locus-tag	class	description
GBS_RS00010	COG0592	DNA-directed DNA polymerase activity
GBS_RS00015	COG1597	lipid kinase activity
GBS_RS00030	COG0012	GTP binding
GBS_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GBS_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GBS_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GBS_RS00260	COG0436	Aminotransferase
GBS_RS00275	COG0416	fatty acid biosynthetic process
GBS_RS00280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GBS_RS00285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GBS_RS00290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GBS_RS00300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GBS_RS00305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GBS_RS00315	COG0138	bifunctional purine biosynthesis protein purh
GBS_RS00330	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GBS_RS00340	COG1175	transmembrane transport
GBS_RS00345	COG0395	ABC-type sugar transport system, permease component
GBS_RS00360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GBS_RS00370	COG3458	cephalosporin-C deacetylase activity
GBS_RS00385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GBS_RS00405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GBS_RS00420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GBS_RS00430	COG2755	lipolytic protein G-D-S-L family
GBS_RS00430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GBS_RS00435	COG1454	alcohol dehydrogenase
GBS_RS00435	COG1012	belongs to the aldehyde dehydrogenase family
GBS_RS00440	COG1064	alcohol dehydrogenase
GBS_RS00450	COG0534	Mate efflux family protein
GBS_RS00560	COG0201	protein transport
GBS_RS00565	COG0563	adenylate kinase activity
GBS_RS00575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GBS_RS00585	COG0202	RNA polymerase activity
GBS_RS00710	COG1705	Flagellar rod assembly protein muramidase FlgJ
GBS_RS00715	COG1420	regulation of RNA biosynthetic process
GBS_RS00725	COG0443	Heat shock 70 kDa protein
GBS_RS00730	COG0484	heat shock protein binding
GBS_RS00735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GBS_RS00740	COG0101	tRNA pseudouridine synthase activity
GBS_RS00745	COG0351	phosphomethylpyrimidine kinase
GBS_RS00750	COG4720	Psort location CytoplasmicMembrane, score
GBS_RS00760	COG0668	transmembrane transport
GBS_RS00765	COG0544	peptidyl-prolyl cis-trans isomerase activity
GBS_RS00790	COG0756	dUTP diphosphatase activity
GBS_RS00805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GBS_RS00810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GBS_RS00815	COG1879	ABC-type sugar transport system periplasmic component
GBS_RS00820	COG1172	Belongs to the binding-protein-dependent transport system permease family
GBS_RS00825	COG1129	ABC transporter
GBS_RS00830	COG1869	D-ribose catabolic process
GBS_RS00835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GBS_RS00840	COG1609	Transcriptional regulator
GBS_RS00845	COG0577	efflux transmembrane transporter activity
GBS_RS00850	COG1136	(ABC) transporter
GBS_RS00855	COG0745	RESPONSE REGULATOR receiver
GBS_RS00860	COG2205	protein histidine kinase activity
GBS_RS00865	COG0137	argininosuccinate synthase activity
GBS_RS00870	COG0165	Argininosuccinate lyase
GBS_RS00875	COG0191	fructose-bisphosphate aldolase activity
GBS_RS00895	COG1461	Dihydroxyacetone kinase
GBS_RS00910	COG1126	abc transporter atp-binding protein
GBS_RS00915	COG0765	amino acid transport
GBS_RS00935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GBS_RS00945	COG0719	Fe-S assembly protein
GBS_RS00950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GBS_RS00960	COG0719	Fe-S assembly protein
GBS_RS00965	COG1686	Belongs to the peptidase S11 family
GBS_RS00970	COG1686	Belongs to the peptidase S11 family
GBS_RS00975	COG4166	transmembrane transport
GBS_RS00980	COG0601	transmembrane transport
GBS_RS00985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GBS_RS00990	COG0444	Belongs to the ABC transporter superfamily
GBS_RS00995	COG4608	Belongs to the ABC transporter superfamily
GBS_RS01025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GBS_RS01035	COG1121	(ABC) transporter
GBS_RS01040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GBS_RS01050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GBS_RS01055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GBS_RS01055	COG4499	WXG100 protein secretion system (Wss), protein YukC
GBS_RS01075	COG1459	type II secretion system
GBS_RS01110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GBS_RS01130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GBS_RS01135	COG1363	Peptidase, m42
GBS_RS01150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GBS_RS01155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBS_RS01165	COG0629	single-stranded DNA binding
GBS_RS01170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GBS_RS01190	COG1346	cytolysis
GBS_RS01200	COG0601	transmembrane transport
GBS_RS01205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GBS_RS01210	COG1122	ATPase activity
GBS_RS01220	COG1263	PTS System
GBS_RS01220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GBS_RS01225	COG0366	Alpha amylase catalytic
GBS_RS01230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GBS_RS01245	COG3959	Transketolase, thiamine diphosphate binding domain
GBS_RS01250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GBS_RS01255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GBS_RS01265	COG1185	polyribonucleotide nucleotidyltransferase activity
GBS_RS01275	COG1045	serine acetyltransferase
GBS_RS01285	COG0215	cysteine-tRNA ligase activity
GBS_RS01290	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GBS_RS01310	COG1476	TRANSCRIPTIONal
GBS_RS01320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GBS_RS01330	COG4974	Belongs to the 'phage' integrase family
GBS_RS01440	COG1396	sequence-specific DNA binding
GBS_RS01445	COG2814	Major facilitator Superfamily
GBS_RS01455	COG1732	Glycine betaine
GBS_RS01555	COG0582	viral genome integration into host DNA
GBS_RS01600	COG0519	Catalyzes the synthesis of GMP from XMP
GBS_RS01645	COG1695	Transcriptional regulator
GBS_RS01660	COG1755	Isoprenylcysteine carboxyl methyltransferase
GBS_RS01665	COG0752	glycyl-tRNA synthetase alpha subunit
GBS_RS01675	COG0751	glycine-tRNA ligase activity
GBS_RS01700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GBS_RS01705	COG0446	pyridine nucleotide-disulphide oxidoreductase
GBS_RS01725	COG1131	(ABC) transporter
GBS_RS01735	COG1263	PTS System
GBS_RS01735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GBS_RS01735	COG2190	(PTS) system
GBS_RS01740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GBS_RS01745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GBS_RS01750	COG0275	rRNA processing
GBS_RS01760	COG0768	penicillin binding
GBS_RS01770	COG0513	Belongs to the DEAD box helicase family
GBS_RS01785	COG1126	abc transporter atp-binding protein
GBS_RS01795	COG0492	ferredoxin-NADP+ reductase activity
GBS_RS01800	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GBS_RS01810	COG3579	cysteine-type endopeptidase activity
GBS_RS01815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GBS_RS01835	COG0116	Belongs to the methyltransferase superfamily
GBS_RS01845	COG1854	S-ribosylhomocysteine lyase activity
GBS_RS01850	COG4372	Transposase
GBS_RS01850	COG1418	mRNA catabolic process
GBS_RS01855	COG1131	(ABC) transporter
GBS_RS01865	COG4585	Histidine kinase
GBS_RS01870	COG2197	response regulator
GBS_RS01880	COG0194	GDP metabolic process
GBS_RS01890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GBS_RS01895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GBS_RS01900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GBS_RS01900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GBS_RS01910	COG0515	serine threonine protein kinase
GBS_RS01910	COG2815	serine threonine protein kinase
GBS_RS01920	COG4585	Histidine kinase
GBS_RS01925	COG2197	response regulator
GBS_RS01935	COG1098	S1 RNA binding domain
GBS_RS01940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GBS_RS01945	COG1349	DNA-binding transcription factor activity
GBS_RS01955	COG1447	Phosphotransferase system cellobiose-specific component IIA
GBS_RS01965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GBS_RS01970	COG1882	Formate acetyltransferase
GBS_RS01990	COG1739	Uncharacterized protein family UPF0029
GBS_RS01995	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GBS_RS02000	COG1040	competence protein
GBS_RS02035	COG0527	aspartate kinase activity
GBS_RS02040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GBS_RS02045	COG1024	Enoyl-CoA hydratase
GBS_RS02055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GBS_RS02065	COG2070	2-Nitropropane dioxygenase
GBS_RS02070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GBS_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
GBS_RS02080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GBS_RS02095	COG0439	Biotin carboxylase
GBS_RS02115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GBS_RS02130	COG3716	PTS system mannose fructose sorbose family IID component
GBS_RS02135	COG3715	PTS system
GBS_RS02145	COG0561	phosphatase activity
GBS_RS02160	COG2252	PERMEase
GBS_RS02165	COG0802	atpase or kinase
GBS_RS02175	COG1316	TRANSCRIPTIONal
GBS_RS02185	COG0537	adenosine 5'-monophosphoramidase activity
GBS_RS02200	COG1131	(ABC) transporter
GBS_RS02205	COG4473	ABC transporter
GBS_RS02320	COG0551	DNA topoisomerase type I activity
GBS_RS02320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GBS_RS02325	COG0542	response to heat
GBS_RS02355	COG0629	single-stranded DNA binding
GBS_RS02445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GBS_RS02460	COG0195	Participates in both transcription termination and antitermination
GBS_RS02465	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GBS_RS02475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GBS_RS02480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GBS_RS02505	COG2860	membrane
GBS_RS02515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GBS_RS02515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GBS_RS02520	COG1832	CoA-binding protein
GBS_RS02540	COG5002	protein histidine kinase activity
GBS_RS02560	COG1268	BioY protein
GBS_RS02565	COG1234	tRNA 3'-trailer cleavage
GBS_RS02580	COG0166	Belongs to the GPI family
GBS_RS02585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GBS_RS02590	COG0457	Tetratricopeptide repeat
GBS_RS02590	COG0705	Rhomboid family
GBS_RS02595	COG1744	ABC transporter substrate-binding protein PnrA-like
GBS_RS02600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GBS_RS02605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GBS_RS02610	COG0594	ribonuclease P activity
GBS_RS02615	COG0706	membrane insertase activity
GBS_RS02685	COG2137	regulation of response to DNA damage stimulus
GBS_RS02690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GBS_RS02700	COG2153	protein acetylation
GBS_RS02710	COG1442	glycosyl transferase family 8
GBS_RS02710	COG1216	Glycosyl transferase, family 2
GBS_RS02750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GBS_RS02760	COG0789	Transcriptional regulator
GBS_RS02815	COG1396	sequence-specific DNA binding
GBS_RS02880	COG2226	methyltransferase
GBS_RS02900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GBS_RS02910	COG0525	valine-tRNA ligase activity
GBS_RS02920	COG0673	inositol 2-dehydrogenase activity
GBS_RS02930	COG2315	Protein conserved in bacteria
GBS_RS02935	COG2502	aspartate--ammonia ligase
GBS_RS02945	COG0742	ribosomal rna small subunit methyltransferase
GBS_RS02955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GBS_RS02960	COG3480	Lon protease (S16) C-terminal proteolytic domain
GBS_RS02965	COG0737	Belongs to the 5'-nucleotidase family
GBS_RS02970	COG4470	Protein conserved in bacteria
GBS_RS02975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GBS_RS02985	COG1132	(ABC) transporter
GBS_RS02990	COG1132	(ABC) transporter
GBS_RS02995	COG0512	Glutamine amidotransferase of anthranilate synthase
GBS_RS03000	COG1268	BioY protein
GBS_RS03005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GBS_RS03025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GBS_RS03040	COG1940	carbohydrate kinase activity
GBS_RS03045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GBS_RS03050	COG1217	gtp-binding protein TYPA
GBS_RS03060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GBS_RS03085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GBS_RS03090	COG1799	cell septum assembly
GBS_RS03095	COG0762	integral membrane protein
GBS_RS03100	COG2302	S4 RNA-binding domain
GBS_RS03105	COG3599	regulation of cell shape
GBS_RS03110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GBS_RS03120	COG0494	nUDIX hydrolase
GBS_RS03125	COG0542	response to heat
GBS_RS03130	COG4703	Protein of unknown function (DUF1797)
GBS_RS03135	COG0765	amino acid transport
GBS_RS03140	COG1126	abc transporter atp-binding protein
GBS_RS03145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GBS_RS03155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GBS_RS03160	COG1570	exodeoxyribonuclease VII activity
GBS_RS03165	COG1722	exodeoxyribonuclease VII activity
GBS_RS03175	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GBS_RS03180	COG1438	arginine binding
GBS_RS03185	COG0497	DNA recombination
GBS_RS03190	COG1307	EDD domain protein, DegV family
GBS_RS03195	COG2755	lipolytic protein G-D-S-L family
GBS_RS03240	COG1078	dGTPase activity
GBS_RS03265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GBS_RS03275	COG2884	Cell division ATP-binding protein ftsE
GBS_RS03280	COG2177	Part of the ABC transporter FtsEX involved in
GBS_RS03300	COG1199	ATP-dependent helicase activity
GBS_RS03300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GBS_RS03305	COG0436	Aminotransferase
GBS_RS03310	COG0017	Asparaginyl-tRNA synthetase
GBS_RS03330	COG1660	Displays ATPase and GTPase activities
GBS_RS03355	COG0254	rRNA binding
GBS_RS03360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GBS_RS03365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GBS_RS03370	COG0716	FMN binding
GBS_RS03375	COG1605	Chorismate mutase
GBS_RS03375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GBS_RS03380	COG0038	chloride channel
GBS_RS03385	COG0335	large ribosomal subunit rRNA binding
GBS_RS03420	COG1136	(ABC) transporter
GBS_RS03435	COG5002	protein histidine kinase activity
GBS_RS03450	COG0772	Belongs to the SEDS family
GBS_RS03470	COG0560	Phosphoserine phosphatase
GBS_RS03485	COG0148	phosphopyruvate hydratase activity
GBS_RS03495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GBS_RS03505	COG1316	TRANSCRIPTIONal
GBS_RS03520	COG3700	Belongs to the class B bacterial acid phosphatase family
GBS_RS03615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GBS_RS03620	COG4555	ABC transporter
GBS_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
GBS_RS03650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GBS_RS03655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GBS_RS03675	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GBS_RS03680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GBS_RS03710	COG1136	(ABC) transporter
GBS_RS03725	COG0586	Pfam SNARE associated Golgi protein
GBS_RS03730	COG4619	ABC transporter
GBS_RS03735	COG0390	transport system, permease component
GBS_RS03745	COG0583	DNA-binding transcription factor activity
GBS_RS03755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GBS_RS03760	COG2211	Major facilitator Superfamily
GBS_RS03770	COG3250	beta-galactosidase activity
GBS_RS03775	COG2186	Transcriptional regulator
GBS_RS03780	COG0800	Aldolase
GBS_RS03785	COG1904	glucuronate isomerase
GBS_RS03790	COG1312	Catalyzes the dehydration of D-mannonate
GBS_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
GBS_RS03815	COG1609	Transcriptional regulator
GBS_RS03830	COG0438	transferase activity, transferring glycosyl groups
GBS_RS03835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GBS_RS03855	COG0765	amino acid transport
GBS_RS03860	COG0765	amino acid transport
GBS_RS03865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBS_RS03870	COG1126	abc transporter atp-binding protein
GBS_RS03985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GBS_RS03985	COG0551	DNA topoisomerase type I activity
GBS_RS03990	COG0542	response to heat
GBS_RS04020	COG0629	single-stranded DNA binding
GBS_RS04105	COG0745	RESPONSE REGULATOR receiver
GBS_RS04110	COG5002	protein histidine kinase activity
GBS_RS04115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GBS_RS04120	COG2832	Protein of unknown function (DUF454)
GBS_RS04130	COG1196	nuclear chromosome segregation
GBS_RS04135	COG0561	phosphatase activity
GBS_RS04140	COG0561	phosphatase activity
GBS_RS04145	COG0552	protein localization to endoplasmic reticulum
GBS_RS04150	COG3689	TIGRFAM TIGR03943 family protein
GBS_RS04155	COG0701	Predicted permease
GBS_RS04170	COG2183	response to ionizing radiation
GBS_RS04175	COG3091	SprT-like family
GBS_RS04180	COG1983	PspC domain protein
GBS_RS04215	COG0826	peptidase U32
GBS_RS04220	COG4443	Transcriptional Coactivator p15 (PC4)
GBS_RS04230	COG1914	H( )-stimulated, divalent metal cation uptake system
GBS_RS04245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GBS_RS04245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GBS_RS04270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GBS_RS04295	COG1164	Oligoendopeptidase f
GBS_RS04305	COG0772	Belongs to the SEDS family
GBS_RS04325	COG0768	penicillin binding
GBS_RS04340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GBS_RS04345	COG2223	nitrite transmembrane transporter activity
GBS_RS04370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GBS_RS04375	COG2011	ABC-type metal ion transport system permease component
GBS_RS04380	COG1464	Belongs to the NlpA lipoprotein family
GBS_RS04385	COG0513	Belongs to the DEAD box helicase family
GBS_RS04395	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GBS_RS04400	COG0204	Acyl-transferase
GBS_RS04405	COG1596	polysaccharide export
GBS_RS04405	COG1555	photosystem II stabilization
GBS_RS04410	COG2333	competence protein COMEC
GBS_RS04410	COG0658	competence protein
GBS_RS04415	COG0561	phosphatase activity
GBS_RS04420	COG1609	Transcriptional regulator
GBS_RS04425	COG0657	acetylesterase activity
GBS_RS04430	COG2226	methyltransferase
GBS_RS04440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GBS_RS04445	COG3711	transcriptional antiterminator
GBS_RS04450	COG1263	PTS System
GBS_RS04450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GBS_RS04450	COG2190	(PTS) system
GBS_RS04460	COG3835	regulator
GBS_RS04465	COG1929	Belongs to the glycerate kinase type-1 family
GBS_RS04470	COG2610	gluconate transmembrane transporter activity
GBS_RS04480	COG1846	Transcriptional regulator
GBS_RS04485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GBS_RS04495	COG0363	glucosamine-6-phosphate deaminase activity
GBS_RS04500	COG0435	Glutathione S-transferase
GBS_RS04505	COG1187	pseudouridine synthase activity
GBS_RS04520	COG1164	Oligoendopeptidase f
GBS_RS04525	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GBS_RS04530	COG4122	O-methyltransferase activity
GBS_RS04535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GBS_RS04540	COG4894	glucomannan catabolic process
GBS_RS04545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GBS_RS04555	COG1442	glycosyl transferase family 8
GBS_RS04565	COG1476	TRANSCRIPTIONal
GBS_RS04580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GBS_RS04585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GBS_RS04590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GBS_RS04605	COG1012	belongs to the aldehyde dehydrogenase family
GBS_RS04610	COG0726	polysaccharide deacetylase
GBS_RS04615	COG0513	Belongs to the DEAD box helicase family
GBS_RS04620	COG0572	uridine kinase
GBS_RS04625	COG1956	GAF domain-containing protein
GBS_RS04630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GBS_RS04640	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GBS_RS04640	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GBS_RS04645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GBS_RS04665	COG4721	ABC-type cobalt transport system, permease component
GBS_RS04670	COG1122	ATPase activity
GBS_RS04680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GBS_RS04690	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GBS_RS04695	COG0352	thiamine-phosphate diphosphorylase activity
GBS_RS04700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GBS_RS04710	COG4109	DRTGG domain
GBS_RS04715	COG0024	Methionine aminopeptidase
GBS_RS04725	COG2246	polysaccharide biosynthetic process
GBS_RS04730	COG4708	membrane
GBS_RS04735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GBS_RS04740	COG1597	lipid kinase activity
GBS_RS04745	COG1523	belongs to the glycosyl hydrolase 13 family
GBS_RS04750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GBS_RS04755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GBS_RS04760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GBS_RS04765	COG0297	glycogen (starch) synthase activity
GBS_RS04775	COG0356	it plays a direct role in the translocation of protons across the membrane
GBS_RS04790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GBS_RS04795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GBS_RS04800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GBS_RS04805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GBS_RS04815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GBS_RS04830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GBS_RS04840	COG0072	phenylalanine-tRNA ligase activity
GBS_RS04840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBS_RS04845	COG2321	neutral zinc metallopeptidase
GBS_RS04850	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GBS_RS04855	COG1074	ATP-dependent DNA helicase activity
GBS_RS04865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GBS_RS04870	COG0488	(ABC) transporter
GBS_RS04875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GBS_RS04880	COG0508	dehydrogenase complex catalyzes the overall conversion of
GBS_RS04880	COG0022	dehydrogenase e1 component
GBS_RS04885	COG0508	dehydrogenase complex catalyzes the overall conversion of
GBS_RS04895	COG0095	Lipoate-protein ligase
GBS_RS04900	COG3442	glutamine amidotransferase
GBS_RS04905	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GBS_RS04910	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GBS_RS04935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GBS_RS04945	COG0647	UMP catabolic process
GBS_RS04955	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
GBS_RS04960	COG1518	maintenance of DNA repeat elements
GBS_RS04965	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GBS_RS04980	COG0105	UTP biosynthetic process
GBS_RS04985	COG0481	GTPase activity
GBS_RS04995	COG1418	mRNA catabolic process
GBS_RS05000	COG0456	acetyltransferase
GBS_RS05010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GBS_RS05035	COG1131	(ABC) transporter
GBS_RS05040	COG1725	Transcriptional regulator
GBS_RS05050	COG0205	6-phosphofructokinase activity
GBS_RS05055	COG0469	pyruvate kinase activity
GBS_RS05065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GBS_RS05070	COG2824	Alkylphosphonate utilization operon protein PhnA
GBS_RS05075	COG0765	amino acid transport
GBS_RS05080	COG1126	abc transporter atp-binding protein
GBS_RS05095	COG1072	(Pantothenic acid kinase))
GBS_RS05100	COG2813	Specifically methylates the guanine in position
GBS_RS05110	COG1744	ABC transporter substrate-binding protein PnrA-like
GBS_RS05115	COG3845	ABC transporter
GBS_RS05120	COG4603	Belongs to the binding-protein-dependent transport system permease family
GBS_RS05125	COG1079	Belongs to the binding-protein-dependent transport system permease family
GBS_RS05145	COG3764	Sortase (surface protein transpeptidase)
GBS_RS05150	COG0346	lactoylglutathione lyase activity
GBS_RS05170	COG2188	Transcriptional regulator
GBS_RS05175	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GBS_RS05185	COG1464	Belongs to the NlpA lipoprotein family
GBS_RS05200	COG1136	(ABC) transporter
GBS_RS05210	COG0745	RESPONSE REGULATOR receiver
GBS_RS05215	COG5002	protein histidine kinase activity
GBS_RS05220	COG4974	Belongs to the 'phage' integrase family
GBS_RS05225	COG4166	transmembrane transport
GBS_RS05320	COG0629	single-stranded DNA binding
GBS_RS05350	COG0542	response to heat
GBS_RS05355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GBS_RS05355	COG0551	DNA topoisomerase type I activity
GBS_RS05475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GBS_RS05480	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GBS_RS05485	COG5002	protein histidine kinase activity
GBS_RS05490	COG0745	RESPONSE REGULATOR receiver
GBS_RS05500	COG0704	Plays a role in the regulation of phosphate uptake
GBS_RS05505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GBS_RS05510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GBS_RS05515	COG0581	inorganic phosphate transmembrane transporter activity
GBS_RS05520	COG0573	inorganic phosphate transmembrane transporter activity
GBS_RS05530	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GBS_RS05530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GBS_RS05535	COG0483	inositol monophosphate 1-phosphatase activity
GBS_RS05540	COG4476	Belongs to the UPF0223 family
GBS_RS05550	COG0196	riboflavin kinase activity
GBS_RS05555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GBS_RS05585	COG1136	(ABC) transporter
GBS_RS05590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GBS_RS05595	COG0758	DNA mediated transformation
GBS_RS05600	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GBS_RS05605	COG4604	ABC transporter, ATP-binding protein
GBS_RS05610	COG4605	iron ion homeostasis
GBS_RS05615	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GBS_RS05620	COG0110	maltose O-acetyltransferase activity
GBS_RS05630	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GBS_RS05635	COG1376	ErfK ybiS ycfS ynhG family protein
GBS_RS05640	COG1966	Carbon starvation protein
GBS_RS05645	COG3279	Response regulator of the LytR AlgR family
GBS_RS05650	COG3275	phosphorelay sensor kinase activity
GBS_RS05770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GBS_RS05775	COG0505	Belongs to the CarA family
GBS_RS05785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GBS_RS05790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GBS_RS05795	COG0284	orotidine-5'-phosphate decarboxylase activity
GBS_RS05805	COG0488	(ABC) transporter
GBS_RS05815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GBS_RS05825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GBS_RS05830	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GBS_RS05865	COG0095	Lipoate-protein ligase
GBS_RS05875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GBS_RS05880	COG4684	Psort location CytoplasmicMembrane, score
GBS_RS05885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GBS_RS05895	COG1132	(ABC) transporter
GBS_RS05915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GBS_RS05925	COG2890	protein-(glutamine-N5) methyltransferase activity
GBS_RS05930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GBS_RS05940	COG1942	4-Oxalocrotonate Tautomerase
GBS_RS05955	COG1053	succinate dehydrogenase
GBS_RS05955	COG0431	NADPH-dependent FMN reductase
GBS_RS05955	COG3976	FMN-binding domain protein
GBS_RS05965	COG2233	PERMEase
GBS_RS05990	COG3843	relaxase mobilization nuclease domain protein
GBS_RS06045	COG3942	CHAP domain
GBS_RS06045	COG1388	LysM domain
GBS_RS06115	COG3620	sequence-specific DNA binding
GBS_RS06145	COG0516	GMP reductase activity
GBS_RS06150	COG0477	Major facilitator Superfamily
GBS_RS06160	COG3158	transport of potassium into the cell
GBS_RS06165	COG4221	oxidoreductase activity
GBS_RS06170	COG0280	phosphate acetyltransferase
GBS_RS06175	COG0564	pseudouridine synthase activity
GBS_RS06180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GBS_RS06185	COG2357	RelA SpoT domain protein
GBS_RS06200	COG1104	cysteine desulfurase activity
GBS_RS06210	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GBS_RS06215	COG2003	Belongs to the UPF0758 family
GBS_RS06220	COG0628	permease
GBS_RS06225	COG2723	6-phospho-beta-galactosidase activity
GBS_RS06235	COG0561	phosphatase activity
GBS_RS06245	COG0038	chloride channel
GBS_RS06255	COG1177	transmembrane transport
GBS_RS06260	COG1176	ABC-type spermidine putrescine transport system, permease component I
GBS_RS06270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GBS_RS06275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GBS_RS06290	COG0302	gtp cyclohydrolase
GBS_RS06295	COG0285	dihydrofolate synthase activity
GBS_RS06300	COG2962	Rard protein
GBS_RS06325	COG1012	belongs to the aldehyde dehydrogenase family
GBS_RS06355	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GBS_RS06400	COG2261	transglycosylase associated protein
GBS_RS06425	COG1115	amino acid carrier protein
GBS_RS06430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GBS_RS06440	COG1346	cytolysis
GBS_RS06475	COG4974	Belongs to the 'phage' integrase family
GBS_RS06485	COG0539	negative regulation of cytoplasmic translation
GBS_RS06505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GBS_RS06515	COG0187	DNA topoisomerase II activity
GBS_RS06520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GBS_RS06525	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GBS_RS06535	COG1083	cytidylyl-transferase
GBS_RS06535	COG2755	lipolytic protein G-D-S-L family
GBS_RS06550	COG2089	acid synthase
GBS_RS06565	COG1442	glycosyl transferase family 8
GBS_RS06565	COG1216	Glycosyl transferase, family 2
GBS_RS06570	COG1216	Glycosyl transferase, family 2
GBS_RS06570	COG1442	glycosyl transferase family 8
GBS_RS06585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GBS_RS06590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GBS_RS06595	COG0489	protein tyrosine kinase activity
GBS_RS06600	COG3944	biosynthesis protein
GBS_RS06605	COG4464	protein tyrosine phosphatase activity
GBS_RS06610	COG1316	TRANSCRIPTIONal
GBS_RS06635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GBS_RS06650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GBS_RS06670	COG3842	ATPase activity
GBS_RS06685	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GBS_RS06690	COG3527	Alpha-acetolactate decarboxylase
GBS_RS06695	COG0028	Belongs to the TPP enzyme family
GBS_RS06700	COG0457	Tetratricopeptide repeat
GBS_RS06705	COG0628	permease
GBS_RS06715	COG1051	belongs to the nudix hydrolase family
GBS_RS06720	COG5492	domain, Protein
GBS_RS06725	COG1088	dTDP-glucose 4,6-dehydratase activity
GBS_RS06735	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GBS_RS06740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBS_RS06750	COG2384	SAM-dependent methyltransferase
GBS_RS06770	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GBS_RS06770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GBS_RS06775	COG0300	oxidoreductase activity
GBS_RS06790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GBS_RS06795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GBS_RS06820	COG1573	uracil-dna glycosylase
GBS_RS06825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GBS_RS06835	COG0584	glycerophosphoryl diester phosphodiesterase
GBS_RS06840	COG0322	excinuclease ABC activity
GBS_RS06850	COG0534	Mate efflux family protein
GBS_RS06885	COG2801	Transposase and inactivated derivatives
GBS_RS06905	COG0803	Belongs to the bacterial solute-binding protein 9 family
GBS_RS06930	COG2176	DNA-directed DNA polymerase activity
GBS_RS06940	COG4974	Belongs to the 'phage' integrase family
GBS_RS06970	COG1674	ftsk spoiiie
GBS_RS06995	COG4974	Belongs to the 'phage' integrase family
GBS_RS07005	COG1396	sequence-specific DNA binding
GBS_RS07015	COG2723	6-phospho-beta-galactosidase activity
GBS_RS07030	COG3711	transcriptional antiterminator
GBS_RS07035	COG3684	Belongs to the aldolase LacD family
GBS_RS07040	COG1105	Belongs to the carbohydrate kinase PfkB family
GBS_RS07045	COG0698	ribose 5-phosphate isomerase
GBS_RS07050	COG0698	ribose 5-phosphate isomerase
GBS_RS07055	COG1349	DNA-binding transcription factor activity
GBS_RS07060	COG3843	relaxase mobilization nuclease domain protein
GBS_RS07085	COG0542	response to heat
GBS_RS07090	COG1396	sequence-specific DNA binding
GBS_RS07220	COG0270	DNA (cytosine-5-)-methyltransferase activity
GBS_RS07245	COG2040	homocysteine
GBS_RS07250	COG0833	amino acid
GBS_RS07270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GBS_RS07285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GBS_RS07295	COG3425	synthase
GBS_RS07310	COG1272	protein, Hemolysin III
GBS_RS07355	COG0745	RESPONSE REGULATOR receiver
GBS_RS07360	COG2357	RelA SpoT domain protein
GBS_RS07365	COG1132	(ABC) transporter
GBS_RS07380	COG0737	Belongs to the 5'-nucleotidase family
GBS_RS07385	COG0242	peptide deformylase activity
GBS_RS07390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GBS_RS07400	COG1132	(ABC) transporter
GBS_RS07415	COG0488	(ABC) transporter
GBS_RS07445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GBS_RS07445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GBS_RS07445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GBS_RS07450	COG1105	Belongs to the carbohydrate kinase PfkB family
GBS_RS07455	COG1349	DNA-binding transcription factor activity
GBS_RS07460	COG1388	LysM domain
GBS_RS07460	COG1705	Flagellar rod assembly protein muramidase FlgJ
GBS_RS07510	COG1837	Belongs to the UPF0109 family
GBS_RS07515	COG0228	four-way junction DNA binding
GBS_RS07520	COG0577	efflux transmembrane transporter activity
GBS_RS07525	COG1136	(ABC) transporter
GBS_RS07530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBS_RS07540	COG0505	Belongs to the CarA family
GBS_RS07550	COG0564	pseudouridine synthase activity
GBS_RS07560	COG0583	DNA-binding transcription factor activity
GBS_RS07565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GBS_RS07585	COG0301	tRNA thio-modification
GBS_RS07590	COG1104	cysteine desulfurase activity
GBS_RS07600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GBS_RS07605	COG3679	Belongs to the UPF0342 family
GBS_RS07610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GBS_RS07615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GBS_RS07625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GBS_RS07630	COG1368	sulfuric ester hydrolase activity
GBS_RS07635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GBS_RS07645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GBS_RS07650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GBS_RS07670	COG2195	Cleaves the N-terminal amino acid of tripeptides
GBS_RS07675	COG2244	polysaccharide biosynthetic process
GBS_RS07680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GBS_RS07685	COG1120	ATPase activity
GBS_RS07690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GBS_RS07695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GBS_RS07700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GBS_RS07710	COG1227	inorganic diphosphatase activity
GBS_RS07715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GBS_RS07720	COG1253	flavin adenine dinucleotide binding
GBS_RS07725	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GBS_RS07730	COG1242	4 iron, 4 sulfur cluster binding
GBS_RS07735	COG0671	phosphoesterase, PA-phosphatase related
GBS_RS07740	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GBS_RS07775	COG0297	glycogen (starch) synthase activity
GBS_RS07810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GBS_RS07815	COG3475	LICD family
GBS_RS07830	COG0463	Glycosyl transferase, family 2
GBS_RS07835	COG1215	transferase activity, transferring glycosyl groups
GBS_RS07845	COG1091	dTDP-4-dehydrorhamnose reductase activity
GBS_RS07850	COG2151	metal-sulfur cluster biosynthetic enzyme
GBS_RS07855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GBS_RS07860	COG0358	DNA primase activity
GBS_RS07865	COG1970	mechanosensitive ion channel activity
GBS_RS07880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBS_RS07885	COG0004	ammonium transporteR
GBS_RS07895	COG1054	Belongs to the UPF0176 family
GBS_RS07905	COG2271	Major facilitator Superfamily
GBS_RS07910	COG0058	SHG alpha-glucan phosphorylase activity
GBS_RS07915	COG1640	4-alpha-glucanotransferase
GBS_RS07920	COG1609	Transcriptional regulator
GBS_RS07930	COG1175	transmembrane transport
GBS_RS07935	COG3833	ABC-type maltose transport systems, permease component
GBS_RS07940	COG3104	oligopeptide transport
GBS_RS07960	COG0438	transferase activity, transferring glycosyl groups
GBS_RS07965	COG0653	protein targeting
GBS_RS07985	COG0201	protein transport
GBS_RS07990	COG1442	glycosyl transferase family 8
GBS_RS07995	COG1442	glycosyl transferase family 8
GBS_RS07995	COG1216	Glycosyl transferase, family 2
GBS_RS08000	COG1442	glycosyl transferase family 8
GBS_RS08005	COG1216	Glycosyl transferase, family 2
GBS_RS08005	COG1442	glycosyl transferase family 8
GBS_RS08010	COG1442	glycosyl transferase family 8
GBS_RS08045	COG0765	amino acid transport
GBS_RS08050	COG1126	abc transporter atp-binding protein
GBS_RS08075	COG2309	aminopeptidase activity
GBS_RS08085	COG0154	amidase activity
GBS_RS08090	COG1187	pseudouridine synthase activity
GBS_RS08095	COG0656	L-ascorbic acid biosynthetic process
GBS_RS08100	COG0778	Nitroreductase
GBS_RS08105	COG0346	lactoylglutathione lyase activity
GBS_RS08110	COG0463	Glycosyl transferase, family 2
GBS_RS08115	COG1113	amino acid transport
GBS_RS08120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GBS_RS08125	COG0557	exoribonuclease II activity
GBS_RS08135	COG2814	Major facilitator Superfamily
GBS_RS08145	COG1131	(ABC) transporter
GBS_RS08150	COG0237	dephospho-CoA kinase activity
GBS_RS08155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GBS_RS08160	COG1396	sequence-specific DNA binding
GBS_RS08200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GBS_RS08205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GBS_RS08225	COG1702	phosphate starvation-inducible protein PhoH
GBS_RS08240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GBS_RS08250	COG0233	cytoplasmic translational termination
GBS_RS08255	COG0528	UMP kinase activity
GBS_RS08265	COG0444	Belongs to the ABC transporter superfamily
GBS_RS08270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GBS_RS08275	COG0601	transmembrane transport
GBS_RS08280	COG0747	negative chemotaxis
GBS_RS08285	COG0081	regulation of translation
GBS_RS08290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GBS_RS08300	COG1473	amidohydrolase
GBS_RS08305	COG0583	DNA-binding transcription factor activity
GBS_RS08315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GBS_RS08320	COG1674	ftsk spoiiie
GBS_RS08325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GBS_RS08350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GBS_RS08365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GBS_RS08380	COG0673	inositol 2-dehydrogenase activity
GBS_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
GBS_RS08445	COG1114	Component of the transport system for branched-chain amino acids
GBS_RS08450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBS_RS08450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBS_RS08465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GBS_RS08475	COG0708	Exodeoxyribonuclease III
GBS_RS08480	COG1393	Belongs to the ArsC family
GBS_RS08485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GBS_RS08490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GBS_RS08500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GBS_RS08520	COG0470	DNA polymerase III
GBS_RS08530	COG0517	IMP dehydrogenase activity
GBS_RS08570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GBS_RS08575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GBS_RS08585	COG0531	amino acid
GBS_RS08590	COG0569	domain protein
GBS_RS08600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GBS_RS08605	COG1187	pseudouridine synthase activity
GBS_RS08615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GBS_RS08620	COG0582	viral genome integration into host DNA
GBS_RS08640	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GBS_RS08655	COG1827	regulation of RNA biosynthetic process
GBS_RS08670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GBS_RS08675	COG1254	Belongs to the acylphosphatase family
GBS_RS08680	COG0706	membrane insertase activity
GBS_RS08685	COG0765	amino acid transport
GBS_RS08690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBS_RS08705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GBS_RS08715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GBS_RS08730	COG1160	GTP binding
GBS_RS08735	COG1484	DNA-dependent DNA replication
GBS_RS08750	COG5002	protein histidine kinase activity
GBS_RS08755	COG0745	RESPONSE REGULATOR receiver
GBS_RS08765	COG0501	Belongs to the peptidase M48B family
GBS_RS08770	COG1704	LemA family
GBS_RS08775	COG0357	Ribosomal RNA small subunit methyltransferase G
GBS_RS08780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GBS_RS08785	COG0569	domain protein
GBS_RS08795	COG1122	ATPase activity
GBS_RS08805	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GBS_RS08810	COG1114	Component of the transport system for branched-chain amino acids
GBS_RS08815	COG1063	alcohol dehydrogenase
GBS_RS08825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GBS_RS08840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBS_RS08845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GBS_RS08850	COG0217	transcriptional regulatory protein
GBS_RS08855	COG2376	Dihydroxyacetone kinase
GBS_RS08860	COG1309	transcriptional regulator
GBS_RS08865	COG2376	Dihydroxyacetone kinase
GBS_RS08870	COG1461	Dihydroxyacetone kinase
GBS_RS08875	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GBS_RS08880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GBS_RS08890	COG0789	Transcriptional regulator
GBS_RS08895	COG1323	Belongs to the UPF0348 family
GBS_RS08905	COG2226	methyltransferase
GBS_RS08910	COG0799	negative regulation of ribosome biogenesis
GBS_RS08920	COG1713	HD superfamily hydrolase involved in NAD metabolism
GBS_RS08925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GBS_RS08930	COG1534	Rna-binding protein
GBS_RS08935	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GBS_RS08940	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GBS_RS08950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GBS_RS08955	COG0154	amidase activity
GBS_RS08960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GBS_RS08965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GBS_RS08965	COG0574	Belongs to the PEP-utilizing enzyme family
GBS_RS08970	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GBS_RS08975	COG0517	IMP dehydrogenase activity
GBS_RS08985	COG1335	isochorismatase
GBS_RS08990	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GBS_RS08995	COG0436	Aminotransferase
GBS_RS09000	COG0589	response to stress
GBS_RS09005	COG0561	phosphatase activity
GBS_RS09010	COG0252	asparaginase activity
GBS_RS09020	COG4989	oxidoreductase activity
GBS_RS09025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GBS_RS09030	COG1705	Flagellar rod assembly protein muramidase FlgJ
GBS_RS09030	COG3942	CHAP domain
GBS_RS09040	COG0736	holo-[acyl-carrier-protein] synthase activity
GBS_RS09045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GBS_RS09055	COG1482	cell wall glycoprotein biosynthetic process
GBS_RS09060	COG1940	carbohydrate kinase activity
GBS_RS09065	COG2190	(PTS) system
GBS_RS09065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GBS_RS09065	COG1263	PTS System
GBS_RS09070	COG1621	beta-fructofuranosidase activity
GBS_RS09075	COG1609	Transcriptional regulator
GBS_RS09080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GBS_RS09090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GBS_RS09095	COG1132	(ABC) transporter
GBS_RS09105	COG1129	ABC transporter
GBS_RS09130	COG1021	2,3-dihydroxybenzoate-AMP ligase
GBS_RS09140	COG2131	deaminase
GBS_RS09145	COG0006	proline dipeptidase activity
GBS_RS09155	COG2814	Major facilitator Superfamily
GBS_RS09180	COG0629	single-stranded DNA binding
GBS_RS09185	COG0360	Binds together with S18 to 16S ribosomal RNA
GBS_RS09190	COG1194	a g-specific adenine glycosylase
GBS_RS09200	COG3118	belongs to the thioredoxin family
GBS_RS09210	COG1193	negative regulation of DNA recombination
GBS_RS09225	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GBS_RS09230	COG0681	Belongs to the peptidase S26 family
GBS_RS09235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GBS_RS09250	COG1882	Formate acetyltransferase
GBS_RS09255	COG3576	pyridoxamine 5-phosphate
GBS_RS09260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GBS_RS09275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GBS_RS09285	COG2814	Major facilitator Superfamily
GBS_RS09290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GBS_RS09295	COG2936	dipeptidyl-peptidase activity
GBS_RS09305	COG0142	geranyltranstransferase activity
GBS_RS09310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GBS_RS09315	COG4988	ABC transporter
GBS_RS09320	COG1294	oxidase, subunit
GBS_RS09325	COG1271	oxidase subunit
GBS_RS09330	COG1252	NADH dehydrogenase
GBS_RS09345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GBS_RS09350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GBS_RS09355	COG0789	Transcriptional regulator
GBS_RS09370	COG2081	HI0933 family
GBS_RS09390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GBS_RS09395	COG0456	acetyltransferase
GBS_RS09400	COG1214	PFAM Peptidase M22, glycoprotease
GBS_RS09415	COG3942	CHAP domain
GBS_RS09420	COG0174	glutamine synthetase
GBS_RS09425	COG0789	Transcriptional regulator
GBS_RS09435	COG0126	phosphoglycerate kinase activity
GBS_RS09440	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GBS_RS09450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GBS_RS09465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GBS_RS09490	COG1162	GTPase activity
GBS_RS09500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GBS_RS09515	COG0084	hydrolase, TatD family'
GBS_RS09540	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GBS_RS09545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GBS_RS09550	COG1696	Membrane protein involved in D-alanine export
GBS_RS09555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GBS_RS09565	COG5002	protein histidine kinase activity
GBS_RS09570	COG0745	RESPONSE REGULATOR receiver
GBS_RS09580	COG3314	Sporulation integral membrane protein YlbJ
GBS_RS09590	COG4175	Glycine betaine
GBS_RS09590	COG3448	diguanylate cyclase activity
GBS_RS09595	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GBS_RS09615	COG1070	Carbohydrate kinase
GBS_RS09625	COG3775	system Galactitol-specific IIC component
GBS_RS09630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GBS_RS09640	COG1609	Transcriptional regulator
GBS_RS09690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GBS_RS09720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GBS_RS09725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GBS_RS09730	COG1428	Deoxynucleoside kinase
GBS_RS09740	COG0542	response to heat
GBS_RS09745	COG4463	regulation of RNA biosynthetic process
GBS_RS09755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GBS_RS09765	COG0450	alkyl hydroperoxide reductase
GBS_RS09780	COG0025	NhaP-type Na H and K H
GBS_RS09790	COG1619	proteins homologs of microcin C7 resistance protein MccF
GBS_RS09795	COG3590	peptidase
GBS_RS09820	COG1609	Transcriptional regulator
GBS_RS09830	COG3716	PTS system mannose fructose sorbose family IID component
GBS_RS09835	COG3715	PTS system
GBS_RS09840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GBS_RS09845	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GBS_RS09855	COG1028	Short-chain dehydrogenase reductase Sdr
GBS_RS09890	COG2176	DNA-directed DNA polymerase activity
GBS_RS09895	COG1388	LysM domain
GBS_RS09895	COG1705	Flagellar rod assembly protein muramidase FlgJ
GBS_RS09900	COG0442	prolyl-tRNA aminoacylation
GBS_RS09910	COG4589	Belongs to the CDS family
GBS_RS09915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GBS_RS09920	COG1862	Preprotein translocase
GBS_RS09935	COG3493	citrate carrier protein
GBS_RS09940	COG3290	protein histidine kinase activity
GBS_RS09945	COG4565	transcriptional regulatory protein
GBS_RS09950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GBS_RS09960	COG3842	ATPase activity
GBS_RS10035	COG1490	D-aminoacyl-tRNA deacylase activity
GBS_RS10045	COG0737	Belongs to the 5'-nucleotidase family
GBS_RS10055	COG1363	Peptidase, m42
GBS_RS10075	COG4753	response regulator
GBS_RS10075	COG2207	Transcriptional regulator
GBS_RS10080	COG2972	Histidine kinase
GBS_RS10085	COG3716	PTS system mannose fructose sorbose family IID component
GBS_RS10090	COG3715	PTS system
GBS_RS10115	COG1131	(ABC) transporter
GBS_RS10125	COG3279	Response regulator of the LytR AlgR family
GBS_RS10135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GBS_RS10135	COG1263	PTS System
GBS_RS10135	COG2190	(PTS) system
GBS_RS10140	COG5002	protein histidine kinase activity
GBS_RS10145	COG0745	RESPONSE REGULATOR receiver
GBS_RS10155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GBS_RS10160	COG0581	inorganic phosphate transmembrane transporter activity
GBS_RS10165	COG0573	inorganic phosphate transmembrane transporter activity
GBS_RS10180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GBS_RS10195	COG0789	Transcriptional regulator
GBS_RS10215	COG0456	acetyltransferase
GBS_RS10220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GBS_RS10270	COG2378	regulation of single-species biofilm formation
GBS_RS10320	COG1131	(ABC) transporter
GBS_RS10355	COG1131	(ABC) transporter
GBS_RS10365	COG1396	sequence-specific DNA binding
GBS_RS10375	COG1694	Mazg nucleotide pyrophosphohydrolase
GBS_RS10405	COG0371	Dehydrogenase
GBS_RS10415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GBS_RS10415	COG0646	methionine synthase
GBS_RS10420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GBS_RS10430	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GBS_RS10440	COG0745	RESPONSE REGULATOR receiver
GBS_RS10445	COG2205	protein histidine kinase activity
GBS_RS10445	COG2770	Histidine kinase
GBS_RS10455	COG0495	leucyl-tRNA aminoacylation
GBS_RS10460	COG2814	Major facilitator Superfamily
GBS_RS10465	COG4667	esterase of the alpha-beta hydrolase superfamily
GBS_RS10470	COG1442	glycosyl transferase family 8
GBS_RS10475	COG1442	glycosyl transferase family 8
GBS_RS10495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GBS_RS10500	COG0564	pseudouridine synthase activity
GBS_RS10520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GBS_RS10525	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GBS_RS10540	COG0459	protein refolding
GBS_RS10545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GBS_RS10550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GBS_RS10550	COG1116	anion transmembrane transporter activity
GBS_RS10555	COG4120	Belongs to the binding-protein-dependent transport system permease family
GBS_RS10565	COG0561	phosphatase activity
GBS_RS10570	COG2514	catechol 2,3-dioxygenase activity
GBS_RS10575	COG3022	response to hydroperoxide
GBS_RS10580	COG0602	queuosine metabolic process
GBS_RS10600	COG1328	CTP reductase activity
GBS_RS10620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GBS_RS10630	COG1393	Belongs to the ArsC family
GBS_RS10635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GBS_RS10640	COG1546	Belongs to the CinA family
GBS_RS10640	COG1058	Belongs to the CinA family
GBS_RS10645	COG2818	Glycosylase
GBS_RS10660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GBS_RS10680	COG0018	arginyl-trna synthetase
GBS_RS10690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GBS_RS10695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GBS_RS10700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GBS_RS10705	COG0124	histidyl-tRNA synthetase
GBS_RS10715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GBS_RS10765	COG4974	Belongs to the 'phage' integrase family
GBS_RS10800	COG0745	RESPONSE REGULATOR receiver
GBS_RS10805	COG5002	protein histidine kinase activity
GBS_RS10810	COG1288	antiporter activity
GBS_RS10820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GBS_RS10825	COG3852	Histidine kinase
GBS_RS10830	COG0784	Response regulator, receiver
GBS_RS10835	COG0517	IMP dehydrogenase activity
GBS_RS10835	COG1125	glycine betaine transport
GBS_RS10840	COG1174	glycine betaine transport
GBS_RS10845	COG0392	lysyltransferase activity
GBS_RS10845	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GBS_RS10855	COG3759	membrane
GBS_RS10885	COG0305	Participates in initiation and elongation during chromosome replication
GBS_RS10900	COG0445	tRNA wobble uridine modification
GBS_RS10905	COG2095	MarC family integral membrane protein
GBS_RS10910	COG0482	sulfurtransferase activity
GBS_RS10915	COG1760	l-serine dehydratase
GBS_RS10920	COG1760	l-serine dehydratase
GBS_RS10925	COG0741	lytic transglycosylase activity
GBS_RS10950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GBS_RS10955	COG0612	Peptidase, M16
GBS_RS10960	COG0612	Peptidase, M16
GBS_RS10965	COG2501	S4 domain
GBS_RS10985	COG0517	IMP dehydrogenase activity
GBS_RS10985	COG0516	GMP reductase activity
GBS_RS10995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GBS_RS11010	COG0454	-acetyltransferase
GBS_RS11015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GBS_RS11040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GBS_RS11045	COG0488	(ABC) transporter
GBS_RS11050	COG4485	Bacterial membrane protein, YfhO
GBS_RS11070	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GBS_RS11075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GBS_RS11080	COG1475	DNA binding
GBS_RS11090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB