locus-tag	class	description
DX05_RS00010	COG0592	DNA-directed DNA polymerase activity
DX05_RS00035	COG0012	GTP binding
DX05_RS00045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DX05_RS00050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DX05_RS00080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DX05_RS00265	COG0436	Aminotransferase
DX05_RS00285	COG0416	fatty acid biosynthetic process
DX05_RS00290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DX05_RS00295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DX05_RS00300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DX05_RS00315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DX05_RS00320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DX05_RS00330	COG0138	bifunctional purine biosynthesis protein purh
DX05_RS00355	COG1175	transmembrane transport
DX05_RS00360	COG0395	ABC-type sugar transport system, permease component
DX05_RS00375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DX05_RS00385	COG3458	cephalosporin-C deacetylase activity
DX05_RS00400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DX05_RS00430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DX05_RS00445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DX05_RS00455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DX05_RS00455	COG2755	lipolytic protein G-D-S-L family
DX05_RS00460	COG1454	alcohol dehydrogenase
DX05_RS00460	COG1012	belongs to the aldehyde dehydrogenase family
DX05_RS00465	COG1064	alcohol dehydrogenase
DX05_RS00475	COG0534	Mate efflux family protein
DX05_RS00585	COG0201	protein transport
DX05_RS00590	COG0563	adenylate kinase activity
DX05_RS00600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DX05_RS00610	COG0202	RNA polymerase activity
DX05_RS00735	COG3344	reverse transcriptase
DX05_RS00755	COG1705	Flagellar rod assembly protein muramidase FlgJ
DX05_RS00770	COG0443	Heat shock 70 kDa protein
DX05_RS00780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DX05_RS00785	COG0101	tRNA pseudouridine synthase activity
DX05_RS00790	COG0351	phosphomethylpyrimidine kinase
DX05_RS00795	COG4720	Psort location CytoplasmicMembrane, score
DX05_RS00810	COG0668	transmembrane transport
DX05_RS00840	COG0756	dUTP diphosphatase activity
DX05_RS00855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DX05_RS00860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DX05_RS00865	COG1879	ABC-type sugar transport system periplasmic component
DX05_RS00870	COG1172	Belongs to the binding-protein-dependent transport system permease family
DX05_RS00885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DX05_RS00890	COG1609	Transcriptional regulator
DX05_RS00895	COG0577	efflux transmembrane transporter activity
DX05_RS00900	COG1136	(ABC) transporter
DX05_RS00905	COG0745	RESPONSE REGULATOR receiver
DX05_RS00910	COG5002	protein histidine kinase activity
DX05_RS00925	COG0191	fructose-bisphosphate aldolase activity
DX05_RS00945	COG1461	Dihydroxyacetone kinase
DX05_RS00965	COG1126	abc transporter atp-binding protein
DX05_RS00970	COG0765	amino acid transport
DX05_RS00990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DX05_RS00995	COG3344	reverse transcriptase
DX05_RS01010	COG0719	Fe-S assembly protein
DX05_RS01015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DX05_RS01025	COG0719	Fe-S assembly protein
DX05_RS01030	COG1686	Belongs to the peptidase S11 family
DX05_RS01035	COG1686	Belongs to the peptidase S11 family
DX05_RS01040	COG4166	transmembrane transport
DX05_RS01045	COG0601	transmembrane transport
DX05_RS01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DX05_RS01055	COG0444	Belongs to the ABC transporter superfamily
DX05_RS01060	COG4608	Belongs to the ABC transporter superfamily
DX05_RS01100	COG1121	(ABC) transporter
DX05_RS01105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DX05_RS01215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DX05_RS01220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DX05_RS01220	COG4499	WXG100 protein secretion system (Wss), protein YukC
DX05_RS01240	COG3344	reverse transcriptase
DX05_RS01250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DX05_RS01260	COG2801	Transposase and inactivated derivatives
DX05_RS01300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DX05_RS01305	COG1363	Peptidase, m42
DX05_RS01320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DX05_RS01325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DX05_RS01340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DX05_RS01360	COG1346	cytolysis
DX05_RS01370	COG0601	transmembrane transport
DX05_RS01375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DX05_RS01380	COG1122	ATPase activity
DX05_RS01390	COG1263	PTS System
DX05_RS01390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DX05_RS01395	COG0366	Alpha amylase catalytic
DX05_RS01400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DX05_RS01415	COG3959	Transketolase, thiamine diphosphate binding domain
DX05_RS01420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DX05_RS01425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DX05_RS01445	COG1045	serine acetyltransferase
DX05_RS01455	COG0215	cysteine-tRNA ligase activity
DX05_RS01460	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DX05_RS01485	COG1476	TRANSCRIPTIONal
DX05_RS01490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DX05_RS01500	COG4974	Belongs to the 'phage' integrase family
DX05_RS01605	COG1396	sequence-specific DNA binding
DX05_RS01610	COG2814	Major facilitator Superfamily
DX05_RS01620	COG1732	Glycine betaine
DX05_RS01720	COG0519	Catalyzes the synthesis of GMP from XMP
DX05_RS01765	COG1695	Transcriptional regulator
DX05_RS01780	COG1755	Isoprenylcysteine carboxyl methyltransferase
DX05_RS01820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DX05_RS01825	COG0446	pyridine nucleotide-disulphide oxidoreductase
DX05_RS01845	COG1131	(ABC) transporter
DX05_RS01855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DX05_RS01855	COG1263	PTS System
DX05_RS01855	COG2190	(PTS) system
DX05_RS01860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DX05_RS01865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DX05_RS01870	COG0275	rRNA processing
DX05_RS01880	COG0768	penicillin binding
DX05_RS01890	COG0513	Belongs to the DEAD box helicase family
DX05_RS01905	COG1126	abc transporter atp-binding protein
DX05_RS01915	COG0492	ferredoxin-NADP+ reductase activity
DX05_RS01920	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DX05_RS01935	COG3579	cysteine-type endopeptidase activity
DX05_RS01940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DX05_RS01960	COG0116	Belongs to the methyltransferase superfamily
DX05_RS01970	COG1854	S-ribosylhomocysteine lyase activity
DX05_RS01975	COG4372	Transposase
DX05_RS01975	COG1418	mRNA catabolic process
DX05_RS01980	COG1131	(ABC) transporter
DX05_RS01995	COG2197	response regulator
DX05_RS02005	COG0194	GDP metabolic process
DX05_RS02015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DX05_RS02020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DX05_RS02025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DX05_RS02025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DX05_RS02035	COG0515	serine threonine protein kinase
DX05_RS02035	COG2815	serine threonine protein kinase
DX05_RS02045	COG4585	Histidine kinase
DX05_RS02050	COG2197	response regulator
DX05_RS02060	COG1098	S1 RNA binding domain
DX05_RS02065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DX05_RS02070	COG1349	DNA-binding transcription factor activity
DX05_RS02080	COG1447	Phosphotransferase system cellobiose-specific component IIA
DX05_RS02090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DX05_RS02095	COG1882	Formate acetyltransferase
DX05_RS02115	COG1739	Uncharacterized protein family UPF0029
DX05_RS02120	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DX05_RS02125	COG1040	competence protein
DX05_RS02160	COG0527	aspartate kinase activity
DX05_RS02165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DX05_RS02170	COG1024	Enoyl-CoA hydratase
DX05_RS02180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DX05_RS02190	COG2070	2-Nitropropane dioxygenase
DX05_RS02195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DX05_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
DX05_RS02205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DX05_RS02220	COG0439	Biotin carboxylase
DX05_RS02240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DX05_RS02260	COG3716	PTS system mannose fructose sorbose family IID component
DX05_RS02265	COG3715	PTS system
DX05_RS02275	COG0561	phosphatase activity
DX05_RS02290	COG2252	PERMEase
DX05_RS02295	COG0802	atpase or kinase
DX05_RS02305	COG1316	TRANSCRIPTIONal
DX05_RS02315	COG0537	adenosine 5'-monophosphoramidase activity
DX05_RS02330	COG1131	(ABC) transporter
DX05_RS02335	COG4473	ABC transporter
DX05_RS02345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DX05_RS02360	COG0195	Participates in both transcription termination and antitermination
DX05_RS02365	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DX05_RS02375	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DX05_RS02380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DX05_RS02405	COG2860	membrane
DX05_RS02415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DX05_RS02415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DX05_RS02420	COG1832	CoA-binding protein
DX05_RS02430	COG3344	reverse transcriptase
DX05_RS02445	COG5002	protein histidine kinase activity
DX05_RS02465	COG1268	BioY protein
DX05_RS02470	COG1234	tRNA 3'-trailer cleavage
DX05_RS02485	COG0166	Belongs to the GPI family
DX05_RS02490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DX05_RS02495	COG0705	Rhomboid family
DX05_RS02495	COG0457	Tetratricopeptide repeat
DX05_RS02500	COG1744	ABC transporter substrate-binding protein PnrA-like
DX05_RS02515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DX05_RS02530	COG0706	membrane insertase activity
DX05_RS02600	COG2137	regulation of response to DNA damage stimulus
DX05_RS02605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DX05_RS02615	COG2153	protein acetylation
DX05_RS02625	COG1442	glycosyl transferase family 8
DX05_RS02625	COG1216	Glycosyl transferase, family 2
DX05_RS02660	COG2801	Transposase and inactivated derivatives
DX05_RS02670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DX05_RS02680	COG0789	Transcriptional regulator
DX05_RS02690	COG0656	L-ascorbic acid biosynthetic process
DX05_RS02745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DX05_RS02760	COG0673	inositol 2-dehydrogenase activity
DX05_RS02770	COG2315	Protein conserved in bacteria
DX05_RS02785	COG0742	ribosomal rna small subunit methyltransferase
DX05_RS02800	COG3480	Lon protease (S16) C-terminal proteolytic domain
DX05_RS02805	COG0737	Belongs to the 5'-nucleotidase family
DX05_RS02810	COG4470	Protein conserved in bacteria
DX05_RS02815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DX05_RS02825	COG5433	transposase activity
DX05_RS02830	COG1132	(ABC) transporter
DX05_RS02835	COG1132	(ABC) transporter
DX05_RS02840	COG0512	Glutamine amidotransferase of anthranilate synthase
DX05_RS02845	COG1268	BioY protein
DX05_RS02850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DX05_RS02870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DX05_RS02885	COG1940	carbohydrate kinase activity
DX05_RS02890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DX05_RS02895	COG1217	gtp-binding protein TYPA
DX05_RS02905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DX05_RS02930	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DX05_RS02940	COG0762	integral membrane protein
DX05_RS02945	COG2302	S4 RNA-binding domain
DX05_RS02950	COG3599	regulation of cell shape
DX05_RS02955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DX05_RS02965	COG0494	nUDIX hydrolase
DX05_RS02970	COG0542	response to heat
DX05_RS02975	COG4703	Protein of unknown function (DUF1797)
DX05_RS02980	COG0765	amino acid transport
DX05_RS02985	COG1126	abc transporter atp-binding protein
DX05_RS02990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DX05_RS03000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DX05_RS03005	COG1570	exodeoxyribonuclease VII activity
DX05_RS03010	COG1722	exodeoxyribonuclease VII activity
DX05_RS03020	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DX05_RS03025	COG1438	arginine binding
DX05_RS03030	COG0497	DNA recombination
DX05_RS03035	COG1307	EDD domain protein, DegV family
DX05_RS03040	COG2755	lipolytic protein G-D-S-L family
DX05_RS03060	COG2801	Transposase and inactivated derivatives
DX05_RS03095	COG1078	dGTPase activity
DX05_RS03120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DX05_RS03130	COG2884	Cell division ATP-binding protein ftsE
DX05_RS03135	COG2177	Part of the ABC transporter FtsEX involved in
DX05_RS03160	COG3344	reverse transcriptase
DX05_RS03165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DX05_RS03165	COG1199	ATP-dependent helicase activity
DX05_RS03170	COG0436	Aminotransferase
DX05_RS03175	COG0017	Asparaginyl-tRNA synthetase
DX05_RS03195	COG1660	Displays ATPase and GTPase activities
DX05_RS03225	COG0254	rRNA binding
DX05_RS03230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DX05_RS03235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DX05_RS03240	COG0716	FMN binding
DX05_RS03245	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DX05_RS03245	COG1605	Chorismate mutase
DX05_RS03250	COG0038	chloride channel
DX05_RS03255	COG0335	large ribosomal subunit rRNA binding
DX05_RS03265	COG0582	viral genome integration into host DNA
DX05_RS03580	COG1136	(ABC) transporter
DX05_RS03595	COG5002	protein histidine kinase activity
DX05_RS03610	COG3344	reverse transcriptase
DX05_RS03620	COG0772	Belongs to the SEDS family
DX05_RS03625	COG5433	transposase activity
DX05_RS03645	COG0560	Phosphoserine phosphatase
DX05_RS03660	COG0148	phosphopyruvate hydratase activity
DX05_RS03680	COG1316	TRANSCRIPTIONal
DX05_RS03755	COG0551	DNA topoisomerase type I activity
DX05_RS03755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DX05_RS03775	COG0745	RESPONSE REGULATOR receiver
DX05_RS03785	COG0577	efflux transmembrane transporter activity
DX05_RS03785	COG1136	(ABC) transporter
DX05_RS03860	COG4581	dead DEAH box helicase
DX05_RS03875	COG1309	transcriptional regulator
DX05_RS03880	COG2375	cellular response to nickel ion
DX05_RS03880	COG1132	(ABC) transporter
DX05_RS03885	COG1132	(ABC) transporter
DX05_RS03900	COG1129	ABC transporter
DX05_RS03905	COG0534	Mate efflux family protein
DX05_RS03940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DX05_RS03945	COG4555	ABC transporter
DX05_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
DX05_RS03975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DX05_RS03980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DX05_RS04000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DX05_RS04005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DX05_RS04035	COG1136	(ABC) transporter
DX05_RS04050	COG0586	Pfam SNARE associated Golgi protein
DX05_RS04055	COG4619	ABC transporter
DX05_RS04060	COG0390	transport system, permease component
DX05_RS04070	COG0583	DNA-binding transcription factor activity
DX05_RS04085	COG2211	Major facilitator Superfamily
DX05_RS04095	COG3250	beta-galactosidase activity
DX05_RS04100	COG2186	Transcriptional regulator
DX05_RS04105	COG0800	Aldolase
DX05_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
DX05_RS04135	COG3344	reverse transcriptase
DX05_RS04150	COG1609	Transcriptional regulator
DX05_RS04165	COG0438	transferase activity, transferring glycosyl groups
DX05_RS04195	COG0765	amino acid transport
DX05_RS04200	COG0765	amino acid transport
DX05_RS04205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DX05_RS04210	COG1126	abc transporter atp-binding protein
DX05_RS04215	COG0745	RESPONSE REGULATOR receiver
DX05_RS04220	COG5002	protein histidine kinase activity
DX05_RS04225	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DX05_RS04230	COG2832	Protein of unknown function (DUF454)
DX05_RS04240	COG1196	nuclear chromosome segregation
DX05_RS04245	COG5433	transposase activity
DX05_RS04250	COG0561	phosphatase activity
DX05_RS04255	COG0561	phosphatase activity
DX05_RS04260	COG0552	protein localization to endoplasmic reticulum
DX05_RS04270	COG3344	reverse transcriptase
DX05_RS04275	COG3689	TIGRFAM TIGR03943 family protein
DX05_RS04280	COG0701	Predicted permease
DX05_RS04295	COG2183	response to ionizing radiation
DX05_RS04300	COG3091	SprT-like family
DX05_RS04305	COG1983	PspC domain protein
DX05_RS04340	COG0826	peptidase U32
DX05_RS04345	COG4443	Transcriptional Coactivator p15 (PC4)
DX05_RS04355	COG1914	H( )-stimulated, divalent metal cation uptake system
DX05_RS04370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DX05_RS04370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DX05_RS04395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DX05_RS04405	COG3344	reverse transcriptase
DX05_RS04430	COG1164	Oligoendopeptidase f
DX05_RS04440	COG0772	Belongs to the SEDS family
DX05_RS04460	COG0768	penicillin binding
DX05_RS04475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DX05_RS04480	COG2223	nitrite transmembrane transporter activity
DX05_RS04505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DX05_RS04510	COG2011	ABC-type metal ion transport system permease component
DX05_RS04515	COG1464	Belongs to the NlpA lipoprotein family
DX05_RS04520	COG0513	Belongs to the DEAD box helicase family
DX05_RS04530	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DX05_RS04535	COG0204	Acyl-transferase
DX05_RS04540	COG1596	polysaccharide export
DX05_RS04540	COG1555	photosystem II stabilization
DX05_RS04545	COG2333	competence protein COMEC
DX05_RS04545	COG0658	competence protein
DX05_RS04550	COG0561	phosphatase activity
DX05_RS04555	COG1609	Transcriptional regulator
DX05_RS04560	COG0657	acetylesterase activity
DX05_RS04575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DX05_RS04580	COG3711	transcriptional antiterminator
DX05_RS04585	COG1263	PTS System
DX05_RS04585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DX05_RS04585	COG2190	(PTS) system
DX05_RS04595	COG3835	regulator
DX05_RS04600	COG1929	Belongs to the glycerate kinase type-1 family
DX05_RS04605	COG2610	gluconate transmembrane transporter activity
DX05_RS04615	COG1846	Transcriptional regulator
DX05_RS04620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DX05_RS04630	COG0363	glucosamine-6-phosphate deaminase activity
DX05_RS04635	COG0435	Glutathione S-transferase
DX05_RS04640	COG1187	pseudouridine synthase activity
DX05_RS04660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DX05_RS04665	COG4122	O-methyltransferase activity
DX05_RS04675	COG4894	glucomannan catabolic process
DX05_RS04690	COG1442	glycosyl transferase family 8
DX05_RS04700	COG1476	TRANSCRIPTIONal
DX05_RS04715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DX05_RS04720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DX05_RS04725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DX05_RS04740	COG1012	belongs to the aldehyde dehydrogenase family
DX05_RS04745	COG0726	polysaccharide deacetylase
DX05_RS04755	COG0513	Belongs to the DEAD box helicase family
DX05_RS04765	COG5433	transposase activity
DX05_RS04770	COG1956	GAF domain-containing protein
DX05_RS04775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DX05_RS04785	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DX05_RS04785	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DX05_RS04790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DX05_RS04815	COG4721	ABC-type cobalt transport system, permease component
DX05_RS04820	COG1122	ATPase activity
DX05_RS04830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DX05_RS04840	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DX05_RS04850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DX05_RS04860	COG4109	DRTGG domain
DX05_RS04865	COG0024	Methionine aminopeptidase
DX05_RS04875	COG2246	polysaccharide biosynthetic process
DX05_RS04880	COG4708	membrane
DX05_RS04885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DX05_RS04890	COG1597	lipid kinase activity
DX05_RS04895	COG1523	belongs to the glycosyl hydrolase 13 family
DX05_RS04905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DX05_RS04910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DX05_RS04965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DX05_RS04990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DX05_RS04990	COG0072	phenylalanine-tRNA ligase activity
DX05_RS05000	COG2321	neutral zinc metallopeptidase
DX05_RS05005	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DX05_RS05010	COG1074	ATP-dependent DNA helicase activity
DX05_RS05020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DX05_RS05025	COG0488	(ABC) transporter
DX05_RS05030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DX05_RS05035	COG0022	dehydrogenase e1 component
DX05_RS05035	COG0508	dehydrogenase complex catalyzes the overall conversion of
DX05_RS05040	COG0508	dehydrogenase complex catalyzes the overall conversion of
DX05_RS05050	COG0095	Lipoate-protein ligase
DX05_RS05060	COG3344	reverse transcriptase
DX05_RS05065	COG3442	glutamine amidotransferase
DX05_RS05070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DX05_RS05075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DX05_RS05105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DX05_RS05115	COG0647	UMP catabolic process
DX05_RS05125	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
DX05_RS05130	COG1518	maintenance of DNA repeat elements
DX05_RS05135	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DX05_RS05150	COG0481	GTPase activity
DX05_RS05160	COG1418	mRNA catabolic process
DX05_RS05165	COG0456	acetyltransferase
DX05_RS05175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DX05_RS05210	COG1131	(ABC) transporter
DX05_RS05215	COG1725	Transcriptional regulator
DX05_RS05225	COG0205	6-phosphofructokinase activity
DX05_RS05230	COG0469	pyruvate kinase activity
DX05_RS05240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DX05_RS05245	COG2824	Alkylphosphonate utilization operon protein PhnA
DX05_RS05250	COG0765	amino acid transport
DX05_RS05255	COG1126	abc transporter atp-binding protein
DX05_RS05275	COG1072	(Pantothenic acid kinase))
DX05_RS05280	COG2813	Specifically methylates the guanine in position
DX05_RS05290	COG1744	ABC transporter substrate-binding protein PnrA-like
DX05_RS05295	COG3845	ABC transporter
DX05_RS05300	COG4603	Belongs to the binding-protein-dependent transport system permease family
DX05_RS05305	COG1079	Belongs to the binding-protein-dependent transport system permease family
DX05_RS05325	COG3764	Sortase (surface protein transpeptidase)
DX05_RS05330	COG0346	lactoylglutathione lyase activity
DX05_RS05335	COG3344	reverse transcriptase
DX05_RS05360	COG2188	Transcriptional regulator
DX05_RS05365	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DX05_RS05375	COG1464	Belongs to the NlpA lipoprotein family
DX05_RS05390	COG1136	(ABC) transporter
DX05_RS05400	COG0745	RESPONSE REGULATOR receiver
DX05_RS05405	COG5002	protein histidine kinase activity
DX05_RS05410	COG4974	Belongs to the 'phage' integrase family
DX05_RS05415	COG4166	transmembrane transport
DX05_RS05430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DX05_RS05435	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DX05_RS05440	COG5002	protein histidine kinase activity
DX05_RS05445	COG0745	RESPONSE REGULATOR receiver
DX05_RS05455	COG0704	Plays a role in the regulation of phosphate uptake
DX05_RS05460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DX05_RS05465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DX05_RS05470	COG0581	inorganic phosphate transmembrane transporter activity
DX05_RS05475	COG0573	inorganic phosphate transmembrane transporter activity
DX05_RS05485	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DX05_RS05485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DX05_RS05490	COG0483	inositol monophosphate 1-phosphatase activity
DX05_RS05495	COG4476	Belongs to the UPF0223 family
DX05_RS05505	COG0196	riboflavin kinase activity
DX05_RS05510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DX05_RS05540	COG1136	(ABC) transporter
DX05_RS05545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DX05_RS05550	COG0758	DNA mediated transformation
DX05_RS05555	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DX05_RS05560	COG4604	ABC transporter, ATP-binding protein
DX05_RS05570	COG4605	iron ion homeostasis
DX05_RS05575	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX05_RS05580	COG0110	maltose O-acetyltransferase activity
DX05_RS05590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DX05_RS05595	COG1376	ErfK ybiS ycfS ynhG family protein
DX05_RS05600	COG1966	Carbon starvation protein
DX05_RS05605	COG3279	Response regulator of the LytR AlgR family
DX05_RS05610	COG3275	phosphorelay sensor kinase activity
DX05_RS05740	COG0505	Belongs to the CarA family
DX05_RS05750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DX05_RS05755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DX05_RS05760	COG0284	orotidine-5'-phosphate decarboxylase activity
DX05_RS05770	COG0488	(ABC) transporter
DX05_RS05780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DX05_RS05790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DX05_RS05795	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DX05_RS05830	COG0095	Lipoate-protein ligase
DX05_RS05840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DX05_RS05845	COG4684	Psort location CytoplasmicMembrane, score
DX05_RS05850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DX05_RS05860	COG2801	Transposase and inactivated derivatives
DX05_RS05870	COG1132	(ABC) transporter
DX05_RS05890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DX05_RS05900	COG2890	protein-(glutamine-N5) methyltransferase activity
DX05_RS05905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DX05_RS05915	COG1942	4-Oxalocrotonate Tautomerase
DX05_RS05930	COG0431	NADPH-dependent FMN reductase
DX05_RS05930	COG1053	succinate dehydrogenase
DX05_RS05930	COG3976	FMN-binding domain protein
DX05_RS05940	COG2233	PERMEase
DX05_RS05950	COG0516	GMP reductase activity
DX05_RS05955	COG0477	Major facilitator Superfamily
DX05_RS05970	COG4221	oxidoreductase activity
DX05_RS05975	COG0280	phosphate acetyltransferase
DX05_RS05980	COG0564	pseudouridine synthase activity
DX05_RS05985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DX05_RS05990	COG2357	RelA SpoT domain protein
DX05_RS06005	COG1104	cysteine desulfurase activity
DX05_RS06025	COG0628	permease
DX05_RS06040	COG0561	phosphatase activity
DX05_RS06050	COG0038	chloride channel
DX05_RS06060	COG1177	transmembrane transport
DX05_RS06065	COG1176	ABC-type spermidine putrescine transport system, permease component I
DX05_RS06075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DX05_RS06080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DX05_RS06100	COG0285	dihydrofolate synthase activity
DX05_RS06105	COG2962	Rard protein
DX05_RS06120	COG0726	polysaccharide deacetylase
DX05_RS06130	COG3344	reverse transcriptase
DX05_RS06135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DX05_RS06140	COG1012	belongs to the aldehyde dehydrogenase family
DX05_RS06215	COG2261	transglycosylase associated protein
DX05_RS06240	COG1115	amino acid carrier protein
DX05_RS06245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DX05_RS06255	COG1346	cytolysis
DX05_RS06290	COG4974	Belongs to the 'phage' integrase family
DX05_RS06305	COG0539	negative regulation of cytoplasmic translation
DX05_RS06325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DX05_RS06335	COG0187	DNA topoisomerase II activity
DX05_RS06340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DX05_RS06345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DX05_RS06355	COG2755	lipolytic protein G-D-S-L family
DX05_RS06355	COG1083	cytidylyl-transferase
DX05_RS06370	COG2089	acid synthase
DX05_RS06395	COG1442	glycosyl transferase family 8
DX05_RS06395	COG1216	Glycosyl transferase, family 2
DX05_RS06400	COG1442	glycosyl transferase family 8
DX05_RS06400	COG1216	Glycosyl transferase, family 2
DX05_RS06415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DX05_RS06440	COG1316	TRANSCRIPTIONal
DX05_RS06465	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DX05_RS06480	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DX05_RS06500	COG3842	ATPase activity
DX05_RS06515	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DX05_RS06520	COG3527	Alpha-acetolactate decarboxylase
DX05_RS06525	COG0028	Belongs to the TPP enzyme family
DX05_RS06530	COG0457	Tetratricopeptide repeat
DX05_RS06535	COG0628	permease
DX05_RS06545	COG1051	belongs to the nudix hydrolase family
DX05_RS06550	COG5492	domain, Protein
DX05_RS06555	COG1088	dTDP-glucose 4,6-dehydratase activity
DX05_RS06565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DX05_RS06570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DX05_RS06580	COG2384	SAM-dependent methyltransferase
DX05_RS06600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DX05_RS06600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DX05_RS06605	COG0300	oxidoreductase activity
DX05_RS06620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DX05_RS06660	COG1573	uracil-dna glycosylase
DX05_RS06665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DX05_RS06675	COG0584	glycerophosphoryl diester phosphodiesterase
DX05_RS06680	COG0322	excinuclease ABC activity
DX05_RS06690	COG0534	Mate efflux family protein
DX05_RS06725	COG2801	Transposase and inactivated derivatives
DX05_RS06745	COG0803	Belongs to the bacterial solute-binding protein 9 family
DX05_RS06750	COG5433	transposase activity
DX05_RS06775	COG2176	DNA-directed DNA polymerase activity
DX05_RS06785	COG4974	Belongs to the 'phage' integrase family
DX05_RS06815	COG1674	ftsk spoiiie
DX05_RS06855	COG2040	homocysteine
DX05_RS06895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DX05_RS06905	COG3425	synthase
DX05_RS06920	COG1272	protein, Hemolysin III
DX05_RS06965	COG0745	RESPONSE REGULATOR receiver
DX05_RS06970	COG2357	RelA SpoT domain protein
DX05_RS06975	COG1132	(ABC) transporter
DX05_RS06990	COG0737	Belongs to the 5'-nucleotidase family
DX05_RS06995	COG0242	peptide deformylase activity
DX05_RS07000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DX05_RS07010	COG1132	(ABC) transporter
DX05_RS07025	COG0488	(ABC) transporter
DX05_RS07045	COG5433	transposase activity
DX05_RS07060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DX05_RS07060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DX05_RS07060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DX05_RS07065	COG1105	Belongs to the carbohydrate kinase PfkB family
DX05_RS07070	COG1349	DNA-binding transcription factor activity
DX05_RS07125	COG1837	Belongs to the UPF0109 family
DX05_RS07130	COG0228	four-way junction DNA binding
DX05_RS07135	COG0577	efflux transmembrane transporter activity
DX05_RS07140	COG1136	(ABC) transporter
DX05_RS07145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DX05_RS07155	COG0505	Belongs to the CarA family
DX05_RS07165	COG0564	pseudouridine synthase activity
DX05_RS07175	COG0583	DNA-binding transcription factor activity
DX05_RS07180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DX05_RS07200	COG0301	tRNA thio-modification
DX05_RS07205	COG1104	cysteine desulfurase activity
DX05_RS07215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DX05_RS07220	COG3679	Belongs to the UPF0342 family
DX05_RS07225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DX05_RS07240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DX05_RS07245	COG1368	sulfuric ester hydrolase activity
DX05_RS07250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DX05_RS07260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DX05_RS07265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DX05_RS07290	COG2244	polysaccharide biosynthetic process
DX05_RS07295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DX05_RS07300	COG1120	ATPase activity
DX05_RS07305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DX05_RS07310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX05_RS07315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DX05_RS07330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DX05_RS07335	COG1253	flavin adenine dinucleotide binding
DX05_RS07340	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DX05_RS07345	COG1242	4 iron, 4 sulfur cluster binding
DX05_RS07350	COG0671	phosphoesterase, PA-phosphatase related
DX05_RS07355	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DX05_RS07390	COG0297	glycogen (starch) synthase activity
DX05_RS07430	COG3475	LICD family
DX05_RS07445	COG0463	Glycosyl transferase, family 2
DX05_RS07450	COG1215	transferase activity, transferring glycosyl groups
DX05_RS07460	COG1091	dTDP-4-dehydrorhamnose reductase activity
DX05_RS07465	COG2151	metal-sulfur cluster biosynthetic enzyme
DX05_RS07470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DX05_RS07475	COG0358	DNA primase activity
DX05_RS07480	COG1970	mechanosensitive ion channel activity
DX05_RS07495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DX05_RS07510	COG1054	Belongs to the UPF0176 family
DX05_RS07520	COG2271	Major facilitator Superfamily
DX05_RS07530	COG0058	SHG alpha-glucan phosphorylase activity
DX05_RS07535	COG1640	4-alpha-glucanotransferase
DX05_RS07540	COG1609	Transcriptional regulator
DX05_RS07550	COG1175	transmembrane transport
DX05_RS07555	COG3833	ABC-type maltose transport systems, permease component
DX05_RS07560	COG3104	oligopeptide transport
DX05_RS07580	COG0438	transferase activity, transferring glycosyl groups
DX05_RS07605	COG0201	protein transport
DX05_RS07610	COG1442	glycosyl transferase family 8
DX05_RS07615	COG1442	glycosyl transferase family 8
DX05_RS07615	COG1216	Glycosyl transferase, family 2
DX05_RS07620	COG1442	glycosyl transferase family 8
DX05_RS07625	COG1442	glycosyl transferase family 8
DX05_RS07625	COG1216	Glycosyl transferase, family 2
DX05_RS07630	COG1442	glycosyl transferase family 8
DX05_RS07660	COG0765	amino acid transport
DX05_RS07665	COG1126	abc transporter atp-binding protein
DX05_RS07695	COG2309	aminopeptidase activity
DX05_RS07705	COG0154	amidase activity
DX05_RS07710	COG1187	pseudouridine synthase activity
DX05_RS07715	COG0656	L-ascorbic acid biosynthetic process
DX05_RS07720	COG0778	Nitroreductase
DX05_RS07725	COG0346	lactoylglutathione lyase activity
DX05_RS07730	COG0463	Glycosyl transferase, family 2
DX05_RS07735	COG1113	amino acid transport
DX05_RS07740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DX05_RS07745	COG0557	exoribonuclease II activity
DX05_RS07755	COG2814	Major facilitator Superfamily
DX05_RS07765	COG1131	(ABC) transporter
DX05_RS07775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DX05_RS07780	COG1396	sequence-specific DNA binding
DX05_RS07820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DX05_RS07825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DX05_RS07845	COG1702	phosphate starvation-inducible protein PhoH
DX05_RS07870	COG0233	cytoplasmic translational termination
DX05_RS07885	COG0444	Belongs to the ABC transporter superfamily
DX05_RS07890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DX05_RS07900	COG0747	negative chemotaxis
DX05_RS07905	COG0081	regulation of translation
DX05_RS07925	COG1473	amidohydrolase
DX05_RS07930	COG0583	DNA-binding transcription factor activity
DX05_RS07940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DX05_RS07945	COG1674	ftsk spoiiie
DX05_RS07950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DX05_RS07975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DX05_RS08005	COG0673	inositol 2-dehydrogenase activity
DX05_RS08020	COG1028	Short-chain dehydrogenase reductase Sdr
DX05_RS08070	COG3344	reverse transcriptase
DX05_RS08075	COG1114	Component of the transport system for branched-chain amino acids
DX05_RS08080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DX05_RS08080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DX05_RS08100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DX05_RS08110	COG0708	Exodeoxyribonuclease III
DX05_RS08120	COG1393	Belongs to the ArsC family
DX05_RS08125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DX05_RS08130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DX05_RS08140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DX05_RS08150	COG3344	reverse transcriptase
DX05_RS08170	COG0470	DNA polymerase III
DX05_RS08180	COG0517	IMP dehydrogenase activity
DX05_RS08220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DX05_RS08225	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DX05_RS08235	COG0531	amino acid
DX05_RS08240	COG0569	domain protein
DX05_RS08255	COG1187	pseudouridine synthase activity
DX05_RS08265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DX05_RS08270	COG0582	viral genome integration into host DNA
DX05_RS08290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DX05_RS08305	COG1827	regulation of RNA biosynthetic process
DX05_RS08320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DX05_RS08325	COG1254	Belongs to the acylphosphatase family
DX05_RS08330	COG0706	membrane insertase activity
DX05_RS08335	COG0765	amino acid transport
DX05_RS08340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DX05_RS08355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DX05_RS08365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DX05_RS08385	COG1484	DNA-dependent DNA replication
DX05_RS08400	COG5002	protein histidine kinase activity
DX05_RS08405	COG0745	RESPONSE REGULATOR receiver
DX05_RS08415	COG0501	Belongs to the peptidase M48B family
DX05_RS08420	COG1704	LemA family
DX05_RS08425	COG0357	Ribosomal RNA small subunit methyltransferase G
DX05_RS08430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DX05_RS08435	COG0569	domain protein
DX05_RS08445	COG1122	ATPase activity
DX05_RS08455	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DX05_RS08460	COG1114	Component of the transport system for branched-chain amino acids
DX05_RS08465	COG1063	alcohol dehydrogenase
DX05_RS08495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DX05_RS08500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DX05_RS08505	COG0217	transcriptional regulatory protein
DX05_RS08510	COG2376	Dihydroxyacetone kinase
DX05_RS08515	COG1309	transcriptional regulator
DX05_RS08520	COG2376	Dihydroxyacetone kinase
DX05_RS08525	COG1461	Dihydroxyacetone kinase
DX05_RS08530	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DX05_RS08535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DX05_RS08545	COG0789	Transcriptional regulator
DX05_RS08550	COG1323	Belongs to the UPF0348 family
DX05_RS08560	COG2226	methyltransferase
DX05_RS08565	COG0799	negative regulation of ribosome biogenesis
DX05_RS08575	COG1713	HD superfamily hydrolase involved in NAD metabolism
DX05_RS08580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DX05_RS08585	COG1534	Rna-binding protein
DX05_RS08590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DX05_RS08595	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DX05_RS08605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DX05_RS08610	COG0154	amidase activity
DX05_RS08615	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DX05_RS08620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DX05_RS08620	COG0574	Belongs to the PEP-utilizing enzyme family
DX05_RS08625	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DX05_RS08630	COG0517	IMP dehydrogenase activity
DX05_RS08640	COG1335	isochorismatase
DX05_RS08645	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DX05_RS08650	COG0436	Aminotransferase
DX05_RS08655	COG0589	response to stress
DX05_RS08660	COG0561	phosphatase activity
DX05_RS08665	COG0252	asparaginase activity
DX05_RS08675	COG4989	oxidoreductase activity
DX05_RS08680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DX05_RS08685	COG1705	Flagellar rod assembly protein muramidase FlgJ
DX05_RS08685	COG3942	CHAP domain
DX05_RS08695	COG0736	holo-[acyl-carrier-protein] synthase activity
DX05_RS08700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DX05_RS08710	COG5433	transposase activity
DX05_RS08715	COG1482	cell wall glycoprotein biosynthetic process
DX05_RS08720	COG1940	carbohydrate kinase activity
DX05_RS08730	COG2190	(PTS) system
DX05_RS08730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DX05_RS08730	COG1263	PTS System
DX05_RS08735	COG1621	beta-fructofuranosidase activity
DX05_RS08740	COG1609	Transcriptional regulator
DX05_RS08745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DX05_RS08755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DX05_RS08760	COG1132	(ABC) transporter
DX05_RS08765	COG1132	(ABC) transporter
DX05_RS08795	COG1021	2,3-dihydroxybenzoate-AMP ligase
DX05_RS08805	COG2131	deaminase
DX05_RS08810	COG0006	proline dipeptidase activity
DX05_RS08820	COG2814	Major facilitator Superfamily
DX05_RS08845	COG3344	reverse transcriptase
DX05_RS08850	COG0629	single-stranded DNA binding
DX05_RS08855	COG0360	Binds together with S18 to 16S ribosomal RNA
DX05_RS08860	COG1194	a g-specific adenine glycosylase
DX05_RS08870	COG3118	belongs to the thioredoxin family
DX05_RS08880	COG1193	negative regulation of DNA recombination
DX05_RS08895	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DX05_RS08900	COG0681	Belongs to the peptidase S26 family
DX05_RS08905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DX05_RS08920	COG3344	reverse transcriptase
DX05_RS08930	COG1882	Formate acetyltransferase
DX05_RS08935	COG3576	pyridoxamine 5-phosphate
DX05_RS08940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DX05_RS08955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DX05_RS08965	COG2814	Major facilitator Superfamily
DX05_RS08970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DX05_RS08975	COG2936	dipeptidyl-peptidase activity
DX05_RS08985	COG0142	geranyltranstransferase activity
DX05_RS08990	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DX05_RS08995	COG4988	ABC transporter
DX05_RS09000	COG1294	oxidase, subunit
DX05_RS09005	COG1271	oxidase subunit
DX05_RS09010	COG1252	NADH dehydrogenase
DX05_RS09025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DX05_RS09030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DX05_RS09035	COG0789	Transcriptional regulator
DX05_RS09050	COG2081	HI0933 family
DX05_RS09070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DX05_RS09075	COG0456	acetyltransferase
DX05_RS09080	COG1214	PFAM Peptidase M22, glycoprotease
DX05_RS09095	COG3942	CHAP domain
DX05_RS09100	COG0174	glutamine synthetase
DX05_RS09105	COG0789	Transcriptional regulator
DX05_RS09120	COG0126	phosphoglycerate kinase activity
DX05_RS09125	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DX05_RS09135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DX05_RS09150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DX05_RS09175	COG1162	GTPase activity
DX05_RS09185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DX05_RS09200	COG0084	hydrolase, TatD family'
DX05_RS09225	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DX05_RS09230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DX05_RS09235	COG1696	Membrane protein involved in D-alanine export
DX05_RS09250	COG5002	protein histidine kinase activity
DX05_RS09255	COG0745	RESPONSE REGULATOR receiver
DX05_RS09260	COG5433	transposase activity
DX05_RS09270	COG3314	Sporulation integral membrane protein YlbJ
DX05_RS09335	COG0791	NLP P60 protein
DX05_RS09335	COG0741	lytic transglycosylase activity
DX05_RS09365	COG2946	Replication initiation factor
DX05_RS09370	COG1674	ftsk spoiiie
DX05_RS09390	COG3448	diguanylate cyclase activity
DX05_RS09390	COG4175	Glycine betaine
DX05_RS09395	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DX05_RS09415	COG1070	Carbohydrate kinase
DX05_RS09425	COG3775	system Galactitol-specific IIC component
DX05_RS09430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DX05_RS09440	COG1609	Transcriptional regulator
DX05_RS09490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DX05_RS09520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DX05_RS09525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DX05_RS09530	COG1428	Deoxynucleoside kinase
DX05_RS09540	COG0542	response to heat
DX05_RS09545	COG4463	regulation of RNA biosynthetic process
DX05_RS09555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DX05_RS09565	COG0450	alkyl hydroperoxide reductase
DX05_RS09595	COG3177	Filamentation induced by cAMP protein fic
DX05_RS09660	COG2946	Replication initiation factor
DX05_RS09670	COG4974	Belongs to the 'phage' integrase family
DX05_RS09685	COG1619	proteins homologs of microcin C7 resistance protein MccF
DX05_RS09690	COG3590	peptidase
DX05_RS09715	COG1609	Transcriptional regulator
DX05_RS09725	COG3716	PTS system mannose fructose sorbose family IID component
DX05_RS09730	COG3715	PTS system
DX05_RS09735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DX05_RS09740	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DX05_RS09750	COG1028	Short-chain dehydrogenase reductase Sdr
DX05_RS09785	COG2176	DNA-directed DNA polymerase activity
DX05_RS09790	COG1388	LysM domain
DX05_RS09790	COG1705	Flagellar rod assembly protein muramidase FlgJ
DX05_RS09805	COG4589	Belongs to the CDS family
DX05_RS09810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DX05_RS09815	COG1862	Preprotein translocase
DX05_RS09835	COG3493	citrate carrier protein
DX05_RS09840	COG3290	protein histidine kinase activity
DX05_RS09845	COG4565	transcriptional regulatory protein
DX05_RS09850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DX05_RS09860	COG3842	ATPase activity
DX05_RS09930	COG1490	D-aminoacyl-tRNA deacylase activity
DX05_RS09940	COG0737	Belongs to the 5'-nucleotidase family
DX05_RS09950	COG1363	Peptidase, m42
DX05_RS09970	COG2207	Transcriptional regulator
DX05_RS09970	COG4753	response regulator
DX05_RS09975	COG2972	Histidine kinase
DX05_RS09980	COG3716	PTS system mannose fructose sorbose family IID component
DX05_RS09985	COG3715	PTS system
DX05_RS10010	COG1131	(ABC) transporter
DX05_RS10020	COG3279	Response regulator of the LytR AlgR family
DX05_RS10030	COG2190	(PTS) system
DX05_RS10030	COG1263	PTS System
DX05_RS10030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DX05_RS10035	COG5002	protein histidine kinase activity
DX05_RS10040	COG0745	RESPONSE REGULATOR receiver
DX05_RS10050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DX05_RS10055	COG0581	inorganic phosphate transmembrane transporter activity
DX05_RS10060	COG0573	inorganic phosphate transmembrane transporter activity
DX05_RS10075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DX05_RS10110	COG0456	acetyltransferase
DX05_RS10115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DX05_RS10185	COG1131	(ABC) transporter
DX05_RS10195	COG1396	sequence-specific DNA binding
DX05_RS10200	COG3344	reverse transcriptase
DX05_RS10215	COG1694	Mazg nucleotide pyrophosphohydrolase
DX05_RS10230	COG2897	thiosulfate sulfurtransferase activity
DX05_RS10245	COG0371	Dehydrogenase
DX05_RS10255	COG2801	Transposase and inactivated derivatives
DX05_RS10265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DX05_RS10265	COG0646	methionine synthase
DX05_RS10280	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DX05_RS10290	COG0745	RESPONSE REGULATOR receiver
DX05_RS10295	COG2770	Histidine kinase
DX05_RS10295	COG2205	protein histidine kinase activity
DX05_RS10315	COG5433	transposase activity
DX05_RS10320	COG2814	Major facilitator Superfamily
DX05_RS10325	COG4667	esterase of the alpha-beta hydrolase superfamily
DX05_RS10345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DX05_RS10350	COG0564	pseudouridine synthase activity
DX05_RS10375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DX05_RS10380	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DX05_RS10400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DX05_RS10405	COG1116	anion transmembrane transporter activity
DX05_RS10405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DX05_RS10410	COG4120	Belongs to the binding-protein-dependent transport system permease family
DX05_RS10420	COG0561	phosphatase activity
DX05_RS10425	COG2514	catechol 2,3-dioxygenase activity
DX05_RS10430	COG3022	response to hydroperoxide
DX05_RS10435	COG0602	queuosine metabolic process
DX05_RS10455	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DX05_RS10455	COG1328	CTP reductase activity
DX05_RS10475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DX05_RS10485	COG1393	Belongs to the ArsC family
DX05_RS10490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DX05_RS10495	COG1546	Belongs to the CinA family
DX05_RS10495	COG1058	Belongs to the CinA family
DX05_RS10500	COG2818	Glycosylase
DX05_RS10535	COG0018	arginyl-trna synthetase
DX05_RS10545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DX05_RS10550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DX05_RS10570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DX05_RS10580	COG4974	Belongs to the 'phage' integrase family
DX05_RS10590	COG2946	Replication initiation factor
DX05_RS10620	COG3177	Filamentation induced by cAMP protein fic
DX05_RS10645	COG2801	Transposase and inactivated derivatives
DX05_RS10685	COG4974	Belongs to the 'phage' integrase family
DX05_RS10695	COG0745	RESPONSE REGULATOR receiver
DX05_RS10700	COG5002	protein histidine kinase activity
DX05_RS10705	COG3344	reverse transcriptase
DX05_RS10710	COG1288	antiporter activity
DX05_RS10720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DX05_RS10725	COG3852	Histidine kinase
DX05_RS10730	COG0784	Response regulator, receiver
DX05_RS10735	COG0517	IMP dehydrogenase activity
DX05_RS10735	COG1125	glycine betaine transport
DX05_RS10740	COG1174	glycine betaine transport
DX05_RS10745	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DX05_RS10745	COG0392	lysyltransferase activity
DX05_RS10755	COG3759	membrane
DX05_RS10875	COG0582	viral genome integration into host DNA
DX05_RS10890	COG0305	Participates in initiation and elongation during chromosome replication
DX05_RS10910	COG5433	transposase activity
DX05_RS10915	COG2095	MarC family integral membrane protein
DX05_RS10920	COG0482	sulfurtransferase activity
DX05_RS10925	COG1760	l-serine dehydratase
DX05_RS10930	COG1760	l-serine dehydratase
DX05_RS10940	COG0741	lytic transglycosylase activity
DX05_RS10965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DX05_RS10970	COG0612	Peptidase, M16
DX05_RS10975	COG0612	Peptidase, M16
DX05_RS10980	COG2501	S4 domain
DX05_RS10995	COG3344	reverse transcriptase
DX05_RS11010	COG0517	IMP dehydrogenase activity
DX05_RS11010	COG0516	GMP reductase activity
DX05_RS11020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DX05_RS11035	COG0454	-acetyltransferase
DX05_RS11050	COG0549	Belongs to the carbamate kinase family
DX05_RS11065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DX05_RS11070	COG0488	(ABC) transporter
DX05_RS11075	COG4485	Bacterial membrane protein, YfhO
DX05_RS11100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DX05_RS11105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DX05_RS11110	COG1475	DNA binding