locus-tag	class	description
C2E46_RS00010	COG0592	DNA-directed DNA polymerase activity
C2E46_RS00015	COG1597	lipid kinase activity
C2E46_RS00030	COG0012	GTP binding
C2E46_RS00040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2E46_RS00050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2E46_RS00070	COG0037	tRNA processing
C2E46_RS00080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2E46_RS00260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2E46_RS00265	COG0436	Aminotransferase
C2E46_RS00280	COG0416	fatty acid biosynthetic process
C2E46_RS00285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2E46_RS00290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2E46_RS00295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2E46_RS00305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2E46_RS00310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2E46_RS00320	COG0138	bifunctional purine biosynthesis protein purh
C2E46_RS00345	COG1175	transmembrane transport
C2E46_RS00350	COG0395	ABC-type sugar transport system, permease component
C2E46_RS00365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2E46_RS00375	COG3458	cephalosporin-C deacetylase activity
C2E46_RS00390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2E46_RS00420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2E46_RS00435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2E46_RS00445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2E46_RS00445	COG2755	lipolytic protein G-D-S-L family
C2E46_RS00450	COG1012	belongs to the aldehyde dehydrogenase family
C2E46_RS00450	COG1454	alcohol dehydrogenase
C2E46_RS00455	COG1064	alcohol dehydrogenase
C2E46_RS00465	COG0534	Mate efflux family protein
C2E46_RS00575	COG0201	protein transport
C2E46_RS00580	COG0563	adenylate kinase activity
C2E46_RS00590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2E46_RS00605	COG0202	RNA polymerase activity
C2E46_RS00695	COG3328	transposase activity
C2E46_RS00730	COG3344	reverse transcriptase
C2E46_RS00750	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E46_RS00760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2E46_RS00775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2E46_RS00780	COG0101	tRNA pseudouridine synthase activity
C2E46_RS00785	COG0351	phosphomethylpyrimidine kinase
C2E46_RS00790	COG4720	Psort location CytoplasmicMembrane, score
C2E46_RS00795	COG4475	Protein of unknown function (DUF436)
C2E46_RS00800	COG0668	transmembrane transport
C2E46_RS00830	COG0756	dUTP diphosphatase activity
C2E46_RS00845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2E46_RS00850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2E46_RS00855	COG1879	ABC-type sugar transport system periplasmic component
C2E46_RS00860	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2E46_RS00875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2E46_RS00880	COG1609	Transcriptional regulator
C2E46_RS00890	COG1136	(ABC) transporter
C2E46_RS00895	COG0745	RESPONSE REGULATOR receiver
C2E46_RS00900	COG5002	protein histidine kinase activity
C2E46_RS00910	COG0165	Argininosuccinate lyase
C2E46_RS00915	COG0191	fructose-bisphosphate aldolase activity
C2E46_RS00935	COG1461	Dihydroxyacetone kinase
C2E46_RS00955	COG1126	abc transporter atp-binding protein
C2E46_RS00960	COG0765	amino acid transport
C2E46_RS00970	COG1968	undecaprenyl-diphosphatase activity
C2E46_RS00975	COG4862	establishment of competence for transformation
C2E46_RS00980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2E46_RS00990	COG0719	Fe-S assembly protein
C2E46_RS00995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2E46_RS01005	COG0719	Fe-S assembly protein
C2E46_RS01010	COG1686	Belongs to the peptidase S11 family
C2E46_RS01015	COG1686	Belongs to the peptidase S11 family
C2E46_RS01020	COG4166	transmembrane transport
C2E46_RS01025	COG0601	transmembrane transport
C2E46_RS01030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2E46_RS01035	COG0444	Belongs to the ABC transporter superfamily
C2E46_RS01040	COG4608	Belongs to the ABC transporter superfamily
C2E46_RS01080	COG1121	(ABC) transporter
C2E46_RS01085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2E46_RS01100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2E46_RS01105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2E46_RS01105	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2E46_RS01130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2E46_RS01135	COG1459	type II secretion system
C2E46_RS01195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2E46_RS01200	COG1363	Peptidase, m42
C2E46_RS01215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2E46_RS01220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E46_RS01235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2E46_RS01240	COG3275	phosphorelay sensor kinase activity
C2E46_RS01245	COG3279	Response regulator of the LytR AlgR family
C2E46_RS01255	COG1346	cytolysis
C2E46_RS01265	COG0601	transmembrane transport
C2E46_RS01270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2E46_RS01275	COG1122	ATPase activity
C2E46_RS01285	COG1263	PTS System
C2E46_RS01285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E46_RS01290	COG0366	Alpha amylase catalytic
C2E46_RS01295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E46_RS01310	COG3959	Transketolase, thiamine diphosphate binding domain
C2E46_RS01315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2E46_RS01320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2E46_RS01340	COG1045	serine acetyltransferase
C2E46_RS01350	COG0215	cysteine-tRNA ligase activity
C2E46_RS01355	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C2E46_RS01375	COG1476	TRANSCRIPTIONal
C2E46_RS01380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2E46_RS01400	COG3942	CHAP domain
C2E46_RS01400	COG1388	LysM domain
C2E46_RS01415	COG0433	COG0433 Predicted ATPase
C2E46_RS01460	COG1674	ftsk spoiiie
C2E46_RS01480	COG3620	sequence-specific DNA binding
C2E46_RS01515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2E46_RS01540	COG0582	viral genome integration into host DNA
C2E46_RS01580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2E46_RS01585	COG0732	type I restriction modification DNA specificity domain
C2E46_RS01590	COG4974	Belongs to the 'phage' integrase family
C2E46_RS01595	COG0732	type I restriction modification DNA specificity domain
C2E46_RS01610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2E46_RS01630	COG1396	sequence-specific DNA binding
C2E46_RS01635	COG2814	Major facilitator Superfamily
C2E46_RS01645	COG1732	Glycine betaine
C2E46_RS01750	COG1396	sequence-specific DNA binding
C2E46_RS01770	COG1132	(ABC) transporter
C2E46_RS01825	COG1695	Transcriptional regulator
C2E46_RS01840	COG1755	Isoprenylcysteine carboxyl methyltransferase
C2E46_RS01855	COG0751	glycine-tRNA ligase activity
C2E46_RS01860	COG4224	UPF0291 protein
C2E46_RS01880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2E46_RS01885	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2E46_RS01905	COG1131	(ABC) transporter
C2E46_RS01915	COG1263	PTS System
C2E46_RS01915	COG2190	(PTS) system
C2E46_RS01915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E46_RS01925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2E46_RS01930	COG0275	rRNA processing
C2E46_RS01940	COG0768	penicillin binding
C2E46_RS01950	COG0513	Belongs to the DEAD box helicase family
C2E46_RS01965	COG1126	abc transporter atp-binding protein
C2E46_RS01975	COG0492	ferredoxin-NADP+ reductase activity
C2E46_RS01980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2E46_RS01990	COG3579	cysteine-type endopeptidase activity
C2E46_RS01995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2E46_RS02005	COG4474	Belongs to the UPF0398 family
C2E46_RS02020	COG0116	Belongs to the methyltransferase superfamily
C2E46_RS02040	COG1131	(ABC) transporter
C2E46_RS02055	COG2197	response regulator
C2E46_RS02075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2E46_RS02085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2E46_RS02085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2E46_RS02095	COG2815	serine threonine protein kinase
C2E46_RS02095	COG0515	serine threonine protein kinase
C2E46_RS02105	COG4585	Histidine kinase
C2E46_RS02110	COG2197	response regulator
C2E46_RS02120	COG1098	S1 RNA binding domain
C2E46_RS02125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2E46_RS02130	COG1349	DNA-binding transcription factor activity
C2E46_RS02160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E46_RS02185	COG1739	Uncharacterized protein family UPF0029
C2E46_RS02190	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2E46_RS02195	COG1040	competence protein
C2E46_RS02230	COG0527	aspartate kinase activity
C2E46_RS02235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2E46_RS02240	COG1024	Enoyl-CoA hydratase
C2E46_RS02265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2E46_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
C2E46_RS02275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2E46_RS02290	COG0439	Biotin carboxylase
C2E46_RS02335	COG3716	PTS system mannose fructose sorbose family IID component
C2E46_RS02340	COG3715	PTS system
C2E46_RS02350	COG0561	phosphatase activity
C2E46_RS02365	COG2252	PERMEase
C2E46_RS02370	COG0802	atpase or kinase
C2E46_RS02375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2E46_RS02380	COG1316	TRANSCRIPTIONal
C2E46_RS02395	COG0537	adenosine 5'-monophosphoramidase activity
C2E46_RS02410	COG1131	(ABC) transporter
C2E46_RS02415	COG4473	ABC transporter
C2E46_RS02435	COG0779	Required for maturation of 30S ribosomal subunits
C2E46_RS02440	COG0195	Participates in both transcription termination and antitermination
C2E46_RS02445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2E46_RS02485	COG2860	membrane
C2E46_RS02495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E46_RS02495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E46_RS02500	COG1832	CoA-binding protein
C2E46_RS02520	COG5002	protein histidine kinase activity
C2E46_RS02540	COG1268	BioY protein
C2E46_RS02545	COG1234	tRNA 3'-trailer cleavage
C2E46_RS02565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2E46_RS02570	COG0457	Tetratricopeptide repeat
C2E46_RS02570	COG0705	Rhomboid family
C2E46_RS02575	COG1744	ABC transporter substrate-binding protein PnrA-like
C2E46_RS02580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2E46_RS02595	COG0706	membrane insertase activity
C2E46_RS02670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2E46_RS02675	COG3328	transposase activity
C2E46_RS02680	COG1216	Glycosyl transferase, family 2
C2E46_RS02680	COG1442	glycosyl transferase family 8
C2E46_RS02710	COG3328	transposase activity
C2E46_RS02740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2E46_RS02750	COG0789	Transcriptional regulator
C2E46_RS02760	COG0656	L-ascorbic acid biosynthetic process
C2E46_RS02815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2E46_RS02840	COG0673	inositol 2-dehydrogenase activity
C2E46_RS02850	COG2315	Protein conserved in bacteria
C2E46_RS02865	COG0742	ribosomal rna small subunit methyltransferase
C2E46_RS02880	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2E46_RS02885	COG0737	Belongs to the 5'-nucleotidase family
C2E46_RS02890	COG4470	Protein conserved in bacteria
C2E46_RS02905	COG1132	(ABC) transporter
C2E46_RS02910	COG1132	(ABC) transporter
C2E46_RS02915	COG0512	Glutamine amidotransferase of anthranilate synthase
C2E46_RS02930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2E46_RS02950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2E46_RS02965	COG1940	carbohydrate kinase activity
C2E46_RS02970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2E46_RS02985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2E46_RS03010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2E46_RS03020	COG0762	integral membrane protein
C2E46_RS03025	COG2302	S4 RNA-binding domain
C2E46_RS03030	COG3599	regulation of cell shape
C2E46_RS03035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2E46_RS03045	COG0494	nUDIX hydrolase
C2E46_RS03055	COG4703	Protein of unknown function (DUF1797)
C2E46_RS03060	COG3344	reverse transcriptase
C2E46_RS03065	COG0765	amino acid transport
C2E46_RS03070	COG1126	abc transporter atp-binding protein
C2E46_RS03075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2E46_RS03085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2E46_RS03090	COG1570	exodeoxyribonuclease VII activity
C2E46_RS03105	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2E46_RS03110	COG1438	arginine binding
C2E46_RS03115	COG0497	DNA recombination
C2E46_RS03120	COG1307	EDD domain protein, DegV family
C2E46_RS03125	COG2755	lipolytic protein G-D-S-L family
C2E46_RS03180	COG1078	dGTPase activity
C2E46_RS03200	COG3328	transposase activity
C2E46_RS03215	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2E46_RS03225	COG2884	Cell division ATP-binding protein ftsE
C2E46_RS03230	COG2177	Part of the ABC transporter FtsEX involved in
C2E46_RS03255	COG3344	reverse transcriptase
C2E46_RS03260	COG1199	ATP-dependent helicase activity
C2E46_RS03260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2E46_RS03265	COG0436	Aminotransferase
C2E46_RS03315	COG0254	rRNA binding
C2E46_RS03320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2E46_RS03325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2E46_RS03330	COG0716	FMN binding
C2E46_RS03335	COG1605	Chorismate mutase
C2E46_RS03335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2E46_RS03340	COG0038	chloride channel
C2E46_RS03355	COG0582	viral genome integration into host DNA
C2E46_RS03385	COG3237	CsbD-like
C2E46_RS03395	COG0772	Belongs to the SEDS family
C2E46_RS03415	COG0560	Phosphoserine phosphatase
C2E46_RS03450	COG1316	TRANSCRIPTIONal
C2E46_RS03455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2E46_RS03465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2E46_RS03470	COG4555	ABC transporter
C2E46_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
C2E46_RS03500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2E46_RS03505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2E46_RS03525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2E46_RS03530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2E46_RS03555	COG3344	reverse transcriptase
C2E46_RS03560	COG3590	peptidase
C2E46_RS03565	COG3590	peptidase
C2E46_RS03590	COG1136	(ABC) transporter
C2E46_RS03610	COG0586	Pfam SNARE associated Golgi protein
C2E46_RS03615	COG4619	ABC transporter
C2E46_RS03620	COG0390	transport system, permease component
C2E46_RS03630	COG0583	DNA-binding transcription factor activity
C2E46_RS03640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2E46_RS03645	COG2211	Major facilitator Superfamily
C2E46_RS03655	COG3250	beta-galactosidase activity
C2E46_RS03660	COG2186	Transcriptional regulator
C2E46_RS03665	COG0800	Aldolase
C2E46_RS03675	COG1312	Catalyzes the dehydration of D-mannonate
C2E46_RS03680	COG1028	Short-chain dehydrogenase reductase Sdr
C2E46_RS03700	COG1609	Transcriptional regulator
C2E46_RS03715	COG0438	transferase activity, transferring glycosyl groups
C2E46_RS03745	COG0765	amino acid transport
C2E46_RS03750	COG0765	amino acid transport
C2E46_RS03755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E46_RS03760	COG1126	abc transporter atp-binding protein
C2E46_RS03765	COG0745	RESPONSE REGULATOR receiver
C2E46_RS03770	COG5002	protein histidine kinase activity
C2E46_RS03775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2E46_RS03780	COG2832	Protein of unknown function (DUF454)
C2E46_RS03790	COG1196	nuclear chromosome segregation
C2E46_RS03825	COG4372	Transposase
C2E46_RS03875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E46_RS03875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2E46_RS03920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2E46_RS03940	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2E46_RS03980	COG4695	Portal protein
C2E46_RS03985	COG0740	serine-type endopeptidase activity
C2E46_RS04050	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2E46_RS04050	COG1388	LysM domain
C2E46_RS04075	COG0561	phosphatase activity
C2E46_RS04080	COG0552	protein localization to endoplasmic reticulum
C2E46_RS04085	COG3344	reverse transcriptase
C2E46_RS04090	COG3689	TIGRFAM TIGR03943 family protein
C2E46_RS04095	COG0701	Predicted permease
C2E46_RS04110	COG2183	response to ionizing radiation
C2E46_RS04115	COG3091	SprT-like family
C2E46_RS04120	COG1983	PspC domain protein
C2E46_RS04165	COG4443	Transcriptional Coactivator p15 (PC4)
C2E46_RS04175	COG1914	H( )-stimulated, divalent metal cation uptake system
C2E46_RS04205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2E46_RS04220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2E46_RS04250	COG1164	Oligoendopeptidase f
C2E46_RS04260	COG0772	Belongs to the SEDS family
C2E46_RS04280	COG0768	penicillin binding
C2E46_RS04295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2E46_RS04300	COG2223	nitrite transmembrane transporter activity
C2E46_RS04325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2E46_RS04330	COG2011	ABC-type metal ion transport system permease component
C2E46_RS04335	COG1464	Belongs to the NlpA lipoprotein family
C2E46_RS04340	COG0513	Belongs to the DEAD box helicase family
C2E46_RS04350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2E46_RS04355	COG0204	Acyl-transferase
C2E46_RS04360	COG1596	polysaccharide export
C2E46_RS04360	COG1555	photosystem II stabilization
C2E46_RS04365	COG0658	competence protein
C2E46_RS04365	COG2333	competence protein COMEC
C2E46_RS04370	COG0561	phosphatase activity
C2E46_RS04375	COG1609	Transcriptional regulator
C2E46_RS04380	COG0657	acetylesterase activity
C2E46_RS04385	COG2226	methyltransferase
C2E46_RS04395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2E46_RS04400	COG3711	transcriptional antiterminator
C2E46_RS04405	COG1263	PTS System
C2E46_RS04405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E46_RS04405	COG2190	(PTS) system
C2E46_RS04415	COG3835	regulator
C2E46_RS04420	COG1929	Belongs to the glycerate kinase type-1 family
C2E46_RS04425	COG2610	gluconate transmembrane transporter activity
C2E46_RS04435	COG1846	Transcriptional regulator
C2E46_RS04440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2E46_RS04455	COG0435	Glutathione S-transferase
C2E46_RS04460	COG1187	pseudouridine synthase activity
C2E46_RS04480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2E46_RS04495	COG4894	glucomannan catabolic process
C2E46_RS04510	COG1442	glycosyl transferase family 8
C2E46_RS04520	COG1476	TRANSCRIPTIONal
C2E46_RS04535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2E46_RS04540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2E46_RS04545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2E46_RS04560	COG1012	belongs to the aldehyde dehydrogenase family
C2E46_RS04565	COG0726	polysaccharide deacetylase
C2E46_RS04570	COG0513	Belongs to the DEAD box helicase family
C2E46_RS04580	COG1956	GAF domain-containing protein
C2E46_RS04585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2E46_RS04595	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2E46_RS04595	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2E46_RS04600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2E46_RS04630	COG4721	ABC-type cobalt transport system, permease component
C2E46_RS04635	COG1122	ATPase activity
C2E46_RS04645	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2E46_RS04655	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C2E46_RS04665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2E46_RS04675	COG4109	DRTGG domain
C2E46_RS04680	COG0024	Methionine aminopeptidase
C2E46_RS04690	COG2246	polysaccharide biosynthetic process
C2E46_RS04695	COG4708	membrane
C2E46_RS04700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2E46_RS04705	COG1597	lipid kinase activity
C2E46_RS04710	COG1523	belongs to the glycosyl hydrolase 13 family
C2E46_RS04720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2E46_RS04750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2E46_RS04770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2E46_RS04805	COG0072	phenylalanine-tRNA ligase activity
C2E46_RS04805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E46_RS04810	COG2321	neutral zinc metallopeptidase
C2E46_RS04820	COG1074	ATP-dependent DNA helicase activity
C2E46_RS04830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2E46_RS04835	COG0488	(ABC) transporter
C2E46_RS04840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2E46_RS04845	COG0022	dehydrogenase e1 component
C2E46_RS04845	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2E46_RS04850	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2E46_RS04860	COG0095	Lipoate-protein ligase
C2E46_RS04865	COG3442	glutamine amidotransferase
C2E46_RS04870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2E46_RS04875	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2E46_RS04905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2E46_RS04915	COG0647	UMP catabolic process
C2E46_RS04925	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C2E46_RS04930	COG1518	maintenance of DNA repeat elements
C2E46_RS04935	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C2E46_RS04960	COG3344	reverse transcriptase
C2E46_RS04965	COG1418	mRNA catabolic process
C2E46_RS04970	COG0456	acetyltransferase
C2E46_RS04980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2E46_RS05010	COG3620	sequence-specific DNA binding
C2E46_RS05070	COG3561	AntA/AntB antirepressor
C2E46_RS05115	COG1484	DNA-dependent DNA replication
C2E46_RS05335	COG1131	(ABC) transporter
C2E46_RS05340	COG1725	Transcriptional regulator
C2E46_RS05355	COG0469	pyruvate kinase activity
C2E46_RS05365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2E46_RS05370	COG2824	Alkylphosphonate utilization operon protein PhnA
C2E46_RS05375	COG0765	amino acid transport
C2E46_RS05380	COG1126	abc transporter atp-binding protein
C2E46_RS05400	COG2813	Specifically methylates the guanine in position
C2E46_RS05410	COG1744	ABC transporter substrate-binding protein PnrA-like
C2E46_RS05450	COG3764	Sortase (surface protein transpeptidase)
C2E46_RS05455	COG0346	lactoylglutathione lyase activity
C2E46_RS05485	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C2E46_RS05495	COG1464	Belongs to the NlpA lipoprotein family
C2E46_RS05520	COG0745	RESPONSE REGULATOR receiver
C2E46_RS05525	COG5002	protein histidine kinase activity
C2E46_RS05535	COG4166	transmembrane transport
C2E46_RS05550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2E46_RS05555	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C2E46_RS05560	COG5002	protein histidine kinase activity
C2E46_RS05565	COG0745	RESPONSE REGULATOR receiver
C2E46_RS05575	COG0704	Plays a role in the regulation of phosphate uptake
C2E46_RS05590	COG0581	inorganic phosphate transmembrane transporter activity
C2E46_RS05595	COG0573	inorganic phosphate transmembrane transporter activity
C2E46_RS05600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2E46_RS05605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2E46_RS05605	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2E46_RS05615	COG4476	Belongs to the UPF0223 family
C2E46_RS05620	COG1393	Belongs to the ArsC family
C2E46_RS05625	COG0196	riboflavin kinase activity
C2E46_RS05660	COG1136	(ABC) transporter
C2E46_RS05665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2E46_RS05670	COG0758	DNA mediated transformation
C2E46_RS05675	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2E46_RS05680	COG4604	ABC transporter, ATP-binding protein
C2E46_RS05685	COG4605	iron ion homeostasis
C2E46_RS05690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2E46_RS05695	COG0110	maltose O-acetyltransferase activity
C2E46_RS05700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2E46_RS05705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2E46_RS05710	COG1376	ErfK ybiS ycfS ynhG family protein
C2E46_RS05715	COG1966	Carbon starvation protein
C2E46_RS05720	COG3279	Response regulator of the LytR AlgR family
C2E46_RS05725	COG3275	phosphorelay sensor kinase activity
C2E46_RS05855	COG0505	Belongs to the CarA family
C2E46_RS05865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2E46_RS05870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2E46_RS05875	COG0284	orotidine-5'-phosphate decarboxylase activity
C2E46_RS05885	COG0488	(ABC) transporter
C2E46_RS05895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2E46_RS05910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2E46_RS05960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2E46_RS05965	COG4684	Psort location CytoplasmicMembrane, score
C2E46_RS05970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2E46_RS05975	COG3344	reverse transcriptase
C2E46_RS05985	COG1132	(ABC) transporter
C2E46_RS06015	COG2890	protein-(glutamine-N5) methyltransferase activity
C2E46_RS06020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2E46_RS06045	COG3976	FMN-binding domain protein
C2E46_RS06045	COG0431	NADPH-dependent FMN reductase
C2E46_RS06045	COG1053	succinate dehydrogenase
C2E46_RS06060	COG2233	PERMEase
C2E46_RS06075	COG0477	Major facilitator Superfamily
C2E46_RS06090	COG4221	oxidoreductase activity
C2E46_RS06095	COG0280	phosphate acetyltransferase
C2E46_RS06100	COG0564	pseudouridine synthase activity
C2E46_RS06110	COG2357	RelA SpoT domain protein
C2E46_RS06120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2E46_RS06125	COG1104	cysteine desulfurase activity
C2E46_RS06145	COG0628	permease
C2E46_RS06150	COG2723	6-phospho-beta-galactosidase activity
C2E46_RS06160	COG0561	phosphatase activity
C2E46_RS06170	COG0038	chloride channel
C2E46_RS06175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2E46_RS06180	COG1177	transmembrane transport
C2E46_RS06185	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2E46_RS06220	COG0285	dihydrofolate synthase activity
C2E46_RS06225	COG2962	Rard protein
C2E46_RS06250	COG1012	belongs to the aldehyde dehydrogenase family
C2E46_RS06350	COG1115	amino acid carrier protein
C2E46_RS06355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2E46_RS06365	COG1346	cytolysis
C2E46_RS06385	COG0539	negative regulation of cytoplasmic translation
C2E46_RS06405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2E46_RS06415	COG0187	DNA topoisomerase II activity
C2E46_RS06420	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2E46_RS06450	COG2089	acid synthase
C2E46_RS06475	COG1216	Glycosyl transferase, family 2
C2E46_RS06475	COG1442	glycosyl transferase family 8
C2E46_RS06480	COG1216	Glycosyl transferase, family 2
C2E46_RS06480	COG1442	glycosyl transferase family 8
C2E46_RS06495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2E46_RS06520	COG1316	TRANSCRIPTIONal
C2E46_RS06545	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2E46_RS06580	COG3842	ATPase activity
C2E46_RS06600	COG3527	Alpha-acetolactate decarboxylase
C2E46_RS06605	COG0028	Belongs to the TPP enzyme family
C2E46_RS06610	COG0457	Tetratricopeptide repeat
C2E46_RS06615	COG0628	permease
C2E46_RS06625	COG1051	belongs to the nudix hydrolase family
C2E46_RS06630	COG5492	domain, Protein
C2E46_RS06635	COG1088	dTDP-glucose 4,6-dehydratase activity
C2E46_RS06640	COG0135	phosphoribosylanthranilate isomerase activity
C2E46_RS06650	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2E46_RS06655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2E46_RS06665	COG2384	SAM-dependent methyltransferase
C2E46_RS06675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2E46_RS06685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2E46_RS06685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2E46_RS06690	COG0300	oxidoreductase activity
C2E46_RS06735	COG1573	uracil-dna glycosylase
C2E46_RS06740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2E46_RS06750	COG0584	glycerophosphoryl diester phosphodiesterase
C2E46_RS06765	COG0534	Mate efflux family protein
C2E46_RS06790	COG4974	Belongs to the 'phage' integrase family
C2E46_RS06800	COG1396	sequence-specific DNA binding
C2E46_RS06875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2E46_RS07040	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2E46_RS07065	COG2040	homocysteine
C2E46_RS07070	COG0833	amino acid
C2E46_RS07100	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2E46_RS07110	COG3425	synthase
C2E46_RS07125	COG1272	protein, Hemolysin III
C2E46_RS07170	COG0745	RESPONSE REGULATOR receiver
C2E46_RS07175	COG2357	RelA SpoT domain protein
C2E46_RS07195	COG0737	Belongs to the 5'-nucleotidase family
C2E46_RS07200	COG0242	peptide deformylase activity
C2E46_RS07205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2E46_RS07215	COG1132	(ABC) transporter
C2E46_RS07220	COG1132	(ABC) transporter
C2E46_RS07230	COG0488	(ABC) transporter
C2E46_RS07235	COG0617	tRNA 3'-terminal CCA addition
C2E46_RS07260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2E46_RS07260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E46_RS07260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2E46_RS07265	COG1105	Belongs to the carbohydrate kinase PfkB family
C2E46_RS07270	COG1349	DNA-binding transcription factor activity
C2E46_RS07275	COG1388	LysM domain
C2E46_RS07275	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E46_RS07305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2E46_RS07325	COG1837	Belongs to the UPF0109 family
C2E46_RS07335	COG0577	efflux transmembrane transporter activity
C2E46_RS07340	COG1136	(ABC) transporter
C2E46_RS07345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2E46_RS07360	COG0505	Belongs to the CarA family
C2E46_RS07370	COG0564	pseudouridine synthase activity
C2E46_RS07380	COG0583	DNA-binding transcription factor activity
C2E46_RS07385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2E46_RS07405	COG0301	tRNA thio-modification
C2E46_RS07410	COG1104	cysteine desulfurase activity
C2E46_RS07420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2E46_RS07445	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2E46_RS07450	COG3328	transposase activity
C2E46_RS07455	COG1368	sulfuric ester hydrolase activity
C2E46_RS07500	COG2244	polysaccharide biosynthetic process
C2E46_RS07505	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2E46_RS07510	COG1120	ATPase activity
C2E46_RS07515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2E46_RS07520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2E46_RS07525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2E46_RS07540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2E46_RS07545	COG1253	flavin adenine dinucleotide binding
C2E46_RS07550	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2E46_RS07555	COG1242	4 iron, 4 sulfur cluster binding
C2E46_RS07560	COG0671	phosphoesterase, PA-phosphatase related
C2E46_RS07565	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2E46_RS07595	COG0681	Belongs to the peptidase S26 family
C2E46_RS07610	COG0297	glycogen (starch) synthase activity
C2E46_RS07650	COG3475	LICD family
C2E46_RS07665	COG0463	Glycosyl transferase, family 2
C2E46_RS07670	COG1215	transferase activity, transferring glycosyl groups
C2E46_RS07680	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2E46_RS07685	COG2151	metal-sulfur cluster biosynthetic enzyme
C2E46_RS07690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2E46_RS07695	COG0358	DNA primase activity
C2E46_RS07700	COG1970	mechanosensitive ion channel activity
C2E46_RS07715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E46_RS07720	COG0004	ammonium transporteR
C2E46_RS07745	COG0058	SHG alpha-glucan phosphorylase activity
C2E46_RS07750	COG1640	4-alpha-glucanotransferase
C2E46_RS07755	COG1609	Transcriptional regulator
C2E46_RS07765	COG1175	transmembrane transport
C2E46_RS07770	COG3833	ABC-type maltose transport systems, permease component
C2E46_RS07775	COG3104	oligopeptide transport
C2E46_RS07795	COG0438	transferase activity, transferring glycosyl groups
C2E46_RS07820	COG0201	protein transport
C2E46_RS07825	COG1442	glycosyl transferase family 8
C2E46_RS07830	COG1442	glycosyl transferase family 8
C2E46_RS07830	COG1216	Glycosyl transferase, family 2
C2E46_RS07835	COG1442	glycosyl transferase family 8
C2E46_RS07860	COG3328	transposase activity
C2E46_RS07880	COG0765	amino acid transport
C2E46_RS07885	COG1126	abc transporter atp-binding protein
C2E46_RS07890	COG3344	reverse transcriptase
C2E46_RS07915	COG2309	aminopeptidase activity
C2E46_RS07930	COG1187	pseudouridine synthase activity
C2E46_RS07940	COG0656	L-ascorbic acid biosynthetic process
C2E46_RS07945	COG0778	Nitroreductase
C2E46_RS07950	COG0346	lactoylglutathione lyase activity
C2E46_RS07955	COG0463	Glycosyl transferase, family 2
C2E46_RS07960	COG1113	amino acid transport
C2E46_RS07970	COG0557	exoribonuclease II activity
C2E46_RS07985	COG2814	Major facilitator Superfamily
C2E46_RS07995	COG1131	(ABC) transporter
C2E46_RS08035	COG3328	transposase activity
C2E46_RS08055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2E46_RS08080	COG1702	phosphate starvation-inducible protein PhoH
C2E46_RS08120	COG0444	Belongs to the ABC transporter superfamily
C2E46_RS08125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2E46_RS08135	COG0747	negative chemotaxis
C2E46_RS08145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2E46_RS08155	COG1473	amidohydrolase
C2E46_RS08160	COG0583	DNA-binding transcription factor activity
C2E46_RS08170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2E46_RS08175	COG1674	ftsk spoiiie
C2E46_RS08180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2E46_RS08205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2E46_RS08240	COG0673	inositol 2-dehydrogenase activity
C2E46_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
C2E46_RS08280	COG1215	transferase activity, transferring glycosyl groups
C2E46_RS08305	COG3344	reverse transcriptase
C2E46_RS08315	COG1114	Component of the transport system for branched-chain amino acids
C2E46_RS08320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E46_RS08320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2E46_RS08335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E46_RS08345	COG0708	Exodeoxyribonuclease III
C2E46_RS08350	COG1393	Belongs to the ArsC family
C2E46_RS08355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2E46_RS08360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2E46_RS08370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2E46_RS08390	COG0470	DNA polymerase III
C2E46_RS08400	COG0517	IMP dehydrogenase activity
C2E46_RS08405	COG0410	ABC transporter
C2E46_RS08410	COG0411	ABC transporter
C2E46_RS08420	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2E46_RS08445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2E46_RS08455	COG0531	amino acid
C2E46_RS08460	COG0569	domain protein
C2E46_RS08465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2E46_RS08475	COG1187	pseudouridine synthase activity
C2E46_RS08505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2E46_RS08510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2E46_RS08525	COG1827	regulation of RNA biosynthetic process
C2E46_RS08540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2E46_RS08545	COG1254	Belongs to the acylphosphatase family
C2E46_RS08555	COG0765	amino acid transport
C2E46_RS08560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E46_RS08575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2E46_RS08595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2E46_RS08605	COG1484	DNA-dependent DNA replication
C2E46_RS08620	COG5002	protein histidine kinase activity
C2E46_RS08625	COG0745	RESPONSE REGULATOR receiver
C2E46_RS08635	COG0501	Belongs to the peptidase M48B family
C2E46_RS08640	COG1704	LemA family
C2E46_RS08645	COG0357	Ribosomal RNA small subunit methyltransferase G
C2E46_RS08650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2E46_RS08655	COG0569	domain protein
C2E46_RS08665	COG1122	ATPase activity
C2E46_RS08680	COG1114	Component of the transport system for branched-chain amino acids
C2E46_RS08685	COG1063	alcohol dehydrogenase
C2E46_RS08710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2E46_RS08715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2E46_RS08725	COG2376	Dihydroxyacetone kinase
C2E46_RS08730	COG1309	transcriptional regulator
C2E46_RS08735	COG2376	Dihydroxyacetone kinase
C2E46_RS08740	COG1461	Dihydroxyacetone kinase
C2E46_RS08745	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C2E46_RS08750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2E46_RS08765	COG1323	Belongs to the UPF0348 family
C2E46_RS08775	COG2226	methyltransferase
C2E46_RS08780	COG0799	negative regulation of ribosome biogenesis
C2E46_RS08790	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2E46_RS08795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2E46_RS08800	COG1534	Rna-binding protein
C2E46_RS08805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2E46_RS08810	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2E46_RS08825	COG0154	amidase activity
C2E46_RS08830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2E46_RS08835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2E46_RS08835	COG0574	Belongs to the PEP-utilizing enzyme family
C2E46_RS08845	COG0517	IMP dehydrogenase activity
C2E46_RS08855	COG1335	isochorismatase
C2E46_RS08860	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2E46_RS08865	COG0436	Aminotransferase
C2E46_RS08870	COG0589	response to stress
C2E46_RS08875	COG0561	phosphatase activity
C2E46_RS08880	COG0252	asparaginase activity
C2E46_RS08890	COG4989	oxidoreductase activity
C2E46_RS08895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2E46_RS08900	COG3942	CHAP domain
C2E46_RS08900	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E46_RS08915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2E46_RS08925	COG1482	cell wall glycoprotein biosynthetic process
C2E46_RS08930	COG1940	carbohydrate kinase activity
C2E46_RS08935	COG1263	PTS System
C2E46_RS08935	COG2190	(PTS) system
C2E46_RS08935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E46_RS08940	COG1621	beta-fructofuranosidase activity
C2E46_RS08945	COG1609	Transcriptional regulator
C2E46_RS08970	COG1132	(ABC) transporter
C2E46_RS09010	COG2131	deaminase
C2E46_RS09015	COG0006	proline dipeptidase activity
C2E46_RS09050	COG0629	single-stranded DNA binding
C2E46_RS09060	COG1194	a g-specific adenine glycosylase
C2E46_RS09070	COG3118	belongs to the thioredoxin family
C2E46_RS09100	COG0681	Belongs to the peptidase S26 family
C2E46_RS09105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2E46_RS09125	COG1882	Formate acetyltransferase
C2E46_RS09130	COG3576	pyridoxamine 5-phosphate
C2E46_RS09135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2E46_RS09150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2E46_RS09160	COG2814	Major facilitator Superfamily
C2E46_RS09165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2E46_RS09180	COG0142	geranyltranstransferase activity
C2E46_RS09185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2E46_RS09190	COG4988	ABC transporter
C2E46_RS09195	COG1294	oxidase, subunit
C2E46_RS09200	COG1271	oxidase subunit
C2E46_RS09205	COG1252	NADH dehydrogenase
C2E46_RS09225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2E46_RS09230	COG0789	Transcriptional regulator
C2E46_RS09245	COG2081	HI0933 family
C2E46_RS09270	COG0456	acetyltransferase
C2E46_RS09275	COG1214	PFAM Peptidase M22, glycoprotease
C2E46_RS09290	COG3942	CHAP domain
C2E46_RS09295	COG0174	glutamine synthetase
C2E46_RS09300	COG0789	Transcriptional regulator
C2E46_RS09315	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C2E46_RS09340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2E46_RS09350	COG1322	Protein conserved in bacteria
C2E46_RS09365	COG1162	GTPase activity
C2E46_RS09390	COG0084	hydrolase, TatD family'
C2E46_RS09415	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2E46_RS09425	COG1696	Membrane protein involved in D-alanine export
C2E46_RS09440	COG5002	protein histidine kinase activity
C2E46_RS09445	COG0745	RESPONSE REGULATOR receiver
C2E46_RS09460	COG3328	transposase activity
C2E46_RS09470	COG4175	Glycine betaine
C2E46_RS09470	COG3448	diguanylate cyclase activity
C2E46_RS09475	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C2E46_RS09495	COG1070	Carbohydrate kinase
C2E46_RS09505	COG3775	system Galactitol-specific IIC component
C2E46_RS09510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2E46_RS09520	COG1609	Transcriptional regulator
C2E46_RS09525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2E46_RS09555	COG3037	sugar-specific permease SgaT UlaA
C2E46_RS09575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2E46_RS09590	COG2918	glutathione biosynthetic process
C2E46_RS09590	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2E46_RS09610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2E46_RS09615	COG1428	Deoxynucleoside kinase
C2E46_RS09625	COG0542	response to heat
C2E46_RS09630	COG4463	regulation of RNA biosynthetic process
C2E46_RS09645	COG0052	Belongs to the universal ribosomal protein uS2 family
C2E46_RS09650	COG0450	alkyl hydroperoxide reductase
C2E46_RS09665	COG0025	NhaP-type Na H and K H
C2E46_RS09675	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2E46_RS09680	COG3590	peptidase
C2E46_RS09705	COG1609	Transcriptional regulator
C2E46_RS09715	COG3344	reverse transcriptase
C2E46_RS09720	COG3716	PTS system mannose fructose sorbose family IID component
C2E46_RS09725	COG3715	PTS system
C2E46_RS09730	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E46_RS09735	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2E46_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
C2E46_RS09785	COG2176	DNA-directed DNA polymerase activity
C2E46_RS09790	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2E46_RS09790	COG1388	LysM domain
C2E46_RS09805	COG4589	Belongs to the CDS family
C2E46_RS09810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2E46_RS09815	COG1862	Preprotein translocase
C2E46_RS09835	COG3493	citrate carrier protein
C2E46_RS09845	COG4565	transcriptional regulatory protein
C2E46_RS09850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2E46_RS09860	COG3842	ATPase activity
C2E46_RS09910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E46_RS09910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2E46_RS09915	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2E46_RS09945	COG0347	Belongs to the P(II) protein family
C2E46_RS09950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E46_RS09955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2E46_RS09955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2E46_RS09955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2E46_RS09960	COG1105	Belongs to the carbohydrate kinase PfkB family
C2E46_RS09965	COG1737	Transcriptional regulator
C2E46_RS09970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2E46_RS09985	COG0698	ribose 5-phosphate isomerase
C2E46_RS09990	COG0698	ribose 5-phosphate isomerase
C2E46_RS09995	COG3328	transposase activity
C2E46_RS10035	COG1490	D-aminoacyl-tRNA deacylase activity
C2E46_RS10045	COG0737	Belongs to the 5'-nucleotidase family
C2E46_RS10055	COG1363	Peptidase, m42
C2E46_RS10070	COG4753	response regulator
C2E46_RS10070	COG2207	Transcriptional regulator
C2E46_RS10075	COG2972	Histidine kinase
C2E46_RS10080	COG3716	PTS system mannose fructose sorbose family IID component
C2E46_RS10085	COG3715	PTS system
C2E46_RS10110	COG1131	(ABC) transporter
C2E46_RS10130	COG1263	PTS System
C2E46_RS10130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2E46_RS10130	COG2190	(PTS) system
C2E46_RS10135	COG5002	protein histidine kinase activity
C2E46_RS10140	COG0745	RESPONSE REGULATOR receiver
C2E46_RS10150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2E46_RS10155	COG0581	inorganic phosphate transmembrane transporter activity
C2E46_RS10160	COG0573	inorganic phosphate transmembrane transporter activity
C2E46_RS10165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2E46_RS10175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2E46_RS10180	COG2264	protein methyltransferase activity
C2E46_RS10190	COG0789	Transcriptional regulator
C2E46_RS10215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2E46_RS10225	COG0582	viral genome integration into host DNA
C2E46_RS10265	COG0433	COG0433 Predicted ATPase
C2E46_RS10285	COG4115	mRNA cleavage
C2E46_RS10320	COG3620	sequence-specific DNA binding
C2E46_RS10335	COG1674	ftsk spoiiie
C2E46_RS10390	COG1396	sequence-specific DNA binding
C2E46_RS10425	COG1914	H( )-stimulated, divalent metal cation uptake system
C2E46_RS10435	COG1131	(ABC) transporter
C2E46_RS10445	COG1994	Peptidase M50
C2E46_RS10450	COG0535	radical SAM domain protein
C2E46_RS10490	COG0433	COG0433 Predicted ATPase
C2E46_RS10550	COG1674	ftsk spoiiie
C2E46_RS10595	COG1396	sequence-specific DNA binding
C2E46_RS10635	COG1136	(ABC) transporter
C2E46_RS10640	COG0577	efflux transmembrane transporter activity
C2E46_RS10675	COG2897	thiosulfate sulfurtransferase activity
C2E46_RS10690	COG0371	Dehydrogenase
C2E46_RS10700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2E46_RS10700	COG0646	methionine synthase
C2E46_RS10725	COG0745	RESPONSE REGULATOR receiver
C2E46_RS10730	COG2205	protein histidine kinase activity
C2E46_RS10730	COG2770	Histidine kinase
C2E46_RS10745	COG2814	Major facilitator Superfamily
C2E46_RS10750	COG4667	esterase of the alpha-beta hydrolase superfamily
C2E46_RS10775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2E46_RS10780	COG0564	pseudouridine synthase activity
C2E46_RS10800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2E46_RS10805	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C2E46_RS10825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2E46_RS10830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2E46_RS10830	COG1116	anion transmembrane transporter activity
C2E46_RS10835	COG4120	Belongs to the binding-protein-dependent transport system permease family
C2E46_RS10845	COG0561	phosphatase activity
C2E46_RS10850	COG2514	catechol 2,3-dioxygenase activity
C2E46_RS10855	COG3022	response to hydroperoxide
C2E46_RS10860	COG0602	queuosine metabolic process
C2E46_RS10875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2E46_RS10875	COG1328	CTP reductase activity
C2E46_RS10885	COG3906	Belongs to the UPF0473 family
C2E46_RS10900	COG1393	Belongs to the ArsC family
C2E46_RS10905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2E46_RS10910	COG1058	Belongs to the CinA family
C2E46_RS10910	COG1546	Belongs to the CinA family
C2E46_RS10915	COG2818	Glycosylase
C2E46_RS10940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2E46_RS10960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2E46_RS10965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2E46_RS10970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2E46_RS11050	COG3328	transposase activity
C2E46_RS11080	COG0745	RESPONSE REGULATOR receiver
C2E46_RS11090	COG1288	antiporter activity
C2E46_RS11100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2E46_RS11105	COG3852	Histidine kinase
C2E46_RS11110	COG0784	Response regulator, receiver
C2E46_RS11115	COG1125	glycine betaine transport
C2E46_RS11115	COG0517	IMP dehydrogenase activity
C2E46_RS11120	COG1174	glycine betaine transport
C2E46_RS11125	COG0392	lysyltransferase activity
C2E46_RS11125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2E46_RS11135	COG3759	membrane
C2E46_RS11165	COG0305	Participates in initiation and elongation during chromosome replication
C2E46_RS11185	COG2095	MarC family integral membrane protein
C2E46_RS11190	COG0482	sulfurtransferase activity
C2E46_RS11195	COG1760	l-serine dehydratase
C2E46_RS11200	COG1760	l-serine dehydratase
C2E46_RS11205	COG0741	lytic transglycosylase activity
C2E46_RS11210	COG1388	LysM domain
C2E46_RS11230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2E46_RS11235	COG0612	Peptidase, M16
C2E46_RS11240	COG0612	Peptidase, M16
C2E46_RS11245	COG2501	S4 domain
C2E46_RS11260	COG4975	Glucose uptake
C2E46_RS11280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2E46_RS11290	COG2235	arginine
C2E46_RS11310	COG0549	Belongs to the carbamate kinase family
C2E46_RS11320	COG0180	Tryptophanyl-tRNA synthetase
C2E46_RS11335	COG0488	(ABC) transporter
C2E46_RS11340	COG4485	Bacterial membrane protein, YfhO
C2E46_RS11365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2E46_RS11370	COG1475	DNA binding