locus-tag	class	description
GXW83_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GXW83_RS00010	COG0592	DNA-directed DNA polymerase activity
GXW83_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GXW83_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GXW83_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GXW83_RS00030	COG0187	DNA topoisomerase II activity
GXW83_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GXW83_RS00090	COG3764	Sortase (surface protein transpeptidase)
GXW83_RS00095	COG3764	Sortase (surface protein transpeptidase)
GXW83_RS00105	COG0515	serine threonine protein kinase
GXW83_RS00125	COG1716	ATPase activity
GXW83_RS00130	COG1716	ATPase activity
GXW83_RS00130	COG1716	ATPase activity
GXW83_RS00145	COG1942	4-Oxalocrotonate Tautomerase
GXW83_RS00150	COG2409	Drug exporters of the RND superfamily
GXW83_RS00160	COG2208	phosphoserine phosphatase activity
GXW83_RS00170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GXW83_RS00175	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS00200	COG1522	sequence-specific DNA binding
GXW83_RS00205	COG1309	transcriptional regulator
GXW83_RS00210	COG0477	Major facilitator Superfamily
GXW83_RS00225	COG0531	amino acid
GXW83_RS00235	COG3842	ATPase activity
GXW83_RS00240	COG1176	ABC-type spermidine putrescine transport system, permease component I
GXW83_RS00245	COG1177	transmembrane transport
GXW83_RS00255	COG3617	BRO family, N-terminal domain
GXW83_RS00260	COG2814	Major facilitator Superfamily
GXW83_RS00265	COG1902	pentaerythritol trinitrate reductase activity
GXW83_RS00295	COG1950	PFAM Membrane protein of
GXW83_RS00300	COG0662	Cupin 2, conserved barrel domain protein
GXW83_RS00305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GXW83_RS00315	COG2268	Band 7 protein
GXW83_RS00325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GXW83_RS00365	COG1609	Transcriptional regulator
GXW83_RS00370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GXW83_RS00380	COG1136	(ABC) transporter
GXW83_RS00380	COG0577	efflux transmembrane transporter activity
GXW83_RS00395	COG1136	(ABC) transporter
GXW83_RS00395	COG4591	ABC-type transport system involved in lipoprotein release permease component
GXW83_RS00415	COG2205	protein histidine kinase activity
GXW83_RS00425	COG1294	oxidase, subunit
GXW83_RS00430	COG4988	ABC transporter
GXW83_RS00435	COG0561	phosphatase activity
GXW83_RS00485	COG1131	(ABC) transporter
GXW83_RS00495	COG1131	(ABC) transporter
GXW83_RS00505	COG2807	transmembrane transport
GXW83_RS00510	COG2186	Transcriptional regulator
GXW83_RS00520	COG0561	phosphatase activity
GXW83_RS00525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GXW83_RS00535	COG2837	iron assimilation
GXW83_RS00550	COG1999	signal sequence binding
GXW83_RS00570	COG0789	Transcriptional regulator
GXW83_RS00575	COG0006	proline dipeptidase activity
GXW83_RS00595	COG0653	protein targeting
GXW83_RS00680	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS00685	COG0745	RESPONSE REGULATOR receiver
GXW83_RS00710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GXW83_RS00720	COG0640	Transcriptional regulator
GXW83_RS00765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXW83_RS00770	COG4948	Mandelate Racemase Muconate Lactonizing
GXW83_RS00780	COG2365	Tyrosine phosphatase family
GXW83_RS00785	COG1191	sigma factor activity
GXW83_RS00805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GXW83_RS00830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GXW83_RS00870	COG1940	carbohydrate kinase activity
GXW83_RS00890	COG1215	transferase activity, transferring glycosyl groups
GXW83_RS00905	COG2268	Band 7 protein
GXW83_RS00925	COG1472	Belongs to the glycosyl hydrolase 3 family
GXW83_RS00950	COG1408	metallophosphoesterase
GXW83_RS01035	COG0714	Associated with various cellular activities
GXW83_RS01050	COG4115	mRNA cleavage
GXW83_RS01055	COG2161	toxin-antitoxin pair type II binding
GXW83_RS01130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GXW83_RS01140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GXW83_RS01230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GXW83_RS01235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GXW83_RS01250	COG1595	DNA-templated transcription, initiation
GXW83_RS01275	COG2814	Major facilitator Superfamily
GXW83_RS01280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GXW83_RS01330	COG3629	intracellular signal transduction
GXW83_RS01330	COG3903	Transcriptional regulator
GXW83_RS01340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GXW83_RS01365	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS01395	COG2226	methyltransferase
GXW83_RS01400	COG0187	DNA topoisomerase II activity
GXW83_RS01405	COG0187	DNA topoisomerase II activity
GXW83_RS01425	COG1408	metallophosphoesterase
GXW83_RS01435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXW83_RS01445	COG0003	Pfam Anion-transporting ATPase
GXW83_RS01470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXW83_RS01495	COG2267	carboxylic ester hydrolase activity
GXW83_RS01505	COG0589	response to stress
GXW83_RS01590	COG2267	carboxylic ester hydrolase activity
GXW83_RS01605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXW83_RS01665	COG1205	dead DEAH box helicase
GXW83_RS01665	COG1111	helicase
GXW83_RS01670	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS01675	COG2172	sigma factor antagonist activity
GXW83_RS01680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GXW83_RS01690	COG2890	protein-(glutamine-N5) methyltransferase activity
GXW83_RS01700	COG1754	DNA topoisomerase type I activity
GXW83_RS01700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GXW83_RS01705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GXW83_RS01710	COG0470	DNA polymerase III
GXW83_RS01780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GXW83_RS01805	COG2814	Major facilitator Superfamily
GXW83_RS01810	COG1846	Transcriptional regulator
GXW83_RS01815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GXW83_RS01875	COG0671	phosphoesterase, PA-phosphatase related
GXW83_RS01880	COG0586	Pfam SNARE associated Golgi protein
GXW83_RS01885	COG0586	Pfam SNARE associated Golgi protein
GXW83_RS01905	COG0745	RESPONSE REGULATOR receiver
GXW83_RS01910	COG2205	protein histidine kinase activity
GXW83_RS01930	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GXW83_RS02150	COG1215	transferase activity, transferring glycosyl groups
GXW83_RS02165	COG0438	transferase activity, transferring glycosyl groups
GXW83_RS02255	COG0640	Transcriptional regulator
GXW83_RS02280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GXW83_RS02380	COG0038	chloride channel
GXW83_RS02395	COG2801	Transposase and inactivated derivatives
GXW83_RS02420	COG2181	nitrate reductase activity
GXW83_RS02420	COG0247	lactate metabolic process
GXW83_RS02445	COG2837	iron assimilation
GXW83_RS02455	COG0076	glutamate decarboxylase activity
GXW83_RS02455	COG0076	glutamate decarboxylase activity
GXW83_RS02460	COG0038	chloride channel
GXW83_RS02505	COG0531	amino acid
GXW83_RS02560	COG0305	Participates in initiation and elongation during chromosome replication
GXW83_RS02705	COG2223	nitrite transmembrane transporter activity
GXW83_RS02715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GXW83_RS02715	COG2146	nitrite reductase [NAD(P)H] activity
GXW83_RS02720	COG0745	RESPONSE REGULATOR receiver
GXW83_RS02725	COG0243	molybdopterin cofactor binding
GXW83_RS02735	COG3189	MarR family transcriptional regulator
GXW83_RS02750	COG1846	Transcriptional regulator
GXW83_RS02755	COG4974	Belongs to the 'phage' integrase family
GXW83_RS02790	COG0494	nUDIX hydrolase
GXW83_RS02835	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GXW83_RS02845	COG3328	transposase activity
GXW83_RS02865	COG0582	viral genome integration into host DNA
GXW83_RS02960	COG3547	Transposase (IS116 IS110 IS902 family)
GXW83_RS02975	COG3547	Transposase (IS116 IS110 IS902 family)
GXW83_RS03005	COG1316	TRANSCRIPTIONal
GXW83_RS03015	COG2124	cytochrome p450
GXW83_RS03025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GXW83_RS03060	COG3883	PFAM NLP P60 protein
GXW83_RS03060	COG0791	NLP P60 protein
GXW83_RS03065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GXW83_RS03070	COG2027	D-alanyl-D-alanine carboxypeptidase
GXW83_RS03080	COG0037	tRNA processing
GXW83_RS03095	COG0302	gtp cyclohydrolase
GXW83_RS03110	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GXW83_RS03110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GXW83_RS03115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GXW83_RS03125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GXW83_RS03150	COG3483	tryptophan 2,3-dioxygenase activity
GXW83_RS03155	COG1522	sequence-specific DNA binding
GXW83_RS03165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GXW83_RS03175	COG2318	DinB family
GXW83_RS03190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GXW83_RS03200	COG3300	MHYT domain
GXW83_RS03200	COG5001	Diguanylate cyclase
GXW83_RS03210	COG1228	amidohydrolase
GXW83_RS03230	COG0395	ABC-type sugar transport system, permease component
GXW83_RS03260	COG0463	Glycosyl transferase, family 2
GXW83_RS03305	COG3973	AAA domain
GXW83_RS03320	COG1061	Type III restriction enzyme res subunit
GXW83_RS03335	COG0789	Transcriptional regulator
GXW83_RS03380	COG1278	Cold shock
GXW83_RS03385	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GXW83_RS03390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GXW83_RS03400	COG2814	Major facilitator Superfamily
GXW83_RS03425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GXW83_RS03430	COG0109	protoheme IX farnesyltransferase activity
GXW83_RS03435	COG2197	response regulator
GXW83_RS03440	COG4585	Histidine kinase
GXW83_RS03455	COG0163	prenyltransferase activity
GXW83_RS03460	COG1522	sequence-specific DNA binding
GXW83_RS03465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GXW83_RS03470	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GXW83_RS03485	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GXW83_RS03495	COG0259	pyridoxamine-phosphate oxidase activity
GXW83_RS03505	COG0641	radical SAM
GXW83_RS03520	COG3903	Transcriptional regulator
GXW83_RS03520	COG3629	intracellular signal transduction
GXW83_RS03540	COG4821	SIS domain
GXW83_RS03580	COG1595	DNA-templated transcription, initiation
GXW83_RS03590	COG1216	Glycosyl transferase, family 2
GXW83_RS03595	COG3507	Belongs to the glycosyl hydrolase 43 family
GXW83_RS03595	COG3693	PFAM glycoside hydrolase, family 10
GXW83_RS03595	COG2382	esterase
GXW83_RS03600	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS03615	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS03635	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS03640	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS03690	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GXW83_RS03695	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GXW83_RS03705	COG2226	methyltransferase
GXW83_RS03725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXW83_RS03730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXW83_RS03735	COG0649	NAD binding
GXW83_RS03745	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GXW83_RS03750	COG1034	ATP synthesis coupled electron transport
GXW83_RS03755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GXW83_RS03760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXW83_RS03770	COG0713	ATP synthesis coupled electron transport
GXW83_RS03775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GXW83_RS03785	COG1007	ATP synthesis coupled electron transport
GXW83_RS03800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GXW83_RS03800	COG0674	pyruvate-flavodoxin oxidoreductase activity
GXW83_RS03805	COG1013	pyruvate-flavodoxin oxidoreductase activity
GXW83_RS03810	COG0531	amino acid
GXW83_RS03845	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GXW83_RS03850	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS03875	COG1686	Belongs to the peptidase S11 family
GXW83_RS03900	COG2197	response regulator
GXW83_RS03905	COG4585	Histidine kinase
GXW83_RS03995	COG0596	Alpha beta hydrolase
GXW83_RS04035	COG3903	Transcriptional regulator
GXW83_RS04035	COG3629	intracellular signal transduction
GXW83_RS04045	COG0783	Belongs to the Dps family
GXW83_RS04050	COG4977	sequence-specific DNA binding
GXW83_RS04055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GXW83_RS04070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXW83_RS04100	COG1595	DNA-templated transcription, initiation
GXW83_RS04130	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS04140	COG2017	converts alpha-aldose to the beta-anomer
GXW83_RS04150	COG0745	RESPONSE REGULATOR receiver
GXW83_RS04155	COG2205	protein histidine kinase activity
GXW83_RS04160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GXW83_RS04160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GXW83_RS04185	COG2124	cytochrome p450
GXW83_RS04195	COG0148	phosphopyruvate hydratase activity
GXW83_RS04215	COG1252	NADH dehydrogenase
GXW83_RS04245	COG0183	Belongs to the thiolase family
GXW83_RS04270	COG1376	ErfK ybiS ycfS ynhG family protein
GXW83_RS04315	COG2318	DinB family
GXW83_RS04335	COG3654	unkown
GXW83_RS04355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GXW83_RS04370	COG1846	Transcriptional regulator
GXW83_RS04375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GXW83_RS04395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GXW83_RS04405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXW83_RS04415	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GXW83_RS04450	COG0789	Transcriptional regulator
GXW83_RS04465	COG1331	Highly conserved protein containing a thioredoxin domain
GXW83_RS04470	COG1309	transcriptional regulator
GXW83_RS04475	COG0477	Major facilitator Superfamily
GXW83_RS04485	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GXW83_RS04495	COG0436	Aminotransferase
GXW83_RS04510	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GXW83_RS04520	COG0251	oxidation-reduction process
GXW83_RS04530	COG0667	Aldo Keto reductase
GXW83_RS04535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GXW83_RS04540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GXW83_RS04555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GXW83_RS04560	COG0450	alkyl hydroperoxide reductase
GXW83_RS04590	COG0114	fumarate hydratase activity
GXW83_RS04620	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GXW83_RS04620	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GXW83_RS04645	COG0778	Nitroreductase
GXW83_RS04650	COG1722	exodeoxyribonuclease VII activity
GXW83_RS04655	COG1570	exodeoxyribonuclease VII activity
GXW83_RS04660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GXW83_RS04675	COG0012	GTP binding
GXW83_RS04705	COG0494	nUDIX hydrolase
GXW83_RS04720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GXW83_RS04725	COG1053	succinate dehydrogenase
GXW83_RS04755	COG0601	transmembrane transport
GXW83_RS04760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXW83_RS04770	COG4608	Belongs to the ABC transporter superfamily
GXW83_RS04805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXW83_RS04820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GXW83_RS04820	COG0515	serine threonine protein kinase
GXW83_RS04825	COG1131	(ABC) transporter
GXW83_RS04835	COG4585	Histidine kinase
GXW83_RS04840	COG2197	response regulator
GXW83_RS04875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXW83_RS04880	COG1611	Belongs to the LOG family
GXW83_RS04885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GXW83_RS04890	COG0519	Catalyzes the synthesis of GMP from XMP
GXW83_RS04895	COG1024	Enoyl-CoA hydratase
GXW83_RS04925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GXW83_RS04935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GXW83_RS04950	COG2239	Acts as a magnesium transporter
GXW83_RS04975	COG0613	PHP domain protein
GXW83_RS04995	COG0513	Belongs to the DEAD box helicase family
GXW83_RS05035	COG0438	transferase activity, transferring glycosyl groups
GXW83_RS05070	COG0210	DNA helicase
GXW83_RS05090	COG1136	(ABC) transporter
GXW83_RS05090	COG0577	efflux transmembrane transporter activity
GXW83_RS05100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXW83_RS05110	COG2188	Transcriptional regulator
GXW83_RS05140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GXW83_RS05180	COG3480	Lon protease (S16) C-terminal proteolytic domain
GXW83_RS05210	COG0586	Pfam SNARE associated Golgi protein
GXW83_RS05215	COG0483	inositol monophosphate 1-phosphatase activity
GXW83_RS05230	COG1162	GTPase activity
GXW83_RS05235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GXW83_RS05245	COG2135	peptidase activity
GXW83_RS05250	COG1595	DNA-templated transcription, initiation
GXW83_RS05255	COG5662	AntiSigma factor
GXW83_RS05265	COG0242	peptide deformylase activity
GXW83_RS05280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GXW83_RS05305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GXW83_RS05325	COG1349	DNA-binding transcription factor activity
GXW83_RS05330	COG4770	biotin carboxylase activity
GXW83_RS05345	COG0424	maF-like protein
GXW83_RS05355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GXW83_RS05360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GXW83_RS05360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GXW83_RS05365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GXW83_RS05375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GXW83_RS05380	COG2986	histidine ammonia-lyase
GXW83_RS05400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GXW83_RS05405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXW83_RS05415	COG1228	amidohydrolase
GXW83_RS05420	COG0745	RESPONSE REGULATOR receiver
GXW83_RS05425	COG2205	protein histidine kinase activity
GXW83_RS05450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXW83_RS05455	COG1832	CoA-binding protein
GXW83_RS05460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GXW83_RS05475	COG2986	histidine ammonia-lyase
GXW83_RS05485	COG0546	phosphoglycolate phosphatase activity
GXW83_RS05490	COG3842	ATPase activity
GXW83_RS05510	COG2188	Transcriptional regulator
GXW83_RS05525	COG1316	TRANSCRIPTIONal
GXW83_RS05545	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GXW83_RS05545	COG0778	Nitroreductase
GXW83_RS05550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GXW83_RS05555	COG2205	protein histidine kinase activity
GXW83_RS05560	COG0745	RESPONSE REGULATOR receiver
GXW83_RS05595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GXW83_RS05600	COG2835	tetraacyldisaccharide 4'-kinase activity
GXW83_RS05630	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GXW83_RS05655	COG0745	RESPONSE REGULATOR receiver
GXW83_RS05660	COG5002	protein histidine kinase activity
GXW83_RS05665	COG0823	Involved in the tonB-independent uptake of proteins
GXW83_RS05670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GXW83_RS05675	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GXW83_RS05680	COG2197	response regulator
GXW83_RS05685	COG3214	Protein conserved in bacteria
GXW83_RS05690	COG0438	transferase activity, transferring glycosyl groups
GXW83_RS05710	COG0653	protein targeting
GXW83_RS05735	COG1674	ftsk spoiiie
GXW83_RS05740	COG0515	serine threonine protein kinase
GXW83_RS05745	COG0515	serine threonine protein kinase
GXW83_RS05750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GXW83_RS05765	COG2884	Cell division ATP-binding protein ftsE
GXW83_RS05775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GXW83_RS05790	COG3973	AAA domain
GXW83_RS05800	COG0776	regulation of translation
GXW83_RS05805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GXW83_RS05810	COG1678	Uncharacterized ACR, COG1678
GXW83_RS05820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXW83_RS05850	COG1061	Type III restriction enzyme res subunit
GXW83_RS05870	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GXW83_RS05875	COG0277	FAD linked oxidase domain protein
GXW83_RS05895	COG5297	Belongs to the glycosyl hydrolase family 6
GXW83_RS05895	COG4733	cellulase activity
GXW83_RS05930	COG1335	isochorismatase
GXW83_RS05940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GXW83_RS05970	COG1234	tRNA 3'-trailer cleavage
GXW83_RS05975	COG1263	PTS System
GXW83_RS05980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GXW83_RS05985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GXW83_RS05990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GXW83_RS06025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GXW83_RS06030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXW83_RS06060	COG2733	membrane
GXW83_RS06065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GXW83_RS06070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXW83_RS06075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXW83_RS06100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GXW83_RS06130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GXW83_RS06135	COG0531	amino acid
GXW83_RS06160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GXW83_RS06170	COG3469	chitinase activity
GXW83_RS06175	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GXW83_RS06180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS06195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GXW83_RS06220	COG2203	Gaf domain
GXW83_RS06220	COG2199	diguanylate cyclase activity
GXW83_RS06220	COG2200	EAL domain
GXW83_RS06245	COG3903	Transcriptional regulator
GXW83_RS06245	COG3629	intracellular signal transduction
GXW83_RS06260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GXW83_RS06275	COG1619	proteins homologs of microcin C7 resistance protein MccF
GXW83_RS06285	COG0017	Asparaginyl-tRNA synthetase
GXW83_RS06290	COG0673	inositol 2-dehydrogenase activity
GXW83_RS06295	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GXW83_RS06300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXW83_RS06300	COG0072	phenylalanine-tRNA ligase activity
GXW83_RS06375	COG0406	alpha-ribazole phosphatase activity
GXW83_RS06380	COG0673	inositol 2-dehydrogenase activity
GXW83_RS06405	COG4608	Belongs to the ABC transporter superfamily
GXW83_RS06410	COG0444	Belongs to the ABC transporter superfamily
GXW83_RS06415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXW83_RS06420	COG0601	transmembrane transport
GXW83_RS06425	COG1609	Transcriptional regulator
GXW83_RS06450	COG0330	HflC and HflK could
GXW83_RS06460	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GXW83_RS06470	COG1011	Hydrolase
GXW83_RS06475	COG0589	response to stress
GXW83_RS06480	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS06495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GXW83_RS06500	COG1309	transcriptional regulator
GXW83_RS06505	COG3467	pyridoxamine 5'-phosphate
GXW83_RS06540	COG0583	DNA-binding transcription factor activity
GXW83_RS06550	COG1846	Transcriptional regulator
GXW83_RS06560	COG0386	Belongs to the glutathione peroxidase family
GXW83_RS06565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GXW83_RS06600	COG2261	transglycosylase associated protein
GXW83_RS06630	COG1846	Transcriptional regulator
GXW83_RS06635	COG1643	Atp-dependent helicase
GXW83_RS06640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GXW83_RS06650	COG0789	Transcriptional regulator
GXW83_RS06670	COG0629	single-stranded DNA binding
GXW83_RS06690	COG1376	ErfK ybiS ycfS ynhG family protein
GXW83_RS06695	COG0181	hydroxymethylbilane synthase activity
GXW83_RS06710	COG0586	Pfam SNARE associated Golgi protein
GXW83_RS06740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS06745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS06750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS06770	COG1278	Cold shock
GXW83_RS06780	COG3012	SEC-C Motif Domain Protein
GXW83_RS06825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GXW83_RS06835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GXW83_RS06850	COG1486	melibiose metabolic process
GXW83_RS06860	COG0668	transmembrane transport
GXW83_RS06895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GXW83_RS06900	COG1268	BioY protein
GXW83_RS06905	COG0698	ribose 5-phosphate isomerase
GXW83_RS06945	COG0494	nUDIX hydrolase
GXW83_RS07020	COG0544	peptidyl-prolyl cis-trans isomerase activity
GXW83_RS07025	COG0740	serine-type endopeptidase activity
GXW83_RS07030	COG0740	serine-type endopeptidase activity
GXW83_RS07035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GXW83_RS07040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GXW83_RS07050	COG0285	dihydrofolate synthase activity
GXW83_RS07060	COG0105	UTP biosynthetic process
GXW83_RS07065	COG1077	Cell shape determining protein MreB Mrl
GXW83_RS07080	COG0768	penicillin binding
GXW83_RS07085	COG0772	Belongs to the SEDS family
GXW83_RS07160	COG1530	ribonuclease E activity
GXW83_RS07165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GXW83_RS07170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GXW83_RS07175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GXW83_RS07180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GXW83_RS07185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GXW83_RS07195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GXW83_RS07210	COG0501	Belongs to the peptidase M48B family
GXW83_RS07225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GXW83_RS07235	COG0799	negative regulation of ribosome biogenesis
GXW83_RS07240	COG0588	phosphoglycerate mutase activity
GXW83_RS07295	COG0495	leucyl-tRNA aminoacylation
GXW83_RS07305	COG1307	EDD domain protein, DegV family
GXW83_RS07330	COG0268	Binds directly to 16S ribosomal RNA
GXW83_RS07335	COG2329	Antibiotic biosynthesis monooxygenase
GXW83_RS07345	COG0481	GTPase activity
GXW83_RS07395	COG0501	Belongs to the peptidase M48B family
GXW83_RS07400	COG1420	regulation of RNA biosynthetic process
GXW83_RS07405	COG0484	heat shock protein binding
GXW83_RS07415	COG4946	Tricorn protease homolog
GXW83_RS07415	COG0793	Belongs to the peptidase S41A family
GXW83_RS07420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GXW83_RS07430	COG0537	adenosine 5'-monophosphoramidase activity
GXW83_RS07435	COG1234	tRNA 3'-trailer cleavage
GXW83_RS07445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GXW83_RS07455	COG1473	amidohydrolase
GXW83_RS07465	COG1473	amidohydrolase
GXW83_RS07480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GXW83_RS07485	COG1609	Transcriptional regulator
GXW83_RS07490	COG0596	Alpha beta hydrolase
GXW83_RS07505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GXW83_RS07515	COG1381	Involved in DNA repair and RecF pathway recombination
GXW83_RS07520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GXW83_RS07530	COG0423	glycine-tRNA ligase activity
GXW83_RS07555	COG0477	Major facilitator Superfamily
GXW83_RS07570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GXW83_RS07570	COG0574	Belongs to the PEP-utilizing enzyme family
GXW83_RS07595	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GXW83_RS07605	COG0358	DNA primase activity
GXW83_RS07610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GXW83_RS07615	COG1070	Carbohydrate kinase
GXW83_RS07660	COG2130	NADP-dependent
GXW83_RS07680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXW83_RS07685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS07690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXW83_RS07715	COG0789	Transcriptional regulator
GXW83_RS07720	COG0667	Aldo Keto reductase
GXW83_RS07735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GXW83_RS07770	COG1940	carbohydrate kinase activity
GXW83_RS07795	COG1358	cellular component organization or biogenesis
GXW83_RS07835	COG5297	Belongs to the glycosyl hydrolase family 6
GXW83_RS07835	COG4733	cellulase activity
GXW83_RS07845	COG2815	serine threonine protein kinase
GXW83_RS07845	COG0515	serine threonine protein kinase
GXW83_RS07855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GXW83_RS07895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GXW83_RS07910	COG0667	Aldo Keto reductase
GXW83_RS07930	COG2124	cytochrome p450
GXW83_RS07935	COG0183	Belongs to the thiolase family
GXW83_RS07970	COG1309	transcriptional regulator
GXW83_RS07975	COG0438	transferase activity, transferring glycosyl groups
GXW83_RS07980	COG2226	methyltransferase
GXW83_RS07995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS08005	COG0860	N-Acetylmuramoyl-L-alanine amidase
GXW83_RS08015	COG3510	cephalosporin hydroxylase
GXW83_RS08025	COG4977	sequence-specific DNA binding
GXW83_RS08035	COG3511	phospholipase C
GXW83_RS08040	COG0183	Belongs to the thiolase family
GXW83_RS08045	COG2030	dehydratase
GXW83_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS08065	COG2267	carboxylic ester hydrolase activity
GXW83_RS08070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GXW83_RS08085	COG3022	response to hydroperoxide
GXW83_RS08090	COG0557	exoribonuclease II activity
GXW83_RS08145	COG0525	valine-tRNA ligase activity
GXW83_RS08180	COG1011	Hydrolase
GXW83_RS08285	COG4974	Belongs to the 'phage' integrase family
GXW83_RS08350	COG0017	Asparaginyl-tRNA synthetase
GXW83_RS08360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GXW83_RS08375	COG0736	holo-[acyl-carrier-protein] synthase activity
GXW83_RS08410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GXW83_RS08445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS08455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXW83_RS08480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GXW83_RS08495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GXW83_RS08510	COG3469	chitinase activity
GXW83_RS08530	COG5416	Lipopolysaccharide assembly protein A domain
GXW83_RS08535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GXW83_RS08590	COG0714	Associated with various cellular activities
GXW83_RS08620	COG1994	Peptidase M50
GXW83_RS08665	COG4106	trans-aconitate 2-methyltransferase activity
GXW83_RS08710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXW83_RS08715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GXW83_RS08730	COG0174	glutamine synthetase
GXW83_RS08745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GXW83_RS08755	COG1584	GPR1 FUN34 yaaH family protein
GXW83_RS08770	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS08770	COG0604	alcohol dehydrogenase
GXW83_RS08770	COG3321	synthase
GXW83_RS08775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXW83_RS08815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GXW83_RS08820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GXW83_RS08825	COG1595	DNA-templated transcription, initiation
GXW83_RS08860	COG4115	mRNA cleavage
GXW83_RS08865	COG2161	toxin-antitoxin pair type II binding
GXW83_RS08895	COG0321	lipoyl(octanoyl) transferase activity
GXW83_RS08900	COG0667	Aldo Keto reductase
GXW83_RS08905	COG1309	transcriptional regulator
GXW83_RS08935	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXW83_RS08940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GXW83_RS08945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GXW83_RS08950	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GXW83_RS08955	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GXW83_RS08975	COG0667	Aldo Keto reductase
GXW83_RS08980	COG2226	methyltransferase
GXW83_RS09000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GXW83_RS09010	COG1522	sequence-specific DNA binding
GXW83_RS09015	COG0076	glutamate decarboxylase activity
GXW83_RS09040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GXW83_RS09050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GXW83_RS09055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GXW83_RS09065	COG1376	ErfK ybiS ycfS ynhG family protein
GXW83_RS09070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GXW83_RS09075	COG0723	plastoquinol--plastocyanin reductase activity
GXW83_RS09085	COG1845	cytochrome c oxidase, subunit III
GXW83_RS09095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GXW83_RS09100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GXW83_RS09125	COG0791	NLP P60 protein
GXW83_RS09125	COG1388	LysM domain
GXW83_RS09125	COG3103	Sh3 type 3 domain protein
GXW83_RS09130	COG0791	NLP P60 protein
GXW83_RS09130	COG0741	lytic transglycosylase activity
GXW83_RS09150	COG0438	transferase activity, transferring glycosyl groups
GXW83_RS09170	COG0003	Pfam Anion-transporting ATPase
GXW83_RS09180	COG1940	carbohydrate kinase activity
GXW83_RS09210	COG2197	response regulator
GXW83_RS09215	COG0205	6-phosphofructokinase activity
GXW83_RS09220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GXW83_RS09220	COG1017	nitric oxide dioxygenase activity
GXW83_RS09230	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GXW83_RS09235	COG0243	molybdopterin cofactor binding
GXW83_RS09240	COG2193	ferroxidase activity
GXW83_RS09245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GXW83_RS09260	COG2815	serine threonine protein kinase
GXW83_RS09260	COG0515	serine threonine protein kinase
GXW83_RS09265	COG2022	thiamine diphosphate biosynthetic process
GXW83_RS09275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXW83_RS09275	COG2022	thiamine diphosphate biosynthetic process
GXW83_RS09280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GXW83_RS09290	COG0352	thiamine-phosphate diphosphorylase activity
GXW83_RS09315	COG1309	transcriptional regulator
GXW83_RS09325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GXW83_RS09330	COG2364	Membrane
GXW83_RS09340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GXW83_RS09360	COG0714	Associated with various cellular activities
GXW83_RS09370	COG0275	rRNA processing
GXW83_RS09380	COG0768	penicillin binding
GXW83_RS09385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GXW83_RS09390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GXW83_RS09395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GXW83_RS09400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GXW83_RS09410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GXW83_RS09420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GXW83_RS09430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GXW83_RS09435	COG1799	cell septum assembly
GXW83_RS09445	COG3599	regulation of cell shape
GXW83_RS09450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GXW83_RS09460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GXW83_RS09500	COG0587	DNA-directed DNA polymerase activity
GXW83_RS09530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GXW83_RS09535	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GXW83_RS09540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GXW83_RS09545	COG0131	Imidazoleglycerol-phosphate dehydratase
GXW83_RS09555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GXW83_RS09560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GXW83_RS09565	COG0251	oxidation-reduction process
GXW83_RS09570	COG0107	imidazoleglycerol-phosphate synthase activity
GXW83_RS09580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GXW83_RS09585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GXW83_RS09605	COG0134	indole-3-glycerol-phosphate synthase activity
GXW83_RS09615	COG0133	tryptophan synthase activity
GXW83_RS09620	COG0159	tryptophan synthase activity
GXW83_RS09640	COG2197	response regulator
GXW83_RS09645	COG4585	Histidine kinase
GXW83_RS09655	COG1136	(ABC) transporter
GXW83_RS09670	COG0070	glutamate synthase
GXW83_RS09670	COG0069	glutamate synthase activity
GXW83_RS09670	COG0067	glutamate synthase
GXW83_RS09700	COG0531	amino acid
GXW83_RS09705	COG0531	amino acid
GXW83_RS09720	COG2050	protein possibly involved in aromatic compounds catabolism
GXW83_RS09730	COG2226	methyltransferase
GXW83_RS09740	COG2409	Drug exporters of the RND superfamily
GXW83_RS09745	COG0237	dephospho-CoA kinase activity
GXW83_RS09815	COG2409	Drug exporters of the RND superfamily
GXW83_RS09830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GXW83_RS09835	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GXW83_RS09855	COG0529	Catalyzes the synthesis of activated sulfate
GXW83_RS09860	COG0175	sulfate reduction
GXW83_RS09870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GXW83_RS09875	COG1619	proteins homologs of microcin C7 resistance protein MccF
GXW83_RS09880	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GXW83_RS09895	COG1162	GTPase activity
GXW83_RS09915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GXW83_RS09940	COG1309	transcriptional regulator
GXW83_RS09975	COG2154	pterin-4-alpha-carbinolamine dehydratase
GXW83_RS09980	COG1324	tolerance protein
GXW83_RS09985	COG2957	Belongs to the agmatine deiminase family
GXW83_RS09990	COG0804	urea catabolic process
GXW83_RS09995	COG0831	urea catabolic process
GXW83_RS09995	COG0832	Belongs to the urease beta subunit family
GXW83_RS10030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GXW83_RS10040	COG1414	Transcriptional regulator
GXW83_RS10085	COG3622	Belongs to the hyi family
GXW83_RS10090	COG2084	Dehydrogenase
GXW83_RS10095	COG3960	tartronate-semialdehyde synthase activity
GXW83_RS10100	COG1929	Belongs to the glycerate kinase type-1 family
GXW83_RS10105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GXW83_RS10110	COG4266	Belongs to the allantoicase family
GXW83_RS10135	COG2252	PERMEase
GXW83_RS10155	COG0339	signal peptide processing
GXW83_RS10160	COG3835	regulator
GXW83_RS10165	COG1940	carbohydrate kinase activity
GXW83_RS10175	COG0671	phosphoesterase, PA-phosphatase related
GXW83_RS10180	COG0586	Pfam SNARE associated Golgi protein
GXW83_RS10195	COG2755	lipolytic protein G-D-S-L family
GXW83_RS10280	COG2182	Extracellular solute-binding protein
GXW83_RS10285	COG1175	transmembrane transport
GXW83_RS10290	COG3833	ABC-type maltose transport systems, permease component
GXW83_RS10295	COG0366	Alpha amylase catalytic
GXW83_RS10355	COG0726	polysaccharide deacetylase
GXW83_RS10400	COG1802	Transcriptional regulator
GXW83_RS10410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GXW83_RS10415	COG0540	Belongs to the ATCase OTCase family
GXW83_RS10420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GXW83_RS10430	COG0505	Belongs to the CarA family
GXW83_RS10435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GXW83_RS10440	COG0167	dihydroorotate dehydrogenase activity
GXW83_RS10445	COG0543	2 iron, 2 sulfur cluster binding
GXW83_RS10450	COG0167	dihydroorotate dehydrogenase activity
GXW83_RS10455	COG0284	orotidine-5'-phosphate decarboxylase activity
GXW83_RS10465	COG0194	GDP metabolic process
GXW83_RS10480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GXW83_RS10485	COG0393	Putative heavy-metal-binding
GXW83_RS10500	COG0242	peptide deformylase activity
GXW83_RS10505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GXW83_RS10515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GXW83_RS10550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GXW83_RS10555	COG4585	Histidine kinase
GXW83_RS10570	COG3201	nicotinamide mononucleotide transporter
GXW83_RS10575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GXW83_RS10575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GXW83_RS10580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GXW83_RS10585	COG0140	phosphoribosyl-ATP diphosphatase activity
GXW83_RS10590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GXW83_RS10610	COG4152	abc transporter atp-binding protein
GXW83_RS10630	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS10670	COG1216	Glycosyl transferase, family 2
GXW83_RS10685	COG0259	pyridoxamine-phosphate oxidase activity
GXW83_RS10715	COG1309	transcriptional regulator
GXW83_RS10730	COG3345	alpha-galactosidase
GXW83_RS10745	COG0708	Exodeoxyribonuclease III
GXW83_RS10765	COG0488	(ABC) transporter
GXW83_RS10770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXW83_RS10790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXW83_RS10810	COG3511	phospholipase C
GXW83_RS10815	COG0387	Pfam Sodium calcium exchanger
GXW83_RS10965	COG1012	belongs to the aldehyde dehydrogenase family
GXW83_RS10995	COG0842	Transport permease protein
GXW83_RS11020	COG0254	rRNA binding
GXW83_RS11035	COG2353	YceI-like domain
GXW83_RS11045	COG0477	Major facilitator Superfamily
GXW83_RS11050	COG1846	Transcriptional regulator
GXW83_RS11055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GXW83_RS11080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GXW83_RS11115	COG0708	Exodeoxyribonuclease III
GXW83_RS11165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GXW83_RS11170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GXW83_RS11190	COG2124	cytochrome p450
GXW83_RS11225	COG1309	transcriptional regulator
GXW83_RS11230	COG1946	Acyl-CoA thioesterase
GXW83_RS11240	COG1024	Enoyl-CoA hydratase
GXW83_RS11245	COG0076	glutamate decarboxylase activity
GXW83_RS11250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GXW83_RS11260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GXW83_RS11285	COG2188	Transcriptional regulator
GXW83_RS11290	COG1940	carbohydrate kinase activity
GXW83_RS11305	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GXW83_RS11310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GXW83_RS11315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GXW83_RS11355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GXW83_RS11360	COG0205	6-phosphofructokinase activity
GXW83_RS11365	COG3442	glutamine amidotransferase
GXW83_RS11370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GXW83_RS11375	COG0242	peptide deformylase activity
GXW83_RS11385	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS11425	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS11440	COG1175	transmembrane transport
GXW83_RS11445	COG0395	ABC-type sugar transport system, permease component
GXW83_RS11450	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GXW83_RS11460	COG0477	Major facilitator Superfamily
GXW83_RS11475	COG1309	transcriptional regulator
GXW83_RS11490	COG1105	Belongs to the carbohydrate kinase PfkB family
GXW83_RS11495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GXW83_RS11505	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GXW83_RS11510	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GXW83_RS11515	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GXW83_RS11525	COG1132	(ABC) transporter
GXW83_RS11580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GXW83_RS11610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GXW83_RS11620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GXW83_RS11620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GXW83_RS11635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GXW83_RS11655	COG1695	Transcriptional regulator
GXW83_RS11665	COG0110	maltose O-acetyltransferase activity
GXW83_RS11670	COG2223	nitrite transmembrane transporter activity
GXW83_RS11700	COG1349	DNA-binding transcription factor activity
GXW83_RS11710	COG0464	growth
GXW83_RS11735	COG1410	methionine synthase
GXW83_RS11735	COG0646	methionine synthase
GXW83_RS11740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXW83_RS11760	COG0517	IMP dehydrogenase activity
GXW83_RS11760	COG1994	Peptidase M50
GXW83_RS11780	COG1222	aaa ATPase
GXW83_RS11785	COG4122	O-methyltransferase activity
GXW83_RS11800	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GXW83_RS11805	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GXW83_RS11810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GXW83_RS11845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GXW83_RS11850	COG0805	protein transport
GXW83_RS11880	COG3360	Dodecin
GXW83_RS11890	COG2378	regulation of single-species biofilm formation
GXW83_RS11900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GXW83_RS11910	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GXW83_RS11930	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS12000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GXW83_RS12005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GXW83_RS12010	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GXW83_RS12015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GXW83_RS12020	COG5002	protein histidine kinase activity
GXW83_RS12025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GXW83_RS12030	COG0072	phenylalanine-tRNA ligase activity
GXW83_RS12030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXW83_RS12035	COG0640	Transcriptional regulator
GXW83_RS12050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GXW83_RS12055	COG0494	nUDIX hydrolase
GXW83_RS12065	COG1349	DNA-binding transcription factor activity
GXW83_RS12070	COG0587	DNA-directed DNA polymerase activity
GXW83_RS12075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GXW83_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS12095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GXW83_RS12100	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GXW83_RS12105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GXW83_RS12110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GXW83_RS12115	COG1438	arginine binding
GXW83_RS12120	COG0137	argininosuccinate synthase activity
GXW83_RS12125	COG0165	Argininosuccinate lyase
GXW83_RS12150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GXW83_RS12155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GXW83_RS12155	COG1648	precorrin-2 dehydrogenase activity
GXW83_RS12165	COG0515	serine threonine protein kinase
GXW83_RS12165	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GXW83_RS12205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GXW83_RS12245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GXW83_RS12260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GXW83_RS12285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GXW83_RS12290	COG1560	Kdo2-lipid A biosynthetic process
GXW83_RS12295	COG0438	transferase activity, transferring glycosyl groups
GXW83_RS12305	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GXW83_RS12310	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GXW83_RS12315	COG0217	transcriptional regulatory protein
GXW83_RS12320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GXW83_RS12325	COG0632	four-way junction helicase activity
GXW83_RS12330	COG2255	four-way junction helicase activity
GXW83_RS12340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GXW83_RS12345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GXW83_RS12350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GXW83_RS12355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GXW83_RS12360	COG1196	nuclear chromosome segregation
GXW83_RS12365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GXW83_RS12375	COG0124	histidyl-tRNA synthetase
GXW83_RS12380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GXW83_RS12400	COG0395	ABC-type sugar transport system, permease component
GXW83_RS12415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GXW83_RS12435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GXW83_RS12440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GXW83_RS12450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GXW83_RS12455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GXW83_RS12460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GXW83_RS12465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GXW83_RS12470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GXW83_RS12480	COG0006	proline dipeptidase activity
GXW83_RS12485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GXW83_RS12490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GXW83_RS12515	COG0300	oxidoreductase activity
GXW83_RS12545	COG4585	Histidine kinase
GXW83_RS12550	COG2197	response regulator
GXW83_RS12650	COG0601	transmembrane transport
GXW83_RS12660	COG0444	Belongs to the ABC transporter superfamily
GXW83_RS12685	COG0076	glutamate decarboxylase activity
GXW83_RS12690	COG1309	transcriptional regulator
GXW83_RS12700	COG1134	teichoic acid transport
GXW83_RS12700	COG1388	LysM domain
GXW83_RS12705	COG1562	ergosterol biosynthetic process
GXW83_RS12715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GXW83_RS12735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GXW83_RS12755	COG0671	phosphoesterase, PA-phosphatase related
GXW83_RS12780	COG1309	transcriptional regulator
GXW83_RS12800	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS12835	COG2072	flavoprotein involved in K transport
GXW83_RS12845	COG0656	L-ascorbic acid biosynthetic process
GXW83_RS12860	COG0588	phosphoglycerate mutase activity
GXW83_RS12865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GXW83_RS12890	COG4948	Mandelate Racemase Muconate Lactonizing
GXW83_RS12895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXW83_RS12900	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS12910	COG1414	Transcriptional regulator
GXW83_RS12920	COG0395	ABC-type sugar transport system, permease component
GXW83_RS12945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GXW83_RS12975	COG0667	Aldo Keto reductase
GXW83_RS12980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS12995	COG2909	trisaccharide binding
GXW83_RS12995	COG2909	trisaccharide binding
GXW83_RS13010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXW83_RS13030	COG2409	Drug exporters of the RND superfamily
GXW83_RS13075	COG0215	cysteine-tRNA ligase activity
GXW83_RS13085	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GXW83_RS13105	COG4122	O-methyltransferase activity
GXW83_RS13130	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS13135	COG0515	serine threonine protein kinase
GXW83_RS13140	COG2070	2-Nitropropane dioxygenase
GXW83_RS13185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GXW83_RS13210	COG1902	pentaerythritol trinitrate reductase activity
GXW83_RS13210	COG0446	pyridine nucleotide-disulphide oxidoreductase
GXW83_RS13225	COG3408	Glycogen debranching enzyme
GXW83_RS13225	COG3119	arylsulfatase activity
GXW83_RS13245	COG0586	Pfam SNARE associated Golgi protein
GXW83_RS13265	COG0022	dehydrogenase e1 component
GXW83_RS13270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GXW83_RS13285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXW83_RS13300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXW83_RS13320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GXW83_RS13345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXW83_RS13350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS13360	COG2091	lysine biosynthetic process via aminoadipic acid
GXW83_RS13375	COG2814	Major facilitator Superfamily
GXW83_RS13390	COG0446	pyridine nucleotide-disulphide oxidoreductase
GXW83_RS13415	COG0784	Response regulator, receiver
GXW83_RS13435	COG2837	iron assimilation
GXW83_RS13440	COG1077	Cell shape determining protein MreB Mrl
GXW83_RS13475	COG0584	glycerophosphoryl diester phosphodiesterase
GXW83_RS13485	COG2208	phosphoserine phosphatase activity
GXW83_RS13495	COG0531	amino acid
GXW83_RS13505	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GXW83_RS13530	COG3537	Alpha-1,2-mannosidase
GXW83_RS13540	COG0183	Belongs to the thiolase family
GXW83_RS13545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GXW83_RS13565	COG0640	Transcriptional regulator
GXW83_RS13600	COG0175	sulfate reduction
GXW83_RS13615	COG3328	transposase activity
GXW83_RS13655	COG2095	MarC family integral membrane protein
GXW83_RS13670	COG0667	Aldo Keto reductase
GXW83_RS13680	COG0515	serine threonine protein kinase
GXW83_RS13680	COG2815	serine threonine protein kinase
GXW83_RS13710	COG2409	Drug exporters of the RND superfamily
GXW83_RS13720	COG3903	Transcriptional regulator
GXW83_RS13720	COG3629	intracellular signal transduction
GXW83_RS13775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GXW83_RS13780	COG3903	Transcriptional regulator
GXW83_RS13780	COG3629	intracellular signal transduction
GXW83_RS13840	COG0655	NAD(P)H dehydrogenase (quinone) activity
GXW83_RS13845	COG1733	regulation of RNA biosynthetic process
GXW83_RS13865	COG1846	Transcriptional regulator
GXW83_RS13870	COG0604	alcohol dehydrogenase
GXW83_RS13885	COG0531	amino acid
GXW83_RS13895	COG2409	Drug exporters of the RND superfamily
GXW83_RS13900	COG0583	DNA-binding transcription factor activity
GXW83_RS13935	COG0726	polysaccharide deacetylase
GXW83_RS13940	COG0726	polysaccharide deacetylase
GXW83_RS13970	COG0431	NADPH-dependent FMN reductase
GXW83_RS13975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS14035	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GXW83_RS14055	COG0300	oxidoreductase activity
GXW83_RS14065	COG0477	Major facilitator Superfamily
GXW83_RS14115	COG0326	Molecular chaperone. Has ATPase activity
GXW83_RS14150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXW83_RS14160	COG0028	Belongs to the TPP enzyme family
GXW83_RS14185	COG2146	nitrite reductase [NAD(P)H] activity
GXW83_RS14190	COG0546	phosphoglycolate phosphatase activity
GXW83_RS14195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS14205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GXW83_RS14210	COG1834	amidinotransferase
GXW83_RS14225	COG2890	protein-(glutamine-N5) methyltransferase activity
GXW83_RS14280	COG1511	domain protein
GXW83_RS14285	COG1131	(ABC) transporter
GXW83_RS14305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GXW83_RS14325	COG1349	DNA-binding transcription factor activity
GXW83_RS14340	COG0395	ABC-type sugar transport system, permease component
GXW83_RS14345	COG1063	alcohol dehydrogenase
GXW83_RS14360	COG0667	Aldo Keto reductase
GXW83_RS14380	COG0583	DNA-binding transcription factor activity
GXW83_RS14385	COG1073	alpha beta
GXW83_RS14425	COG1461	Dihydroxyacetone kinase
GXW83_RS14430	COG2376	Dihydroxyacetone kinase
GXW83_RS14435	COG0628	permease
GXW83_RS14455	COG1609	Transcriptional regulator
GXW83_RS14470	COG1609	Transcriptional regulator
GXW83_RS14475	COG1172	Belongs to the binding-protein-dependent transport system permease family
GXW83_RS14480	COG1172	Belongs to the binding-protein-dependent transport system permease family
GXW83_RS14485	COG1129	ABC transporter
GXW83_RS14490	COG1879	ABC-type sugar transport system periplasmic component
GXW83_RS14500	COG0596	Alpha beta hydrolase
GXW83_RS14515	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GXW83_RS14565	COG0477	Major facilitator Superfamily
GXW83_RS14590	COG0574	Belongs to the PEP-utilizing enzyme family
GXW83_RS14590	COG3848	Pyruvate phosphate dikinase
GXW83_RS14595	COG2197	response regulator
GXW83_RS14600	COG4585	Histidine kinase
GXW83_RS14625	COG3251	PFAM MbtH domain protein
GXW83_RS14645	COG2124	cytochrome p450
GXW83_RS14650	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS14655	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS14685	COG1295	ribonuclease BN
GXW83_RS14725	COG1132	(ABC) transporter
GXW83_RS14740	COG3903	Transcriptional regulator
GXW83_RS14740	COG3629	intracellular signal transduction
GXW83_RS14745	COG1595	DNA-templated transcription, initiation
GXW83_RS14760	COG1674	ftsk spoiiie
GXW83_RS14815	COG2205	protein histidine kinase activity
GXW83_RS14840	COG2226	methyltransferase
GXW83_RS14845	COG1435	thymidine kinase activity
GXW83_RS14860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GXW83_RS14875	COG2186	Transcriptional regulator
GXW83_RS14880	COG0028	Belongs to the TPP enzyme family
GXW83_RS14885	COG0069	glutamate synthase activity
GXW83_RS14930	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS14955	COG2267	carboxylic ester hydrolase activity
GXW83_RS14985	COG0297	glycogen (starch) synthase activity
GXW83_RS15000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GXW83_RS15005	COG0577	efflux transmembrane transporter activity
GXW83_RS15005	COG1136	(ABC) transporter
GXW83_RS15010	COG1136	(ABC) transporter
GXW83_RS15010	COG0577	efflux transmembrane transporter activity
GXW83_RS15035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GXW83_RS15055	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GXW83_RS15065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GXW83_RS15120	COG0477	Major facilitator Superfamily
GXW83_RS15195	COG0300	oxidoreductase activity
GXW83_RS15200	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS15280	COG0515	serine threonine protein kinase
GXW83_RS15305	COG3290	protein histidine kinase activity
GXW83_RS15320	COG3291	Pkd domain containing protein
GXW83_RS15325	COG0583	DNA-binding transcription factor activity
GXW83_RS15330	COG0673	inositol 2-dehydrogenase activity
GXW83_RS15335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GXW83_RS15375	COG1252	NADH dehydrogenase
GXW83_RS15380	COG1271	oxidase subunit
GXW83_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS15435	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GXW83_RS15440	COG4221	oxidoreductase activity
GXW83_RS15475	COG2197	response regulator
GXW83_RS15480	COG4585	Histidine kinase
GXW83_RS15495	COG0515	serine threonine protein kinase
GXW83_RS15505	COG0745	RESPONSE REGULATOR receiver
GXW83_RS15665	COG3328	transposase activity
GXW83_RS15745	COG3328	transposase activity
GXW83_RS15795	COG0667	Aldo Keto reductase
GXW83_RS15905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GXW83_RS15925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GXW83_RS15935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXW83_RS15940	COG0492	ferredoxin-NADP+ reductase activity
GXW83_RS15945	COG0477	Major facilitator Superfamily
GXW83_RS15955	COG4279	zinc finger
GXW83_RS15960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GXW83_RS15970	COG1799	cell septum assembly
GXW83_RS15975	COG0738	Major facilitator superfamily
GXW83_RS15995	COG3842	ATPase activity
GXW83_RS16015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXW83_RS16020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXW83_RS16065	COG2813	Specifically methylates the guanine in position
GXW83_RS16075	COG1302	Protein conserved in bacteria
GXW83_RS16120	COG2050	protein possibly involved in aromatic compounds catabolism
GXW83_RS16125	COG1643	Atp-dependent helicase
GXW83_RS16130	COG0183	Belongs to the thiolase family
GXW83_RS16135	COG1024	Enoyl-CoA hydratase
GXW83_RS16135	COG1250	3-hydroxyacyl-CoA dehydrogenase
GXW83_RS16175	COG1349	DNA-binding transcription factor activity
GXW83_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS16230	COG0747	negative chemotaxis
GXW83_RS16255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GXW83_RS16305	COG5002	protein histidine kinase activity
GXW83_RS16325	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GXW83_RS16335	COG1802	Transcriptional regulator
GXW83_RS16355	COG1132	(ABC) transporter
GXW83_RS16360	COG1132	(ABC) transporter
GXW83_RS16370	COG0515	serine threonine protein kinase
GXW83_RS16395	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GXW83_RS16435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GXW83_RS16470	COG0475	glutathione-regulated potassium exporter activity
GXW83_RS16475	COG3251	PFAM MbtH domain protein
GXW83_RS16490	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS16515	COG1191	sigma factor activity
GXW83_RS16545	COG2198	Histidine kinase
GXW83_RS16545	COG5002	protein histidine kinase activity
GXW83_RS16545	COG0784	Response regulator, receiver
GXW83_RS16555	COG2172	sigma factor antagonist activity
GXW83_RS16560	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS16565	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS16575	COG0784	Response regulator, receiver
GXW83_RS16590	COG1191	sigma factor activity
GXW83_RS16610	COG5002	protein histidine kinase activity
GXW83_RS16610	COG2205	protein histidine kinase activity
GXW83_RS16610	COG0784	Response regulator, receiver
GXW83_RS16630	COG2271	Major facilitator Superfamily
GXW83_RS16635	COG2017	converts alpha-aldose to the beta-anomer
GXW83_RS16645	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS16665	COG1191	sigma factor activity
GXW83_RS16690	COG1472	Belongs to the glycosyl hydrolase 3 family
GXW83_RS16710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GXW83_RS16725	COG0702	epimerase
GXW83_RS16755	COG3265	gluconokinase activity
GXW83_RS16760	COG0784	Response regulator, receiver
GXW83_RS16765	COG4251	negative regulation of phosphorylation
GXW83_RS16805	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS16820	COG2770	Histidine kinase
GXW83_RS16820	COG2208	phosphoserine phosphatase activity
GXW83_RS16825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GXW83_RS16830	COG1472	Belongs to the glycosyl hydrolase 3 family
GXW83_RS16870	COG0464	growth
GXW83_RS16890	COG1674	ftsk spoiiie
GXW83_RS16900	COG2226	methyltransferase
GXW83_RS16905	COG3104	oligopeptide transport
GXW83_RS16925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GXW83_RS16935	COG0179	Fumarylacetoacetate (FAA) hydrolase
GXW83_RS16940	COG3473	Maleate cis-trans isomerase
GXW83_RS16955	COG2084	Dehydrogenase
GXW83_RS16970	COG2755	lipolytic protein G-D-S-L family
GXW83_RS16970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GXW83_RS16985	COG0300	oxidoreductase activity
GXW83_RS16990	COG0584	glycerophosphoryl diester phosphodiesterase
GXW83_RS17005	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GXW83_RS17015	COG1793	dna ligase
GXW83_RS17025	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS17050	COG0477	Major facilitator Superfamily
GXW83_RS17085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXW83_RS17100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXW83_RS17125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GXW83_RS17135	COG3903	Transcriptional regulator
GXW83_RS17135	COG3629	intracellular signal transduction
GXW83_RS17180	COG1309	transcriptional regulator
GXW83_RS17185	COG0667	Aldo Keto reductase
GXW83_RS17190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GXW83_RS17245	COG0477	Major facilitator Superfamily
GXW83_RS17275	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS17280	COG2208	phosphoserine phosphatase activity
GXW83_RS17280	COG2770	Histidine kinase
GXW83_RS17285	COG0596	Alpha beta hydrolase
GXW83_RS17315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GXW83_RS17380	COG0330	HflC and HflK could
GXW83_RS17385	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GXW83_RS17390	COG0501	Belongs to the peptidase M48B family
GXW83_RS17405	COG3237	CsbD-like
GXW83_RS17425	COG2172	sigma factor antagonist activity
GXW83_RS17430	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS17435	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS17455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXW83_RS17485	COG0784	Response regulator, receiver
GXW83_RS17495	COG4251	negative regulation of phosphorylation
GXW83_RS17555	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GXW83_RS17595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GXW83_RS17600	COG2267	carboxylic ester hydrolase activity
GXW83_RS17630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXW83_RS17755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXW83_RS17850	COG0583	DNA-binding transcription factor activity
GXW83_RS17895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GXW83_RS17910	COG0328	RNA-DNA hybrid ribonuclease activity
GXW83_RS17915	COG0667	Aldo Keto reductase
GXW83_RS17950	COG0640	Transcriptional regulator
GXW83_RS17960	COG1802	Transcriptional regulator
GXW83_RS17985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXW83_RS18000	COG0006	proline dipeptidase activity
GXW83_RS18005	COG4934	collagen metabolic process
GXW83_RS18010	COG0583	DNA-binding transcription factor activity
GXW83_RS18025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXW83_RS18030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXW83_RS18070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXW83_RS18075	COG2814	Major facilitator Superfamily
GXW83_RS18090	COG0667	Aldo Keto reductase
GXW83_RS18130	COG0583	DNA-binding transcription factor activity
GXW83_RS18150	COG0702	epimerase
GXW83_RS18155	COG2011	ABC-type metal ion transport system permease component
GXW83_RS18160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GXW83_RS18220	COG1982	Orn Lys Arg decarboxylase major
GXW83_RS18230	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GXW83_RS18250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GXW83_RS18275	COG3340	Belongs to the peptidase S51 family
GXW83_RS18310	COG2182	Extracellular solute-binding protein
GXW83_RS18315	COG1175	transmembrane transport
GXW83_RS18320	COG0395	ABC-type sugar transport system, permease component
GXW83_RS18325	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GXW83_RS18330	COG2188	Transcriptional regulator
GXW83_RS18365	COG0701	Predicted permease
GXW83_RS18395	COG1595	DNA-templated transcription, initiation
GXW83_RS18480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS18485	COG4608	Belongs to the ABC transporter superfamily
GXW83_RS18495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXW83_RS18500	COG0601	transmembrane transport
GXW83_RS18555	COG3104	oligopeptide transport
GXW83_RS18575	COG4989	oxidoreductase activity
GXW83_RS18580	COG0651	ATP synthesis coupled electron transport
GXW83_RS18585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS18595	COG0477	Major facilitator Superfamily
GXW83_RS18600	COG1132	(ABC) transporter
GXW83_RS18605	COG0829	nickel cation binding
GXW83_RS18610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GXW83_RS18620	COG0804	urea catabolic process
GXW83_RS18625	COG0832	Belongs to the urease beta subunit family
GXW83_RS18630	COG0831	urea catabolic process
GXW83_RS18660	COG1796	DNA polymerase
GXW83_RS18660	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GXW83_RS18670	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GXW83_RS18710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GXW83_RS18715	COG2814	Major facilitator Superfamily
GXW83_RS18740	COG1335	isochorismatase
GXW83_RS18775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GXW83_RS18785	COG2814	Major facilitator Superfamily
GXW83_RS18815	COG0765	amino acid transport
GXW83_RS18875	COG1250	3-hydroxyacyl-CoA dehydrogenase
GXW83_RS18915	COG3572	ergothioneine biosynthetic process
GXW83_RS18920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXW83_RS18925	COG0121	glutamine amidotransferase
GXW83_RS18930	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GXW83_RS18960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GXW83_RS18975	COG3191	aminopeptidase activity
GXW83_RS19030	COG1247	-acetyltransferase
GXW83_RS19060	COG0492	ferredoxin-NADP+ reductase activity
GXW83_RS19105	COG1215	transferase activity, transferring glycosyl groups
GXW83_RS19110	COG5001	Diguanylate cyclase
GXW83_RS19185	COG4977	sequence-specific DNA binding
GXW83_RS19195	COG0028	Belongs to the TPP enzyme family
GXW83_RS19215	COG0180	Tryptophanyl-tRNA synthetase
GXW83_RS19220	COG3619	membrane
GXW83_RS19235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GXW83_RS19255	COG1739	Uncharacterized protein family UPF0029
GXW83_RS19280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GXW83_RS19285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXW83_RS19295	COG1414	Transcriptional regulator
GXW83_RS19300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GXW83_RS19305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GXW83_RS19310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GXW83_RS19320	COG2755	lipolytic protein G-D-S-L family
GXW83_RS19350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GXW83_RS19355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GXW83_RS19360	COG1984	allophanate hydrolase subunit 2
GXW83_RS19370	COG0860	N-Acetylmuramoyl-L-alanine amidase
GXW83_RS19415	COG1024	Enoyl-CoA hydratase
GXW83_RS19440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GXW83_RS19460	COG1609	Transcriptional regulator
GXW83_RS19475	COG0601	transmembrane transport
GXW83_RS19480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXW83_RS19485	COG0444	Belongs to the ABC transporter superfamily
GXW83_RS19490	COG1764	response to oxidative stress
GXW83_RS19495	COG1846	Transcriptional regulator
GXW83_RS19505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GXW83_RS19515	COG3396	Phenylacetate-CoA oxygenase
GXW83_RS19520	COG3460	Phenylacetate-CoA oxygenase
GXW83_RS19525	COG3396	Phenylacetate-CoA oxygenase
GXW83_RS19530	COG2304	oxidoreductase activity
GXW83_RS19545	COG0477	Major facilitator Superfamily
GXW83_RS19570	COG0346	lactoylglutathione lyase activity
GXW83_RS19595	COG2197	response regulator
GXW83_RS19600	COG4585	Histidine kinase
GXW83_RS19645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GXW83_RS19655	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS19660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GXW83_RS19700	COG0420	3'-5' exonuclease activity
GXW83_RS19705	COG0419	ATPase involved in DNA repair
GXW83_RS19710	COG0366	Alpha amylase catalytic
GXW83_RS19715	COG2183	response to ionizing radiation
GXW83_RS19730	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS19735	COG0166	Belongs to the GPI family
GXW83_RS19740	COG4585	Histidine kinase
GXW83_RS19750	COG0513	Belongs to the DEAD box helicase family
GXW83_RS19765	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS19770	COG2267	carboxylic ester hydrolase activity
GXW83_RS19785	COG4106	trans-aconitate 2-methyltransferase activity
GXW83_RS19810	COG3511	phospholipase C
GXW83_RS19835	COG0367	asparagine synthase
GXW83_RS19840	COG4941	Belongs to the sigma-70 factor family
GXW83_RS19845	COG3795	YCII-related domain
GXW83_RS19860	COG2261	transglycosylase associated protein
GXW83_RS19885	COG2326	polyphosphate kinase activity
GXW83_RS19890	COG1486	melibiose metabolic process
GXW83_RS19895	COG4608	Belongs to the ABC transporter superfamily
GXW83_RS19900	COG0444	Belongs to the ABC transporter superfamily
GXW83_RS19935	COG0366	Alpha amylase catalytic
GXW83_RS19940	COG0395	ABC-type sugar transport system, permease component
GXW83_RS19945	COG1175	transmembrane transport
GXW83_RS19980	COG0589	response to stress
GXW83_RS19985	COG0363	glucosamine-6-phosphate deaminase activity
GXW83_RS20005	COG0531	amino acid
GXW83_RS20075	COG0800	Aldolase
GXW83_RS20100	COG1063	alcohol dehydrogenase
GXW83_RS20105	COG0156	8-amino-7-oxononanoate synthase activity
GXW83_RS20110	COG0583	DNA-binding transcription factor activity
GXW83_RS20115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GXW83_RS20120	COG0640	Transcriptional regulator
GXW83_RS20125	COG2188	Transcriptional regulator
GXW83_RS20130	COG2175	clavaminate synthase activity
GXW83_RS20145	COG1556	Lactate utilization protein
GXW83_RS20150	COG1139	Iron-sulfur cluster binding protein
GXW83_RS20155	COG0247	lactate metabolic process
GXW83_RS20170	COG0640	Transcriptional regulator
GXW83_RS20175	COG1316	TRANSCRIPTIONal
GXW83_RS20205	COG2197	response regulator
GXW83_RS20215	COG1222	aaa ATPase
GXW83_RS20290	COG0242	peptide deformylase activity
GXW83_RS20320	COG0681	Belongs to the peptidase S26 family
GXW83_RS20325	COG2890	protein-(glutamine-N5) methyltransferase activity
GXW83_RS20330	COG1366	Belongs to the anti-sigma-factor antagonist family
GXW83_RS20350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GXW83_RS20355	COG0501	Belongs to the peptidase M48B family
GXW83_RS20360	COG0531	amino acid
GXW83_RS20405	COG0671	phosphoesterase, PA-phosphatase related
GXW83_RS20480	COG0640	Transcriptional regulator
GXW83_RS20490	COG5297	Belongs to the glycosyl hydrolase family 6
GXW83_RS20500	COG2208	phosphoserine phosphatase activity
GXW83_RS20510	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS20565	COG1278	Cold shock
GXW83_RS20570	COG1652	LysM domain
GXW83_RS20580	COG1744	ABC transporter substrate-binding protein PnrA-like
GXW83_RS20635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GXW83_RS20695	COG1612	heme a metabolic process
GXW83_RS20705	COG3268	Saccharopine dehydrogenase
GXW83_RS20745	COG3345	alpha-galactosidase
GXW83_RS20755	COG3507	Belongs to the glycosyl hydrolase 43 family
GXW83_RS20760	COG1609	Transcriptional regulator
GXW83_RS20770	COG1278	Cold shock
GXW83_RS20785	COG0514	ATP-dependent DNA helicase (RecQ)
GXW83_RS20805	COG2409	Drug exporters of the RND superfamily
GXW83_RS20815	COG3511	phospholipase C
GXW83_RS20845	COG0515	serine threonine protein kinase
GXW83_RS20850	COG1309	transcriptional regulator
GXW83_RS20870	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS20880	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS20885	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS20890	COG1024	Enoyl-CoA hydratase
GXW83_RS20905	COG0183	Belongs to the thiolase family
GXW83_RS20910	COG2084	Dehydrogenase
GXW83_RS20950	COG1309	transcriptional regulator
GXW83_RS20975	COG1309	transcriptional regulator
GXW83_RS20980	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS20995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXW83_RS21000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GXW83_RS21015	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GXW83_RS21040	COG0375	protein maturation
GXW83_RS21045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GXW83_RS21050	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GXW83_RS21055	COG0298	carbon dioxide binding
GXW83_RS21065	COG0309	Hydrogenase expression formation protein (HypE)
GXW83_RS21100	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS21105	COG3387	PFAM Glycoside hydrolase 15-related
GXW83_RS21130	COG2255	four-way junction helicase activity
GXW83_RS21145	COG1793	dna ligase
GXW83_RS21175	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS21180	COG1012	belongs to the aldehyde dehydrogenase family
GXW83_RS21185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GXW83_RS21195	COG0531	amino acid
GXW83_RS21200	COG3511	phospholipase C
GXW83_RS21205	COG2186	Transcriptional regulator
GXW83_RS21225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GXW83_RS21230	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GXW83_RS21235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GXW83_RS21280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GXW83_RS21285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXW83_RS21290	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GXW83_RS21295	COG0110	maltose O-acetyltransferase activity
GXW83_RS21305	COG0297	glycogen (starch) synthase activity
GXW83_RS21360	COG0411	ABC transporter
GXW83_RS21370	COG3903	Transcriptional regulator
GXW83_RS21370	COG3629	intracellular signal transduction
GXW83_RS21405	COG2205	protein histidine kinase activity
GXW83_RS21445	COG3608	succinylglutamate desuccinylase aspartoacylase
GXW83_RS21445	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GXW83_RS21450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GXW83_RS21480	COG0601	transmembrane transport
GXW83_RS21485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXW83_RS21490	COG0747	negative chemotaxis
GXW83_RS21510	COG0037	tRNA processing
GXW83_RS21540	COG4555	ABC transporter
GXW83_RS21555	COG2814	Major facilitator Superfamily
GXW83_RS21560	COG1309	transcriptional regulator
GXW83_RS21575	COG3903	Transcriptional regulator
GXW83_RS21575	COG3629	intracellular signal transduction
GXW83_RS21585	COG1834	amidinotransferase
GXW83_RS21600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GXW83_RS21610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GXW83_RS21610	COG1522	sequence-specific DNA binding
GXW83_RS21615	COG2313	pseudouridylate synthase activity
GXW83_RS21620	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GXW83_RS21640	COG3831	ATPase activity
GXW83_RS21660	COG1653	transport
GXW83_RS21670	COG1136	(ABC) transporter
GXW83_RS21670	COG0577	efflux transmembrane transporter activity
GXW83_RS21680	COG0366	Alpha amylase catalytic
GXW83_RS21705	COG0454	-acetyltransferase
GXW83_RS21705	COG0456	acetyltransferase
GXW83_RS21730	COG0137	argininosuccinate synthase activity
GXW83_RS21760	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GXW83_RS21770	COG2066	Belongs to the glutaminase family
GXW83_RS21785	COG2197	response regulator
GXW83_RS21820	COG2188	Transcriptional regulator
GXW83_RS21850	COG0464	growth
GXW83_RS21855	COG1674	ftsk spoiiie
GXW83_RS21865	COG3266	domain, Protein
GXW83_RS21915	COG3275	phosphorelay sensor kinase activity
GXW83_RS21920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GXW83_RS21940	COG1846	Transcriptional regulator
GXW83_RS21995	COG2175	clavaminate synthase activity
GXW83_RS22005	COG3251	PFAM MbtH domain protein
GXW83_RS22010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GXW83_RS22030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXW83_RS22035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXW83_RS22040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXW83_RS22075	COG3903	Transcriptional regulator
GXW83_RS22075	COG3629	intracellular signal transduction
GXW83_RS22080	COG3629	intracellular signal transduction
GXW83_RS22110	COG2822	iron ion transport
GXW83_RS22115	COG2837	iron assimilation
GXW83_RS22120	COG3321	synthase
GXW83_RS22120	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS22120	COG0604	alcohol dehydrogenase
GXW83_RS22125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXW83_RS22125	COG3321	synthase
GXW83_RS22130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS22140	COG1819	glycosyl
GXW83_RS22160	COG0326	Molecular chaperone. Has ATPase activity
GXW83_RS22210	COG3629	intracellular signal transduction
GXW83_RS22210	COG3903	Transcriptional regulator
GXW83_RS22370	COG2197	response regulator
GXW83_RS22425	COG0693	protein deglycase activity
GXW83_RS22430	COG0783	Belongs to the Dps family
GXW83_RS22445	COG2208	phosphoserine phosphatase activity
GXW83_RS22445	COG2770	Histidine kinase
GXW83_RS22455	COG1846	Transcriptional regulator
GXW83_RS22465	COG4191	Histidine kinase
GXW83_RS22525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GXW83_RS22530	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS22545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXW83_RS22550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GXW83_RS22555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXW83_RS22560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS22580	COG2267	carboxylic ester hydrolase activity
GXW83_RS22585	COG2815	serine threonine protein kinase
GXW83_RS22585	COG0515	serine threonine protein kinase
GXW83_RS22600	COG1672	PFAM Archaeal ATPase
GXW83_RS22600	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GXW83_RS22625	COG2197	response regulator
GXW83_RS22625	COG3903	Transcriptional regulator
GXW83_RS22640	COG0515	serine threonine protein kinase
GXW83_RS22710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GXW83_RS22740	COG2124	cytochrome p450
GXW83_RS22750	COG2072	flavoprotein involved in K transport
GXW83_RS22765	COG0583	DNA-binding transcription factor activity
GXW83_RS22780	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GXW83_RS22875	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS22895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GXW83_RS22915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXW83_RS22920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GXW83_RS22975	COG2197	response regulator
GXW83_RS22980	COG4585	Histidine kinase
GXW83_RS23020	COG3629	intracellular signal transduction
GXW83_RS23020	COG3903	Transcriptional regulator
GXW83_RS23030	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS23075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXW83_RS23080	COG3321	synthase
GXW83_RS23080	COG0604	alcohol dehydrogenase
GXW83_RS23095	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS23110	COG2345	Transcriptional regulator
GXW83_RS23140	COG0477	Major facilitator Superfamily
GXW83_RS23145	COG0367	asparagine synthase
GXW83_RS23180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXW83_RS23185	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS23205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GXW83_RS23215	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS23240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXW83_RS23240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXW83_RS23260	COG2409	Drug exporters of the RND superfamily
GXW83_RS23265	COG2345	Transcriptional regulator
GXW83_RS23270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXW83_RS23275	COG0475	glutathione-regulated potassium exporter activity
GXW83_RS23315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXW83_RS23320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXW83_RS23395	COG0549	Belongs to the carbamate kinase family
GXW83_RS23400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GXW83_RS23405	COG2235	arginine
GXW83_RS23410	COG0531	amino acid
GXW83_RS23430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GXW83_RS23435	COG0066	3-isopropylmalate dehydratase activity
GXW83_RS23445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GXW83_RS23460	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS23495	COG2226	methyltransferase
GXW83_RS23500	COG2226	methyltransferase
GXW83_RS23525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GXW83_RS23540	COG1619	proteins homologs of microcin C7 resistance protein MccF
GXW83_RS23570	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS23575	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS23595	COG0667	Aldo Keto reductase
GXW83_RS23645	COG0596	Alpha beta hydrolase
GXW83_RS23655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GXW83_RS23665	COG0019	diaminopimelate decarboxylase activity
GXW83_RS23685	COG0300	oxidoreductase activity
GXW83_RS23690	COG3321	synthase
GXW83_RS23695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GXW83_RS23700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS23705	COG1024	Enoyl-CoA hydratase
GXW83_RS23710	COG1024	Enoyl-CoA hydratase
GXW83_RS23715	COG3425	synthase
GXW83_RS23720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GXW83_RS23725	COG2070	2-Nitropropane dioxygenase
GXW83_RS23725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GXW83_RS23730	COG3321	synthase
GXW83_RS23730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS23730	COG0300	oxidoreductase activity
GXW83_RS23730	COG4221	oxidoreductase activity
GXW83_RS23735	COG3321	synthase
GXW83_RS23735	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS23735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXW83_RS23735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS23735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXW83_RS23740	COG0300	oxidoreductase activity
GXW83_RS23740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS23740	COG4221	oxidoreductase activity
GXW83_RS23740	COG3321	synthase
GXW83_RS23745	COG4221	oxidoreductase activity
GXW83_RS23745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS23745	COG3321	synthase
GXW83_RS23745	COG0300	oxidoreductase activity
GXW83_RS23750	COG0300	oxidoreductase activity
GXW83_RS23750	COG3321	synthase
GXW83_RS23750	COG4221	oxidoreductase activity
GXW83_RS23750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS23755	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS23755	COG4221	oxidoreductase activity
GXW83_RS23755	COG3321	synthase
GXW83_RS23755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXW83_RS23760	COG3321	synthase
GXW83_RS23760	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS23760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GXW83_RS23760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXW83_RS23760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GXW83_RS23770	COG2124	cytochrome p450
GXW83_RS23775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GXW83_RS23790	COG0492	ferredoxin-NADP+ reductase activity
GXW83_RS23810	COG1132	(ABC) transporter
GXW83_RS23815	COG1132	(ABC) transporter
GXW83_RS23845	COG1086	Polysaccharide biosynthesis protein
GXW83_RS23870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GXW83_RS23890	COG0019	diaminopimelate decarboxylase activity
GXW83_RS23895	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS23900	COG2226	methyltransferase
GXW83_RS23920	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS23985	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS24005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GXW83_RS24025	COG4585	Histidine kinase
GXW83_RS24030	COG2197	response regulator
GXW83_RS24120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GXW83_RS24140	COG0312	modulator of DNA gyrase
GXW83_RS24175	COG3328	transposase activity
GXW83_RS24215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GXW83_RS24245	COG2197	response regulator
GXW83_RS24250	COG4585	Histidine kinase
GXW83_RS24330	COG0783	Belongs to the Dps family
GXW83_RS24350	COG3835	regulator
GXW83_RS24355	COG0443	Heat shock 70 kDa protein
GXW83_RS24360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GXW83_RS24375	COG0542	response to heat
GXW83_RS24405	COG1396	sequence-specific DNA binding
GXW83_RS24410	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GXW83_RS24415	COG3328	transposase activity
GXW83_RS24460	COG0789	Transcriptional regulator
GXW83_RS24590	COG2801	Transposase and inactivated derivatives
GXW83_RS24655	COG1556	Lactate utilization protein
GXW83_RS24660	COG1139	Iron-sulfur cluster binding protein
GXW83_RS24665	COG0247	lactate metabolic process
GXW83_RS24670	COG1070	Carbohydrate kinase
GXW83_RS24675	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS24675	COG3347	Dehydrogenase
GXW83_RS24680	COG4952	isomerase
GXW83_RS24685	COG1609	Transcriptional regulator
GXW83_RS24710	COG1175	transmembrane transport
GXW83_RS24755	COG0395	ABC-type sugar transport system, permease component
GXW83_RS24760	COG1175	transmembrane transport
GXW83_RS24770	COG3250	beta-galactosidase activity
GXW83_RS24800	COG0300	oxidoreductase activity
GXW83_RS24810	COG0667	Aldo Keto reductase
GXW83_RS24845	COG2801	Transposase and inactivated derivatives
GXW83_RS24875	COG0477	Major facilitator Superfamily
GXW83_RS24880	COG1946	Acyl-CoA thioesterase
GXW83_RS24915	COG0411	ABC transporter
GXW83_RS24925	COG1652	LysM domain
GXW83_RS24940	COG1160	GTP binding
GXW83_RS24945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GXW83_RS24955	COG0697	spore germination
GXW83_RS24960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GXW83_RS24995	COG1187	pseudouridine synthase activity
GXW83_RS25000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GXW83_RS25005	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GXW83_RS25020	COG0686	Belongs to the AlaDH PNT family
GXW83_RS25030	COG0494	nUDIX hydrolase
GXW83_RS25035	COG0504	CTP synthase activity
GXW83_RS25040	COG3387	PFAM Glycoside hydrolase 15-related
GXW83_RS25045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXW83_RS25055	COG0497	DNA recombination
GXW83_RS25060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GXW83_RS25085	COG0647	UMP catabolic process
GXW83_RS25125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GXW83_RS25130	COG2094	Belongs to the DNA glycosylase MPG family
GXW83_RS25135	COG1881	PFAM PEBP family protein
GXW83_RS25150	COG2154	pterin-4-alpha-carbinolamine dehydratase
GXW83_RS25170	COG1119	ATPase activity
GXW83_RS25180	COG2197	response regulator
GXW83_RS25185	COG4585	Histidine kinase
GXW83_RS25195	COG0842	Transport permease protein
GXW83_RS25195	COG1131	(ABC) transporter
GXW83_RS25195	COG1716	ATPase activity
GXW83_RS25205	COG0560	Phosphoserine phosphatase
GXW83_RS25205	COG3830	Belongs to the UPF0237 family
GXW83_RS25215	COG2807	transmembrane transport
GXW83_RS25220	COG2186	Transcriptional regulator
GXW83_RS25225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GXW83_RS25260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GXW83_RS25270	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS25280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GXW83_RS25290	COG3387	PFAM Glycoside hydrolase 15-related
GXW83_RS25315	COG1302	Protein conserved in bacteria
GXW83_RS25320	COG1024	Enoyl-CoA hydratase
GXW83_RS25330	COG0488	(ABC) transporter
GXW83_RS25360	COG0438	transferase activity, transferring glycosyl groups
GXW83_RS25370	COG0728	peptidoglycan biosynthetic process
GXW83_RS25400	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GXW83_RS25405	COG1250	3-hydroxyacyl-CoA dehydrogenase
GXW83_RS25420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXW83_RS25420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXW83_RS25425	COG2301	Belongs to the HpcH HpaI aldolase family
GXW83_RS25435	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS25440	COG0688	phosphatidylethanolamine metabolic process
GXW83_RS25475	COG0174	glutamine synthetase
GXW83_RS25490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXW83_RS25500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GXW83_RS25505	COG1492	cobalamin metabolic process
GXW83_RS25525	COG1797	cobyrinic acid a,c-diamide synthase activity
GXW83_RS25565	COG0463	Glycosyl transferase, family 2
GXW83_RS25610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GXW83_RS25645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXW83_RS25650	COG2310	stress, protein
GXW83_RS25660	COG3422	double-strand break repair
GXW83_RS25710	COG0506	proline dehydrogenase activity
GXW83_RS25715	COG1012	belongs to the aldehyde dehydrogenase family
GXW83_RS25735	COG2151	metal-sulfur cluster biosynthetic enzyme
GXW83_RS25740	COG0822	iron-sulfur transferase activity
GXW83_RS25745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GXW83_RS25750	COG0396	ATPase activity
GXW83_RS25760	COG0719	Fe-S assembly protein
GXW83_RS25805	COG3548	integral membrane protein
GXW83_RS25815	COG0109	protoheme IX farnesyltransferase activity
GXW83_RS25820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GXW83_RS25825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GXW83_RS25840	COG0363	glucosamine-6-phosphate deaminase activity
GXW83_RS25850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GXW83_RS25855	COG0149	triose-phosphate isomerase activity
GXW83_RS25860	COG0126	phosphoglycerate kinase activity
GXW83_RS25865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GXW83_RS25880	COG1660	Displays ATPase and GTPase activities
GXW83_RS25885	COG0322	excinuclease ABC activity
GXW83_RS25900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GXW83_RS25935	COG1278	Cold shock
GXW83_RS25950	COG1278	Cold shock
GXW83_RS25955	COG1278	Cold shock
GXW83_RS25960	COG0477	Major facilitator Superfamily
GXW83_RS25985	COG0556	nucleotide-excision repair
GXW83_RS26005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GXW83_RS26010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GXW83_RS26030	COG0535	radical SAM domain protein
GXW83_RS26065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GXW83_RS26085	COG0183	Belongs to the thiolase family
GXW83_RS26090	COG1024	Enoyl-CoA hydratase
GXW83_RS26090	COG1250	3-hydroxyacyl-CoA dehydrogenase
GXW83_RS26095	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GXW83_RS26115	COG4214	carbohydrate transport
GXW83_RS26130	COG1940	carbohydrate kinase activity
GXW83_RS26150	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GXW83_RS26155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GXW83_RS26210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GXW83_RS26215	COG0531	amino acid
GXW83_RS26220	COG0569	domain protein
GXW83_RS26260	COG0756	dUTP diphosphatase activity
GXW83_RS26290	COG2205	protein histidine kinase activity
GXW83_RS26295	COG0745	RESPONSE REGULATOR receiver
GXW83_RS26355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GXW83_RS26360	COG1012	belongs to the aldehyde dehydrogenase family
GXW83_RS26365	COG3237	CsbD-like
GXW83_RS26370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GXW83_RS26380	COG1846	Transcriptional regulator
GXW83_RS26410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GXW83_RS26445	COG1690	Belongs to the RtcB family
GXW83_RS26465	COG0612	Peptidase, M16
GXW83_RS26470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GXW83_RS26490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GXW83_RS26500	COG2197	response regulator
GXW83_RS26505	COG4585	Histidine kinase
GXW83_RS26515	COG0187	DNA topoisomerase II activity
GXW83_RS26530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GXW83_RS26545	COG1122	ATPase activity
GXW83_RS26550	COG1051	belongs to the nudix hydrolase family
GXW83_RS26550	COG1056	cytidyltransferase-related domain
GXW83_RS26575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GXW83_RS26585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXW83_RS26605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GXW83_RS26615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GXW83_RS26645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GXW83_RS26650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GXW83_RS26655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GXW83_RS26665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GXW83_RS26680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GXW83_RS26725	COG0789	Transcriptional regulator
GXW83_RS26745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GXW83_RS26750	COG2205	protein histidine kinase activity
GXW83_RS26755	COG0745	RESPONSE REGULATOR receiver
GXW83_RS26760	COG1126	abc transporter atp-binding protein
GXW83_RS26775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GXW83_RS26780	COG1418	mRNA catabolic process
GXW83_RS26785	COG2137	regulation of response to DNA damage stimulus
GXW83_RS26790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GXW83_RS26805	COG0477	Major facilitator Superfamily
GXW83_RS26830	COG1396	sequence-specific DNA binding
GXW83_RS26835	COG1546	Belongs to the CinA family
GXW83_RS26835	COG1058	Belongs to the CinA family
GXW83_RS26845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GXW83_RS26855	COG1674	ftsk spoiiie
GXW83_RS26865	COG2205	protein histidine kinase activity
GXW83_RS26865	COG3437	response regulator, receiver
GXW83_RS26865	COG3850	Histidine kinase
GXW83_RS26865	COG4999	Histidine kinase
GXW83_RS26885	COG3135	benzoate transporter
GXW83_RS26905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GXW83_RS26910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GXW83_RS26915	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GXW83_RS26930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GXW83_RS26935	COG0612	Peptidase, M16
GXW83_RS26940	COG1185	polyribonucleotide nucleotidyltransferase activity
GXW83_RS26945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GXW83_RS26955	COG1674	ftsk spoiiie
GXW83_RS26980	COG1404	Belongs to the peptidase S8 family
GXW83_RS27050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GXW83_RS27100	COG3152	Membrane
GXW83_RS27115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GXW83_RS27120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GXW83_RS27125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GXW83_RS27135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GXW83_RS27150	COG0779	Required for maturation of 30S ribosomal subunits
GXW83_RS27160	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GXW83_RS27165	COG4585	Histidine kinase
GXW83_RS27180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GXW83_RS27205	COG1012	belongs to the aldehyde dehydrogenase family
GXW83_RS27220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GXW83_RS27260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GXW83_RS27275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GXW83_RS27285	COG1012	belongs to the aldehyde dehydrogenase family
GXW83_RS27295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GXW83_RS27310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GXW83_RS27315	COG0575	Belongs to the CDS family
GXW83_RS27320	COG0233	cytoplasmic translational termination
GXW83_RS27325	COG0528	UMP kinase activity
GXW83_RS27330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GXW83_RS27335	COG0052	Belongs to the universal ribosomal protein uS2 family
GXW83_RS27350	COG1191	sigma factor activity
GXW83_RS27640	COG0792	nuclease activity
GXW83_RS27650	COG1051	belongs to the nudix hydrolase family
GXW83_RS27665	COG0681	Belongs to the peptidase S26 family
GXW83_RS27675	COG0335	large ribosomal subunit rRNA binding
GXW83_RS27680	COG0336	Belongs to the RNA methyltransferase TrmD family
GXW83_RS27685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GXW83_RS27690	COG1837	Belongs to the UPF0109 family
GXW83_RS27695	COG0228	four-way junction DNA binding
GXW83_RS27705	COG0442	prolyl-tRNA aminoacylation
GXW83_RS27715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GXW83_RS27730	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GXW83_RS27770	COG1254	Belongs to the acylphosphatase family
GXW83_RS27780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GXW83_RS27785	COG0571	ribonuclease III activity
GXW83_RS27790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GXW83_RS27805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GXW83_RS27810	COG0742	ribosomal rna small subunit methyltransferase
GXW83_RS27825	COG1461	Dihydroxyacetone kinase
GXW83_RS27830	COG0351	phosphomethylpyrimidine kinase
GXW83_RS27835	COG0205	6-phosphofructokinase activity
GXW83_RS27860	COG1181	Belongs to the D-alanine--D-alanine ligase family
GXW83_RS27865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GXW83_RS27875	COG1920	GTP binding
GXW83_RS27885	COG0776	regulation of translation
GXW83_RS27890	COG0066	3-isopropylmalate dehydratase activity
GXW83_RS27895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GXW83_RS27900	COG1414	Transcriptional regulator
GXW83_RS27945	COG0179	Fumarylacetoacetate (FAA) hydrolase
GXW83_RS27960	COG2018	Roadblock/LC7 domain
GXW83_RS27980	COG2018	Roadblock/LC7 domain
GXW83_RS27995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GXW83_RS28000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GXW83_RS28005	COG0473	3-isopropylmalate dehydrogenase activity
GXW83_RS28015	COG1605	Chorismate mutase
GXW83_RS28015	COG0287	Prephenate dehydrogenase
GXW83_RS28030	COG1404	Belongs to the peptidase S8 family
GXW83_RS28050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GXW83_RS28055	COG0440	acetolactate synthase activity
GXW83_RS28075	COG1672	PFAM Archaeal ATPase
GXW83_RS28075	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GXW83_RS28090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GXW83_RS28100	COG0154	amidase activity
GXW83_RS28105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GXW83_RS28115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GXW83_RS28125	COG4221	oxidoreductase activity
GXW83_RS28140	COG0482	sulfurtransferase activity
GXW83_RS28150	COG1414	Transcriptional regulator
GXW83_RS28155	COG2860	membrane
GXW83_RS28165	COG4166	transmembrane transport
GXW83_RS28180	COG4608	Belongs to the ABC transporter superfamily
GXW83_RS28195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GXW83_RS28200	COG0509	glycine decarboxylation via glycine cleavage system
GXW83_RS28205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GXW83_RS28210	COG1760	l-serine dehydratase
GXW83_RS28320	COG0714	Associated with various cellular activities
GXW83_RS28365	COG0305	Participates in initiation and elongation during chromosome replication
GXW83_RS28510	COG2124	cytochrome p450
GXW83_RS28515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GXW83_RS28520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GXW83_RS28555	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GXW83_RS28565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXW83_RS28595	COG1011	Hydrolase
GXW83_RS28620	COG0515	serine threonine protein kinase
GXW83_RS28655	COG2226	methyltransferase
GXW83_RS28660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GXW83_RS28670	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GXW83_RS28680	COG0720	synthase
GXW83_RS28685	COG0302	gtp cyclohydrolase
GXW83_RS28695	COG0179	Fumarylacetoacetate (FAA) hydrolase
GXW83_RS28700	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GXW83_RS28705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GXW83_RS28710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GXW83_RS28715	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GXW83_RS28725	COG4865	methylaspartate mutase activity
GXW83_RS28750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GXW83_RS28800	COG1595	DNA-templated transcription, initiation
GXW83_RS28815	COG1132	(ABC) transporter
GXW83_RS28820	COG1132	(ABC) transporter
GXW83_RS28845	COG0058	SHG alpha-glucan phosphorylase activity
GXW83_RS28850	COG0366	Alpha amylase catalytic
GXW83_RS28860	COG3281	Trehalose synthase
GXW83_RS28865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GXW83_RS28870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GXW83_RS28890	COG0280	phosphate acetyltransferase
GXW83_RS28890	COG0857	belongs to the CobB CobQ family
GXW83_RS28895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GXW83_RS28930	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXW83_RS28930	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXW83_RS28965	COG0183	Belongs to the thiolase family
GXW83_RS28985	COG2267	carboxylic ester hydrolase activity
GXW83_RS29015	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GXW83_RS29030	COG1250	3-hydroxyacyl-CoA dehydrogenase
GXW83_RS29040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GXW83_RS29055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GXW83_RS29060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GXW83_RS29065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GXW83_RS29070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GXW83_RS29075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GXW83_RS29080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GXW83_RS29085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GXW83_RS29100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GXW83_RS29110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GXW83_RS29120	COG2890	protein-(glutamine-N5) methyltransferase activity
GXW83_RS29125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GXW83_RS29130	COG0254	rRNA binding
GXW83_RS29145	COG0083	homoserine kinase activity
GXW83_RS29150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GXW83_RS29160	COG0019	diaminopimelate decarboxylase activity
GXW83_RS29165	COG0018	arginyl-trna synthetase
GXW83_RS29170	COG0745	RESPONSE REGULATOR receiver
GXW83_RS29230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GXW83_RS29240	COG1011	Hydrolase
GXW83_RS29275	COG1070	Carbohydrate kinase
GXW83_RS29305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GXW83_RS29310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GXW83_RS29320	COG0745	RESPONSE REGULATOR receiver
GXW83_RS29325	COG2205	protein histidine kinase activity
GXW83_RS29330	COG0567	Dehydrogenase, E1 component
GXW83_RS29330	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXW83_RS29355	COG0604	alcohol dehydrogenase
GXW83_RS29360	COG0281	malic enzyme
GXW83_RS29410	COG1597	lipid kinase activity
GXW83_RS29430	COG2182	Extracellular solute-binding protein
GXW83_RS29435	COG1472	Belongs to the glycosyl hydrolase 3 family
GXW83_RS29440	COG0395	ABC-type sugar transport system, permease component
GXW83_RS29445	COG1175	transmembrane transport
GXW83_RS29450	COG2182	Extracellular solute-binding protein
GXW83_RS29455	COG2188	Transcriptional regulator
GXW83_RS29475	COG1012	belongs to the aldehyde dehydrogenase family
GXW83_RS29480	COG1012	belongs to the aldehyde dehydrogenase family
GXW83_RS29490	COG0745	RESPONSE REGULATOR receiver
GXW83_RS29495	COG2205	protein histidine kinase activity
GXW83_RS29520	COG0583	DNA-binding transcription factor activity
GXW83_RS29525	COG2814	Major facilitator Superfamily
GXW83_RS29540	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GXW83_RS29540	COG1473	amidohydrolase
GXW83_RS29555	COG2009	succinate dehydrogenase
GXW83_RS29570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GXW83_RS29580	COG1686	Belongs to the peptidase S11 family
GXW83_RS29600	COG0745	RESPONSE REGULATOR receiver
GXW83_RS29610	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GXW83_RS29620	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GXW83_RS29635	COG0180	Tryptophanyl-tRNA synthetase
GXW83_RS29640	COG1253	flavin adenine dinucleotide binding
GXW83_RS29645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GXW83_RS29650	COG0039	L-malate dehydrogenase activity
GXW83_RS29670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GXW83_RS29680	COG1714	RDD family
GXW83_RS29685	COG0138	bifunctional purine biosynthesis protein purh
GXW83_RS29715	COG0045	succinate-CoA ligase (ADP-forming) activity
GXW83_RS29725	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GXW83_RS29735	COG0714	Associated with various cellular activities
GXW83_RS29750	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXW83_RS29750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GXW83_RS29765	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GXW83_RS29770	COG0791	NLP P60 protein
GXW83_RS29775	COG2197	response regulator
GXW83_RS29805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GXW83_RS29805	COG0519	Catalyzes the synthesis of GMP from XMP
GXW83_RS29820	COG1012	belongs to the aldehyde dehydrogenase family
GXW83_RS29850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GXW83_RS29860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GXW83_RS29865	COG2815	serine threonine protein kinase
GXW83_RS29865	COG0515	serine threonine protein kinase
GXW83_RS29875	COG2815	serine threonine protein kinase
GXW83_RS29875	COG0515	serine threonine protein kinase
GXW83_RS29880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GXW83_RS29890	COG0516	GMP reductase activity
GXW83_RS29900	COG1595	DNA-templated transcription, initiation
GXW83_RS29905	COG2197	response regulator
GXW83_RS29915	COG0583	DNA-binding transcription factor activity
GXW83_RS29930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GXW83_RS29940	COG0726	polysaccharide deacetylase
GXW83_RS29945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GXW83_RS29970	COG0802	atpase or kinase
GXW83_RS29980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GXW83_RS29990	COG0736	holo-[acyl-carrier-protein] synthase activity
GXW83_RS30010	COG1072	(Pantothenic acid kinase))
GXW83_RS30020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GXW83_RS30025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GXW83_RS30030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GXW83_RS30035	COG0488	(ABC) transporter
GXW83_RS30045	COG0101	tRNA pseudouridine synthase activity
GXW83_RS30050	COG0203	ribosomal protein L17
GXW83_RS30055	COG0202	RNA polymerase activity
GXW83_RS30060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GXW83_RS30065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GXW83_RS30070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GXW83_RS30075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GXW83_RS30085	COG0563	adenylate kinase activity
GXW83_RS30095	COG0200	Binds to the 23S rRNA
GXW83_RS30105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GXW83_RS30110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GXW83_RS30115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GXW83_RS30120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GXW83_RS30125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GXW83_RS30130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GXW83_RS30135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GXW83_RS30140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GXW83_RS30145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GXW83_RS30150	COG0255	Belongs to the universal ribosomal protein uL29 family
GXW83_RS30155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GXW83_RS30160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GXW83_RS30165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GXW83_RS30170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GXW83_RS30175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GXW83_RS30185	COG0088	Forms part of the polypeptide exit tunnel
GXW83_RS30190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GXW83_RS30195	COG0051	transcription antitermination factor activity, RNA binding
GXW83_RS30220	COG1215	transferase activity, transferring glycosyl groups
GXW83_RS30250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GXW83_RS30255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GXW83_RS30260	COG0049	tRNA binding
GXW83_RS30265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GXW83_RS30285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GXW83_RS30290	COG0085	RNA polymerase activity
GXW83_RS30295	COG0222	ribosome binding
GXW83_RS30300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GXW83_RS30310	COG0081	regulation of translation
GXW83_RS30315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GXW83_RS30320	COG0250	Participates in transcription elongation, termination and antitermination
GXW83_RS30335	COG0436	Aminotransferase
GXW83_RS30340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GXW83_RS30345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GXW83_RS30365	COG2030	dehydratase
GXW83_RS30370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GXW83_RS30410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GXW83_RS30415	COG0601	transmembrane transport
GXW83_RS30430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GXW83_RS30460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GXW83_RS30470	COG1666	GTP binding
GXW83_RS30475	COG0242	peptide deformylase activity
GXW83_RS30495	COG0501	Belongs to the peptidase M48B family
GXW83_RS30500	COG1007	ATP synthesis coupled electron transport
GXW83_RS30510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GXW83_RS30515	COG0713	ATP synthesis coupled electron transport
GXW83_RS30520	COG0839	Belongs to the complex I subunit 6 family
GXW83_RS30525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXW83_RS30535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXW83_RS30540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GXW83_RS30580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXW83_RS30625	COG2188	Transcriptional regulator
GXW83_RS30630	COG4585	Histidine kinase
GXW83_RS30635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GXW83_RS30640	COG0193	aminoacyl-tRNA hydrolase activity
GXW83_RS30645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GXW83_RS30650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GXW83_RS30655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GXW83_RS30685	COG4106	trans-aconitate 2-methyltransferase activity
GXW83_RS30690	COG1846	Transcriptional regulator
GXW83_RS30700	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GXW83_RS30700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GXW83_RS30710	COG2197	response regulator
GXW83_RS30720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GXW83_RS30750	COG0477	Major facilitator Superfamily
GXW83_RS30770	COG0488	(ABC) transporter
GXW83_RS30775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GXW83_RS30780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GXW83_RS30790	COG0084	hydrolase, TatD family'
GXW83_RS30795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GXW83_RS30815	COG2514	catechol 2,3-dioxygenase activity
GXW83_RS30825	COG2197	response regulator
GXW83_RS30830	COG4585	Histidine kinase
GXW83_RS30835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GXW83_RS30845	COG0772	Belongs to the SEDS family
GXW83_RS30860	COG0745	RESPONSE REGULATOR receiver
GXW83_RS30915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GXW83_RS30920	COG0521	Mo-molybdopterin cofactor biosynthetic process
GXW83_RS30925	COG0315	cyclic pyranopterin monophosphate synthase activity
GXW83_RS30935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GXW83_RS30945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GXW83_RS30975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GXW83_RS30985	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS31010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GXW83_RS31015	COG1309	transcriptional regulator
GXW83_RS31025	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS31035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GXW83_RS31060	COG0045	succinate-CoA ligase (ADP-forming) activity
GXW83_RS31065	COG1024	Enoyl-CoA hydratase
GXW83_RS31075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GXW83_RS31105	COG2252	PERMEase
GXW83_RS31115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GXW83_RS31155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GXW83_RS31160	COG1333	cytochrome c biogenesis protein
GXW83_RS31165	COG0785	Cytochrome C biogenesis protein
GXW83_RS31170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GXW83_RS31175	COG0406	alpha-ribazole phosphatase activity
GXW83_RS31180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GXW83_RS31225	COG1309	transcriptional regulator
GXW83_RS31300	COG0113	porphobilinogen synthase activity
GXW83_RS31305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GXW83_RS31305	COG1648	precorrin-2 dehydrogenase activity
GXW83_RS31310	COG0181	hydroxymethylbilane synthase activity
GXW83_RS31315	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GXW83_RS31360	COG0123	including yeast histone deacetylase and acetoin utilization protein
GXW83_RS31375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GXW83_RS31380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GXW83_RS31395	COG0129	dihydroxy-acid dehydratase activity
GXW83_RS31400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GXW83_RS31405	COG1082	Xylose isomerase domain protein TIM barrel
GXW83_RS31410	COG0248	Ppx GppA phosphatase
GXW83_RS31420	COG5398	heme oxygenase
GXW83_RS31440	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GXW83_RS31455	COG1309	transcriptional regulator
GXW83_RS31480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GXW83_RS31510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GXW83_RS31515	COG0157	Belongs to the NadC ModD family
GXW83_RS31520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GXW83_RS31525	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GXW83_RS31530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GXW83_RS31535	COG0204	Acyl-transferase
GXW83_RS31535	COG0318	PFAM AMP-dependent synthetase and ligase
GXW83_RS31545	COG2197	response regulator
GXW83_RS31550	COG4585	Histidine kinase
GXW83_RS31560	COG0649	NAD binding
GXW83_RS31570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GXW83_RS31580	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS31595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXW83_RS31605	COG0640	Transcriptional regulator
GXW83_RS31635	COG4762	Protein conserved in bacteria
GXW83_RS31640	COG2197	response regulator
GXW83_RS31655	COG1316	TRANSCRIPTIONal
GXW83_RS31670	COG1472	Belongs to the glycosyl hydrolase 3 family
GXW83_RS31705	COG3842	ATPase activity
GXW83_RS31715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GXW83_RS31730	COG0215	cysteine-tRNA ligase activity
GXW83_RS31735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GXW83_RS31740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GXW83_RS31745	COG1329	Transcriptional regulator
GXW83_RS31755	COG0745	RESPONSE REGULATOR receiver
GXW83_RS31760	COG5002	protein histidine kinase activity
GXW83_RS31775	COG0588	phosphoglycerate mutase activity
GXW83_RS31785	COG4552	Acetyltransferase involved in intracellular survival and related
GXW83_RS31790	COG1309	transcriptional regulator
GXW83_RS31805	COG2318	DinB family
GXW83_RS31815	COG0154	amidase activity
GXW83_RS31820	COG2226	methyltransferase
GXW83_RS31825	COG0446	pyridine nucleotide-disulphide oxidoreductase
GXW83_RS31890	COG0438	transferase activity, transferring glycosyl groups
GXW83_RS31910	COG1490	D-aminoacyl-tRNA deacylase activity
GXW83_RS31915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GXW83_RS31925	COG3485	protocatechuate 3,4-dioxygenase
GXW83_RS31940	COG2897	thiosulfate sulfurtransferase activity
GXW83_RS31965	COG0745	RESPONSE REGULATOR receiver
GXW83_RS31970	COG1609	Transcriptional regulator
GXW83_RS31975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GXW83_RS31995	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GXW83_RS32000	COG0456	acetyltransferase
GXW83_RS32040	COG0306	phosphate transporter
GXW83_RS32050	COG1937	Protein conserved in bacteria
GXW83_RS32070	COG0277	FAD linked oxidase domain protein
GXW83_RS32075	COG0671	phosphoesterase, PA-phosphatase related
GXW83_RS32185	COG0579	oxidoreductase
GXW83_RS32190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GXW83_RS32225	COG1968	undecaprenyl-diphosphatase activity
GXW83_RS32245	COG5002	protein histidine kinase activity
GXW83_RS32250	COG2018	Roadblock/LC7 domain
GXW83_RS32265	COG1174	glycine betaine transport
GXW83_RS32270	COG1174	glycine betaine transport
GXW83_RS32280	COG1316	TRANSCRIPTIONal
GXW83_RS32310	COG1595	DNA-templated transcription, initiation
GXW83_RS32425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GXW83_RS32435	COG0513	Belongs to the DEAD box helicase family
GXW83_RS32490	COG2855	membrane
GXW83_RS32520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GXW83_RS32525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GXW83_RS32550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GXW83_RS32560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GXW83_RS32585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GXW83_RS32590	COG0047	phosphoribosylformylglycinamidine synthase activity
GXW83_RS32595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GXW83_RS32615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GXW83_RS32630	COG0151	Belongs to the GarS family
GXW83_RS32645	COG1802	Transcriptional regulator
GXW83_RS32665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GXW83_RS32680	COG0191	fructose-bisphosphate aldolase activity
GXW83_RS32685	COG0586	Pfam SNARE associated Golgi protein
GXW83_RS32690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GXW83_RS32705	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GXW83_RS32725	COG1121	(ABC) transporter
GXW83_RS32755	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
GXW83_RS32775	COG0525	valine-tRNA ligase activity
GXW83_RS32790	COG0542	response to heat
GXW83_RS32800	COG2318	DinB family
GXW83_RS32825	COG1362	aminopeptidase activity
GXW83_RS32830	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS32865	COG1960	acyl-CoA dehydrogenase activity
GXW83_RS32895	COG1316	TRANSCRIPTIONal
GXW83_RS32930	COG1595	DNA-templated transcription, initiation
GXW83_RS32940	COG0604	alcohol dehydrogenase
GXW83_RS32940	COG3321	synthase
GXW83_RS32940	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS32960	COG0515	serine threonine protein kinase
GXW83_RS32965	COG0515	serine threonine protein kinase
GXW83_RS32980	COG0022	dehydrogenase e1 component
GXW83_RS32985	COG0508	dehydrogenase complex catalyzes the overall conversion of
GXW83_RS33015	COG1461	Dihydroxyacetone kinase
GXW83_RS33020	COG2376	Dihydroxyacetone kinase
GXW83_RS33025	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GXW83_RS33040	COG0789	Transcriptional regulator
GXW83_RS33045	COG0484	heat shock protein binding
GXW83_RS33050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GXW83_RS33055	COG0443	Heat shock 70 kDa protein
GXW83_RS33060	COG0247	lactate metabolic process
GXW83_RS33060	COG2181	nitrate reductase activity
GXW83_RS33075	COG0717	Belongs to the dCTP deaminase family
GXW83_RS33160	COG1396	sequence-specific DNA binding
GXW83_RS33160	COG3800	Transcriptional regulator
GXW83_RS33180	COG1397	ADP-ribosylglycohydrolase
GXW83_RS33205	COG2188	Transcriptional regulator
GXW83_RS33245	COG2378	regulation of single-species biofilm formation
GXW83_RS33255	COG1846	Transcriptional regulator
GXW83_RS33260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXW83_RS33270	COG1902	pentaerythritol trinitrate reductase activity
GXW83_RS33275	COG3328	transposase activity
GXW83_RS33280	COG0513	Belongs to the DEAD box helicase family
GXW83_RS33285	COG1278	Cold shock
GXW83_RS33310	COG1335	isochorismatase
GXW83_RS33320	COG3046	protein related to deoxyribodipyrimidine photolyase
GXW83_RS33340	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS33370	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GXW83_RS33400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GXW83_RS33410	COG3903	Transcriptional regulator
GXW83_RS33410	COG3629	intracellular signal transduction
GXW83_RS33425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GXW83_RS33440	COG0604	alcohol dehydrogenase
GXW83_RS33440	COG3321	synthase
GXW83_RS33440	COG1028	Short-chain dehydrogenase reductase Sdr
GXW83_RS33450	COG0305	Participates in initiation and elongation during chromosome replication
GXW83_RS33455	COG0534	Mate efflux family protein
GXW83_RS33465	COG0359	binds to the 23S rRNA
GXW83_RS33470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GXW83_RS33475	COG0629	single-stranded DNA binding
GXW83_RS33480	COG0360	Binds together with S18 to 16S ribosomal RNA
GXW83_RS33505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GXW83_RS33515	COG1260	myo-inositol-1-phosphate synthase
GXW83_RS33525	COG0617	tRNA 3'-terminal CCA addition
GXW83_RS33540	COG2815	serine threonine protein kinase
GXW83_RS33540	COG0515	serine threonine protein kinase
GXW83_RS33545	COG1595	DNA-templated transcription, initiation
GXW83_RS33560	COG3118	belongs to the thioredoxin family
GXW83_RS33565	COG0860	N-Acetylmuramoyl-L-alanine amidase
GXW83_RS33565	COG3409	Peptidoglycan-binding domain 1 protein
GXW83_RS33585	COG0357	Ribosomal RNA small subunit methyltransferase G
GXW83_RS33595	COG0706	membrane insertase activity
GXW83_RS33600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GXW83_RS33610	COG0230	Belongs to the bacterial ribosomal protein bL34 family