locus-tag	class	description
A6J82_RS00010	COG1349	DNA-binding transcription factor activity
A6J82_RS00015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J82_RS00020	COG1098	S1 RNA binding domain
A6J82_RS00030	COG2197	response regulator
A6J82_RS00035	COG4585	Histidine kinase
A6J82_RS00045	COG2815	serine threonine protein kinase
A6J82_RS00045	COG0515	serine threonine protein kinase
A6J82_RS00055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J82_RS00055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J82_RS00060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J82_RS00065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J82_RS00075	COG0194	GDP metabolic process
A6J82_RS00085	COG2197	response regulator
A6J82_RS00100	COG1131	(ABC) transporter
A6J82_RS00110	COG1418	mRNA catabolic process
A6J82_RS00110	COG4372	Transposase
A6J82_RS00115	COG1854	S-ribosylhomocysteine lyase activity
A6J82_RS00125	COG0116	Belongs to the methyltransferase superfamily
A6J82_RS00155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J82_RS00160	COG3579	cysteine-type endopeptidase activity
A6J82_RS00175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J82_RS00180	COG0492	ferredoxin-NADP+ reductase activity
A6J82_RS00190	COG1126	abc transporter atp-binding protein
A6J82_RS00205	COG0513	Belongs to the DEAD box helicase family
A6J82_RS00215	COG0768	penicillin binding
A6J82_RS00225	COG0275	rRNA processing
A6J82_RS00230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6J82_RS00235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6J82_RS00240	COG2190	(PTS) system
A6J82_RS00240	COG1263	PTS System
A6J82_RS00240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J82_RS00250	COG1131	(ABC) transporter
A6J82_RS00270	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J82_RS00275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J82_RS00315	COG1755	Isoprenylcysteine carboxyl methyltransferase
A6J82_RS00330	COG1695	Transcriptional regulator
A6J82_RS00375	COG0519	Catalyzes the synthesis of GMP from XMP
A6J82_RS00475	COG1732	Glycine betaine
A6J82_RS00485	COG2814	Major facilitator Superfamily
A6J82_RS00490	COG1396	sequence-specific DNA binding
A6J82_RS00600	COG4974	Belongs to the 'phage' integrase family
A6J82_RS00615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J82_RS00620	COG1476	TRANSCRIPTIONal
A6J82_RS00650	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A6J82_RS00655	COG0215	cysteine-tRNA ligase activity
A6J82_RS00665	COG1045	serine acetyltransferase
A6J82_RS00685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J82_RS00690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6J82_RS00695	COG3959	Transketolase, thiamine diphosphate binding domain
A6J82_RS00710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J82_RS00715	COG0366	Alpha amylase catalytic
A6J82_RS00720	COG1263	PTS System
A6J82_RS00720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J82_RS00730	COG1122	ATPase activity
A6J82_RS00735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J82_RS00740	COG0601	transmembrane transport
A6J82_RS00755	COG1346	cytolysis
A6J82_RS00775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J82_RS00790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J82_RS00795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J82_RS00810	COG1363	Peptidase, m42
A6J82_RS00815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J82_RS00855	COG1459	type II secretion system
A6J82_RS00860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J82_RS00870	COG3344	reverse transcriptase
A6J82_RS00890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J82_RS00890	COG4499	WXG100 protein secretion system (Wss), protein YukC
A6J82_RS00895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J82_RS01005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J82_RS01010	COG1121	(ABC) transporter
A6J82_RS01050	COG4608	Belongs to the ABC transporter superfamily
A6J82_RS01055	COG0444	Belongs to the ABC transporter superfamily
A6J82_RS01060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J82_RS01065	COG0601	transmembrane transport
A6J82_RS01070	COG4166	transmembrane transport
A6J82_RS01075	COG1686	Belongs to the peptidase S11 family
A6J82_RS01080	COG1686	Belongs to the peptidase S11 family
A6J82_RS01085	COG0719	Fe-S assembly protein
A6J82_RS01095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J82_RS01100	COG0719	Fe-S assembly protein
A6J82_RS01120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J82_RS01140	COG0765	amino acid transport
A6J82_RS01145	COG1126	abc transporter atp-binding protein
A6J82_RS01165	COG1461	Dihydroxyacetone kinase
A6J82_RS01185	COG0191	fructose-bisphosphate aldolase activity
A6J82_RS01200	COG5002	protein histidine kinase activity
A6J82_RS01205	COG0745	RESPONSE REGULATOR receiver
A6J82_RS01210	COG1136	(ABC) transporter
A6J82_RS01215	COG0577	efflux transmembrane transporter activity
A6J82_RS01225	COG1609	Transcriptional regulator
A6J82_RS01230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J82_RS01245	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J82_RS01250	COG1879	ABC-type sugar transport system periplasmic component
A6J82_RS01255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J82_RS01260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J82_RS01275	COG0756	dUTP diphosphatase activity
A6J82_RS01305	COG0668	transmembrane transport
A6J82_RS01315	COG4720	Psort location CytoplasmicMembrane, score
A6J82_RS01320	COG0351	phosphomethylpyrimidine kinase
A6J82_RS01325	COG0101	tRNA pseudouridine synthase activity
A6J82_RS01330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J82_RS01340	COG0443	Heat shock 70 kDa protein
A6J82_RS01355	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J82_RS01375	COG3344	reverse transcriptase
A6J82_RS01500	COG0202	RNA polymerase activity
A6J82_RS01510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6J82_RS01525	COG0563	adenylate kinase activity
A6J82_RS01530	COG0201	protein transport
A6J82_RS01640	COG0534	Mate efflux family protein
A6J82_RS01650	COG1064	alcohol dehydrogenase
A6J82_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
A6J82_RS01655	COG1454	alcohol dehydrogenase
A6J82_RS01660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6J82_RS01660	COG2755	lipolytic protein G-D-S-L family
A6J82_RS01670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J82_RS01685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J82_RS01715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J82_RS01730	COG3458	cephalosporin-C deacetylase activity
A6J82_RS01740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J82_RS01755	COG0395	ABC-type sugar transport system, permease component
A6J82_RS01760	COG1175	transmembrane transport
A6J82_RS01785	COG0138	bifunctional purine biosynthesis protein purh
A6J82_RS01795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J82_RS01800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6J82_RS01815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J82_RS01820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6J82_RS01825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J82_RS01830	COG0416	fatty acid biosynthetic process
A6J82_RS01850	COG0436	Aminotransferase
A6J82_RS02035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J82_RS02065	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J82_RS02075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J82_RS02085	COG0012	GTP binding
A6J82_RS02100	COG1597	lipid kinase activity
A6J82_RS02110	COG0592	DNA-directed DNA polymerase activity
A6J82_RS02120	COG1475	DNA binding
A6J82_RS02125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J82_RS02130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6J82_RS02150	COG4485	Bacterial membrane protein, YfhO
A6J82_RS02155	COG0488	(ABC) transporter
A6J82_RS02160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J82_RS02175	COG0549	Belongs to the carbamate kinase family
A6J82_RS02190	COG0454	-acetyltransferase
A6J82_RS02205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J82_RS02215	COG0517	IMP dehydrogenase activity
A6J82_RS02215	COG0516	GMP reductase activity
A6J82_RS02230	COG3344	reverse transcriptase
A6J82_RS02245	COG2501	S4 domain
A6J82_RS02250	COG0612	Peptidase, M16
A6J82_RS02255	COG0612	Peptidase, M16
A6J82_RS02260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J82_RS02285	COG0741	lytic transglycosylase activity
A6J82_RS02295	COG1760	l-serine dehydratase
A6J82_RS02300	COG1760	l-serine dehydratase
A6J82_RS02305	COG0482	sulfurtransferase activity
A6J82_RS02310	COG2095	MarC family integral membrane protein
A6J82_RS02330	COG0305	Participates in initiation and elongation during chromosome replication
A6J82_RS02345	COG0582	viral genome integration into host DNA
A6J82_RS02475	COG3759	membrane
A6J82_RS02485	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6J82_RS02485	COG0392	lysyltransferase activity
A6J82_RS02495	COG1125	glycine betaine transport
A6J82_RS02495	COG0517	IMP dehydrogenase activity
A6J82_RS02500	COG0784	Response regulator, receiver
A6J82_RS02505	COG3852	Histidine kinase
A6J82_RS02510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6J82_RS02520	COG1288	antiporter activity
A6J82_RS02525	COG3344	reverse transcriptase
A6J82_RS02530	COG5002	protein histidine kinase activity
A6J82_RS02535	COG0745	RESPONSE REGULATOR receiver
A6J82_RS02545	COG4974	Belongs to the 'phage' integrase family
A6J82_RS02615	COG3177	Filamentation induced by cAMP protein fic
A6J82_RS02645	COG2946	Replication initiation factor
A6J82_RS02655	COG4974	Belongs to the 'phage' integrase family
A6J82_RS02665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J82_RS02685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J82_RS02690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J82_RS02700	COG0018	arginyl-trna synthetase
A6J82_RS02740	COG2818	Glycosylase
A6J82_RS02745	COG1546	Belongs to the CinA family
A6J82_RS02745	COG1058	Belongs to the CinA family
A6J82_RS02750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6J82_RS02755	COG1393	Belongs to the ArsC family
A6J82_RS02765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6J82_RS02785	COG1328	CTP reductase activity
A6J82_RS02785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6J82_RS02805	COG0602	queuosine metabolic process
A6J82_RS02810	COG3022	response to hydroperoxide
A6J82_RS02815	COG2514	catechol 2,3-dioxygenase activity
A6J82_RS02820	COG0561	phosphatase activity
A6J82_RS02830	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6J82_RS02835	COG1116	anion transmembrane transporter activity
A6J82_RS02835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J82_RS02840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6J82_RS02860	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6J82_RS02865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J82_RS02885	COG0564	pseudouridine synthase activity
A6J82_RS02890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J82_RS02915	COG4667	esterase of the alpha-beta hydrolase superfamily
A6J82_RS02920	COG2814	Major facilitator Superfamily
A6J82_RS02925	COG5433	transposase activity
A6J82_RS02945	COG2205	protein histidine kinase activity
A6J82_RS02945	COG2770	Histidine kinase
A6J82_RS02950	COG0745	RESPONSE REGULATOR receiver
A6J82_RS02965	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A6J82_RS02980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6J82_RS02980	COG0646	methionine synthase
A6J82_RS03000	COG0371	Dehydrogenase
A6J82_RS03020	COG2897	thiosulfate sulfurtransferase activity
A6J82_RS03035	COG1694	Mazg nucleotide pyrophosphohydrolase
A6J82_RS03050	COG1396	sequence-specific DNA binding
A6J82_RS03060	COG1131	(ABC) transporter
A6J82_RS03130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J82_RS03135	COG0456	acetyltransferase
A6J82_RS03170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J82_RS03185	COG0573	inorganic phosphate transmembrane transporter activity
A6J82_RS03190	COG0581	inorganic phosphate transmembrane transporter activity
A6J82_RS03195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J82_RS03205	COG0745	RESPONSE REGULATOR receiver
A6J82_RS03210	COG5002	protein histidine kinase activity
A6J82_RS03215	COG2190	(PTS) system
A6J82_RS03215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J82_RS03215	COG1263	PTS System
A6J82_RS03225	COG3279	Response regulator of the LytR AlgR family
A6J82_RS03235	COG1131	(ABC) transporter
A6J82_RS03265	COG3715	PTS system
A6J82_RS03270	COG3716	PTS system mannose fructose sorbose family IID component
A6J82_RS03275	COG2972	Histidine kinase
A6J82_RS03280	COG2207	Transcriptional regulator
A6J82_RS03280	COG4753	response regulator
A6J82_RS03295	COG1363	Peptidase, m42
A6J82_RS03305	COG0737	Belongs to the 5'-nucleotidase family
A6J82_RS03315	COG1490	D-aminoacyl-tRNA deacylase activity
A6J82_RS03385	COG3842	ATPase activity
A6J82_RS03395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J82_RS03400	COG4565	transcriptional regulatory protein
A6J82_RS03405	COG3290	protein histidine kinase activity
A6J82_RS03410	COG3493	citrate carrier protein
A6J82_RS03430	COG1862	Preprotein translocase
A6J82_RS03435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6J82_RS03440	COG4589	Belongs to the CDS family
A6J82_RS03455	COG1388	LysM domain
A6J82_RS03455	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J82_RS03460	COG2176	DNA-directed DNA polymerase activity
A6J82_RS03500	COG1028	Short-chain dehydrogenase reductase Sdr
A6J82_RS03515	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6J82_RS03520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J82_RS03525	COG3715	PTS system
A6J82_RS03530	COG3716	PTS system mannose fructose sorbose family IID component
A6J82_RS03540	COG1609	Transcriptional regulator
A6J82_RS03570	COG3590	peptidase
A6J82_RS03575	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J82_RS03585	COG4974	Belongs to the 'phage' integrase family
A6J82_RS03595	COG2946	Replication initiation factor
A6J82_RS03625	COG3177	Filamentation induced by cAMP protein fic
A6J82_RS03660	COG0450	alkyl hydroperoxide reductase
A6J82_RS03670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J82_RS03680	COG4463	regulation of RNA biosynthetic process
A6J82_RS03685	COG0542	response to heat
A6J82_RS03695	COG1428	Deoxynucleoside kinase
A6J82_RS03700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J82_RS03705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6J82_RS03735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J82_RS03785	COG1609	Transcriptional regulator
A6J82_RS03795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J82_RS03800	COG3775	system Galactitol-specific IIC component
A6J82_RS03810	COG1070	Carbohydrate kinase
A6J82_RS03830	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A6J82_RS03840	COG3448	diguanylate cyclase activity
A6J82_RS03840	COG4175	Glycine betaine
A6J82_RS03865	COG1674	ftsk spoiiie
A6J82_RS03875	COG2946	Replication initiation factor
A6J82_RS03905	COG0741	lytic transglycosylase activity
A6J82_RS03905	COG0791	NLP P60 protein
A6J82_RS04000	COG3314	Sporulation integral membrane protein YlbJ
A6J82_RS04010	COG5433	transposase activity
A6J82_RS04015	COG0745	RESPONSE REGULATOR receiver
A6J82_RS04020	COG5002	protein histidine kinase activity
A6J82_RS04035	COG1696	Membrane protein involved in D-alanine export
A6J82_RS04040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J82_RS04045	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6J82_RS04070	COG0084	hydrolase, TatD family'
A6J82_RS04085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J82_RS04095	COG1162	GTPase activity
A6J82_RS04120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J82_RS04140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J82_RS04150	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6J82_RS04155	COG0126	phosphoglycerate kinase activity
A6J82_RS04170	COG0789	Transcriptional regulator
A6J82_RS04175	COG0174	glutamine synthetase
A6J82_RS04180	COG3942	CHAP domain
A6J82_RS04195	COG1214	PFAM Peptidase M22, glycoprotease
A6J82_RS04200	COG0456	acetyltransferase
A6J82_RS04205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6J82_RS04230	COG2081	HI0933 family
A6J82_RS04245	COG0789	Transcriptional regulator
A6J82_RS04250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J82_RS04255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6J82_RS04280	COG1252	NADH dehydrogenase
A6J82_RS04285	COG1271	oxidase subunit
A6J82_RS04290	COG1294	oxidase, subunit
A6J82_RS04295	COG4988	ABC transporter
A6J82_RS04300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6J82_RS04305	COG0142	geranyltranstransferase activity
A6J82_RS04315	COG2936	dipeptidyl-peptidase activity
A6J82_RS04320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J82_RS04325	COG2814	Major facilitator Superfamily
A6J82_RS04335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J82_RS04350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J82_RS04355	COG3576	pyridoxamine 5-phosphate
A6J82_RS04360	COG1882	Formate acetyltransferase
A6J82_RS04370	COG3344	reverse transcriptase
A6J82_RS04385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J82_RS04390	COG0681	Belongs to the peptidase S26 family
A6J82_RS04395	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J82_RS04410	COG1193	negative regulation of DNA recombination
A6J82_RS04420	COG3118	belongs to the thioredoxin family
A6J82_RS04430	COG1194	a g-specific adenine glycosylase
A6J82_RS04435	COG0360	Binds together with S18 to 16S ribosomal RNA
A6J82_RS04440	COG0629	single-stranded DNA binding
A6J82_RS04470	COG2814	Major facilitator Superfamily
A6J82_RS04480	COG0006	proline dipeptidase activity
A6J82_RS04485	COG2131	deaminase
A6J82_RS04495	COG1021	2,3-dihydroxybenzoate-AMP ligase
A6J82_RS04525	COG1132	(ABC) transporter
A6J82_RS04530	COG1132	(ABC) transporter
A6J82_RS04545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J82_RS04555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J82_RS04560	COG1609	Transcriptional regulator
A6J82_RS04565	COG1621	beta-fructofuranosidase activity
A6J82_RS04570	COG1263	PTS System
A6J82_RS04570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J82_RS04570	COG2190	(PTS) system
A6J82_RS04575	COG1940	carbohydrate kinase activity
A6J82_RS04580	COG1482	cell wall glycoprotein biosynthetic process
A6J82_RS04585	COG5433	transposase activity
A6J82_RS04595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J82_RS04600	COG0736	holo-[acyl-carrier-protein] synthase activity
A6J82_RS04610	COG3942	CHAP domain
A6J82_RS04610	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J82_RS04615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J82_RS04620	COG4989	oxidoreductase activity
A6J82_RS04630	COG0252	asparaginase activity
A6J82_RS04635	COG0561	phosphatase activity
A6J82_RS04640	COG0589	response to stress
A6J82_RS04645	COG0436	Aminotransferase
A6J82_RS04650	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A6J82_RS04655	COG1335	isochorismatase
A6J82_RS04665	COG0517	IMP dehydrogenase activity
A6J82_RS04670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6J82_RS04675	COG0574	Belongs to the PEP-utilizing enzyme family
A6J82_RS04675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J82_RS04680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6J82_RS04685	COG0154	amidase activity
A6J82_RS04690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6J82_RS04700	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A6J82_RS04705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J82_RS04710	COG1534	Rna-binding protein
A6J82_RS04715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6J82_RS04720	COG1713	HD superfamily hydrolase involved in NAD metabolism
A6J82_RS04730	COG0799	negative regulation of ribosome biogenesis
A6J82_RS04735	COG2226	methyltransferase
A6J82_RS04745	COG1323	Belongs to the UPF0348 family
A6J82_RS04750	COG0789	Transcriptional regulator
A6J82_RS04760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J82_RS04765	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A6J82_RS04770	COG1461	Dihydroxyacetone kinase
A6J82_RS04775	COG2376	Dihydroxyacetone kinase
A6J82_RS04785	COG1309	transcriptional regulator
A6J82_RS04790	COG2376	Dihydroxyacetone kinase
A6J82_RS04800	COG0217	transcriptional regulatory protein
A6J82_RS04810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6J82_RS04815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J82_RS04845	COG1063	alcohol dehydrogenase
A6J82_RS04850	COG1114	Component of the transport system for branched-chain amino acids
A6J82_RS04855	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6J82_RS04865	COG1122	ATPase activity
A6J82_RS04875	COG0569	domain protein
A6J82_RS04880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J82_RS04885	COG0357	Ribosomal RNA small subunit methyltransferase G
A6J82_RS04890	COG1704	LemA family
A6J82_RS04895	COG0501	Belongs to the peptidase M48B family
A6J82_RS04905	COG0745	RESPONSE REGULATOR receiver
A6J82_RS04910	COG5002	protein histidine kinase activity
A6J82_RS04925	COG1484	DNA-dependent DNA replication
A6J82_RS04950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J82_RS04960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J82_RS04975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J82_RS04980	COG0765	amino acid transport
A6J82_RS04985	COG0706	membrane insertase activity
A6J82_RS04990	COG1254	Belongs to the acylphosphatase family
A6J82_RS04995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J82_RS05010	COG1827	regulation of RNA biosynthetic process
A6J82_RS05025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J82_RS05045	COG0582	viral genome integration into host DNA
A6J82_RS05050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6J82_RS05060	COG1187	pseudouridine synthase activity
A6J82_RS05075	COG0569	domain protein
A6J82_RS05080	COG0531	amino acid
A6J82_RS05090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6J82_RS05095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6J82_RS05135	COG0517	IMP dehydrogenase activity
A6J82_RS05145	COG0470	DNA polymerase III
A6J82_RS05165	COG3344	reverse transcriptase
A6J82_RS05185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6J82_RS05195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J82_RS05200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J82_RS05205	COG1393	Belongs to the ArsC family
A6J82_RS05215	COG0708	Exodeoxyribonuclease III
A6J82_RS05225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J82_RS05250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J82_RS05250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J82_RS05255	COG1114	Component of the transport system for branched-chain amino acids
A6J82_RS05260	COG3344	reverse transcriptase
A6J82_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
A6J82_RS05325	COG0673	inositol 2-dehydrogenase activity
A6J82_RS05360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J82_RS05385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J82_RS05390	COG1674	ftsk spoiiie
A6J82_RS05395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J82_RS05405	COG0583	DNA-binding transcription factor activity
A6J82_RS05410	COG1473	amidohydrolase
A6J82_RS05430	COG0081	regulation of translation
A6J82_RS05435	COG0747	negative chemotaxis
A6J82_RS05445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J82_RS05450	COG0444	Belongs to the ABC transporter superfamily
A6J82_RS05465	COG0233	cytoplasmic translational termination
A6J82_RS05490	COG1702	phosphate starvation-inducible protein PhoH
A6J82_RS05520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6J82_RS05525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J82_RS05580	COG1396	sequence-specific DNA binding
A6J82_RS05585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6J82_RS05595	COG1131	(ABC) transporter
A6J82_RS05605	COG2814	Major facilitator Superfamily
A6J82_RS05620	COG0557	exoribonuclease II activity
A6J82_RS05625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J82_RS05630	COG1113	amino acid transport
A6J82_RS05635	COG0463	Glycosyl transferase, family 2
A6J82_RS05640	COG0346	lactoylglutathione lyase activity
A6J82_RS05645	COG0778	Nitroreductase
A6J82_RS05650	COG0656	L-ascorbic acid biosynthetic process
A6J82_RS05655	COG1187	pseudouridine synthase activity
A6J82_RS05660	COG0154	amidase activity
A6J82_RS05670	COG2309	aminopeptidase activity
A6J82_RS05695	COG1126	abc transporter atp-binding protein
A6J82_RS05700	COG0765	amino acid transport
A6J82_RS05730	COG1442	glycosyl transferase family 8
A6J82_RS05735	COG1442	glycosyl transferase family 8
A6J82_RS05735	COG1216	Glycosyl transferase, family 2
A6J82_RS05740	COG1442	glycosyl transferase family 8
A6J82_RS05745	COG1216	Glycosyl transferase, family 2
A6J82_RS05745	COG1442	glycosyl transferase family 8
A6J82_RS05750	COG1442	glycosyl transferase family 8
A6J82_RS05755	COG0201	protein transport
A6J82_RS05780	COG0438	transferase activity, transferring glycosyl groups
A6J82_RS05800	COG3104	oligopeptide transport
A6J82_RS05805	COG3833	ABC-type maltose transport systems, permease component
A6J82_RS05810	COG1175	transmembrane transport
A6J82_RS05820	COG1609	Transcriptional regulator
A6J82_RS05825	COG1640	4-alpha-glucanotransferase
A6J82_RS05830	COG0058	SHG alpha-glucan phosphorylase activity
A6J82_RS05845	COG2271	Major facilitator Superfamily
A6J82_RS05855	COG1054	Belongs to the UPF0176 family
A6J82_RS05865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J82_RS05880	COG1970	mechanosensitive ion channel activity
A6J82_RS05885	COG0358	DNA primase activity
A6J82_RS05890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J82_RS05895	COG2151	metal-sulfur cluster biosynthetic enzyme
A6J82_RS05900	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6J82_RS05910	COG1215	transferase activity, transferring glycosyl groups
A6J82_RS05915	COG0463	Glycosyl transferase, family 2
A6J82_RS05930	COG3475	LICD family
A6J82_RS05970	COG0297	glycogen (starch) synthase activity
A6J82_RS06020	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A6J82_RS06025	COG0671	phosphoesterase, PA-phosphatase related
A6J82_RS06030	COG1242	4 iron, 4 sulfur cluster binding
A6J82_RS06035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6J82_RS06040	COG1253	flavin adenine dinucleotide binding
A6J82_RS06045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J82_RS06060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J82_RS06065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J82_RS06070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J82_RS06075	COG1120	ATPase activity
A6J82_RS06080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J82_RS06085	COG2244	polysaccharide biosynthetic process
A6J82_RS06110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6J82_RS06115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6J82_RS06125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6J82_RS06130	COG1368	sulfuric ester hydrolase activity
A6J82_RS06135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J82_RS06150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6J82_RS06155	COG3679	Belongs to the UPF0342 family
A6J82_RS06160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J82_RS06170	COG1104	cysteine desulfurase activity
A6J82_RS06175	COG0301	tRNA thio-modification
A6J82_RS06195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6J82_RS06200	COG0583	DNA-binding transcription factor activity
A6J82_RS06210	COG0564	pseudouridine synthase activity
A6J82_RS06220	COG0505	Belongs to the CarA family
A6J82_RS06230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J82_RS06235	COG1136	(ABC) transporter
A6J82_RS06240	COG0577	efflux transmembrane transporter activity
A6J82_RS06245	COG0228	four-way junction DNA binding
A6J82_RS06250	COG1837	Belongs to the UPF0109 family
A6J82_RS06305	COG1349	DNA-binding transcription factor activity
A6J82_RS06310	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J82_RS06315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J82_RS06315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J82_RS06315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J82_RS06330	COG5433	transposase activity
A6J82_RS06350	COG0488	(ABC) transporter
A6J82_RS06365	COG1132	(ABC) transporter
A6J82_RS06375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J82_RS06380	COG0242	peptide deformylase activity
A6J82_RS06385	COG0737	Belongs to the 5'-nucleotidase family
A6J82_RS06400	COG1132	(ABC) transporter
A6J82_RS06405	COG2357	RelA SpoT domain protein
A6J82_RS06410	COG0745	RESPONSE REGULATOR receiver
A6J82_RS06455	COG1272	protein, Hemolysin III
A6J82_RS06470	COG3425	synthase
A6J82_RS06480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6J82_RS06525	COG2040	homocysteine
A6J82_RS06570	COG1674	ftsk spoiiie
A6J82_RS06600	COG4974	Belongs to the 'phage' integrase family
A6J82_RS06610	COG2176	DNA-directed DNA polymerase activity
A6J82_RS06630	COG5433	transposase activity
A6J82_RS06635	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J82_RS06675	COG0534	Mate efflux family protein
A6J82_RS06685	COG0322	excinuclease ABC activity
A6J82_RS06690	COG0584	glycerophosphoryl diester phosphodiesterase
A6J82_RS06700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J82_RS06705	COG1573	uracil-dna glycosylase
A6J82_RS06745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J82_RS06760	COG0300	oxidoreductase activity
A6J82_RS06765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6J82_RS06765	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6J82_RS06790	COG2384	SAM-dependent methyltransferase
A6J82_RS06800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J82_RS06805	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6J82_RS06815	COG1088	dTDP-glucose 4,6-dehydratase activity
A6J82_RS06825	COG5492	domain, Protein
A6J82_RS06830	COG1051	belongs to the nudix hydrolase family
A6J82_RS06840	COG0628	permease
A6J82_RS06845	COG0457	Tetratricopeptide repeat
A6J82_RS06850	COG0028	Belongs to the TPP enzyme family
A6J82_RS06855	COG3527	Alpha-acetolactate decarboxylase
A6J82_RS06860	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A6J82_RS06875	COG3842	ATPase activity
A6J82_RS06895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6J82_RS06910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6J82_RS06920	COG5433	transposase activity
A6J82_RS06945	COG1316	TRANSCRIPTIONal
A6J82_RS06970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6J82_RS06985	COG1216	Glycosyl transferase, family 2
A6J82_RS06985	COG1442	glycosyl transferase family 8
A6J82_RS06990	COG1216	Glycosyl transferase, family 2
A6J82_RS06990	COG1442	glycosyl transferase family 8
A6J82_RS07015	COG2089	acid synthase
A6J82_RS07030	COG1083	cytidylyl-transferase
A6J82_RS07030	COG2755	lipolytic protein G-D-S-L family
A6J82_RS07040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J82_RS07045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6J82_RS07050	COG0187	DNA topoisomerase II activity
A6J82_RS07060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J82_RS07080	COG0539	negative regulation of cytoplasmic translation
A6J82_RS07095	COG4974	Belongs to the 'phage' integrase family
A6J82_RS07130	COG1346	cytolysis
A6J82_RS07140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J82_RS07145	COG1115	amino acid carrier protein
A6J82_RS07170	COG2261	transglycosylase associated protein
A6J82_RS07250	COG1012	belongs to the aldehyde dehydrogenase family
A6J82_RS07260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J82_RS07265	COG3344	reverse transcriptase
A6J82_RS07275	COG0726	polysaccharide deacetylase
A6J82_RS07290	COG2962	Rard protein
A6J82_RS07295	COG0285	dihydrofolate synthase activity
A6J82_RS07315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J82_RS07320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6J82_RS07330	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J82_RS07335	COG1177	transmembrane transport
A6J82_RS07345	COG0038	chloride channel
A6J82_RS07360	COG0561	phosphatase activity
A6J82_RS07375	COG0628	permease
A6J82_RS07395	COG1104	cysteine desulfurase activity
A6J82_RS07410	COG2357	RelA SpoT domain protein
A6J82_RS07415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6J82_RS07420	COG0564	pseudouridine synthase activity
A6J82_RS07425	COG0280	phosphate acetyltransferase
A6J82_RS07430	COG4221	oxidoreductase activity
A6J82_RS07445	COG0477	Major facilitator Superfamily
A6J82_RS07450	COG0516	GMP reductase activity
A6J82_RS07460	COG2233	PERMEase
A6J82_RS07470	COG3976	FMN-binding domain protein
A6J82_RS07470	COG1053	succinate dehydrogenase
A6J82_RS07470	COG0431	NADPH-dependent FMN reductase
A6J82_RS07490	COG1942	4-Oxalocrotonate Tautomerase
A6J82_RS07500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J82_RS07505	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J82_RS07515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6J82_RS07535	COG1132	(ABC) transporter
A6J82_RS07555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J82_RS07560	COG4684	Psort location CytoplasmicMembrane, score
A6J82_RS07565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J82_RS07575	COG0095	Lipoate-protein ligase
A6J82_RS07610	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6J82_RS07615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J82_RS07625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J82_RS07635	COG0488	(ABC) transporter
A6J82_RS07645	COG0284	orotidine-5'-phosphate decarboxylase activity
A6J82_RS07650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6J82_RS07655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6J82_RS07665	COG0505	Belongs to the CarA family
A6J82_RS07815	COG3275	phosphorelay sensor kinase activity
A6J82_RS07820	COG3279	Response regulator of the LytR AlgR family
A6J82_RS07825	COG1966	Carbon starvation protein
A6J82_RS07830	COG1376	ErfK ybiS ycfS ynhG family protein
A6J82_RS07835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J82_RS07845	COG0110	maltose O-acetyltransferase activity
A6J82_RS07850	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J82_RS07855	COG4605	iron ion homeostasis
A6J82_RS07860	COG4604	ABC transporter, ATP-binding protein
A6J82_RS07865	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A6J82_RS07870	COG0758	DNA mediated transformation
A6J82_RS07875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J82_RS07880	COG1136	(ABC) transporter
A6J82_RS07910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6J82_RS07915	COG0196	riboflavin kinase activity
A6J82_RS07925	COG4476	Belongs to the UPF0223 family
A6J82_RS07930	COG0483	inositol monophosphate 1-phosphatase activity
A6J82_RS07935	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6J82_RS07935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J82_RS07945	COG0573	inorganic phosphate transmembrane transporter activity
A6J82_RS07950	COG0581	inorganic phosphate transmembrane transporter activity
A6J82_RS07955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J82_RS07960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J82_RS07965	COG0704	Plays a role in the regulation of phosphate uptake
A6J82_RS07975	COG0745	RESPONSE REGULATOR receiver
A6J82_RS07980	COG5002	protein histidine kinase activity
A6J82_RS07985	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A6J82_RS07990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J82_RS08005	COG4166	transmembrane transport
A6J82_RS08010	COG4974	Belongs to the 'phage' integrase family
A6J82_RS08015	COG5002	protein histidine kinase activity
A6J82_RS08020	COG0745	RESPONSE REGULATOR receiver
A6J82_RS08030	COG1136	(ABC) transporter
A6J82_RS08045	COG1464	Belongs to the NlpA lipoprotein family
A6J82_RS08055	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6J82_RS08060	COG2188	Transcriptional regulator
A6J82_RS08085	COG3344	reverse transcriptase
A6J82_RS08090	COG0346	lactoylglutathione lyase activity
A6J82_RS08095	COG3764	Sortase (surface protein transpeptidase)
A6J82_RS08115	COG1079	Belongs to the binding-protein-dependent transport system permease family
A6J82_RS08120	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6J82_RS08125	COG3845	ABC transporter
A6J82_RS08130	COG1744	ABC transporter substrate-binding protein PnrA-like
A6J82_RS08140	COG2813	Specifically methylates the guanine in position
A6J82_RS08145	COG1072	(Pantothenic acid kinase))
A6J82_RS08160	COG1126	abc transporter atp-binding protein
A6J82_RS08165	COG0765	amino acid transport
A6J82_RS08170	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J82_RS08175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6J82_RS08190	COG0469	pyruvate kinase activity
A6J82_RS08195	COG0205	6-phosphofructokinase activity
A6J82_RS08205	COG1725	Transcriptional regulator
A6J82_RS08210	COG1131	(ABC) transporter
A6J82_RS08250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J82_RS08260	COG0456	acetyltransferase
A6J82_RS08265	COG1418	mRNA catabolic process
A6J82_RS08275	COG0481	GTPase activity
A6J82_RS08300	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A6J82_RS08305	COG1518	maintenance of DNA repeat elements
A6J82_RS08310	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A6J82_RS08320	COG0647	UMP catabolic process
A6J82_RS08330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J82_RS08355	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A6J82_RS08360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J82_RS08365	COG3442	glutamine amidotransferase
A6J82_RS08370	COG3344	reverse transcriptase
A6J82_RS08380	COG0095	Lipoate-protein ligase
A6J82_RS08390	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J82_RS08395	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J82_RS08395	COG0022	dehydrogenase e1 component
A6J82_RS08400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6J82_RS08405	COG0488	(ABC) transporter
A6J82_RS08410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J82_RS08420	COG1074	ATP-dependent DNA helicase activity
A6J82_RS08425	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A6J82_RS08430	COG2321	neutral zinc metallopeptidase
A6J82_RS08445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J82_RS08445	COG0072	phenylalanine-tRNA ligase activity
A6J82_RS08470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J82_RS08525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J82_RS08530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J82_RS08540	COG1523	belongs to the glycosyl hydrolase 13 family
A6J82_RS08545	COG1597	lipid kinase activity
A6J82_RS08550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J82_RS08555	COG4708	membrane
A6J82_RS08560	COG2246	polysaccharide biosynthetic process
A6J82_RS08570	COG0024	Methionine aminopeptidase
A6J82_RS08575	COG4109	DRTGG domain
A6J82_RS08585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J82_RS08595	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6J82_RS08605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6J82_RS08615	COG1122	ATPase activity
A6J82_RS08620	COG4721	ABC-type cobalt transport system, permease component
A6J82_RS08650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6J82_RS08655	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6J82_RS08655	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6J82_RS08665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J82_RS08670	COG1956	GAF domain-containing protein
A6J82_RS08675	COG5433	transposase activity
A6J82_RS08685	COG0513	Belongs to the DEAD box helicase family
A6J82_RS08700	COG0726	polysaccharide deacetylase
A6J82_RS08705	COG1012	belongs to the aldehyde dehydrogenase family
A6J82_RS08720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J82_RS08725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J82_RS08730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J82_RS08745	COG1476	TRANSCRIPTIONal
A6J82_RS08755	COG1442	glycosyl transferase family 8
A6J82_RS08770	COG4894	glucomannan catabolic process
A6J82_RS08780	COG4122	O-methyltransferase activity
A6J82_RS08785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J82_RS08810	COG1187	pseudouridine synthase activity
A6J82_RS08815	COG0435	Glutathione S-transferase
A6J82_RS08820	COG0363	glucosamine-6-phosphate deaminase activity
A6J82_RS08830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6J82_RS08835	COG1846	Transcriptional regulator
A6J82_RS08845	COG2610	gluconate transmembrane transporter activity
A6J82_RS08850	COG1929	Belongs to the glycerate kinase type-1 family
A6J82_RS08855	COG3835	regulator
A6J82_RS08865	COG2190	(PTS) system
A6J82_RS08865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J82_RS08865	COG1263	PTS System
A6J82_RS08870	COG3711	transcriptional antiterminator
A6J82_RS08875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J82_RS08890	COG0657	acetylesterase activity
A6J82_RS08895	COG1609	Transcriptional regulator
A6J82_RS08900	COG0561	phosphatase activity
A6J82_RS08905	COG0658	competence protein
A6J82_RS08905	COG2333	competence protein COMEC
A6J82_RS08910	COG1555	photosystem II stabilization
A6J82_RS08910	COG1596	polysaccharide export
A6J82_RS08915	COG0204	Acyl-transferase
A6J82_RS08920	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6J82_RS08930	COG0513	Belongs to the DEAD box helicase family
A6J82_RS08935	COG1464	Belongs to the NlpA lipoprotein family
A6J82_RS08940	COG2011	ABC-type metal ion transport system permease component
A6J82_RS08945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J82_RS08975	COG2223	nitrite transmembrane transporter activity
A6J82_RS08980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J82_RS08995	COG0768	penicillin binding
A6J82_RS09015	COG0772	Belongs to the SEDS family
A6J82_RS09025	COG1164	Oligoendopeptidase f
A6J82_RS09050	COG3344	reverse transcriptase
A6J82_RS09060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6J82_RS09085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J82_RS09085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J82_RS09100	COG1914	H( )-stimulated, divalent metal cation uptake system
A6J82_RS09110	COG4443	Transcriptional Coactivator p15 (PC4)
A6J82_RS09115	COG0826	peptidase U32
A6J82_RS09155	COG1983	PspC domain protein
A6J82_RS09160	COG3091	SprT-like family
A6J82_RS09165	COG2183	response to ionizing radiation
A6J82_RS09180	COG0701	Predicted permease
A6J82_RS09185	COG3689	TIGRFAM TIGR03943 family protein
A6J82_RS09190	COG3344	reverse transcriptase
A6J82_RS09200	COG0552	protein localization to endoplasmic reticulum
A6J82_RS09205	COG0561	phosphatase activity
A6J82_RS09210	COG0561	phosphatase activity
A6J82_RS09215	COG5433	transposase activity
A6J82_RS09220	COG1196	nuclear chromosome segregation
A6J82_RS09230	COG2832	Protein of unknown function (DUF454)
A6J82_RS09235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6J82_RS09240	COG5002	protein histidine kinase activity
A6J82_RS09245	COG0745	RESPONSE REGULATOR receiver
A6J82_RS09250	COG1126	abc transporter atp-binding protein
A6J82_RS09255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J82_RS09260	COG0765	amino acid transport
A6J82_RS09265	COG0765	amino acid transport
A6J82_RS09290	COG0438	transferase activity, transferring glycosyl groups
A6J82_RS09305	COG1609	Transcriptional regulator
A6J82_RS09320	COG3344	reverse transcriptase
A6J82_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
A6J82_RS09350	COG0800	Aldolase
A6J82_RS09355	COG2186	Transcriptional regulator
A6J82_RS09360	COG3250	beta-galactosidase activity
A6J82_RS09370	COG2211	Major facilitator Superfamily
A6J82_RS09385	COG0583	DNA-binding transcription factor activity
A6J82_RS09395	COG0390	transport system, permease component
A6J82_RS09400	COG4619	ABC transporter
A6J82_RS09405	COG0586	Pfam SNARE associated Golgi protein
A6J82_RS09420	COG1136	(ABC) transporter
A6J82_RS09450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J82_RS09455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J82_RS09475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J82_RS09480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J82_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
A6J82_RS09515	COG4555	ABC transporter
A6J82_RS09520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J82_RS09570	COG0534	Mate efflux family protein
A6J82_RS09575	COG1129	ABC transporter
A6J82_RS09590	COG1132	(ABC) transporter
A6J82_RS09595	COG1132	(ABC) transporter
A6J82_RS09595	COG2375	cellular response to nickel ion
A6J82_RS09600	COG1309	transcriptional regulator
A6J82_RS09615	COG4581	dead DEAH box helicase
A6J82_RS09680	COG1120	ATPase activity
A6J82_RS09685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J82_RS09690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J82_RS09700	COG4106	trans-aconitate 2-methyltransferase activity
A6J82_RS09785	COG1316	TRANSCRIPTIONal
A6J82_RS09805	COG0148	phosphopyruvate hydratase activity
A6J82_RS09820	COG0560	Phosphoserine phosphatase
A6J82_RS09845	COG5433	transposase activity
A6J82_RS09850	COG0772	Belongs to the SEDS family
A6J82_RS09860	COG3344	reverse transcriptase
A6J82_RS09880	COG5002	protein histidine kinase activity
A6J82_RS09895	COG1136	(ABC) transporter
A6J82_RS10205	COG3561	AntA/AntB antirepressor
A6J82_RS10240	COG1396	sequence-specific DNA binding
A6J82_RS10255	COG0582	viral genome integration into host DNA
A6J82_RS10265	COG0335	large ribosomal subunit rRNA binding
A6J82_RS10270	COG0038	chloride channel
A6J82_RS10275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6J82_RS10275	COG1605	Chorismate mutase
A6J82_RS10280	COG0716	FMN binding
A6J82_RS10285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6J82_RS10290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J82_RS10295	COG0254	rRNA binding
A6J82_RS10305	COG3344	reverse transcriptase
A6J82_RS10330	COG1660	Displays ATPase and GTPase activities
A6J82_RS10355	COG0017	Asparaginyl-tRNA synthetase
A6J82_RS10360	COG0436	Aminotransferase
A6J82_RS10365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J82_RS10365	COG1199	ATP-dependent helicase activity
A6J82_RS10380	COG3344	reverse transcriptase
A6J82_RS10400	COG2177	Part of the ABC transporter FtsEX involved in
A6J82_RS10405	COG2884	Cell division ATP-binding protein ftsE
A6J82_RS10415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J82_RS10440	COG1078	dGTPase activity
A6J82_RS10495	COG2755	lipolytic protein G-D-S-L family
A6J82_RS10500	COG1307	EDD domain protein, DegV family
A6J82_RS10505	COG0497	DNA recombination
A6J82_RS10510	COG1438	arginine binding
A6J82_RS10515	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6J82_RS10525	COG1722	exodeoxyribonuclease VII activity
A6J82_RS10530	COG1570	exodeoxyribonuclease VII activity
A6J82_RS10535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6J82_RS10545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J82_RS10550	COG1126	abc transporter atp-binding protein
A6J82_RS10555	COG0765	amino acid transport
A6J82_RS10560	COG4703	Protein of unknown function (DUF1797)
A6J82_RS10570	COG0542	response to heat
A6J82_RS10575	COG0494	nUDIX hydrolase
A6J82_RS10585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J82_RS10590	COG3599	regulation of cell shape
A6J82_RS10595	COG2302	S4 RNA-binding domain
A6J82_RS10600	COG0762	integral membrane protein
A6J82_RS10610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J82_RS10635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6J82_RS10645	COG1217	gtp-binding protein TYPA
A6J82_RS10650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J82_RS10655	COG1940	carbohydrate kinase activity
A6J82_RS10670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J82_RS10690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J82_RS10695	COG1268	BioY protein
A6J82_RS10705	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J82_RS10710	COG1132	(ABC) transporter
A6J82_RS10715	COG1132	(ABC) transporter
A6J82_RS10725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J82_RS10730	COG4470	Protein conserved in bacteria
A6J82_RS10735	COG0737	Belongs to the 5'-nucleotidase family
A6J82_RS10740	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6J82_RS10755	COG0742	ribosomal rna small subunit methyltransferase
A6J82_RS10770	COG2315	Protein conserved in bacteria
A6J82_RS10780	COG0673	inositol 2-dehydrogenase activity
A6J82_RS10795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J82_RS10850	COG0656	L-ascorbic acid biosynthetic process
A6J82_RS10860	COG0789	Transcriptional regulator
A6J82_RS10870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J82_RS10925	COG1216	Glycosyl transferase, family 2
A6J82_RS10925	COG1442	glycosyl transferase family 8
A6J82_RS10935	COG2153	protein acetylation
A6J82_RS10945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J82_RS10950	COG2137	regulation of response to DNA damage stimulus
A6J82_RS11020	COG0706	membrane insertase activity
A6J82_RS11035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6J82_RS11050	COG1744	ABC transporter substrate-binding protein PnrA-like
A6J82_RS11055	COG0457	Tetratricopeptide repeat
A6J82_RS11055	COG0705	Rhomboid family
A6J82_RS11060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J82_RS11065	COG0166	Belongs to the GPI family
A6J82_RS11080	COG1234	tRNA 3'-trailer cleavage
A6J82_RS11085	COG1268	BioY protein
A6J82_RS11105	COG5002	protein histidine kinase activity
A6J82_RS11125	COG3344	reverse transcriptase
A6J82_RS11135	COG1832	CoA-binding protein
A6J82_RS11140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J82_RS11140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J82_RS11150	COG2860	membrane
A6J82_RS11175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6J82_RS11180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6J82_RS11190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6J82_RS11195	COG0195	Participates in both transcription termination and antitermination
A6J82_RS11210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J82_RS11220	COG4473	ABC transporter
A6J82_RS11225	COG1131	(ABC) transporter
A6J82_RS11240	COG0537	adenosine 5'-monophosphoramidase activity
A6J82_RS11250	COG1316	TRANSCRIPTIONal
A6J82_RS11260	COG0802	atpase or kinase
A6J82_RS11265	COG2252	PERMEase
A6J82_RS11280	COG0561	phosphatase activity
A6J82_RS11295	COG3715	PTS system
A6J82_RS11300	COG3716	PTS system mannose fructose sorbose family IID component
A6J82_RS11320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6J82_RS11350	COG0439	Biotin carboxylase
A6J82_RS11365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J82_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
A6J82_RS11375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J82_RS11380	COG2070	2-Nitropropane dioxygenase
A6J82_RS11390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J82_RS11400	COG1024	Enoyl-CoA hydratase
A6J82_RS11410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J82_RS11415	COG0527	aspartate kinase activity
A6J82_RS11450	COG1040	competence protein
A6J82_RS11455	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A6J82_RS11460	COG1739	Uncharacterized protein family UPF0029
A6J82_RS11480	COG1882	Formate acetyltransferase
A6J82_RS11485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J82_RS11495	COG1447	Phosphotransferase system cellobiose-specific component IIA