locus-tag	class	description
C2E56_RS00010	COG0592	DNA-directed DNA polymerase activity
C2E56_RS00015	COG1597	lipid kinase activity
C2E56_RS00030	COG0012	GTP binding
C2E56_RS00035	COG0193	aminoacyl-tRNA hydrolase activity
C2E56_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2E56_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2E56_RS00065	COG0037	tRNA processing
C2E56_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2E56_RS00255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2E56_RS00260	COG0436	Aminotransferase
C2E56_RS00275	COG0416	fatty acid biosynthetic process
C2E56_RS00280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2E56_RS00285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2E56_RS00290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2E56_RS00305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2E56_RS00310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2E56_RS00345	COG1175	transmembrane transport
C2E56_RS00350	COG0395	ABC-type sugar transport system, permease component
C2E56_RS00365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2E56_RS00375	COG3458	cephalosporin-C deacetylase activity
C2E56_RS00390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2E56_RS00410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2E56_RS00425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2E56_RS00435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2E56_RS00435	COG2755	lipolytic protein G-D-S-L family
C2E56_RS00440	COG1454	alcohol dehydrogenase
C2E56_RS00440	COG1012	belongs to the aldehyde dehydrogenase family
C2E56_RS00445	COG1064	alcohol dehydrogenase
C2E56_RS00455	COG0534	Mate efflux family protein
C2E56_RS00565	COG0201	protein transport
C2E56_RS00570	COG0563	adenylate kinase activity
C2E56_RS00580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2E56_RS00595	COG0202	RNA polymerase activity
C2E56_RS00730	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E56_RS00740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2E56_RS00755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2E56_RS00765	COG0351	phosphomethylpyrimidine kinase
C2E56_RS00770	COG4720	Psort location CytoplasmicMembrane, score
C2E56_RS00775	COG4475	Protein of unknown function (DUF436)
C2E56_RS00780	COG0668	transmembrane transport
C2E56_RS00810	COG0756	dUTP diphosphatase activity
C2E56_RS00825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2E56_RS00830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2E56_RS00835	COG1879	ABC-type sugar transport system periplasmic component
C2E56_RS00840	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2E56_RS00855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2E56_RS00860	COG1609	Transcriptional regulator
C2E56_RS00865	COG0577	efflux transmembrane transporter activity
C2E56_RS00870	COG1136	(ABC) transporter
C2E56_RS00875	COG0745	RESPONSE REGULATOR receiver
C2E56_RS00880	COG5002	protein histidine kinase activity
C2E56_RS00890	COG0165	Argininosuccinate lyase
C2E56_RS00895	COG0191	fructose-bisphosphate aldolase activity
C2E56_RS00915	COG1461	Dihydroxyacetone kinase
C2E56_RS00930	COG1126	abc transporter atp-binding protein
C2E56_RS00935	COG0765	amino acid transport
C2E56_RS00950	COG4862	establishment of competence for transformation
C2E56_RS00955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2E56_RS00965	COG0719	Fe-S assembly protein
C2E56_RS00970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2E56_RS00980	COG0719	Fe-S assembly protein
C2E56_RS00985	COG1686	Belongs to the peptidase S11 family
C2E56_RS00990	COG1686	Belongs to the peptidase S11 family
C2E56_RS00995	COG4166	transmembrane transport
C2E56_RS01000	COG0601	transmembrane transport
C2E56_RS01005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2E56_RS01010	COG0444	Belongs to the ABC transporter superfamily
C2E56_RS01015	COG4608	Belongs to the ABC transporter superfamily
C2E56_RS01055	COG1121	(ABC) transporter
C2E56_RS01060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2E56_RS01070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2E56_RS01075	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2E56_RS01075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2E56_RS01095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2E56_RS01100	COG1459	type II secretion system
C2E56_RS01155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2E56_RS01160	COG1363	Peptidase, m42
C2E56_RS01175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2E56_RS01180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E56_RS01195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2E56_RS01200	COG3275	phosphorelay sensor kinase activity
C2E56_RS01205	COG3279	Response regulator of the LytR AlgR family
C2E56_RS01215	COG1346	cytolysis
C2E56_RS01225	COG0601	transmembrane transport
C2E56_RS01235	COG1122	ATPase activity
C2E56_RS01245	COG1263	PTS System
C2E56_RS01245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E56_RS01250	COG0366	Alpha amylase catalytic
C2E56_RS01255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E56_RS01270	COG3959	Transketolase, thiamine diphosphate binding domain
C2E56_RS01275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2E56_RS01280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2E56_RS01300	COG1045	serine acetyltransferase
C2E56_RS01310	COG0215	cysteine-tRNA ligase activity
C2E56_RS01315	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C2E56_RS01335	COG1476	TRANSCRIPTIONal
C2E56_RS01340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2E56_RS01360	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E56_RS01360	COG3942	CHAP domain
C2E56_RS01380	COG0433	COG0433 Predicted ATPase
C2E56_RS01425	COG1674	ftsk spoiiie
C2E56_RS01475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2E56_RS01490	COG1196	nuclear chromosome segregation
C2E56_RS01550	COG1396	sequence-specific DNA binding
C2E56_RS01555	COG2814	Major facilitator Superfamily
C2E56_RS01565	COG1732	Glycine betaine
C2E56_RS01740	COG1695	Transcriptional regulator
C2E56_RS01755	COG1755	Isoprenylcysteine carboxyl methyltransferase
C2E56_RS01775	COG4224	UPF0291 protein
C2E56_RS01795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2E56_RS01800	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2E56_RS01820	COG1131	(ABC) transporter
C2E56_RS01830	COG2190	(PTS) system
C2E56_RS01830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E56_RS01830	COG1263	PTS System
C2E56_RS01845	COG0275	rRNA processing
C2E56_RS01855	COG0768	penicillin binding
C2E56_RS01865	COG0513	Belongs to the DEAD box helicase family
C2E56_RS01880	COG1126	abc transporter atp-binding protein
C2E56_RS01890	COG0492	ferredoxin-NADP+ reductase activity
C2E56_RS01895	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2E56_RS01905	COG3579	cysteine-type endopeptidase activity
C2E56_RS01910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2E56_RS01920	COG4474	Belongs to the UPF0398 family
C2E56_RS01935	COG0116	Belongs to the methyltransferase superfamily
C2E56_RS01955	COG1131	(ABC) transporter
C2E56_RS01965	COG4585	Histidine kinase
C2E56_RS01970	COG2197	response regulator
C2E56_RS01990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2E56_RS02000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2E56_RS02000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2E56_RS02010	COG2815	serine threonine protein kinase
C2E56_RS02010	COG0515	serine threonine protein kinase
C2E56_RS02020	COG4585	Histidine kinase
C2E56_RS02025	COG2197	response regulator
C2E56_RS02035	COG1098	S1 RNA binding domain
C2E56_RS02040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2E56_RS02045	COG1349	DNA-binding transcription factor activity
C2E56_RS02055	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2E56_RS02065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E56_RS02090	COG1739	Uncharacterized protein family UPF0029
C2E56_RS02095	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2E56_RS02100	COG1040	competence protein
C2E56_RS02135	COG0527	aspartate kinase activity
C2E56_RS02140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2E56_RS02145	COG1024	Enoyl-CoA hydratase
C2E56_RS02165	COG2070	2-Nitropropane dioxygenase
C2E56_RS02170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2E56_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
C2E56_RS02180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2E56_RS02195	COG0439	Biotin carboxylase
C2E56_RS02230	COG3716	PTS system mannose fructose sorbose family IID component
C2E56_RS02235	COG3715	PTS system
C2E56_RS02245	COG0561	phosphatase activity
C2E56_RS02260	COG2252	PERMEase
C2E56_RS02265	COG0802	atpase or kinase
C2E56_RS02275	COG1316	TRANSCRIPTIONal
C2E56_RS02285	COG0537	adenosine 5'-monophosphoramidase activity
C2E56_RS02300	COG1131	(ABC) transporter
C2E56_RS02305	COG4473	ABC transporter
C2E56_RS02325	COG0779	Required for maturation of 30S ribosomal subunits
C2E56_RS02330	COG0195	Participates in both transcription termination and antitermination
C2E56_RS02335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2E56_RS02375	COG2860	membrane
C2E56_RS02385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E56_RS02385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E56_RS02390	COG1832	CoA-binding protein
C2E56_RS02410	COG5002	protein histidine kinase activity
C2E56_RS02430	COG1268	BioY protein
C2E56_RS02435	COG1234	tRNA 3'-trailer cleavage
C2E56_RS02455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2E56_RS02460	COG0705	Rhomboid family
C2E56_RS02460	COG0457	Tetratricopeptide repeat
C2E56_RS02465	COG1744	ABC transporter substrate-binding protein PnrA-like
C2E56_RS02470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2E56_RS02485	COG0706	membrane insertase activity
C2E56_RS02545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2E56_RS02555	COG2153	protein acetylation
C2E56_RS02565	COG1442	glycosyl transferase family 8
C2E56_RS02565	COG1216	Glycosyl transferase, family 2
C2E56_RS02605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2E56_RS02615	COG0789	Transcriptional regulator
C2E56_RS02620	COG1063	alcohol dehydrogenase
C2E56_RS02625	COG0656	L-ascorbic acid biosynthetic process
C2E56_RS02665	COG2226	methyltransferase
C2E56_RS02675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E56_RS02680	COG3414	Phosphotransferase system galactitol-specific IIB component
C2E56_RS02685	COG3775	system Galactitol-specific IIC component
C2E56_RS02690	COG0235	Class ii aldolase
C2E56_RS02700	COG3775	system Galactitol-specific IIC component
C2E56_RS02705	COG3414	Phosphotransferase system galactitol-specific IIB component
C2E56_RS02710	COG2207	Transcriptional regulator
C2E56_RS02720	COG1175	transmembrane transport
C2E56_RS02725	COG0395	ABC-type sugar transport system, permease component
C2E56_RS02735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2E56_RS02745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2E56_RS02750	COG2017	converts alpha-aldose to the beta-anomer
C2E56_RS02790	COG0673	inositol 2-dehydrogenase activity
C2E56_RS02800	COG2315	Protein conserved in bacteria
C2E56_RS02805	COG2502	aspartate--ammonia ligase
C2E56_RS02815	COG0742	ribosomal rna small subunit methyltransferase
C2E56_RS02830	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2E56_RS02835	COG0737	Belongs to the 5'-nucleotidase family
C2E56_RS02840	COG4470	Protein conserved in bacteria
C2E56_RS02855	COG1132	(ABC) transporter
C2E56_RS02860	COG1132	(ABC) transporter
C2E56_RS02865	COG0512	Glutamine amidotransferase of anthranilate synthase
C2E56_RS02870	COG1268	BioY protein
C2E56_RS02875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2E56_RS02895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2E56_RS02910	COG1940	carbohydrate kinase activity
C2E56_RS02915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2E56_RS02955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2E56_RS02965	COG0762	integral membrane protein
C2E56_RS02970	COG2302	S4 RNA-binding domain
C2E56_RS02975	COG3599	regulation of cell shape
C2E56_RS02980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2E56_RS02990	COG0494	nUDIX hydrolase
C2E56_RS02995	COG0542	response to heat
C2E56_RS03000	COG4703	Protein of unknown function (DUF1797)
C2E56_RS03005	COG0765	amino acid transport
C2E56_RS03010	COG1126	abc transporter atp-binding protein
C2E56_RS03015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2E56_RS03025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2E56_RS03030	COG1570	exodeoxyribonuclease VII activity
C2E56_RS03045	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2E56_RS03050	COG1438	arginine binding
C2E56_RS03055	COG0497	DNA recombination
C2E56_RS03060	COG1307	EDD domain protein, DegV family
C2E56_RS03065	COG2755	lipolytic protein G-D-S-L family
C2E56_RS03110	COG1078	dGTPase activity
C2E56_RS03135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2E56_RS03145	COG2884	Cell division ATP-binding protein ftsE
C2E56_RS03150	COG2177	Part of the ABC transporter FtsEX involved in
C2E56_RS03170	COG1199	ATP-dependent helicase activity
C2E56_RS03170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2E56_RS03175	COG0436	Aminotransferase
C2E56_RS03225	COG0254	rRNA binding
C2E56_RS03230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2E56_RS03235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2E56_RS03240	COG0716	FMN binding
C2E56_RS03245	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2E56_RS03245	COG1605	Chorismate mutase
C2E56_RS03250	COG0038	chloride channel
C2E56_RS03305	COG1136	(ABC) transporter
C2E56_RS03320	COG5002	protein histidine kinase activity
C2E56_RS03330	COG3237	CsbD-like
C2E56_RS03340	COG0772	Belongs to the SEDS family
C2E56_RS03360	COG0560	Phosphoserine phosphatase
C2E56_RS03480	COG1316	TRANSCRIPTIONal
C2E56_RS03485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2E56_RS03525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2E56_RS03530	COG4555	ABC transporter
C2E56_RS03560	COG1011	Hydrolase
C2E56_RS03570	COG5002	protein histidine kinase activity
C2E56_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
C2E56_RS03590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2E56_RS03595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2E56_RS03615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2E56_RS03620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2E56_RS03645	COG3590	peptidase
C2E56_RS03670	COG1136	(ABC) transporter
C2E56_RS03685	COG0586	Pfam SNARE associated Golgi protein
C2E56_RS03690	COG4619	ABC transporter
C2E56_RS03695	COG0390	transport system, permease component
C2E56_RS03705	COG0583	DNA-binding transcription factor activity
C2E56_RS03715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2E56_RS03720	COG2211	Major facilitator Superfamily
C2E56_RS03730	COG3250	beta-galactosidase activity
C2E56_RS03735	COG2186	Transcriptional regulator
C2E56_RS03740	COG0800	Aldolase
C2E56_RS03745	COG1904	glucuronate isomerase
C2E56_RS03750	COG1312	Catalyzes the dehydration of D-mannonate
C2E56_RS03755	COG1028	Short-chain dehydrogenase reductase Sdr
C2E56_RS03775	COG1609	Transcriptional regulator
C2E56_RS03790	COG0438	transferase activity, transferring glycosyl groups
C2E56_RS03815	COG0765	amino acid transport
C2E56_RS03820	COG0765	amino acid transport
C2E56_RS03825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E56_RS03830	COG1126	abc transporter atp-binding protein
C2E56_RS03835	COG0745	RESPONSE REGULATOR receiver
C2E56_RS03840	COG5002	protein histidine kinase activity
C2E56_RS03845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2E56_RS03850	COG2832	Protein of unknown function (DUF454)
C2E56_RS03860	COG1196	nuclear chromosome segregation
C2E56_RS03865	COG0561	phosphatase activity
C2E56_RS03870	COG0561	phosphatase activity
C2E56_RS03875	COG0552	protein localization to endoplasmic reticulum
C2E56_RS03880	COG3689	TIGRFAM TIGR03943 family protein
C2E56_RS03885	COG0701	Predicted permease
C2E56_RS03900	COG2183	response to ionizing radiation
C2E56_RS03905	COG3091	SprT-like family
C2E56_RS03910	COG1983	PspC domain protein
C2E56_RS03950	COG4443	Transcriptional Coactivator p15 (PC4)
C2E56_RS03960	COG1914	H( )-stimulated, divalent metal cation uptake system
C2E56_RS03985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2E56_RS04000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2E56_RS04025	COG1164	Oligoendopeptidase f
C2E56_RS04035	COG0772	Belongs to the SEDS family
C2E56_RS04055	COG0768	penicillin binding
C2E56_RS04070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2E56_RS04075	COG2223	nitrite transmembrane transporter activity
C2E56_RS04100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2E56_RS04105	COG2011	ABC-type metal ion transport system permease component
C2E56_RS04110	COG1464	Belongs to the NlpA lipoprotein family
C2E56_RS04115	COG0513	Belongs to the DEAD box helicase family
C2E56_RS04125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2E56_RS04130	COG0204	Acyl-transferase
C2E56_RS04135	COG1555	photosystem II stabilization
C2E56_RS04135	COG1596	polysaccharide export
C2E56_RS04140	COG0658	competence protein
C2E56_RS04140	COG2333	competence protein COMEC
C2E56_RS04145	COG0561	phosphatase activity
C2E56_RS04150	COG1609	Transcriptional regulator
C2E56_RS04155	COG0657	acetylesterase activity
C2E56_RS04160	COG2226	methyltransferase
C2E56_RS04170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2E56_RS04175	COG3711	transcriptional antiterminator
C2E56_RS04180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E56_RS04180	COG2190	(PTS) system
C2E56_RS04180	COG1263	PTS System
C2E56_RS04190	COG3835	regulator
C2E56_RS04195	COG1929	Belongs to the glycerate kinase type-1 family
C2E56_RS04200	COG2610	gluconate transmembrane transporter activity
C2E56_RS04210	COG1846	Transcriptional regulator
C2E56_RS04215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2E56_RS04230	COG0435	Glutathione S-transferase
C2E56_RS04235	COG1187	pseudouridine synthase activity
C2E56_RS04255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2E56_RS04270	COG4894	glucomannan catabolic process
C2E56_RS04280	COG1811	Na channel or pump
C2E56_RS04285	COG1442	glycosyl transferase family 8
C2E56_RS04300	COG1476	TRANSCRIPTIONal
C2E56_RS04315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2E56_RS04320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2E56_RS04325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2E56_RS04340	COG1012	belongs to the aldehyde dehydrogenase family
C2E56_RS04345	COG0726	polysaccharide deacetylase
C2E56_RS04350	COG0513	Belongs to the DEAD box helicase family
C2E56_RS04360	COG1956	GAF domain-containing protein
C2E56_RS04365	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2E56_RS04375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2E56_RS04375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2E56_RS04380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2E56_RS04405	COG4721	ABC-type cobalt transport system, permease component
C2E56_RS04410	COG1122	ATPase activity
C2E56_RS04420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2E56_RS04440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2E56_RS04450	COG4109	DRTGG domain
C2E56_RS04455	COG0024	Methionine aminopeptidase
C2E56_RS04465	COG2246	polysaccharide biosynthetic process
C2E56_RS04470	COG4708	membrane
C2E56_RS04475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2E56_RS04480	COG1597	lipid kinase activity
C2E56_RS04485	COG1523	belongs to the glycosyl hydrolase 13 family
C2E56_RS04495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2E56_RS04500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2E56_RS04505	COG0297	glycogen (starch) synthase activity
C2E56_RS04525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2E56_RS04545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2E56_RS04580	COG0072	phenylalanine-tRNA ligase activity
C2E56_RS04580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E56_RS04585	COG2321	neutral zinc metallopeptidase
C2E56_RS04595	COG1074	ATP-dependent DNA helicase activity
C2E56_RS04605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2E56_RS04615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2E56_RS04620	COG0022	dehydrogenase e1 component
C2E56_RS04620	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2E56_RS04625	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2E56_RS04635	COG0095	Lipoate-protein ligase
C2E56_RS04640	COG3442	glutamine amidotransferase
C2E56_RS04645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2E56_RS04650	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2E56_RS04675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2E56_RS04685	COG0647	UMP catabolic process
C2E56_RS04695	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C2E56_RS04700	COG1518	maintenance of DNA repeat elements
C2E56_RS04705	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C2E56_RS04730	COG1418	mRNA catabolic process
C2E56_RS04735	COG0456	acetyltransferase
C2E56_RS04745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2E56_RS04775	COG1131	(ABC) transporter
C2E56_RS04780	COG1725	Transcriptional regulator
C2E56_RS04795	COG0469	pyruvate kinase activity
C2E56_RS04805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2E56_RS04810	COG2824	Alkylphosphonate utilization operon protein PhnA
C2E56_RS04815	COG0765	amino acid transport
C2E56_RS04820	COG1126	abc transporter atp-binding protein
C2E56_RS04840	COG2813	Specifically methylates the guanine in position
C2E56_RS04850	COG1744	ABC transporter substrate-binding protein PnrA-like
C2E56_RS04885	COG3764	Sortase (surface protein transpeptidase)
C2E56_RS04890	COG0346	lactoylglutathione lyase activity
C2E56_RS04915	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C2E56_RS04925	COG1464	Belongs to the NlpA lipoprotein family
C2E56_RS04940	COG1136	(ABC) transporter
C2E56_RS04950	COG0745	RESPONSE REGULATOR receiver
C2E56_RS04955	COG5002	protein histidine kinase activity
C2E56_RS04965	COG4166	transmembrane transport
C2E56_RS04980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2E56_RS04985	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C2E56_RS04990	COG5002	protein histidine kinase activity
C2E56_RS04995	COG0745	RESPONSE REGULATOR receiver
C2E56_RS05005	COG0704	Plays a role in the regulation of phosphate uptake
C2E56_RS05020	COG0581	inorganic phosphate transmembrane transporter activity
C2E56_RS05025	COG0573	inorganic phosphate transmembrane transporter activity
C2E56_RS05030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2E56_RS05035	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2E56_RS05035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2E56_RS05040	COG0483	inositol monophosphate 1-phosphatase activity
C2E56_RS05045	COG4476	Belongs to the UPF0223 family
C2E56_RS05050	COG1393	Belongs to the ArsC family
C2E56_RS05055	COG0196	riboflavin kinase activity
C2E56_RS05090	COG1136	(ABC) transporter
C2E56_RS05095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2E56_RS05100	COG0758	DNA mediated transformation
C2E56_RS05105	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2E56_RS05110	COG4604	ABC transporter, ATP-binding protein
C2E56_RS05115	COG4605	iron ion homeostasis
C2E56_RS05120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2E56_RS05135	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2E56_RS05140	COG1376	ErfK ybiS ycfS ynhG family protein
C2E56_RS05145	COG1966	Carbon starvation protein
C2E56_RS05150	COG3279	Response regulator of the LytR AlgR family
C2E56_RS05155	COG3275	phosphorelay sensor kinase activity
C2E56_RS05200	COG3942	CHAP domain
C2E56_RS05200	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E56_RS05335	COG1511	domain protein
C2E56_RS05335	COG0842	Transport permease protein
C2E56_RS05365	COG0505	Belongs to the CarA family
C2E56_RS05375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2E56_RS05395	COG0488	(ABC) transporter
C2E56_RS05405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2E56_RS05415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2E56_RS05465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2E56_RS05470	COG4684	Psort location CytoplasmicMembrane, score
C2E56_RS05475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2E56_RS05485	COG1132	(ABC) transporter
C2E56_RS05515	COG2890	protein-(glutamine-N5) methyltransferase activity
C2E56_RS05545	COG0431	NADPH-dependent FMN reductase
C2E56_RS05545	COG1053	succinate dehydrogenase
C2E56_RS05545	COG3976	FMN-binding domain protein
C2E56_RS05555	COG2233	PERMEase
C2E56_RS05570	COG0477	Major facilitator Superfamily
C2E56_RS05585	COG4221	oxidoreductase activity
C2E56_RS05590	COG0280	phosphate acetyltransferase
C2E56_RS05595	COG0564	pseudouridine synthase activity
C2E56_RS05605	COG2357	RelA SpoT domain protein
C2E56_RS05615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2E56_RS05620	COG1104	cysteine desulfurase activity
C2E56_RS05640	COG0628	permease
C2E56_RS05645	COG2723	6-phospho-beta-galactosidase activity
C2E56_RS05655	COG0561	phosphatase activity
C2E56_RS05675	COG1388	LysM domain
C2E56_RS05675	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2E56_RS05740	COG0740	serine-type endopeptidase activity
C2E56_RS05745	COG4695	Portal protein
C2E56_RS05785	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2E56_RS05805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2E56_RS05850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E56_RS05850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E56_RS05900	COG4372	Transposase
C2E56_RS05955	COG0038	chloride channel
C2E56_RS05960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2E56_RS05965	COG1177	transmembrane transport
C2E56_RS05970	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2E56_RS06005	COG0285	dihydrofolate synthase activity
C2E56_RS06010	COG2962	Rard protein
C2E56_RS06025	COG0726	polysaccharide deacetylase
C2E56_RS06030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2E56_RS06035	COG1012	belongs to the aldehyde dehydrogenase family
C2E56_RS06110	COG2261	transglycosylase associated protein
C2E56_RS06135	COG1115	amino acid carrier protein
C2E56_RS06140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2E56_RS06150	COG1346	cytolysis
C2E56_RS06225	COG1598	PFAM Uncharacterised protein family UPF0150
C2E56_RS06255	COG1674	ftsk spoiiie
C2E56_RS06265	COG2946	Replication initiation factor
C2E56_RS06295	COG0741	lytic transglycosylase activity
C2E56_RS06295	COG0791	NLP P60 protein
C2E56_RS06480	COG3422	double-strand break repair
C2E56_RS06485	COG3620	sequence-specific DNA binding
C2E56_RS06495	COG4974	Belongs to the 'phage' integrase family
C2E56_RS06505	COG0539	negative regulation of cytoplasmic translation
C2E56_RS06525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2E56_RS06535	COG0187	DNA topoisomerase II activity
C2E56_RS06540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2E56_RS06570	COG2089	acid synthase
C2E56_RS06585	COG1442	glycosyl transferase family 8
C2E56_RS06585	COG1216	Glycosyl transferase, family 2
C2E56_RS06590	COG1442	glycosyl transferase family 8
C2E56_RS06590	COG1216	Glycosyl transferase, family 2
C2E56_RS06605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2E56_RS06615	COG0489	protein tyrosine kinase activity
C2E56_RS06655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2E56_RS06690	COG3842	ATPase activity
C2E56_RS06710	COG3527	Alpha-acetolactate decarboxylase
C2E56_RS06715	COG0028	Belongs to the TPP enzyme family
C2E56_RS06720	COG0457	Tetratricopeptide repeat
C2E56_RS06725	COG0628	permease
C2E56_RS06735	COG1051	belongs to the nudix hydrolase family
C2E56_RS06740	COG5492	domain, Protein
C2E56_RS06745	COG1088	dTDP-glucose 4,6-dehydratase activity
C2E56_RS06755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2E56_RS06760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2E56_RS06770	COG2384	SAM-dependent methyltransferase
C2E56_RS06780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2E56_RS06790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2E56_RS06790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2E56_RS06795	COG0300	oxidoreductase activity
C2E56_RS06840	COG1573	uracil-dna glycosylase
C2E56_RS06845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2E56_RS06855	COG0584	glycerophosphoryl diester phosphodiesterase
C2E56_RS06870	COG0534	Mate efflux family protein
C2E56_RS06895	COG4974	Belongs to the 'phage' integrase family
C2E56_RS06905	COG1396	sequence-specific DNA binding
C2E56_RS06925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E56_RS06925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E56_RS06935	COG3711	transcriptional antiterminator
C2E56_RS06940	COG3684	Belongs to the aldolase LacD family
C2E56_RS06945	COG1105	Belongs to the carbohydrate kinase PfkB family
C2E56_RS06960	COG1349	DNA-binding transcription factor activity
C2E56_RS06985	COG0210	DNA helicase
C2E56_RS07000	COG0542	response to heat
C2E56_RS07005	COG1396	sequence-specific DNA binding
C2E56_RS07160	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2E56_RS07185	COG2040	homocysteine
C2E56_RS07190	COG0833	amino acid
C2E56_RS07220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2E56_RS07230	COG3425	synthase
C2E56_RS07245	COG1272	protein, Hemolysin III
C2E56_RS07290	COG0745	RESPONSE REGULATOR receiver
C2E56_RS07295	COG2357	RelA SpoT domain protein
C2E56_RS07300	COG1132	(ABC) transporter
C2E56_RS07315	COG0737	Belongs to the 5'-nucleotidase family
C2E56_RS07320	COG0242	peptide deformylase activity
C2E56_RS07325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2E56_RS07335	COG1132	(ABC) transporter
C2E56_RS07340	COG1132	(ABC) transporter
C2E56_RS07350	COG0488	(ABC) transporter
C2E56_RS07355	COG0617	tRNA 3'-terminal CCA addition
C2E56_RS07380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E56_RS07380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2E56_RS07380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2E56_RS07385	COG1105	Belongs to the carbohydrate kinase PfkB family
C2E56_RS07390	COG1349	DNA-binding transcription factor activity
C2E56_RS07395	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E56_RS07395	COG1388	LysM domain
C2E56_RS07425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2E56_RS07445	COG1837	Belongs to the UPF0109 family
C2E56_RS07455	COG0577	efflux transmembrane transporter activity
C2E56_RS07460	COG1136	(ABC) transporter
C2E56_RS07465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2E56_RS07475	COG0505	Belongs to the CarA family
C2E56_RS07485	COG0564	pseudouridine synthase activity
C2E56_RS07495	COG0583	DNA-binding transcription factor activity
C2E56_RS07500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2E56_RS07520	COG0301	tRNA thio-modification
C2E56_RS07525	COG1104	cysteine desulfurase activity
C2E56_RS07535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2E56_RS07560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2E56_RS07565	COG1368	sulfuric ester hydrolase activity
C2E56_RS07610	COG2244	polysaccharide biosynthetic process
C2E56_RS07615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2E56_RS07620	COG1120	ATPase activity
C2E56_RS07625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2E56_RS07630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2E56_RS07635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2E56_RS07650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2E56_RS07655	COG1253	flavin adenine dinucleotide binding
C2E56_RS07660	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2E56_RS07665	COG1242	4 iron, 4 sulfur cluster binding
C2E56_RS07670	COG0671	phosphoesterase, PA-phosphatase related
C2E56_RS07675	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2E56_RS07705	COG0681	Belongs to the peptidase S26 family
C2E56_RS07715	COG0297	glycogen (starch) synthase activity
C2E56_RS07755	COG3475	LICD family
C2E56_RS07770	COG0463	Glycosyl transferase, family 2
C2E56_RS07775	COG1215	transferase activity, transferring glycosyl groups
C2E56_RS07785	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2E56_RS07790	COG2151	metal-sulfur cluster biosynthetic enzyme
C2E56_RS07795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2E56_RS07800	COG0358	DNA primase activity
C2E56_RS07805	COG1970	mechanosensitive ion channel activity
C2E56_RS07820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E56_RS07825	COG0004	ammonium transporteR
C2E56_RS07845	COG2271	Major facilitator Superfamily
C2E56_RS07850	COG0058	SHG alpha-glucan phosphorylase activity
C2E56_RS07855	COG1640	4-alpha-glucanotransferase
C2E56_RS07860	COG1609	Transcriptional regulator
C2E56_RS07870	COG1175	transmembrane transport
C2E56_RS07875	COG3833	ABC-type maltose transport systems, permease component
C2E56_RS07900	COG0438	transferase activity, transferring glycosyl groups
C2E56_RS07905	COG0653	protein targeting
C2E56_RS07925	COG0201	protein transport
C2E56_RS07930	COG1442	glycosyl transferase family 8
C2E56_RS07935	COG1216	Glycosyl transferase, family 2
C2E56_RS07935	COG1442	glycosyl transferase family 8
C2E56_RS07940	COG1442	glycosyl transferase family 8
C2E56_RS07945	COG1442	glycosyl transferase family 8
C2E56_RS07950	COG1442	glycosyl transferase family 8
C2E56_RS07980	COG0765	amino acid transport
C2E56_RS07985	COG1126	abc transporter atp-binding protein
C2E56_RS08005	COG2309	aminopeptidase activity
C2E56_RS08020	COG1187	pseudouridine synthase activity
C2E56_RS08025	COG0656	L-ascorbic acid biosynthetic process
C2E56_RS08030	COG0778	Nitroreductase
C2E56_RS08035	COG0346	lactoylglutathione lyase activity
C2E56_RS08040	COG0463	Glycosyl transferase, family 2
C2E56_RS08045	COG1113	amino acid transport
C2E56_RS08055	COG0557	exoribonuclease II activity
C2E56_RS08070	COG2814	Major facilitator Superfamily
C2E56_RS08080	COG1131	(ABC) transporter
C2E56_RS08095	COG1396	sequence-specific DNA binding
C2E56_RS08135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2E56_RS08160	COG1702	phosphate starvation-inducible protein PhoH
C2E56_RS08200	COG0444	Belongs to the ABC transporter superfamily
C2E56_RS08205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2E56_RS08210	COG0601	transmembrane transport
C2E56_RS08215	COG0747	negative chemotaxis
C2E56_RS08225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2E56_RS08235	COG1473	amidohydrolase
C2E56_RS08240	COG0583	DNA-binding transcription factor activity
C2E56_RS08250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2E56_RS08255	COG1674	ftsk spoiiie
C2E56_RS08260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2E56_RS08285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2E56_RS08315	COG0673	inositol 2-dehydrogenase activity
C2E56_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
C2E56_RS08350	COG1215	transferase activity, transferring glycosyl groups
C2E56_RS08375	COG1114	Component of the transport system for branched-chain amino acids
C2E56_RS08380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E56_RS08380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E56_RS08395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E56_RS08405	COG0708	Exodeoxyribonuclease III
C2E56_RS08410	COG1393	Belongs to the ArsC family
C2E56_RS08415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2E56_RS08420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2E56_RS08430	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2E56_RS08450	COG0470	DNA polymerase III
C2E56_RS08460	COG0517	IMP dehydrogenase activity
C2E56_RS08465	COG0410	ABC transporter
C2E56_RS08470	COG0411	ABC transporter
C2E56_RS08480	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2E56_RS08505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2E56_RS08515	COG0531	amino acid
C2E56_RS08520	COG0569	domain protein
C2E56_RS08525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2E56_RS08535	COG1187	pseudouridine synthase activity
C2E56_RS08565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2E56_RS08570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2E56_RS08585	COG1827	regulation of RNA biosynthetic process
C2E56_RS08600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2E56_RS08605	COG1254	Belongs to the acylphosphatase family
C2E56_RS08615	COG0765	amino acid transport
C2E56_RS08620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E56_RS08635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2E56_RS08655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2E56_RS08665	COG1484	DNA-dependent DNA replication
C2E56_RS08680	COG5002	protein histidine kinase activity
C2E56_RS08685	COG0745	RESPONSE REGULATOR receiver
C2E56_RS08695	COG0501	Belongs to the peptidase M48B family
C2E56_RS08700	COG1704	LemA family
C2E56_RS08705	COG0357	Ribosomal RNA small subunit methyltransferase G
C2E56_RS08710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2E56_RS08715	COG0569	domain protein
C2E56_RS08740	COG1114	Component of the transport system for branched-chain amino acids
C2E56_RS08745	COG1063	alcohol dehydrogenase
C2E56_RS08770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E56_RS08775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2E56_RS08785	COG2376	Dihydroxyacetone kinase
C2E56_RS08790	COG1309	transcriptional regulator
C2E56_RS08795	COG2376	Dihydroxyacetone kinase
C2E56_RS08800	COG1461	Dihydroxyacetone kinase
C2E56_RS08805	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C2E56_RS08810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2E56_RS08820	COG0789	Transcriptional regulator
C2E56_RS08825	COG1323	Belongs to the UPF0348 family
C2E56_RS08835	COG2226	methyltransferase
C2E56_RS08840	COG0799	negative regulation of ribosome biogenesis
C2E56_RS08850	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2E56_RS08855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2E56_RS08860	COG1534	Rna-binding protein
C2E56_RS08865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2E56_RS08870	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2E56_RS08885	COG0154	amidase activity
C2E56_RS08890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2E56_RS08895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2E56_RS08895	COG0574	Belongs to the PEP-utilizing enzyme family
C2E56_RS08905	COG0517	IMP dehydrogenase activity
C2E56_RS08915	COG1335	isochorismatase
C2E56_RS08920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2E56_RS08925	COG0436	Aminotransferase
C2E56_RS08930	COG0589	response to stress
C2E56_RS08935	COG0561	phosphatase activity
C2E56_RS08940	COG0252	asparaginase activity
C2E56_RS08950	COG4989	oxidoreductase activity
C2E56_RS08955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2E56_RS08960	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E56_RS08960	COG3942	CHAP domain
C2E56_RS08975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2E56_RS08985	COG1482	cell wall glycoprotein biosynthetic process
C2E56_RS08990	COG1940	carbohydrate kinase activity
C2E56_RS08995	COG1263	PTS System
C2E56_RS08995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E56_RS08995	COG2190	(PTS) system
C2E56_RS09000	COG1621	beta-fructofuranosidase activity
C2E56_RS09005	COG1609	Transcriptional regulator
C2E56_RS09045	COG2131	deaminase
C2E56_RS09050	COG0006	proline dipeptidase activity
C2E56_RS09060	COG2814	Major facilitator Superfamily
C2E56_RS09085	COG0629	single-stranded DNA binding
C2E56_RS09095	COG1194	a g-specific adenine glycosylase
C2E56_RS09105	COG3118	belongs to the thioredoxin family
C2E56_RS09130	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2E56_RS09135	COG0681	Belongs to the peptidase S26 family
C2E56_RS09140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2E56_RS09155	COG1882	Formate acetyltransferase
C2E56_RS09160	COG3576	pyridoxamine 5-phosphate
C2E56_RS09165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2E56_RS09180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2E56_RS09190	COG2814	Major facilitator Superfamily
C2E56_RS09195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2E56_RS09210	COG0142	geranyltranstransferase activity
C2E56_RS09215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2E56_RS09220	COG4988	ABC transporter
C2E56_RS09225	COG1294	oxidase, subunit
C2E56_RS09230	COG1271	oxidase subunit
C2E56_RS09235	COG1252	NADH dehydrogenase
C2E56_RS09270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2E56_RS09290	COG2081	HI0933 family
C2E56_RS09315	COG0456	acetyltransferase
C2E56_RS09320	COG1214	PFAM Peptidase M22, glycoprotease
C2E56_RS09335	COG3942	CHAP domain
C2E56_RS09340	COG0174	glutamine synthetase
C2E56_RS09345	COG0789	Transcriptional regulator
C2E56_RS09360	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C2E56_RS09385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2E56_RS09395	COG1322	Protein conserved in bacteria
C2E56_RS09410	COG1162	GTPase activity
C2E56_RS09435	COG0084	hydrolase, TatD family'
C2E56_RS09460	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2E56_RS09470	COG1696	Membrane protein involved in D-alanine export
C2E56_RS09485	COG5002	protein histidine kinase activity
C2E56_RS09490	COG0745	RESPONSE REGULATOR receiver
C2E56_RS09510	COG3448	diguanylate cyclase activity
C2E56_RS09510	COG4175	Glycine betaine
C2E56_RS09515	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C2E56_RS09535	COG1070	Carbohydrate kinase
C2E56_RS09545	COG3775	system Galactitol-specific IIC component
C2E56_RS09550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2E56_RS09560	COG1609	Transcriptional regulator
C2E56_RS09565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2E56_RS09595	COG3037	sugar-specific permease SgaT UlaA
C2E56_RS09610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2E56_RS09625	COG2918	glutathione biosynthetic process
C2E56_RS09625	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2E56_RS09645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2E56_RS09650	COG1428	Deoxynucleoside kinase
C2E56_RS09660	COG0542	response to heat
C2E56_RS09665	COG4463	regulation of RNA biosynthetic process
C2E56_RS09680	COG0052	Belongs to the universal ribosomal protein uS2 family
C2E56_RS09685	COG0450	alkyl hydroperoxide reductase
C2E56_RS09700	COG0025	NhaP-type Na H and K H
C2E56_RS09710	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2E56_RS09715	COG3590	peptidase
C2E56_RS09740	COG1609	Transcriptional regulator
C2E56_RS09750	COG3716	PTS system mannose fructose sorbose family IID component
C2E56_RS09755	COG3715	PTS system
C2E56_RS09760	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E56_RS09765	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2E56_RS09775	COG1028	Short-chain dehydrogenase reductase Sdr
C2E56_RS09810	COG2176	DNA-directed DNA polymerase activity
C2E56_RS09815	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E56_RS09815	COG1388	LysM domain
C2E56_RS09830	COG4589	Belongs to the CDS family
C2E56_RS09835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2E56_RS09840	COG1862	Preprotein translocase
C2E56_RS09850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2E56_RS09860	COG3842	ATPase activity
C2E56_RS09875	COG3684	Belongs to the aldolase LacD family
C2E56_RS09885	COG0698	ribose 5-phosphate isomerase
C2E56_RS09890	COG0698	ribose 5-phosphate isomerase
C2E56_RS09930	COG1490	D-aminoacyl-tRNA deacylase activity
C2E56_RS09940	COG0737	Belongs to the 5'-nucleotidase family
C2E56_RS09950	COG1363	Peptidase, m42
C2E56_RS09965	COG2207	Transcriptional regulator
C2E56_RS09965	COG4753	response regulator
C2E56_RS09970	COG2972	Histidine kinase
C2E56_RS09975	COG3716	PTS system mannose fructose sorbose family IID component
C2E56_RS09980	COG3715	PTS system
C2E56_RS10005	COG1131	(ABC) transporter
C2E56_RS10015	COG3279	Response regulator of the LytR AlgR family
C2E56_RS10025	COG1263	PTS System
C2E56_RS10025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E56_RS10025	COG2190	(PTS) system
C2E56_RS10030	COG5002	protein histidine kinase activity
C2E56_RS10045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2E56_RS10050	COG0581	inorganic phosphate transmembrane transporter activity
C2E56_RS10055	COG0573	inorganic phosphate transmembrane transporter activity
C2E56_RS10060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2E56_RS10070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2E56_RS10075	COG2264	protein methyltransferase activity
C2E56_RS10085	COG0789	Transcriptional regulator
C2E56_RS10120	COG0456	acetyltransferase
C2E56_RS10125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2E56_RS10165	COG1131	(ABC) transporter
C2E56_RS10175	COG1396	sequence-specific DNA binding
C2E56_RS10185	COG1694	Mazg nucleotide pyrophosphohydrolase
C2E56_RS10200	COG2897	thiosulfate sulfurtransferase activity
C2E56_RS10215	COG0371	Dehydrogenase
C2E56_RS10225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2E56_RS10225	COG0646	methionine synthase
C2E56_RS10230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2E56_RS10240	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2E56_RS10250	COG0745	RESPONSE REGULATOR receiver
C2E56_RS10255	COG2770	Histidine kinase
C2E56_RS10255	COG2205	protein histidine kinase activity
C2E56_RS10270	COG2814	Major facilitator Superfamily
C2E56_RS10275	COG4667	esterase of the alpha-beta hydrolase superfamily
C2E56_RS10300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2E56_RS10305	COG0564	pseudouridine synthase activity
C2E56_RS10325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2E56_RS10330	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C2E56_RS10350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2E56_RS10355	COG1116	anion transmembrane transporter activity
C2E56_RS10355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2E56_RS10365	COG0561	phosphatase activity
C2E56_RS10370	COG2514	catechol 2,3-dioxygenase activity
C2E56_RS10375	COG3022	response to hydroperoxide
C2E56_RS10380	COG0602	queuosine metabolic process
C2E56_RS10395	COG1328	CTP reductase activity
C2E56_RS10405	COG3906	Belongs to the UPF0473 family
C2E56_RS10420	COG1393	Belongs to the ArsC family
C2E56_RS10425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2E56_RS10435	COG2818	Glycosylase
C2E56_RS10480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2E56_RS10485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2E56_RS10490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2E56_RS10495	COG0124	histidyl-tRNA synthetase
C2E56_RS10515	COG0745	RESPONSE REGULATOR receiver
C2E56_RS10520	COG5002	protein histidine kinase activity
C2E56_RS10525	COG1288	antiporter activity
C2E56_RS10535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2E56_RS10540	COG3852	Histidine kinase
C2E56_RS10545	COG0784	Response regulator, receiver
C2E56_RS10550	COG0517	IMP dehydrogenase activity
C2E56_RS10550	COG1125	glycine betaine transport
C2E56_RS10555	COG1174	glycine betaine transport
C2E56_RS10560	COG0392	lysyltransferase activity
C2E56_RS10560	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2E56_RS10570	COG3759	membrane
C2E56_RS10600	COG0305	Participates in initiation and elongation during chromosome replication
C2E56_RS10620	COG2095	MarC family integral membrane protein
C2E56_RS10625	COG0482	sulfurtransferase activity
C2E56_RS10630	COG1760	l-serine dehydratase
C2E56_RS10635	COG1760	l-serine dehydratase
C2E56_RS10640	COG0741	lytic transglycosylase activity
C2E56_RS10645	COG1388	LysM domain
C2E56_RS10665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2E56_RS10670	COG0612	Peptidase, M16
C2E56_RS10675	COG0612	Peptidase, M16
C2E56_RS10680	COG2501	S4 domain
C2E56_RS10690	COG4975	Glucose uptake
C2E56_RS10710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2E56_RS10720	COG2235	arginine
C2E56_RS10740	COG0549	Belongs to the carbamate kinase family
C2E56_RS10745	COG0180	Tryptophanyl-tRNA synthetase
C2E56_RS10755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2E56_RS10760	COG0488	(ABC) transporter
C2E56_RS10765	COG4485	Bacterial membrane protein, YfhO
C2E56_RS10790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2E56_RS10795	COG1475	DNA binding