locus-tag	class	description
HKK59_RS00010	COG0592	DNA-directed DNA polymerase activity
HKK59_RS00015	COG1597	lipid kinase activity
HKK59_RS00030	COG0012	GTP binding
HKK59_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKK59_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HKK59_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKK59_RS00260	COG0436	Aminotransferase
HKK59_RS00280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK59_RS00290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKK59_RS00305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKK59_RS00340	COG1175	transmembrane transport
HKK59_RS00345	COG0395	ABC-type sugar transport system, permease component
HKK59_RS00360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK59_RS00370	COG3458	cephalosporin-C deacetylase activity
HKK59_RS00385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HKK59_RS00400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKK59_RS00415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKK59_RS00425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HKK59_RS00425	COG2755	lipolytic protein G-D-S-L family
HKK59_RS00430	COG1454	alcohol dehydrogenase
HKK59_RS00430	COG1012	belongs to the aldehyde dehydrogenase family
HKK59_RS00435	COG1064	alcohol dehydrogenase
HKK59_RS00445	COG0534	Mate efflux family protein
HKK59_RS00555	COG0201	protein transport
HKK59_RS00575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HKK59_RS00585	COG0202	RNA polymerase activity
HKK59_RS00710	COG3344	reverse transcriptase
HKK59_RS00730	COG1705	Flagellar rod assembly protein muramidase FlgJ
HKK59_RS00745	COG0443	Heat shock 70 kDa protein
HKK59_RS00755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK59_RS00765	COG0351	phosphomethylpyrimidine kinase
HKK59_RS00770	COG4720	Psort location CytoplasmicMembrane, score
HKK59_RS00780	COG0668	transmembrane transport
HKK59_RS00810	COG0756	dUTP diphosphatase activity
HKK59_RS00825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKK59_RS00840	COG1879	ABC-type sugar transport system periplasmic component
HKK59_RS00845	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK59_RS00860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK59_RS00865	COG1609	Transcriptional regulator
HKK59_RS00870	COG0577	efflux transmembrane transporter activity
HKK59_RS00875	COG1136	(ABC) transporter
HKK59_RS00880	COG0745	RESPONSE REGULATOR receiver
HKK59_RS00885	COG5002	protein histidine kinase activity
HKK59_RS00900	COG0191	fructose-bisphosphate aldolase activity
HKK59_RS00920	COG1461	Dihydroxyacetone kinase
HKK59_RS00950	COG1755	Isoprenylcysteine carboxyl methyltransferase
HKK59_RS00955	COG5002	protein histidine kinase activity
HKK59_RS00960	COG0745	RESPONSE REGULATOR receiver
HKK59_RS00975	COG1126	abc transporter atp-binding protein
HKK59_RS00980	COG0765	amino acid transport
HKK59_RS01000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKK59_RS01010	COG0719	Fe-S assembly protein
HKK59_RS01015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKK59_RS01025	COG0719	Fe-S assembly protein
HKK59_RS01030	COG1686	Belongs to the peptidase S11 family
HKK59_RS01035	COG1686	Belongs to the peptidase S11 family
HKK59_RS01040	COG4166	transmembrane transport
HKK59_RS01045	COG0601	transmembrane transport
HKK59_RS01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK59_RS01055	COG0444	Belongs to the ABC transporter superfamily
HKK59_RS01060	COG4608	Belongs to the ABC transporter superfamily
HKK59_RS01100	COG1121	(ABC) transporter
HKK59_RS01105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKK59_RS01140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKK59_RS01205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HKK59_RS01210	COG1363	Peptidase, m42
HKK59_RS01225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKK59_RS01230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKK59_RS01245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK59_RS01265	COG1346	cytolysis
HKK59_RS01275	COG0601	transmembrane transport
HKK59_RS01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK59_RS01285	COG1122	ATPase activity
HKK59_RS01290	COG1124	(ABC) transporter
HKK59_RS01295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK59_RS01295	COG1263	PTS System
HKK59_RS01300	COG0366	Alpha amylase catalytic
HKK59_RS01305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK59_RS01320	COG3959	Transketolase, thiamine diphosphate binding domain
HKK59_RS01325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HKK59_RS01330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKK59_RS01350	COG1045	serine acetyltransferase
HKK59_RS01365	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HKK59_RS01385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HKK59_RS01395	COG4974	Belongs to the 'phage' integrase family
HKK59_RS01485	COG1396	sequence-specific DNA binding
HKK59_RS01490	COG2814	Major facilitator Superfamily
HKK59_RS01500	COG1732	Glycine betaine
HKK59_RS01635	COG0519	Catalyzes the synthesis of GMP from XMP
HKK59_RS01680	COG1695	Transcriptional regulator
HKK59_RS01695	COG1755	Isoprenylcysteine carboxyl methyltransferase
HKK59_RS01735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKK59_RS01740	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK59_RS01760	COG1131	(ABC) transporter
HKK59_RS01770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK59_RS01770	COG1263	PTS System
HKK59_RS01770	COG2190	(PTS) system
HKK59_RS01775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HKK59_RS01795	COG0768	penicillin binding
HKK59_RS01805	COG0513	Belongs to the DEAD box helicase family
HKK59_RS01820	COG1126	abc transporter atp-binding protein
HKK59_RS01830	COG0492	ferredoxin-NADP+ reductase activity
HKK59_RS01835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HKK59_RS01845	COG3579	cysteine-type endopeptidase activity
HKK59_RS01850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKK59_RS01875	COG0116	Belongs to the methyltransferase superfamily
HKK59_RS01885	COG1854	S-ribosylhomocysteine lyase activity
HKK59_RS01890	COG4372	Transposase
HKK59_RS01890	COG1418	mRNA catabolic process
HKK59_RS01895	COG1131	(ABC) transporter
HKK59_RS01905	COG4585	Histidine kinase
HKK59_RS01910	COG2197	response regulator
HKK59_RS01920	COG0194	GDP metabolic process
HKK59_RS01930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKK59_RS01935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKK59_RS01940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKK59_RS01940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HKK59_RS01950	COG0515	serine threonine protein kinase
HKK59_RS01950	COG2815	serine threonine protein kinase
HKK59_RS01960	COG4585	Histidine kinase
HKK59_RS01965	COG2197	response regulator
HKK59_RS01975	COG1098	S1 RNA binding domain
HKK59_RS01980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKK59_RS01985	COG1349	DNA-binding transcription factor activity
HKK59_RS01995	COG1447	Phosphotransferase system cellobiose-specific component IIA
HKK59_RS02005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKK59_RS02010	COG1882	Formate acetyltransferase
HKK59_RS02030	COG1739	Uncharacterized protein family UPF0029
HKK59_RS02035	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HKK59_RS02040	COG1040	competence protein
HKK59_RS02075	COG0527	aspartate kinase activity
HKK59_RS02080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK59_RS02085	COG1024	Enoyl-CoA hydratase
HKK59_RS02095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKK59_RS02105	COG2070	2-Nitropropane dioxygenase
HKK59_RS02110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HKK59_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
HKK59_RS02120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK59_RS02135	COG0439	Biotin carboxylase
HKK59_RS02155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HKK59_RS02170	COG3716	PTS system mannose fructose sorbose family IID component
HKK59_RS02175	COG3715	PTS system
HKK59_RS02185	COG0561	phosphatase activity
HKK59_RS02200	COG2252	PERMEase
HKK59_RS02205	COG0802	atpase or kinase
HKK59_RS02215	COG1316	TRANSCRIPTIONal
HKK59_RS02225	COG0537	adenosine 5'-monophosphoramidase activity
HKK59_RS02240	COG1131	(ABC) transporter
HKK59_RS02245	COG4473	ABC transporter
HKK59_RS02255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HKK59_RS02270	COG0195	Participates in both transcription termination and antitermination
HKK59_RS02275	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HKK59_RS02285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HKK59_RS02290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HKK59_RS02315	COG2860	membrane
HKK59_RS02325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKK59_RS02325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKK59_RS02330	COG1832	CoA-binding protein
HKK59_RS02350	COG5002	protein histidine kinase activity
HKK59_RS02370	COG1268	BioY protein
HKK59_RS02375	COG1234	tRNA 3'-trailer cleavage
HKK59_RS02390	COG0166	Belongs to the GPI family
HKK59_RS02395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKK59_RS02400	COG0705	Rhomboid family
HKK59_RS02400	COG0457	Tetratricopeptide repeat
HKK59_RS02405	COG1744	ABC transporter substrate-binding protein PnrA-like
HKK59_RS02410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HKK59_RS02425	COG0706	membrane insertase activity
HKK59_RS02485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKK59_RS02495	COG2153	protein acetylation
HKK59_RS02505	COG1216	Glycosyl transferase, family 2
HKK59_RS02505	COG1442	glycosyl transferase family 8
HKK59_RS02555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKK59_RS02565	COG0789	Transcriptional regulator
HKK59_RS02575	COG0656	L-ascorbic acid biosynthetic process
HKK59_RS02620	COG2226	methyltransferase
HKK59_RS02630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK59_RS02635	COG3414	Phosphotransferase system galactitol-specific IIB component
HKK59_RS02640	COG3775	system Galactitol-specific IIC component
HKK59_RS02645	COG0235	Class ii aldolase
HKK59_RS02655	COG3775	system Galactitol-specific IIC component
HKK59_RS02660	COG3414	Phosphotransferase system galactitol-specific IIB component
HKK59_RS02665	COG2207	Transcriptional regulator
HKK59_RS02675	COG1175	transmembrane transport
HKK59_RS02680	COG0395	ABC-type sugar transport system, permease component
HKK59_RS02700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKK59_RS02705	COG2017	converts alpha-aldose to the beta-anomer
HKK59_RS02740	COG0673	inositol 2-dehydrogenase activity
HKK59_RS02750	COG2315	Protein conserved in bacteria
HKK59_RS02765	COG0742	ribosomal rna small subunit methyltransferase
HKK59_RS02780	COG3480	Lon protease (S16) C-terminal proteolytic domain
HKK59_RS02785	COG0737	Belongs to the 5'-nucleotidase family
HKK59_RS02790	COG4470	Protein conserved in bacteria
HKK59_RS02805	COG1132	(ABC) transporter
HKK59_RS02810	COG1132	(ABC) transporter
HKK59_RS02815	COG0512	Glutamine amidotransferase of anthranilate synthase
HKK59_RS02825	COG1268	BioY protein
HKK59_RS02840	COG0183	Belongs to the thiolase family
HKK59_RS02850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKK59_RS02865	COG1940	carbohydrate kinase activity
HKK59_RS02870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK59_RS02910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HKK59_RS02920	COG0762	integral membrane protein
HKK59_RS02925	COG2302	S4 RNA-binding domain
HKK59_RS02930	COG3599	regulation of cell shape
HKK59_RS02945	COG0494	nUDIX hydrolase
HKK59_RS02950	COG0542	response to heat
HKK59_RS02955	COG4703	Protein of unknown function (DUF1797)
HKK59_RS02960	COG0765	amino acid transport
HKK59_RS02965	COG1126	abc transporter atp-binding protein
HKK59_RS02970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKK59_RS02980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HKK59_RS02990	COG1722	exodeoxyribonuclease VII activity
HKK59_RS03000	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HKK59_RS03005	COG1438	arginine binding
HKK59_RS03010	COG0497	DNA recombination
HKK59_RS03015	COG1307	EDD domain protein, DegV family
HKK59_RS03020	COG2755	lipolytic protein G-D-S-L family
HKK59_RS03065	COG1078	dGTPase activity
HKK59_RS03090	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HKK59_RS03100	COG2884	Cell division ATP-binding protein ftsE
HKK59_RS03105	COG2177	Part of the ABC transporter FtsEX involved in
HKK59_RS03130	COG3344	reverse transcriptase
HKK59_RS03135	COG1199	ATP-dependent helicase activity
HKK59_RS03135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKK59_RS03140	COG0436	Aminotransferase
HKK59_RS03145	COG0017	Asparaginyl-tRNA synthetase
HKK59_RS03165	COG1660	Displays ATPase and GTPase activities
HKK59_RS03195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HKK59_RS03205	COG0716	FMN binding
HKK59_RS03210	COG1605	Chorismate mutase
HKK59_RS03210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HKK59_RS03215	COG0038	chloride channel
HKK59_RS03220	COG0335	large ribosomal subunit rRNA binding
HKK59_RS03270	COG1136	(ABC) transporter
HKK59_RS03285	COG5002	protein histidine kinase activity
HKK59_RS03305	COG0772	Belongs to the SEDS family
HKK59_RS03325	COG0560	Phosphoserine phosphatase
HKK59_RS03340	COG0148	phosphopyruvate hydratase activity
HKK59_RS03360	COG1316	TRANSCRIPTIONal
HKK59_RS03410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKK59_RS03410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKK59_RS03460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HKK59_RS03480	COG0270	DNA (cytosine-5-)-methyltransferase activity
HKK59_RS03520	COG4695	Portal protein
HKK59_RS03525	COG0740	serine-type endopeptidase activity
HKK59_RS03590	COG1705	Flagellar rod assembly protein muramidase FlgJ
HKK59_RS03600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HKK59_RS03625	COG3700	Belongs to the class B bacterial acid phosphatase family
HKK59_RS03715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HKK59_RS03720	COG4555	ABC transporter
HKK59_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
HKK59_RS03750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK59_RS03755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HKK59_RS03775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HKK59_RS03780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK59_RS03800	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKK59_RS03800	COG3064	Membrane
HKK59_RS03815	COG3590	peptidase
HKK59_RS03820	COG3590	peptidase
HKK59_RS03855	COG1136	(ABC) transporter
HKK59_RS03870	COG0586	Pfam SNARE associated Golgi protein
HKK59_RS03875	COG4619	ABC transporter
HKK59_RS03880	COG0390	transport system, permease component
HKK59_RS03890	COG0583	DNA-binding transcription factor activity
HKK59_RS03900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK59_RS03905	COG2211	Major facilitator Superfamily
HKK59_RS03915	COG3250	beta-galactosidase activity
HKK59_RS03920	COG2186	Transcriptional regulator
HKK59_RS03925	COG0800	Aldolase
HKK59_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
HKK59_RS03965	COG1609	Transcriptional regulator
HKK59_RS03980	COG0438	transferase activity, transferring glycosyl groups
HKK59_RS04005	COG0765	amino acid transport
HKK59_RS04010	COG0765	amino acid transport
HKK59_RS04015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK59_RS04020	COG1126	abc transporter atp-binding protein
HKK59_RS04025	COG0745	RESPONSE REGULATOR receiver
HKK59_RS04030	COG5002	protein histidine kinase activity
HKK59_RS04035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HKK59_RS04040	COG2832	Protein of unknown function (DUF454)
HKK59_RS04050	COG1196	nuclear chromosome segregation
HKK59_RS04055	COG0561	phosphatase activity
HKK59_RS04060	COG0561	phosphatase activity
HKK59_RS04065	COG0552	protein localization to endoplasmic reticulum
HKK59_RS04070	COG3344	reverse transcriptase
HKK59_RS04075	COG3689	TIGRFAM TIGR03943 family protein
HKK59_RS04080	COG0701	Predicted permease
HKK59_RS04095	COG2183	response to ionizing radiation
HKK59_RS04100	COG3091	SprT-like family
HKK59_RS04105	COG1983	PspC domain protein
HKK59_RS04150	COG4443	Transcriptional Coactivator p15 (PC4)
HKK59_RS04160	COG1914	H( )-stimulated, divalent metal cation uptake system
HKK59_RS04175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKK59_RS04175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKK59_RS04200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKK59_RS04225	COG1164	Oligoendopeptidase f
HKK59_RS04235	COG0772	Belongs to the SEDS family
HKK59_RS04255	COG0768	penicillin binding
HKK59_RS04270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKK59_RS04275	COG2223	nitrite transmembrane transporter activity
HKK59_RS04300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKK59_RS04305	COG2011	ABC-type metal ion transport system permease component
HKK59_RS04310	COG1464	Belongs to the NlpA lipoprotein family
HKK59_RS04315	COG0513	Belongs to the DEAD box helicase family
HKK59_RS04325	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HKK59_RS04330	COG0204	Acyl-transferase
HKK59_RS04340	COG0658	competence protein
HKK59_RS04340	COG2333	competence protein COMEC
HKK59_RS04345	COG0561	phosphatase activity
HKK59_RS04350	COG1609	Transcriptional regulator
HKK59_RS04355	COG0657	acetylesterase activity
HKK59_RS04360	COG2226	methyltransferase
HKK59_RS04370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKK59_RS04375	COG3711	transcriptional antiterminator
HKK59_RS04380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK59_RS04380	COG2190	(PTS) system
HKK59_RS04380	COG1263	PTS System
HKK59_RS04390	COG3835	regulator
HKK59_RS04395	COG1929	Belongs to the glycerate kinase type-1 family
HKK59_RS04400	COG2610	gluconate transmembrane transporter activity
HKK59_RS04410	COG1846	Transcriptional regulator
HKK59_RS04425	COG0363	glucosamine-6-phosphate deaminase activity
HKK59_RS04430	COG0435	Glutathione S-transferase
HKK59_RS04435	COG1187	pseudouridine synthase activity
HKK59_RS04455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HKK59_RS04460	COG4122	O-methyltransferase activity
HKK59_RS04470	COG4894	glucomannan catabolic process
HKK59_RS04480	COG1811	Na channel or pump
HKK59_RS04485	COG1442	glycosyl transferase family 8
HKK59_RS04495	COG1476	TRANSCRIPTIONal
HKK59_RS04510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKK59_RS04515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKK59_RS04520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HKK59_RS04535	COG1012	belongs to the aldehyde dehydrogenase family
HKK59_RS04540	COG0726	polysaccharide deacetylase
HKK59_RS04555	COG1956	GAF domain-containing protein
HKK59_RS04560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKK59_RS04570	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HKK59_RS04570	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HKK59_RS04600	COG4721	ABC-type cobalt transport system, permease component
HKK59_RS04605	COG1122	ATPase activity
HKK59_RS04615	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKK59_RS04645	COG4109	DRTGG domain
HKK59_RS04650	COG0024	Methionine aminopeptidase
HKK59_RS04660	COG2246	polysaccharide biosynthetic process
HKK59_RS04665	COG4708	membrane
HKK59_RS04675	COG1597	lipid kinase activity
HKK59_RS04680	COG1523	belongs to the glycosyl hydrolase 13 family
HKK59_RS04695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HKK59_RS04780	COG2321	neutral zinc metallopeptidase
HKK59_RS04810	COG0488	(ABC) transporter
HKK59_RS04815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HKK59_RS04820	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKK59_RS04820	COG0022	dehydrogenase e1 component
HKK59_RS04825	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKK59_RS04835	COG0095	Lipoate-protein ligase
HKK59_RS04840	COG3344	reverse transcriptase
HKK59_RS04845	COG3442	glutamine amidotransferase
HKK59_RS04850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKK59_RS04855	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HKK59_RS04880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HKK59_RS04890	COG0647	UMP catabolic process
HKK59_RS04900	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HKK59_RS04905	COG1518	maintenance of DNA repeat elements
HKK59_RS04910	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HKK59_RS04925	COG0481	GTPase activity
HKK59_RS04935	COG1418	mRNA catabolic process
HKK59_RS04940	COG0456	acetyltransferase
HKK59_RS04950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKK59_RS04980	COG1131	(ABC) transporter
HKK59_RS04985	COG1725	Transcriptional regulator
HKK59_RS04995	COG0205	6-phosphofructokinase activity
HKK59_RS05000	COG0469	pyruvate kinase activity
HKK59_RS05010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKK59_RS05015	COG2824	Alkylphosphonate utilization operon protein PhnA
HKK59_RS05020	COG0765	amino acid transport
HKK59_RS05025	COG1126	abc transporter atp-binding protein
HKK59_RS05040	COG1072	(Pantothenic acid kinase))
HKK59_RS05045	COG2813	Specifically methylates the guanine in position
HKK59_RS05055	COG1744	ABC transporter substrate-binding protein PnrA-like
HKK59_RS05090	COG3764	Sortase (surface protein transpeptidase)
HKK59_RS05095	COG0346	lactoylglutathione lyase activity
HKK59_RS05120	COG2188	Transcriptional regulator
HKK59_RS05135	COG1464	Belongs to the NlpA lipoprotein family
HKK59_RS05150	COG1136	(ABC) transporter
HKK59_RS05160	COG5002	protein histidine kinase activity
HKK59_RS05165	COG4974	Belongs to the 'phage' integrase family
HKK59_RS05170	COG4166	transmembrane transport
HKK59_RS05185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKK59_RS05190	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HKK59_RS05195	COG5002	protein histidine kinase activity
HKK59_RS05200	COG0745	RESPONSE REGULATOR receiver
HKK59_RS05210	COG0704	Plays a role in the regulation of phosphate uptake
HKK59_RS05215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKK59_RS05220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKK59_RS05225	COG0581	inorganic phosphate transmembrane transporter activity
HKK59_RS05230	COG0573	inorganic phosphate transmembrane transporter activity
HKK59_RS05240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HKK59_RS05240	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HKK59_RS05245	COG0483	inositol monophosphate 1-phosphatase activity
HKK59_RS05260	COG0196	riboflavin kinase activity
HKK59_RS05265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKK59_RS05295	COG1136	(ABC) transporter
HKK59_RS05300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKK59_RS05305	COG0758	DNA mediated transformation
HKK59_RS05310	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HKK59_RS05315	COG4604	ABC transporter, ATP-binding protein
HKK59_RS05320	COG4605	iron ion homeostasis
HKK59_RS05325	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK59_RS05330	COG0110	maltose O-acetyltransferase activity
HKK59_RS05340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HKK59_RS05345	COG1376	ErfK ybiS ycfS ynhG family protein
HKK59_RS05350	COG1966	Carbon starvation protein
HKK59_RS05355	COG3279	Response regulator of the LytR AlgR family
HKK59_RS05360	COG3275	phosphorelay sensor kinase activity
HKK59_RS05470	COG0505	Belongs to the CarA family
HKK59_RS05480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKK59_RS05500	COG0488	(ABC) transporter
HKK59_RS05510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HKK59_RS05520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK59_RS05560	COG0095	Lipoate-protein ligase
HKK59_RS05570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKK59_RS05575	COG4684	Psort location CytoplasmicMembrane, score
HKK59_RS05580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKK59_RS05590	COG1132	(ABC) transporter
HKK59_RS05620	COG2890	protein-(glutamine-N5) methyltransferase activity
HKK59_RS05635	COG1942	4-Oxalocrotonate Tautomerase
HKK59_RS05650	COG1053	succinate dehydrogenase
HKK59_RS05650	COG0431	NADPH-dependent FMN reductase
HKK59_RS05650	COG3976	FMN-binding domain protein
HKK59_RS05660	COG2233	PERMEase
HKK59_RS05675	COG0477	Major facilitator Superfamily
HKK59_RS05690	COG4221	oxidoreductase activity
HKK59_RS05695	COG0280	phosphate acetyltransferase
HKK59_RS05700	COG0564	pseudouridine synthase activity
HKK59_RS05705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKK59_RS05710	COG2357	RelA SpoT domain protein
HKK59_RS05725	COG1104	cysteine desulfurase activity
HKK59_RS05745	COG0628	permease
HKK59_RS05750	COG2723	6-phospho-beta-galactosidase activity
HKK59_RS05760	COG0561	phosphatase activity
HKK59_RS05770	COG0038	chloride channel
HKK59_RS05780	COG1177	transmembrane transport
HKK59_RS05785	COG1176	ABC-type spermidine putrescine transport system, permease component I
HKK59_RS05795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HKK59_RS05800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HKK59_RS05820	COG0285	dihydrofolate synthase activity
HKK59_RS05825	COG2962	Rard protein
HKK59_RS05840	COG0726	polysaccharide deacetylase
HKK59_RS05860	COG1012	belongs to the aldehyde dehydrogenase family
HKK59_RS05935	COG2261	transglycosylase associated protein
HKK59_RS05960	COG1115	amino acid carrier protein
HKK59_RS05965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HKK59_RS05975	COG1346	cytolysis
HKK59_RS05990	COG0539	negative regulation of cytoplasmic translation
HKK59_RS06010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKK59_RS06020	COG0187	DNA topoisomerase II activity
HKK59_RS06025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HKK59_RS06030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HKK59_RS06040	COG2755	lipolytic protein G-D-S-L family
HKK59_RS06040	COG1083	cytidylyl-transferase
HKK59_RS06055	COG2089	acid synthase
HKK59_RS06070	COG1216	Glycosyl transferase, family 2
HKK59_RS06070	COG1442	glycosyl transferase family 8
HKK59_RS06075	COG1442	glycosyl transferase family 8
HKK59_RS06075	COG1216	Glycosyl transferase, family 2
HKK59_RS06090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HKK59_RS06115	COG1316	TRANSCRIPTIONal
HKK59_RS06140	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HKK59_RS06175	COG3842	ATPase activity
HKK59_RS06190	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HKK59_RS06195	COG3527	Alpha-acetolactate decarboxylase
HKK59_RS06200	COG0028	Belongs to the TPP enzyme family
HKK59_RS06205	COG0457	Tetratricopeptide repeat
HKK59_RS06210	COG0628	permease
HKK59_RS06220	COG1051	belongs to the nudix hydrolase family
HKK59_RS06225	COG5492	domain, Protein
HKK59_RS06230	COG1088	dTDP-glucose 4,6-dehydratase activity
HKK59_RS06240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HKK59_RS06245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK59_RS06255	COG2384	SAM-dependent methyltransferase
HKK59_RS06275	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HKK59_RS06275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HKK59_RS06280	COG0300	oxidoreductase activity
HKK59_RS06315	COG1523	belongs to the glycosyl hydrolase 13 family
HKK59_RS06325	COG1573	uracil-dna glycosylase
HKK59_RS06330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKK59_RS06355	COG0534	Mate efflux family protein
HKK59_RS06395	COG0803	Belongs to the bacterial solute-binding protein 9 family
HKK59_RS06415	COG2176	DNA-directed DNA polymerase activity
HKK59_RS06425	COG4974	Belongs to the 'phage' integrase family
HKK59_RS06455	COG1674	ftsk spoiiie
HKK59_RS06495	COG2040	homocysteine
HKK59_RS06500	COG0833	amino acid
HKK59_RS06530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HKK59_RS06540	COG3425	synthase
HKK59_RS06555	COG1272	protein, Hemolysin III
HKK59_RS06600	COG0745	RESPONSE REGULATOR receiver
HKK59_RS06605	COG2357	RelA SpoT domain protein
HKK59_RS06610	COG1132	(ABC) transporter
HKK59_RS06625	COG0737	Belongs to the 5'-nucleotidase family
HKK59_RS06630	COG0242	peptide deformylase activity
HKK59_RS06635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKK59_RS06645	COG1132	(ABC) transporter
HKK59_RS06660	COG0488	(ABC) transporter
HKK59_RS06690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK59_RS06690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKK59_RS06690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKK59_RS06695	COG1105	Belongs to the carbohydrate kinase PfkB family
HKK59_RS06700	COG1349	DNA-binding transcription factor activity
HKK59_RS06705	COG1388	LysM domain
HKK59_RS06705	COG1705	Flagellar rod assembly protein muramidase FlgJ
HKK59_RS06755	COG1837	Belongs to the UPF0109 family
HKK59_RS06760	COG0228	four-way junction DNA binding
HKK59_RS06765	COG0577	efflux transmembrane transporter activity
HKK59_RS06770	COG1136	(ABC) transporter
HKK59_RS06775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKK59_RS06785	COG0505	Belongs to the CarA family
HKK59_RS06795	COG0564	pseudouridine synthase activity
HKK59_RS06805	COG0583	DNA-binding transcription factor activity
HKK59_RS06810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HKK59_RS06835	COG1104	cysteine desulfurase activity
HKK59_RS06845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKK59_RS06870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HKK59_RS06875	COG1368	sulfuric ester hydrolase activity
HKK59_RS06880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HKK59_RS06890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HKK59_RS06920	COG2244	polysaccharide biosynthetic process
HKK59_RS06930	COG1120	ATPase activity
HKK59_RS06935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HKK59_RS06940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK59_RS06945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK59_RS06960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKK59_RS06965	COG1253	flavin adenine dinucleotide binding
HKK59_RS06970	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HKK59_RS06975	COG1242	4 iron, 4 sulfur cluster binding
HKK59_RS06980	COG0671	phosphoesterase, PA-phosphatase related
HKK59_RS06985	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HKK59_RS07015	COG0681	Belongs to the peptidase S26 family
HKK59_RS07025	COG0297	glycogen (starch) synthase activity
HKK59_RS07065	COG3475	LICD family
HKK59_RS07080	COG0463	Glycosyl transferase, family 2
HKK59_RS07085	COG1215	transferase activity, transferring glycosyl groups
HKK59_RS07095	COG1091	dTDP-4-dehydrorhamnose reductase activity
HKK59_RS07100	COG2151	metal-sulfur cluster biosynthetic enzyme
HKK59_RS07105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKK59_RS07110	COG0358	DNA primase activity
HKK59_RS07115	COG1970	mechanosensitive ion channel activity
HKK59_RS07130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK59_RS07135	COG0004	ammonium transporteR
HKK59_RS07155	COG2271	Major facilitator Superfamily
HKK59_RS07160	COG0058	SHG alpha-glucan phosphorylase activity
HKK59_RS07165	COG1640	4-alpha-glucanotransferase
HKK59_RS07170	COG1609	Transcriptional regulator
HKK59_RS07180	COG1175	transmembrane transport
HKK59_RS07185	COG3833	ABC-type maltose transport systems, permease component
HKK59_RS07190	COG3104	oligopeptide transport
HKK59_RS07210	COG0438	transferase activity, transferring glycosyl groups
HKK59_RS07240	COG1442	glycosyl transferase family 8
HKK59_RS07245	COG1442	glycosyl transferase family 8
HKK59_RS07245	COG1216	Glycosyl transferase, family 2
HKK59_RS07250	COG1442	glycosyl transferase family 8
HKK59_RS07255	COG1442	glycosyl transferase family 8
HKK59_RS07255	COG1216	Glycosyl transferase, family 2
HKK59_RS07260	COG1442	glycosyl transferase family 8
HKK59_RS07290	COG0765	amino acid transport
HKK59_RS07295	COG1126	abc transporter atp-binding protein
HKK59_RS07320	COG2309	aminopeptidase activity
HKK59_RS07330	COG0154	amidase activity
HKK59_RS07335	COG1187	pseudouridine synthase activity
HKK59_RS07340	COG0656	L-ascorbic acid biosynthetic process
HKK59_RS07345	COG0778	Nitroreductase
HKK59_RS07350	COG0346	lactoylglutathione lyase activity
HKK59_RS07355	COG0463	Glycosyl transferase, family 2
HKK59_RS07360	COG1113	amino acid transport
HKK59_RS07365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HKK59_RS07370	COG0557	exoribonuclease II activity
HKK59_RS07385	COG2814	Major facilitator Superfamily
HKK59_RS07395	COG1131	(ABC) transporter
HKK59_RS07405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKK59_RS07410	COG1396	sequence-specific DNA binding
HKK59_RS07460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HKK59_RS07465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HKK59_RS07485	COG1702	phosphate starvation-inducible protein PhoH
HKK59_RS07510	COG0233	cytoplasmic translational termination
HKK59_RS07525	COG0444	Belongs to the ABC transporter superfamily
HKK59_RS07530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK59_RS07535	COG0601	transmembrane transport
HKK59_RS07540	COG0747	negative chemotaxis
HKK59_RS07545	COG0081	regulation of translation
HKK59_RS07565	COG1473	amidohydrolase
HKK59_RS07570	COG0583	DNA-binding transcription factor activity
HKK59_RS07585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKK59_RS07590	COG1674	ftsk spoiiie
HKK59_RS07595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKK59_RS07620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKK59_RS07655	COG0673	inositol 2-dehydrogenase activity
HKK59_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
HKK59_RS07725	COG3344	reverse transcriptase
HKK59_RS07730	COG1114	Component of the transport system for branched-chain amino acids
HKK59_RS07735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKK59_RS07735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKK59_RS07750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HKK59_RS07760	COG0708	Exodeoxyribonuclease III
HKK59_RS07765	COG1393	Belongs to the ArsC family
HKK59_RS07770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKK59_RS07775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK59_RS07805	COG0470	DNA polymerase III
HKK59_RS07820	COG0517	IMP dehydrogenase activity
HKK59_RS07840	COG0559	Belongs to the binding-protein-dependent transport system permease family
HKK59_RS07860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HKK59_RS07865	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HKK59_RS07875	COG0531	amino acid
HKK59_RS07880	COG0569	domain protein
HKK59_RS07885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKK59_RS07895	COG1187	pseudouridine synthase activity
HKK59_RS07945	COG1827	regulation of RNA biosynthetic process
HKK59_RS07960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKK59_RS07965	COG1254	Belongs to the acylphosphatase family
HKK59_RS07975	COG0765	amino acid transport
HKK59_RS07980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK59_RS07995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKK59_RS08015	COG3344	reverse transcriptase
HKK59_RS08030	COG1484	DNA-dependent DNA replication
HKK59_RS08045	COG5002	protein histidine kinase activity
HKK59_RS08050	COG0745	RESPONSE REGULATOR receiver
HKK59_RS08065	COG1704	LemA family
HKK59_RS08075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKK59_RS08080	COG0569	domain protein
HKK59_RS08105	COG1114	Component of the transport system for branched-chain amino acids
HKK59_RS08110	COG1063	alcohol dehydrogenase
HKK59_RS08135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK59_RS08140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HKK59_RS08145	COG0217	transcriptional regulatory protein
HKK59_RS08150	COG2376	Dihydroxyacetone kinase
HKK59_RS08155	COG1309	transcriptional regulator
HKK59_RS08160	COG2376	Dihydroxyacetone kinase
HKK59_RS08165	COG1461	Dihydroxyacetone kinase
HKK59_RS08170	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HKK59_RS08175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKK59_RS08185	COG0789	Transcriptional regulator
HKK59_RS08200	COG2226	methyltransferase
HKK59_RS08205	COG0799	negative regulation of ribosome biogenesis
HKK59_RS08215	COG1713	HD superfamily hydrolase involved in NAD metabolism
HKK59_RS08220	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HKK59_RS08225	COG1534	Rna-binding protein
HKK59_RS08230	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HKK59_RS08235	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HKK59_RS08260	COG0574	Belongs to the PEP-utilizing enzyme family
HKK59_RS08260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKK59_RS08270	COG0517	IMP dehydrogenase activity
HKK59_RS08280	COG1335	isochorismatase
HKK59_RS08285	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HKK59_RS08290	COG0436	Aminotransferase
HKK59_RS08295	COG0589	response to stress
HKK59_RS08300	COG0561	phosphatase activity
HKK59_RS08305	COG0252	asparaginase activity
HKK59_RS08315	COG4989	oxidoreductase activity
HKK59_RS08320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKK59_RS08325	COG1705	Flagellar rod assembly protein muramidase FlgJ
HKK59_RS08325	COG3942	CHAP domain
HKK59_RS08335	COG0736	holo-[acyl-carrier-protein] synthase activity
HKK59_RS08340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKK59_RS08350	COG1482	cell wall glycoprotein biosynthetic process
HKK59_RS08355	COG1940	carbohydrate kinase activity
HKK59_RS08360	COG2190	(PTS) system
HKK59_RS08360	COG1263	PTS System
HKK59_RS08360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK59_RS08365	COG1621	beta-fructofuranosidase activity
HKK59_RS08370	COG1609	Transcriptional regulator
HKK59_RS08375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKK59_RS08385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HKK59_RS08415	COG2131	deaminase
HKK59_RS08430	COG2814	Major facilitator Superfamily
HKK59_RS08455	COG0629	single-stranded DNA binding
HKK59_RS08460	COG0360	Binds together with S18 to 16S ribosomal RNA
HKK59_RS08465	COG1194	a g-specific adenine glycosylase
HKK59_RS08475	COG3118	belongs to the thioredoxin family
HKK59_RS08505	COG0681	Belongs to the peptidase S26 family
HKK59_RS08510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKK59_RS08525	COG1882	Formate acetyltransferase
HKK59_RS08530	COG3576	pyridoxamine 5-phosphate
HKK59_RS08535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HKK59_RS08550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKK59_RS08560	COG2814	Major facilitator Superfamily
HKK59_RS08565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKK59_RS08580	COG0142	geranyltranstransferase activity
HKK59_RS08585	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HKK59_RS08590	COG4988	ABC transporter
HKK59_RS08595	COG1294	oxidase, subunit
HKK59_RS08600	COG1271	oxidase subunit
HKK59_RS08605	COG1252	NADH dehydrogenase
HKK59_RS08645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HKK59_RS08650	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HKK59_RS08650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKK59_RS08650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKK59_RS08655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK59_RS08660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKK59_RS08665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK59_RS08665	COG3711	transcriptional antiterminator
HKK59_RS08685	COG4221	oxidoreductase activity
HKK59_RS08720	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HKK59_RS08725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HKK59_RS08730	COG0789	Transcriptional regulator
HKK59_RS08745	COG2081	HI0933 family
HKK59_RS08770	COG0456	acetyltransferase
HKK59_RS08775	COG1214	PFAM Peptidase M22, glycoprotease
HKK59_RS08790	COG3942	CHAP domain
HKK59_RS08795	COG0174	glutamine synthetase
HKK59_RS08800	COG0789	Transcriptional regulator
HKK59_RS08815	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HKK59_RS08840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKK59_RS08865	COG1162	GTPase activity
HKK59_RS08890	COG0084	hydrolase, TatD family'
HKK59_RS08915	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HKK59_RS08920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK59_RS08925	COG1696	Membrane protein involved in D-alanine export
HKK59_RS08945	COG0745	RESPONSE REGULATOR receiver
HKK59_RS08965	COG3448	diguanylate cyclase activity
HKK59_RS08965	COG4175	Glycine betaine
HKK59_RS08970	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HKK59_RS08990	COG1070	Carbohydrate kinase
HKK59_RS09000	COG3775	system Galactitol-specific IIC component
HKK59_RS09005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK59_RS09015	COG1609	Transcriptional regulator
HKK59_RS09100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKK59_RS09105	COG1428	Deoxynucleoside kinase
HKK59_RS09115	COG0542	response to heat
HKK59_RS09120	COG4463	regulation of RNA biosynthetic process
HKK59_RS09130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HKK59_RS09140	COG0450	alkyl hydroperoxide reductase
HKK59_RS09155	COG0025	NhaP-type Na H and K H
HKK59_RS09165	COG1619	proteins homologs of microcin C7 resistance protein MccF
HKK59_RS09170	COG3590	peptidase
HKK59_RS09195	COG1609	Transcriptional regulator
HKK59_RS09220	COG2176	DNA-directed DNA polymerase activity
HKK59_RS09225	COG1388	LysM domain
HKK59_RS09225	COG1705	Flagellar rod assembly protein muramidase FlgJ
HKK59_RS09240	COG4589	Belongs to the CDS family
HKK59_RS09245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKK59_RS09250	COG1862	Preprotein translocase
HKK59_RS09270	COG3493	citrate carrier protein
HKK59_RS09275	COG3290	protein histidine kinase activity
HKK59_RS09280	COG4565	transcriptional regulatory protein
HKK59_RS09285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKK59_RS09295	COG3842	ATPase activity
HKK59_RS09375	COG0737	Belongs to the 5'-nucleotidase family
HKK59_RS09385	COG1363	Peptidase, m42
HKK59_RS09400	COG4753	response regulator
HKK59_RS09400	COG2207	Transcriptional regulator
HKK59_RS09405	COG2972	Histidine kinase
HKK59_RS09410	COG3716	PTS system mannose fructose sorbose family IID component
HKK59_RS09415	COG3715	PTS system
HKK59_RS09445	COG1131	(ABC) transporter
HKK59_RS09455	COG2274	protein secretion by the type I secretion system
HKK59_RS09460	COG3290	protein histidine kinase activity
HKK59_RS09475	COG1263	PTS System
HKK59_RS09475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK59_RS09475	COG2190	(PTS) system
HKK59_RS09480	COG5002	protein histidine kinase activity
HKK59_RS09485	COG0745	RESPONSE REGULATOR receiver
HKK59_RS09500	COG0581	inorganic phosphate transmembrane transporter activity
HKK59_RS09505	COG0573	inorganic phosphate transmembrane transporter activity
HKK59_RS09520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HKK59_RS09535	COG0789	Transcriptional regulator
HKK59_RS09545	COG0494	nUDIX hydrolase
HKK59_RS09560	COG0456	acetyltransferase
HKK59_RS09565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HKK59_RS09590	COG0582	viral genome integration into host DNA
HKK59_RS09600	COG2946	Replication initiation factor
HKK59_RS09620	COG2378	regulation of single-species biofilm formation
HKK59_RS09625	COG0693	protein deglycase activity
HKK59_RS09715	COG1131	(ABC) transporter
HKK59_RS09760	COG1131	(ABC) transporter
HKK59_RS09770	COG1396	sequence-specific DNA binding
HKK59_RS09780	COG1694	Mazg nucleotide pyrophosphohydrolase
HKK59_RS09785	COG1611	Belongs to the LOG family
HKK59_RS09795	COG2897	thiosulfate sulfurtransferase activity
HKK59_RS09810	COG0371	Dehydrogenase
HKK59_RS09820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HKK59_RS09820	COG0646	methionine synthase
HKK59_RS09835	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HKK59_RS09845	COG0745	RESPONSE REGULATOR receiver
HKK59_RS09850	COG2770	Histidine kinase
HKK59_RS09850	COG2205	protein histidine kinase activity
HKK59_RS09865	COG2814	Major facilitator Superfamily
HKK59_RS09870	COG4667	esterase of the alpha-beta hydrolase superfamily
HKK59_RS09895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKK59_RS09900	COG0564	pseudouridine synthase activity
HKK59_RS09920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HKK59_RS09925	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HKK59_RS09945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HKK59_RS09950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKK59_RS09950	COG1116	anion transmembrane transporter activity
HKK59_RS09960	COG0561	phosphatase activity
HKK59_RS09965	COG2514	catechol 2,3-dioxygenase activity
HKK59_RS09975	COG0602	queuosine metabolic process
HKK59_RS09995	COG1328	CTP reductase activity
HKK59_RS10010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKK59_RS10020	COG1393	Belongs to the ArsC family
HKK59_RS10025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HKK59_RS10035	COG2818	Glycosylase
HKK59_RS10080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HKK59_RS10085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HKK59_RS10105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HKK59_RS10110	COG3344	reverse transcriptase
HKK59_RS10165	COG0582	viral genome integration into host DNA
HKK59_RS10175	COG0745	RESPONSE REGULATOR receiver
HKK59_RS10180	COG5002	protein histidine kinase activity
HKK59_RS10185	COG1288	antiporter activity
HKK59_RS10195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HKK59_RS10200	COG3852	Histidine kinase
HKK59_RS10205	COG0784	Response regulator, receiver
HKK59_RS10210	COG1125	glycine betaine transport
HKK59_RS10210	COG0517	IMP dehydrogenase activity
HKK59_RS10215	COG1174	glycine betaine transport
HKK59_RS10220	COG0392	lysyltransferase activity
HKK59_RS10220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HKK59_RS10230	COG3759	membrane
HKK59_RS10345	COG0582	viral genome integration into host DNA
HKK59_RS10360	COG0305	Participates in initiation and elongation during chromosome replication
HKK59_RS10380	COG2095	MarC family integral membrane protein
HKK59_RS10390	COG1760	l-serine dehydratase
HKK59_RS10395	COG1760	l-serine dehydratase
HKK59_RS10400	COG0741	lytic transglycosylase activity
HKK59_RS10425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKK59_RS10430	COG0612	Peptidase, M16
HKK59_RS10435	COG0612	Peptidase, M16
HKK59_RS10440	COG2501	S4 domain
HKK59_RS10460	COG0516	GMP reductase activity
HKK59_RS10460	COG0517	IMP dehydrogenase activity
HKK59_RS10470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKK59_RS10485	COG0454	-acetyltransferase
HKK59_RS10500	COG0549	Belongs to the carbamate kinase family
HKK59_RS10515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HKK59_RS10520	COG0488	(ABC) transporter
HKK59_RS10525	COG4485	Bacterial membrane protein, YfhO
HKK59_RS10545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HKK59_RS10550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKK59_RS10555	COG1475	DNA binding