83_RS31165 ENOG4107QIV Cytochrome c biogenesis protein GXW83_RS31170 ENOG4107ZT5 Thiol disulfide interchange protein GXW83_RS31175 ENOG4108RH7 phosphoglycerate mutase GXW83_RS31180 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GXW83_RS31300 ENOG4105D52 delta-aminolevulinic acid dehydratase GXW83_RS31305 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GXW83_RS31310 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GXW83_RS31315 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GXW83_RS31360 ENOG4105DGU Histone deacetylase GXW83_RS31375 ENOG4107YBY Hydrolase GXW83_RS31380 ENOG4105II7 pyrroline-5-carboxylate reductase GXW83_RS31395 ENOG4105C01 Dihydroxy-acid dehydratase GXW83_RS31400 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GXW83_RS31405 ENOG4105EY0 Xylose isomerase domain protein TIM barrel GXW83_RS31410 ENOG4107R33 ppx gppa phosphatase GXW83_RS31425 ENOG4108JWX GXW83_RS31440 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GXW83_RS31455 ENOG4107XI7 Tetr family transcriptional regulator GXW83_RS31460 ENOG4105C26 Dehydrogenase GXW83_RS31510 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GXW83_RS31515 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GXW83_RS31520 ENOG4108IYU L-aspartate oxidase GXW83_RS31525 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GXW83_RS31530 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GXW83_RS31535 ENOG4105CEY Amp-dependent synthetase and ligase GXW83_RS31545 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS31550 ENOG4105BZU Histidine kinase GXW83_RS31560 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GXW83_RS31570 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GXW83_RS31580 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GXW83_RS31605 ENOG41066UM arsR family transcriptional regulator GXW83_RS31635 ENOG4105PMW Domain of unknown function (DUF1990) GXW83_RS31640 ENOG4105WH1 Two component transcriptional regulator luxr family GXW83_RS31655 ENOG4107TB5 TRANSCRIPTIONal GXW83_RS31670 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GXW83_RS31715 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GXW83_RS31725 ENOG4105C2N RNA methyltransferase TrmH family group 3 GXW83_RS31730 ENOG4105C8N cysteinyl-tRNA synthetase GXW83_RS31735 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GXW83_RS31740 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GXW83_RS31745 ENOG4108VJ1 Transcriptional regulator (CarD family GXW83_RS31755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GXW83_RS31760 ENOG4105BZU Histidine kinase GXW83_RS31775 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GXW83_RS31785 ENOG4105HHS UPF0256 protein GXW83_RS31790 ENOG41067SE Tetr family transcriptional regulator GXW83_RS31815 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GXW83_RS31820 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GXW83_RS31825 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase GXW83_RS31890 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GXW83_RS31910 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GXW83_RS31915 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GXW83_RS31925 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands GXW83_RS31935 ENOG4105PKJ carbohydrate binding GXW83_RS31940 ENOG4105KHC sulfurtransferase GXW83_RS31965 ENOG4107NHD transcriptional regulator GXW83_RS31970 ENOG4105ETE Transcriptional regulator (LacI family GXW83_RS31975 ENOG4105C0H protease GXW83_RS31995 ENOG4105XUP Phage derived protein Gp49-like (DUF891) GXW83_RS32000 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GXW83_RS32005 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GXW83_RS32020 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GXW83_RS32035 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GXW83_RS32040 ENOG4105CJ3 phosphate transporter GXW83_RS32050 ENOG4105VPX protein, conserved in bacteria GXW83_RS32070 ENOG4105DNP FAD linked oxidase domain protein GXW83_RS32075 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GXW83_RS32080 ENOG4105K4H Nlp p60 protein GXW83_RS32185 ENOG4105D5U fad dependent oxidoreductase GXW83_RS32190 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GXW83_RS32220 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GXW83_RS32225 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GXW83_RS32245 ENOG4105BZU Histidine kinase GXW83_RS32250 ENOG4105GWZ Roadblock lc7 family protein GXW83_RS32265 ENOG4105E90 ABC transporter GXW83_RS32270 ENOG4105E90 ABC transporter GXW83_RS32275 ENOG4108IJ8 ABC transporter GXW83_RS32280 ENOG4107TB5 TRANSCRIPTIONal GXW83_RS32305 ENOG4105RNG membrane GXW83_RS32310 ENOG4105K6V RNA polymerase GXW83_RS32425 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GXW83_RS32435 ENOG4105C1J atp-dependent rna helicase GXW83_RS32480 ENOG4108222 arsenate reductase GXW83_RS32490 ENOG4107ZR7 Membrane GXW83_RS32515 ENOG410630P Transcriptional regulator GXW83_RS32520 ENOG41083YR Protein CrcB homolog GXW83_RS32525 ENOG41083TI Protein CrcB homolog GXW83_RS32560 ENOG4105CXB phosphoribosylaminoimidazole synthetase GXW83_RS32585 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GXW83_RS32590 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GXW83_RS32595 ENOG410839H phosphoribosylformylglycinamidine synthase GXW83_RS32615 ENOG4105C8V SAICAR synthetase GXW83_RS32630 ENOG4105C12 Phosphoribosylglycinamide synthetase GXW83_RS32645 ENOG4105DRR Transcriptional regulator, GntR family GXW83_RS32665 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GXW83_RS32680 ENOG4107RCW fructose-bisphosphate aldolase GXW83_RS32685 ENOG4105DQR SNARE associated Golgi GXW83_RS32690 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GXW83_RS32705 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GXW83_RS32725 ENOG4105DIK (ABC) transporter GXW83_RS32755 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A GXW83_RS32775 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GXW83_RS32790 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GXW83_RS32825 ENOG4105DFM M18 family aminopeptidase GXW83_RS32830 ENOG4105CSU acyl-Coa dehydrogenase GXW83_RS32840 ENOG4105EUB pirin domain protein GXW83_RS32865 ENOG4108RK3 acyl-Coa dehydrogenase GXW83_RS32880 ENOG4105CVM Molybdenum cofactor synthesis domain protein GXW83_RS32895 ENOG4108KGH TRANSCRIPTIONal GXW83_RS32905 ENOG4105ECY inositol monophosphatase GXW83_RS32930 ENOG4105NAF rna polymerase sigma factor GXW83_RS32960 ENOG4107QPV Serine Threonine protein kinase GXW83_RS32980 ENOG4105CPP Dehydrogenase, E1 component GXW83_RS32985 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 GXW83_RS33015 ENOG4108UTZ Dihydroxyacetone kinase GXW83_RS33020 ENOG4105CMT Dihydroxyacetone kinase GXW83_RS33025 ENOG4105VDH Dihydroxyacetone kinase GXW83_RS33040 ENOG4105KNI merR family transcriptional Regulator GXW83_RS33045 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GXW83_RS33050 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GXW83_RS33055 ENOG4105CFG Acts as a chaperone (By similarity) GXW83_RS33060 ENOG4105DF6 Fe-S oxidoreductase GXW83_RS33075 ENOG4105DHP deoxycytidine triphosphate deaminase GXW83_RS33160 ENOG4105CFF transcriptional regulator GXW83_RS33180 ENOG41065RQ ADP-ribosylation crystallin J1 GXW83_RS33205 ENOG4105CZE histidine utilization repressor GXW83_RS33245 ENOG4105D29 Helix-turn-helix type 11 domain protein GXW83_RS33260 ENOG4107SCK Monooxygenase GXW83_RS33270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GXW83_RS33275 ENOG4105D5G Transposase GXW83_RS33285 ENOG4105VEQ Cold shock protein GXW83_RS33310 ENOG4105D3W isochorismatase GXW83_RS33320 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GXW83_RS33335 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GXW83_RS33340 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GXW83_RS33370 ENOG4105FF5 Membrane GXW83_RS33400 ENOG4105EYW Ion transport protein GXW83_RS33425 ENOG4107SCK Monooxygenase GXW83_RS33450 ENOG4105CDU Replicative dna helicase GXW83_RS33455 ENOG4107QI1 Mate efflux family protein GXW83_RS33465 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GXW83_RS33470 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GXW83_RS33475 ENOG4107YH6 single-stranded DNA-binding protein GXW83_RS33480 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) GXW83_RS33505 ENOG4105BZ4 penicillin-binding protein GXW83_RS33515 ENOG4105CZA synthase GXW83_RS33525 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GXW83_RS33540 ENOG4105D9P serine threonine protein kinase GXW83_RS33555 ENOG4105C3M thioredoxin reductase GXW83_RS33560 ENOG4105K63 Thioredoxin GXW83_RS33565 ENOG4108E1C hydrolase GXW83_RS33585 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GXW83_RS33595 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GXW83_RS33600 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GXW83_RS33610 ENOG41084CH 50S ribosomal protein l34