locus-tag	class	description
BB165_RS00175	COG0436	Aminotransferase
BB165_RS00190	COG0416	fatty acid biosynthetic process
BB165_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BB165_RS00200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BB165_RS00205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BB165_RS00215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BB165_RS00220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BB165_RS00230	COG0138	bifunctional purine biosynthesis protein purh
BB165_RS00245	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BB165_RS00255	COG1175	transmembrane transport
BB165_RS00260	COG0395	ABC-type sugar transport system, permease component
BB165_RS00275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BB165_RS00285	COG3458	cephalosporin-C deacetylase activity
BB165_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BB165_RS00320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BB165_RS00335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BB165_RS00345	COG2755	lipolytic protein G-D-S-L family
BB165_RS00345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BB165_RS00350	COG1454	alcohol dehydrogenase
BB165_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
BB165_RS00355	COG1064	alcohol dehydrogenase
BB165_RS00365	COG0534	Mate efflux family protein
BB165_RS00475	COG0201	protein transport
BB165_RS00480	COG0563	adenylate kinase activity
BB165_RS00495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BB165_RS00505	COG0202	RNA polymerase activity
BB165_RS00630	COG1705	Flagellar rod assembly protein muramidase FlgJ
BB165_RS00635	COG1420	regulation of RNA biosynthetic process
BB165_RS00645	COG0443	Heat shock 70 kDa protein
BB165_RS00650	COG0484	heat shock protein binding
BB165_RS00655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BB165_RS00660	COG0101	tRNA pseudouridine synthase activity
BB165_RS00665	COG0351	phosphomethylpyrimidine kinase
BB165_RS00670	COG4720	Psort location CytoplasmicMembrane, score
BB165_RS00680	COG0668	transmembrane transport
BB165_RS00685	COG0544	peptidyl-prolyl cis-trans isomerase activity
BB165_RS00710	COG0756	dUTP diphosphatase activity
BB165_RS00725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BB165_RS00730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BB165_RS00735	COG1879	ABC-type sugar transport system periplasmic component
BB165_RS00740	COG1172	Belongs to the binding-protein-dependent transport system permease family
BB165_RS00745	COG1129	ABC transporter
BB165_RS00750	COG1869	D-ribose catabolic process
BB165_RS00755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BB165_RS00760	COG1609	Transcriptional regulator
BB165_RS00770	COG0577	efflux transmembrane transporter activity
BB165_RS00775	COG1136	(ABC) transporter
BB165_RS00780	COG0745	RESPONSE REGULATOR receiver
BB165_RS00785	COG2205	protein histidine kinase activity
BB165_RS00790	COG0137	argininosuccinate synthase activity
BB165_RS00795	COG0165	Argininosuccinate lyase
BB165_RS00800	COG0191	fructose-bisphosphate aldolase activity
BB165_RS00820	COG1461	Dihydroxyacetone kinase
BB165_RS00835	COG1126	abc transporter atp-binding protein
BB165_RS00840	COG0765	amino acid transport
BB165_RS00860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BB165_RS00870	COG0719	Fe-S assembly protein
BB165_RS00875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BB165_RS00885	COG0719	Fe-S assembly protein
BB165_RS00890	COG1686	Belongs to the peptidase S11 family
BB165_RS00895	COG1686	Belongs to the peptidase S11 family
BB165_RS00900	COG4166	transmembrane transport
BB165_RS00905	COG0601	transmembrane transport
BB165_RS00910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BB165_RS00915	COG0444	Belongs to the ABC transporter superfamily
BB165_RS00920	COG4608	Belongs to the ABC transporter superfamily
BB165_RS00950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BB165_RS00960	COG1121	(ABC) transporter
BB165_RS00965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BB165_RS00975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BB165_RS00980	COG4499	WXG100 protein secretion system (Wss), protein YukC
BB165_RS00980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BB165_RS01005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BB165_RS01010	COG1459	type II secretion system
BB165_RS01030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BB165_RS01055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BB165_RS01060	COG1363	Peptidase, m42
BB165_RS01075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB165_RS01080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB165_RS01090	COG0629	single-stranded DNA binding
BB165_RS01095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BB165_RS01115	COG1346	cytolysis
BB165_RS01130	COG0601	transmembrane transport
BB165_RS01135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BB165_RS01140	COG1122	ATPase activity
BB165_RS01150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BB165_RS01150	COG1263	PTS System
BB165_RS01155	COG0366	Alpha amylase catalytic
BB165_RS01160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BB165_RS01175	COG3959	Transketolase, thiamine diphosphate binding domain
BB165_RS01180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BB165_RS01185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BB165_RS01195	COG1185	polyribonucleotide nucleotidyltransferase activity
BB165_RS01205	COG1045	serine acetyltransferase
BB165_RS01215	COG0215	cysteine-tRNA ligase activity
BB165_RS01220	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BB165_RS01250	COG1476	TRANSCRIPTIONal
BB165_RS01260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BB165_RS01270	COG4974	Belongs to the 'phage' integrase family
BB165_RS01385	COG1396	sequence-specific DNA binding
BB165_RS01390	COG2814	Major facilitator Superfamily
BB165_RS01405	COG1732	Glycine betaine
BB165_RS01505	COG0519	Catalyzes the synthesis of GMP from XMP
BB165_RS01550	COG1695	Transcriptional regulator
BB165_RS01565	COG1755	Isoprenylcysteine carboxyl methyltransferase
BB165_RS01570	COG0752	glycyl-tRNA synthetase alpha subunit
BB165_RS01580	COG0751	glycine-tRNA ligase activity
BB165_RS01605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BB165_RS01610	COG0446	pyridine nucleotide-disulphide oxidoreductase
BB165_RS01630	COG1131	(ABC) transporter
BB165_RS01640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BB165_RS01640	COG2190	(PTS) system
BB165_RS01640	COG1263	PTS System
BB165_RS01645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BB165_RS01650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BB165_RS01655	COG0275	rRNA processing
BB165_RS01665	COG0768	penicillin binding
BB165_RS01675	COG0513	Belongs to the DEAD box helicase family
BB165_RS01690	COG1126	abc transporter atp-binding protein
BB165_RS01700	COG0492	ferredoxin-NADP+ reductase activity
BB165_RS01705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BB165_RS01715	COG3579	cysteine-type endopeptidase activity
BB165_RS01720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BB165_RS01750	COG0116	Belongs to the methyltransferase superfamily
BB165_RS01760	COG1854	S-ribosylhomocysteine lyase activity
BB165_RS01765	COG4372	Transposase
BB165_RS01765	COG1418	mRNA catabolic process
BB165_RS01775	COG1131	(ABC) transporter
BB165_RS01785	COG4585	Histidine kinase
BB165_RS01790	COG2197	response regulator
BB165_RS01800	COG0194	GDP metabolic process
BB165_RS01810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BB165_RS01815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BB165_RS01820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BB165_RS01820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BB165_RS01830	COG0515	serine threonine protein kinase
BB165_RS01830	COG2815	serine threonine protein kinase
BB165_RS01840	COG4585	Histidine kinase
BB165_RS01845	COG2197	response regulator
BB165_RS01855	COG1098	S1 RNA binding domain
BB165_RS01860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BB165_RS01865	COG1349	DNA-binding transcription factor activity
BB165_RS01875	COG1447	Phosphotransferase system cellobiose-specific component IIA
BB165_RS01885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BB165_RS01890	COG1882	Formate acetyltransferase
BB165_RS01910	COG1739	Uncharacterized protein family UPF0029
BB165_RS01915	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BB165_RS01920	COG1040	competence protein
BB165_RS01955	COG0527	aspartate kinase activity
BB165_RS01960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BB165_RS01965	COG1024	Enoyl-CoA hydratase
BB165_RS01975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BB165_RS01985	COG2070	2-Nitropropane dioxygenase
BB165_RS01990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BB165_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
BB165_RS02000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BB165_RS02015	COG0439	Biotin carboxylase
BB165_RS02035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BB165_RS02050	COG3716	PTS system mannose fructose sorbose family IID component
BB165_RS02055	COG3715	PTS system
BB165_RS02070	COG0561	phosphatase activity
BB165_RS02085	COG2252	PERMEase
BB165_RS02090	COG0802	atpase or kinase
BB165_RS02100	COG1316	TRANSCRIPTIONal
BB165_RS02110	COG0537	adenosine 5'-monophosphoramidase activity
BB165_RS02125	COG1131	(ABC) transporter
BB165_RS02130	COG4473	ABC transporter
BB165_RS02140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BB165_RS02155	COG0195	Participates in both transcription termination and antitermination
BB165_RS02160	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BB165_RS02170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BB165_RS02175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BB165_RS02200	COG2860	membrane
BB165_RS02210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BB165_RS02210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BB165_RS02215	COG1832	CoA-binding protein
BB165_RS02235	COG5002	protein histidine kinase activity
BB165_RS02255	COG1268	BioY protein
BB165_RS02260	COG1234	tRNA 3'-trailer cleavage
BB165_RS02275	COG0166	Belongs to the GPI family
BB165_RS02280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BB165_RS02285	COG0457	Tetratricopeptide repeat
BB165_RS02285	COG0705	Rhomboid family
BB165_RS02290	COG1744	ABC transporter substrate-binding protein PnrA-like
BB165_RS02295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BB165_RS02300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BB165_RS02305	COG0594	ribonuclease P activity
BB165_RS02310	COG0706	membrane insertase activity
BB165_RS02380	COG2137	regulation of response to DNA damage stimulus
BB165_RS02385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BB165_RS02395	COG2153	protein acetylation
BB165_RS02405	COG1216	Glycosyl transferase, family 2
BB165_RS02405	COG1442	glycosyl transferase family 8
BB165_RS02445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BB165_RS02455	COG0789	Transcriptional regulator
BB165_RS02490	COG3328	transposase activity
BB165_RS02515	COG1396	sequence-specific DNA binding
BB165_RS02580	COG2226	methyltransferase
BB165_RS02600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BB165_RS02610	COG0525	valine-tRNA ligase activity
BB165_RS02620	COG0673	inositol 2-dehydrogenase activity
BB165_RS02630	COG2315	Protein conserved in bacteria
BB165_RS02635	COG2502	aspartate--ammonia ligase
BB165_RS02645	COG0742	ribosomal rna small subunit methyltransferase
BB165_RS02655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BB165_RS02660	COG3480	Lon protease (S16) C-terminal proteolytic domain
BB165_RS02665	COG0737	Belongs to the 5'-nucleotidase family
BB165_RS02670	COG4470	Protein conserved in bacteria
BB165_RS02675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BB165_RS02685	COG1132	(ABC) transporter
BB165_RS02690	COG1132	(ABC) transporter
BB165_RS02695	COG0512	Glutamine amidotransferase of anthranilate synthase
BB165_RS02700	COG1268	BioY protein
BB165_RS02705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BB165_RS02725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BB165_RS02740	COG1940	carbohydrate kinase activity
BB165_RS02745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BB165_RS02750	COG1217	gtp-binding protein TYPA
BB165_RS02760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BB165_RS02785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BB165_RS02795	COG0762	integral membrane protein
BB165_RS02800	COG2302	S4 RNA-binding domain
BB165_RS02805	COG3599	regulation of cell shape
BB165_RS02810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BB165_RS02820	COG0494	nUDIX hydrolase
BB165_RS02825	COG0542	response to heat
BB165_RS02830	COG4703	Protein of unknown function (DUF1797)
BB165_RS02835	COG0765	amino acid transport
BB165_RS02840	COG1126	abc transporter atp-binding protein
BB165_RS02845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BB165_RS02855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BB165_RS02860	COG1570	exodeoxyribonuclease VII activity
BB165_RS02865	COG1722	exodeoxyribonuclease VII activity
BB165_RS02875	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BB165_RS02880	COG1438	arginine binding
BB165_RS02885	COG0497	DNA recombination
BB165_RS02890	COG1307	EDD domain protein, DegV family
BB165_RS02895	COG2755	lipolytic protein G-D-S-L family
BB165_RS02940	COG1078	dGTPase activity
BB165_RS02965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BB165_RS02975	COG2884	Cell division ATP-binding protein ftsE
BB165_RS02980	COG2177	Part of the ABC transporter FtsEX involved in
BB165_RS03000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BB165_RS03000	COG1199	ATP-dependent helicase activity
BB165_RS03005	COG0436	Aminotransferase
BB165_RS03010	COG0017	Asparaginyl-tRNA synthetase
BB165_RS03030	COG1660	Displays ATPase and GTPase activities
BB165_RS03055	COG0254	rRNA binding
BB165_RS03060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BB165_RS03065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BB165_RS03070	COG0716	FMN binding
BB165_RS03075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BB165_RS03075	COG1605	Chorismate mutase
BB165_RS03080	COG0038	chloride channel
BB165_RS03085	COG0335	large ribosomal subunit rRNA binding
BB165_RS03125	COG1136	(ABC) transporter
BB165_RS03140	COG5002	protein histidine kinase activity
BB165_RS03160	COG0772	Belongs to the SEDS family
BB165_RS03180	COG0560	Phosphoserine phosphatase
BB165_RS03195	COG0148	phosphopyruvate hydratase activity
BB165_RS03215	COG1316	TRANSCRIPTIONal
BB165_RS03230	COG3700	Belongs to the class B bacterial acid phosphatase family
BB165_RS03330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BB165_RS03335	COG4555	ABC transporter
BB165_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
BB165_RS03365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BB165_RS03370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BB165_RS03390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BB165_RS03395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BB165_RS03425	COG1136	(ABC) transporter
BB165_RS03440	COG0586	Pfam SNARE associated Golgi protein
BB165_RS03445	COG4619	ABC transporter
BB165_RS03450	COG0390	transport system, permease component
BB165_RS03460	COG0583	DNA-binding transcription factor activity
BB165_RS03470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BB165_RS03475	COG2211	Major facilitator Superfamily
BB165_RS03485	COG3250	beta-galactosidase activity
BB165_RS03490	COG2186	Transcriptional regulator
BB165_RS03495	COG0800	Aldolase
BB165_RS03500	COG1904	glucuronate isomerase
BB165_RS03520	COG1609	Transcriptional regulator
BB165_RS03535	COG0438	transferase activity, transferring glycosyl groups
BB165_RS03540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BB165_RS03560	COG0765	amino acid transport
BB165_RS03565	COG0765	amino acid transport
BB165_RS03570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BB165_RS03575	COG1126	abc transporter atp-binding protein
BB165_RS03580	COG0745	RESPONSE REGULATOR receiver
BB165_RS03585	COG5002	protein histidine kinase activity
BB165_RS03590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BB165_RS03595	COG2832	Protein of unknown function (DUF454)
BB165_RS03605	COG1196	nuclear chromosome segregation
BB165_RS03610	COG0561	phosphatase activity
BB165_RS03615	COG0561	phosphatase activity
BB165_RS03620	COG0552	protein localization to endoplasmic reticulum
BB165_RS03625	COG3689	TIGRFAM TIGR03943 family protein
BB165_RS03630	COG0701	Predicted permease
BB165_RS03645	COG2183	response to ionizing radiation
BB165_RS03650	COG3091	SprT-like family
BB165_RS03655	COG1983	PspC domain protein
BB165_RS03695	COG0826	peptidase U32
BB165_RS03700	COG4443	Transcriptional Coactivator p15 (PC4)
BB165_RS03710	COG1914	H( )-stimulated, divalent metal cation uptake system
BB165_RS03725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BB165_RS03725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BB165_RS03750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BB165_RS03775	COG1164	Oligoendopeptidase f
BB165_RS03785	COG0772	Belongs to the SEDS family
BB165_RS03805	COG0768	penicillin binding
BB165_RS03820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BB165_RS03825	COG2223	nitrite transmembrane transporter activity
BB165_RS03850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BB165_RS03855	COG2011	ABC-type metal ion transport system permease component
BB165_RS03865	COG0513	Belongs to the DEAD box helicase family
BB165_RS03875	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BB165_RS03880	COG0204	Acyl-transferase
BB165_RS03885	COG1596	polysaccharide export
BB165_RS03885	COG1555	photosystem II stabilization
BB165_RS03890	COG0658	competence protein
BB165_RS03890	COG2333	competence protein COMEC
BB165_RS03895	COG0561	phosphatase activity
BB165_RS03900	COG1609	Transcriptional regulator
BB165_RS03905	COG0657	acetylesterase activity
BB165_RS03910	COG2226	methyltransferase
BB165_RS03920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BB165_RS03925	COG3711	transcriptional antiterminator
BB165_RS03930	COG1263	PTS System
BB165_RS03930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BB165_RS03930	COG2190	(PTS) system
BB165_RS03940	COG3835	regulator
BB165_RS03945	COG1929	Belongs to the glycerate kinase type-1 family
BB165_RS03950	COG2610	gluconate transmembrane transporter activity
BB165_RS03960	COG1846	Transcriptional regulator
BB165_RS03965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BB165_RS03975	COG0363	glucosamine-6-phosphate deaminase activity
BB165_RS03980	COG0435	Glutathione S-transferase
BB165_RS03985	COG1187	pseudouridine synthase activity
BB165_RS04005	COG1164	Oligoendopeptidase f
BB165_RS04010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BB165_RS04015	COG4122	O-methyltransferase activity
BB165_RS04020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BB165_RS04025	COG4894	glucomannan catabolic process
BB165_RS04030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BB165_RS04040	COG1442	glycosyl transferase family 8
BB165_RS04050	COG1476	TRANSCRIPTIONal
BB165_RS04065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BB165_RS04070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BB165_RS04075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BB165_RS04090	COG1012	belongs to the aldehyde dehydrogenase family
BB165_RS04095	COG0726	polysaccharide deacetylase
BB165_RS04100	COG0513	Belongs to the DEAD box helicase family
BB165_RS04105	COG0572	uridine kinase
BB165_RS04110	COG1956	GAF domain-containing protein
BB165_RS04115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BB165_RS04125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BB165_RS04125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BB165_RS04130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BB165_RS04155	COG4721	ABC-type cobalt transport system, permease component
BB165_RS04160	COG1122	ATPase activity
BB165_RS04180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BB165_RS04185	COG0352	thiamine-phosphate diphosphorylase activity
BB165_RS04190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BB165_RS04200	COG4109	DRTGG domain
BB165_RS04205	COG0024	Methionine aminopeptidase
BB165_RS04215	COG2246	polysaccharide biosynthetic process
BB165_RS04220	COG4708	membrane
BB165_RS04225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BB165_RS04230	COG1597	lipid kinase activity
BB165_RS04235	COG1523	belongs to the glycosyl hydrolase 13 family
BB165_RS04240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BB165_RS04245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BB165_RS04250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BB165_RS04255	COG0297	glycogen (starch) synthase activity
BB165_RS04265	COG0356	it plays a direct role in the translocation of protons across the membrane
BB165_RS04280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BB165_RS04285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BB165_RS04290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BB165_RS04295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BB165_RS04305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BB165_RS04320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BB165_RS04330	COG0072	phenylalanine-tRNA ligase activity
BB165_RS04330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB165_RS04335	COG2321	neutral zinc metallopeptidase
BB165_RS04340	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BB165_RS04345	COG1074	ATP-dependent DNA helicase activity
BB165_RS04355	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BB165_RS04360	COG0488	(ABC) transporter
BB165_RS04365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BB165_RS04370	COG0508	dehydrogenase complex catalyzes the overall conversion of
BB165_RS04370	COG0022	dehydrogenase e1 component
BB165_RS04375	COG0508	dehydrogenase complex catalyzes the overall conversion of
BB165_RS04385	COG0095	Lipoate-protein ligase
BB165_RS04390	COG3442	glutamine amidotransferase
BB165_RS04395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BB165_RS04400	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BB165_RS04425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BB165_RS04435	COG0647	UMP catabolic process
BB165_RS04445	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
BB165_RS04450	COG1518	maintenance of DNA repeat elements
BB165_RS04455	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BB165_RS04480	COG0481	GTPase activity
BB165_RS04490	COG1418	mRNA catabolic process
BB165_RS04495	COG0456	acetyltransferase
BB165_RS04505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BB165_RS04535	COG1131	(ABC) transporter
BB165_RS04540	COG1725	Transcriptional regulator
BB165_RS04550	COG0205	6-phosphofructokinase activity
BB165_RS04555	COG0469	pyruvate kinase activity
BB165_RS04570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BB165_RS04575	COG2824	Alkylphosphonate utilization operon protein PhnA
BB165_RS04580	COG0765	amino acid transport
BB165_RS04585	COG1126	abc transporter atp-binding protein
BB165_RS04600	COG1072	(Pantothenic acid kinase))
BB165_RS04605	COG2813	Specifically methylates the guanine in position
BB165_RS04615	COG1744	ABC transporter substrate-binding protein PnrA-like
BB165_RS04620	COG3845	ABC transporter
BB165_RS04625	COG4603	Belongs to the binding-protein-dependent transport system permease family
BB165_RS04630	COG1079	Belongs to the binding-protein-dependent transport system permease family
BB165_RS04650	COG3764	Sortase (surface protein transpeptidase)
BB165_RS04655	COG0346	lactoylglutathione lyase activity
BB165_RS04685	COG1674	ftsk spoiiie
BB165_RS04690	COG2946	Replication initiation factor
BB165_RS04740	COG0741	lytic transglycosylase activity
BB165_RS04740	COG0791	NLP P60 protein
BB165_RS04790	COG0582	viral genome integration into host DNA
BB165_RS04800	COG2188	Transcriptional regulator
BB165_RS04805	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BB165_RS04815	COG1464	Belongs to the NlpA lipoprotein family
BB165_RS04830	COG1136	(ABC) transporter
BB165_RS04840	COG0745	RESPONSE REGULATOR receiver
BB165_RS04845	COG5002	protein histidine kinase activity
BB165_RS04850	COG4974	Belongs to the 'phage' integrase family
BB165_RS04875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BB165_RS04880	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BB165_RS04885	COG5002	protein histidine kinase activity
BB165_RS04890	COG0745	RESPONSE REGULATOR receiver
BB165_RS04900	COG0704	Plays a role in the regulation of phosphate uptake
BB165_RS04905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BB165_RS04910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BB165_RS04915	COG0581	inorganic phosphate transmembrane transporter activity
BB165_RS04920	COG0573	inorganic phosphate transmembrane transporter activity
BB165_RS04930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BB165_RS04930	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BB165_RS04935	COG0483	inositol monophosphate 1-phosphatase activity
BB165_RS04940	COG4476	Belongs to the UPF0223 family
BB165_RS04950	COG0196	riboflavin kinase activity
BB165_RS04955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BB165_RS04985	COG1136	(ABC) transporter
BB165_RS04990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BB165_RS04995	COG0758	DNA mediated transformation
BB165_RS05000	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BB165_RS05005	COG4604	ABC transporter, ATP-binding protein
BB165_RS05010	COG4605	iron ion homeostasis
BB165_RS05015	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BB165_RS05020	COG0110	maltose O-acetyltransferase activity
BB165_RS05030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BB165_RS05035	COG1376	ErfK ybiS ycfS ynhG family protein
BB165_RS05040	COG1966	Carbon starvation protein
BB165_RS05045	COG3279	Response regulator of the LytR AlgR family
BB165_RS05050	COG3275	phosphorelay sensor kinase activity
BB165_RS05190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BB165_RS05195	COG0505	Belongs to the CarA family
BB165_RS05205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BB165_RS05210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BB165_RS05215	COG0284	orotidine-5'-phosphate decarboxylase activity
BB165_RS05225	COG0488	(ABC) transporter
BB165_RS05235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BB165_RS05245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BB165_RS05250	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BB165_RS05285	COG0095	Lipoate-protein ligase
BB165_RS05295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BB165_RS05300	COG4684	Psort location CytoplasmicMembrane, score
BB165_RS05305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BB165_RS05315	COG1132	(ABC) transporter
BB165_RS05335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BB165_RS05345	COG2890	protein-(glutamine-N5) methyltransferase activity
BB165_RS05350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BB165_RS05360	COG1942	4-Oxalocrotonate Tautomerase
BB165_RS05375	COG3976	FMN-binding domain protein
BB165_RS05375	COG1053	succinate dehydrogenase
BB165_RS05375	COG0431	NADPH-dependent FMN reductase
BB165_RS05385	COG2233	PERMEase
BB165_RS05410	COG3843	relaxase mobilization nuclease domain protein
BB165_RS05465	COG1388	LysM domain
BB165_RS05465	COG3942	CHAP domain
BB165_RS05535	COG3620	sequence-specific DNA binding
BB165_RS05565	COG0516	GMP reductase activity
BB165_RS05570	COG0477	Major facilitator Superfamily
BB165_RS05580	COG3158	transport of potassium into the cell
BB165_RS05585	COG4221	oxidoreductase activity
BB165_RS05590	COG0280	phosphate acetyltransferase
BB165_RS05595	COG0564	pseudouridine synthase activity
BB165_RS05600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BB165_RS05605	COG2357	RelA SpoT domain protein
BB165_RS05620	COG1104	cysteine desulfurase activity
BB165_RS05630	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BB165_RS05635	COG2003	Belongs to the UPF0758 family
BB165_RS05640	COG0628	permease
BB165_RS05645	COG2723	6-phospho-beta-galactosidase activity
BB165_RS05655	COG0561	phosphatase activity
BB165_RS05670	COG0038	chloride channel
BB165_RS05680	COG1177	transmembrane transport
BB165_RS05685	COG1176	ABC-type spermidine putrescine transport system, permease component I
BB165_RS05695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BB165_RS05700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BB165_RS05715	COG0302	gtp cyclohydrolase
BB165_RS05720	COG0285	dihydrofolate synthase activity
BB165_RS05725	COG2962	Rard protein
BB165_RS05740	COG0726	polysaccharide deacetylase
BB165_RS05750	COG1012	belongs to the aldehyde dehydrogenase family
BB165_RS05780	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BB165_RS05825	COG2261	transglycosylase associated protein
BB165_RS05850	COG1115	amino acid carrier protein
BB165_RS05855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BB165_RS05865	COG1346	cytolysis
BB165_RS05900	COG4974	Belongs to the 'phage' integrase family
BB165_RS05910	COG0539	negative regulation of cytoplasmic translation
BB165_RS05930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BB165_RS05940	COG0187	DNA topoisomerase II activity
BB165_RS05945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BB165_RS05950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BB165_RS05960	COG1083	cytidylyl-transferase
BB165_RS05960	COG2755	lipolytic protein G-D-S-L family
BB165_RS05975	COG2089	acid synthase
BB165_RS05990	COG1442	glycosyl transferase family 8
BB165_RS05990	COG1216	Glycosyl transferase, family 2
BB165_RS05995	COG1442	glycosyl transferase family 8
BB165_RS05995	COG1216	Glycosyl transferase, family 2
BB165_RS06010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BB165_RS06015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BB165_RS06020	COG0489	protein tyrosine kinase activity
BB165_RS06030	COG4464	protein tyrosine phosphatase activity
BB165_RS06035	COG1316	TRANSCRIPTIONal
BB165_RS06060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BB165_RS06075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BB165_RS06095	COG3842	ATPase activity
BB165_RS06110	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BB165_RS06115	COG3527	Alpha-acetolactate decarboxylase
BB165_RS06120	COG0028	Belongs to the TPP enzyme family
BB165_RS06125	COG0457	Tetratricopeptide repeat
BB165_RS06130	COG0628	permease
BB165_RS06140	COG1051	belongs to the nudix hydrolase family
BB165_RS06145	COG5492	domain, Protein
BB165_RS06150	COG1088	dTDP-glucose 4,6-dehydratase activity
BB165_RS06160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BB165_RS06165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BB165_RS06175	COG2384	SAM-dependent methyltransferase
BB165_RS06200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BB165_RS06200	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BB165_RS06205	COG0300	oxidoreductase activity
BB165_RS06220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BB165_RS06225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BB165_RS06250	COG1573	uracil-dna glycosylase
BB165_RS06255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BB165_RS06265	COG0584	glycerophosphoryl diester phosphodiesterase
BB165_RS06270	COG0322	excinuclease ABC activity
BB165_RS06280	COG0534	Mate efflux family protein
BB165_RS06320	COG0803	Belongs to the bacterial solute-binding protein 9 family
BB165_RS06340	COG2176	DNA-directed DNA polymerase activity
BB165_RS06350	COG4974	Belongs to the 'phage' integrase family
BB165_RS06380	COG1674	ftsk spoiiie
BB165_RS06405	COG4974	Belongs to the 'phage' integrase family
BB165_RS06415	COG1396	sequence-specific DNA binding
BB165_RS06425	COG2723	6-phospho-beta-galactosidase activity
BB165_RS06440	COG3711	transcriptional antiterminator
BB165_RS06445	COG3684	Belongs to the aldolase LacD family
BB165_RS06450	COG1105	Belongs to the carbohydrate kinase PfkB family
BB165_RS06455	COG0698	ribose 5-phosphate isomerase
BB165_RS06460	COG0698	ribose 5-phosphate isomerase
BB165_RS06465	COG1349	DNA-binding transcription factor activity
BB165_RS06470	COG3843	relaxase mobilization nuclease domain protein
BB165_RS06500	COG0542	response to heat
BB165_RS06505	COG1396	sequence-specific DNA binding
BB165_RS06635	COG0270	DNA (cytosine-5-)-methyltransferase activity
BB165_RS06665	COG2040	homocysteine
BB165_RS06670	COG0833	amino acid
BB165_RS06710	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BB165_RS06720	COG3425	synthase
BB165_RS06735	COG1272	protein, Hemolysin III
BB165_RS06780	COG0745	RESPONSE REGULATOR receiver
BB165_RS06785	COG2357	RelA SpoT domain protein
BB165_RS06790	COG1132	(ABC) transporter
BB165_RS06805	COG0737	Belongs to the 5'-nucleotidase family
BB165_RS06810	COG0242	peptide deformylase activity
BB165_RS06815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BB165_RS06825	COG1132	(ABC) transporter
BB165_RS06840	COG0488	(ABC) transporter
BB165_RS06870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BB165_RS06870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BB165_RS06870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BB165_RS06875	COG1105	Belongs to the carbohydrate kinase PfkB family
BB165_RS06880	COG1349	DNA-binding transcription factor activity
BB165_RS06885	COG1705	Flagellar rod assembly protein muramidase FlgJ
BB165_RS06885	COG1388	LysM domain
BB165_RS06935	COG1837	Belongs to the UPF0109 family
BB165_RS06940	COG0228	four-way junction DNA binding
BB165_RS06945	COG0577	efflux transmembrane transporter activity
BB165_RS06950	COG1136	(ABC) transporter
BB165_RS06955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BB165_RS06965	COG0505	Belongs to the CarA family
BB165_RS06975	COG0564	pseudouridine synthase activity
BB165_RS06985	COG0583	DNA-binding transcription factor activity
BB165_RS06990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BB165_RS07010	COG0301	tRNA thio-modification
BB165_RS07015	COG1104	cysteine desulfurase activity
BB165_RS07025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BB165_RS07030	COG3679	Belongs to the UPF0342 family
BB165_RS07035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BB165_RS07040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BB165_RS07050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BB165_RS07055	COG1368	sulfuric ester hydrolase activity
BB165_RS07060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BB165_RS07070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BB165_RS07075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BB165_RS07095	COG2195	Cleaves the N-terminal amino acid of tripeptides
BB165_RS07100	COG2244	polysaccharide biosynthetic process
BB165_RS07105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BB165_RS07110	COG1120	ATPase activity
BB165_RS07115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BB165_RS07120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BB165_RS07125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BB165_RS07135	COG1227	inorganic diphosphatase activity
BB165_RS07140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BB165_RS07145	COG1253	flavin adenine dinucleotide binding
BB165_RS07150	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BB165_RS07155	COG1242	4 iron, 4 sulfur cluster binding
BB165_RS07160	COG0671	phosphoesterase, PA-phosphatase related
BB165_RS07165	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BB165_RS07205	COG0297	glycogen (starch) synthase activity
BB165_RS07245	COG3475	LICD family
BB165_RS07260	COG0463	Glycosyl transferase, family 2
BB165_RS07265	COG1215	transferase activity, transferring glycosyl groups
BB165_RS07275	COG1091	dTDP-4-dehydrorhamnose reductase activity
BB165_RS07280	COG2151	metal-sulfur cluster biosynthetic enzyme
BB165_RS07285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BB165_RS07290	COG0358	DNA primase activity
BB165_RS07295	COG1970	mechanosensitive ion channel activity
BB165_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BB165_RS07315	COG0004	ammonium transporteR
BB165_RS07325	COG1054	Belongs to the UPF0176 family
BB165_RS07335	COG2271	Major facilitator Superfamily
BB165_RS07340	COG0058	SHG alpha-glucan phosphorylase activity
BB165_RS07345	COG1640	4-alpha-glucanotransferase
BB165_RS07350	COG1609	Transcriptional regulator
BB165_RS07360	COG1175	transmembrane transport
BB165_RS07365	COG3833	ABC-type maltose transport systems, permease component
BB165_RS07370	COG3104	oligopeptide transport
BB165_RS07390	COG0438	transferase activity, transferring glycosyl groups
BB165_RS07395	COG0653	protein targeting
BB165_RS07415	COG0201	protein transport
BB165_RS07420	COG1442	glycosyl transferase family 8
BB165_RS07425	COG1216	Glycosyl transferase, family 2
BB165_RS07425	COG1442	glycosyl transferase family 8
BB165_RS07430	COG1442	glycosyl transferase family 8
BB165_RS07435	COG1216	Glycosyl transferase, family 2
BB165_RS07435	COG1442	glycosyl transferase family 8
BB165_RS07440	COG1442	glycosyl transferase family 8
BB165_RS07470	COG0765	amino acid transport
BB165_RS07475	COG1126	abc transporter atp-binding protein
BB165_RS07500	COG2309	aminopeptidase activity
BB165_RS07510	COG0154	amidase activity
BB165_RS07515	COG1187	pseudouridine synthase activity
BB165_RS07520	COG0656	L-ascorbic acid biosynthetic process
BB165_RS07525	COG0778	Nitroreductase
BB165_RS07530	COG0346	lactoylglutathione lyase activity
BB165_RS07535	COG0463	Glycosyl transferase, family 2
BB165_RS07540	COG1113	amino acid transport
BB165_RS07545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BB165_RS07550	COG0557	exoribonuclease II activity
BB165_RS07565	COG2814	Major facilitator Superfamily
BB165_RS07575	COG1131	(ABC) transporter
BB165_RS07580	COG0237	dephospho-CoA kinase activity
BB165_RS07585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BB165_RS07590	COG1396	sequence-specific DNA binding
BB165_RS07645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BB165_RS07650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BB165_RS07675	COG1702	phosphate starvation-inducible protein PhoH
BB165_RS07690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BB165_RS07700	COG0233	cytoplasmic translational termination
BB165_RS07705	COG0528	UMP kinase activity
BB165_RS07715	COG0444	Belongs to the ABC transporter superfamily
BB165_RS07720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BB165_RS07725	COG0601	transmembrane transport
BB165_RS07730	COG0747	negative chemotaxis
BB165_RS07735	COG0081	regulation of translation
BB165_RS07740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BB165_RS07750	COG1473	amidohydrolase
BB165_RS07755	COG0583	DNA-binding transcription factor activity
BB165_RS07765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BB165_RS07770	COG1674	ftsk spoiiie
BB165_RS07775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BB165_RS07800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BB165_RS07815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BB165_RS07830	COG0673	inositol 2-dehydrogenase activity
BB165_RS07845	COG1028	Short-chain dehydrogenase reductase Sdr
BB165_RS07895	COG1114	Component of the transport system for branched-chain amino acids
BB165_RS07900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB165_RS07900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB165_RS07920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BB165_RS07930	COG0708	Exodeoxyribonuclease III
BB165_RS07935	COG1393	Belongs to the ArsC family
BB165_RS07940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BB165_RS07945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BB165_RS07955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BB165_RS07985	COG0470	DNA polymerase III
BB165_RS07995	COG0517	IMP dehydrogenase activity
BB165_RS08035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BB165_RS08040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BB165_RS08050	COG0531	amino acid
BB165_RS08055	COG0569	domain protein
BB165_RS08065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BB165_RS08070	COG1187	pseudouridine synthase activity
BB165_RS08080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BB165_RS08085	COG0582	viral genome integration into host DNA
BB165_RS08105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BB165_RS08120	COG1827	regulation of RNA biosynthetic process
BB165_RS08135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BB165_RS08140	COG1254	Belongs to the acylphosphatase family
BB165_RS08145	COG0706	membrane insertase activity
BB165_RS08150	COG0765	amino acid transport
BB165_RS08155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BB165_RS08170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BB165_RS08180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BB165_RS08205	COG1484	DNA-dependent DNA replication
BB165_RS08220	COG5002	protein histidine kinase activity
BB165_RS08225	COG0745	RESPONSE REGULATOR receiver
BB165_RS08235	COG0501	Belongs to the peptidase M48B family
BB165_RS08240	COG1704	LemA family
BB165_RS08245	COG0357	Ribosomal RNA small subunit methyltransferase G
BB165_RS08250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BB165_RS08255	COG0569	domain protein
BB165_RS08265	COG1122	ATPase activity
BB165_RS08275	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BB165_RS08280	COG1114	Component of the transport system for branched-chain amino acids
BB165_RS08285	COG1063	alcohol dehydrogenase
BB165_RS08295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BB165_RS08310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BB165_RS08325	COG0217	transcriptional regulatory protein
BB165_RS08330	COG2376	Dihydroxyacetone kinase
BB165_RS08335	COG1309	transcriptional regulator
BB165_RS08345	COG2376	Dihydroxyacetone kinase
BB165_RS08350	COG1461	Dihydroxyacetone kinase
BB165_RS08355	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BB165_RS08360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BB165_RS08375	COG1323	Belongs to the UPF0348 family
BB165_RS08385	COG2226	methyltransferase
BB165_RS08390	COG0799	negative regulation of ribosome biogenesis
BB165_RS08400	COG1713	HD superfamily hydrolase involved in NAD metabolism
BB165_RS08405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BB165_RS08410	COG1534	Rna-binding protein
BB165_RS08415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BB165_RS08420	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BB165_RS08430	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BB165_RS08435	COG0154	amidase activity
BB165_RS08440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BB165_RS08445	COG0574	Belongs to the PEP-utilizing enzyme family
BB165_RS08445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BB165_RS08450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BB165_RS08455	COG0517	IMP dehydrogenase activity
BB165_RS08465	COG1335	isochorismatase
BB165_RS08470	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BB165_RS08475	COG0436	Aminotransferase
BB165_RS08480	COG0589	response to stress
BB165_RS08485	COG0561	phosphatase activity
BB165_RS08490	COG0252	asparaginase activity
BB165_RS08500	COG4989	oxidoreductase activity
BB165_RS08505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BB165_RS08510	COG1705	Flagellar rod assembly protein muramidase FlgJ
BB165_RS08510	COG3942	CHAP domain
BB165_RS08520	COG0736	holo-[acyl-carrier-protein] synthase activity
BB165_RS08525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BB165_RS08535	COG1482	cell wall glycoprotein biosynthetic process
BB165_RS08540	COG1940	carbohydrate kinase activity
BB165_RS08545	COG2190	(PTS) system
BB165_RS08545	COG1263	PTS System
BB165_RS08545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BB165_RS08550	COG1621	beta-fructofuranosidase activity
BB165_RS08555	COG1609	Transcriptional regulator
BB165_RS08560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BB165_RS08570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BB165_RS08585	COG1132	(ABC) transporter
BB165_RS08595	COG1129	ABC transporter
BB165_RS08620	COG1021	2,3-dihydroxybenzoate-AMP ligase
BB165_RS08630	COG2131	deaminase
BB165_RS08635	COG0006	proline dipeptidase activity
BB165_RS08645	COG2814	Major facilitator Superfamily
BB165_RS08675	COG0629	single-stranded DNA binding
BB165_RS08680	COG0360	Binds together with S18 to 16S ribosomal RNA
BB165_RS08685	COG1194	a g-specific adenine glycosylase
BB165_RS08695	COG3118	belongs to the thioredoxin family
BB165_RS08705	COG1193	negative regulation of DNA recombination
BB165_RS08720	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BB165_RS08725	COG0681	Belongs to the peptidase S26 family
BB165_RS08730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BB165_RS08745	COG1882	Formate acetyltransferase
BB165_RS08750	COG3576	pyridoxamine 5-phosphate
BB165_RS08755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BB165_RS08770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BB165_RS08780	COG2814	Major facilitator Superfamily
BB165_RS08785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BB165_RS08790	COG2936	dipeptidyl-peptidase activity
BB165_RS08800	COG0142	geranyltranstransferase activity
BB165_RS08805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BB165_RS08810	COG4988	ABC transporter
BB165_RS08815	COG1294	oxidase, subunit
BB165_RS08820	COG1271	oxidase subunit
BB165_RS08825	COG1252	NADH dehydrogenase
BB165_RS08845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BB165_RS08850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BB165_RS08855	COG0789	Transcriptional regulator
BB165_RS08870	COG2081	HI0933 family
BB165_RS08895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BB165_RS08900	COG0456	acetyltransferase
BB165_RS08905	COG1214	PFAM Peptidase M22, glycoprotease
BB165_RS08920	COG3942	CHAP domain
BB165_RS08925	COG0174	glutamine synthetase
BB165_RS08930	COG0789	Transcriptional regulator
BB165_RS08940	COG0126	phosphoglycerate kinase activity
BB165_RS08945	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BB165_RS08955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BB165_RS08970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BB165_RS08995	COG1162	GTPase activity
BB165_RS09005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BB165_RS09020	COG0084	hydrolase, TatD family'
BB165_RS09050	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BB165_RS09055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BB165_RS09060	COG1696	Membrane protein involved in D-alanine export
BB165_RS09065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BB165_RS09075	COG5002	protein histidine kinase activity
BB165_RS09080	COG0745	RESPONSE REGULATOR receiver
BB165_RS09090	COG3314	Sporulation integral membrane protein YlbJ
BB165_RS09100	COG3448	diguanylate cyclase activity
BB165_RS09100	COG4175	Glycine betaine
BB165_RS09110	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BB165_RS09130	COG1070	Carbohydrate kinase
BB165_RS09140	COG3775	system Galactitol-specific IIC component
BB165_RS09145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BB165_RS09155	COG1609	Transcriptional regulator
BB165_RS09205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BB165_RS09235	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BB165_RS09240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BB165_RS09245	COG1428	Deoxynucleoside kinase
BB165_RS09255	COG0542	response to heat
BB165_RS09260	COG4463	regulation of RNA biosynthetic process
BB165_RS09270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BB165_RS09280	COG0450	alkyl hydroperoxide reductase
BB165_RS09295	COG0025	NhaP-type Na H and K H
BB165_RS09305	COG1619	proteins homologs of microcin C7 resistance protein MccF
BB165_RS09310	COG3590	peptidase
BB165_RS09340	COG1609	Transcriptional regulator
BB165_RS09350	COG3716	PTS system mannose fructose sorbose family IID component
BB165_RS09355	COG3715	PTS system
BB165_RS09360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BB165_RS09365	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BB165_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
BB165_RS09410	COG2176	DNA-directed DNA polymerase activity
BB165_RS09415	COG1388	LysM domain
BB165_RS09415	COG1705	Flagellar rod assembly protein muramidase FlgJ
BB165_RS09420	COG0442	prolyl-tRNA aminoacylation
BB165_RS09430	COG4589	Belongs to the CDS family
BB165_RS09435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BB165_RS09440	COG1862	Preprotein translocase
BB165_RS09460	COG3493	citrate carrier protein
BB165_RS09465	COG3290	protein histidine kinase activity
BB165_RS09470	COG4565	transcriptional regulatory protein
BB165_RS09475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BB165_RS09485	COG3842	ATPase activity
BB165_RS09560	COG1490	D-aminoacyl-tRNA deacylase activity
BB165_RS09570	COG0737	Belongs to the 5'-nucleotidase family
BB165_RS09580	COG1363	Peptidase, m42
BB165_RS09595	COG4753	response regulator
BB165_RS09595	COG2207	Transcriptional regulator
BB165_RS09600	COG2972	Histidine kinase
BB165_RS09605	COG3716	PTS system mannose fructose sorbose family IID component
BB165_RS09610	COG3715	PTS system
BB165_RS09640	COG1131	(ABC) transporter
BB165_RS09650	COG3279	Response regulator of the LytR AlgR family
BB165_RS09660	COG1263	PTS System
BB165_RS09660	COG2190	(PTS) system
BB165_RS09660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BB165_RS09665	COG5002	protein histidine kinase activity
BB165_RS09670	COG0745	RESPONSE REGULATOR receiver
BB165_RS09680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BB165_RS09685	COG0581	inorganic phosphate transmembrane transporter activity
BB165_RS09690	COG0573	inorganic phosphate transmembrane transporter activity
BB165_RS09705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BB165_RS09720	COG0789	Transcriptional regulator
BB165_RS09745	COG0456	acetyltransferase
BB165_RS09750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BB165_RS09795	COG1131	(ABC) transporter
BB165_RS09835	COG1131	(ABC) transporter
BB165_RS09845	COG1396	sequence-specific DNA binding
BB165_RS09855	COG1694	Mazg nucleotide pyrophosphohydrolase
BB165_RS09890	COG0371	Dehydrogenase
BB165_RS09900	COG0646	methionine synthase
BB165_RS09900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BB165_RS09905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BB165_RS09915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BB165_RS09925	COG0745	RESPONSE REGULATOR receiver
BB165_RS09930	COG2205	protein histidine kinase activity
BB165_RS09930	COG2770	Histidine kinase
BB165_RS09940	COG0495	leucyl-tRNA aminoacylation
BB165_RS09945	COG2814	Major facilitator Superfamily
BB165_RS09950	COG4667	esterase of the alpha-beta hydrolase superfamily
BB165_RS09955	COG1442	glycosyl transferase family 8
BB165_RS09960	COG1442	glycosyl transferase family 8
BB165_RS09985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BB165_RS09990	COG0564	pseudouridine synthase activity
BB165_RS10010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BB165_RS10015	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BB165_RS10035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BB165_RS10040	COG1116	anion transmembrane transporter activity
BB165_RS10040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BB165_RS10050	COG0561	phosphatase activity
BB165_RS10055	COG2514	catechol 2,3-dioxygenase activity
BB165_RS10060	COG3022	response to hydroperoxide
BB165_RS10065	COG0602	queuosine metabolic process
BB165_RS10085	COG1328	CTP reductase activity
BB165_RS10105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BB165_RS10115	COG1393	Belongs to the ArsC family
BB165_RS10120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BB165_RS10125	COG1546	Belongs to the CinA family
BB165_RS10125	COG1058	Belongs to the CinA family
BB165_RS10130	COG2818	Glycosylase
BB165_RS10145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BB165_RS10170	COG0018	arginyl-trna synthetase
BB165_RS10180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BB165_RS10185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BB165_RS10190	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BB165_RS10195	COG0124	histidyl-tRNA synthetase
BB165_RS10205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BB165_RS10260	COG4974	Belongs to the 'phage' integrase family
BB165_RS10295	COG0745	RESPONSE REGULATOR receiver
BB165_RS10300	COG5002	protein histidine kinase activity
BB165_RS10305	COG1288	antiporter activity
BB165_RS10315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BB165_RS10320	COG3852	Histidine kinase
BB165_RS10325	COG0784	Response regulator, receiver
BB165_RS10330	COG0517	IMP dehydrogenase activity
BB165_RS10330	COG1125	glycine betaine transport
BB165_RS10335	COG1174	glycine betaine transport
BB165_RS10340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BB165_RS10340	COG0392	lysyltransferase activity
BB165_RS10350	COG3759	membrane
BB165_RS10380	COG0305	Participates in initiation and elongation during chromosome replication
BB165_RS10395	COG0445	tRNA wobble uridine modification
BB165_RS10400	COG2095	MarC family integral membrane protein
BB165_RS10405	COG0482	sulfurtransferase activity
BB165_RS10410	COG1760	l-serine dehydratase
BB165_RS10415	COG1760	l-serine dehydratase
BB165_RS10420	COG0741	lytic transglycosylase activity
BB165_RS10445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BB165_RS10450	COG0612	Peptidase, M16
BB165_RS10455	COG0612	Peptidase, M16
BB165_RS10460	COG2501	S4 domain
BB165_RS10480	COG0517	IMP dehydrogenase activity
BB165_RS10480	COG0516	GMP reductase activity
BB165_RS10490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BB165_RS10505	COG0454	-acetyltransferase
BB165_RS10510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BB165_RS10535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BB165_RS10540	COG0488	(ABC) transporter
BB165_RS10545	COG4485	Bacterial membrane protein, YfhO
BB165_RS10565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BB165_RS10570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BB165_RS10575	COG1475	DNA binding
BB165_RS10585	COG0592	DNA-directed DNA polymerase activity
BB165_RS10590	COG1597	lipid kinase activity
BB165_RS10605	COG0012	GTP binding
BB165_RS10615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BB165_RS10625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BB165_RS10655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins