locus-tag	class	description
GRB95_RS00010	COG0592	DNA-directed DNA polymerase activity
GRB95_RS00030	COG0012	GTP binding
GRB95_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GRB95_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GRB95_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GRB95_RS00260	COG0436	Aminotransferase
GRB95_RS00275	COG0416	fatty acid biosynthetic process
GRB95_RS00280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GRB95_RS00290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GRB95_RS00305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GRB95_RS00315	COG0138	bifunctional purine biosynthesis protein purh
GRB95_RS00340	COG1175	transmembrane transport
GRB95_RS00345	COG0395	ABC-type sugar transport system, permease component
GRB95_RS00360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GRB95_RS00370	COG3458	cephalosporin-C deacetylase activity
GRB95_RS00385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GRB95_RS00405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GRB95_RS00420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GRB95_RS00430	COG2755	lipolytic protein G-D-S-L family
GRB95_RS00430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GRB95_RS00435	COG1012	belongs to the aldehyde dehydrogenase family
GRB95_RS00435	COG1454	alcohol dehydrogenase
GRB95_RS00440	COG1064	alcohol dehydrogenase
GRB95_RS00450	COG0534	Mate efflux family protein
GRB95_RS00560	COG0201	protein transport
GRB95_RS00565	COG0563	adenylate kinase activity
GRB95_RS00580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GRB95_RS00590	COG0202	RNA polymerase activity
GRB95_RS00715	COG1705	Flagellar rod assembly protein muramidase FlgJ
GRB95_RS00720	COG1420	regulation of RNA biosynthetic process
GRB95_RS00730	COG0443	Heat shock 70 kDa protein
GRB95_RS00735	COG0484	heat shock protein binding
GRB95_RS00740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GRB95_RS00745	COG0101	tRNA pseudouridine synthase activity
GRB95_RS00750	COG0351	phosphomethylpyrimidine kinase
GRB95_RS00755	COG4720	Psort location CytoplasmicMembrane, score
GRB95_RS00765	COG0668	transmembrane transport
GRB95_RS00770	COG0544	peptidyl-prolyl cis-trans isomerase activity
GRB95_RS00795	COG0756	dUTP diphosphatase activity
GRB95_RS00810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GRB95_RS00815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GRB95_RS00820	COG1879	ABC-type sugar transport system periplasmic component
GRB95_RS00825	COG1172	Belongs to the binding-protein-dependent transport system permease family
GRB95_RS00830	COG1129	ABC transporter
GRB95_RS00835	COG1869	D-ribose catabolic process
GRB95_RS00840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GRB95_RS00845	COG1609	Transcriptional regulator
GRB95_RS00850	COG0577	efflux transmembrane transporter activity
GRB95_RS00855	COG1136	(ABC) transporter
GRB95_RS00860	COG0745	RESPONSE REGULATOR receiver
GRB95_RS00865	COG2205	protein histidine kinase activity
GRB95_RS00870	COG0137	argininosuccinate synthase activity
GRB95_RS00875	COG0165	Argininosuccinate lyase
GRB95_RS00880	COG0191	fructose-bisphosphate aldolase activity
GRB95_RS00900	COG1461	Dihydroxyacetone kinase
GRB95_RS00915	COG1126	abc transporter atp-binding protein
GRB95_RS00920	COG0765	amino acid transport
GRB95_RS00940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GRB95_RS00950	COG0719	Fe-S assembly protein
GRB95_RS00955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GRB95_RS00965	COG0719	Fe-S assembly protein
GRB95_RS00970	COG1686	Belongs to the peptidase S11 family
GRB95_RS00975	COG1686	Belongs to the peptidase S11 family
GRB95_RS00980	COG4166	transmembrane transport
GRB95_RS00985	COG0601	transmembrane transport
GRB95_RS00990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GRB95_RS00995	COG0444	Belongs to the ABC transporter superfamily
GRB95_RS01000	COG4608	Belongs to the ABC transporter superfamily
GRB95_RS01030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GRB95_RS01040	COG1121	(ABC) transporter
GRB95_RS01045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GRB95_RS01055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GRB95_RS01060	COG4499	WXG100 protein secretion system (Wss), protein YukC
GRB95_RS01060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GRB95_RS01080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GRB95_RS01085	COG1459	type II secretion system
GRB95_RS01115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GRB95_RS01140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GRB95_RS01145	COG1363	Peptidase, m42
GRB95_RS01160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GRB95_RS01165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRB95_RS01175	COG0629	single-stranded DNA binding
GRB95_RS01180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GRB95_RS01200	COG1346	cytolysis
GRB95_RS01210	COG0601	transmembrane transport
GRB95_RS01215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GRB95_RS01220	COG1122	ATPase activity
GRB95_RS01230	COG1263	PTS System
GRB95_RS01230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRB95_RS01235	COG0366	Alpha amylase catalytic
GRB95_RS01240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRB95_RS01255	COG3959	Transketolase, thiamine diphosphate binding domain
GRB95_RS01260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GRB95_RS01265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GRB95_RS01275	COG1185	polyribonucleotide nucleotidyltransferase activity
GRB95_RS01285	COG1045	serine acetyltransferase
GRB95_RS01295	COG0215	cysteine-tRNA ligase activity
GRB95_RS01300	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GRB95_RS01320	COG1476	TRANSCRIPTIONal
GRB95_RS01330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GRB95_RS01340	COG0582	viral genome integration into host DNA
GRB95_RS01385	COG0732	type I restriction modification DNA specificity domain
GRB95_RS01395	COG4974	Belongs to the 'phage' integrase family
GRB95_RS01445	COG1396	sequence-specific DNA binding
GRB95_RS01465	COG1732	Glycine betaine
GRB95_RS01565	COG0519	Catalyzes the synthesis of GMP from XMP
GRB95_RS01610	COG1695	Transcriptional regulator
GRB95_RS01625	COG1755	Isoprenylcysteine carboxyl methyltransferase
GRB95_RS01640	COG0751	glycine-tRNA ligase activity
GRB95_RS01665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GRB95_RS01670	COG0446	pyridine nucleotide-disulphide oxidoreductase
GRB95_RS01690	COG1131	(ABC) transporter
GRB95_RS01700	COG1263	PTS System
GRB95_RS01700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRB95_RS01700	COG2190	(PTS) system
GRB95_RS01705	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GRB95_RS01710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GRB95_RS01715	COG0275	rRNA processing
GRB95_RS01725	COG0768	penicillin binding
GRB95_RS01735	COG0513	Belongs to the DEAD box helicase family
GRB95_RS01750	COG1126	abc transporter atp-binding protein
GRB95_RS01760	COG0492	ferredoxin-NADP+ reductase activity
GRB95_RS01765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GRB95_RS01775	COG3579	cysteine-type endopeptidase activity
GRB95_RS01780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GRB95_RS01805	COG0116	Belongs to the methyltransferase superfamily
GRB95_RS01815	COG1854	S-ribosylhomocysteine lyase activity
GRB95_RS01820	COG4372	Transposase
GRB95_RS01820	COG1418	mRNA catabolic process
GRB95_RS01825	COG1131	(ABC) transporter
GRB95_RS01830	COG4585	Histidine kinase
GRB95_RS01835	COG2197	response regulator
GRB95_RS01845	COG0194	GDP metabolic process
GRB95_RS01855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GRB95_RS01860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GRB95_RS01865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GRB95_RS01865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GRB95_RS01875	COG0515	serine threonine protein kinase
GRB95_RS01875	COG2815	serine threonine protein kinase
GRB95_RS01885	COG4585	Histidine kinase
GRB95_RS01890	COG2197	response regulator
GRB95_RS01900	COG1098	S1 RNA binding domain
GRB95_RS01905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GRB95_RS01910	COG1349	DNA-binding transcription factor activity
GRB95_RS01920	COG1447	Phosphotransferase system cellobiose-specific component IIA
GRB95_RS01930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GRB95_RS01935	COG1882	Formate acetyltransferase
GRB95_RS01955	COG1739	Uncharacterized protein family UPF0029
GRB95_RS01960	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GRB95_RS01965	COG1040	competence protein
GRB95_RS02000	COG0527	aspartate kinase activity
GRB95_RS02005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GRB95_RS02010	COG1024	Enoyl-CoA hydratase
GRB95_RS02020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GRB95_RS02030	COG2070	2-Nitropropane dioxygenase
GRB95_RS02035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GRB95_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
GRB95_RS02045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GRB95_RS02060	COG0439	Biotin carboxylase
GRB95_RS02080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GRB95_RS02095	COG3716	PTS system mannose fructose sorbose family IID component
GRB95_RS02100	COG3715	PTS system
GRB95_RS02110	COG0561	phosphatase activity
GRB95_RS02125	COG2252	PERMEase
GRB95_RS02130	COG0802	atpase or kinase
GRB95_RS02140	COG1316	TRANSCRIPTIONal
GRB95_RS02150	COG0537	adenosine 5'-monophosphoramidase activity
GRB95_RS02165	COG1131	(ABC) transporter
GRB95_RS02170	COG4473	ABC transporter
GRB95_RS02180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GRB95_RS02195	COG0195	Participates in both transcription termination and antitermination
GRB95_RS02200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GRB95_RS02210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GRB95_RS02215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GRB95_RS02240	COG2860	membrane
GRB95_RS02250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GRB95_RS02250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GRB95_RS02255	COG1832	CoA-binding protein
GRB95_RS02275	COG5002	protein histidine kinase activity
GRB95_RS02295	COG1268	BioY protein
GRB95_RS02300	COG1234	tRNA 3'-trailer cleavage
GRB95_RS02315	COG0166	Belongs to the GPI family
GRB95_RS02320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GRB95_RS02325	COG0705	Rhomboid family
GRB95_RS02325	COG0457	Tetratricopeptide repeat
GRB95_RS02330	COG1744	ABC transporter substrate-binding protein PnrA-like
GRB95_RS02335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GRB95_RS02350	COG0706	membrane insertase activity
GRB95_RS02420	COG2137	regulation of response to DNA damage stimulus
GRB95_RS02425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GRB95_RS02445	COG1216	Glycosyl transferase, family 2
GRB95_RS02445	COG1442	glycosyl transferase family 8
GRB95_RS02485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GRB95_RS02495	COG0789	Transcriptional regulator
GRB95_RS02565	COG0525	valine-tRNA ligase activity
GRB95_RS02595	COG2315	Protein conserved in bacteria
GRB95_RS02600	COG2502	aspartate--ammonia ligase
GRB95_RS02610	COG0742	ribosomal rna small subunit methyltransferase
GRB95_RS02625	COG3480	Lon protease (S16) C-terminal proteolytic domain
GRB95_RS02630	COG0737	Belongs to the 5'-nucleotidase family
GRB95_RS02635	COG4470	Protein conserved in bacteria
GRB95_RS02640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GRB95_RS02650	COG1132	(ABC) transporter
GRB95_RS02655	COG1132	(ABC) transporter
GRB95_RS02660	COG0512	Glutamine amidotransferase of anthranilate synthase
GRB95_RS02665	COG1268	BioY protein
GRB95_RS02670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GRB95_RS02690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GRB95_RS02705	COG1940	carbohydrate kinase activity
GRB95_RS02710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GRB95_RS02725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GRB95_RS02750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GRB95_RS02760	COG0762	integral membrane protein
GRB95_RS02765	COG2302	S4 RNA-binding domain
GRB95_RS02770	COG3599	regulation of cell shape
GRB95_RS02775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GRB95_RS02785	COG0494	nUDIX hydrolase
GRB95_RS02790	COG0542	response to heat
GRB95_RS02795	COG4703	Protein of unknown function (DUF1797)
GRB95_RS02800	COG0765	amino acid transport
GRB95_RS02805	COG1126	abc transporter atp-binding protein
GRB95_RS02810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GRB95_RS02820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GRB95_RS02825	COG1570	exodeoxyribonuclease VII activity
GRB95_RS02830	COG1722	exodeoxyribonuclease VII activity
GRB95_RS02840	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GRB95_RS02845	COG1438	arginine binding
GRB95_RS02850	COG0497	DNA recombination
GRB95_RS02855	COG1307	EDD domain protein, DegV family
GRB95_RS02860	COG2755	lipolytic protein G-D-S-L family
GRB95_RS02905	COG1078	dGTPase activity
GRB95_RS02930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GRB95_RS02940	COG2884	Cell division ATP-binding protein ftsE
GRB95_RS02945	COG2177	Part of the ABC transporter FtsEX involved in
GRB95_RS02965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GRB95_RS02965	COG1199	ATP-dependent helicase activity
GRB95_RS02970	COG0436	Aminotransferase
GRB95_RS02975	COG0017	Asparaginyl-tRNA synthetase
GRB95_RS02995	COG1660	Displays ATPase and GTPase activities
GRB95_RS03020	COG0254	rRNA binding
GRB95_RS03025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GRB95_RS03030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GRB95_RS03035	COG0716	FMN binding
GRB95_RS03040	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GRB95_RS03040	COG1605	Chorismate mutase
GRB95_RS03045	COG0038	chloride channel
GRB95_RS03050	COG0335	large ribosomal subunit rRNA binding
GRB95_RS03060	COG0582	viral genome integration into host DNA
GRB95_RS03265	COG1598	PFAM Uncharacterised protein family UPF0150
GRB95_RS03450	COG1136	(ABC) transporter
GRB95_RS03465	COG5002	protein histidine kinase activity
GRB95_RS03485	COG0772	Belongs to the SEDS family
GRB95_RS03505	COG0560	Phosphoserine phosphatase
GRB95_RS03520	COG0148	phosphopyruvate hydratase activity
GRB95_RS03540	COG1316	TRANSCRIPTIONal
GRB95_RS03565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GRB95_RS03570	COG4555	ABC transporter
GRB95_RS03595	COG1028	Short-chain dehydrogenase reductase Sdr
GRB95_RS03600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GRB95_RS03605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GRB95_RS03625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GRB95_RS03630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GRB95_RS03660	COG1136	(ABC) transporter
GRB95_RS03675	COG0586	Pfam SNARE associated Golgi protein
GRB95_RS03680	COG4619	ABC transporter
GRB95_RS03685	COG0390	transport system, permease component
GRB95_RS03695	COG0583	DNA-binding transcription factor activity
GRB95_RS03705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GRB95_RS03720	COG3250	beta-galactosidase activity
GRB95_RS03725	COG2186	Transcriptional regulator
GRB95_RS03730	COG0800	Aldolase
GRB95_RS03735	COG1904	glucuronate isomerase
GRB95_RS03740	COG1312	Catalyzes the dehydration of D-mannonate
GRB95_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
GRB95_RS03765	COG1609	Transcriptional regulator
GRB95_RS03780	COG0438	transferase activity, transferring glycosyl groups
GRB95_RS03805	COG0765	amino acid transport
GRB95_RS03810	COG0765	amino acid transport
GRB95_RS03815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRB95_RS03820	COG1126	abc transporter atp-binding protein
GRB95_RS03825	COG0745	RESPONSE REGULATOR receiver
GRB95_RS03830	COG5002	protein histidine kinase activity
GRB95_RS03835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GRB95_RS03840	COG2832	Protein of unknown function (DUF454)
GRB95_RS03850	COG1196	nuclear chromosome segregation
GRB95_RS03855	COG0561	phosphatase activity
GRB95_RS03860	COG0561	phosphatase activity
GRB95_RS03865	COG0552	protein localization to endoplasmic reticulum
GRB95_RS03870	COG3689	TIGRFAM TIGR03943 family protein
GRB95_RS03875	COG0701	Predicted permease
GRB95_RS03890	COG2183	response to ionizing radiation
GRB95_RS03895	COG3091	SprT-like family
GRB95_RS03900	COG1983	PspC domain protein
GRB95_RS03940	COG4443	Transcriptional Coactivator p15 (PC4)
GRB95_RS03950	COG1914	H( )-stimulated, divalent metal cation uptake system
GRB95_RS03965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GRB95_RS03965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GRB95_RS03990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GRB95_RS04015	COG1164	Oligoendopeptidase f
GRB95_RS04025	COG0772	Belongs to the SEDS family
GRB95_RS04045	COG0768	penicillin binding
GRB95_RS04060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GRB95_RS04065	COG2223	nitrite transmembrane transporter activity
GRB95_RS04090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GRB95_RS04095	COG2011	ABC-type metal ion transport system permease component
GRB95_RS04100	COG1464	Belongs to the NlpA lipoprotein family
GRB95_RS04105	COG0513	Belongs to the DEAD box helicase family
GRB95_RS04115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GRB95_RS04120	COG0204	Acyl-transferase
GRB95_RS04125	COG1596	polysaccharide export
GRB95_RS04125	COG1555	photosystem II stabilization
GRB95_RS04130	COG0658	competence protein
GRB95_RS04130	COG2333	competence protein COMEC
GRB95_RS04135	COG0561	phosphatase activity
GRB95_RS04140	COG1609	Transcriptional regulator
GRB95_RS04145	COG0657	acetylesterase activity
GRB95_RS04150	COG2226	methyltransferase
GRB95_RS04160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GRB95_RS04165	COG3711	transcriptional antiterminator
GRB95_RS04170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRB95_RS04170	COG2190	(PTS) system
GRB95_RS04170	COG1263	PTS System
GRB95_RS04180	COG3835	regulator
GRB95_RS04185	COG1929	Belongs to the glycerate kinase type-1 family
GRB95_RS04190	COG2610	gluconate transmembrane transporter activity
GRB95_RS04200	COG1846	Transcriptional regulator
GRB95_RS04205	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GRB95_RS04215	COG0363	glucosamine-6-phosphate deaminase activity
GRB95_RS04220	COG0435	Glutathione S-transferase
GRB95_RS04225	COG1187	pseudouridine synthase activity
GRB95_RS04240	COG1164	Oligoendopeptidase f
GRB95_RS04245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GRB95_RS04250	COG4122	O-methyltransferase activity
GRB95_RS04255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GRB95_RS04260	COG4894	glucomannan catabolic process
GRB95_RS04265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GRB95_RS04275	COG1442	glycosyl transferase family 8
GRB95_RS04285	COG1476	TRANSCRIPTIONal
GRB95_RS04300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GRB95_RS04305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GRB95_RS04310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GRB95_RS04325	COG1012	belongs to the aldehyde dehydrogenase family
GRB95_RS04330	COG0726	polysaccharide deacetylase
GRB95_RS04335	COG0513	Belongs to the DEAD box helicase family
GRB95_RS04345	COG1956	GAF domain-containing protein
GRB95_RS04350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GRB95_RS04360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GRB95_RS04360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GRB95_RS04365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GRB95_RS04390	COG4721	ABC-type cobalt transport system, permease component
GRB95_RS04395	COG1122	ATPase activity
GRB95_RS04405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GRB95_RS04415	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GRB95_RS04420	COG0352	thiamine-phosphate diphosphorylase activity
GRB95_RS04425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GRB95_RS04435	COG4109	DRTGG domain
GRB95_RS04440	COG0024	Methionine aminopeptidase
GRB95_RS04450	COG2246	polysaccharide biosynthetic process
GRB95_RS04455	COG4708	membrane
GRB95_RS04460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GRB95_RS04465	COG1597	lipid kinase activity
GRB95_RS04470	COG1523	belongs to the glycosyl hydrolase 13 family
GRB95_RS04475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GRB95_RS04480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GRB95_RS04485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GRB95_RS04490	COG0297	glycogen (starch) synthase activity
GRB95_RS04500	COG0356	it plays a direct role in the translocation of protons across the membrane
GRB95_RS04520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GRB95_RS04530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GRB95_RS04540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GRB95_RS04555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GRB95_RS04565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRB95_RS04565	COG0072	phenylalanine-tRNA ligase activity
GRB95_RS04570	COG2321	neutral zinc metallopeptidase
GRB95_RS04575	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GRB95_RS04580	COG1074	ATP-dependent DNA helicase activity
GRB95_RS04590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GRB95_RS04595	COG0488	(ABC) transporter
GRB95_RS04600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GRB95_RS04605	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRB95_RS04605	COG0022	dehydrogenase e1 component
GRB95_RS04610	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRB95_RS04620	COG0095	Lipoate-protein ligase
GRB95_RS04625	COG3442	glutamine amidotransferase
GRB95_RS04630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GRB95_RS04635	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GRB95_RS04660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GRB95_RS04670	COG0647	UMP catabolic process
GRB95_RS04680	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
GRB95_RS04685	COG1518	maintenance of DNA repeat elements
GRB95_RS04690	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GRB95_RS04715	COG0481	GTPase activity
GRB95_RS04725	COG1418	mRNA catabolic process
GRB95_RS04730	COG0456	acetyltransferase
GRB95_RS04740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GRB95_RS04770	COG1131	(ABC) transporter
GRB95_RS04775	COG1725	Transcriptional regulator
GRB95_RS04785	COG0205	6-phosphofructokinase activity
GRB95_RS04790	COG0469	pyruvate kinase activity
GRB95_RS04800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GRB95_RS04805	COG2824	Alkylphosphonate utilization operon protein PhnA
GRB95_RS04810	COG0765	amino acid transport
GRB95_RS04815	COG1126	abc transporter atp-binding protein
GRB95_RS04830	COG1072	(Pantothenic acid kinase))
GRB95_RS04835	COG2813	Specifically methylates the guanine in position
GRB95_RS04845	COG1744	ABC transporter substrate-binding protein PnrA-like
GRB95_RS04880	COG3764	Sortase (surface protein transpeptidase)
GRB95_RS04885	COG0346	lactoylglutathione lyase activity
GRB95_RS04905	COG2188	Transcriptional regulator
GRB95_RS04910	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GRB95_RS04920	COG1464	Belongs to the NlpA lipoprotein family
GRB95_RS04935	COG1136	(ABC) transporter
GRB95_RS04945	COG0745	RESPONSE REGULATOR receiver
GRB95_RS04950	COG5002	protein histidine kinase activity
GRB95_RS04955	COG4974	Belongs to the 'phage' integrase family
GRB95_RS04975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GRB95_RS04980	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GRB95_RS04985	COG5002	protein histidine kinase activity
GRB95_RS04990	COG0745	RESPONSE REGULATOR receiver
GRB95_RS05000	COG0704	Plays a role in the regulation of phosphate uptake
GRB95_RS05005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GRB95_RS05010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GRB95_RS05015	COG0581	inorganic phosphate transmembrane transporter activity
GRB95_RS05020	COG0573	inorganic phosphate transmembrane transporter activity
GRB95_RS05030	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GRB95_RS05030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GRB95_RS05035	COG0483	inositol monophosphate 1-phosphatase activity
GRB95_RS05040	COG4476	Belongs to the UPF0223 family
GRB95_RS05050	COG0196	riboflavin kinase activity
GRB95_RS05055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GRB95_RS05085	COG1136	(ABC) transporter
GRB95_RS05090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GRB95_RS05095	COG0758	DNA mediated transformation
GRB95_RS05100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GRB95_RS05105	COG4604	ABC transporter, ATP-binding protein
GRB95_RS05110	COG4605	iron ion homeostasis
GRB95_RS05115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRB95_RS05120	COG0110	maltose O-acetyltransferase activity
GRB95_RS05130	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GRB95_RS05135	COG1376	ErfK ybiS ycfS ynhG family protein
GRB95_RS05140	COG1966	Carbon starvation protein
GRB95_RS05145	COG3279	Response regulator of the LytR AlgR family
GRB95_RS05150	COG3275	phosphorelay sensor kinase activity
GRB95_RS05290	COG0505	Belongs to the CarA family
GRB95_RS05300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GRB95_RS05305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GRB95_RS05320	COG0488	(ABC) transporter
GRB95_RS05330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GRB95_RS05340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GRB95_RS05390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GRB95_RS05395	COG4684	Psort location CytoplasmicMembrane, score
GRB95_RS05400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GRB95_RS05410	COG1132	(ABC) transporter
GRB95_RS05440	COG2890	protein-(glutamine-N5) methyltransferase activity
GRB95_RS05445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GRB95_RS05455	COG1942	4-Oxalocrotonate Tautomerase
GRB95_RS05470	COG3976	FMN-binding domain protein
GRB95_RS05470	COG1053	succinate dehydrogenase
GRB95_RS05470	COG0431	NADPH-dependent FMN reductase
GRB95_RS05480	COG2233	PERMEase
GRB95_RS05495	COG0477	Major facilitator Superfamily
GRB95_RS05510	COG4221	oxidoreductase activity
GRB95_RS05515	COG0280	phosphate acetyltransferase
GRB95_RS05520	COG0564	pseudouridine synthase activity
GRB95_RS05530	COG2357	RelA SpoT domain protein
GRB95_RS05545	COG1104	cysteine desulfurase activity
GRB95_RS05565	COG0628	permease
GRB95_RS05570	COG2723	6-phospho-beta-galactosidase activity
GRB95_RS05580	COG0561	phosphatase activity
GRB95_RS05595	COG0038	chloride channel
GRB95_RS05605	COG1177	transmembrane transport
GRB95_RS05610	COG1176	ABC-type spermidine putrescine transport system, permease component I
GRB95_RS05620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GRB95_RS05625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GRB95_RS05645	COG0285	dihydrofolate synthase activity
GRB95_RS05650	COG2962	Rard protein
GRB95_RS05665	COG0726	polysaccharide deacetylase
GRB95_RS05685	COG1012	belongs to the aldehyde dehydrogenase family
GRB95_RS05760	COG2261	transglycosylase associated protein
GRB95_RS05785	COG1115	amino acid carrier protein
GRB95_RS05790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GRB95_RS05800	COG1346	cytolysis
GRB95_RS05815	COG0539	negative regulation of cytoplasmic translation
GRB95_RS05835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GRB95_RS05845	COG0187	DNA topoisomerase II activity
GRB95_RS05850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GRB95_RS05855	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GRB95_RS05865	COG1083	cytidylyl-transferase
GRB95_RS05865	COG2755	lipolytic protein G-D-S-L family
GRB95_RS05880	COG2089	acid synthase
GRB95_RS05895	COG1442	glycosyl transferase family 8
GRB95_RS05895	COG1216	Glycosyl transferase, family 2
GRB95_RS05900	COG1216	Glycosyl transferase, family 2
GRB95_RS05900	COG1442	glycosyl transferase family 8
GRB95_RS05915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GRB95_RS05940	COG1316	TRANSCRIPTIONal
GRB95_RS05965	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GRB95_RS05980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GRB95_RS06015	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GRB95_RS06020	COG3527	Alpha-acetolactate decarboxylase
GRB95_RS06025	COG0028	Belongs to the TPP enzyme family
GRB95_RS06030	COG0457	Tetratricopeptide repeat
GRB95_RS06035	COG0628	permease
GRB95_RS06045	COG1051	belongs to the nudix hydrolase family
GRB95_RS06050	COG5492	domain, Protein
GRB95_RS06055	COG1088	dTDP-glucose 4,6-dehydratase activity
GRB95_RS06060	COG0135	phosphoribosylanthranilate isomerase activity
GRB95_RS06070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GRB95_RS06075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GRB95_RS06085	COG2384	SAM-dependent methyltransferase
GRB95_RS06105	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GRB95_RS06105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GRB95_RS06110	COG0300	oxidoreductase activity
GRB95_RS06155	COG1573	uracil-dna glycosylase
GRB95_RS06160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GRB95_RS06170	COG0584	glycerophosphoryl diester phosphodiesterase
GRB95_RS06175	COG0322	excinuclease ABC activity
GRB95_RS06185	COG0534	Mate efflux family protein
GRB95_RS06225	COG0803	Belongs to the bacterial solute-binding protein 9 family
GRB95_RS06245	COG2176	DNA-directed DNA polymerase activity
GRB95_RS06275	COG2040	homocysteine
GRB95_RS06280	COG0833	amino acid
GRB95_RS06310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GRB95_RS06320	COG3425	synthase
GRB95_RS06335	COG1272	protein, Hemolysin III
GRB95_RS06380	COG0745	RESPONSE REGULATOR receiver
GRB95_RS06385	COG2357	RelA SpoT domain protein
GRB95_RS06390	COG1132	(ABC) transporter
GRB95_RS06405	COG0737	Belongs to the 5'-nucleotidase family
GRB95_RS06410	COG0242	peptide deformylase activity
GRB95_RS06415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GRB95_RS06425	COG1132	(ABC) transporter
GRB95_RS06440	COG0488	(ABC) transporter
GRB95_RS06475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRB95_RS06475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRB95_RS06475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRB95_RS06480	COG1105	Belongs to the carbohydrate kinase PfkB family
GRB95_RS06485	COG1349	DNA-binding transcription factor activity
GRB95_RS06490	COG1705	Flagellar rod assembly protein muramidase FlgJ
GRB95_RS06490	COG1388	LysM domain
GRB95_RS06540	COG1837	Belongs to the UPF0109 family
GRB95_RS06545	COG0228	four-way junction DNA binding
GRB95_RS06550	COG0577	efflux transmembrane transporter activity
GRB95_RS06555	COG1136	(ABC) transporter
GRB95_RS06560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GRB95_RS06570	COG0505	Belongs to the CarA family
GRB95_RS06580	COG0564	pseudouridine synthase activity
GRB95_RS06590	COG0583	DNA-binding transcription factor activity
GRB95_RS06595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GRB95_RS06620	COG1104	cysteine desulfurase activity
GRB95_RS06630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GRB95_RS06635	COG3679	Belongs to the UPF0342 family
GRB95_RS06640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GRB95_RS06645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GRB95_RS06655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GRB95_RS06660	COG1368	sulfuric ester hydrolase activity
GRB95_RS06665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GRB95_RS06675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GRB95_RS06680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GRB95_RS06700	COG2195	Cleaves the N-terminal amino acid of tripeptides
GRB95_RS06705	COG2244	polysaccharide biosynthetic process
GRB95_RS06710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GRB95_RS06715	COG1120	ATPase activity
GRB95_RS06720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRB95_RS06725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRB95_RS06730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRB95_RS06740	COG1227	inorganic diphosphatase activity
GRB95_RS06745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GRB95_RS06750	COG1253	flavin adenine dinucleotide binding
GRB95_RS06755	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GRB95_RS06760	COG1242	4 iron, 4 sulfur cluster binding
GRB95_RS06765	COG0671	phosphoesterase, PA-phosphatase related
GRB95_RS06770	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GRB95_RS06805	COG0297	glycogen (starch) synthase activity
GRB95_RS06845	COG3475	LICD family
GRB95_RS06860	COG0463	Glycosyl transferase, family 2
GRB95_RS06865	COG1215	transferase activity, transferring glycosyl groups
GRB95_RS06875	COG1091	dTDP-4-dehydrorhamnose reductase activity
GRB95_RS06880	COG2151	metal-sulfur cluster biosynthetic enzyme
GRB95_RS06885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GRB95_RS06890	COG0358	DNA primase activity
GRB95_RS06895	COG1970	mechanosensitive ion channel activity
GRB95_RS06910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRB95_RS06920	COG0004	ammonium transporteR
GRB95_RS06940	COG2271	Major facilitator Superfamily
GRB95_RS06945	COG0058	SHG alpha-glucan phosphorylase activity
GRB95_RS06950	COG1640	4-alpha-glucanotransferase
GRB95_RS06955	COG1609	Transcriptional regulator
GRB95_RS06965	COG1175	transmembrane transport
GRB95_RS06970	COG3833	ABC-type maltose transport systems, permease component
GRB95_RS06975	COG3104	oligopeptide transport
GRB95_RS06995	COG0438	transferase activity, transferring glycosyl groups
GRB95_RS07000	COG0653	protein targeting
GRB95_RS07020	COG0201	protein transport
GRB95_RS07025	COG1442	glycosyl transferase family 8
GRB95_RS07030	COG1216	Glycosyl transferase, family 2
GRB95_RS07030	COG1442	glycosyl transferase family 8
GRB95_RS07035	COG1442	glycosyl transferase family 8
GRB95_RS07040	COG1442	glycosyl transferase family 8
GRB95_RS07040	COG1216	Glycosyl transferase, family 2
GRB95_RS07045	COG1442	glycosyl transferase family 8
GRB95_RS07075	COG0765	amino acid transport
GRB95_RS07080	COG1126	abc transporter atp-binding protein
GRB95_RS07105	COG2309	aminopeptidase activity
GRB95_RS07115	COG0154	amidase activity
GRB95_RS07120	COG1187	pseudouridine synthase activity
GRB95_RS07125	COG0656	L-ascorbic acid biosynthetic process
GRB95_RS07130	COG0778	Nitroreductase
GRB95_RS07135	COG0346	lactoylglutathione lyase activity
GRB95_RS07140	COG0463	Glycosyl transferase, family 2
GRB95_RS07145	COG1113	amino acid transport
GRB95_RS07150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GRB95_RS07155	COG0557	exoribonuclease II activity
GRB95_RS07170	COG2814	Major facilitator Superfamily
GRB95_RS07180	COG1131	(ABC) transporter
GRB95_RS07185	COG0237	dephospho-CoA kinase activity
GRB95_RS07190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GRB95_RS07195	COG1396	sequence-specific DNA binding
GRB95_RS07245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GRB95_RS07250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GRB95_RS07270	COG1702	phosphate starvation-inducible protein PhoH
GRB95_RS07285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GRB95_RS07295	COG0233	cytoplasmic translational termination
GRB95_RS07310	COG0444	Belongs to the ABC transporter superfamily
GRB95_RS07315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GRB95_RS07320	COG0601	transmembrane transport
GRB95_RS07325	COG0747	negative chemotaxis
GRB95_RS07330	COG0081	regulation of translation
GRB95_RS07335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GRB95_RS07345	COG1473	amidohydrolase
GRB95_RS07350	COG0583	DNA-binding transcription factor activity
GRB95_RS07360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GRB95_RS07365	COG1674	ftsk spoiiie
GRB95_RS07370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GRB95_RS07395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GRB95_RS07425	COG0673	inositol 2-dehydrogenase activity
GRB95_RS07440	COG1028	Short-chain dehydrogenase reductase Sdr
GRB95_RS07490	COG1114	Component of the transport system for branched-chain amino acids
GRB95_RS07495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRB95_RS07495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRB95_RS07510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GRB95_RS07520	COG0708	Exodeoxyribonuclease III
GRB95_RS07525	COG1393	Belongs to the ArsC family
GRB95_RS07530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GRB95_RS07535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GRB95_RS07545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GRB95_RS07565	COG0470	DNA polymerase III
GRB95_RS07575	COG0517	IMP dehydrogenase activity
GRB95_RS07615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GRB95_RS07620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GRB95_RS07630	COG0531	amino acid
GRB95_RS07635	COG0569	domain protein
GRB95_RS07650	COG1187	pseudouridine synthase activity
GRB95_RS07660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GRB95_RS07665	COG0582	viral genome integration into host DNA
GRB95_RS07685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GRB95_RS07700	COG1827	regulation of RNA biosynthetic process
GRB95_RS07715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GRB95_RS07720	COG1254	Belongs to the acylphosphatase family
GRB95_RS07725	COG0706	membrane insertase activity
GRB95_RS07730	COG0765	amino acid transport
GRB95_RS07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRB95_RS07750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GRB95_RS07760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GRB95_RS07780	COG1484	DNA-dependent DNA replication
GRB95_RS07795	COG5002	protein histidine kinase activity
GRB95_RS07800	COG0745	RESPONSE REGULATOR receiver
GRB95_RS07810	COG0501	Belongs to the peptidase M48B family
GRB95_RS07815	COG1704	LemA family
GRB95_RS07820	COG0357	Ribosomal RNA small subunit methyltransferase G
GRB95_RS07825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GRB95_RS07830	COG0569	domain protein
GRB95_RS07840	COG1122	ATPase activity
GRB95_RS07850	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GRB95_RS07855	COG1114	Component of the transport system for branched-chain amino acids
GRB95_RS07860	COG1063	alcohol dehydrogenase
GRB95_RS07885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRB95_RS07890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GRB95_RS07895	COG0217	transcriptional regulatory protein
GRB95_RS07900	COG2376	Dihydroxyacetone kinase
GRB95_RS07905	COG1309	transcriptional regulator
GRB95_RS07910	COG2376	Dihydroxyacetone kinase
GRB95_RS07915	COG1461	Dihydroxyacetone kinase
GRB95_RS07920	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GRB95_RS07925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GRB95_RS07935	COG0789	Transcriptional regulator
GRB95_RS07940	COG1323	Belongs to the UPF0348 family
GRB95_RS07950	COG2226	methyltransferase
GRB95_RS07955	COG0799	negative regulation of ribosome biogenesis
GRB95_RS07965	COG1713	HD superfamily hydrolase involved in NAD metabolism
GRB95_RS07970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GRB95_RS07975	COG1534	Rna-binding protein
GRB95_RS07980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GRB95_RS07985	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GRB95_RS07995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GRB95_RS08000	COG0154	amidase activity
GRB95_RS08005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GRB95_RS08010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GRB95_RS08010	COG0574	Belongs to the PEP-utilizing enzyme family
GRB95_RS08015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GRB95_RS08020	COG0517	IMP dehydrogenase activity
GRB95_RS08030	COG1335	isochorismatase
GRB95_RS08035	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GRB95_RS08040	COG0436	Aminotransferase
GRB95_RS08045	COG0589	response to stress
GRB95_RS08050	COG0561	phosphatase activity
GRB95_RS08055	COG0252	asparaginase activity
GRB95_RS08065	COG4989	oxidoreductase activity
GRB95_RS08070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GRB95_RS08075	COG3942	CHAP domain
GRB95_RS08075	COG1705	Flagellar rod assembly protein muramidase FlgJ
GRB95_RS08085	COG0736	holo-[acyl-carrier-protein] synthase activity
GRB95_RS08090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GRB95_RS08100	COG1482	cell wall glycoprotein biosynthetic process
GRB95_RS08105	COG1940	carbohydrate kinase activity
GRB95_RS08110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRB95_RS08110	COG2190	(PTS) system
GRB95_RS08110	COG1263	PTS System
GRB95_RS08115	COG1621	beta-fructofuranosidase activity
GRB95_RS08120	COG1609	Transcriptional regulator
GRB95_RS08125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GRB95_RS08135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GRB95_RS08140	COG1132	(ABC) transporter
GRB95_RS08150	COG1129	ABC transporter
GRB95_RS08180	COG1021	2,3-dihydroxybenzoate-AMP ligase
GRB95_RS08190	COG2131	deaminase
GRB95_RS08195	COG0006	proline dipeptidase activity
GRB95_RS08205	COG2814	Major facilitator Superfamily
GRB95_RS08230	COG0629	single-stranded DNA binding
GRB95_RS08235	COG0360	Binds together with S18 to 16S ribosomal RNA
GRB95_RS08240	COG1194	a g-specific adenine glycosylase
GRB95_RS08250	COG3118	belongs to the thioredoxin family
GRB95_RS08260	COG1193	negative regulation of DNA recombination
GRB95_RS08275	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GRB95_RS08280	COG0681	Belongs to the peptidase S26 family
GRB95_RS08285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GRB95_RS08300	COG1882	Formate acetyltransferase
GRB95_RS08305	COG3576	pyridoxamine 5-phosphate
GRB95_RS08310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GRB95_RS08325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GRB95_RS08335	COG2814	Major facilitator Superfamily
GRB95_RS08340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GRB95_RS08345	COG2936	dipeptidyl-peptidase activity
GRB95_RS08355	COG0142	geranyltranstransferase activity
GRB95_RS08360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GRB95_RS08365	COG4988	ABC transporter
GRB95_RS08370	COG1294	oxidase, subunit
GRB95_RS08375	COG1271	oxidase subunit
GRB95_RS08380	COG1252	NADH dehydrogenase
GRB95_RS08400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GRB95_RS08405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GRB95_RS08410	COG0789	Transcriptional regulator
GRB95_RS08425	COG2081	HI0933 family
GRB95_RS08445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GRB95_RS08450	COG0456	acetyltransferase
GRB95_RS08455	COG1214	PFAM Peptidase M22, glycoprotease
GRB95_RS08470	COG3942	CHAP domain
GRB95_RS08475	COG0174	glutamine synthetase
GRB95_RS08480	COG0789	Transcriptional regulator
GRB95_RS08490	COG0126	phosphoglycerate kinase activity
GRB95_RS08495	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GRB95_RS08505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GRB95_RS08520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GRB95_RS08545	COG1162	GTPase activity
GRB95_RS08555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GRB95_RS08570	COG0084	hydrolase, TatD family'
GRB95_RS08595	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GRB95_RS08600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GRB95_RS08605	COG1696	Membrane protein involved in D-alanine export
GRB95_RS08620	COG5002	protein histidine kinase activity
GRB95_RS08645	COG3448	diguanylate cyclase activity
GRB95_RS08645	COG4175	Glycine betaine
GRB95_RS08650	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GRB95_RS08670	COG1070	Carbohydrate kinase
GRB95_RS08680	COG3775	system Galactitol-specific IIC component
GRB95_RS08685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GRB95_RS08695	COG1609	Transcriptional regulator
GRB95_RS08745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GRB95_RS08775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GRB95_RS08780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GRB95_RS08785	COG1428	Deoxynucleoside kinase
GRB95_RS08795	COG0542	response to heat
GRB95_RS08800	COG4463	regulation of RNA biosynthetic process
GRB95_RS08810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GRB95_RS08820	COG0450	alkyl hydroperoxide reductase
GRB95_RS08835	COG0025	NhaP-type Na H and K H
GRB95_RS08845	COG1619	proteins homologs of microcin C7 resistance protein MccF
GRB95_RS08850	COG3590	peptidase
GRB95_RS08875	COG1609	Transcriptional regulator
GRB95_RS08885	COG3716	PTS system mannose fructose sorbose family IID component
GRB95_RS08890	COG3715	PTS system
GRB95_RS08895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRB95_RS08900	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GRB95_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
GRB95_RS08945	COG2176	DNA-directed DNA polymerase activity
GRB95_RS08950	COG1705	Flagellar rod assembly protein muramidase FlgJ
GRB95_RS08950	COG1388	LysM domain
GRB95_RS08965	COG4589	Belongs to the CDS family
GRB95_RS08970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GRB95_RS08975	COG1862	Preprotein translocase
GRB95_RS08990	COG3493	citrate carrier protein
GRB95_RS08995	COG3290	protein histidine kinase activity
GRB95_RS09000	COG4565	transcriptional regulatory protein
GRB95_RS09005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GRB95_RS09015	COG3842	ATPase activity
GRB95_RS09085	COG1490	D-aminoacyl-tRNA deacylase activity
GRB95_RS09140	COG0791	NLP P60 protein
GRB95_RS09140	COG0741	lytic transglycosylase activity
GRB95_RS09170	COG2946	Replication initiation factor
GRB95_RS09180	COG1674	ftsk spoiiie
GRB95_RS09195	COG0737	Belongs to the 5'-nucleotidase family
GRB95_RS09205	COG1363	Peptidase, m42
GRB95_RS09220	COG2207	Transcriptional regulator
GRB95_RS09220	COG4753	response regulator
GRB95_RS09225	COG2972	Histidine kinase
GRB95_RS09230	COG3716	PTS system mannose fructose sorbose family IID component
GRB95_RS09235	COG3715	PTS system
GRB95_RS09260	COG1131	(ABC) transporter
GRB95_RS09270	COG3279	Response regulator of the LytR AlgR family
GRB95_RS09280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRB95_RS09280	COG1263	PTS System
GRB95_RS09280	COG2190	(PTS) system
GRB95_RS09285	COG5002	protein histidine kinase activity
GRB95_RS09290	COG0745	RESPONSE REGULATOR receiver
GRB95_RS09300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GRB95_RS09305	COG0581	inorganic phosphate transmembrane transporter activity
GRB95_RS09310	COG0573	inorganic phosphate transmembrane transporter activity
GRB95_RS09325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GRB95_RS09340	COG0789	Transcriptional regulator
GRB95_RS09360	COG0456	acetyltransferase
GRB95_RS09365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GRB95_RS09375	COG0582	viral genome integration into host DNA
GRB95_RS09435	COG0433	COG0433 Predicted ATPase
GRB95_RS09455	COG4115	mRNA cleavage
GRB95_RS09500	COG1674	ftsk spoiiie
GRB95_RS09545	COG1396	sequence-specific DNA binding
GRB95_RS09595	COG1914	H( )-stimulated, divalent metal cation uptake system
GRB95_RS09605	COG1131	(ABC) transporter
GRB95_RS09645	COG1131	(ABC) transporter
GRB95_RS09655	COG1396	sequence-specific DNA binding
GRB95_RS09665	COG1694	Mazg nucleotide pyrophosphohydrolase
GRB95_RS09695	COG0371	Dehydrogenase
GRB95_RS09705	COG0646	methionine synthase
GRB95_RS09705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GRB95_RS09710	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GRB95_RS09720	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GRB95_RS09730	COG0745	RESPONSE REGULATOR receiver
GRB95_RS09735	COG2770	Histidine kinase
GRB95_RS09735	COG2205	protein histidine kinase activity
GRB95_RS09745	COG0495	leucyl-tRNA aminoacylation
GRB95_RS09750	COG2814	Major facilitator Superfamily
GRB95_RS09755	COG4667	esterase of the alpha-beta hydrolase superfamily
GRB95_RS09760	COG1442	glycosyl transferase family 8
GRB95_RS09765	COG1442	glycosyl transferase family 8
GRB95_RS09790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GRB95_RS09795	COG0564	pseudouridine synthase activity
GRB95_RS09815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GRB95_RS09820	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GRB95_RS09840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GRB95_RS09845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GRB95_RS09845	COG1116	anion transmembrane transporter activity
GRB95_RS09855	COG0561	phosphatase activity
GRB95_RS09860	COG2514	catechol 2,3-dioxygenase activity
GRB95_RS09870	COG0602	queuosine metabolic process
GRB95_RS09890	COG1328	CTP reductase activity
GRB95_RS09905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GRB95_RS09915	COG1393	Belongs to the ArsC family
GRB95_RS09920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GRB95_RS09930	COG2818	Glycosylase
GRB95_RS09945	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GRB95_RS09975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GRB95_RS09980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GRB95_RS09990	COG0124	histidyl-tRNA synthetase
GRB95_RS10000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GRB95_RS10055	COG4974	Belongs to the 'phage' integrase family
GRB95_RS10065	COG0745	RESPONSE REGULATOR receiver
GRB95_RS10070	COG5002	protein histidine kinase activity
GRB95_RS10075	COG1288	antiporter activity
GRB95_RS10085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GRB95_RS10090	COG3852	Histidine kinase
GRB95_RS10095	COG0784	Response regulator, receiver
GRB95_RS10100	COG1125	glycine betaine transport
GRB95_RS10100	COG0517	IMP dehydrogenase activity
GRB95_RS10105	COG1174	glycine betaine transport
GRB95_RS10110	COG0392	lysyltransferase activity
GRB95_RS10110	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GRB95_RS10120	COG3759	membrane
GRB95_RS10150	COG0305	Participates in initiation and elongation during chromosome replication
GRB95_RS10165	COG0445	tRNA wobble uridine modification
GRB95_RS10170	COG2095	MarC family integral membrane protein
GRB95_RS10175	COG0482	sulfurtransferase activity
GRB95_RS10180	COG1760	l-serine dehydratase
GRB95_RS10185	COG1760	l-serine dehydratase
GRB95_RS10190	COG0741	lytic transglycosylase activity
GRB95_RS10215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GRB95_RS10220	COG0612	Peptidase, M16
GRB95_RS10225	COG0612	Peptidase, M16
GRB95_RS10230	COG2501	S4 domain
GRB95_RS10250	COG0517	IMP dehydrogenase activity
GRB95_RS10250	COG0516	GMP reductase activity
GRB95_RS10260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GRB95_RS10275	COG0454	-acetyltransferase
GRB95_RS10280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GRB95_RS10305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GRB95_RS10310	COG0488	(ABC) transporter
GRB95_RS10315	COG4485	Bacterial membrane protein, YfhO
GRB95_RS10335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GRB95_RS10340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GRB95_RS10345	COG1475	DNA binding