locus-tag class description CDH85_RS00020 COG2017 converts alpha-aldose to the beta-anomer CDH85_RS00025 COG1087 Belongs to the NAD(P)-dependent epimerase dehydratase family CDH85_RS00045 COG0395 ABC-type sugar transport system, permease component CDH85_RS00050 COG1175 transmembrane transport CDH85_RS00060 COG2207 Transcriptional regulator CDH85_RS00065 COG3414 Phosphotransferase system galactitol-specific IIB component CDH85_RS00070 COG3775 system Galactitol-specific IIC component CDH85_RS00080 COG0235 Class ii aldolase CDH85_RS00085 COG3775 system Galactitol-specific IIC component CDH85_RS00090 COG3414 Phosphotransferase system galactitol-specific IIB component CDH85_RS00095 COG1762 phosphoenolpyruvate-dependent sugar phosphotransferase system CDH85_RS00105 COG2226 methyltransferase CDH85_RS00150 COG0656 L-ascorbic acid biosynthetic process CDH85_RS00160 COG0789 Transcriptional regulator CDH85_RS00170 COG0599 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity CDH85_RS00215 COG1216 Glycosyl transferase, family 2 CDH85_RS00215 COG1442 glycosyl transferase family 8 CDH85_RS00225 COG2153 protein acetylation CDH85_RS00235 COG2265 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family CDH85_RS00295 COG0706 membrane insertase activity CDH85_RS00310 COG1210 Utp--glucose-1-phosphate uridylyltransferase CDH85_RS00315 COG1744 ABC transporter substrate-binding protein PnrA-like CDH85_RS00320 COG0457 Tetratricopeptide repeat CDH85_RS00320 COG0705 Rhomboid family CDH85_RS00325 COG0212 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family CDH85_RS00330 COG0166 Belongs to the GPI family CDH85_RS00345 COG1234 tRNA 3'-trailer cleavage CDH85_RS00350 COG1268 BioY protein CDH85_RS00370 COG5002 protein histidine kinase activity CDH85_RS00390 COG1832 CoA-binding protein CDH85_RS00395 COG0749 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity CDH85_RS00395 COG0258 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity CDH85_RS00405 COG2860 membrane CDH85_RS00430 COG0858 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA CDH85_RS00435 COG0532 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex CDH85_RS00445 COG2740 Nucleic-acid-binding protein implicated in transcription termination CDH85_RS00450 COG0195 Participates in both transcription termination and antitermination CDH85_RS00465 COG0220 tRNA (guanine-N7-)-methyltransferase activity CDH85_RS00475 COG4473 ABC transporter CDH85_RS00480 COG1131 (ABC) transporter CDH85_RS00495 COG0537 adenosine 5'-monophosphoramidase activity CDH85_RS00505 COG1316 TRANSCRIPTIONal CDH85_RS00515 COG0802 atpase or kinase CDH85_RS00520 COG2252 PERMEase CDH85_RS00535 COG0561 phosphatase activity CDH85_RS00550 COG3715 PTS system CDH85_RS00555 COG3716 PTS system mannose fructose sorbose family IID component CDH85_RS00570 COG0172 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) CDH85_RS00590 COG0439 Biotin carboxylase CDH85_RS00605 COG0304 beta-ketoacyl-acyl-carrier-protein synthase II activity CDH85_RS00610 COG1028 Short-chain dehydrogenase reductase Sdr CDH85_RS00615 COG0331 [acyl-carrier-protein] S-malonyltransferase activity CDH85_RS00620 COG2070 2-Nitropropane dioxygenase CDH85_RS00630 COG0332 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids CDH85_RS00640 COG1024 Enoyl-CoA hydratase CDH85_RS00650 COG0637 HAD-superfamily hydrolase subfamily IA, variant 3 CDH85_RS00655 COG0527 aspartate kinase activity CDH85_RS00690 COG1040 competence protein CDH85_RS00695 COG4098 Superfamily II DNA RNA helicase required for DNA uptake (late competence protein) CDH85_RS00700 COG1739 Uncharacterized protein family UPF0029 CDH85_RS00720 COG1882 Formate acetyltransferase CDH85_RS00725 COG1455 protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity CDH85_RS00735 COG1447 Phosphotransferase system cellobiose-specific component IIA CDH85_RS00745 COG1349 DNA-binding transcription factor activity CDH85_RS00750 COG1180 Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine CDH85_RS00755 COG1098 S1 RNA binding domain CDH85_RS00765 COG2197 response regulator CDH85_RS00770 COG4585 Histidine kinase CDH85_RS00780 COG2815 serine threonine protein kinase CDH85_RS00780 COG0515 serine threonine protein kinase CDH85_RS00790 COG0144 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA CDH85_RS00790 COG0781 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons CDH85_RS00795 COG0223 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus CDH85_RS00800 COG1198 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA CDH85_RS00810 COG0194 GDP metabolic process CDH85_RS00820 COG2197 response regulator CDH85_RS00825 COG4585 Histidine kinase CDH85_RS00835 COG1131 (ABC) transporter CDH85_RS00845 COG1418 mRNA catabolic process CDH85_RS00845 COG4372 Transposase CDH85_RS00850 COG1854 S-ribosylhomocysteine lyase activity CDH85_RS00860 COG0116 Belongs to the methyltransferase superfamily CDH85_RS00890 COG0744 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors CDH85_RS00895 COG3579 cysteine-type endopeptidase activity CDH85_RS00905 COG1488 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP CDH85_RS00910 COG0492 ferredoxin-NADP+ reductase activity CDH85_RS00920 COG1126 abc transporter atp-binding protein CDH85_RS00935 COG0513 Belongs to the DEAD box helicase family CDH85_RS00945 COG0768 penicillin binding CDH85_RS00965 COG0263 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate CDH85_RS00970 COG2190 (PTS) system CDH85_RS00970 COG1264 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity CDH85_RS00970 COG1263 PTS System CDH85_RS00980 COG1131 (ABC) transporter CDH85_RS01000 COG0446 pyridine nucleotide-disulphide oxidoreductase CDH85_RS01005 COG0580 Belongs to the MIP aquaporin (TC 1.A.8) family CDH85_RS01045 COG1755 Isoprenylcysteine carboxyl methyltransferase CDH85_RS01060 COG1695 Transcriptional regulator CDH85_RS01105 COG0519 Catalyzes the synthesis of GMP from XMP CDH85_RS01245 COG1732 Glycine betaine CDH85_RS01255 COG2814 Major facilitator Superfamily CDH85_RS01260 COG1396 sequence-specific DNA binding CDH85_RS01370 COG4974 Belongs to the 'phage' integrase family CDH85_RS01385 COG0102 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly CDH85_RS01415 COG1939 Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CDH85_RS01430 COG1045 serine acetyltransferase CDH85_RS01450 COG1018 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress CDH85_RS01455 COG1154 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) CDH85_RS01460 COG3959 Transketolase, thiamine diphosphate binding domain CDH85_RS01475 COG1762 phosphoenolpyruvate-dependent sugar phosphotransferase system CDH85_RS01480 COG0366 Alpha amylase catalytic CDH85_RS01485 COG1263 PTS System CDH85_RS01485 COG1264 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity CDH85_RS01495 COG1122 ATPase activity CDH85_RS01500 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components CDH85_RS01505 COG0601 transmembrane transport CDH85_RS01520 COG1346 cytolysis CDH85_RS01540 COG0637 HAD-superfamily hydrolase subfamily IA, variant 3 CDH85_RS01555 COG0073 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation CDH85_RS01560 COG0526 COG0526, thiol-disulfide isomerase and thioredoxins CDH85_RS01575 COG1363 Peptidase, m42 CDH85_RS01580 COG0345 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline CDH85_RS01640 COG1459 type II secretion system CDH85_RS01645 COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB CDH85_RS01670 COG4499 WXG100 protein secretion system (Wss), protein YukC CDH85_RS01670 COG0744 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors CDH85_RS01685 COG1108 ABC-type Mn2 Zn2 transport systems permease components CDH85_RS01690 COG1121 (ABC) transporter CDH85_RS01730 COG4608 Belongs to the ABC transporter superfamily CDH85_RS01735 COG0444 Belongs to the ABC transporter superfamily CDH85_RS01740 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components CDH85_RS01745 COG0601 transmembrane transport CDH85_RS01750 COG4166 transmembrane transport CDH85_RS01755 COG1686 Belongs to the peptidase S11 family CDH85_RS01760 COG1686 Belongs to the peptidase S11 family CDH85_RS01765 COG0719 Fe-S assembly protein CDH85_RS01775 COG0520 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine CDH85_RS01780 COG0719 Fe-S assembly protein CDH85_RS01790 COG0472 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan CDH85_RS01810 COG0765 amino acid transport CDH85_RS01815 COG1126 abc transporter atp-binding protein CDH85_RS01825 COG0745 RESPONSE REGULATOR receiver CDH85_RS01835 COG1755 Isoprenylcysteine carboxyl methyltransferase CDH85_RS01865 COG1461 Dihydroxyacetone kinase CDH85_RS01885 COG0191 fructose-bisphosphate aldolase activity CDH85_RS01900 COG5002 protein histidine kinase activity CDH85_RS01905 COG0745 RESPONSE REGULATOR receiver CDH85_RS01910 COG1136 (ABC) transporter CDH85_RS01915 COG0577 efflux transmembrane transporter activity CDH85_RS01925 COG1609 Transcriptional regulator CDH85_RS01930 COG0524 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway CDH85_RS01945 COG1172 Belongs to the binding-protein-dependent transport system permease family CDH85_RS01950 COG1879 ABC-type sugar transport system periplasmic component CDH85_RS01965 COG1249 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family CDH85_RS01980 COG0756 dUTP diphosphatase activity CDH85_RS02010 COG0668 transmembrane transport CDH85_RS02020 COG4720 Psort location CytoplasmicMembrane, score CDH85_RS02025 COG0351 phosphomethylpyrimidine kinase CDH85_RS02035 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs CDH85_RS02045 COG0443 Heat shock 70 kDa protein CDH85_RS02060 COG1705 Flagellar rod assembly protein muramidase FlgJ CDH85_RS02205 COG0202 RNA polymerase activity CDH85_RS02215 COG0099 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CDH85_RS02235 COG0201 protein transport CDH85_RS02345 COG0534 Mate efflux family protein CDH85_RS02355 COG1064 alcohol dehydrogenase CDH85_RS02360 COG1454 alcohol dehydrogenase CDH85_RS02360 COG1012 belongs to the aldehyde dehydrogenase family CDH85_RS02365 COG2755 lipolytic protein G-D-S-L family CDH85_RS02365 COG1835 transferase activity, transferring acyl groups other than amino-acyl groups CDH85_RS02375 COG0394 Belongs to the low molecular weight phosphotyrosine protein phosphatase family CDH85_RS02390 COG0015 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily CDH85_RS02405 COG0041 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) CDH85_RS02420 COG3458 cephalosporin-C deacetylase activity CDH85_RS02430 COG0329 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) CDH85_RS02445 COG0395 ABC-type sugar transport system, permease component CDH85_RS02450 COG1175 transmembrane transport CDH85_RS02485 COG0299 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate CDH85_RS02500 COG0046 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL CDH85_RS02510 COG0236 Carrier of the growing fatty acid chain in fatty acid biosynthesis CDH85_RS02530 COG0436 Aminotransferase CDH85_RS02715 COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins CDH85_RS02745 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog)) CDH85_RS02755 COG1197 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site CDH85_RS02765 COG0012 GTP binding CDH85_RS02780 COG1597 lipid kinase activity CDH85_RS02785 COG0592 DNA-directed DNA polymerase activity CDH85_RS02795 COG1475 DNA binding CDH85_RS02800 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain CDH85_RS02805 COG1576 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA CDH85_RS02825 COG4485 Bacterial membrane protein, YfhO CDH85_RS02830 COG0488 (ABC) transporter CDH85_RS02835 COG1284 Uncharacterised 5xTM membrane BCR, YitT family COG1284 CDH85_RS02850 COG0549 Belongs to the carbamate kinase family CDH85_RS02865 COG0454 -acetyltransferase CDH85_RS02880 COG0664 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein CDH85_RS02890 COG0517 IMP dehydrogenase activity CDH85_RS02890 COG0516 GMP reductase activity CDH85_RS02910 COG2501 S4 domain CDH85_RS02915 COG0612 Peptidase, M16 CDH85_RS02920 COG0612 Peptidase, M16 CDH85_RS02925 COG0558 Belongs to the CDP-alcohol phosphatidyltransferase class-I family CDH85_RS02950 COG0741 lytic transglycosylase activity CDH85_RS02955 COG1760 l-serine dehydratase CDH85_RS02960 COG1760 l-serine dehydratase CDH85_RS02965 COG0482 sulfurtransferase activity CDH85_RS02970 COG2095 MarC family integral membrane protein CDH85_RS02990 COG0305 Participates in initiation and elongation during chromosome replication CDH85_RS03005 COG0582 viral genome integration into host DNA CDH85_RS03015 COG2314 TM2 domain CDH85_RS03020 COG1396 sequence-specific DNA binding CDH85_RS03125 COG3759 membrane CDH85_RS03135 COG0392 lysyltransferase activity CDH85_RS03135 COG2898 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms CDH85_RS03140 COG1174 glycine betaine transport CDH85_RS03145 COG1125 glycine betaine transport CDH85_RS03145 COG0517 IMP dehydrogenase activity CDH85_RS03150 COG0784 Response regulator, receiver CDH85_RS03155 COG3852 Histidine kinase CDH85_RS03160 COG0078 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline CDH85_RS03170 COG1288 antiporter activity CDH85_RS03175 COG5002 protein histidine kinase activity CDH85_RS03180 COG0745 RESPONSE REGULATOR receiver CDH85_RS03245 COG0267 Belongs to the bacterial ribosomal protein bL33 family CDH85_RS03265 COG1284 Uncharacterised 5xTM membrane BCR, YitT family COG1284 CDH85_RS03270 COG1284 Uncharacterised 5xTM membrane BCR, YitT family COG1284 CDH85_RS03320 COG2818 Glycosylase CDH85_RS03330 COG0468 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage CDH85_RS03335 COG1393 Belongs to the ArsC family CDH85_RS03345 COG0816 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA CDH85_RS03365 COG1328 CTP reductase activity CDH85_RS03385 COG0602 queuosine metabolic process CDH85_RS03395 COG2514 catechol 2,3-dioxygenase activity CDH85_RS03400 COG0561 phosphatase activity CDH85_RS03410 COG4120 Belongs to the binding-protein-dependent transport system permease family CDH85_RS03415 COG1116 anion transmembrane transporter activity CDH85_RS03415 COG0715 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components CDH85_RS03420 COG0234 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter CDH85_RS03440 COG2820 Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis CDH85_RS03445 COG1972 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family CDH85_RS03465 COG0564 pseudouridine synthase activity CDH85_RS03470 COG0744 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors CDH85_RS03495 COG4667 esterase of the alpha-beta hydrolase superfamily CDH85_RS03500 COG2814 Major facilitator Superfamily CDH85_RS03515 COG2770 Histidine kinase CDH85_RS03515 COG2205 protein histidine kinase activity CDH85_RS03520 COG0745 RESPONSE REGULATOR receiver CDH85_RS03535 COG1296 Branched-chain amino acid permease (Azaleucine resistance) CDH85_RS03550 COG0685 methylenetetrahydrofolate reductase (NAD(P)H) activity CDH85_RS03550 COG0646 methionine synthase CDH85_RS03560 COG0371 Dehydrogenase CDH85_RS03580 COG2897 thiosulfate sulfurtransferase activity CDH85_RS03590 COG1611 Belongs to the LOG family CDH85_RS03595 COG1694 Mazg nucleotide pyrophosphohydrolase CDH85_RS03605 COG1396 sequence-specific DNA binding CDH85_RS03615 COG1131 (ABC) transporter CDH85_RS03665 COG1131 (ABC) transporter CDH85_RS03750 COG0693 protein deglycase activity CDH85_RS03755 COG2378 regulation of single-species biofilm formation CDH85_RS03780 COG2946 Replication initiation factor CDH85_RS03790 COG0582 viral genome integration into host DNA CDH85_RS03820 COG2256 atpase related to the helicase subunit of the holliday junction resolvase CDH85_RS03825 COG0456 acetyltransferase CDH85_RS03840 COG0494 nUDIX hydrolase CDH85_RS03850 COG0789 Transcriptional regulator CDH85_RS03865 COG1385 rRNA (uridine-N3-)-methyltransferase activity CDH85_RS03880 COG0573 inorganic phosphate transmembrane transporter activity CDH85_RS03885 COG0581 inorganic phosphate transmembrane transporter activity CDH85_RS03890 COG1117 ATPase-coupled phosphate ion transmembrane transporter activity CDH85_RS03900 COG0745 RESPONSE REGULATOR receiver CDH85_RS03905 COG5002 protein histidine kinase activity CDH85_RS03910 COG2190 (PTS) system CDH85_RS03910 COG1264 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity CDH85_RS03910 COG1263 PTS System CDH85_RS03930 COG3290 protein histidine kinase activity CDH85_RS03935 COG2274 protein secretion by the type I secretion system CDH85_RS03945 COG1131 (ABC) transporter CDH85_RS03980 COG3715 PTS system CDH85_RS03985 COG3716 PTS system mannose fructose sorbose family IID component CDH85_RS03990 COG2972 Histidine kinase CDH85_RS03995 COG4753 response regulator CDH85_RS03995 COG2207 Transcriptional regulator CDH85_RS04010 COG1363 Peptidase, m42 CDH85_RS04020 COG0737 Belongs to the 5'-nucleotidase family CDH85_RS04105 COG3842 ATPase activity CDH85_RS04115 COG1087 Belongs to the NAD(P)-dependent epimerase dehydratase family CDH85_RS04120 COG4565 transcriptional regulatory protein CDH85_RS04125 COG3290 protein histidine kinase activity CDH85_RS04130 COG3493 citrate carrier protein CDH85_RS04150 COG1862 Preprotein translocase CDH85_RS04155 COG0020 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids CDH85_RS04160 COG4589 Belongs to the CDS family CDH85_RS04175 COG1705 Flagellar rod assembly protein muramidase FlgJ CDH85_RS04175 COG1388 LysM domain CDH85_RS04180 COG2176 DNA-directed DNA polymerase activity CDH85_RS04205 COG1609 Transcriptional regulator CDH85_RS04235 COG3590 peptidase CDH85_RS04240 COG1619 proteins homologs of microcin C7 resistance protein MccF CDH85_RS04250 COG0025 NhaP-type Na H and K H CDH85_RS04265 COG0450 alkyl hydroperoxide reductase CDH85_RS04275 COG0264 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome CDH85_RS04285 COG4463 regulation of RNA biosynthetic process CDH85_RS04290 COG0542 response to heat CDH85_RS04300 COG1428 Deoxynucleoside kinase CDH85_RS04305 COG0042 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines CDH85_RS04390 COG1609 Transcriptional regulator CDH85_RS04400 COG1052 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family CDH85_RS04405 COG3775 system Galactitol-specific IIC component CDH85_RS04415 COG1070 Carbohydrate kinase CDH85_RS04435 COG3957 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase CDH85_RS04445 COG4175 Glycine betaine CDH85_RS04445 COG3448 diguanylate cyclase activity CDH85_RS04455 COG3314 Sporulation integral membrane protein YlbJ CDH85_RS04465 COG0745 RESPONSE REGULATOR receiver CDH85_RS04485 COG1696 Membrane protein involved in D-alanine export CDH85_RS04490 COG0236 Carrier of the growing fatty acid chain in fatty acid biosynthesis CDH85_RS04495 COG3966 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) CDH85_RS04520 COG0084 hydrolase, TatD family' CDH85_RS04545 COG1162 GTPase activity CDH85_RS04570 COG0503 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis CDH85_RS04600 COG2503 HAD superfamily, subfamily IIIB (Acid phosphatase) CDH85_RS04615 COG0789 Transcriptional regulator CDH85_RS04620 COG0174 glutamine synthetase CDH85_RS04625 COG3942 CHAP domain CDH85_RS04640 COG1214 PFAM Peptidase M22, glycoprotease CDH85_RS04645 COG0456 acetyltransferase CDH85_RS04675 COG2081 HI0933 family CDH85_RS04690 COG0789 Transcriptional regulator CDH85_RS04695 COG2230 cyclopropane-fatty-acyl-phospholipid synthase CDH85_RS04700 COG0718 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection CDH85_RS04715 COG2320 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A CDH85_RS04720 COG0656 L-ascorbic acid biosynthetic process CDH85_RS04735 COG4221 oxidoreductase activity CDH85_RS04755 COG3711 transcriptional antiterminator CDH85_RS04755 COG1762 phosphoenolpyruvate-dependent sugar phosphotransferase system CDH85_RS04760 COG1445 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity CDH85_RS04765 COG1762 phosphoenolpyruvate-dependent sugar phosphotransferase system CDH85_RS04770 COG1445 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity CDH85_RS04770 COG3925 protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity CDH85_RS04770 COG1299 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity CDH85_RS04775 COG0036 Belongs to the ribulose-phosphate 3-epimerase family CDH85_RS04815 COG1252 NADH dehydrogenase CDH85_RS04820 COG1271 oxidase subunit CDH85_RS04825 COG1294 oxidase, subunit CDH85_RS04830 COG4988 ABC transporter CDH85_RS04835 COG4987 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC CDH85_RS04840 COG0142 geranyltranstransferase activity CDH85_RS04855 COG0664 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein CDH85_RS04860 COG2814 Major facilitator Superfamily CDH85_RS04870 COG0580 Belongs to the MIP aquaporin (TC 1.A.8) family CDH85_RS04885 COG1680 COG1680 Beta-lactamase class C and other penicillin binding CDH85_RS04890 COG3576 pyridoxamine 5-phosphate CDH85_RS04895 COG1882 Formate acetyltransferase CDH85_RS04910 COG0507 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD CDH85_RS04915 COG0681 Belongs to the peptidase S26 family CDH85_RS04945 COG3118 belongs to the thioredoxin family CDH85_RS04955 COG1194 a g-specific adenine glycosylase CDH85_RS04960 COG0360 Binds together with S18 to 16S ribosomal RNA CDH85_RS04965 COG0629 single-stranded DNA binding CDH85_RS04995 COG2814 Major facilitator Superfamily CDH85_RS05010 COG0006 proline dipeptidase activity CDH85_RS05015 COG2131 deaminase CDH85_RS05065 COG0231 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase CDH85_RS05075 COG0781 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons CDH85_RS05080 COG1609 Transcriptional regulator CDH85_RS05085 COG1621 beta-fructofuranosidase activity CDH85_RS05090 COG1263 PTS System CDH85_RS05090 COG1264 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity CDH85_RS05090 COG2190 (PTS) system CDH85_RS05095 COG1940 carbohydrate kinase activity CDH85_RS05100 COG1482 cell wall glycoprotein biosynthetic process CDH85_RS05110 COG0722 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) CDH85_RS05115 COG0736 holo-[acyl-carrier-protein] synthase activity CDH85_RS05125 COG3942 CHAP domain CDH85_RS05125 COG1705 Flagellar rod assembly protein muramidase FlgJ CDH85_RS05130 COG1200 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) CDH85_RS05135 COG4989 oxidoreductase activity CDH85_RS05145 COG0252 asparaginase activity CDH85_RS05150 COG0561 phosphatase activity CDH85_RS05155 COG0589 response to stress CDH85_RS05160 COG0436 Aminotransferase CDH85_RS05165 COG4465 DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor CDH85_RS05170 COG1335 isochorismatase CDH85_RS05180 COG0517 IMP dehydrogenase activity CDH85_RS05190 COG0574 Belongs to the PEP-utilizing enzyme family CDH85_RS05190 COG1080 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) CDH85_RS05215 COG2179 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668 CDH85_RS05220 COG1161 Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity CDH85_RS05225 COG1534 Rna-binding protein CDH85_RS05230 COG1057 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) CDH85_RS05235 COG1713 HD superfamily hydrolase involved in NAD metabolism CDH85_RS05245 COG0799 negative regulation of ribosome biogenesis CDH85_RS05250 COG2226 methyltransferase CDH85_RS05265 COG0789 Transcriptional regulator CDH85_RS05275 COG0580 Belongs to the MIP aquaporin (TC 1.A.8) family CDH85_RS05280 COG3412 dihydroxyacetone kinase, phosphotransfer subunit CDH85_RS05285 COG1461 Dihydroxyacetone kinase CDH85_RS05290 COG2376 Dihydroxyacetone kinase CDH85_RS05300 COG1309 transcriptional regulator CDH85_RS05305 COG2376 Dihydroxyacetone kinase CDH85_RS05315 COG0217 transcriptional regulatory protein CDH85_RS05325 COG2071 gamma-glutamyl-gamma-aminobutyrate hydrolase activity CDH85_RS05330 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain CDH85_RS05355 COG1063 alcohol dehydrogenase CDH85_RS05360 COG1114 Component of the transport system for branched-chain amino acids CDH85_RS05385 COG0569 domain protein CDH85_RS05390 COG0168 Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA CDH85_RS05400 COG1704 LemA family CDH85_RS05415 COG0745 RESPONSE REGULATOR receiver CDH85_RS05420 COG5002 protein histidine kinase activity CDH85_RS05435 COG1484 DNA-dependent DNA replication CDH85_RS05470 COG1559 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation CDH85_RS05485 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain CDH85_RS05490 COG0765 amino acid transport CDH85_RS05500 COG1254 Belongs to the acylphosphatase family CDH85_RS05505 COG0566 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family CDH85_RS05520 COG1827 regulation of RNA biosynthetic process CDH85_RS05570 COG1187 pseudouridine synthase activity CDH85_RS05580 COG0168 Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA CDH85_RS05585 COG0569 domain protein CDH85_RS05590 COG0531 amino acid CDH85_RS05600 COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities CDH85_RS05605 COG0035 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate CDH85_RS05625 COG0559 Belongs to the binding-protein-dependent transport system permease family CDH85_RS05645 COG0517 IMP dehydrogenase activity CDH85_RS05660 COG0470 DNA polymerase III CDH85_RS05700 COG1052 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family CDH85_RS05705 COG0350 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated CDH85_RS05710 COG1393 Belongs to the ArsC family CDH85_RS05715 COG0708 Exodeoxyribonuclease III CDH85_RS05725 COG1455 protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity CDH85_RS05755 COG0143 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation CDH85_RS05755 COG0073 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation CDH85_RS05760 COG1114 Component of the transport system for branched-chain amino acids CDH85_RS05805 COG1028 Short-chain dehydrogenase reductase Sdr CDH85_RS05820 COG0673 inositol 2-dehydrogenase activity CDH85_RS05855 COG0775 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively CDH85_RS05880 COG0652 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides CDH85_RS05885 COG1674 ftsk spoiiie CDH85_RS05890 COG0147 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia CDH85_RS05910 COG0583 DNA-binding transcription factor activity CDH85_RS05915 COG1473 amidohydrolase CDH85_RS05935 COG0081 regulation of translation CDH85_RS05940 COG0747 negative chemotaxis CDH85_RS05945 COG0601 transmembrane transport CDH85_RS05950 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components CDH85_RS05955 COG0444 Belongs to the ABC transporter superfamily CDH85_RS05970 COG0233 cytoplasmic translational termination CDH85_RS05995 COG1702 phosphate starvation-inducible protein PhoH CDH85_RS06025 COG0319 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA CDH85_RS06030 COG0818 Recycling of diacylglycerol produced during the turnover of membrane phospholipid CDH85_RS06090 COG0266 class I DNA-(apurinic or apyrimidinic site) endonuclease activity CDH85_RS06100 COG1131 (ABC) transporter CDH85_RS06110 COG2814 Major facilitator Superfamily CDH85_RS06125 COG0557 exoribonuclease II activity CDH85_RS06130 COG0691 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene CDH85_RS06135 COG1113 amino acid transport CDH85_RS06140 COG0463 Glycosyl transferase, family 2 CDH85_RS06145 COG0346 lactoylglutathione lyase activity CDH85_RS06150 COG0778 Nitroreductase CDH85_RS06155 COG0656 L-ascorbic acid biosynthetic process CDH85_RS06160 COG1187 pseudouridine synthase activity CDH85_RS06165 COG0154 amidase activity CDH85_RS06175 COG2309 aminopeptidase activity CDH85_RS06200 COG1126 abc transporter atp-binding protein CDH85_RS06205 COG0765 amino acid transport CDH85_RS06235 COG1442 glycosyl transferase family 8 CDH85_RS06240 COG1442 glycosyl transferase family 8 CDH85_RS06240 COG1216 Glycosyl transferase, family 2 CDH85_RS06245 COG1442 glycosyl transferase family 8 CDH85_RS06250 COG1442 glycosyl transferase family 8 CDH85_RS06250 COG1216 Glycosyl transferase, family 2 CDH85_RS06255 COG1442 glycosyl transferase family 8 CDH85_RS06280 COG0653 protein targeting CDH85_RS06285 COG0438 transferase activity, transferring glycosyl groups CDH85_RS06305 COG3104 oligopeptide transport CDH85_RS06310 COG3833 ABC-type maltose transport systems, permease component CDH85_RS06315 COG1175 transmembrane transport CDH85_RS06325 COG1609 Transcriptional regulator CDH85_RS06330 COG1640 4-alpha-glucanotransferase CDH85_RS06335 COG0058 SHG alpha-glucan phosphorylase activity CDH85_RS06345 COG2271 Major facilitator Superfamily CDH85_RS06355 COG1054 Belongs to the UPF0176 family CDH85_RS06365 COG0004 ammonium transporteR CDH85_RS06370 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain CDH85_RS06385 COG1970 mechanosensitive ion channel activity CDH85_RS06390 COG0358 DNA primase activity CDH85_RS06395 COG0568 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released CDH85_RS06400 COG2151 metal-sulfur cluster biosynthetic enzyme CDH85_RS06405 COG1091 dTDP-4-dehydrorhamnose reductase activity CDH85_RS06415 COG1215 transferase activity, transferring glycosyl groups CDH85_RS06420 COG0463 Glycosyl transferase, family 2 CDH85_RS06435 COG3475 LICD family CDH85_RS06475 COG0297 glycogen (starch) synthase activity CDH85_RS06515 COG3601 Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins CDH85_RS06520 COG0671 phosphoesterase, PA-phosphatase related CDH85_RS06525 COG1242 4 iron, 4 sulfur cluster binding CDH85_RS06530 COG2519 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA CDH85_RS06535 COG1253 flavin adenine dinucleotide binding CDH85_RS06540 COG1180 Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine CDH85_RS06555 COG0609 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily CDH85_RS06560 COG0609 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily CDH85_RS06565 COG0614 abc-type fe3 -hydroxamate transport system, periplasmic component CDH85_RS06570 COG1120 ATPase activity CDH85_RS06580 COG2244 polysaccharide biosynthetic process CDH85_RS06610 COG0290 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins CDH85_RS06620 COG0292 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit CDH85_RS06625 COG1368 sulfuric ester hydrolase activity CDH85_RS06630 COG1092 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA CDH85_RS06655 COG1249 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family CDH85_RS06665 COG1104 cysteine desulfurase activity CDH85_RS06690 COG0211 Belongs to the bacterial ribosomal protein bL27 family CDH85_RS06695 COG0583 DNA-binding transcription factor activity CDH85_RS06705 COG0564 pseudouridine synthase activity CDH85_RS06715 COG0505 Belongs to the CarA family CDH85_RS06725 COG0845 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family CDH85_RS06730 COG1136 (ABC) transporter CDH85_RS06735 COG0577 efflux transmembrane transporter activity CDH85_RS06740 COG0228 four-way junction DNA binding CDH85_RS06745 COG1837 Belongs to the UPF0109 family CDH85_RS06800 COG1349 DNA-binding transcription factor activity CDH85_RS06805 COG1105 Belongs to the carbohydrate kinase PfkB family CDH85_RS06810 COG1762 phosphoenolpyruvate-dependent sugar phosphotransferase system CDH85_RS06810 COG1299 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity CDH85_RS06810 COG1445 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity CDH85_RS06840 COG0488 (ABC) transporter CDH85_RS06855 COG1132 (ABC) transporter CDH85_RS06865 COG0334 Belongs to the Glu Leu Phe Val dehydrogenases family CDH85_RS06870 COG0242 peptide deformylase activity CDH85_RS06875 COG0737 Belongs to the 5'-nucleotidase family CDH85_RS06890 COG1132 (ABC) transporter CDH85_RS06895 COG2357 RelA SpoT domain protein CDH85_RS06900 COG0745 RESPONSE REGULATOR receiver CDH85_RS06945 COG1272 protein, Hemolysin III CDH85_RS06960 COG3425 synthase CDH85_RS06970 COG0262 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis CDH85_RS07010 COG0833 amino acid CDH85_RS07015 COG2040 homocysteine CDH85_RS07060 COG1674 ftsk spoiiie CDH85_RS07090 COG4974 Belongs to the 'phage' integrase family CDH85_RS07100 COG2176 DNA-directed DNA polymerase activity CDH85_RS07120 COG0803 Belongs to the bacterial solute-binding protein 9 family CDH85_RS07160 COG0534 Mate efflux family protein CDH85_RS07185 COG0624 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls CDH85_RS07190 COG1573 uracil-dna glycosylase CDH85_RS07200 COG1523 belongs to the glycosyl hydrolase 13 family CDH85_RS07220 COG2262 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis CDH85_RS07235 COG0300 oxidoreductase activity CDH85_RS07240 COG4199 Single-strand DNA-specific exonuclease, C terminal domain CDH85_RS07240 COG0608 single-stranded DNA 5'-3' exodeoxyribonuclease activity CDH85_RS07265 COG2384 SAM-dependent methyltransferase CDH85_RS07275 COG0665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity CDH85_RS07280 COG1209 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis CDH85_RS07290 COG1088 dTDP-glucose 4,6-dehydratase activity CDH85_RS07295 COG5492 domain, Protein CDH85_RS07300 COG1051 belongs to the nudix hydrolase family CDH85_RS07310 COG0628 permease CDH85_RS07315 COG0457 Tetratricopeptide repeat CDH85_RS07320 COG0028 Belongs to the TPP enzyme family CDH85_RS07325 COG3527 Alpha-acetolactate decarboxylase CDH85_RS07330 COG1293 RNA-binding protein homologous to eukaryotic snRNP CDH85_RS07345 COG3842 ATPase activity CDH85_RS07380 COG0005 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate CDH85_RS07405 COG1316 TRANSCRIPTIONal CDH85_RS07430 COG0707 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) CDH85_RS07465 COG2089 acid synthase CDH85_RS07480 COG2755 lipolytic protein G-D-S-L family CDH85_RS07480 COG1083 cytidylyl-transferase CDH85_RS07490 COG0692 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine CDH85_RS07495 COG0344 acyl-phosphate glycerol-3-phosphate acyltransferase activity CDH85_RS07500 COG0187 DNA topoisomerase II activity CDH85_RS07510 COG0115 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family CDH85_RS07530 COG0539 negative regulation of cytoplasmic translation CDH85_RS07540 COG4974 Belongs to the 'phage' integrase family CDH85_RS07575 COG1346 cytolysis CDH85_RS07585 COG0053 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family CDH85_RS07590 COG1115 amino acid carrier protein CDH85_RS07615 COG2261 transglycosylase associated protein CDH85_RS07690 COG1012 belongs to the aldehyde dehydrogenase family CDH85_RS07700 COG1292 Belongs to the BCCT transporter (TC 2.A.15) family CDH85_RS07705 COG0726 polysaccharide deacetylase CDH85_RS07720 COG2962 Rard protein CDH85_RS07725 COG0285 dihydrofolate synthase activity CDH85_RS07745 COG0801 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CDH85_RS07750 COG0812 UDP-N-acetylmuramate dehydrogenase activity CDH85_RS07760 COG1176 ABC-type spermidine putrescine transport system, permease component I CDH85_RS07765 COG1177 transmembrane transport CDH85_RS07775 COG0038 chloride channel CDH85_RS07790 COG0561 phosphatase activity CDH85_RS07800 COG2723 6-phospho-beta-galactosidase activity CDH85_RS07805 COG0628 permease CDH85_RS07810 COG2003 Belongs to the UPF0758 family CDH85_RS07815 COG2344 Modulates transcription in response to changes in cellular NADH NAD( ) redox state CDH85_RS07825 COG1104 cysteine desulfurase activity CDH85_RS07840 COG2357 RelA SpoT domain protein CDH85_RS07845 COG0061 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP CDH85_RS07850 COG0564 pseudouridine synthase activity CDH85_RS07855 COG0280 phosphate acetyltransferase CDH85_RS07860 COG4221 oxidoreductase activity CDH85_RS07875 COG0477 Major facilitator Superfamily CDH85_RS07890 COG2233 PERMEase CDH85_RS07900 COG3976 FMN-binding domain protein CDH85_RS07900 COG1053 succinate dehydrogenase CDH85_RS07900 COG0431 NADPH-dependent FMN reductase CDH85_RS07920 COG1942 4-Oxalocrotonate Tautomerase CDH85_RS07935 COG2890 protein-(glutamine-N5) methyltransferase activity CDH85_RS07965 COG1132 (ABC) transporter CDH85_RS07975 COG1109 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate CDH85_RS07980 COG4684 Psort location CytoplasmicMembrane, score CDH85_RS07985 COG0452 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine CDH85_RS07995 COG0095 Lipoate-protein ligase CDH85_RS08035 COG1502 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol CDH85_RS08050 COG0136 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate CDH85_RS08060 COG0488 (ABC) transporter CDH85_RS08080 COG0044 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides CDH85_RS08090 COG0505 Belongs to the CarA family CDH85_RS08215 COG3275 phosphorelay sensor kinase activity CDH85_RS08220 COG3279 Response regulator of the LytR AlgR family CDH85_RS08225 COG1966 Carbon starvation protein CDH85_RS08230 COG1376 ErfK ybiS ycfS ynhG family protein CDH85_RS08235 COG1161 Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity CDH85_RS08250 COG4606 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily CDH85_RS08255 COG4605 iron ion homeostasis CDH85_RS08260 COG4604 ABC transporter, ATP-binding protein CDH85_RS08265 COG4594 ABC-type Fe3 -citrate transport system, periplasmic component CDH85_RS08270 COG0758 DNA mediated transformation CDH85_RS08275 COG0550 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone CDH85_RS08280 COG1136 (ABC) transporter CDH85_RS08310 COG0130 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs CDH85_RS08315 COG0196 riboflavin kinase activity CDH85_RS08330 COG0483 inositol monophosphate 1-phosphatase activity CDH85_RS08335 COG0144 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA CDH85_RS08335 COG3270 Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA CDH85_RS08345 COG0573 inorganic phosphate transmembrane transporter activity CDH85_RS08350 COG0581 inorganic phosphate transmembrane transporter activity CDH85_RS08355 COG1117 ATPase-coupled phosphate ion transmembrane transporter activity CDH85_RS08360 COG1117 ATPase-coupled phosphate ion transmembrane transporter activity CDH85_RS08365 COG0704 Plays a role in the regulation of phosphate uptake CDH85_RS08375 COG0745 RESPONSE REGULATOR receiver CDH85_RS08380 COG5002 protein histidine kinase activity CDH85_RS08385 COG2739 Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein CDH85_RS08390 COG0541 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CDH85_RS08405 COG4166 transmembrane transport CDH85_RS08410 COG4974 Belongs to the 'phage' integrase family CDH85_RS08415 COG5002 protein histidine kinase activity CDH85_RS08420 COG0745 RESPONSE REGULATOR receiver CDH85_RS08430 COG1136 (ABC) transporter CDH85_RS08445 COG1464 Belongs to the NlpA lipoprotein family CDH85_RS08460 COG2188 Transcriptional regulator CDH85_RS08485 COG0346 lactoylglutathione lyase activity CDH85_RS08490 COG3764 Sortase (surface protein transpeptidase) CDH85_RS08510 COG1079 Belongs to the binding-protein-dependent transport system permease family CDH85_RS08515 COG4603 Belongs to the binding-protein-dependent transport system permease family CDH85_RS08520 COG3845 ABC transporter CDH85_RS08525 COG1744 ABC transporter substrate-binding protein PnrA-like CDH85_RS08535 COG2813 Specifically methylates the guanine in position CDH85_RS08540 COG1072 (Pantothenic acid kinase)) CDH85_RS08555 COG1126 abc transporter atp-binding protein CDH85_RS08560 COG0765 amino acid transport CDH85_RS08565 COG2824 Alkylphosphonate utilization operon protein PhnA CDH85_RS08570 COG0449 glutamine-fructose-6-phosphate transaminase (isomerizing) activity CDH85_RS08585 COG0469 pyruvate kinase activity CDH85_RS08590 COG0205 6-phosphofructokinase activity CDH85_RS08600 COG1725 Transcriptional regulator CDH85_RS08605 COG1131 (ABC) transporter CDH85_RS08675 COG0741 lytic transglycosylase activity CDH85_RS08675 COG0791 NLP P60 protein CDH85_RS08705 COG2946 Replication initiation factor CDH85_RS08715 COG1674 ftsk spoiiie CDH85_RS08755 COG0474 ATPase, P-type transporting, HAD superfamily, subfamily IC CDH85_RS08765 COG0456 acetyltransferase CDH85_RS08770 COG1418 mRNA catabolic process CDH85_RS08780 COG0481 GTPase activity CDH85_RS08800 COG3512 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette CDH85_RS08805 COG1518 maintenance of DNA repeat elements CDH85_RS08810 COG3513 CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer CDH85_RS08820 COG0647 UMP catabolic process CDH85_RS08830 COG0635 Involved in the biosynthesis of porphyrin-containing compound CDH85_RS08855 COG1624 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria CDH85_RS08860 COG0770 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity CDH85_RS08865 COG3442 glutamine amidotransferase CDH85_RS08870 COG0095 Lipoate-protein ligase CDH85_RS08880 COG0508 dehydrogenase complex catalyzes the overall conversion of CDH85_RS08885 COG0022 dehydrogenase e1 component CDH85_RS08885 COG0508 dehydrogenase complex catalyzes the overall conversion of CDH85_RS08890 COG1071 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor CDH85_RS08895 COG0488 (ABC) transporter CDH85_RS08920 COG2321 neutral zinc metallopeptidase CDH85_RS09005 COG0448 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans CDH85_RS09020 COG1523 belongs to the glycosyl hydrolase 13 family CDH85_RS09025 COG1597 lipid kinase activity CDH85_RS09035 COG4708 membrane CDH85_RS09040 COG2246 polysaccharide biosynthetic process CDH85_RS09050 COG0024 Methionine aminopeptidase CDH85_RS09055 COG4109 DRTGG domain CDH85_RS09085 COG0819 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway CDH85_RS09095 COG1122 ATPase activity CDH85_RS09100 COG4721 ABC-type cobalt transport system, permease component CDH85_RS09130 COG0340 biotin-[acetyl-CoA-carboxylase] ligase activity CDH85_RS09130 COG1654 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon CDH85_RS09140 COG2812 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity CDH85_RS09145 COG1956 GAF domain-containing protein CDH85_RS09160 COG0726 polysaccharide deacetylase CDH85_RS09165 COG1012 belongs to the aldehyde dehydrogenase family CDH85_RS09180 COG0695 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins CDH85_RS09185 COG0209 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides CDH85_RS09190 COG0208 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides CDH85_RS09205 COG1476 TRANSCRIPTIONal CDH85_RS09215 COG1442 glycosyl transferase family 8 CDH85_RS09220 COG1811 Na channel or pump CDH85_RS09230 COG4894 glucomannan catabolic process CDH85_RS09240 COG4122 O-methyltransferase activity CDH85_RS09245 COG0241 D,D-heptose 1,7-bisphosphate phosphatase CDH85_RS09270 COG1187 pseudouridine synthase activity CDH85_RS09275 COG0435 Glutathione S-transferase CDH85_RS09280 COG0363 glucosamine-6-phosphate deaminase activity CDH85_RS09295 COG1846 Transcriptional regulator CDH85_RS09305 COG2610 gluconate transmembrane transporter activity CDH85_RS09310 COG1929 Belongs to the glycerate kinase type-1 family CDH85_RS09315 COG3835 regulator CDH85_RS09325 COG1263 PTS System CDH85_RS09325 COG1264 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity CDH85_RS09325 COG2190 (PTS) system CDH85_RS09330 COG3711 transcriptional antiterminator CDH85_RS09335 COG0605 Destroys radicals which are normally produced within the cells and which are toxic to biological systems CDH85_RS09345 COG2226 methyltransferase CDH85_RS09350 COG0657 acetylesterase activity CDH85_RS09355 COG1609 Transcriptional regulator CDH85_RS09360 COG0561 phosphatase activity CDH85_RS09365 COG2333 competence protein COMEC CDH85_RS09365 COG0658 competence protein CDH85_RS09370 COG1596 polysaccharide export CDH85_RS09370 COG1555 photosystem II stabilization CDH85_RS09375 COG0204 Acyl-transferase CDH85_RS09380 COG4123 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) CDH85_RS09390 COG0513 Belongs to the DEAD box helicase family CDH85_RS09395 COG1464 Belongs to the NlpA lipoprotein family CDH85_RS09400 COG2011 ABC-type metal ion transport system permease component CDH85_RS09405 COG1135 Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system CDH85_RS09430 COG2223 nitrite transmembrane transporter activity CDH85_RS09435 COG0770 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity CDH85_RS09450 COG0768 penicillin binding CDH85_RS09470 COG0772 Belongs to the SEDS family CDH85_RS09480 COG1164 Oligoendopeptidase f CDH85_RS09505 COG2606 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily CDH85_RS09530 COG0108 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate CDH85_RS09530 COG0807 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate CDH85_RS09545 COG1914 H( )-stimulated, divalent metal cation uptake system CDH85_RS09555 COG4443 Transcriptional Coactivator p15 (PC4) CDH85_RS09560 COG0826 peptidase U32 CDH85_RS09600 COG1983 PspC domain protein CDH85_RS09605 COG3091 SprT-like family CDH85_RS09610 COG2183 response to ionizing radiation CDH85_RS09625 COG0701 Predicted permease CDH85_RS09630 COG3689 TIGRFAM TIGR03943 family protein CDH85_RS09635 COG0552 protein localization to endoplasmic reticulum CDH85_RS09640 COG0561 phosphatase activity CDH85_RS09645 COG0561 phosphatase activity CDH85_RS09650 COG1196 nuclear chromosome segregation CDH85_RS09660 COG2832 Protein of unknown function (DUF454) CDH85_RS09665 COG1235 May be involved in the transport of PQQ or its precursor to the periplasm CDH85_RS09670 COG5002 protein histidine kinase activity CDH85_RS09675 COG0745 RESPONSE REGULATOR receiver CDH85_RS09680 COG1126 abc transporter atp-binding protein CDH85_RS09685 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain CDH85_RS09690 COG0765 amino acid transport CDH85_RS09695 COG0765 amino acid transport CDH85_RS09720 COG0438 transferase activity, transferring glycosyl groups CDH85_RS09735 COG1609 Transcriptional regulator CDH85_RS09755 COG1028 Short-chain dehydrogenase reductase Sdr CDH85_RS09770 COG0800 Aldolase CDH85_RS09780 COG2186 Transcriptional regulator CDH85_RS09785 COG3250 beta-galactosidase activity CDH85_RS09795 COG2211 Major facilitator Superfamily CDH85_RS09815 COG0583 DNA-binding transcription factor activity CDH85_RS09825 COG0390 transport system, permease component CDH85_RS09830 COG4619 ABC transporter CDH85_RS09835 COG0586 Pfam SNARE associated Golgi protein CDH85_RS09850 COG1136 (ABC) transporter CDH85_RS09900 COG3590 peptidase CDH85_RS09905 COG3590 peptidase CDH85_RS09930 COG0304 beta-ketoacyl-acyl-carrier-protein synthase II activity CDH85_RS09935 COG0404 The glycine cleavage system catalyzes the degradation of glycine CDH85_RS09955 COG0764 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity CDH85_RS09960 COG0236 Carrier of the growing fatty acid chain in fatty acid biosynthesis CDH85_RS09965 COG1028 Short-chain dehydrogenase reductase Sdr CDH85_RS09995 COG4555 ABC transporter CDH85_RS10000 COG1680 COG1680 Beta-lactamase class C and other penicillin binding CDH85_RS10105 COG3700 Belongs to the class B bacterial acid phosphatase family CDH85_RS10120 COG1316 TRANSCRIPTIONal CDH85_RS10140 COG0148 phosphopyruvate hydratase activity CDH85_RS10155 COG0560 Phosphoserine phosphatase CDH85_RS10175 COG0772 Belongs to the SEDS family CDH85_RS10195 COG5002 protein histidine kinase activity CDH85_RS10210 COG1136 (ABC) transporter CDH85_RS10260 COG0335 large ribosomal subunit rRNA binding CDH85_RS10265 COG0038 chloride channel CDH85_RS10270 COG1605 Chorismate mutase CDH85_RS10270 COG2876 3-deoxy-7-phosphoheptulonate synthase activity CDH85_RS10275 COG0716 FMN binding CDH85_RS10280 COG1816 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism CDH85_RS10285 COG0618 3'(2'),5'-bisphosphate nucleotidase activity CDH85_RS10290 COG0254 rRNA binding CDH85_RS10315 COG1660 Displays ATPase and GTPase activities CDH85_RS10340 COG0017 Asparaginyl-tRNA synthetase CDH85_RS10345 COG0436 Aminotransferase CDH85_RS10370 COG2177 Part of the ABC transporter FtsEX involved in CDH85_RS10375 COG2884 Cell division ATP-binding protein ftsE CDH85_RS10385 COG1600 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) CDH85_RS10410 COG1078 dGTPase activity CDH85_RS10455 COG2755 lipolytic protein G-D-S-L family CDH85_RS10460 COG1307 EDD domain protein, DegV family CDH85_RS10465 COG0497 DNA recombination CDH85_RS10470 COG1438 arginine binding CDH85_RS10475 COG1189 Ribosomal RNA methyltransferase RrmJ FtsJ CDH85_RS10485 COG1722 exodeoxyribonuclease VII activity CDH85_RS10490 COG1570 exodeoxyribonuclease VII activity CDH85_RS10495 COG0063 ADP-dependent NAD(P)H-hydrate dehydratase activity CDH85_RS10505 COG1109 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate CDH85_RS10510 COG1126 abc transporter atp-binding protein CDH85_RS10515 COG0765 amino acid transport CDH85_RS10520 COG4703 Protein of unknown function (DUF1797) CDH85_RS10530 COG0542 response to heat CDH85_RS10535 COG0494 nUDIX hydrolase CDH85_RS10550 COG3599 regulation of cell shape CDH85_RS10555 COG2302 S4 RNA-binding domain CDH85_RS10560 COG0762 integral membrane protein CDH85_RS10570 COG0325 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis CDH85_RS10595 COG0771 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) CDH85_RS10605 COG1217 gtp-binding protein TYPA CDH85_RS10610 COG0607 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS CDH85_RS10615 COG1940 carbohydrate kinase activity CDH85_RS10630 COG0177 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate CDH85_RS10650 COG0502 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism CDH85_RS10655 COG1268 BioY protein CDH85_RS10660 COG0512 Glutamine amidotransferase of anthranilate synthase CDH85_RS10665 COG1132 (ABC) transporter CDH85_RS10670 COG1132 (ABC) transporter CDH85_RS10685 COG4470 Protein conserved in bacteria CDH85_RS10690 COG0737 Belongs to the 5'-nucleotidase family CDH85_RS10695 COG3480 Lon protease (S16) C-terminal proteolytic domain CDH85_RS10710 COG0742 ribosomal rna small subunit methyltransferase CDH85_RS10725 COG2315 Protein conserved in bacteria CDH85_RS10735 COG0673 inositol 2-dehydrogenase activity CDH85_RS10740 COG1343 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette CDH85_RS10745 COG1518 maintenance of DNA repeat elements