locus-tag	class	description
DK43_RS00030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DK43_RS00035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DK43_RS00040	COG0037	tRNA processing
DK43_RS00055	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DK43_RS00060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DK43_RS00065	COG0193	aminoacyl-tRNA hydrolase activity
DK43_RS00070	COG0012	GTP binding
DK43_RS00085	COG0592	DNA-directed DNA polymerase activity
DK43_RS00095	COG1475	DNA binding
DK43_RS00100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DK43_RS00105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DK43_RS00150	COG0488	(ABC) transporter
DK43_RS00160	COG0149	triose-phosphate isomerase activity
DK43_RS00165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DK43_RS00170	COG0180	Tryptophanyl-tRNA synthetase
DK43_RS00175	COG0517	IMP dehydrogenase activity
DK43_RS00175	COG0516	GMP reductase activity
DK43_RS00180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DK43_RS00190	COG0612	Peptidase, M16
DK43_RS00195	COG0612	Peptidase, M16
DK43_RS00205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DK43_RS00210	COG1122	ATPase activity
DK43_RS00215	COG1122	ATPase activity
DK43_RS00220	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DK43_RS00235	COG1760	l-serine dehydratase
DK43_RS00240	COG1760	l-serine dehydratase
DK43_RS00250	COG0482	sulfurtransferase activity
DK43_RS00255	COG0445	tRNA wobble uridine modification
DK43_RS00270	COG0305	Participates in initiation and elongation during chromosome replication
DK43_RS00280	COG1011	Hydrolase
DK43_RS00300	COG0561	phosphatase activity
DK43_RS00365	COG1696	Membrane protein involved in D-alanine export
DK43_RS00370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DK43_RS00375	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DK43_RS00380	COG0561	phosphatase activity
DK43_RS00385	COG2094	Belongs to the DNA glycosylase MPG family
DK43_RS00390	COG2807	transmembrane transport
DK43_RS00420	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DK43_RS00455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DK43_RS00460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DK43_RS00465	COG0124	histidyl-tRNA synthetase
DK43_RS00480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DK43_RS00485	COG1523	belongs to the glycosyl hydrolase 13 family
DK43_RS00490	COG1609	Transcriptional regulator
DK43_RS00495	COG5521	maltodextrose utilization protein MalA
DK43_RS00500	COG3833	ABC-type maltose transport systems, permease component
DK43_RS00505	COG1175	transmembrane transport
DK43_RS00510	COG2182	Extracellular solute-binding protein
DK43_RS00515	COG1640	4-alpha-glucanotransferase
DK43_RS00520	COG0058	SHG alpha-glucan phosphorylase activity
DK43_RS00530	COG1780	Probably involved in ribonucleotide reductase function
DK43_RS00535	COG0018	arginyl-trna synthetase
DK43_RS00540	COG1438	arginine binding
DK43_RS00545	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DK43_RS00640	COG0582	viral genome integration into host DNA
DK43_RS00645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DK43_RS00650	COG0632	four-way junction helicase activity
DK43_RS00655	COG2818	Glycosylase
DK43_RS00670	COG1058	Belongs to the CinA family
DK43_RS00670	COG1546	Belongs to the CinA family
DK43_RS00675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DK43_RS00680	COG1393	Belongs to the ArsC family
DK43_RS00695	COG4472	Bacterial protein of unknown function (DUF965)
DK43_RS00700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DK43_RS00705	COG3906	Belongs to the UPF0473 family
DK43_RS00710	COG0285	dihydrofolate synthase activity
DK43_RS00720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DK43_RS00745	COG0602	queuosine metabolic process
DK43_RS00755	COG4464	protein tyrosine phosphatase activity
DK43_RS00760	COG3944	biosynthesis protein
DK43_RS00790	COG0438	transferase activity, transferring glycosyl groups
DK43_RS00810	COG3475	LICD family
DK43_RS00835	COG4750	Nucleotidyl transferase
DK43_RS00865	COG5002	protein histidine kinase activity
DK43_RS00870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DK43_RS00870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DK43_RS00875	COG1832	CoA-binding protein
DK43_RS00905	COG1832	CoA-binding protein
DK43_RS00910	COG0572	uridine kinase
DK43_RS00925	COG0343	queuine tRNA-ribosyltransferase activity
DK43_RS00930	COG0051	transcription antitermination factor activity, RNA binding
DK43_RS00935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DK43_RS00940	COG0088	Forms part of the polypeptide exit tunnel
DK43_RS00945	COG0089	rRNA binding
DK43_RS00950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DK43_RS00960	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DK43_RS00965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DK43_RS00970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DK43_RS00975	COG0255	Belongs to the universal ribosomal protein uL29 family
DK43_RS00985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DK43_RS00990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DK43_RS00995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DK43_RS01000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DK43_RS01005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DK43_RS01010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DK43_RS01020	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DK43_RS01025	COG1841	ribosomal large subunit assembly
DK43_RS01030	COG0200	Binds to the 23S rRNA
DK43_RS01035	COG0201	protein transport
DK43_RS01040	COG0563	adenylate kinase activity
DK43_RS01045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DK43_RS01050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DK43_RS01055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DK43_RS01060	COG0202	RNA polymerase activity
DK43_RS01065	COG0203	ribosomal protein L17
DK43_RS01075	COG0052	Belongs to the universal ribosomal protein uS2 family
DK43_RS01080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DK43_RS01095	COG4463	regulation of RNA biosynthetic process
DK43_RS01110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DK43_RS01115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DK43_RS01145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DK43_RS01155	COG1396	sequence-specific DNA binding
DK43_RS01165	COG0166	Belongs to the GPI family
DK43_RS01170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DK43_RS01175	COG0594	ribonuclease P activity
DK43_RS01195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DK43_RS01200	COG0084	hydrolase, TatD family'
DK43_RS01220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DK43_RS01235	COG1162	GTPase activity
DK43_RS01245	COG1564	THIamine pyrophosphokinase
DK43_RS01255	COG3481	metal-dependent phosphohydrolase, HD sub domain
DK43_RS01260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DK43_RS01270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DK43_RS01275	COG0049	tRNA binding
DK43_RS01280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DK43_RS01300	COG1214	PFAM Peptidase M22, glycoprotease
DK43_RS01310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DK43_RS01325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DK43_RS01330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DK43_RS01335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DK43_RS01355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DK43_RS01365	COG0681	Belongs to the peptidase S26 family
DK43_RS01385	COG1193	negative regulation of DNA recombination
DK43_RS01395	COG3118	belongs to the thioredoxin family
DK43_RS01400	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DK43_RS01405	COG0668	transmembrane transport
DK43_RS01415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DK43_RS01420	COG0167	dihydroorotate dehydrogenase activity
DK43_RS01425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DK43_RS01425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DK43_RS01435	COG1940	carbohydrate kinase activity
DK43_RS01440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK43_RS01450	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK43_RS01455	COG1447	Phosphotransferase system cellobiose-specific component IIA
DK43_RS01465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK43_RS01465	COG2190	(PTS) system
DK43_RS01465	COG1263	PTS System
DK43_RS01495	COG0346	lactoylglutathione lyase activity
DK43_RS01505	COG0561	phosphatase activity
DK43_RS01525	COG1876	peptidase activity
DK43_RS01530	COG0028	Belongs to the TPP enzyme family
DK43_RS01535	COG1304	FMN binding
DK43_RS01540	COG2723	6-phospho-beta-galactosidase activity
DK43_RS01545	COG0745	RESPONSE REGULATOR receiver
DK43_RS01550	COG5002	protein histidine kinase activity
DK43_RS01575	COG1122	ATPase activity
DK43_RS01585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DK43_RS01605	COG0588	phosphoglycerate mutase activity
DK43_RS01610	COG0588	phosphoglycerate mutase activity
DK43_RS01635	COG0629	single-stranded DNA binding
DK43_RS01640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DK43_RS01655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DK43_RS01665	COG0006	proline dipeptidase activity
DK43_RS01670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DK43_RS01695	COG1609	Transcriptional regulator
DK43_RS01710	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DK43_RS01715	COG2176	DNA-directed DNA polymerase activity
DK43_RS01785	COG1187	pseudouridine synthase activity
DK43_RS01795	COG2801	Transposase and inactivated derivatives
DK43_RS01825	COG3344	reverse transcriptase
DK43_RS01855	COG1164	Oligoendopeptidase f
DK43_RS01860	COG1185	polyribonucleotide nucleotidyltransferase activity
DK43_RS01865	COG1045	serine acetyltransferase
DK43_RS01875	COG0215	cysteine-tRNA ligase activity
DK43_RS01880	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DK43_RS01890	COG3842	ATPase activity
DK43_RS01900	COG3688	RNA-binding protein containing a PIN domain
DK43_RS01910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DK43_RS01915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DK43_RS01920	COG4974	Belongs to the 'phage' integrase family
DK43_RS01940	COG3942	CHAP domain
DK43_RS01940	COG1705	Flagellar rod assembly protein muramidase FlgJ
DK43_RS01980	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DK43_RS02025	COG3830	Belongs to the UPF0237 family
DK43_RS02030	COG2848	UPF0210 protein
DK43_RS02035	COG0588	phosphoglycerate mutase activity
DK43_RS02040	COG0588	phosphoglycerate mutase activity
DK43_RS02045	COG1420	regulation of RNA biosynthetic process
DK43_RS02050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DK43_RS02060	COG0484	heat shock protein binding
DK43_RS02070	COG0101	tRNA pseudouridine synthase activity
DK43_RS02075	COG0351	phosphomethylpyrimidine kinase
DK43_RS02080	COG4720	Psort location CytoplasmicMembrane, score
DK43_RS02085	COG4475	Protein of unknown function (DUF436)
DK43_RS02090	COG0544	peptidyl-prolyl cis-trans isomerase activity
DK43_RS02100	COG0504	CTP synthase activity
DK43_RS02110	COG4166	transmembrane transport
DK43_RS02115	COG4166	transmembrane transport
DK43_RS02120	COG0601	transmembrane transport
DK43_RS02125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DK43_RS02130	COG0444	Belongs to the ABC transporter superfamily
DK43_RS02135	COG4608	Belongs to the ABC transporter superfamily
DK43_RS02145	COG1609	Transcriptional regulator
DK43_RS02150	COG1621	beta-fructofuranosidase activity
DK43_RS02155	COG1263	PTS System
DK43_RS02155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK43_RS02155	COG2190	(PTS) system
DK43_RS02160	COG1940	carbohydrate kinase activity
DK43_RS02165	COG0242	peptide deformylase activity
DK43_RS02180	COG1132	(ABC) transporter
DK43_RS02185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK43_RS02190	COG1447	Phosphotransferase system cellobiose-specific component IIA
DK43_RS02195	COG2723	6-phospho-beta-galactosidase activity
DK43_RS02200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK43_RS02205	COG2188	Transcriptional regulator
DK43_RS02210	COG1482	cell wall glycoprotein biosynthetic process
DK43_RS02215	COG0531	amino acid
DK43_RS02225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DK43_RS02230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DK43_RS02235	COG0736	holo-[acyl-carrier-protein] synthase activity
DK43_RS02240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DK43_RS02245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DK43_RS02250	COG0252	asparaginase activity
DK43_RS02255	COG0561	phosphatase activity
DK43_RS02260	COG2801	Transposase and inactivated derivatives
DK43_RS02270	COG0589	response to stress
DK43_RS02275	COG0436	Aminotransferase
DK43_RS02280	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DK43_RS02285	COG1335	isochorismatase
DK43_RS02290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DK43_RS02295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DK43_RS02300	COG0154	amidase activity
DK43_RS02305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DK43_RS02320	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DK43_RS02325	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DK43_RS02330	COG1534	Rna-binding protein
DK43_RS02335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DK43_RS02340	COG1713	HD superfamily hydrolase involved in NAD metabolism
DK43_RS02345	COG1335	isochorismatase
DK43_RS02350	COG0799	negative regulation of ribosome biogenesis
DK43_RS02355	COG2226	methyltransferase
DK43_RS02365	COG1323	Belongs to the UPF0348 family
DK43_RS02375	COG1396	sequence-specific DNA binding
DK43_RS02385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DK43_RS02390	COG1464	Belongs to the NlpA lipoprotein family
DK43_RS02395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DK43_RS02400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DK43_RS02485	COG2801	Transposase and inactivated derivatives
DK43_RS02505	COG4720	Psort location CytoplasmicMembrane, score
DK43_RS02535	COG1122	ATPase activity
DK43_RS02545	COG4221	oxidoreductase activity
DK43_RS02550	COG1442	glycosyl transferase family 8
DK43_RS02555	COG0357	Ribosomal RNA small subunit methyltransferase G
DK43_RS02560	COG1704	LemA family
DK43_RS02565	COG0501	Belongs to the peptidase M48B family
DK43_RS02595	COG1131	(ABC) transporter
DK43_RS02600	COG1309	transcriptional regulator
DK43_RS02605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DK43_RS02610	COG0745	RESPONSE REGULATOR receiver
DK43_RS02615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK43_RS02615	COG1263	PTS System
DK43_RS02615	COG2190	(PTS) system
DK43_RS02630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DK43_RS02640	COG1484	DNA-dependent DNA replication
DK43_RS02650	COG1160	GTP binding
DK43_RS02660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DK43_RS02670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DK43_RS02685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DK43_RS02710	COG1254	Belongs to the acylphosphatase family
DK43_RS02715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DK43_RS02740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DK43_RS02745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DK43_RS02760	COG4974	Belongs to the 'phage' integrase family
DK43_RS02765	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DK43_RS02770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DK43_RS02775	COG1187	pseudouridine synthase activity
DK43_RS02780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DK43_RS02795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DK43_RS02800	COG0569	domain protein
DK43_RS02810	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DK43_RS02815	COG0671	phosphoesterase, PA-phosphatase related
DK43_RS02825	COG1242	4 iron, 4 sulfur cluster binding
DK43_RS02830	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DK43_RS02840	COG0025	NhaP-type Na H and K H
DK43_RS02850	COG0494	nUDIX hydrolase
DK43_RS02865	COG0542	response to heat
DK43_RS02870	COG4703	Protein of unknown function (DUF1797)
DK43_RS02890	COG1136	(ABC) transporter
DK43_RS02895	COG0577	efflux transmembrane transporter activity
DK43_RS02900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DK43_RS02905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DK43_RS02920	COG1570	exodeoxyribonuclease VII activity
DK43_RS02925	COG1722	exodeoxyribonuclease VII activity
DK43_RS02935	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DK43_RS02940	COG1438	arginine binding
DK43_RS02945	COG0497	DNA recombination
DK43_RS02950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DK43_RS02955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DK43_RS02960	COG4604	ABC transporter, ATP-binding protein
DK43_RS02965	COG4605	iron ion homeostasis
DK43_RS02970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DK43_RS02975	COG1307	EDD domain protein, DegV family
DK43_RS02990	COG0588	phosphoglycerate mutase activity
DK43_RS02995	COG0768	penicillin binding
DK43_RS03000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DK43_RS03005	COG1181	Belongs to the D-alanine--D-alanine ligase family
DK43_RS03010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DK43_RS03055	COG3620	sequence-specific DNA binding
DK43_RS03080	COG0513	Belongs to the DEAD box helicase family
DK43_RS03090	COG1349	DNA-binding transcription factor activity
DK43_RS03095	COG0698	ribose 5-phosphate isomerase
DK43_RS03115	COG3775	system Galactitol-specific IIC component
DK43_RS03125	COG1755	Isoprenylcysteine carboxyl methyltransferase
DK43_RS03130	COG3711	transcriptional antiterminator
DK43_RS03140	COG1447	Phosphotransferase system cellobiose-specific component IIA
DK43_RS03145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK43_RS03145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK43_RS03150	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DK43_RS03160	COG2827	Endonuclease containing a URI domain
DK43_RS03165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DK43_RS03170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DK43_RS03175	COG0204	Acyl-transferase
DK43_RS03190	COG1476	TRANSCRIPTIONal
DK43_RS03205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DK43_RS03215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DK43_RS03225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DK43_RS03230	COG0322	excinuclease ABC activity
DK43_RS03240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DK43_RS03250	COG1573	uracil-dna glycosylase
DK43_RS03260	COG1732	Glycine betaine
DK43_RS03265	COG1125	glycine betaine transport
DK43_RS03285	COG0254	rRNA binding
DK43_RS03290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DK43_RS03295	COG0716	FMN binding
DK43_RS03305	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
DK43_RS03310	COG1518	maintenance of DNA repeat elements
DK43_RS03335	COG1309	transcriptional regulator
DK43_RS03340	COG1136	(ABC) transporter
DK43_RS03355	COG1959	2 iron, 2 sulfur cluster binding
DK43_RS03360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DK43_RS03365	COG1349	DNA-binding transcription factor activity
DK43_RS03375	COG1447	Phosphotransferase system cellobiose-specific component IIA
DK43_RS03385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK43_RS03390	COG1882	Formate acetyltransferase
DK43_RS03405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DK43_RS03405	COG0456	acetyltransferase
DK43_RS03420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DK43_RS03425	COG0406	alpha-ribazole phosphatase activity
DK43_RS03430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DK43_RS03445	COG0772	Belongs to the SEDS family
DK43_RS03450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DK43_RS03470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DK43_RS03485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DK43_RS03500	COG0813	purine-nucleoside phosphorylase activity
DK43_RS03510	COG1368	sulfuric ester hydrolase activity
DK43_RS03515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DK43_RS03520	COG0710	3-dehydroquinate dehydratase activity
DK43_RS03525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DK43_RS03530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DK43_RS03535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DK43_RS03540	COG0730	response to heat
DK43_RS03550	COG0287	Prephenate dehydrogenase
DK43_RS03555	COG3679	Belongs to the UPF0342 family
DK43_RS03565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DK43_RS03570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DK43_RS03575	COG0077	Prephenate dehydratase
DK43_RS03585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DK43_RS03595	COG1192	Involved in chromosome partitioning
DK43_RS03600	COG1475	DNA binding
DK43_RS03715	COG4509	Sortase family
DK43_RS03720	COG0791	NLP P60 protein
DK43_RS03720	COG0741	lytic transglycosylase activity
DK43_RS03745	COG1876	peptidase activity
DK43_RS03750	COG2720	vancomycin resistance protein
DK43_RS03755	COG1181	Belongs to the D-alanine--D-alanine ligase family
DK43_RS03780	COG2337	Toxic component of a toxin-antitoxin (TA) module
DK43_RS03785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DK43_RS03810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DK43_RS03850	COG3344	reverse transcriptase
DK43_RS03885	COG2226	methyltransferase
DK43_RS03890	COG1191	sigma factor activity
DK43_RS03920	COG1484	DNA-dependent DNA replication
DK43_RS03970	COG0551	DNA topoisomerase type I activity
DK43_RS03970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DK43_RS03990	COG0464	growth
DK43_RS04010	COG4977	sequence-specific DNA binding
DK43_RS04010	COG1917	Cupin 2, conserved barrel domain protein
DK43_RS04015	COG1132	(ABC) transporter
DK43_RS04020	COG1132	(ABC) transporter
DK43_RS04065	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DK43_RS04070	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DK43_RS04085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DK43_RS04115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DK43_RS04120	COG0492	ferredoxin-NADP+ reductase activity
DK43_RS04130	COG1349	DNA-binding transcription factor activity
DK43_RS04135	COG1105	Belongs to the carbohydrate kinase PfkB family
DK43_RS04140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DK43_RS04140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DK43_RS04140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DK43_RS04150	COG1307	EDD domain protein, DegV family
DK43_RS04155	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DK43_RS04160	COG0617	tRNA 3'-terminal CCA addition
DK43_RS04165	COG0488	(ABC) transporter
DK43_RS04180	COG0072	phenylalanine-tRNA ligase activity
DK43_RS04180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DK43_RS04195	COG1268	BioY protein
DK43_RS04200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DK43_RS04210	COG1136	(ABC) transporter
DK43_RS04215	COG0577	efflux transmembrane transporter activity
DK43_RS04220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DK43_RS04225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DK43_RS04245	COG0300	oxidoreductase activity
DK43_RS04260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DK43_RS04260	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DK43_RS04270	COG1131	(ABC) transporter
DK43_RS04275	COG1725	Transcriptional regulator
DK43_RS04285	COG0205	6-phosphofructokinase activity
DK43_RS04290	COG0469	pyruvate kinase activity
DK43_RS04300	COG0765	amino acid transport
DK43_RS04305	COG1126	abc transporter atp-binding protein
DK43_RS04315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DK43_RS04320	COG0210	DNA helicase
DK43_RS04325	COG1051	belongs to the nudix hydrolase family
DK43_RS04330	COG2378	regulation of single-species biofilm formation
DK43_RS04335	COG1132	(ABC) transporter
DK43_RS04335	COG2375	cellular response to nickel ion
DK43_RS04340	COG1132	(ABC) transporter
DK43_RS04350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DK43_RS04355	COG0196	riboflavin kinase activity
DK43_RS04360	COG1393	Belongs to the ArsC family
DK43_RS04365	COG4476	Belongs to the UPF0223 family
DK43_RS04370	COG0483	inositol monophosphate 1-phosphatase activity
DK43_RS04375	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DK43_RS04375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DK43_RS04385	COG0573	inorganic phosphate transmembrane transporter activity
DK43_RS04390	COG0581	inorganic phosphate transmembrane transporter activity
DK43_RS04395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DK43_RS04400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DK43_RS04405	COG0704	Plays a role in the regulation of phosphate uptake
DK43_RS04410	COG2003	Belongs to the UPF0758 family
DK43_RS04415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DK43_RS04430	COG1104	cysteine desulfurase activity
DK43_RS04435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DK43_RS04445	COG2357	RelA SpoT domain protein
DK43_RS04455	COG0564	pseudouridine synthase activity
DK43_RS04460	COG0280	phosphate acetyltransferase
DK43_RS04475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DK43_RS04480	COG4684	Psort location CytoplasmicMembrane, score
DK43_RS04485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DK43_RS04495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DK43_RS04515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DK43_RS04520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DK43_RS04535	COG2207	Transcriptional regulator
DK43_RS04535	COG3708	Transcriptional regulator
DK43_RS04540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DK43_RS04545	COG0222	ribosome binding
DK43_RS04555	COG0270	DNA (cytosine-5-)-methyltransferase activity
DK43_RS04675	COG1396	sequence-specific DNA binding
DK43_RS04680	COG0542	response to heat
DK43_RS04685	COG0613	PHP domain protein
DK43_RS04690	COG1196	nuclear chromosome segregation
DK43_RS04705	COG3843	relaxase mobilization nuclease domain protein
DK43_RS04720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DK43_RS04755	COG4221	oxidoreductase activity
DK43_RS04755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DK43_RS04755	COG1028	Short-chain dehydrogenase reductase Sdr
DK43_RS04755	COG3321	synthase
DK43_RS04770	COG1396	sequence-specific DNA binding
DK43_RS04780	COG4974	Belongs to the 'phage' integrase family
DK43_RS04790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DK43_RS04795	COG0336	Belongs to the RNA methyltransferase TrmD family
DK43_RS04800	COG3443	Belongs to the bacterial solute-binding protein 9 family
DK43_RS04800	COG0803	Belongs to the bacterial solute-binding protein 9 family
DK43_RS04810	COG1956	GAF domain-containing protein
DK43_RS04815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DK43_RS04825	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DK43_RS04825	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DK43_RS04830	COG1609	Transcriptional regulator
DK43_RS04835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DK43_RS04845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DK43_RS04845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DK43_RS04850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DK43_RS04860	COG0726	polysaccharide deacetylase
DK43_RS04870	COG0083	homoserine kinase activity
DK43_RS04905	COG1940	carbohydrate kinase activity
DK43_RS04940	COG1674	ftsk spoiiie
DK43_RS04990	COG0745	RESPONSE REGULATOR receiver
DK43_RS04995	COG5002	protein histidine kinase activity
DK43_RS05005	COG4187	Peptidase family M20/M25/M40
DK43_RS05015	COG0268	Binds directly to 16S ribosomal RNA
DK43_RS05020	COG1072	(Pantothenic acid kinase))
DK43_RS05025	COG2813	Specifically methylates the guanine in position
DK43_RS05035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DK43_RS05040	COG0295	cytidine deaminase activity
DK43_RS05045	COG1744	ABC transporter substrate-binding protein PnrA-like
DK43_RS05050	COG3845	ABC transporter
DK43_RS05055	COG4603	Belongs to the binding-protein-dependent transport system permease family
DK43_RS05060	COG1079	Belongs to the binding-protein-dependent transport system permease family
DK43_RS05065	COG1272	protein, Hemolysin III
DK43_RS05075	COG3022	response to hydroperoxide
DK43_RS05085	COG1846	Transcriptional regulator
DK43_RS05095	COG0436	Aminotransferase
DK43_RS05105	COG0017	Asparaginyl-tRNA synthetase
DK43_RS05110	COG2814	Major facilitator Superfamily
DK43_RS05155	COG1309	transcriptional regulator
DK43_RS05160	COG2131	deaminase
DK43_RS05170	COG0737	Belongs to the 5'-nucleotidase family
DK43_RS05175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DK43_RS05180	COG0187	DNA topoisomerase II activity
DK43_RS05200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DK43_RS05205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DK43_RS05225	COG0539	negative regulation of cytoplasmic translation
DK43_RS05240	COG0039	L-malate dehydrogenase activity
DK43_RS05245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DK43_RS05250	COG3764	Sortase (surface protein transpeptidase)
DK43_RS05255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DK43_RS05260	COG1960	acyl-CoA dehydrogenase activity
DK43_RS05265	COG1250	3-hydroxyacyl-CoA dehydrogenase
DK43_RS05270	COG0183	Belongs to the thiolase family
DK43_RS05275	COG1024	Enoyl-CoA hydratase
DK43_RS05285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DK43_RS05290	COG0583	DNA-binding transcription factor activity
DK43_RS05295	COG1960	acyl-CoA dehydrogenase activity
DK43_RS05300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DK43_RS05305	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DK43_RS05310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DK43_RS05315	COG3711	transcriptional antiterminator
DK43_RS05320	COG0110	maltose O-acetyltransferase activity
DK43_RS05325	COG0758	DNA mediated transformation
DK43_RS05330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DK43_RS05335	COG0135	phosphoribosylanthranilate isomerase activity
DK43_RS05340	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DK43_RS05360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DK43_RS05365	COG0022	dehydrogenase e1 component
DK43_RS05370	COG0508	dehydrogenase complex catalyzes the overall conversion of
DK43_RS05375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DK43_RS05380	COG0095	Lipoate-protein ligase
DK43_RS05385	COG4974	Belongs to the 'phage' integrase family
DK43_RS05390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DK43_RS05400	COG2188	Transcriptional regulator
DK43_RS05425	COG0741	lytic transglycosylase activity
DK43_RS05435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DK43_RS05445	COG2890	protein-(glutamine-N5) methyltransferase activity
DK43_RS05455	COG1435	thymidine kinase activity
DK43_RS05460	COG1942	4-Oxalocrotonate Tautomerase
DK43_RS05465	COG0534	Mate efflux family protein
DK43_RS05470	COG2233	PERMEase
DK43_RS05475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DK43_RS05485	COG0038	chloride channel
DK43_RS05505	COG0431	NADPH-dependent FMN reductase
DK43_RS05505	COG1053	succinate dehydrogenase
DK43_RS05505	COG3976	FMN-binding domain protein
DK43_RS05510	COG4555	ABC transporter
DK43_RS05525	COG2972	Histidine kinase
DK43_RS05530	COG2197	response regulator
DK43_RS05535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DK43_RS05535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DK43_RS05540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DK43_RS05545	COG0785	Cytochrome C biogenesis protein
DK43_RS05550	COG1114	Component of the transport system for branched-chain amino acids
DK43_RS05555	COG2151	metal-sulfur cluster biosynthetic enzyme
DK43_RS05560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DK43_RS05565	COG0358	DNA primase activity
DK43_RS05570	COG1970	mechanosensitive ion channel activity
DK43_RS05575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DK43_RS05590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DK43_RS05595	COG1132	(ABC) transporter
DK43_RS05600	COG1132	(ABC) transporter
DK43_RS05605	COG2315	Protein conserved in bacteria
DK43_RS05610	COG3142	Participates in the control of copper homeostasis
DK43_RS05625	COG1827	regulation of RNA biosynthetic process
DK43_RS05630	COG1837	Belongs to the UPF0109 family
DK43_RS05635	COG0228	four-way junction DNA binding
DK43_RS05640	COG1523	belongs to the glycosyl hydrolase 13 family
DK43_RS05645	COG1597	lipid kinase activity
DK43_RS05650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DK43_RS05655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DK43_RS05665	COG4708	membrane
DK43_RS05670	COG2246	polysaccharide biosynthetic process
DK43_RS05680	COG1846	Transcriptional regulator
DK43_RS05690	COG0024	Methionine aminopeptidase
DK43_RS05695	COG4109	DRTGG domain
DK43_RS05705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DK43_RS05710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DK43_RS05715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DK43_RS05720	COG1051	belongs to the nudix hydrolase family
DK43_RS05725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DK43_RS05740	COG0658	competence protein
DK43_RS05740	COG2333	competence protein COMEC
DK43_RS05755	COG0557	exoribonuclease II activity
DK43_RS05765	COG2814	Major facilitator Superfamily
DK43_RS05770	COG0237	dephospho-CoA kinase activity
DK43_RS05775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DK43_RS05805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DK43_RS05810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DK43_RS05815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DK43_RS05820	COG1132	(ABC) transporter
DK43_RS05825	COG1132	(ABC) transporter
DK43_RS05845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DK43_RS05850	COG0686	Belongs to the AlaDH PNT family
DK43_RS05875	COG1702	phosphate starvation-inducible protein PhoH
DK43_RS05880	COG4479	Belongs to the UPF0346 family
DK43_RS05890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DK43_RS05900	COG0284	orotidine-5'-phosphate decarboxylase activity
DK43_RS05905	COG0167	dihydroorotate dehydrogenase activity
DK43_RS05910	COG0543	2 iron, 2 sulfur cluster binding
DK43_RS05930	COG0583	DNA-binding transcription factor activity
DK43_RS05935	COG2814	Major facilitator Superfamily
DK43_RS05940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DK43_RS05945	COG0505	Belongs to the CarA family
DK43_RS05950	COG0540	Belongs to the ATCase OTCase family
DK43_RS05960	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DK43_RS05965	COG1481	regulation of sporulation
DK43_RS05970	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DK43_RS05975	COG1660	Displays ATPase and GTPase activities
DK43_RS05995	COG0647	UMP catabolic process
DK43_RS06005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DK43_RS06015	COG1131	(ABC) transporter
DK43_RS06030	COG0556	nucleotide-excision repair
DK43_RS06050	COG0488	(ABC) transporter
DK43_RS06055	COG1132	(ABC) transporter
DK43_RS06065	COG1388	LysM domain
DK43_RS06065	COG1705	Flagellar rod assembly protein muramidase FlgJ
DK43_RS06070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DK43_RS06085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DK43_RS06090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DK43_RS06095	COG0038	chloride channel
DK43_RS06125	COG2824	Alkylphosphonate utilization operon protein PhnA
DK43_RS06130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DK43_RS06135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DK43_RS06140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DK43_RS06145	COG0564	pseudouridine synthase activity
DK43_RS06155	COG0583	DNA-binding transcription factor activity
DK43_RS06160	COG1937	Protein conserved in bacteria
DK43_RS06170	COG1054	Belongs to the UPF0176 family
DK43_RS06175	COG0446	pyridine nucleotide-disulphide oxidoreductase
DK43_RS06180	COG0425	Belongs to the sulfur carrier protein TusA family
DK43_RS06180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DK43_RS06195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DK43_RS06205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DK43_RS06210	COG0301	tRNA thio-modification
DK43_RS06215	COG1104	cysteine desulfurase activity
DK43_RS06220	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DK43_RS06225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DK43_RS06230	COG0517	IMP dehydrogenase activity
DK43_RS06235	COG0574	Belongs to the PEP-utilizing enzyme family
DK43_RS06235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DK43_RS06250	COG1177	transmembrane transport
DK43_RS06255	COG1176	ABC-type spermidine putrescine transport system, permease component I
DK43_RS06260	COG3842	ATPase activity
DK43_RS06265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DK43_RS06275	COG0481	GTPase activity
DK43_RS06280	COG0561	phosphatase activity
DK43_RS06285	COG2195	Cleaves the N-terminal amino acid of tripeptides
DK43_RS06295	COG0572	uridine kinase
DK43_RS06300	COG0673	inositol 2-dehydrogenase activity
DK43_RS06310	COG0726	polysaccharide deacetylase
DK43_RS06315	COG0346	lactoylglutathione lyase activity
DK43_RS06325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DK43_RS06335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DK43_RS06360	COG0560	Phosphoserine phosphatase
DK43_RS06365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DK43_RS06375	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DK43_RS06380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DK43_RS06385	COG3442	glutamine amidotransferase
DK43_RS06395	COG0488	(ABC) transporter
DK43_RS06420	COG0826	peptidase U32
DK43_RS06445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DK43_RS06450	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DK43_RS06465	COG3091	SprT-like family
DK43_RS06470	COG2183	response to ionizing radiation
DK43_RS06490	COG0701	Predicted permease
DK43_RS06495	COG3689	TIGRFAM TIGR03943 family protein
DK43_RS06500	COG0477	Major facilitator Superfamily
DK43_RS06505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DK43_RS06510	COG0552	protein localization to endoplasmic reticulum
DK43_RS06515	COG0561	phosphatase activity
DK43_RS06520	COG0561	phosphatase activity
DK43_RS06525	COG1196	nuclear chromosome segregation
DK43_RS06530	COG0571	ribonuclease III activity
DK43_RS06540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DK43_RS06545	COG5002	protein histidine kinase activity
DK43_RS06550	COG0745	RESPONSE REGULATOR receiver
DK43_RS06560	COG0438	transferase activity, transferring glycosyl groups
DK43_RS06570	COG1609	Transcriptional regulator
DK43_RS06575	COG0006	proline dipeptidase activity
DK43_RS06580	COG1368	sulfuric ester hydrolase activity
DK43_RS06620	COG1442	glycosyl transferase family 8
DK43_RS06620	COG1216	Glycosyl transferase, family 2
DK43_RS06635	COG0463	Glycosyl transferase, family 2
DK43_RS06640	COG1442	glycosyl transferase family 8
DK43_RS06640	COG1216	Glycosyl transferase, family 2
DK43_RS06645	COG1215	transferase activity, transferring glycosyl groups
DK43_RS06655	COG1091	dTDP-4-dehydrorhamnose reductase activity
DK43_RS06670	COG0463	Glycosyl transferase, family 2
DK43_RS06675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DK43_RS06680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DK43_RS06685	COG1088	dTDP-glucose 4,6-dehydratase activity
DK43_RS06695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DK43_RS06710	COG0494	nUDIX hydrolase
DK43_RS06715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DK43_RS06720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DK43_RS06725	COG2384	SAM-dependent methyltransferase
DK43_RS06735	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DK43_RS06740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DK43_RS06745	COG1346	cytolysis
DK43_RS06760	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DK43_RS06765	COG1132	(ABC) transporter
DK43_RS06785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DK43_RS06805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DK43_RS06810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DK43_RS06815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DK43_RS06820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DK43_RS06825	COG0356	it plays a direct role in the translocation of protons across the membrane
DK43_RS06835	COG0058	SHG alpha-glucan phosphorylase activity
DK43_RS06840	COG0297	glycogen (starch) synthase activity
DK43_RS06845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DK43_RS06850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DK43_RS06855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DK43_RS06860	COG1074	ATP-dependent DNA helicase activity
DK43_RS06865	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DK43_RS06870	COG1668	transmembrane transport
DK43_RS06875	COG4152	abc transporter atp-binding protein
DK43_RS06880	COG4443	Transcriptional Coactivator p15 (PC4)
DK43_RS06890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DK43_RS06905	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DK43_RS06910	COG3527	Alpha-acetolactate decarboxylase
DK43_RS06915	COG0028	Belongs to the TPP enzyme family
DK43_RS06925	COG0628	permease
DK43_RS06930	COG5002	protein histidine kinase activity
DK43_RS06930	COG3850	Histidine kinase
DK43_RS06935	COG0745	RESPONSE REGULATOR receiver
DK43_RS06945	COG2706	6-phosphogluconolactonase activity
DK43_RS06950	COG2801	Transposase and inactivated derivatives
DK43_RS06960	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DK43_RS06965	COG0187	DNA topoisomerase II activity
DK43_RS06980	COG0772	Belongs to the SEDS family
DK43_RS06990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DK43_RS06990	COG1199	ATP-dependent helicase activity
DK43_RS07000	COG2177	Part of the ABC transporter FtsEX involved in
DK43_RS07005	COG2884	Cell division ATP-binding protein ftsE
DK43_RS07010	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DK43_RS07015	COG0561	phosphatase activity
DK43_RS07045	COG1078	dGTPase activity
DK43_RS07055	COG2348	transferase activity, transferring amino-acyl groups
DK43_RS07060	COG2348	transferase activity, transferring amino-acyl groups
DK43_RS07075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DK43_RS07085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DK43_RS07095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DK43_RS07100	COG4122	O-methyltransferase activity
DK43_RS07115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DK43_RS07125	COG1447	Phosphotransferase system cellobiose-specific component IIA
DK43_RS07130	COG3711	transcriptional antiterminator
DK43_RS07130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DK43_RS07140	COG4095	Psort location CytoplasmicMembrane, score
DK43_RS07150	COG2723	6-phospho-beta-galactosidase activity
DK43_RS07170	COG0363	glucosamine-6-phosphate deaminase activity
DK43_RS07175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DK43_RS07180	COG1438	arginine binding
DK43_RS07190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DK43_RS07195	COG1288	antiporter activity
DK43_RS07200	COG0549	Belongs to the carbamate kinase family
DK43_RS07205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DK43_RS07235	COG2274	protein secretion by the type I secretion system
DK43_RS07240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DK43_RS07245	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DK43_RS07250	COG1466	dna polymerase III delta subunit
DK43_RS07255	COG2996	Protein conserved in bacteria
DK43_RS07260	COG0233	cytoplasmic translational termination
DK43_RS07265	COG0528	UMP kinase activity
DK43_RS07270	COG0538	isocitrate dehydrogenase activity
DK43_RS07275	COG0372	Belongs to the citrate synthase family
DK43_RS07280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DK43_RS07285	COG0081	regulation of translation
DK43_RS07300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DK43_RS07305	COG0697	spore germination
DK43_RS07305	COG1674	ftsk spoiiie
DK43_RS07310	COG1983	PspC domain protein
DK43_RS07320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DK43_RS07325	COG0488	(ABC) transporter
DK43_RS07330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DK43_RS07345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DK43_RS07370	COG1028	Short-chain dehydrogenase reductase Sdr
DK43_RS07380	COG0582	viral genome integration into host DNA
DK43_RS07430	COG0740	serine-type endopeptidase activity
DK43_RS07465	COG0531	amino acid
DK43_RS07470	COG0577	efflux transmembrane transporter activity
DK43_RS07475	COG1136	(ABC) transporter
DK43_RS07500	COG0577	efflux transmembrane transporter activity
DK43_RS07505	COG1136	(ABC) transporter
DK43_RS07515	COG0642	Histidine kinase
DK43_RS07520	COG0745	RESPONSE REGULATOR receiver
DK43_RS07530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DK43_RS07530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DK43_RS07555	COG0640	Transcriptional regulator
DK43_RS07565	COG0708	Exodeoxyribonuclease III
DK43_RS07570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DK43_RS07575	COG1393	Belongs to the ArsC family
DK43_RS07580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DK43_RS07590	COG4467	Involved in initiation control of chromosome replication
DK43_RS07595	COG0470	DNA polymerase III
DK43_RS07600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DK43_RS07605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DK43_RS07610	COG0517	IMP dehydrogenase activity
DK43_RS07625	COG4177	L-phenylalanine transmembrane transporter activity
DK43_RS07645	COG0740	serine-type endopeptidase activity
DK43_RS07650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DK43_RS07655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DK43_RS07660	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DK43_RS07665	COG0626	cystathionine gamma-synthase activity
DK43_RS07670	COG2244	polysaccharide biosynthetic process
DK43_RS07675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DK43_RS07700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DK43_RS07710	COG0366	Alpha amylase catalytic
DK43_RS07715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK43_RS07715	COG1263	PTS System
DK43_RS07720	COG2188	Transcriptional regulator
DK43_RS07725	COG1253	flavin adenine dinucleotide binding
DK43_RS07735	COG0628	permease
DK43_RS07745	COG1846	Transcriptional regulator
DK43_RS07750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DK43_RS07755	COG3599	regulation of cell shape
DK43_RS07770	COG1799	cell septum assembly
DK43_RS07775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DK43_RS07780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DK43_RS07790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DK43_RS07795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DK43_RS07800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DK43_RS07810	COG1217	gtp-binding protein TYPA
DK43_RS07815	COG1187	pseudouridine synthase activity
DK43_RS07850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DK43_RS07855	COG4470	Protein conserved in bacteria
DK43_RS07860	COG3480	Lon protease (S16) C-terminal proteolytic domain
DK43_RS07865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DK43_RS07870	COG0742	ribosomal rna small subunit methyltransferase
DK43_RS07880	COG1040	competence protein
DK43_RS07885	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DK43_RS07890	COG1739	Uncharacterized protein family UPF0029
DK43_RS07925	COG0519	Catalyzes the synthesis of GMP from XMP
DK43_RS07945	COG2070	2-Nitropropane dioxygenase
DK43_RS07955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DK43_RS07960	COG2137	regulation of response to DNA damage stimulus
DK43_RS07965	COG3557	Belongs to the UPF0374 family
DK43_RS07975	COG1185	polyribonucleotide nucleotidyltransferase activity
DK43_RS07990	COG4585	Histidine kinase
DK43_RS08000	COG2815	serine threonine protein kinase
DK43_RS08000	COG0515	serine threonine protein kinase
DK43_RS08005	COG0631	protein serine/threonine phosphatase activity
DK43_RS08010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DK43_RS08010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DK43_RS08015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DK43_RS08020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DK43_RS08025	COG1758	RNA polymerase activity
DK43_RS08030	COG0194	GDP metabolic process
DK43_RS08035	COG1418	mRNA catabolic process
DK43_RS08045	COG3634	alkyl hydroperoxide reductase activity
DK43_RS08050	COG0450	alkyl hydroperoxide reductase
DK43_RS08060	COG0116	Belongs to the methyltransferase superfamily
DK43_RS08065	COG3599	regulation of cell shape
DK43_RS08070	COG4474	Belongs to the UPF0398 family
DK43_RS08075	COG3331	DNA recombination
DK43_RS08080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DK43_RS08085	COG3579	cysteine-type endopeptidase activity
DK43_RS08090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DK43_RS08095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DK43_RS08100	COG1113	amino acid transport
DK43_RS08105	COG0492	ferredoxin-NADP+ reductase activity
DK43_RS08115	COG1126	abc transporter atp-binding protein
DK43_RS08125	COG0513	Belongs to the DEAD box helicase family
DK43_RS08130	COG1686	Belongs to the peptidase S11 family
DK43_RS08140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DK43_RS08145	COG0719	Fe-S assembly protein
DK43_RS08155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DK43_RS08160	COG4862	establishment of competence for transformation
DK43_RS08165	COG1968	undecaprenyl-diphosphatase activity
DK43_RS08175	COG0765	amino acid transport
DK43_RS08180	COG1126	abc transporter atp-binding protein
DK43_RS08195	COG2197	response regulator
DK43_RS08200	COG4585	Histidine kinase
DK43_RS08210	COG1131	(ABC) transporter
DK43_RS08215	COG1461	Dihydroxyacetone kinase
DK43_RS08225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DK43_RS08250	COG0191	fructose-bisphosphate aldolase activity
DK43_RS08265	COG2801	Transposase and inactivated derivatives
DK43_RS08275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DK43_RS08280	COG0768	penicillin binding
DK43_RS08290	COG0275	rRNA processing
DK43_RS08305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DK43_RS08320	COG0751	glycine-tRNA ligase activity
DK43_RS08325	COG0752	glycyl-tRNA synthetase alpha subunit
DK43_RS08345	COG0656	L-ascorbic acid biosynthetic process
DK43_RS08360	COG1283	sodium-dependent phosphate transmembrane transporter activity
DK43_RS08365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DK43_RS08380	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DK43_RS08385	COG0195	Participates in both transcription termination and antitermination
DK43_RS08390	COG0779	Required for maturation of 30S ribosomal subunits
DK43_RS08400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DK43_RS08405	COG0510	thiamine kinase activity
DK43_RS08415	COG1131	(ABC) transporter
DK43_RS08420	COG0537	adenosine 5'-monophosphoramidase activity
DK43_RS08430	COG1316	TRANSCRIPTIONal
DK43_RS08440	COG0802	atpase or kinase
DK43_RS08445	COG2252	PERMEase
DK43_RS08455	COG0561	phosphatase activity
DK43_RS08465	COG3715	PTS system
DK43_RS08470	COG3716	PTS system mannose fructose sorbose family IID component
DK43_RS08485	COG0586	Pfam SNARE associated Golgi protein
DK43_RS08490	COG0825	malonyl-CoA metabolic process
DK43_RS08495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DK43_RS08500	COG0439	Biotin carboxylase
DK43_RS08505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DK43_RS08515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DK43_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
DK43_RS08525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DK43_RS08530	COG2070	2-Nitropropane dioxygenase
DK43_RS08540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DK43_RS08550	COG1024	Enoyl-CoA hydratase
DK43_RS08555	COG0527	aspartate kinase activity
DK43_RS08585	COG0495	leucyl-tRNA aminoacylation
DK43_RS08590	COG1132	(ABC) transporter
DK43_RS08595	COG4988	ABC transporter
DK43_RS08600	COG3590	peptidase
DK43_RS08625	COG1490	D-aminoacyl-tRNA deacylase activity
DK43_RS08635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DK43_RS08640	COG2264	protein methyltransferase activity
DK43_RS08650	COG1051	belongs to the nudix hydrolase family
DK43_RS08660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DK43_RS08680	COG1418	mRNA catabolic process
DK43_RS08685	COG1428	Deoxynucleoside kinase
DK43_RS08695	COG0459	protein refolding
DK43_RS08700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DK43_RS08710	COG3716	PTS system mannose fructose sorbose family IID component
DK43_RS08715	COG3715	PTS system
DK43_RS08735	COG2197	response regulator
DK43_RS08740	COG4585	Histidine kinase
DK43_RS08755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DK43_RS08760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DK43_RS08770	COG1363	Peptidase, m42
DK43_RS08780	COG0285	dihydrofolate synthase activity
DK43_RS08790	COG0442	prolyl-tRNA aminoacylation
DK43_RS08795	COG0750	zinc metalloprotease
DK43_RS08800	COG4589	Belongs to the CDS family
DK43_RS08805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DK43_RS08815	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
DK43_RS08820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DK43_RS08840	COG3623	hexulose-6-phosphate isomerase
DK43_RS08850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DK43_RS08860	COG3037	sugar-specific permease SgaT UlaA
DK43_RS08875	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DK43_RS08905	COG4537	Required for transformation and DNA binding
DK43_RS08910	COG1459	type II secretion system
DK43_RS08915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DK43_RS08925	COG0174	glutamine synthetase
DK43_RS08930	COG0789	Transcriptional regulator
DK43_RS08940	COG3942	CHAP domain
DK43_RS08945	COG3064	Membrane
DK43_RS08945	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DK43_RS08950	COG0126	phosphoglycerate kinase activity
DK43_RS08955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DK43_RS08960	COG0085	RNA polymerase activity
DK43_RS08970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DK43_RS08980	COG2226	methyltransferase
DK43_RS08990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DK43_RS08995	COG1473	amidohydrolase
DK43_RS09000	COG2171	N-acyltransferase activity
DK43_RS09005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DK43_RS09015	COG0756	dUTP diphosphatase activity
DK43_RS09035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DK43_RS09040	COG1882	Formate acetyltransferase
DK43_RS09055	COG3425	synthase
DK43_RS09065	COG1304	FMN binding
DK43_RS09085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DK43_RS09100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DK43_RS09110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DK43_RS09115	COG0584	glycerophosphoryl diester phosphodiesterase
DK43_RS09130	COG2081	HI0933 family
DK43_RS09135	COG0789	Transcriptional regulator
DK43_RS09280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DK43_RS09285	COG0564	pseudouridine synthase activity
DK43_RS09305	COG3443	Belongs to the bacterial solute-binding protein 9 family
DK43_RS09305	COG0803	Belongs to the bacterial solute-binding protein 9 family
DK43_RS09310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DK43_RS09315	COG1121	(ABC) transporter
DK43_RS09320	COG1846	Transcriptional regulator
DK43_RS09345	COG1914	H( )-stimulated, divalent metal cation uptake system
DK43_RS09350	COG3759	membrane
DK43_RS09360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DK43_RS09360	COG0131	Imidazoleglycerol-phosphate dehydratase
DK43_RS09375	COG1394	ATPase activity, coupled to movement of substances
DK43_RS09380	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
DK43_RS09385	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DK43_RS09395	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
DK43_RS09400	COG1527	subunit (C
DK43_RS09410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DK43_RS09415	COG1269	ATP hydrolysis coupled proton transport
DK43_RS09435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DK43_RS09445	COG2731	YhcH YjgK YiaL family protein
DK43_RS09450	COG0395	ABC-type sugar transport system, permease component
DK43_RS09455	COG1175	transmembrane transport
DK43_RS09465	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DK43_RS09470	COG1454	alcohol dehydrogenase
DK43_RS09475	COG1454	alcohol dehydrogenase
DK43_RS09475	COG1012	belongs to the aldehyde dehydrogenase family
DK43_RS09490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DK43_RS09515	COG2255	four-way junction helicase activity
DK43_RS09525	COG3684	Belongs to the aldolase LacD family
DK43_RS09530	COG2222	sugar isomerase
DK43_RS09540	COG3716	PTS system mannose fructose sorbose family IID component
DK43_RS09550	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DK43_RS09570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DK43_RS09575	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DK43_RS09580	COG1461	Dihydroxyacetone kinase
DK43_RS09585	COG2376	Dihydroxyacetone kinase
DK43_RS09595	COG2376	Dihydroxyacetone kinase
DK43_RS09600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DK43_RS09620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DK43_RS09625	COG1683	Conserved Protein
DK43_RS09630	COG0151	Belongs to the GarS family
DK43_RS09640	COG2801	Transposase and inactivated derivatives
DK43_RS09670	COG3942	CHAP domain
DK43_RS09685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DK43_RS09690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DK43_RS09700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DK43_RS09705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DK43_RS09710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DK43_RS09720	COG1381	Involved in DNA repair and RecF pathway recombination
DK43_RS09725	COG0436	Aminotransferase
DK43_RS09730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DK43_RS09735	COG3942	CHAP domain
DK43_RS09745	COG1792	Involved in formation and maintenance of cell shape
DK43_RS09875	COG3620	sequence-specific DNA binding