locus-tag	class	description
DK42_RS00010	COG0592	DNA-directed DNA polymerase activity
DK42_RS00035	COG0012	GTP binding
DK42_RS00045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DK42_RS00050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DK42_RS00080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DK42_RS00265	COG0436	Aminotransferase
DK42_RS00285	COG0416	fatty acid biosynthetic process
DK42_RS00290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DK42_RS00295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DK42_RS00300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DK42_RS00315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DK42_RS00320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DK42_RS00330	COG0138	bifunctional purine biosynthesis protein purh
DK42_RS00355	COG1175	transmembrane transport
DK42_RS00360	COG0395	ABC-type sugar transport system, permease component
DK42_RS00375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DK42_RS00385	COG3458	cephalosporin-C deacetylase activity
DK42_RS00400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DK42_RS00430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DK42_RS00445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DK42_RS00455	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DK42_RS00455	COG2755	lipolytic protein G-D-S-L family
DK42_RS00460	COG1012	belongs to the aldehyde dehydrogenase family
DK42_RS00460	COG1454	alcohol dehydrogenase
DK42_RS00465	COG1064	alcohol dehydrogenase
DK42_RS00475	COG0534	Mate efflux family protein
DK42_RS00585	COG0201	protein transport
DK42_RS00590	COG0563	adenylate kinase activity
DK42_RS00600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DK42_RS00610	COG0202	RNA polymerase activity
DK42_RS00735	COG3344	reverse transcriptase
DK42_RS00755	COG1705	Flagellar rod assembly protein muramidase FlgJ
DK42_RS00770	COG0443	Heat shock 70 kDa protein
DK42_RS00780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DK42_RS00785	COG0101	tRNA pseudouridine synthase activity
DK42_RS00790	COG0351	phosphomethylpyrimidine kinase
DK42_RS00795	COG4720	Psort location CytoplasmicMembrane, score
DK42_RS00805	COG0668	transmembrane transport
DK42_RS00835	COG0756	dUTP diphosphatase activity
DK42_RS00850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DK42_RS00855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DK42_RS00860	COG1879	ABC-type sugar transport system periplasmic component
DK42_RS00865	COG1172	Belongs to the binding-protein-dependent transport system permease family
DK42_RS00880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DK42_RS00885	COG1609	Transcriptional regulator
DK42_RS00890	COG0577	efflux transmembrane transporter activity
DK42_RS00895	COG1136	(ABC) transporter
DK42_RS00900	COG0745	RESPONSE REGULATOR receiver
DK42_RS00905	COG5002	protein histidine kinase activity
DK42_RS00920	COG0191	fructose-bisphosphate aldolase activity
DK42_RS00940	COG1461	Dihydroxyacetone kinase
DK42_RS00960	COG1126	abc transporter atp-binding protein
DK42_RS00965	COG0765	amino acid transport
DK42_RS00985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DK42_RS00990	COG3344	reverse transcriptase
DK42_RS01005	COG0719	Fe-S assembly protein
DK42_RS01010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DK42_RS01020	COG0719	Fe-S assembly protein
DK42_RS01025	COG1686	Belongs to the peptidase S11 family
DK42_RS01030	COG1686	Belongs to the peptidase S11 family
DK42_RS01035	COG4166	transmembrane transport
DK42_RS01040	COG0601	transmembrane transport
DK42_RS01045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DK42_RS01050	COG0444	Belongs to the ABC transporter superfamily
DK42_RS01055	COG4608	Belongs to the ABC transporter superfamily
DK42_RS01095	COG1121	(ABC) transporter
DK42_RS01100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DK42_RS01110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DK42_RS01115	COG4499	WXG100 protein secretion system (Wss), protein YukC
DK42_RS01115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DK42_RS01135	COG3344	reverse transcriptase
DK42_RS01145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DK42_RS01150	COG1459	type II secretion system
DK42_RS01185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DK42_RS01190	COG1363	Peptidase, m42
DK42_RS01205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DK42_RS01210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DK42_RS01225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DK42_RS01245	COG1346	cytolysis
DK42_RS01255	COG0601	transmembrane transport
DK42_RS01260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DK42_RS01265	COG1122	ATPase activity
DK42_RS01275	COG1263	PTS System
DK42_RS01275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK42_RS01280	COG0366	Alpha amylase catalytic
DK42_RS01285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DK42_RS01300	COG3959	Transketolase, thiamine diphosphate binding domain
DK42_RS01305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DK42_RS01310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DK42_RS01330	COG1045	serine acetyltransferase
DK42_RS01340	COG0215	cysteine-tRNA ligase activity
DK42_RS01345	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DK42_RS01370	COG1476	TRANSCRIPTIONal
DK42_RS01375	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DK42_RS01385	COG4974	Belongs to the 'phage' integrase family
DK42_RS01485	COG1396	sequence-specific DNA binding
DK42_RS01490	COG2814	Major facilitator Superfamily
DK42_RS01500	COG1732	Glycine betaine
DK42_RS01600	COG0519	Catalyzes the synthesis of GMP from XMP
DK42_RS01645	COG1695	Transcriptional regulator
DK42_RS01660	COG1755	Isoprenylcysteine carboxyl methyltransferase
DK42_RS01700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DK42_RS01705	COG0446	pyridine nucleotide-disulphide oxidoreductase
DK42_RS01725	COG1131	(ABC) transporter
DK42_RS01735	COG1263	PTS System
DK42_RS01735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK42_RS01735	COG2190	(PTS) system
DK42_RS01740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DK42_RS01745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DK42_RS01750	COG0275	rRNA processing
DK42_RS01760	COG0768	penicillin binding
DK42_RS01770	COG0513	Belongs to the DEAD box helicase family
DK42_RS01785	COG1126	abc transporter atp-binding protein
DK42_RS01795	COG0492	ferredoxin-NADP+ reductase activity
DK42_RS01800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DK42_RS01815	COG3579	cysteine-type endopeptidase activity
DK42_RS01820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DK42_RS01840	COG0116	Belongs to the methyltransferase superfamily
DK42_RS01850	COG1854	S-ribosylhomocysteine lyase activity
DK42_RS01855	COG1418	mRNA catabolic process
DK42_RS01855	COG4372	Transposase
DK42_RS01860	COG1131	(ABC) transporter
DK42_RS01870	COG4585	Histidine kinase
DK42_RS01875	COG2197	response regulator
DK42_RS01885	COG0194	GDP metabolic process
DK42_RS01895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DK42_RS01900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DK42_RS01905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DK42_RS01905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DK42_RS01915	COG0515	serine threonine protein kinase
DK42_RS01915	COG2815	serine threonine protein kinase
DK42_RS01925	COG4585	Histidine kinase
DK42_RS01930	COG2197	response regulator
DK42_RS01940	COG1098	S1 RNA binding domain
DK42_RS01945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DK42_RS01950	COG1349	DNA-binding transcription factor activity
DK42_RS01960	COG1447	Phosphotransferase system cellobiose-specific component IIA
DK42_RS01970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK42_RS01975	COG1882	Formate acetyltransferase
DK42_RS01995	COG1739	Uncharacterized protein family UPF0029
DK42_RS02000	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DK42_RS02005	COG1040	competence protein
DK42_RS02040	COG0527	aspartate kinase activity
DK42_RS02045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DK42_RS02050	COG1024	Enoyl-CoA hydratase
DK42_RS02060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DK42_RS02070	COG2070	2-Nitropropane dioxygenase
DK42_RS02075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DK42_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
DK42_RS02085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DK42_RS02100	COG0439	Biotin carboxylase
DK42_RS02125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DK42_RS02145	COG3716	PTS system mannose fructose sorbose family IID component
DK42_RS02150	COG3715	PTS system
DK42_RS02160	COG0561	phosphatase activity
DK42_RS02175	COG2252	PERMEase
DK42_RS02180	COG0802	atpase or kinase
DK42_RS02190	COG1316	TRANSCRIPTIONal
DK42_RS02200	COG0537	adenosine 5'-monophosphoramidase activity
DK42_RS02215	COG1131	(ABC) transporter
DK42_RS02220	COG4473	ABC transporter
DK42_RS02230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DK42_RS02245	COG0195	Participates in both transcription termination and antitermination
DK42_RS02250	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DK42_RS02260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DK42_RS02265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DK42_RS02290	COG2860	membrane
DK42_RS02300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DK42_RS02300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DK42_RS02305	COG1832	CoA-binding protein
DK42_RS02315	COG3344	reverse transcriptase
DK42_RS02330	COG5002	protein histidine kinase activity
DK42_RS02350	COG1268	BioY protein
DK42_RS02355	COG1234	tRNA 3'-trailer cleavage
DK42_RS02370	COG0166	Belongs to the GPI family
DK42_RS02375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DK42_RS02380	COG0705	Rhomboid family
DK42_RS02380	COG0457	Tetratricopeptide repeat
DK42_RS02385	COG1744	ABC transporter substrate-binding protein PnrA-like
DK42_RS02395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DK42_RS02410	COG0706	membrane insertase activity
DK42_RS02480	COG2137	regulation of response to DNA damage stimulus
DK42_RS02485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DK42_RS02495	COG2153	protein acetylation
DK42_RS02505	COG1442	glycosyl transferase family 8
DK42_RS02505	COG1216	Glycosyl transferase, family 2
DK42_RS02540	COG2801	Transposase and inactivated derivatives
DK42_RS02550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DK42_RS02560	COG0789	Transcriptional regulator
DK42_RS02570	COG0656	L-ascorbic acid biosynthetic process
DK42_RS02625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DK42_RS02640	COG0673	inositol 2-dehydrogenase activity
DK42_RS02650	COG2315	Protein conserved in bacteria
DK42_RS02665	COG0742	ribosomal rna small subunit methyltransferase
DK42_RS02680	COG3480	Lon protease (S16) C-terminal proteolytic domain
DK42_RS02685	COG0737	Belongs to the 5'-nucleotidase family
DK42_RS02690	COG4470	Protein conserved in bacteria
DK42_RS02695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DK42_RS02705	COG1132	(ABC) transporter
DK42_RS02710	COG1132	(ABC) transporter
DK42_RS02715	COG0512	Glutamine amidotransferase of anthranilate synthase
DK42_RS02720	COG1268	BioY protein
DK42_RS02725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DK42_RS02745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DK42_RS02760	COG1940	carbohydrate kinase activity
DK42_RS02765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DK42_RS02770	COG1217	gtp-binding protein TYPA
DK42_RS02780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DK42_RS02805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DK42_RS02815	COG0762	integral membrane protein
DK42_RS02820	COG2302	S4 RNA-binding domain
DK42_RS02825	COG3599	regulation of cell shape
DK42_RS02830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DK42_RS02840	COG0494	nUDIX hydrolase
DK42_RS02845	COG0542	response to heat
DK42_RS02850	COG4703	Protein of unknown function (DUF1797)
DK42_RS02855	COG3344	reverse transcriptase
DK42_RS02860	COG0765	amino acid transport
DK42_RS02865	COG1126	abc transporter atp-binding protein
DK42_RS02870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DK42_RS02880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DK42_RS02885	COG1570	exodeoxyribonuclease VII activity
DK42_RS02890	COG1722	exodeoxyribonuclease VII activity
DK42_RS02900	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DK42_RS02905	COG1438	arginine binding
DK42_RS02910	COG0497	DNA recombination
DK42_RS02915	COG1307	EDD domain protein, DegV family
DK42_RS02920	COG2755	lipolytic protein G-D-S-L family
DK42_RS02965	COG1078	dGTPase activity
DK42_RS02990	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DK42_RS03000	COG2884	Cell division ATP-binding protein ftsE
DK42_RS03005	COG2177	Part of the ABC transporter FtsEX involved in
DK42_RS03025	COG3344	reverse transcriptase
DK42_RS03030	COG1199	ATP-dependent helicase activity
DK42_RS03030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DK42_RS03035	COG0436	Aminotransferase
DK42_RS03040	COG0017	Asparaginyl-tRNA synthetase
DK42_RS03060	COG1660	Displays ATPase and GTPase activities
DK42_RS03085	COG0254	rRNA binding
DK42_RS03090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DK42_RS03095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DK42_RS03100	COG0716	FMN binding
DK42_RS03105	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DK42_RS03105	COG1605	Chorismate mutase
DK42_RS03110	COG0038	chloride channel
DK42_RS03115	COG0335	large ribosomal subunit rRNA binding
DK42_RS03125	COG0582	viral genome integration into host DNA
DK42_RS03440	COG1136	(ABC) transporter
DK42_RS03455	COG5002	protein histidine kinase activity
DK42_RS03480	COG0772	Belongs to the SEDS family
DK42_RS03485	COG5433	transposase activity
DK42_RS03505	COG0560	Phosphoserine phosphatase
DK42_RS03520	COG0148	phosphopyruvate hydratase activity
DK42_RS03540	COG1316	TRANSCRIPTIONal
DK42_RS03555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DK42_RS03570	COG1192	Involved in chromosome partitioning
DK42_RS03690	COG4509	Sortase family
DK42_RS03695	COG0791	NLP P60 protein
DK42_RS03695	COG0741	lytic transglycosylase activity
DK42_RS03710	COG1876	peptidase activity
DK42_RS03715	COG2720	vancomycin resistance protein
DK42_RS03720	COG1181	Belongs to the D-alanine--D-alanine ligase family
DK42_RS03750	COG2337	Toxic component of a toxin-antitoxin (TA) module
DK42_RS03755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DK42_RS03825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DK42_RS03825	COG0551	DNA topoisomerase type I activity
DK42_RS03860	COG4581	dead DEAH box helicase
DK42_RS03875	COG1309	transcriptional regulator
DK42_RS03880	COG2375	cellular response to nickel ion
DK42_RS03880	COG1132	(ABC) transporter
DK42_RS03885	COG1132	(ABC) transporter
DK42_RS03900	COG1129	ABC transporter
DK42_RS03905	COG0534	Mate efflux family protein
DK42_RS03940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DK42_RS03945	COG4555	ABC transporter
DK42_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
DK42_RS03975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DK42_RS03980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DK42_RS04000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DK42_RS04005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DK42_RS04035	COG1136	(ABC) transporter
DK42_RS04050	COG0586	Pfam SNARE associated Golgi protein
DK42_RS04055	COG4619	ABC transporter
DK42_RS04060	COG0390	transport system, permease component
DK42_RS04070	COG0583	DNA-binding transcription factor activity
DK42_RS04085	COG2211	Major facilitator Superfamily
DK42_RS04095	COG3250	beta-galactosidase activity
DK42_RS04100	COG2186	Transcriptional regulator
DK42_RS04105	COG0800	Aldolase
DK42_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
DK42_RS04145	COG1609	Transcriptional regulator
DK42_RS04160	COG0438	transferase activity, transferring glycosyl groups
DK42_RS04185	COG0765	amino acid transport
DK42_RS04190	COG0765	amino acid transport
DK42_RS04195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DK42_RS04200	COG1126	abc transporter atp-binding protein
DK42_RS04205	COG0745	RESPONSE REGULATOR receiver
DK42_RS04210	COG5002	protein histidine kinase activity
DK42_RS04215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DK42_RS04220	COG2832	Protein of unknown function (DUF454)
DK42_RS04230	COG1196	nuclear chromosome segregation
DK42_RS04235	COG5433	transposase activity
DK42_RS04240	COG0561	phosphatase activity
DK42_RS04245	COG0561	phosphatase activity
DK42_RS04250	COG0552	protein localization to endoplasmic reticulum
DK42_RS04260	COG3344	reverse transcriptase
DK42_RS04265	COG3689	TIGRFAM TIGR03943 family protein
DK42_RS04270	COG0701	Predicted permease
DK42_RS04285	COG2183	response to ionizing radiation
DK42_RS04290	COG3091	SprT-like family
DK42_RS04295	COG1983	PspC domain protein
DK42_RS04330	COG0826	peptidase U32
DK42_RS04335	COG4443	Transcriptional Coactivator p15 (PC4)
DK42_RS04345	COG1914	H( )-stimulated, divalent metal cation uptake system
DK42_RS04360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DK42_RS04360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DK42_RS04380	COG3344	reverse transcriptase
DK42_RS04395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DK42_RS04425	COG1164	Oligoendopeptidase f
DK42_RS04435	COG0772	Belongs to the SEDS family
DK42_RS04455	COG0768	penicillin binding
DK42_RS04470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DK42_RS04475	COG2223	nitrite transmembrane transporter activity
DK42_RS04500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DK42_RS04505	COG2011	ABC-type metal ion transport system permease component
DK42_RS04510	COG1464	Belongs to the NlpA lipoprotein family
DK42_RS04515	COG0513	Belongs to the DEAD box helicase family
DK42_RS04525	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DK42_RS04530	COG0204	Acyl-transferase
DK42_RS04535	COG1596	polysaccharide export
DK42_RS04535	COG1555	photosystem II stabilization
DK42_RS04540	COG2333	competence protein COMEC
DK42_RS04540	COG0658	competence protein
DK42_RS04545	COG0561	phosphatase activity
DK42_RS04550	COG1609	Transcriptional regulator
DK42_RS04555	COG0657	acetylesterase activity
DK42_RS04570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DK42_RS04575	COG3711	transcriptional antiterminator
DK42_RS04580	COG1263	PTS System
DK42_RS04580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK42_RS04580	COG2190	(PTS) system
DK42_RS04590	COG3835	regulator
DK42_RS04595	COG1929	Belongs to the glycerate kinase type-1 family
DK42_RS04610	COG1846	Transcriptional regulator
DK42_RS04615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DK42_RS04625	COG0363	glucosamine-6-phosphate deaminase activity
DK42_RS04630	COG0435	Glutathione S-transferase
DK42_RS04635	COG1187	pseudouridine synthase activity
DK42_RS04655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DK42_RS04660	COG4122	O-methyltransferase activity
DK42_RS04670	COG4894	glucomannan catabolic process
DK42_RS04685	COG1442	glycosyl transferase family 8
DK42_RS04695	COG1476	TRANSCRIPTIONal
DK42_RS04710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DK42_RS04715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DK42_RS04720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DK42_RS04735	COG1012	belongs to the aldehyde dehydrogenase family
DK42_RS04740	COG0726	polysaccharide deacetylase
DK42_RS04750	COG0513	Belongs to the DEAD box helicase family
DK42_RS04760	COG5433	transposase activity
DK42_RS04765	COG1956	GAF domain-containing protein
DK42_RS04770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DK42_RS04780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DK42_RS04780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DK42_RS04785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DK42_RS04810	COG4721	ABC-type cobalt transport system, permease component
DK42_RS04815	COG1122	ATPase activity
DK42_RS04825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DK42_RS04835	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DK42_RS04845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DK42_RS04855	COG4109	DRTGG domain
DK42_RS04860	COG0024	Methionine aminopeptidase
DK42_RS04870	COG2246	polysaccharide biosynthetic process
DK42_RS04875	COG4708	membrane
DK42_RS04880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DK42_RS04885	COG1597	lipid kinase activity
DK42_RS04890	COG1523	belongs to the glycosyl hydrolase 13 family
DK42_RS04900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DK42_RS04905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DK42_RS04960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DK42_RS04985	COG0072	phenylalanine-tRNA ligase activity
DK42_RS04985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DK42_RS04990	COG2321	neutral zinc metallopeptidase
DK42_RS04995	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DK42_RS05000	COG1074	ATP-dependent DNA helicase activity
DK42_RS05010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DK42_RS05015	COG0488	(ABC) transporter
DK42_RS05020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DK42_RS05025	COG0508	dehydrogenase complex catalyzes the overall conversion of
DK42_RS05025	COG0022	dehydrogenase e1 component
DK42_RS05030	COG0508	dehydrogenase complex catalyzes the overall conversion of
DK42_RS05040	COG0095	Lipoate-protein ligase
DK42_RS05050	COG3344	reverse transcriptase
DK42_RS05055	COG3442	glutamine amidotransferase
DK42_RS05060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DK42_RS05065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DK42_RS05090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DK42_RS05100	COG0647	UMP catabolic process
DK42_RS05110	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
DK42_RS05115	COG1518	maintenance of DNA repeat elements
DK42_RS05120	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DK42_RS05135	COG0481	GTPase activity
DK42_RS05145	COG1418	mRNA catabolic process
DK42_RS05150	COG0456	acetyltransferase
DK42_RS05160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DK42_RS05195	COG1131	(ABC) transporter
DK42_RS05200	COG1725	Transcriptional regulator
DK42_RS05210	COG0205	6-phosphofructokinase activity
DK42_RS05215	COG0469	pyruvate kinase activity
DK42_RS05225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DK42_RS05230	COG2824	Alkylphosphonate utilization operon protein PhnA
DK42_RS05235	COG0765	amino acid transport
DK42_RS05240	COG1126	abc transporter atp-binding protein
DK42_RS05255	COG1072	(Pantothenic acid kinase))
DK42_RS05260	COG2813	Specifically methylates the guanine in position
DK42_RS05270	COG1744	ABC transporter substrate-binding protein PnrA-like
DK42_RS05275	COG3845	ABC transporter
DK42_RS05280	COG4603	Belongs to the binding-protein-dependent transport system permease family
DK42_RS05285	COG1079	Belongs to the binding-protein-dependent transport system permease family
DK42_RS05305	COG3764	Sortase (surface protein transpeptidase)
DK42_RS05310	COG0346	lactoylglutathione lyase activity
DK42_RS05315	COG3344	reverse transcriptase
DK42_RS05340	COG2188	Transcriptional regulator
DK42_RS05345	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DK42_RS05355	COG1464	Belongs to the NlpA lipoprotein family
DK42_RS05370	COG1136	(ABC) transporter
DK42_RS05380	COG0745	RESPONSE REGULATOR receiver
DK42_RS05385	COG5002	protein histidine kinase activity
DK42_RS05390	COG4974	Belongs to the 'phage' integrase family
DK42_RS05395	COG4166	transmembrane transport
DK42_RS05410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DK42_RS05415	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DK42_RS05420	COG5002	protein histidine kinase activity
DK42_RS05425	COG0745	RESPONSE REGULATOR receiver
DK42_RS05435	COG0704	Plays a role in the regulation of phosphate uptake
DK42_RS05440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DK42_RS05445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DK42_RS05450	COG0581	inorganic phosphate transmembrane transporter activity
DK42_RS05455	COG0573	inorganic phosphate transmembrane transporter activity
DK42_RS05465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DK42_RS05465	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DK42_RS05470	COG0483	inositol monophosphate 1-phosphatase activity
DK42_RS05475	COG4476	Belongs to the UPF0223 family
DK42_RS05485	COG0196	riboflavin kinase activity
DK42_RS05490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DK42_RS05520	COG1136	(ABC) transporter
DK42_RS05525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DK42_RS05530	COG0758	DNA mediated transformation
DK42_RS05535	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DK42_RS05540	COG4604	ABC transporter, ATP-binding protein
DK42_RS05545	COG4605	iron ion homeostasis
DK42_RS05550	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DK42_RS05555	COG0110	maltose O-acetyltransferase activity
DK42_RS05565	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DK42_RS05570	COG1376	ErfK ybiS ycfS ynhG family protein
DK42_RS05575	COG1966	Carbon starvation protein
DK42_RS05580	COG3279	Response regulator of the LytR AlgR family
DK42_RS05585	COG3275	phosphorelay sensor kinase activity
DK42_RS05710	COG0505	Belongs to the CarA family
DK42_RS05720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DK42_RS05725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DK42_RS05730	COG0284	orotidine-5'-phosphate decarboxylase activity
DK42_RS05740	COG0488	(ABC) transporter
DK42_RS05750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DK42_RS05760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DK42_RS05765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DK42_RS05800	COG0095	Lipoate-protein ligase
DK42_RS05810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DK42_RS05815	COG4684	Psort location CytoplasmicMembrane, score
DK42_RS05820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DK42_RS05830	COG2801	Transposase and inactivated derivatives
DK42_RS05840	COG1132	(ABC) transporter
DK42_RS05860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DK42_RS05870	COG2890	protein-(glutamine-N5) methyltransferase activity
DK42_RS05875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DK42_RS05885	COG1942	4-Oxalocrotonate Tautomerase
DK42_RS05900	COG1053	succinate dehydrogenase
DK42_RS05900	COG0431	NADPH-dependent FMN reductase
DK42_RS05900	COG3976	FMN-binding domain protein
DK42_RS05910	COG2233	PERMEase
DK42_RS05920	COG0516	GMP reductase activity
DK42_RS05925	COG0477	Major facilitator Superfamily
DK42_RS05940	COG4221	oxidoreductase activity
DK42_RS05945	COG0280	phosphate acetyltransferase
DK42_RS05950	COG0564	pseudouridine synthase activity
DK42_RS05955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DK42_RS05960	COG2357	RelA SpoT domain protein
DK42_RS05975	COG1104	cysteine desulfurase activity
DK42_RS05995	COG0628	permease
DK42_RS06010	COG0561	phosphatase activity
DK42_RS06020	COG0038	chloride channel
DK42_RS06030	COG1177	transmembrane transport
DK42_RS06035	COG1176	ABC-type spermidine putrescine transport system, permease component I
DK42_RS06045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DK42_RS06050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DK42_RS06070	COG0285	dihydrofolate synthase activity
DK42_RS06075	COG2962	Rard protein
DK42_RS06100	COG3344	reverse transcriptase
DK42_RS06105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DK42_RS06110	COG1012	belongs to the aldehyde dehydrogenase family
DK42_RS06185	COG2261	transglycosylase associated protein
DK42_RS06210	COG1115	amino acid carrier protein
DK42_RS06215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DK42_RS06225	COG1346	cytolysis
DK42_RS06260	COG4974	Belongs to the 'phage' integrase family
DK42_RS06275	COG0539	negative regulation of cytoplasmic translation
DK42_RS06295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DK42_RS06305	COG0187	DNA topoisomerase II activity
DK42_RS06310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DK42_RS06315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DK42_RS06325	COG1083	cytidylyl-transferase
DK42_RS06325	COG2755	lipolytic protein G-D-S-L family
DK42_RS06340	COG2089	acid synthase
DK42_RS06365	COG1216	Glycosyl transferase, family 2
DK42_RS06365	COG1442	glycosyl transferase family 8
DK42_RS06390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DK42_RS06415	COG1316	TRANSCRIPTIONal
DK42_RS06440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DK42_RS06455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DK42_RS06475	COG3842	ATPase activity
DK42_RS06490	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DK42_RS06495	COG3527	Alpha-acetolactate decarboxylase
DK42_RS06500	COG0028	Belongs to the TPP enzyme family
DK42_RS06505	COG0457	Tetratricopeptide repeat
DK42_RS06510	COG0628	permease
DK42_RS06520	COG1051	belongs to the nudix hydrolase family
DK42_RS06525	COG5492	domain, Protein
DK42_RS06530	COG1088	dTDP-glucose 4,6-dehydratase activity
DK42_RS06540	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DK42_RS06545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DK42_RS06555	COG2384	SAM-dependent methyltransferase
DK42_RS06575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DK42_RS06575	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DK42_RS06580	COG0300	oxidoreductase activity
DK42_RS06595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DK42_RS06630	COG1573	uracil-dna glycosylase
DK42_RS06635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DK42_RS06645	COG0584	glycerophosphoryl diester phosphodiesterase
DK42_RS06650	COG0322	excinuclease ABC activity
DK42_RS06660	COG0534	Mate efflux family protein
DK42_RS06695	COG2801	Transposase and inactivated derivatives
DK42_RS06715	COG0803	Belongs to the bacterial solute-binding protein 9 family
DK42_RS06720	COG5433	transposase activity
DK42_RS06745	COG2176	DNA-directed DNA polymerase activity
DK42_RS06755	COG4974	Belongs to the 'phage' integrase family
DK42_RS06785	COG1674	ftsk spoiiie
DK42_RS06825	COG2040	homocysteine
DK42_RS06865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DK42_RS06875	COG3425	synthase
DK42_RS06890	COG1272	protein, Hemolysin III
DK42_RS06935	COG0745	RESPONSE REGULATOR receiver
DK42_RS06940	COG2357	RelA SpoT domain protein
DK42_RS06945	COG1132	(ABC) transporter
DK42_RS06960	COG0737	Belongs to the 5'-nucleotidase family
DK42_RS06965	COG0242	peptide deformylase activity
DK42_RS06970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DK42_RS06980	COG1132	(ABC) transporter
DK42_RS06995	COG0488	(ABC) transporter
DK42_RS07015	COG5433	transposase activity
DK42_RS07030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DK42_RS07030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DK42_RS07030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DK42_RS07035	COG1105	Belongs to the carbohydrate kinase PfkB family
DK42_RS07040	COG1349	DNA-binding transcription factor activity
DK42_RS07095	COG1837	Belongs to the UPF0109 family
DK42_RS07100	COG0228	four-way junction DNA binding
DK42_RS07105	COG0577	efflux transmembrane transporter activity
DK42_RS07110	COG1136	(ABC) transporter
DK42_RS07115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DK42_RS07125	COG0505	Belongs to the CarA family
DK42_RS07135	COG0564	pseudouridine synthase activity
DK42_RS07145	COG0583	DNA-binding transcription factor activity
DK42_RS07150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DK42_RS07170	COG0301	tRNA thio-modification
DK42_RS07175	COG1104	cysteine desulfurase activity
DK42_RS07185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DK42_RS07190	COG3679	Belongs to the UPF0342 family
DK42_RS07195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DK42_RS07210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DK42_RS07215	COG1368	sulfuric ester hydrolase activity
DK42_RS07220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DK42_RS07230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DK42_RS07235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DK42_RS07260	COG2244	polysaccharide biosynthetic process
DK42_RS07265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DK42_RS07270	COG1120	ATPase activity
DK42_RS07275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DK42_RS07280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DK42_RS07285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DK42_RS07300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DK42_RS07305	COG1253	flavin adenine dinucleotide binding
DK42_RS07310	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DK42_RS07315	COG1242	4 iron, 4 sulfur cluster binding
DK42_RS07320	COG0671	phosphoesterase, PA-phosphatase related
DK42_RS07325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DK42_RS07360	COG0297	glycogen (starch) synthase activity
DK42_RS07400	COG3475	LICD family
DK42_RS07415	COG0463	Glycosyl transferase, family 2
DK42_RS07420	COG1215	transferase activity, transferring glycosyl groups
DK42_RS07430	COG1091	dTDP-4-dehydrorhamnose reductase activity
DK42_RS07435	COG2151	metal-sulfur cluster biosynthetic enzyme
DK42_RS07440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DK42_RS07445	COG0358	DNA primase activity
DK42_RS07450	COG1970	mechanosensitive ion channel activity
DK42_RS07465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DK42_RS07480	COG1054	Belongs to the UPF0176 family
DK42_RS07500	COG0058	SHG alpha-glucan phosphorylase activity
DK42_RS07505	COG1640	4-alpha-glucanotransferase
DK42_RS07510	COG1609	Transcriptional regulator
DK42_RS07520	COG1175	transmembrane transport
DK42_RS07525	COG3833	ABC-type maltose transport systems, permease component
DK42_RS07530	COG3104	oligopeptide transport
DK42_RS07550	COG0438	transferase activity, transferring glycosyl groups
DK42_RS07575	COG0201	protein transport
DK42_RS07580	COG1442	glycosyl transferase family 8
DK42_RS07585	COG1442	glycosyl transferase family 8
DK42_RS07585	COG1216	Glycosyl transferase, family 2
DK42_RS07590	COG1442	glycosyl transferase family 8
DK42_RS07595	COG1216	Glycosyl transferase, family 2
DK42_RS07595	COG1442	glycosyl transferase family 8
DK42_RS07600	COG1442	glycosyl transferase family 8
DK42_RS07630	COG0765	amino acid transport
DK42_RS07635	COG1126	abc transporter atp-binding protein
DK42_RS07660	COG2309	aminopeptidase activity
DK42_RS07670	COG0154	amidase activity
DK42_RS07675	COG1187	pseudouridine synthase activity
DK42_RS07680	COG0656	L-ascorbic acid biosynthetic process
DK42_RS07685	COG0778	Nitroreductase
DK42_RS07690	COG0346	lactoylglutathione lyase activity
DK42_RS07695	COG0463	Glycosyl transferase, family 2
DK42_RS07700	COG1113	amino acid transport
DK42_RS07705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DK42_RS07710	COG0557	exoribonuclease II activity
DK42_RS07720	COG2814	Major facilitator Superfamily
DK42_RS07730	COG1131	(ABC) transporter
DK42_RS07740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DK42_RS07745	COG1396	sequence-specific DNA binding
DK42_RS07785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DK42_RS07790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DK42_RS07810	COG1702	phosphate starvation-inducible protein PhoH
DK42_RS07835	COG0233	cytoplasmic translational termination
DK42_RS07850	COG0444	Belongs to the ABC transporter superfamily
DK42_RS07855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DK42_RS07865	COG0747	negative chemotaxis
DK42_RS07870	COG0081	regulation of translation
DK42_RS07890	COG1473	amidohydrolase
DK42_RS07895	COG0583	DNA-binding transcription factor activity
DK42_RS07905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DK42_RS07910	COG1674	ftsk spoiiie
DK42_RS07915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DK42_RS07940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DK42_RS07975	COG0673	inositol 2-dehydrogenase activity
DK42_RS07990	COG1028	Short-chain dehydrogenase reductase Sdr
DK42_RS08040	COG3344	reverse transcriptase
DK42_RS08045	COG1114	Component of the transport system for branched-chain amino acids
DK42_RS08050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DK42_RS08050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DK42_RS08065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK42_RS08075	COG0708	Exodeoxyribonuclease III
DK42_RS08085	COG1393	Belongs to the ArsC family
DK42_RS08090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DK42_RS08095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DK42_RS08105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DK42_RS08125	COG0470	DNA polymerase III
DK42_RS08135	COG0517	IMP dehydrogenase activity
DK42_RS08175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DK42_RS08180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DK42_RS08190	COG0531	amino acid
DK42_RS08195	COG0569	domain protein
DK42_RS08210	COG1187	pseudouridine synthase activity
DK42_RS08220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DK42_RS08225	COG0582	viral genome integration into host DNA
DK42_RS08245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DK42_RS08260	COG1827	regulation of RNA biosynthetic process
DK42_RS08275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DK42_RS08280	COG1254	Belongs to the acylphosphatase family
DK42_RS08285	COG0706	membrane insertase activity
DK42_RS08290	COG0765	amino acid transport
DK42_RS08295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DK42_RS08310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DK42_RS08320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DK42_RS08340	COG1484	DNA-dependent DNA replication
DK42_RS08355	COG5002	protein histidine kinase activity
DK42_RS08360	COG0745	RESPONSE REGULATOR receiver
DK42_RS08370	COG0501	Belongs to the peptidase M48B family
DK42_RS08375	COG1704	LemA family
DK42_RS08380	COG0357	Ribosomal RNA small subunit methyltransferase G
DK42_RS08385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DK42_RS08390	COG0569	domain protein
DK42_RS08400	COG1122	ATPase activity
DK42_RS08410	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DK42_RS08415	COG1114	Component of the transport system for branched-chain amino acids
DK42_RS08420	COG1063	alcohol dehydrogenase
DK42_RS08450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DK42_RS08455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DK42_RS08460	COG0217	transcriptional regulatory protein
DK42_RS08465	COG2376	Dihydroxyacetone kinase
DK42_RS08470	COG1309	transcriptional regulator
DK42_RS08475	COG2376	Dihydroxyacetone kinase
DK42_RS08480	COG1461	Dihydroxyacetone kinase
DK42_RS08485	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DK42_RS08490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DK42_RS08500	COG0789	Transcriptional regulator
DK42_RS08505	COG1323	Belongs to the UPF0348 family
DK42_RS08515	COG2226	methyltransferase
DK42_RS08520	COG0799	negative regulation of ribosome biogenesis
DK42_RS08530	COG1713	HD superfamily hydrolase involved in NAD metabolism
DK42_RS08535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DK42_RS08540	COG1534	Rna-binding protein
DK42_RS08545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DK42_RS08550	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DK42_RS08560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DK42_RS08565	COG0154	amidase activity
DK42_RS08570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DK42_RS08575	COG0574	Belongs to the PEP-utilizing enzyme family
DK42_RS08575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DK42_RS08580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DK42_RS08585	COG0517	IMP dehydrogenase activity
DK42_RS08595	COG1335	isochorismatase
DK42_RS08600	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DK42_RS08605	COG0436	Aminotransferase
DK42_RS08610	COG0589	response to stress
DK42_RS08615	COG0561	phosphatase activity
DK42_RS08620	COG0252	asparaginase activity
DK42_RS08630	COG4989	oxidoreductase activity
DK42_RS08635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DK42_RS08640	COG3942	CHAP domain
DK42_RS08640	COG1705	Flagellar rod assembly protein muramidase FlgJ
DK42_RS08650	COG0736	holo-[acyl-carrier-protein] synthase activity
DK42_RS08655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DK42_RS08665	COG5433	transposase activity
DK42_RS08670	COG1482	cell wall glycoprotein biosynthetic process
DK42_RS08675	COG1940	carbohydrate kinase activity
DK42_RS08680	COG2190	(PTS) system
DK42_RS08680	COG1263	PTS System
DK42_RS08680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK42_RS08685	COG1621	beta-fructofuranosidase activity
DK42_RS08690	COG1609	Transcriptional regulator
DK42_RS08695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DK42_RS08705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DK42_RS08710	COG1132	(ABC) transporter
DK42_RS08715	COG1132	(ABC) transporter
DK42_RS08745	COG1021	2,3-dihydroxybenzoate-AMP ligase
DK42_RS08755	COG2131	deaminase
DK42_RS08760	COG0006	proline dipeptidase activity
DK42_RS08770	COG2814	Major facilitator Superfamily
DK42_RS08795	COG0629	single-stranded DNA binding
DK42_RS08800	COG0360	Binds together with S18 to 16S ribosomal RNA
DK42_RS08805	COG1194	a g-specific adenine glycosylase
DK42_RS08815	COG3118	belongs to the thioredoxin family
DK42_RS08825	COG1193	negative regulation of DNA recombination
DK42_RS08840	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DK42_RS08845	COG0681	Belongs to the peptidase S26 family
DK42_RS08850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DK42_RS08865	COG3344	reverse transcriptase
DK42_RS08875	COG1882	Formate acetyltransferase
DK42_RS08880	COG3576	pyridoxamine 5-phosphate
DK42_RS08885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DK42_RS08900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DK42_RS08910	COG2814	Major facilitator Superfamily
DK42_RS08915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DK42_RS08920	COG2936	dipeptidyl-peptidase activity
DK42_RS08930	COG0142	geranyltranstransferase activity
DK42_RS08935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DK42_RS08940	COG4988	ABC transporter
DK42_RS08945	COG1294	oxidase, subunit
DK42_RS08950	COG1271	oxidase subunit
DK42_RS08955	COG1252	NADH dehydrogenase
DK42_RS08970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DK42_RS08975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DK42_RS08980	COG0789	Transcriptional regulator
DK42_RS08995	COG2081	HI0933 family
DK42_RS09015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DK42_RS09020	COG0456	acetyltransferase
DK42_RS09025	COG1214	PFAM Peptidase M22, glycoprotease
DK42_RS09040	COG3942	CHAP domain
DK42_RS09045	COG0174	glutamine synthetase
DK42_RS09050	COG0789	Transcriptional regulator
DK42_RS09060	COG0126	phosphoglycerate kinase activity
DK42_RS09065	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DK42_RS09075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DK42_RS09090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DK42_RS09115	COG1162	GTPase activity
DK42_RS09125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DK42_RS09140	COG0084	hydrolase, TatD family'
DK42_RS09165	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DK42_RS09170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DK42_RS09175	COG1696	Membrane protein involved in D-alanine export
DK42_RS09190	COG5002	protein histidine kinase activity
DK42_RS09195	COG0745	RESPONSE REGULATOR receiver
DK42_RS09205	COG3314	Sporulation integral membrane protein YlbJ
DK42_RS09240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DK42_RS09250	COG0791	NLP P60 protein
DK42_RS09250	COG0741	lytic transglycosylase activity
DK42_RS09280	COG2946	Replication initiation factor
DK42_RS09285	COG1674	ftsk spoiiie
DK42_RS09305	COG3448	diguanylate cyclase activity
DK42_RS09305	COG4175	Glycine betaine
DK42_RS09310	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DK42_RS09330	COG1070	Carbohydrate kinase
DK42_RS09340	COG3775	system Galactitol-specific IIC component
DK42_RS09345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DK42_RS09355	COG1609	Transcriptional regulator
DK42_RS09410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DK42_RS09440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DK42_RS09445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DK42_RS09450	COG1428	Deoxynucleoside kinase
DK42_RS09460	COG0542	response to heat
DK42_RS09465	COG4463	regulation of RNA biosynthetic process
DK42_RS09475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DK42_RS09485	COG0450	alkyl hydroperoxide reductase
DK42_RS09515	COG3177	Filamentation induced by cAMP protein fic
DK42_RS09570	COG2946	Replication initiation factor
DK42_RS09580	COG4974	Belongs to the 'phage' integrase family
DK42_RS09590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DK42_RS09610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DK42_RS09615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DK42_RS09625	COG0018	arginyl-trna synthetase
DK42_RS09660	COG2818	Glycosylase
DK42_RS09665	COG1546	Belongs to the CinA family
DK42_RS09665	COG1058	Belongs to the CinA family
DK42_RS09670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DK42_RS09675	COG1393	Belongs to the ArsC family
DK42_RS09685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DK42_RS09705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DK42_RS09705	COG1328	CTP reductase activity
DK42_RS09725	COG0602	queuosine metabolic process
DK42_RS09730	COG3022	response to hydroperoxide
DK42_RS09735	COG2514	catechol 2,3-dioxygenase activity
DK42_RS09740	COG0561	phosphatase activity
DK42_RS09750	COG4120	Belongs to the binding-protein-dependent transport system permease family
DK42_RS09755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DK42_RS09755	COG1116	anion transmembrane transporter activity
DK42_RS09760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DK42_RS09780	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DK42_RS09785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DK42_RS09805	COG0564	pseudouridine synthase activity
DK42_RS09810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DK42_RS09830	COG4667	esterase of the alpha-beta hydrolase superfamily
DK42_RS09835	COG2814	Major facilitator Superfamily
DK42_RS09840	COG5433	transposase activity
DK42_RS09860	COG2205	protein histidine kinase activity
DK42_RS09860	COG2770	Histidine kinase
DK42_RS09865	COG0745	RESPONSE REGULATOR receiver
DK42_RS09875	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DK42_RS09890	COG0646	methionine synthase
DK42_RS09890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DK42_RS09900	COG2801	Transposase and inactivated derivatives
DK42_RS09910	COG0371	Dehydrogenase
DK42_RS09925	COG2897	thiosulfate sulfurtransferase activity
DK42_RS09940	COG1694	Mazg nucleotide pyrophosphohydrolase
DK42_RS09955	COG1396	sequence-specific DNA binding
DK42_RS09965	COG1131	(ABC) transporter
DK42_RS10035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DK42_RS10040	COG0456	acetyltransferase
DK42_RS10075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DK42_RS10090	COG0573	inorganic phosphate transmembrane transporter activity
DK42_RS10095	COG0581	inorganic phosphate transmembrane transporter activity
DK42_RS10100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DK42_RS10110	COG0745	RESPONSE REGULATOR receiver
DK42_RS10115	COG5002	protein histidine kinase activity
DK42_RS10120	COG1263	PTS System
DK42_RS10120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK42_RS10120	COG2190	(PTS) system
DK42_RS10130	COG3279	Response regulator of the LytR AlgR family
DK42_RS10140	COG1131	(ABC) transporter
DK42_RS10165	COG3715	PTS system
DK42_RS10170	COG3716	PTS system mannose fructose sorbose family IID component
DK42_RS10175	COG2972	Histidine kinase
DK42_RS10180	COG2207	Transcriptional regulator
DK42_RS10180	COG4753	response regulator
DK42_RS10200	COG1363	Peptidase, m42
DK42_RS10210	COG0737	Belongs to the 5'-nucleotidase family
DK42_RS10220	COG1490	D-aminoacyl-tRNA deacylase activity
DK42_RS10290	COG3842	ATPase activity
DK42_RS10300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DK42_RS10305	COG4565	transcriptional regulatory protein
DK42_RS10310	COG3290	protein histidine kinase activity
DK42_RS10315	COG3493	citrate carrier protein
DK42_RS10330	COG1862	Preprotein translocase
DK42_RS10335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DK42_RS10340	COG4589	Belongs to the CDS family
DK42_RS10355	COG1705	Flagellar rod assembly protein muramidase FlgJ
DK42_RS10355	COG1388	LysM domain
DK42_RS10360	COG2176	DNA-directed DNA polymerase activity
DK42_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
DK42_RS10410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DK42_RS10415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK42_RS10420	COG3715	PTS system
DK42_RS10425	COG3716	PTS system mannose fructose sorbose family IID component
DK42_RS10435	COG1609	Transcriptional regulator
DK42_RS10460	COG3590	peptidase
DK42_RS10465	COG1619	proteins homologs of microcin C7 resistance protein MccF
DK42_RS10480	COG4974	Belongs to the 'phage' integrase family
DK42_RS10490	COG2946	Replication initiation factor
DK42_RS10520	COG3177	Filamentation induced by cAMP protein fic
DK42_RS10545	COG2801	Transposase and inactivated derivatives
DK42_RS10585	COG4974	Belongs to the 'phage' integrase family
DK42_RS10595	COG0745	RESPONSE REGULATOR receiver
DK42_RS10600	COG5002	protein histidine kinase activity
DK42_RS10605	COG3344	reverse transcriptase
DK42_RS10610	COG1288	antiporter activity
DK42_RS10620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DK42_RS10625	COG3852	Histidine kinase
DK42_RS10630	COG0784	Response regulator, receiver
DK42_RS10635	COG1125	glycine betaine transport
DK42_RS10635	COG0517	IMP dehydrogenase activity
DK42_RS10640	COG1174	glycine betaine transport
DK42_RS10650	COG0392	lysyltransferase activity
DK42_RS10650	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DK42_RS10660	COG3759	membrane
DK42_RS10780	COG0582	viral genome integration into host DNA
DK42_RS10795	COG0305	Participates in initiation and elongation during chromosome replication
DK42_RS10815	COG2095	MarC family integral membrane protein
DK42_RS10820	COG0482	sulfurtransferase activity
DK42_RS10825	COG1760	l-serine dehydratase
DK42_RS10830	COG1760	l-serine dehydratase
DK42_RS10840	COG0741	lytic transglycosylase activity
DK42_RS10865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DK42_RS10870	COG0612	Peptidase, M16
DK42_RS10875	COG0612	Peptidase, M16
DK42_RS10880	COG2501	S4 domain
DK42_RS10895	COG3344	reverse transcriptase
DK42_RS10910	COG0516	GMP reductase activity
DK42_RS10910	COG0517	IMP dehydrogenase activity
DK42_RS10920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DK42_RS10935	COG0454	-acetyltransferase
DK42_RS10950	COG0549	Belongs to the carbamate kinase family
DK42_RS10965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DK42_RS10970	COG0488	(ABC) transporter
DK42_RS10975	COG4485	Bacterial membrane protein, YfhO
DK42_RS10995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DK42_RS11000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DK42_RS11005	COG1475	DNA binding